Search

High-resolution spectroscopy has proven to be a powerful avenue for atmospheric remote sensing of exoplanets. Recently, ESO commissioned the CRIRES+ high-resolution infrared spectrograph at VLT. CRIRES+ is a cross-dispersed spectrograph with high throughput and wide wavelength coverage across the near-infrared (0.95-5.3 $\mu$m), designed to be particularly suited for atmospheric characterisation of exoplanets. In this work, we report early insights into the performance of CRIRES+ for exoplanet spectroscopy and conduct a detailed assessment of the data reduction procedure. Because of the novelty of the instrument, we perform two independent data reduction strategies, using the official CR2RES pipeline and our new custom-built ExoRES pipeline. Using science verification observations we find that the spectral resolving power of CRIRES+ can reach $R \gtrsim 100,000$ for optimal observing conditions. Similarly, we find the signal-to-noise ratio (S/N) to be consistent with expected and empirical estimates for the observations considered. As a case study, we perform the first application of CRIRES+ to the atmospheric characterisation of an exoplanet - the ultra-hot Jupiter MASCARA-1 b. We detect CO and H$_2$O in the atmosphere of MASCARA-1 b at a S/N of 12.9 and 5.3, respectively, and a temperature inversion revealed through the CO and H$_2$O emission lines, the first for an exoplanet. We find a combined S/N of 13.8 for CO and H$_2$O together, with a preference for lower H$_2$O abundance compared to CO. Our findings demonstrate the scientific potential of CRIRES+ and highlight the excellent opportunity for high-resolution atmospheric spectroscopy of diverse exoplanets., Comment: Accepted version updated with proof edits

Atmospheric retrievals of exoplanet transmission spectra allow constraints on the composition and structure of the day-night terminator region. Such retrievals in the past have typically assumed one-dimensional temperature structures which were adequate to explain extant observations. However, the increasing data quality expected from exoplanet spectroscopy with JWST motivates considerations of multidimensional atmospheric retrievals. We present AURA-3D, a three-dimensional atmospheric retrieval framework for exoplanet transmission spectra. AURA-3D includes a forward model that enables rapid computation of transmission spectra in 3D geometry for a given atmospheric structure and can, therefore, be used for atmospheric retrievals as well as for computing spectra from General Circulation Models (GCMs). In order to efficiently explore the space of possible 3D temperature structures in retrievals, we develop a parametric 3D pressure-temperature profile which can accurately represent azimuthally-averaged temperature structures of a range of hot Jupiter GCMs. We apply our retrieval framework to simulated JWST observations of hot Jupiter transmission spectra, obtaining accurate estimates of the day-night temperature variation across the terminator as well as the abundances of chemical species. We demonstrate an example of a model hot Jupiter transmission spectrum for which a traditional 1D retrieval of JWST-quality data returns biased abundance estimates, whereas a retrieval including a day-night temperature gradient can accurately retrieve the true abundances. Our forward model also has the capability to include inhomogeneous chemistry as well as variable clouds/hazes. This new retrieval framework opens the field to detailed multidimensional atmospheric characterisation using transmission spectra of exoplanets in the JWST era., 27 pages, 16 figures. Accepted for publication in ApJ

Plasma technology is actively used for nanoparticle synthesis and modification. All plasma techniques share the ambition of providing high quality, nanostructured materials with full control over their crystalline state and functional properties. Pulsed-DC physical/chemical vapour deposition, high power impulse magnetron sputtering, and pulsed cathodic arc are consolidated low-temperature plasma processes for the synthesis of high-quality nanocomposite films in vacuum environment. However, atmospheric arc discharge stands out thanks to the high throughput, wide variety, and excellent quality of obtained stand-alone nanomaterials, mainly core–shell nanoparticles, transition metal dichalcogenide monolayers, and carbon-based nanostructures, like graphene and carbon nanotubes. Unique capabilities of this arc technique are due to its flexibility and wide range of plasma parameters achievable by modulation of the frequency, duty cycle, and amplitude of pulse waveform. The many possibilities offered by pulsed arc discharges applied on synthesis of low-dimensional materials are reviewed here. Periodical variations in temperature and density of the pulsing arc plasma enable nanosynthesis with a more rational use of the supplied power. Parameters such as plasma composition, consumed power, process stability, material properties, and economical aspects, are discussed. Finally, a brief outlook towards future tendencies of nanomaterial preparation is proposed. Atmospheric pulsed arcs constitute promising, clean processes providing ecological and sustainable development in the production of nanomaterials both in industry and research laboratories.

Ground-based and airborne instrumentation for astronomy IX (2022), Montreal, JUL 17-22, 2022.--Proceedings of SPIE - The International Society for Optical Engineering vol. 12184 Article number 1218424.-- Complete list of authors: Marconi, A.; Abreu, M.; Adibekyan, V.; Alberti, V.; Albrecht, S.; Alcaniz, J.; Aliverti, M.; Allende Prieto, C.; Gomez, J. D. Alvarado; Amado, P. J.; Amate, M.; Andersen, M. I.; Artigau, E.; Baker, C.; Baldini, V.; Balestra, A.; Barnes, S. A.; Baron, F.; Barros, S. C. C.; Bauer, S. M.; Beaulieu, M.; Bellido-Tirado, O.; Benneke, B.; Bensby, T.; Bergin, E. A.; Biazzo, K.; Bik, A.; Birkby, J. L.; Blind, N.; Boisse, I.; Bolmont, E.; Bonaglia, M.; Bonfils, X.; Borsa, F.; Brandeker, A.; Brandner, W.; Broeg, C. H.; Brogi, M.; Brousseau, D.; Brucalassi, A.; Brynnel, J.; Buchhave, L. A.; Buscher, D. F.; Cabral, A.; Calderone, G.; Calvo-Ortega, R.; Cantalloube, F.; Canto Martins, B. L.; Carbonaro, L.; Chauvin, G.; Chazelas, B.; Cheffot, A. -L.; Cheng, Y. S.; Chiavassa, A.; Christensen, L.; Cirami, R.; Cook, N. J.; Cooke, R. J.; Coretti, I.; Covino, S.; Cowan, N.; Cresci, G.; Cristiani, S.; Cunha Parro, V.; Cupani, G.; D'Odorico, V.; de Castro Leao, I.; De Cia, A.; De Medeiros, J. R.; Debras, F.; Debus, M.; Demangeon, O.; Dessauges-Zavadsky, M.; Di Marcantonio, P.; Dionies, F.; Doyon, R.; Dunn, J.; Ehrenreich, D.; Faria, J. P.; Feruglio, C.; Fisher, M.; Fontana, A.; Fumagalli, M.; Fusco, T.; Fynbo, J.; Gabella, O.; Gaessler, W.; Gallo, E.; Gao, X.; Genolet, L.; Genoni, M.; Giacobbe, P.; Giro, E.; Goncalves, R. S.; Gonzalez, O. A.; Gonzalez Hernandez, J. I.; Gracia Temich, F.; Haehnelt, M. G.; Haniff, C.; Hatzes, A.; Helled, R.; Hoeijmakers, H. J.; Huke, P.; Jaervinen, A. S.; Jaervinen, S. P.; Kaminski, A.; Korn, A. J.; Kouach, D.; Kowzan, G.; Kreidberg, L.; Landoni, M.; Lanotte, A.; Lavail, A.; Li, J.; Liske, J.; Lovis, C.; Lucatello, S.; Lunney, D.; MacIntosh, M. J.; Madhusudhan, N.; Magrini, L.; Maiolino, R.; Malo, L.; Man, A. W. S.; Marquart, T.; Marques, E. L.; Martins, C. J. A. P.; Martins, A. M.; Maslowski, P.; Mason, E.; Mason, C. A.; McCracken, R. A.; Mergo, P.; Micela, G.; Mitchell, T.; Molliere, P.; Monteiro, M. A.; Montgomery, D.; Mordasini, C.; Morin, J.; Mucciarelli, A.; Murphy, M. T.; N'Diaye, M.; Neichel, B.; Niedzielski, A. T.; Niemczura, E.; Nortmann, L.; Noterdaeme, P.; Nunes, N. J.; Oggioni, L.; Oliva, E.; Onel, H.; Origlia, L.; Ostlin, G.; Palle, E.; Papaderos, P.; Pariani, G.; Penate Castro, J.; Pepe, F.; Levasseur, L. Perreault; Petit, P.; Pino, L.; Piqueras, J.; Pollo, A.; Poppenhaeger, K.; Quirrenbach, A.; Rauscher, E.; Rebolo, R.; Redaelli, E. M. A.; Reffert, S.; Reid, D. T.; Reiners, A.; Richter, P.; Riva, M.; Rivoire, S.; Rodriguez-Lopez, C.; Roederer, I. U.; Romano, D.; Rousseau, S.; Rowe, J.; Salvadori, S.; Sanna, N.; Santos, N. C.; Diaz, P. Santos; Sanz-Forcada, J.; Sarajlic, M.; Sauvage, J. -F.; Schaefer, S.; Schiavon, R. P.; Schmidt, T. M.; Selmi, C.; Sivanandam, S.; Sordet, M.; Sordo, R.; Sortino, F.; Sosnowska, D.; Sousa, S. G.; Stempels, E.; Strassmeier, K. G.; Suarez Mascareno, A.; Sulich, A.; Sun, X.; Tanvir, N. R.; Tenegi-Sangines, F.; Thibault, S.; Thompson, S. J.; Tozzi, A.; Turbet, M.; Vallee, P.; Varas, R.; Venn, K. A.; Veran, J. -P.; Verma, A.; Viel, M.; Wade, G.; Waring, C.; Weber, M.; Weder, J.; Wehbe, B.; Weingrill, J.; Woche, M.; Xompero, M.; Zackrisson, E.; Zanutta, A.; Zapatero Osorio, M. R.; Zechmeister, M.; Zimara, J., The first generation of ELT instruments includes an optical-infrared high resolution spectrograph, indicated as ELT-HIRES and recently christened ANDES (ArmazoNes high Dispersion Echelle Spectrograph). ANDES consists of three fibre-fed spectrographs (UBV, RIZ, YJH) providing a spectral resolution of similar to 100,000 with a minimum simultaneous wavelength coverage of 0.4-1.8 mu m with the goal of extending it to 0.35-2.4 mu m with the addition of a K band spectrograph. It operates both in seeing- and diffraction-limited conditions and the fibre-feeding allows several, interchangeable observing modes including a single conjugated adaptive optics module and a small diffraction-limited integral field unit in the NIR. Its modularity will ensure that ANDES can be placed entirely on the ELT Nasmyth platform, if enough mass and volume is available, or partly in the Coude room. ANDES has a wide range of groundbreaking science cases spanning nearly all areas of research in astrophysics and even fundamental physics. Among the top science cases there are the detection of biosignatures from exoplanet atmospheres, finding the fingerprints of the first generation of stars, tests on the stability of Nature's fundamental couplings, and the direct detection of the cosmic acceleration. The ANDES project is carried forward by a large international consortium, composed of 35 Institutes from 13 countries, forming a team of more than 200 scientists and engineers which represent the majority of the scientific and technical expertise in the field among ESO member states., The Italian effort for ANDES is supported by the Italian National Institute for Astrophysics (INAF). The Portuguese participation is supported by FCT -Fundacao para a Ciencia e a Tecnologia through national funds and by FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao by these grants: UID/FIS/04434/2019, UIDB/04434/2020 & UIDP/04434/2020; POCI-01-0145-FEDER-032113 & PTDC/FIS-AST/32113/2017. Swedish participation in the ANDES project is made possible through the national Swedish ELT Instrumentation Consortium (SELTIC), suppored by the Swedish Research Council (VR). CJM acknowledges FCT and POCH/FSE (EC) support through Investigador FCT Contract 2021.01214.CEECIND/CP1658/CT0001. JLB acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 805445. MTM acknowledges the support of the Australian Research Council through Future Fellowship grant FT180100194 SS acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 804240. TMS acknowledgment the support from the SNF synergia grant CRSII5-193689 (BLUVES), With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709

Atmospheric observations of mini-Neptunes orbiting M-dwarfs are beginning to provide constraints on their chemical and thermal properties, while also providing clues about their interiors and potential surfaces. With their relatively large scale heights and large planet-star contrasts, mini-Neptunes are currently ideal targets towards the goal of characterising temperate low-mass exoplanets. Understanding the thermal structures and spectral appearances of mini-Neptunes is important to understand various aspects of their atmospheres, including radiative/convective energy transport, boundary conditions for the interior, and their potential habitability. In the present study, we explore these aspects of mini-Neptunes using self-consistent models of their atmospheres. We begin by exploring the effects of irradiation, internal flux, metallicity, clouds and hazes on the atmospheric temperature profiles and thermal emission spectra of temperate mini-Neptunes. In particular, we investigate the impact of these properties on the radiative-convective boundary and the thermodynamic conditions in the lower atmosphere, which serves as the interface with the interior and/or a potential surface. Building on recent suggestions of habitability of the mini-Neptune K2-18 b, we find a range of physically-motivated atmospheric conditions that allow for liquid water under the H_2-rich atmospheres of such planets. We find that observations of thermal emission with JWST/MIRI spectrophotometry can place useful constraints on the habitability of temperate mini-Neptunes such as K2-18 b, and provide more detailed constraints on the chemical and thermal properties of warmer planets such as GJ 3470 b. Our results underpin the potential of temperate mini-Neptunes such as K2-18 b as promising candidates in the search for habitable exoplanets.

Ultra hot jupiters (UHJs), giant exoplanets with equilibrium temperatures above 2000 K, are ideal laboratories for studying metal compositions of planetary atmospheres. At these temperatures the thermal dissociation of metal-rich molecules into their constituent elements makes these atmospheres conducive for elemental characterisation. Several elements, mostly ionized metals, have been detected in UHJs recently using high resolution transit spectroscopy. Even though a number of neutral transition metals (e.g., Fe, Ti, V, Cr) are expected to be strong sources of optical/NUV opacity and, hence, influence radiative processes in the lower atmospheres of UHJs, only Fe I has been detected to date. We conduct a systematic search for atomic species in the UHJ WASP-121 b. Using theoretical models we present a metric to predict the atomic species likely to be detectable in such planets with high resolution transmission spectroscopy. We search for the predicted species in observations of WASP-121 b and report the first detections of neutral transition metals Cr I and V I in an exoplanet at 3.6 $\sigma$ and 4.5 $\sigma$, respectively. We confirm previous detections of Fe I and Fe II. Whereas Fe II was detected previously in the NUV, we detect it in the optical. We infer that the neutral elements Fe I, V I, and Cr I are present in the lower atmosphere, as predicted by thermochemical equilibrium, while Fe II is a result of photoionisation in the upper atmosphere. Our study highlights the rich chemical diversity of UHJs.

Funder: Science and Technology Facilities Council, UK, Funder: Gates Cambridge Trust, Exoplanets orbiting M-dwarfs present a valuable opportunity for their detection and atmospheric characterization. This is evident from recent inferences of H2O in such atmospheres, including that of the habitable-zone exoplanet K2-18b. With a bulk density between Earth and Neptune, K2-18b may be expected to possess a H/He envelope. However, the extent of such an envelope and the thermodynamic conditions of the interior remain unexplored. In the present work, we investigate the atmospheric and interior properties of K2-18b based on its bulk properties and its atmospheric transmission spectrum. We constrain the atmosphere to be H2-rich with a H2O volume mixing ratio of 0.02%–14.8%, consistent with previous studies, and find a depletion of CH4 and NH3, indicating chemical disequilibrium. We do not conclusively detect clouds/hazes in the observable atmosphere. We use the bulk parameters and retrieved atmospheric properties to constrain the internal structure and thermodynamic conditions in the planet. The constraints on the interior allow multiple scenarios between rocky worlds with massive H/He envelopes and water worlds with thin envelopes. We constrain the mass fraction of the H/He envelope to be ≲6%; spanning ≲10−5 for a predominantly water world to ∼6% for a pure iron interior. The thermodynamic conditions at the surface of the H2O layer range from the supercritical to liquid phases, with a range of solutions allowing for habitable conditions on K2-18b. Our results demonstrate that the potential for habitable conditions is not necessarily restricted to Earth-like rocky exoplanets.

We present the detection and analysis of the phase curve of KELT-1b at optical wavelengths, analyzing data taken by the Transiting Exoplanet Survey Satellite (TESS) during cycle 2 and sector 17. With a mass of similar to 27 M-Jup, KELT-1b is an example of a low-mass brown dwarf. Due to the high mass and close proximity of its companion, the host star exhibits a TESS light curve that shows clear ellipsoidal variations. We modeled the data with a six-component model: secondary eclipse, phase curve accounting for reflected light and thermal emission, Doppler beaming, ellipsoidal variations, stellar activity, and the primary transit. We determined the secondary eclipse depth in the TESS bandpass to be 304 +/- 75 parts-per-million (ppm). In addition, we measured the amplitude of the phase curve to be 128 +/- 27 ppm, with a corresponding eastward offset between the region of maximum brightness and the substellar point of 19.2 +/- 9.6 degrees, with the latter showing good agreement with Spitzer measurements. We determined a day-side brightness temperature in the TESS bandpass of 3201 +/- 147 K that is approximately 200 K higher than the values determined from the Spitzer 3.6 and 4.5 mu m data. By combining TESS and Spitzer eclipse depths, we derived a day-side effective temperature of T-eff = 3010 +/- 78 K. Previously published eclipse depths in the near-infrared suggest a much higher brightness temperature and this discrepancy cannot be explained by spectral models combined with the current data. We attribute those large eclipse depths to unmodeled ellipsoidal variations, which would typically be manifested as a deeper secondary eclipse in observations with insufficient phase coverage. A one-dimensional self-consistent atmospheric model is able to explain the TESS and Spitzer day-side brightness temperatures with thermal emission alone and no reflected light. The difference between the TESS and Spitzer brightness temperatures can be explained via CO absorption due to a non-inverted temperature profile. The night side data fix an upper limit of similar to 2000 K on the internal temperature of KELT-1 b.

Atmospheric compositions can provide powerful diagnostics of formation and migration histories of planetary systems. We investigate constraints on atmospheric abundances of H$_2$O, Na, and K, in a sample of transiting exoplanets using latest transmission spectra and new H$_2$ broadened opacities of Na and K. Our sample of 19 exoplanets spans from cool mini-Neptunes to hot Jupiters, with equilibrium temperatures between $\sim$300 and 2700 K. Using homogeneous Bayesian retrievals we report atmospheric abundances of Na, K, and H$_2$O, and their detection significances, confirming 6 planets with strong Na detections, 6 with K, and 14 with H$_2$O. We find a mass-metallicity trend of increasing H$_2$O abundances with decreasing mass, spanning generally substellar values for gas giants and stellar/superstellar for Neptunes and mini-Neptunes. However, the overall trend in H$_2$O abundances, from mini-Neptunes to hot Jupiters, is significantly lower than the mass-metallicity relation for carbon in the solar system giant planets and similar predictions for exoplanets. On the other hand, the Na and K abundances for the gas giants are stellar or superstellar, consistent with each other, and generally consistent with the solar system metallicity trend. The H$_2$O abundances in hot gas giants are likely due to low oxygen abundances relative to other elements rather than low overall metallicities, and provide new constraints on their formation mechanisms. The differing trends in the abundances of species argue against the use of chemical equilibrium models with metallicity as one free parameter in atmospheric retrievals, as different elements can be differently enhanced.

We present the detection and analysis of the phase curve of KELT-1b at optical wavelengths, analyzing data taken by the Transiting Exoplanet Survey Satellite (TESS). With a mass of ~27 M_J, KELT-1b is a low-mass brown dwarf. Due to the high mass and close proximity of its companion, the host star has a TESS light curve which shows clear ellipsoidal variations. We model the data with a six-component model: secondary eclipse, phase curve accounting for reflected light and thermal emission, Doppler beaming, ellipsoidal variations, stellar activity and the primary transit. We determine the secondary eclipse depth in the TESS bandpass to be 304 +/- 75 parts-per-million (ppm), the most accurate eclipse depth determined so far for KELT-1b. We measure the amplitude of the phase curve to be 128 +/- 27 ppm, with a corresponding eastward offset between the region of maximum brightness and the substellar point of 19.2 +/- 9.6 degrees, in good agreement with Spitzer measurements. We determine day and night brightness temperatures of 3201 +/- 147 K and 1484 +/- 110 K, respectively, slightly higher than those from Spitzer 3.6 and 4.5 micrometer data. A one-dimensional self-consistent atmospheric model can explain the TESS and Spitzer day side brightness temperatures with thermal emission alone and no reflected light. The night side data can be explained by a model with an internal temperature of ~1100 K, which may be related to the inflated radius. The difference between the TESS and Spitzer brightness temperatures can be explained by stronger molecular opacity in the Spitzer bands. On the night side, this opacity is due primarily to CH4 and CO while on the day side it is due to H2-H2 and H2-He collision-induced absorption., 18 pages, 12 figures

We report ground-based transmission spectroscopy of the highly irradiated and ultra-short period hot-Jupiter WASP-103b covering the wavelength range $\approx$ 400-600 nm using the FORS2 instrument on the Very Large Telescope. The light curves show significant time-correlated noise which is mainly invariant in wavelength and which we model using a Gaussian process. The precision of our transmission spectrum is improved by applying a common-mode correction derived from the white light curve, reaching typical uncertainties in transit depth of $\approx$ 2x10$^{-4}$ in wavelength bins of 15 nm. After correction for flux contamination from a blended companion star, our observations reveal a featureless spectrum across the full range of the FORS2 observations and we are unable to confirm the Na absorption previously inferred using Gemini/GMOS or the strong Rayleigh scattering observed using broad-band light curves. We performed a Bayesian atmospheric retrieval on the full optical-infrared transmission spectrum using the additional data from Gemini/GMOS, HST/WFC3 and Spitzer observations and recover evidence for H$_2$O absorption at the 4.0$\sigma$ level. However, our observations are not able to completely rule out the presence of Na, which is found at 2.0$\sigma$ in our retrievals. This may in part be explained by patchy/inhomogeneous clouds or hazes damping any absorption features in our FORS2 spectrum, but an inherently small scale height also makes this feature challenging to probe from the ground. Our results nonetheless demonstrate the continuing potential of ground-based observations for investigating exoplanet atmospheres and emphasise the need for the application of consistent and robust statistical techniques to low-resolution spectra in the presence of instrumental systematics.

Transmission spectroscopy of exoplanets has the potential to provide precise measurements of atmospheric chemical abundances, in particular of hot Jupiters whose large sizes and high temperatures make them conducive to such observations. To date, several transmission spectra of hot Jupiters have revealed low amplitude features of water vapour compared to expectations from cloud-free atmospheres of solar metallicity. The low spectral amplitudes in such atmospheres could either be due to the presence of aerosols that obscure part of the atmosphere or due to inherently low abundances of H$_2$O in the atmospheres. A recent survey of transmission spectra of ten hot Jupiters used empirical metrics to suggest atmospheres with a range of cloud/haze properties but with no evidence for H$_2$O depletion. Here, we conduct a detailed and homogeneous atmospheric retrieval analysis of the entire sample and report the H$_2$O abundances, cloud properties, terminator temperature profiles, and detection significances of the chemical species. Our present study finds that the majority of hot Jupiters have atmospheres consistent with sub-solar H$_2$O abundances at their day-night terminators. The best constrained abundances range from $\mathrm{log(H_2O)}$ of $-5.04^{+0.46}_{-0.30}$ to $-3.16^{+0.66}_{-0.69}$, which compared to expectations from solar-abundance equilibrium chemistry correspond to $0.018^{+0.035}_{-0.009}\times$ solar to $1.40^{+4.97}_{-1.11}\times$ solar. Besides H$_2$O we report statistical constraints on other chemical species and cloud/haze properties, including cloud/haze coverage fractions which range from $0.18^{+0.26}_{-0.12}$ to $0.76^{+0.13}_{-0.15}$. The retrieved H$_2$O abundances suggest sub-solar oxygen and/or super-solar C/O ratios, and can provide important constraints on the formation and migration pathways of hot giant exoplanets.

In this white paper, we recommend the European Space Agency plays a proactive role in developing a global collaborative effort to construct a large high-contrast imaging space telescope, e.g. as currently under study by NASA. Such a mission will be needed to characterize a sizable sample of temperate Earth-like planets in the habitable zones of nearby Sun-like stars and to search for extraterrestrial biological activity. We provide an overview of relevant European expertise, and advocate ESA to start a technology development program towards detecting life outside the Solar system.

Mycobacterium tuberculosis enoyl-ACP reductase (InhA) has been validated as a promising target for antitubercular agents. Isoniazid (INH), the most prescribed drug to treat tuberculosis (TB), inhibits a NADH-dependent InhA that provides precursors of mycolic acids, which are components of the mycobacterial cell wall. It is a pro-drug that needs activation to form the inhibitory INH-NAD adduct by KatG coding for catalase-peroxidase. The INH resistance of M. tuberculosis is caused by mutations in KatG, which may lead to multidrug-resistant TB (MDR-TB). Hence, there is a need for new drugs that can combat MDR-TB. The rationale for the development of new drugs to combat MDR-TB strains is the design of InhA inhibitors that can bypass bioactivation by KatG. In the present review, special attention was paid to discuss the chemical nature and recent developments of direct InhA inhibitors. The InhA inhibitors reported here have significant inhibitory effects against Mtb InhA. The diphenyl ether derivatives have shown slow onset, a tight-binding mechanism, and high affinity at the InhA active site. However, some of the diphenyl ethers have significant in vitro efficacy, which fails to transform into in vivo efficacy. Among the InhA inhibitors, 4-hydroxy-2-pyridones have emerged as a new chemical class with significant InhA inhibitory activity and better pharmacokinetic parameters when compared to diphenyl ethers.

Accurate estimations of atmospheric properties of exoplanets from transmission spectra require understanding of degeneracies between model parameters and observations that can resolve them. We conduct a systematic investigation of such degeneracies using a combination of detailed atmospheric retrievals and a range of model assumptions, focusing on H$_2$-rich atmospheres. As a case study, we consider the well-studied hot Jupiter HD 209458 b. We perform extensive retrievals with models ranging from simple isothermal and isobaric atmospheres to those with full pressure-temperature profiles, inhomogeneous cloud/haze coverage, multiple molecular species, and data in the optical-infrared wavelengths. Our study reveals four key insights. First, we find that a combination of models with minimal assumptions and broadband transmission spectra with current facilities allow precise estimates of chemical abundances. In particular, high-precision optical and infrared spectra along with models including variable cloud coverage and prominent opacity sources, Na and K being important in optical, provide joint constraints on cloud/haze properties and chemical abundances. Second, we show that the degeneracy between planetary radius and its reference pressure is well characterised and has little effect on abundance estimates, contrary to previous claims using semi-analytic models. Third, collision induced absorption due to H$_2$-H$_2$ and H$_2$-He interactions plays a critical role in correctly estimating atmospheric abundances. Finally, our results highlight the inadequacy of simplified semi-analytic models with isobaric assumptions for reliable retrievals of transmission spectra. Transmission spectra obtained with current facilities such as HST and VLT can provide strong constraints on atmospheric abundances of exoplanets., Accepted for publication in ApJ

© 2017. The American Astronomical Society. All rights reserved. Detecting the atmospheres of low-mass, low-temperature exoplanets is a high-priority goal on the path to ultimately detecting biosignatures in the atmospheres of habitable exoplanets. High-precision HST observations of several super-Earths with equilibrium temperatures below 1000 K have to date all resulted in featureless transmission spectra, which have been suggested to be due to high-altitude clouds. We report the detection of an atmospheric feature in the atmosphere of a 1.6 M⊕ transiting exoplanet, GJ 1132 b, with an equilibrium temperature of ∼600 K and orbiting a nearby M dwarf. We present observations of nine transits of the planet obtained simultaneously in the griz and JHK passbands. We find an average radius of 1.43 ±0.16 R⊕ for the planet, averaged over all the passbands, and a radius of 0.255 ±0.023 R⊙for the star, both of which are significantly greater than previously found. The planet radius can be decomposed into a "surface radius" at ∼1.375 R⊕ overlaid by atmospheric features that increase the observed radius in the z and K bands. The z-band radius is 4σ higher than the continuum, suggesting a strong detection of an atmosphere. We deploy a suite of tests to verify the reliability of the transmission spectrum, which are greatly helped by the existence of repeat observations. The large z-band transit depth indicates strong opacity from H2O and/or CH4 or a hitherto-unconsidered opacity. A surface radius of 1.375 ±0.16 R⊕ allows for a wide range of interior compositions ranging from a nearly Earth-like rocky interior, with ∼70% silicate and ∼30% Fe, to a substantially H2O-rich water world.

We present a high precision H-band emission spectrum of the transiting brown dwarf KELT-1b, which we spectrophotometrically observed during a single secondary eclipse using the LUCI1 multi-object spectrograph on the Large Binocular Telescope. Using a Gaussian-process regression model, we are able to clearly measure the broadband eclipse depth as Delta-H=1418+/-94ppm. We are also able to spectrally-resolve the H-band into five separate wavechannels and measure the eclipse spectrum of KELT-1b at R~50 with an average precision of +/-135ppm. We find that the day side has an average brightness temperature of 3250+/-50K, with significant variation as a function of wavelength. Based on our observations, and previous measurements of KELT-1b's eclipse at other wavelengths, we find that KELT-1b's day side appears identical to an isolated 3200K brown dwarf, and our modeling of the atmospheric emission shows a monotonically decreasing temperature-pressure profile. This is in contrast to hot Jupiters with similar day side brightness temperatures near 3000K, all of which appear to be either isothermal or posses a stratospheric temperature inversion. We hypothesize that the lack of an inversion in KELT-1b is due to its high surface gravity, which we argue could be caused by the increased efficiency of cold-trap processes within its atmosphere.

We report a detection of thermal emission from the hot Jupiter WASP-48b in the Ks-band. We used the Wide-field Infra-red Camera on the 3.6-m Canada-France Hawaii Telescope to observe an occultation of the planet by its host star. From the resulting occultation lightcurve we find a planet-to-star contrast ratio in the Ks-band of 0.136 ± 0.014%, in agreement with the value of 0.109 ± 0.027% previously determined. We fit the two Ks-band occultation lightcurves simultaneously with occultation lightcurves in the H-band and the Spitzer 3.6- and 4.5-μm bandpasses, radial velocity data, and transit lightcurves. From this, we revise the system parameters and construct the spectral energy distribution (SED) of the dayside atmosphere. By comparing the SED with atmospheric models, we find that both models with and without a thermal inversion are consistent with the data. We find the planet’s orbit to be consistent with circular (e < 0.072 at 3σ).

The James Webb Space Telescope (JWST) presents the opportunity to transform our understanding of planets and the origins of life by revealing the atmospheric compositions, structures, and dynamics of transiting exoplanets in unprecedented detail. However, the high-precision, time-series observations required for such investigations have unique technical challenges, and prior experience with other facilities indicates that there will be a steep learning curve when JWST becomes operational. In this paper we describe the science objectives and detailed plans of the Transiting Exoplanet Community Early Release Science (ERS) Program, which is a recently approved program for JWST observations early in Cycle 1. The goal of this project, for which the obtained data will have no exclusive access period, is to accelerate the acquisition and diffusion of technical expertise for transiting exoplanet observations with JWST, while also providing a compelling set of representative datasets that will enable immediate scientific breakthroughs. The Transiting Exoplanet Community ERS Program will exercise the time-series modes of all four JWST instruments that have been identified as the consensus highest priorities, observe the full suite of transiting planet characterization geometries (transits, eclipses, and phase curves), and target planets with host stars that span an illustrative range of brightnesses. The observations in this program were defined through an inclusive and transparent process that had participation from JWST instrument experts and international leaders in transiting exoplanet studies. Community engagement in the project will be centered on a two-phase Data Challenge that culminates with the delivery of planetary spectra, time-series instrument performance reports, and open-source data analysis toolkits in time to inform the agenda for Cycle 2 of the JWST mission.

© 2017 The Author(s). We present 16 occultation and three transit light curves for the ultra-short period hot Jupiter WASP-103b, in addition to five new radial velocity measurements. We combine these observations with archival data and perform a global analysis of the resulting extensive data set, accounting for the contamination from a nearby star. We detect the thermal emission of the planet in both the z' and KS bands, the measured occultation depths being 699±110 ppm (6.4σ) and 3567 -350 +400 ppm (10.2σ), respectively. We use these two measurements, together with recently published HST/WFC3 data, to derive joint constraints on the properties of WASP- 103b's dayside atmosphere. On one hand, we find that the z' band and WFC3 data are best fit by an isothermal atmosphere at 2900K or an atmosphere with a low H 2 O abundance. On the other hand, we find an unexpected excess in the K S band measured flux compared to these models, which requires confirmation with additional observations before any interpretation can be given. From our global data analysis, we also derive a broad-band optical transmission spectrum that shows a minimum around 700 nm and increasing values towards both shorter and longer wavelengths. This is in agreement with a previous study based on a large fraction of the archival transit light curves used in our analysis. The unusual profile of this transmission spectrum is poorly matched by theoretical spectra and is not confirmed by more recent observations at higher spectral resolution. Additional data, in both emission and transmission, are required to better constrain the atmospheric properties of WASP-103b.

© 2017. The American Astronomical Society. All rights reserved. Detecting the atmospheres of low-mass, low-temperature exoplanets is a high-priority goal on the path to ultimately detecting biosignatures in the atmospheres of habitable exoplanets. High-precision HST observations of several super-Earths with equilibrium temperatures below 1000 K have to date all resulted in featureless transmission spectra, which have been suggested to be due to high-altitude clouds. We report the detection of an atmospheric feature in the atmosphere of a 1.6 M⊕ transiting exoplanet, GJ 1132 b, with an equilibrium temperature of ∼600 K and orbiting a nearby M dwarf. We present observations of nine transits of the planet obtained simultaneously in the griz and JHK passbands. We find an average radius of 1.43 ±0.16 R⊕ for the planet, averaged over all the passbands, and a radius of 0.255 ±0.023 R⊙for the star, both of which are significantly greater than previously found. The planet radius can be decomposed into a "surface radius" at ∼1.375 R⊕ overlaid by atmospheric features that increase the observed radius in the z and K bands. The z-band radius is 4σ higher than the continuum, suggesting a strong detection of an atmosphere. We deploy a suite of tests to verify the reliability of the transmission spectrum, which are greatly helped by the existence of repeat observations. The large z-band transit depth indicates strong opacity from H2O and/or CH4 or a hitherto-unconsidered opacity. A surface radius of 1.375 ±0.16 R⊕ allows for a wide range of interior compositions ranging from a nearly Earth-like rocky interior, with ∼70% silicate and ∼30% Fe, to a substantially H2O-rich water world.

BACKGROUND AND OBJECTIVES: Cryptococcal meningitis is an important cause of mortality among HIV infected patients. A prospective study consisting of 106 HIV seropositive patients was undertaken to know the incidence of Cryptococcal meningitis, to correlate with CD4 count, to analyze the distribution of demographic factors like age, sex and symptoms and biochemical and cytological changes in cerebrospinal fluid. METHODS: CSF samples from HIV seropositive patients with suspected meningitis were subjected to Cytological and biochemical analysis. Latex agglutination test for antigen detection (LAT). CD4 cell count estimated by Flow cytometry. RESULTS: LAT was positive in 29(27.36%) patients. The incidence was highest (38.7%) in patients with CD4 count

Mycobacterium tuberculosis enoyl-ACP reductase (InhA) has been validated as a promising target for antitubercular agents. Isoniazid (INH), the most prescribed drug to treat tuberculosis (TB), inhibits a NADH-dependent InhA that provides precursors of mycolic acids, which are components of the mycobacterial cell wall. It is a pro-drug that needs activation to form the inhibitory INH-NAD adduct by KatG coding for catalase-peroxidase. The INH resistance of M. tuberculosis is caused by mutations in KatG, which may lead to multidrug-resistant TB (MDR-TB). Hence, there is a need for new drugs that can combat MDR-TB. The rationale for the development of new drugs to combat MDR-TB strains is the design of InhA inhibitors that can bypass bioactivation by KatG. In the present review, special attention was paid to discuss the chemical nature and recent developments of direct InhA inhibitors. The InhA inhibitors reported here have significant inhibitory effects against Mtb InhA. The diphenyl ether derivatives have shown slow onset, a tight-binding mechanism, and high affinity at the InhA active site. However, some of the diphenyl ethers have significant in vitro efficacy, which fails to transform into in vivo efficacy. Among the InhA inhibitors, 4-hydroxy-2-pyridones have emerged as a new chemical class with significant InhA inhibitory activity and better pharmacokinetic parameters when compared to diphenyl ethers.

Hydroxyzine is the first generation H1 receptor antagonist drug that is now marketed as a racemic mixture. The paper describes a validated enantioselective liquid chromatography method for the resolution of hydroxyzine enantiomers and cyclizine (internal standard) from 200 µL of rabbit plasma by liquid-liquid extraction technique using n-hexane and isopropanol. Hydroxyzine enantiomers were resolved at 10.2 and 11.1 min with good baseline resolution (Rs = 1.9) on a Lux amylose-2 chiral column (250 mm × 4.0 mm, 5 microns) at ambient room temperature. The mobile phase consisted of n-hexane-ethanol-diethylamine (90:10:0.1 v/v/v) pumped at 0.9 mL/min. The eluted enantiomers were detected at 254 nm. The linear calibration curve was constructed in the range 20-1000 ng/mL for both the (S)- and (R)-enantiomers. The intra- and inter-day precision were 0.16-2.6% and 0.2-1.92% for (S)-hydroxyzine and (R)-hydroxyzine, respectively. The method was successfully applied to determine the kinetic parameters of (S)- and (R)-hydroxyzine enantiomers in rabbits. The results illustrate that the disposition of hydroxyzine enantiomers is not stereoselective in rabbits.

Background: Enteric fever is classically caused by Salmonella enterica serotype Typhi. There has been increase in enteric fever cases from different parts of India caused by Salmonella enterica serotype Paratyphi A. Thereby a retrospective study was conducted to determine the rate of isolation and antimicrobial susceptibility pattern of Salmonella Paratyphi A in comparison to Salmonella Typhi. Methods: A retrospective analysis of laboratory records was carried out from January 2011-December 2014. Conventional blood culture method was used. Salmonella were confirmed by serotyping using group and type specific anti-sera. Antibiotic susceptibility was performed for ampicillin, cotrimoxazole, ciprofloxacin, chloramphenicol and ceftriaxone, using Kirby Bauers disk diffusion method. Results: Out of 258 Salmonella isolates, 127 (49.2 %) were Salmonella Typhi and 131 (50.8 %) were Salmonella Paratyphi A. Salmonella Paratyphi A cases increased from 23.4% in 2011-2013 to 91.3% in 2014. Salmonella Typhi were 98.4 % sensitive to ampicillin and ceftriaxone and 99.2% sensitive to chloramphenicol and cotrimoxazole. Only 29.9% were sensitive to ciprofloxacin. Similarly, Salmonella Paratyphi A isolates were 99.2 % sensitive to ampicillin and 100 % sensitive to cotrimoxazole and ceftriaxone and 96.9 % sensitive to chloramphenicol and only 14.5 % sensitive to ciprofloxacin.Conclusion: The present study confers Salmonella Paratyphi A as the rapidly emerging pathogen of enteric fever. The antibiogram of Salmonella Typhi and Salmonella Paratyphi A showed decreased susceptibility to fluoroquinolones and a notable decrease in the multi drug resistant strains of Salmonella isolates with re-emergence of susceptibility to first line antibiotics.

Mycobacterium tuberculosis enoyl-ACP reductase (InhA) has been validated as a promising target for antitubercular agents. Isoniazid (INH), the most prescribed drug to treat tuberculosis (TB), inhibits a NADH-dependent InhA that provides precursors of mycolic acids, which are components of the mycobacterial cell wall. It is a pro-drug that needs activation to form the inhibitory INH-NAD adduct by KatG coding for catalase-peroxidase. The INH resistance of M. tuberculosis is caused by mutations in KatG, which may lead to multidrug-resistant TB (MDR-TB). Hence, there is a need for new drugs that can combat MDR-TB. The rationale for the development of new drugs to combat MDR-TB strains is the design of InhA inhibitors that can bypass bioactivation by KatG. In the present review, special attention was paid to discuss the chemical nature and recent developments of direct InhA inhibitors. The InhA inhibitors reported here have significant inhibitory effects against Mtb InhA. The diphenyl ether derivatives have shown slow onset, a tight-binding mechanism, and high affinity at the InhA active site. However, some of the diphenyl ethers have significant in vitro efficacy, which fails to transform into in vivo efficacy. Among the InhA inhibitors, 4-hydroxy-2-pyridones have emerged as a new chemical class with significant InhA inhibitory activity and better pharmacokinetic parameters when compared to diphenyl ethers.

Pd-mediated cycloisomerization of 3-C-alkynyl-allo- and ribofuranose derivatives was investigated in detail to understand the influence of electronic factors on the regioselectivity in ring closure reaction. The reactions in general are influenced by the electronic nature of the substituent on the alkyne unit. A preference for endo-dig cyclization over exo-dig is noted, if the alkynyl substituent is not sufficiently electron withdrawing.

With the purpose of designing novel chemical entities with improved inhibitory potencies against drug-resistant Mycobacterium tuberculosis, the 3D- quantitative structure-activity relationship (QSAR) studies were carried out on biphenyl analogs of the tuberculosis (TB) drug, PA-824. Anti-mycobacterial activity (MABA) was considered for the 3D-QSAR studies using the comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) approaches. The best CoMFA and CoMSIA models were found statistically significant with cross-validated coefficients (q(2)) of 0.784 and 0.768, respectively, and conventional coefficients (r(2)) of 0.823 and 0.981, respectively. The cross-validated and the external validation results revealed that both the CoMFA and CoMSIA models possesses high accommodating capacities and they would be reliable for predicting the pMIC values of new PA-824 derivatives. Based on the models and structural insights, a series of new PA-824 derivatives were designed and the anti-mycobacterial activities of the designed compounds were predicted based on the best 3D-QSAR model. The predicted data results suggest the designed compounds are more potent than existed ones.

We report near-infrared spectroscopy of the gas giant planet HD 189733b in transit. We used the Hubble Space Telescope Wide Field Camera 3 (HST WFC3) with its G141 grism covering 1.1 um to 1.7 um and spatially scanned the image across the detector at 2\arcsec$s^{-1}$. When smoothed to 75 nm bins, the local maxima of the transit depths in the 1.15 um and 1.4 um water vapor features respectively are 83+/-53 ppm and 200+/-47 ppm greater than the local minimum at 1.3 um. We compare the WFC3 spectrum with the composite transit spectrum of HD 189733b assembled by Pont et al. (2013), extending from 0.3 um to 24 um. Although the water vapor features in the WFC3 spectrum are compatible with the model of non-absorbing, Rayleigh-scattering dust in the planetary atmosphere (Pont et al. 2013), we also re-interpret the available data with a clear planetary atmosphere. In the latter interpretation, the slope of increasing transit depth with shorter wavelengths from the near infrared, through the visible and into the ultraviolet is caused by unocculted star spots, with a smaller contribution of Rayleigh scattering by molecular hydrogen in the planet's atmosphere. At relevant pressures along the terminator, our model planetary atmosphere's temperature is ~700 K, which is below the condensation temperatures of sodium- and potassium-bearing molecules, causing the broad wings of the spectral lines of Na I and K I at 0.589 um and 0.769 um to be weak., 14 pages, 5 figures, Accepted to ApJ

We present new warm Spitzer occultation photometry of WASP-26 at 3.6��m and 4.5��m along with new transit photometry taken in the g,r and i bands. We report the first detection of the occultation of WASP-26b, with occultation depths at 3.6��m and 4.5��m of 0.00126 +/- 0.00013 and 0.00149 +/- 0.00016 corresponding to brightness temperatures of 1825+/-80K and 1725+/-89K, respectively. We find that the eccentricity of the orbit is consistent with a circular orbit at the 1�� level with a 3�� upper limit of e < 0.04. According to the activity-inversion relation of Knutson et al. (2010), WASP-26b is predicted to host a thermal inversion. The brightness temperatures deduced from the eclipse depths are consistent with an isothermal atmosphere, although it is within the uncertainties that the planet may host a weak thermal inversion. The data are equally well fit by atmospheric models with or without a thermal inversion. We find that variation in activity of solar-like stars does not change enough over the time-scales of months or years to change the interpretation of the Knutson et al. (2010) activity-inversion relation, provided that the measured activity level is averaged over several nights. Further data are required to fully constrain the thermal structure of the atmosphere because the planet lies very close to the boundary between atmospheres with and without a thermal inversion., 11 Pages,8 Figures,5 Tables, Accepted for Publication in MNRAS

Aims. We observe occultations of WASP-24b to measure brightness temperatures and to determine whether or not its atmosphere exhibits a thermal inversion (stratosphere). Methods. We observed occultations of WASP-24b at 3.6 and 4.5 ��m using the Spitzer Space Telescope. It has been suggested that there is a correlation between stellar activity and the presence of inversions, so we analysed existing HARPS spectra in order to calculate log R'HK for WASP-24 and thus determine whether or not the star is chromospherically active. We also observed a transit of WASP-24b in the Str��mgren u and y bands, with the CAHA 2.2-m telescope. Results. We measure occultation depths of 0.159 \pm 0.013 per cent at 3.6 ��m and 0.202 \pm 0.018 per cent at 4.5 ��m. The corresponding planetary brightness temperatures are 1974 \pm 71 K and 1944 \pm 85 K respectively. Atmosphere models with and without a thermal inversion fit the data equally well; we are unable to constrain the presence of an inversion without additional occultation measurements in the near-IR. We find log R'HK = -4.98 \pm 0.12, indicating that WASP-24 is not a chromospherically active star. Our global analysis of new and previously-published data has refined the system parameters, and we find no evidence that the orbit of WASP-24b is non-circular. Conclusions. These results emphasise the importance of complementing Spitzer measurements with observations at shorter wavelengths to gain a full understanding of hot Jupiter atmospheres., 7 pages, 4 figures, 3 tables. Accepted for publication in A&A

We present here the results of our observations of TrES-2 using the Infrared Array Camera on Spitzer. We monitored this transiting system during two secondary eclipses, when the planetary emission is blocked by the star. The resulting decrease in flux is 0.127% ± 0.021%, 0.230% ± 0.024%, 0.199% ± 0.054%, and 0.359% ± 0.060% at 3.6 μm, 4.5 μm, 5.8 μm, and 8.0 μm, respectively. We show that three of these flux contrasts are well fit by a blackbody spectrum with T_(eff) = 1500 K, as well as by a more detailed model spectrum of a planetary atmosphere. The observed planet-to-star flux ratios in all four IRAC channels can be explained by models with and without a thermal inversion in the atmosphere of TrES-2, although with different atmospheric chemistry. Based on the assumption of thermochemical equilibrium, the chemical composition of the inversion model seems more plausible, making it a more favorable scenario. TrES-2 also falls in the category of highly irradiated planets which have been theoretically predicted to exhibit thermal inversions. However, more observations at infrared and visible wavelengths would be needed to confirm a thermal inversion in this system. Furthermore, we find that the times of the secondary eclipses are consistent with previously published times of transit and the expectation from a circular orbit. This implies that TrES-2 most likely has a circular orbit, and thus does not obtain additional thermal energy from tidal dissipation of a non-zero orbital eccentricity, a proposed explanation for the large radius of this planet.

Two stereocontrolled approaches towards a precursor of 1 β-methylthienamycin, have been accomplished by involving stereospecific hydrogenation of 13 and stereoselective hydroboration oxidation of 9. The latter compounds were obtained from the easily accessible chiral building block 7. The hydroboration-oxidation approach was extended to 18 in which the optically active 1R- (1-hydroxy ethyl) side-chain was incorporated. The highly stereoselective hydroboration-oxidation reaction of 9 is explained by considering Houk's models.

We investigate the evolution of the properties of model populations of ultraluminous X-ray sources (ULXs) consisting of a black-hole accretor in a binary with a donor star. We have computed models corresponding to two different. populations of black-hole binaries: one invokes stellar-mass (similar to 10 M-circle dot) black hole accretors(1) (LMBHs), and the second utilizes intermediate-mass (similar to 1000M(circle dot)) black holes (IMBHs). For each of the two populations, we computed 30,000 binary evolution sequences using a full Henyey stellar evolution code. The optical flux from the model ULXs includes contributions from the donor star and the accretion disk (the latter being due to X-ray irradiation as well as intrinsic viscous heating). We present. "probability images" for the ULX systems in planes of color-magnitude, orbital period vs. X-ray luminosity, and luminosity vs. evolution time. Estimates of the numbers of ULXs in a typical galaxy as a function of X-ray luminosity are also presented. Our model CMDs are compared with six ULX counterparts that have been discussed in the literature. Overall, the observed systems seem more closely related to model systems with very high-mass donors (greater than or similar to 25 M-circle dot) in binaries with IMBH accretors. However, significant difficulties remain with both the IMBH and stellar-mass black hole models.

Background & objectives: Infection is an important cause of morbidity and mortality in surgical patients. Surgical site infections can occur anytime from zero to thirty days and affect either the incision or deep tissue at the operation site. Rapidly emerging nosocomial pathogens and the problem of multi-drug resistance necessitates periodic review of isolation patterns and sensitivity in surgical practice. This study aimed at evaluating the incidence of SSI in our hospital and the preventive measures which are already practised for reducing the SSI rate in our hospital.Materials & methods: A hospital based descriptive study conducted in a public tertiary care hospital in Puducherry. Data from 242 surgical patients were collected using a predesigned proforma and the patients were followed up for a period of 30 days following surgery to assess the occurrence of any infection at wound site.Results: During the study period data from 242 patients were collected. Out of these, 29 patients [12%] developed the surgical site infection. The incidence of SSI in clean surgeries was 11.1% and in clean-contaminated surgeries was 12.9%. The most common isolates were Staphylococcus aureus and MRSA [2 cases each] and all other isolates were obtained from single cases of SSI.Interpretation & conclusions: The incidence of SSI in our institute was found to be around 12% in clean & clean-contaminated surgeries. The pathogenic isolates from our institute were same as pathogens associated with SSI from other studies.

OBJECTIVE:To determine the baseline Widal titre in apparently healthy adult population of Hubli-Dharwad (North Karnataka region), which is an endemic area for enteric fever.METHODS:Two hundred healthy volunteers involving women attending ANC clinics, students, doctors and health care personnel were screened for Salmonella agglutinins using Widal test. Widal titres were estimated by tube agglutination method & slide semi quantitative method.RESULTS:A total of 154(77%) individuals revealed antibody titre to common O antigen. One hundred and seventy two (86%) had anti H titre & 68(34%) had anti AH titre of S.enterica. subsp. enterica. ser.Typhi & Paratyphi A respectively. Geometric mean of the observed readings were 38.58 for O, 60.37 for H & 40.02 for AH antibody. Result of slide semiquantitative & tube agglutination test were in agreement with each other. No significant difference was observed in the baseline titre among general population and health care providers.CONCLUSION: Based on these findings antibody titre of 1:40 for O, 1:80 for H & 1:40 for AH antigen considered as baseline titre in this region. Updated data on the basal antibody titres in various regions is essential to decide the cut off level for interpretation of the Widal test and proper diagnosis of Enteric fever.

Broad absorption signatures from alkali metals, such as the sodium (Na I) and potassium (K I) resonance doublets, have long been predicted in the optical atmospheric spectra of cloud-free irradiated gas giant exoplanets1-3. However, observations have revealed only the narrow cores of these features rather than the full pressure-broadened profiles4-6. Cloud and haze opacity at the day-night planetary terminator are considered to be responsible for obscuring the absorption-line wings, which hinders constraints on absolute atmospheric abundances7-9. Here we report an optical transmission spectrum for the 'hot Saturn' exoplanet WASP-96b obtained with the Very Large Telescope, which exhibits the complete pressure-broadened profile of the sodium absorption feature. The spectrum is in excellent agreement with cloud-free, solar-abundance models assuming chemical equilibrium. We are able to measure a precise, absolute sodium abundance of logεNa = [Formula: see text], and use it as a proxy for the planet's atmospheric metallicity relative to the solar value (Zp/Zʘ = [Formula: see text]). This result is consistent with the mass-metallicity trend observed for Solar System planets and exoplanets10-12.

Recent detections of thermal inversions in the dayside atmospheres of some hot Jupiters are motivating new avenues to understand the interplay between their temperature structures and other atmospheric conditions. In particular, TiO has long been proposed to cause thermal inversions in hot Jupiters, depending on other factors such as stellar irradiation, C/O, and vertical mixing. TiO also has spectral features in the optical and near-infrared that have been detected. However, interpretations of TiO signatures rely on the accuracy of TiO opacity used in the models. The recently reported Toto TiO line list provides a new opportunity to investigate these dependencies, which is the goal of the present work. First, we investigate how the Toto line list affects observable transmission and emission spectra of hot Jupiters at low and high resolution. The improvement in the Toto line list compared to a previous line list results in observable differences in the model spectra, particularly in the optical at high resolution. Secondly, we explore the interplay between temperature structure, irradiation and composition with TiO as the primary source of optical opacity, using 1D self-consistent atmospheric models. Among other trends, we find that the propensity for thermal inversions due to TiO peaks at C/O$\sim$0.9, consistent with recent studies. Using these models, we further assess metrics to quantify thermal inversions due to TiO, compared to frequently-used Spitzer photometry, over a range in C/O, irradiation, metallicity, gravity and stellar type.

We present an optical-to-infrared transmission spectrum of the inflated sub-Saturn KELT-11b measured with the Transiting Exoplanet Survey Satellite (TESS), the Hubble Space Telescope (HST) Wide Field Camera 3 G141 spectroscopic grism, and the Spitzer Space Telescope (Spitzer) at 3.6 $\mu$m, in addition to a Spitzer 4.5 $\mu$m secondary eclipse. The precise HST transmission spectrum notably reveals a low-amplitude water feature with an unusual shape. Based on free retrieval analyses with varying molecular abundances, we find strong evidence for water absorption. Depending on model assumptions, we also find tentative evidence for other absorbers (HCN, TiO, and AlO). The retrieved water abundance is generally $\lesssim 0.1\times$ solar (0.001--0.7$\times$ solar over a range of model assumptions), several orders of magnitude lower than expected from planet formation models based on the solar system metallicity trend. We also consider chemical equilibrium and self-consistent 1D radiative-convective equilibrium model fits and find they too prefer low metallicities ($[M/H] \lesssim -2$, consistent with the free retrieval results). However, all the retrievals should be interpreted with some caution since they either require additional absorbers that are far out of chemical equilibrium to explain the shape of the spectrum or are simply poor fits to the data. Finally, we find the Spitzer secondary eclipse is indicative of full heat redistribution from KELT-11b's dayside to nightside, assuming a clear dayside. These potentially unusual results for KELT-11b's composition are suggestive of new challenges on the horizon for atmosphere and formation models in the face of increasingly precise measurements of exoplanet spectra.

We investigate a new class of habitable planets composed of water-rich interiors with massive oceans underlying H2-rich atmospheres, referred to here as Hycean worlds. With densities between those of rocky super-Earths and more extended mini-Neptunes, Hycean planets can be optimal candidates in the search for exoplanetary habitability and may be abundant in the exoplanet population. We investigate the bulk properties (masses, radii, and temperatures), potential for habitability, and observable biosignatures of Hycean planets. We show that Hycean planets can be significantly larger compared to previous considerations for habitable planets, with radii as large as 2.6 Earth radii (2.3 Earth radii) for a mass of 10 Earth masses (5 Earth masses). We construct the Hycean habitable zone (HZ), considering stellar hosts from late M to sun-like stars, and find it to be significantly wider than the terrestrial-like HZ. While the inner boundary of the Hycean HZ corresponds to equilibrium temperatures as high as ~500 K for late M dwarfs, the outer boundary is unrestricted to arbitrarily large orbital separations. Our investigations include tidally locked `Dark Hycean' worlds that permit habitable conditions only on their permanent nightsides and `Cold Hycean' worlds that see negligible irradiation. Finally, we investigate the observability of possible biosignatures in Hycean atmospheres. We find that a number of trace terrestrial biomarkers which may be expected to be present in Hycean atmospheres would be readily detectable using modest observing time with the James Webb Space Telescope (JWST). We identify a sizable sample of nearby potential Hycean planets that can be ideal targets for such observations in search of exoplanetary biosignatures.

Atmospheric retrievals of exoplanetary transmission spectra provide important constraints on various properties such as chemical abundances, cloud/haze properties, and characteristic temperatures, at the day-night atmospheric terminator. To date, most spectra have been observed for giant exoplanets due to which retrievals typically assume H-rich atmospheres. However, recent observations of mini-Neptunes/super-Earths, and the promise of upcoming facilities including JWST, call for a new generation of retrievals that can address a wide range of atmospheric compositions and related complexities. Here we report Aurora, a next-generation atmospheric retrieval framework that builds upon state-of-the-art architectures and incorporates the following key advancements: a) a generalised compositional retrieval allowing for H-rich and H-poor atmospheres, b) a generalised prescription for inhomogeneous clouds/hazes, c) multiple Bayesian inference algorithms for high-dimensional retrievals, d) modular considerations for refraction, forward scattering, and Mie-scattering, and e) noise modeling functionalities. We demonstrate Aurora on current and/or synthetic observations of hot Jupiter HD209458b, mini-Neptune K218b, and rocky exoplanet TRAPPIST1d. Using current HD209458b spectra, we demonstrate the robustness of our framework and cloud/haze prescription against assumptions of H-rich/H-poor atmospheres, improving on previous treatments. Using real and synthetic spectra of K218b, we demonstrate the agnostic approach to confidently constrain its bulk atmospheric composition and obtain precise abundance estimates. For TRAPPIST1d, 10 JWST NIRSpec transits can enable identification of the main atmospheric component for cloud-free CO$_2$-rich and N$_2$-rich atmospheres, and abundance constraints on trace gases including initial indications of O$_3$ if present at enhanced levels ($\sim$10-100x Earth levels).

Optical transmission spectroscopy provides crucial constraints on the reference pressure levels and scattering properties for hot Jupiter atmospheres. For certain planets, where alkali atoms are detected in the atmosphere, their line profiles could serve as a good probe to link upper and lower atmospheric layers. WASP-21b is a Saturn-mass hot Jupiter orbiting a thick disc star, with a low density and an equilibrium temperature of 1333 K, which makes it a good target for transmission spectroscopy. Here, we present a low-resolution transmission spectrum for WASP-21b based in one transit observed by the OSIRIS spectrograph at the 10.4 m Gran Telescopio Canarias (GTC), and a high-resolution transmission spectrum based in three transits observed by HARPS-N at Telescopio Nazinale Galileo (TNG) and HARPS at the ESO 3.6 m telescope. We performed spectral retrieval analysis on GTC's low-resolution transmission spectrum and report the detection of Na at a confidence level of $>$3.5-$\sigma$. The Na line exhibits a broad line profile that can be attributed to pressure broadening, indicating a mostly clear planetary atmosphere. The spectrum shows a tentative excess absorption at the K D$_1$ line. Using HARPS-N and HARPS, we spectrally resolved the Na doublet transmission spectrum. An excess absorption at the Na doublet is detected during the transit, and shows a radial velocity shift consistent with the planet orbital motion. We proposed a metric to quantitatively distinguish hot Jupiters with relatively clear atmospheres from others, and WASP-21b has the largest metric value among all the characterized hot Jupiters. The detection of Na at both lower and upper atmosphere of WASP-21b reveals that it is an ideal target for future follow-up observations, providing the opportunity to understand the nature of its atmosphere across a wide range of pressure levels.

We present 16 occultation and three transit light curves for the ultra-short period hot Jupiter WASP-103b, in addition to five new radial velocity measurements. We combine these observations with archival data and perform a global analysis of the resulting extensive data set, accounting for the contamination from a nearby star. We detect the thermal emission of the planet in both the z' and Ks bands, the measured occultation depths being 699±110 ppm (6.4σ) and 3567+⁴⁰⁰−₃₅₀ ppm (10.2σ), respectively. We use these two measurements, together with recently published HST/WFC3 data, to derive joint constraints on the properties of WASP-103b's dayside atmosphere. On one hand, we find that the z' band and WFC3 data are best fit by an isothermal atmosphere at 2900 K or an atmosphere with a low H2O abundance. On the other hand, we find an unexpected excess in the Ks band measured flux compared to these models, which requires confirmation with additional observations before any interpretation can be given. From our global data analysis, we also derive a broad-band optical transmission spectrum that shows a minimum around 700 nm and increasing values towards both shorter and longer wavelengths. This is in agreement with a previous study based on a large fraction of the archival transit light curves used in our analysis. The unusual profile of this transmission spectrum is poorly matched by theoretical spectra and is not confirmed by more recent observations at higher spectral resolution. Additional data, in both emission and transmission, are required to better constrain the atmospheric properties of WASP-103b.

Transmission spectroscopy provides a powerful probe of the atmospheric properties of transiting exoplanets. To date, studies of exoplanets in transit have focused on inferring their atmospheric properties such as chemical compositions, cloud/haze properties, and temperature structures. However, surface inhomogeneities in the host stars of exoplanets in the form of cool spots and hot faculae can in principle imprint signatures on the observed planetary transit spectrum. Here we present Aura, a new retrieval paradigm for inferring both planetary and stellar properties from a transmission spectrum. We apply our retrieval framework to a sample of hot giant exoplanets to determine the significance of stellar heterogeneity and clouds/hazes in their spectra. The retrieval analyses distinguish four groups of planets. First, the spectra of WASP-6b and WASP-39b are best characterised by imprints of stellar heterogeneity and hazes and/or clouds. HD 209458b and HAT-P-12b comprise the second group for which there is weak evidence for stellar heterogeneity and a high significance of hazes and/or clouds. The third group constitutes HAT-P-1b and WASP-31b and shows weak evidence against stellar heterogeneity but weak to substantial indications of clouds/hazes. The fourth group -- WASP-19b, WASP-17b, and WASP-12b -- is fit best by molecular and alkali absorbers with H$_2$ scattering without evidence for stellar heterogeneity and weak to no evidence for clouds/hazes. Our retrieval methodology paves the way to simultaneous information on the star and planet from higher resolution spectra using future facilities such as the James Webb Space Telescope and large ground-based facilities.

Observations of exoplanetary spectra are leading to unprecedented constraints on their atmospheric elemental abundances, particularly O/H, C/H, and C/O ratios. Recent studies suggest that elemental ratios could provide important constraints on formation and migration mechanisms of giant exoplanets. A fundamental assumption in such studies is that the chemical composition of the planetary envelope represents the sum-total of compositions of the accreted gas and solids during the formation history of the planet. We investigate the efficiency with which accreted planetesimals ablate in a giant planetary envelope thereby contributing to its composition rather than sinking to the core. From considerations of aerodynamic drag causing `frictional ablation' and the envelope temperature structure causing `thermal ablation', we compute mass ablations for impacting planetesimals of radii 30 m to 1 km for different compositions (ice to iron) and a wide range of velocities and impact angles, assuming spherical symmetry. Icy impactors are fully ablated in the outer envelope for a wide range of parameters. Even for Fe impactors substantial ablation occurs in the envelope for a wide range of sizes and velocities. For example, iron impactors of sizes below ~0.5 km and velocities above ~30 km/s are found to ablate by ~60-80% within the outer envelope at pressures below 10^3 bar due to frictional ablation alone. For deeper pressures (~10^7 bar), substantial ablation happens over a wider range of parameters. Therefore, our exploratory study suggests that atmospheric abundances of volatile elements in giant planets reflect their accretion history during formation.