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Crack consumption is a major public health issue in Martinique with a poor prognosis. A preliminary study has found a high prevalence of history of childhood ADHD (C-ADHD) in crack users.To determine the prevalence of C-ADHD and adult ADHD (A-ADHD) in crack users and their potential associations with substance use behavior.All consecutive patients consulting in the public academic hospital covering 376,000 inhabitants were included in the present study and received a comprehensive battery measuring addictive behavior, psychiatric and somatic comorbidities. C-ADHD groups and A-ADHD groups were defined with the Wender-Utah Rating Scale-25 and the Brown ADD Rating Scale, respectively. Impulsivity was evaluated with the Barratt Impulsiveness Scale (BIS-11).In total, 111 participants were evaluated. Among them, 50 (45%) were classified in the C-ADHD group and 20 (18%) in the A-ADHD group. Compared to the patients without ADHD, those with ADHD were found to have higher impulsivity (C-ADHD: BIS total score 67.90 (10.1) vs. 63.28 (10.5), P=0.021, BIS attentional score 17.5 (3.6) vs. 15.3 (3.4), P=0.002, A-ADHD: BIS total score 75.1 (11.3) vs. 63.4 (9.2), P0.001, BIS motor impulsivity 26.9 (5.3) vs. 22.6 (4.3), P0.001, BIS attentional score 19.3 (3.3) vs. 15.6 (3.5), P0.001, BIS planification 28.9 (5.7) vs. 25.10 (4.7), P=0.003). Fifty percent of A-ADHD patients were found with high impulsivity vs. 15% of patients without A-ADHD (P0.001). However, ADHD was not associated with more severe addictive behavior or history of legal consequences.ADHD prevalence is high in cocaine-crack users and associated with increased impulsivity. However, neither ADHD nor impulsivity explains addictive behaviors or legal consequences.

A água é um dos recursos naturais mais importantes no planeta e até bem pouco tempo era considerado como um bem infinito. A realização do monitoramento espaço-sazonal das características físicas, químicas e microbiológicas dos corpos hídricos contribui na avaliação ambiental, pois se trata de atividade estratégica relevante para a conservação e gestão destes ecossistemas. Para avaliar a qualidade das águas do Igarapé Santos, as campanhas amostrais foram realizadas no período chuvoso (abril) e no período de estiagem (agosto), sendo as coletas distribuídas em seis pontos: zona rural (P1, P2), zona de transição/rural-urbano (P3) e zona urbana (P4, P5, P6). Foram coletadas amostras de água de superfície (15-30 cm) e avaliadas as características de qualidade da água (físico-química e microbiológica), através dos parâmetros: cor, temperatura, turbidez, pH, CE, sólidos totais em suspensão, ferro, fósforo total, nitrito, nitrato, amônia, coliformes totais e escherichia coli. Verificou-se que nos períodos sazonais, STS (17630 – 37957 mg/L), ferro (0,80 – 0,98 mg/L), fósforo total (0,31 – 0,82 mg/L), coliformes totais (2300 – 10.000 ufc/mL) e e-coli (1080 – 7250 ufc/mL) estão superiores ao Valor Máximo Permitido (VMP) pela Resolução CONAMA nº 357/05 para o enquadramento de corpos d’água nível classe 2. O grupo de parâmetros de qualidade da água no período chuvoso (p = 0,0000629) e de estiagem (p = 0,0000353) obtiveram-se médias heterogêneas, refletindo a influência da sazonalidade amazônica sob a qualidade das águas deste igarapé. Assim, o prosseguimento aos estudos é de fundamental importância para avaliação contínua da qualidade hídrica da bacia hidrográfica do Igarapé Santos.

There has been a continuous interest in multi-robot formation systems in the last few years due to several significant advantages such as robustness, scalability, and efficiency. However, multi-robot formation systems suffer from well-known problems such as energy consumption, processing speed, and security. Therefore, developers are continuously researching for optimal solutions that can gather the benefits of multi-robot formation systems while overcoming the possible challenges. A backbone process required by any multi-robot system is path planning. Thus, path planning for multi-robot systems is a recent top research topic. However, the literature lacks a recent comprehensive review of path planning works designed for multi-robot systems. The aim of this review paper is to provide a comprehensive assessment and an insightful look into various path planning techniques developed in multi-robot formation systems, in addition to highlighting the basic problems involved in this field. This will allow the reader to discover the research gaps that must be solved for a better path planning experience for multi-robot formation systems. Finally, an illustrative comparative example is presented at the end of the paper to show the advantages and disadvantages of some popular path planning techniques.

Feature Selection (FS) for Sentiment Analysis (SA) becomes a complex problem because of the large-sized learning datasets. However, to reduce the data dimensionality, researchers have focused on FS using swarm intelligence approaches that reflect the best classification performance. Crocodiles Hunting Strategy (CHS), a novel swarm-based meta-heuristic that simulates the crocodiles’ hunting behaviour, has demonstrated excellent optimization results. Hence, in this work, two FS algorithms, i.e., Binary CHS (BCHS) and Improved BCHS (IBCHS) based on original CHS were applied for FS in the SA field. In IBCHS, the opposition-based learning technique is applied in the initialization and displacement phases to enhance the search space exploration ability of the IBCHS. The two proposed approaches were evaluated using six well-known corpora in the SA area (Semeval-2016, Semeval-2017, Sanders, Stanford, PMD, and MRD). The obtained result showed that IBCHS outperformed BCHS regarding search capability and convergence speed. The comparison results of IBCHS to several recent state-of-the-art approaches show that IBCHS surpassed other approaches in almost all used corpora. The comprehensive results reveal that the use of OBL in BCHS greatly impacts the performance of BCHS by enhancing the diversity of the population and the exploitation ability, which improves the convergence of the IBCHS.

International audience; BACKGROUND: Lung-protective ventilation (reduced tidal volume and limited plateau pressure) may lead to CO(2) retention. Data about the impact of hypercapnia in patients with ARDS are scarce and conflicting. METHODS: We performed a non-interventional cohort study with subjects with ARDS admitted from 2006 to 2021 and with P(aO(2)) /F(IO(2)) ≤ 150 mm Hg. We examined the association between severe hypercapnia (P(aCO(2)) ≥ 50 mm Hg) on the first 5 days after the diagnosis of ARDS and death in ICU for 930 subjects. All the subjects received lung-protective ventilation. RESULTS: Severe hypercapnia was noted in 552 subjects (59%) on the first day of ARDS (day 1); 323/930 (34.7%) died in the ICU. Severe hypercapnia on day 1 was associated with mortality in the unadjusted (odds ratio 1.54, 95% CI 1.16-1.63; P = .003) and adjusted (odds ratio 1.47, 95% CI 1.08-2.43; P = .004) models. In the Bayesian analysis, the posterior probability that severe hypercapnia was associated with ICU death was > 90% in 4 different priors, including a septic prior for this association. Sustained severe hypercapnia on day 5, defined as severe hypercapnia present from day 1 to day 5, was noted in 93 subjects (12%). After propensity score matching, severe hypercapnia on day 5 remained associated with ICU mortality (odds ratio 1.73, 95% CI 1.02-2.97; P = .047). CONCLUSIONS: Severe hypercapnia was associated with mortality in subjects with ARDS who received lung-protective ventilation. Our results deserve further evaluation of the strategies and treatments that aim to control CO(2) retention.

Since their appearance, machining techniques have undergone multiple improvements. The processes of shaping materials by removing material have been constantly questioned in order to stay in step with industrial requirements, whatever economic or ecological. Today, the manufacturing engineer must therefore be able to answer a multitude of questions in order to quickly produce parts of the required quality and at low cost. Hard turning is a process that can be described as standard in a number of sectors such as the production of bearing steel 100Cr6 chrome with a hardness of 62 RC, but also turning auto parts steel chromium-manganese cemented hardened gears as 27MnCr5 a hardness of 62 RC. The technical and economic feasibility of machining parts such harshness was made possible thanks to the use of new tool materials with a very high hardness and high chemical stability at high temperatures, such as cubic boron nitride CBN, and with the arrival of new machine tools with significant stability and high precision. Hard turning allows today to produce high-quality surfaces from competing in many cases, operations traditionally reserved for rectification. High speed machining has also showed its competitiveness in applications such as turning parts for gearboxes and drivesystems in hardened materials. This article is a contribution to the study of the integrity of the machined surface in hard turning.

Fe2AlB2 is one of many ternary transition metal borides called MAB phases, which attracted interest owing to its magnetocaloric effect and magnetic properties. Herein, the molten salt shielded synthesis (MS3) of Fe2AlB2 powder is studied using potassium bromide “KBr” in an open-air atmosphere. The synthesis process of the MAB phase, from Fe, Al, and B elemental powders, was studied with and without Sn additive in the temperature range of 900–1200°C. The obtained powders were analyzed using XRD, TDA, GTA and SEM analysis. The corresponding results revealed a successful synthesis of nearly-pure Fe2AlB2 phase at 1000°C for only one hour of holding time, beyond which FeB impurities form. These results show the efficiency of KBr (with Sn as a synthesis aid ‘additive’) in increasing the reactivity of this MAB phase in terms of the lowest synthesis temperature and time reported to date.

The powder of Mn-Zn ferrite having the chemical formula Mn(1-x)ZnxFe2O4 where x varies from 0, 0.1, 0.2, 0.3, 0.4, and 0.5 were synthesized by solid state Reaction method. The X-Ray Diffraction studies confirm the formation of spinel cubic structure. The particle size was calculated by X-ray broadening studies. Also the structural parameters like Lattice Constant, X-ray density, bulk density (d), Porosity (P), ionic radius (Ra , Rb) and anion parameter or the oxygen positional parameter for all the samples. The micro structural features of the samples were obtained using a Scanning Electron Microscopy (SEM). The magnetic properties of Mn(1-x)ZnxFe2O4 ferrites were strongly affected by the Zn content. The saturation magnetization increased. It may be due to relatively high orbital contribution of Mn2+ ions to magnetic moment, which gives large induced anisotropy.

BackgroundThis study aimed to compare ventilatory parameters recorded in the first days of acute respiratory distress syndrome (ARDS) and mortality at day 60 between coronavirus disease 2019 (COVID-19) and influenza ARDS patients with arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FIO2) ≤150 mmHg.MethodsWe compared 244 COVID-19 ARDS patients with 106 influenza ARDS patients. Driving pressure, respiratory system compliance (Crs), ventilator ratio, corrected minute ventilation (V′Ecorr) and surrogate of mechanical power (index=(4×driving pressure)+respiratory rate) were calculated from day 1 to day 5 of ARDS. A propensity score analysis and a principal component analysis (PCA) were performed.ResultsOn day 1 of ARDS, COVID-19 patients had significantly higherPaO2/FIO2(median (interquartile range) 97 (79–129.2)versus83 (62.2–114) mmHg; p=0.001), and lower driving pressure (13.0 (11.0–16.0)versus14.0 (12.0–16.7) cmH2O; p=0.01), ventilatory ratio (2.08 (1.73–2.49versus2.52 (1.97–3.03); pV′Ecorr(12.7 (10.2–14.9)versus14.9 (11.6–18.6) L·min−1; pversus84 (75–94); p=0.004). PCA demonstrated an important overlap of ventilatory parameters recorded on day 1 between the two groups. From day 1 to day 5, repeated values ofPaO2/FIO2, arterial carbon dioxide tension, ventilatory ratio andV′Ecorrdiffered significantly between influenza and COVID-19 patients in the unmatched and matched populations. Mortality at day 60 did not differ significantly after matching (29%versus21.7%; p=0.43).ConclusionsVentilation was more impaired in influenza than in COVID-19 ARDS patients on the first day of ARDS with an important overlap of values. However, mortality at day 60 did not differ significantly in the matched population.

In this article, we investigate the existence of unique maximal and minimal solutions for a coupled differential system in terms of generalized fractional derivative with arbitrary order. The iterative technique of a fixed point operator together with the properties of green's function are used basically. Moreover, we investigate the generalized Ulam-Hyers stability of the solution for the given coupled system. Finally, some examples are given to illustrate the theoretic results.

In the current study, natural convection is numerically simulated in a shallow, porous, square cavity that is filled with a non-Newtonian fluid. In terms of temperature and concentration gradients (heat and mass fluxes), the active wall was seen as uniform and constant, whereas the other walls are adiabatic and impermeable. To analyze the behavior of shear-thinning fluids, a Carreau-Yasuda model is utilized, which is suitable for many non-Newtonian fluids. It is presummated that the fluid will fulfill the Boussinesq approximation, be laminar, and be incompressible.

The main objective of this study was to identify carbapenem resistance mechanisms among clinical, commensal and environmental carbapenem-resistant Acinetobacter baumannii (CRAB) strains isolated in 5 Tunisian intensive care units (ICUs).CRAB isolates were recovered from different sources: clinical specimens, rectal and environmental swabs. Bacterial identification was carried out using conventional methods and susceptibility testing according to EUCAST recommendations. Evaluation of phenotypic carbapenemase production of was performed using seven different methods, and molecular detection of carbapenemase-coding genes (blaAll in all, 46 CRAB isolates were identified in clinical specimens (n = 26/26), rectal swabs (n = 17/36) and environmental swabs (n = 3/63). Most of them (n = 41/46) were clonally related and found in the different ICUs. All of the CARB isolates harbored blaThe emergence and diffusion of clonal CRAB strains inducing high mortality rates in ICUs is a major public health concern. Enhanced infection control practices and mandatory staff education are needed to control the spread of these multidrug-resistant bacteria.

In this work we deal with a uniqueness result of solutions for a class of fractional differential equations involving the Caputo-Fabrizio derivative. We provide a result on the global convergence of successive approximations.

Fifty-six brands of bottled water marketed on the Algerian market are the subject of this study.Hydrochemical classification and statistical distribution based on multivariate analysis usingappropriate tools were used to analyze data reported on bottled water labels. These waters weretogether into groups with similarities in terms of chemical characteristics and mineral content. Theresults obtained offer consumers a simple tool for assessing the differences between bottled waters,as to the choice of water to acquire.

Background: Invasive fungal infections are a major cause of death in pediatric oncology, especially among patients under chemotherapy. This study aims to identify risk factors for invasive fungal infections in pediatric oncology. Methods: We conducted a monocentric retrospective case-control multi-cohort study on a population of 30 patients with malignant hemopathies or solid cancers under chemotherapy, admitted in the Pediatric Oncology unit of Nafissa Hammoud Hospital in Algiers, amongst which 24 patients were controls, and 6 patients were cases. Results: In a total of 30 patients (53.3 % male), 13 patients developed a fever, from which 6 patients were identified as invasive fungal infection cases according to the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and Infectious Diseases Mycoses Study Group (EORTC/MSG) guidelines, with an incidence of 20 %. The mean age was 7.47 years old at the admission date. Four statistically significant risk factors were identified (p-value < 0.05, CI 95 %): mucositis with an odds ratio (OR) at 10 (1,34 – 74,51), the most aggressive chemotherapy protocol according to the ITR2 with an OR at 115 (6,10 – 2165,95), severe prolonged neutropenia with an OR at 7,6 (1,07 – 54,09) and severe prolonged lymphopenia with an OR at 25 (2,27 – 275,71). Conclusion: Many conditions were identified as risk factors for invasive fungal infections in pediatric oncology, especially severe lymphopenia and aggressive chemotherapy. These patients may have to receive close monitoring or even antifungal prophylaxis.

This paper discusses the design and development of cyber-physical, social systems using a set of guidelines that capture the conceptual and technical characteristics of such systems. These guidelines are packaged into a framework that resorts to the concept of artifact. Because of these characteristics, the framework’s artifacts are specialized into 3 types referred to as data, thing, and social, all connected together through a set of situational relations referred to as work-withme, work-for-me, back-me, and avoid-me. To mitigate conflicts blue that could arise because of artifacts’ respective time availabilities when they jointly participate in situational relations, policies are put in place defining who does what, when, where, and why. To demonstrate the technical doability of the multi-type artifact framework, a system capturing cyber, physical, and social interactions in a healthcare case-study is developed, deployed, and evaluated.

Sentiment analysis has received constant research attention due to its usefulness and importance in different applications. However, despite the research advances in this field, most current tools suffer in prediction quality due to the inconsistencies in their results, i.e., intra- and inter-tool inconsistencies. This demonstration proposes a system for the evaluation of sentiment analysis quality namely SA-Q. The system allows the evaluation of inconsistency in sentiment analysis tools, the resolution of the inconsistency using state-of-the-art methods and the recommendation of relevant sentiment analysis tool for any type of data set provided by the attendees. It allows the attendees to compare the tools. Moreover, we demonstrate that SA-Q evaluates the consistency of tools on two levels (intra-tool and inter-tool). Through various scenarios, we showcase the challenges of inconsistency resolution, demonstrate the usefulness of the proposed system and the recommendations that can be given to the attendees for their datasets. We demonstrate that SA-Q system has practical utility in many areas of industrial applications for better decision making. This demonstration shows promising research areas for data management, NLP, and machine learning communities by adopting and drawing inspiration from truth inference methods to create more robust tools and improve the tool's scalability.

In addition to the difficulty of system modeling, every physical system faces actuator saturation, making the real control different from the controller output (desired control input). When this occurs, the controller output does not regulate the system properly and errors occur as a result of incorrect updating. This is known as the windup phenomenon. In the event that the controller is configured to override actuator saturation, it can lead to a failure in the controller’s performance, such as large overshoots, high response time, and even system instability in the worst case. Therefore, in this paper, a new robust model-free controller method is proposed. It is a combination of four nonlinear control techniques, namely model-free controller, fractional-order sliding mode controller, fractional integral–proportional (PI) controller, and anti-windup compensator, which gives rise to the new model-free controller algorithm called hybrid fractional-order intelligent PI fractional sliding mode controller with an anti-windup compensator termed (MF-FOiPI-FOSMC-AW). However, to illustrate the effectiveness of the new proposed MF-FOiPI-FOSMC-AW method, simulation and experimental results compared to classical PI and iPI controllers (with and without an anti-windup compensator) on a hydraulic system are presented in the presence or absence of external disturbances for different types of references. Finally, simulation is conducted through an experimental comparison of the proposed approach with other strategies such as the classical anti-windup PI controller and the anti-windup intelligent PI controller, which is carried out for this purpose.

Studying the relationship between the Soil Moisture Index (SMI) and climate change is crucial, as it provides insights into the impacts of changing climatic conditions on soil moisture dynamics and hydrological processes. Our main objective in this study is to evaluate soil moisture variations in the El Mefrouche watershed in northwestern Algeria, based on changes in climatic parameters such as precipitation and temperature over a period of five years. To achieve this objective, we will use Landsat 8 satellite.images for each year of the study period. The study uses a Soil Moisture Index (SMI) to analyze satellite images taken on five different dates. The results show that on 02/01/2019, the soil moisture was very high (SMI from 0.8 to 1) covering an area of 309.67 hectares, whereas on 12/30/2017, the soil moisture was very low (SMI from 0.8 to 1) covering only an area of 65.46 hectares. The driest SMI values (0 to 0.2) were recorded on 12/30/2017, covering the largest area of 1809.37 hectares, indicating that the soil was very dry in a large part of the watershed. What is really confirmed after analyzing the climatic data for the cited period.

This work investigates the boundary value problem (BVP) of impulsive differential equations (DEs) with a nonlinear ρ−Caputo fractional and p-Laplacian operator. To prove the existence and uniqueness of solutions, we employ Schauder’s and Schaefer’s fixed point theorems, along with the Banach contraction principle. Additionally, we present two examples to show the practical applications and significance of our main results. Our study provides a new perspective on impulsive DEs with fractional and p–Laplacian operators and contributes to the development of the theory of impulsive DEs. AMS Subject Classi cation: Primary 34A08; 34B15; secondary 34B27

Background/Aims Behçet’s syndrome (BS) is a multi-systemic vasculitis highly prevalent in a broad range stretching from the Mediterranean region to eastern Asia. The vascular involvement, present in up to 40% of the cases, is characterised by a high tendency towards the venous system and thrombosis. Although pulmonary artery aneurysms (PAA) are considered to be rare (less than 5% in cohorts), they are a quasi-pathognomonic sign of BS and play a major role in patient’s morbidity and long-term mortality. Our work aims to depict the clinical profile, imaging features, therapeutic management, and outcomes of BS patients presenting with PAA. Methods We conducted a retrospective, descriptive and monocentric study including 531 BS patients admitted to the internal medicine department between 2000 and 2021. All patients fulfilled the International Study Group Criteria for Behçet’s disease. We enrolled all cases with documented PAA on CT angiography of the chest (CTA chest). Results Among 531 BS patients, 51 had PAA (10%). The mean age was 36 ± 11 [20-69] and the sex ratio (M:F) was 4:1. Cardiovascular risk factors comprised chronic tobacco consumption (13.5%) and high blood pressure (9.6%). PAA occurred after a median of 5.5 years following the disease onset. Patients were either asymptomatic (78%) or presented with hemoptysis (6%), dry cough (6%), chest pain (4%), and dyspnea (2%). On CTA chest, PAA were commonly multiple (78%), proximal (46%), and bilateral (29%). Concomitant arterial manifestations were observed in 25% of the patients, consisting of peripheral arteries aneurysms (17%), pulmonary artery thrombosis (7.7%), cerebral artery thrombosis (4%), and aortic aneurysms (2%). Venous thrombosis was also simultaneously found in 21% of the cases, observed in the superior (9.6%) and inferior vena cava (9.6%), cerebral veins (7.7%), and lower extremity veins (6%). On echocardiography, right intracardiac thrombosis was visualised (17%). The other extravascular involvements were mainly mucocutaneous (73%), ocular (46%), articular (29%), and neurological (10%). Our patients were treated with colchicine (100%) and an initial pulse of methylprednisolone (15mg/kg/day for three days), followed by oral prednisolone (1 mg/kg/day), gradually tapered (94%). The immunosuppressive therapy administered consisted of cyclophosphamide (38.5%), azathioprine (31%), and infliximab, a TNF alpha inhibitor (2%). Curative anticoagulation was prescribed in 21% of the cases. Only one patient underwent surgery. Relapse and death were recorded in respectively 15% and 6% of the cases. Conclusion PAA are a very unique feature of BS, with specific characteristics related to their inflammatory pathogenesis. We highly recommend evoking the diagnosis of BD in presence of PAA, especially in young male patients presenting with other vascular lesions and intracardiac thrombosis. The prompt initiation of anti-inflammatory and immunosuppressive therapy is of paramount importance to reduce the risk of massive hemorrhage from PAA rupture. Disclosure S. Chadli: None. H. Khibri: None. S. Fari Firdaous: None. N. Moatassim: None. W. Ammouri: None. M. Maamar: None. H. Harmouche: None. M. Adnaoui: None. Z. Tazi Mezalek: None.

Background/Aims Amyloidosis is a broad spectrum of heterogeneous diseases, characterized by the accumulation and extracellular deposit of misfolded proteins, resulting in organs’ thickening and dysfunction. Cardiac amyloidosis (CA) is common and represents an important key factor in patients’ prognosis. Our study aims to depict the profile of patients with CA, so as present their therapeutic management and outcomes. Methods We retrospectively carried out a descriptive study between 2015 and 2022, including all patients admitted to our department for systemic amyloidosis (SA) with confirmed cardiac involvement on echocardiography (TTE) and/or cardiac magnetic resonance (CMR). Results 31 patients were enrolled. The sex ratio (M/F) was 0.93 and the mean age was 62 ± 15 years (26-86). Past history included multiple myeloma (n = 7), monoclonal gammapathy of undetermined significance (n = 1), T lymphoma (n = 1), and systemic amyloidosis (n = 1). Cardiovascular risk factors comprised high blood pressure (25%), type 2 diabetes (15%), dyslipidemia (9%), and smoking (8%). Patients presented after a mean of 12 ± 4 months since the onset, with peripheral edema (68%) and other signs of right (53%) and global heart failure (19%). Concomitant extracardiac involvements were mainly renal (55%), mucocutaneous (20%), and neurological (16%). Electrocardiogram showed low-voltage (41%), poor R-wave progression (23%), atrial fibrillation (10%), atrioventricular block (6%), right bundle branch block (6%), left bundle branch block (6%), junctional tachycardia (6%), and left ventricular hypertrophy (LVH) (6%). On TTE, the features observed were the altered longitudinal global strain (93%) with a bull’s eye pattern (90%), LVH (90%), valvular and septal hypertrophy (88%), sparkling myocardium (65%), pericardial effusion (54%), diastolic dysfunction (37%), dilated cavities (35%), pulmonary hypertension (29%), and aortic stenosis (3%). Systolic function was mostly conserved (73%), at a mean of 53 ± 10%. The most recurrent signs on CMR were: late enhancement (90%), LVH (80%), and abnormalities in myocardium nulling (25%). Cardiac biomarkers included a Troponin of 0.35 ng/ml [0.13; 506] and BNP of 4895 pg/ml [1588; 13 224]. BS showed positive cardiac fixation (grade 2 or 3) in six cases, confirming ATTR-CA. Peripheral biopsies, serum and urine immunofixation, free light chains assays, and medullar investigations demonstrated AL in 23 patients. Two cases of AA were confirmed on immunohistochemistry, complicating sarcoidosis (n = 1) and ankylosing spondylitis (n = 1). Patients were treated with chemotherapy (n = 11), Tafamidis (n = 3), and Infliximab (n = 2). The outcomes documented were complete remission (n = 1), partial remission (n = 3), and death (n = 9) with a median survival of 7 months. Conclusion Our study highlights the grim prognosis still carried by CA patients. Although increased awareness is noticed among physicians, the disease is often discovered at a late stage or even overlooked. Further understanding of CA and prompt screening of at-risk patients are thus crucial for early diagnosis and management, in order to improve patients' outcomes. Disclosure S. Chadli: None. M. Maamar: None. H. Khibri: None. N. Moatassim: None. W. Ammouri: None. H. Harmouche: None. M. Adnaoui: None. Z. Tazi Mezalek: None.

Background/Aims Behçet’s disease (BD) is a relapsing vasculitis that can affect vessels of all sizes and kinds. Intracardiac thrombosis (ICT) is a rare but serious complication which often presents with vascular lesions. Yet, the link between these manifestations is not fully clarified. Our study aims to describe the profile, therapeutic management, and outcomes of BD patients with ICT. Secondly, it aims to shed some light on the relationship between ICT and vascular involvement in BD. Methods We retrospectively conducted a descriptive and monocentric study, including 531 Behçet’s patients admitted to our department between 2010 and 2022. All patients selected fulfilled the criteria of the International Study Group of Behçet’s Disease. Results Twelve patients were enrolled (2%). The sex ratio (M:F) was 9:1 and the mean age was 29 ± 6 years (20-41). ICT occurred as the revealing form of BD (50%), or after a median of 4 years since the disease onset (50%). The main symptoms were dyspnea (58%), chest pain (58%), hemoptysis (41%), and dry cough (33%). Concurrent BD flares were mainly mucocutaneous (80%). Inflammatory parameters were elevated with a median ESR of 48 mm/h and CRP of 52 mg/L. High levels of BNP and troponin were noted in 58% and 16% of the cases. Hemostasis parameters were within the normal range. On transthoracic echocardiogram, ICT was located in the right (100%), and left cavities (20%), with an extension to the inferior vena cava in half of the cases (50%). Multiple thrombi were visualized (n = 4). The associated cardiac lesions were tricuspid insufficiency (50%), pericardial effusion (41%), mitral insufficiency (16%), endomyocardial fibrosis (8%), myocarditis (8%), and ischemic coronaropathy (8%). Pulmonary hypertension (58%) and right dilatation (50%) were common. Concomitant pulmonary artery involvement was frequent (83%), consisting of thrombosis (70%) and aneurysms (50%). Six patients had a past history of lower extremity DVT, either as a single episode (n = 4) or recurrent episodes (n = 2). Vascular thrombosis was also found in the superior vena cava (n = 2), suprahepatic veins (n = 2), internal jugular vein (n = 1), pulmonary veins (n = 1), cerebral vein (n = 1), superior mesenteric vein (n = 1), and femoral artery (n = 1). Patients were treated with colchicine (100%), glucocorticoids (100%), and immunosuppressants (92%), mainly cyclophosphamide (n = 11), and a TNF-alpha inhibitor (n = 2). Six patients were under curative anticoagulation. A good response to therapy was observed in all patients. One case of relapse was reported. No deaths were recorded. Conclusion ICT usually occurs during the first years of BD onset in young male patients presenting with vascular lesions, especially of the pulmonary arteries and vena cava. We thus believe that, unlike common thrombotic diseases, ICT in BD is a direct consequence of the underlying vasculitis. The use of immunosuppressants, with or without anticoagulants, is generally associated with a favorable outcome. Disclosure S. Chadli: None. H. Khibri: None. S. Fari: None. N. Moatassim: None. W. Ammouri: None. M. Maamar: None. H. Harmouche: None. M. Adnaoui: None. Z. Tazi Mezalek: None.

Background/Aims Behçet’s syndrome (BS) is a complex inflammatory disorder frequently observed in the so-called “Silk Road”. Venous thrombosis (VT) is common in BS and known to be a predictive factor of future severe manifestations of the disease. Our work aims to describe the clinical and imaging characteristics of VT in BS, in order to shed the light on its specific features for early diagnosis and management of these patients. Methods We conducted a retrospective, descriptive and monocentric study, including 200 BS patients admitted to our internal medicine department between 2014 and 2021. All patients fulfilled the International Study Group criteria for Behçet’s disease. Results VT was found in 62 patients (31%). The mean age was 29 ± 10.8 (18-61) and the sex ratio (M:F) was 7.85:1. Family history of BS was documented in 5% of the cases. VT was either the revealing manifestation of the syndrome (56%) or occurred after a median of 3.5 years (1; 6.5) following the disease onset. Four patients had superficial venous thrombosis (SVT) mostly affecting the superficial femoral vein (98%). All patients had deep vein thrombosis (DVT), visualised in the lower extremities (58%), superior vena cava (21%), inferior vena cava (16%), cerebral veins (13%), and suprahepatic veins (5%). Atypical sites of DVT occurred in the renal (n = 1), axillary (n = 1), central retinal (n = 1), and dorsal penile (n = 1) veins. DVT was observed in one vein (55%), two veins (27%), or multiple (3 to 7) veins (16%). Thrombi sizes ranged from 10 to 40 mm, being willingly extended (55%) and strongly adherent to the vessel walls (95%). Concomitant arterial lesions were found in 34% of the patients, mainly in the pulmonary arteries (57%). They consisted of aneurysms (52%), thrombosis (43%), stenosis (17%), and pseudoaneurysms (9%). Cardiac lesions were also observed (11%), including right intracardiac thrombosis (n = 4), coronary artery thrombosis (n = 2), pericarditis (n = 1), and myocarditis (n = 1). The other extravascular involvements associated were mucocutaneous (100%), ocular (42%), neurological (29%), articular (24%), and digestive (23%). Fever was reported in 4 cases. All patients were treated with colchicine and glucocorticoids. Immunosuppressive therapy was prescribed in 75% of the cases: cyclophosphamide (n = 31), azathioprine (n = 12), and TNF alpha inhibitor (n = 3). Curative anticoagulation was also administered (98%). Two patients underwent surgery: thrombectomy (n = 1) and embolectomy (n = 1). Relapse occurred in 27% of the patients. No death was recorded. Conclusion VT is widely considered to be the hallmark of BS as well as a major risk factor for future severe vascular and cardiac involvements. Due to its inflammatory pathogenesis, it has specific clinical and imaging features. Better knowledge of these characteristics could help early establish the diagnosis of BS, thus improving patient outcomes. Disclosure S. Chadli: None. H. Khibri: None. R. Benachour: None. S. Firdaous Fari: None. N. Moatassim: None. W. Ammouri: None. M. Maamar: None. H. Harmouche: None. M. Adnaoui: None. Z. Tazi Mezalek: None.

Traditional butter is widely used in pastoral populations in Algeria, thanks to its nutritional value. Several studies have investigated traditional butter produced in Algeria, our study is a contribution to its improvement and valorisation through the phenotypic identification and characterization of lactic acid bacteria responsible for the fermentation of this product. The samples were collected in the regions of Relizane, Oran, Sidi Bel-Abbes and Tindouf. Physicochemical tests make it possible to specify the quality of traditional butter; the pH is 4.5 ± 0.02 to 5.31 ± 0.2, the fat content is 73 ± 0.2 to 83 ± 0.1%, the acid index is 28.05 ± 0.2 to 44.88 ± 0.2 mg KOH.g-1 and the saponification index is 131.85 ± 0.2 to 359.10 ± 0.2 mg KOHg.-1. The microbiological analysis results show that the lactic microflora isolated from butter consists mainly of different genera; Lactobacillus 49%, Lactococcus 20%, Leuconostoc 15%, Enterococcus 11% and Pediococcus 5%. Species identification is based on classical phenotypic characterization; Lb. plantarum 7 isolates (26%), Lb. casei subsp. casei 6 isolates (22%), Lb. casei subsp. rhamnosus and Lb. delbrueckii subsp. bulgaricus 5 isolates (19%), Lb. delbrueckii subsp. delbrueckii 4 isolates (14%), Lc. lactis subsp. cremoris 6 isolates (55%), Lc. lactis subsp. lactis 5 isolates (45%), Ln. mesenteroides subsp. dextranicum 5 isolates (62%), Ln. mesenteroides subsp. mesenteroides 3 isolates (38%), E. faecalis 4 isolates (67%), E. faecium 2 isolates (33%), P. acidilactici3 isolates (100%). They have considerable biotechnological characteristics which allow the constitution of specific starters in the manufacture of Algerian traditional butter.