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1. Hastanemiz Nedeni Bilinmeyen Ateş Olgularının Değerlendirilmesi

Author

Aslan, Turan, Yüce, Nurgül, Meriç Koç, Meliha, Durdu, Bülent, Akkoyunlu, Yasemin, Okay, Gülay, AKKOYUNLU, YASEMİN, DURDU, BÜLENT, OKAY, GÜLAY, MERİÇ KOÇ, MELİHA, YÜCE, NURGÜL, and ASLAN, TURAN

Subjects
Yüce N., Meriç Koç M., Okay G., Durdu B., Akkoyunlu Y., Aslan T., -Hastanemiz Nedeni Bilinmeyen Ateş Olgularının Değerlendirilmesi-, 22. TÜRK KLİNİK MİKROBİYOLOJİ VE İNFEKSİYON HASTALIKLARI KONGRESİ, Antalya, Türkiye, 9 - 12 Mart 2022, ss.376-377
Published
2022

2. Investigation of the predictive value of MuLBSTA score in predicting critical clinical outcomes in hospitalized patients with severe acute respiratory syndromecoronavirus-2 pneumonia

Author

YEŞİLTAŞ, Serdar, MERİÇ KOÇ, Meliha, KARATAŞ, Ayşe, TEPE, Gülpınar, PASİN, Ozge, PASİN, ÖZGE, TEPE, GÜLPINAR, and YEŞİLTAŞ, SERDAR

Subjects
COVID-19, erken uyarı skorları, MuLBSTA skoru, qSOFA, early warning score, MuLBSTA score, Health Care Sciences and Services, YEŞİLTAŞ S., Koç M. M. , KARATAŞ A., TEPE G., PASİN Ö., -Investigation of the predictive value of MuLBSTA score in predicting critical clinical outcomes in hospitalized patients with severe acute respiratory syndromecoronavirus-2 pneumonia-, ANATOLIAN CLINIC JOURNAL OF MEDICAL SCIENCES, cilt.27, sa.3, ss.311-317, 2022, Sağlık Bilimleri ve Hizmetleri
Abstract

Amaç: Multilobar infiltrasyon, lenfositopeni, bakteriyel koenfeksiyon, sigara öyküsü, hipertansiyon ve yaş>65 (MuLBSTA) skoru, viral pnömonisi olan hastaları beklenen mortaliteye göre sınıflandırmak için kullanılan bir klinik tahmin kuralıdır. Hastanede yatan SARS-CoV-2 hastalarında kötü klinik sonuçlar için MuLBSTA’nın prediktif performansını PSI, CURB-65 ve qSOFA ile karşılaştırdık.Yöntemler: Bu çalışma 11 Mart 2020 ile 31 Mayıs 2020 tarihleri arasında üçüncü basamak bir üniversite hastanesinde yatan SARS-CoV-2’li hastalar üzerinde geriye dönük yapıldı. SARS-CoV-2 testi pozitif çıkan 900 hastadan 271’i çalışmaya dâhil edildi. Tüm hastalarda 30 günlük mortalite, Yoğun bakım ünitesi (YBÜ) ihtiyacı, mekanik ventilasyon gereksinimi ve akut respiratuar distress (ARDS) gelişimini değerlendirmek için MuLBSTA, PSI, CURB-65 ve qSOFA skoru kullanıldı. Otuz günlük mortalite için prognostik faktörler de analiz edildi.Bulgular: Hastanede yatan 271 hastanın 150’si (%55.3) erkekti. Ortalama yaş 54.2±15.4 yıldı. Otuz günlük ölüm oranı %10,7 idi. Çalışmaya dâhil edilen hastalardan; 39 hasta (%14,3) YBÜ’ye yatırıldı, 32 hasta (%11,8) mekanik ventilatör desteği aldı ve 23 hasta (%8,4) ARDS tanısı aldı. Mortaliteyi tahmin etmede MuLBSTA, PSI, CURB-65 ve qSOFA skorlarının eğri altında kalan alan (AUC) değerleri sırasıyla 0.877 (%95 CI 0.832 0.914), 0.853 (%95 CI 0.806-0.893), 0.769 (95% CI 0,714-0,817) ve 0,769 (95% CI 0,715-0,818). MuLBSTA puanı, diğer tahmin puanlarına kıyasla daha yüksek bir AUC değeri gösterdi. MuLBSTA ve PSI skorları, YBÜ ihtiyacı, mekanik ventilasyon gereksinimive ARDS gelişimi olan hastaları belirlemede CURB-65 ve qSOFA skorlarından daha iyi performans gösterdi.Sonuç: MuLBSTA skoru, hastanede yatan SARS-CoV-2 hastalarında kötü klinik sonuçları tahmin etmek için etkili bir araçtır. Kullanımını doğrulamak için daha fazla çalışmaya ihtiyaç vardır., Aim: Multilobar infiltration, lymphocytopenia, bacterial co-infection, smoking history, hypertension, and age>65 (MuLBSTA) score is a clinical prediction rule used to classify patients with viral pneumonia by expected mortality. We compared the predictive performance of MuLBSTA with PSI, CURB-65, and qSOFA for poor clinical outcomes in hospitalized severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) patients.Methods: A retrospective study was conducted on patients with SARS-CoV-2 who were hospitalized in a tertiary medical center between March 11, 2020, and May 31, 2020. 271 out of 900 patients who tested positive for SARS-CoV-2 were included in the study. The MuLBSTA, PSI, CURB-65, and qSOFA scores were used to assess thirty-day mortality, need for intensive care unit (ICU), mechanical ventilation (MV) requirement, and development of acute respiratory distress syndrome (ARDS) in all patients. Prognostic factors were also analyzed for thirty-day mortality.Results: Among all 271 hospitalized patients, 150 males (55.3%) were included. The mean age was 54.2±15.4 years. The 30-day mortality rate was 10.7%. Of the patients included in the study; 39 patients (14.3%) were admitted to the intensive care unit, 32 patients (11.8%) received mechanical ventilator support, and 23 patients (8.4%) were diagnosed with ARDS. In predicting mortality, the area under the curve (AUC) of the MuLBSTA, PSI, CURB-65 and qSOFA scores were 0.877 (95% CI 0,832 0,914), 0.853 (95% CI 0,806-0,893), 0.769 (95% CI 0,714-0,817) and 0.769 (95% CI 0,715-0,818), respectively. The MuLBSTA score showed a higher AUC value compared to other prediction scores. The MuLBSTA and PSI scores performed better than CURB-65 and qSOFA scores in determining patients’ need for ICU, MV requirement, and ARDS development.Conclusion: The MuLBSTA score is an efficient tool to predict poor clinical outcomes in hospitalized patients with SARS-CoV-2. Further studies are warranted to validate its use.

Published
2022

3. AIDS İlişkili Pneumocystis Jirovecii Pnömonisi: Bir Vaka Serisi

Author

Okay, Gülay, Karakuş, Hatice Dilara, Durdu, Bülent, Aslan, Turan, Meriç Koç, Meliha, Akkoyunlu, Yasemin, OKAY, GÜLAY, DURDU, BÜLENT, AKKOYUNLU, YASEMİN, MERİÇ KOÇ, MELİHA, KARAKUŞ, HATİCE DİLARA, and ASLAN, TURAN

Subjects
Bir Vaka Serisi-, HIV / AIDS Kongresi 2021, Antalya, Türkiye, 18 - 21 Kasım 2021, ss.90-91 [Karakuş H. D. , Meriç Koç M., Akkoyunlu Y., Durdu B., Okay G., Aslan T., -AIDS İlişkili Pneumocystis Jirovecii Pnömonisi]
Published
2021

4. HIV/AIDS ilişkili Kaposi Sarkomu Tanısı Alan Olgularımızın Klinik Özellikleri

Author

Meriç Koç, Meliha, Ekşi, Çağla, Okay, Gülay, Akkoyunlu, Yasemin, Aslan, Turan, Durdu, Bülent, ASLAN, TURAN, AKKOYUNLU, YASEMİN, DURDU, BÜLENT, OKAY, GÜLAY, EKŞİ, ÇAĞLA, and MERİÇ KOÇ, MELİHA

Subjects
Ekşi Ç., Okay G., Durdu B., Akkoyunlu Y., Aslan T., Meriç Koç M., -HIV/AIDS ilişkili Kaposi Sarkomu Tanısı Alan Olgularımızın Klinik Özellikleri-, HIV / AIDS Kongresi 2021, Antalya, Türkiye, 18 - 21 Kasım 2021, ss.103-104
Published
2021

5. Efficacy of Tocilizumab in Patients with a Moderate and Severe COVID-19: A Retrospective Single Center Cohort Study

Author

Meriç Koç, Meliha, Karakuş, Hatice Dilara, Durdu, Bülent, Aslan, Turan, Okay, Gülay, Akkoyunlu, Yasemin, Sümbül, Bilge, MERİÇ KOÇ, MELİHA, DURDU, BÜLENT, SÜMBÜL, BİLGE, ASLAN, TURAN, OKAY, GÜLAY, KARAKUŞ, HATİCE DİLARA, and AKKOYUNLU, YASEMİN

Subjects
A Retrospective Single Center Cohort Study-, Mediterranean journal of infection microbes and antimicrobials , cilt.10, sa.1, ss.1-7, 2021 [Karakuş H. D. , Okay G., Akkoyunlu Y., Sümbül B., Durdu B., Meriç Koç M., Aslan T., -Efficacy of Tocilizumab in Patients with a Moderate and Severe COVID-19]
Published
2021

6. The investigation of E138 codon changes and cluster analysis in naive HIV-infected patients, Istanbul Turkey

Author

Mete, B., Midilli, K., Yucebag, E., Yildiz, D., TABAK, Ömer Fehmi, MERİÇ KOÇ, MELİHA, Oncul, A., Gunduz, A., Aydin, O. Altuntas, Karaosmanoglu, H. Kumbasar, Zerdali, E., Kuskucu, M. A., Tok, Y. Tuyji, Erdem, H., and MERİÇ KOÇ, MELİHA

Subjects
Kuskucu M. A. , Tok Y. T. , Erdem H., Yucebag E., Mete B., Yildiz D., Zerdali E., Karaosmanoglu H. K. , Aydin O. A. , Gunduz A., et al., -The investigation of E138 codon changes and cluster analysis in naive HIV-infected patients, Istanbul Turkey-, HIV MEDICINE, cilt.22, ss.63-64, 2021
Published
2021

7. Subtype distribution and drug resistance mutations in naive HIV-infected people, Istanbul, Turkey

Author

Mete, B., Midilli, K., Yucebag, E., Yildiz, D., TABAK, Ömer Fehmi, MERİÇ KOÇ, MELİHA, Gunduz, A., Aydin, O. Altuntas, Karaosmanoglu, H. Kumbasar, Zerdali, E., Oncul, A., Kuskucu, M. A., Tok, Y. Tuyji, Erdem, H., and MERİÇ KOÇ, MELİHA

Subjects
Kuskucu M. A. , Tok Y. T. , Erdem H., Yucebag E., Mete B., Yildiz D., Oncul A., Zerdali E., Karaosmanoglu H. K. , Aydin O. A. , et al., -Subtype distribution and drug resistance mutations in naive HIV-infected people, Istanbul, Turkey-, HIV MEDICINE, cilt.22, ss.59-61, 2021
Published
2021

8. Non-inferiority of Generic Tenofovir Disoproxil Fumarate/ Emtricitabine, Hivent® to Brand Name, Truvada® in HIV-Infected Patients

Author

İnan, Dilara, Öztoprak, Nefise, Kurtaran, Behice, Altuntaş Aydın, Özlem, Gümüşer, Fatma, Tabak, Fehmi, Bilge, Bilgenur, Meriç Koç, Meliha, Gencer, Serap, Öngüru, Pınar, Karabay, Oğuz, Köse, Şükran, Mete, Bilgül, and Gündüz, Alper

Abstract

Objective: Antiretroviral agents provided a significant improvement in HIV-related mortality. Generic drugs decrease the cost and provide easieraccess to treatment. However, there are concerns about efficacy and safety. We assessed non-inferiority of generic tenofovir disoproxil fumarate/emtricitabine, Hivent® to brand name drug, Truvada® in a retrospective cohort.Methods: Nine centers from Turkey were enrolled and the study included 457 patients followed up between May 2015 and April 2017 with Truvada®(n = 227) and Hivent® (n = 230) in combination with other antiretrovirals. Baseline characteristics were comparable in both groups. Demographiccharacteristics and laboratory values at baseline and during treatment were recorded. The primary endpoint was virologic response after 12 monthsof therapy, as determined by Snapshot algorithm from Food and Drug Administration (FDA). The sample size calculation was based on the primaryendpoint. Non-inferiority margin was taken as 10%.Results: After 12 months of therapy, both drugs provided a comparable decline in HIV-RNA: The values at baseline, 1st, 3rd, 6th, 9th, and 12th monthby Truvada® were 6.32, 3.62, 2.52, 3.53, 3.01, and 1.71 log10 copies/mL, respectively and values by Hivent® were 5.93, 3.89, 2.18, 1.72, 3.63, and1.54 log10 copies/mL, respectively (P = .33). Both drugs provided a comparable significant increase in CD4+ cell count: values By Truvada® were338, 412, 472, 497, 511, and 580 cells/mL, respectively and values by Hivent® were 337, 503, 531, 553, 644, and 660 cells/mL (P = .13). The rateand severity of side effects were similar and the changes in biochemical parameters were not different.Conclusion: This retrospective cohort study showed that Hiv

Published
2022

9. Anti-CD20 İçerikli İmmünsüpresif Tedavi Protokolleri ve HBV Reaktivasyonu

Author

Meriç Koç, Meliha, Andiç, Nurgül, Bolukçu, Sibel, and MERİÇ KOÇ, MELİHA

Subjects
Bolukçu S., Andiç N., Meriç Koç M., -Anti-CD20 İçerikli İmmünsüpresif Tedavi Protokolleri ve HBV Reaktivasyonu-, XXI. Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kongresi, İstanbul, Türkiye, 26 - 30 Mayıs 2021, ss.351-352
Published
2021

10. İmmünsupresif Hastada İntramuskuler Apselerle Seyreden Salmonella Enterica Bakteriyemisi

Author

Aslan, Turan, Özmen, Mehmet Emin, Durdu, Bülent, Meriç Koç, Meliha, Okay, Gülay, Yüce, Nurgül, ASLAN, TURAN, DURDU, BÜLENT, YÜCE, NURGÜL, OKAY, GÜLAY, ÖZMEN, MEHMET EMİN, and MERİÇ KOÇ, MELİHA

Subjects
Özmen M. E. , Okay G., Yüce N., Durdu B., Aslan T., Meriç Koç M., -İmmünsupresif Hastada İntramuskuler Apselerle Seyreden Salmonella Enterica Bakteriyemisi-, 9. Türkiye EKMUD Bilimsel Platformu, Antalya, Türkiye, 20 - 23 Mayıs 2021, ss.101
Published
2021

11. Actinomyces Odontolyticus Enfeksiyonlarına 2 Olgu ile Bakış

Author

Sümbül, Bilge, Karakuş, Hatice Dilara, Ekşi, Çağla, Meriç Koç, Meliha, Akkoyunlu, Yasemin, Uslu, Ayşe Betül, SÜMBÜL, BİLGE, EKŞİ, ÇAĞLA, USLU, AYŞE BETÜL, AKKOYUNLU, YASEMİN, KARAKUŞ, HATİCE DİLARA, and MERİÇ KOÇ, MELİHA

Subjects
Karakuş H. D. , Akkoyunlu Y., Uslu A. B. , Ekşi Ç., Sümbül B., Meriç Koç M., -Actinomyces Odontolyticus Enfeksiyonlarına 2 Olgu ile Bakış -, 9. Türkiye EKMUD Bilimsel Platformu, Antalya, Türkiye, 20 - 23 Mayıs 2021, ss.1
Published
2021

12. Real life efficacy, renal and lipid profile data of tenofovir alafenamide in switched chronic hepatitis B patients

Author

Tabak, Fehmi, Guner, Rahmet, Yoruk, Gulsen, Karabay, Oguz, Yamazhan, Tansu, Baykam, Nurcan, Yildirim, Mustafa, Ince, Nevin, YILDIZ, İLKNUR ESEN, Dokmetas, Ilyas, MERİÇ KOÇ, MELİHA, Koksal, Iftihar, Ceken, Sabahat, Inan, Dilara, Bozkurt, I., Turker, Kamuran, Celebi, Guven, Batirel, Ayse, Unlu, Gulten, Gunal, Ozgur, Gorenek, Levent, Sirmatel, Fatma, Sener, Alper, Parlak, Emine, and Kose, ŞÜKRAN

Subjects
Hepatology
Published
2022

13. COVID-19-da Hastaneye Başvuru Sırasında Nörolojik Semptomlar: Tek Merkez Deneyemi- Ön Veriler

Author

Uslu, Ferda, Okay, Gülay, Meriç Koç, Meliha, Gürsoy, Azize Esra, and MERİÇ KOÇ, MELİHA

Subjects
Tek Merkez Deneyemi- Ön Veriler-, COVID-19 Pandemisinde Araştırma-Yayın ve Eğitim Süreçlerine Bakış Kongre, İzmir, Türkiye, 15 - 16 Ocak 2021, ss.11 [Uslu F., Okay G., Meriç Koç M., Gürsoy A. E. , -COVID-19-da Hastaneye Başvuru Sırasında Nörolojik Semptomlar]
Published
2021

14. COVID-19-DA HASTANEYE BAŞVURU SIRASINDA NÖROLOJİK SEMPTOMLAR: TEK MERKEZ DENEYEMİ- ÖN VERİLER

Author

USLU, FERDA, GÜRSOY, AZİZE ESRA, MERİÇ KOÇ, MELİHA, OKAY, GÜLAY, USLU, Ferda, MERİÇ KOÇ, MELİHA, and GÜRSOY, Azize Esra

Subjects
TEK MERKEZ DENEYEMİ- ÖN VERİLER-, COVID-19 Pandemisinde Araştırma-Yayın ve Eğitim Süreçlerine Bakış Kongresi, Türkiye, 15 - 16 Ocak 2021 [USLU F., OKAY G., MERİÇ KOÇ M., GÜRSOY A. E. , -COVID-19-DA HASTANEYE BAŞVURU SIRASINDA NÖROLOJİK SEMPTOMLAR]
Published
2021

15. COVID-19 Pandemisi Döneminde HIV ile İnfekte Bireylerin Hastalık Anksiyetelerinin İrdelenmesi

Author

Meriç Koç, Meliha, Bolukçu, Sibel, Andiç, Nurgül, and YÜCE, NURGÜL

Subjects
Bolukçu S., Andiç N., Meriç Koç M., -COVID-19 Pandemisi Döneminde HIV ile İnfekte Bireylerin Hastalık Anksiyetelerinin İrdelenmesi-, HIV/AIDS Kongresi 2021, Antalya, Türkiye, 18 - 21 Kasım 2021, ss.38
Abstract

Amaç: COVİD-19 pandemisi döneminde bazı sağlık anksiyetesi çalışmaları literatürde mevcuttur.Bununla birlikte mortalite ve morbiditesi yüksek, aynı zamanda toplumda damgalanma riski olan HİVpozitif kişilerin pandemi dönemine ait sağlık anksiyesini değerlendiren sınırlı sayıda çalışma mevcuttur.Literatürde, COVİD-19 pandemi döneminde genel ve sağlık anksiyetesini değerlendiren anket çalışmalarıbulunmaktadır. Sağlık anksiyetesini değerlendiren -Sağlık anksiyete envanteri- (HAI)’de 18 soru mevcut,sorular 0-3 arası puanlandırmıştır. Bu ölçeklendirme envanteri Türkçe’ye valide edilmiştir. Puan arttıkçasağlık anksiyetesi yükselmektedir. Literatürde HİV ve COVİD-19 pandemisi için özel bir ölçeklendirmebulunmadığı için bu ölçeklendirmeden faydalanılarak 14 soruluk mini bir anket oluşturuldu. Bilindiğiüzere HİV ile infekte bireylerin mortalite ve morbiditesi yüksektir. Bu nedenle bu hasta grubunda normalşartlarda anksiyetesi yüksek olan bireylerdir. Çalışmamızda pandemi döneminde toplum genelinde artansağlık anksiyetesinin özellikle HİV ile infekte olan kişilerdeki durumunu irdelemeyi amaçladık.Yöntem: Çalışmaya kliniğimizde takip ettiğimiz HİV ile infekte bireyler dahil edildi. Gönüllü olur formusözel olarak kendilerine iletilecek ve sözlü olarak onamları alındı ve telefon uygulaması üzerinden anketsoruları aktarıldı. Ankete katılan kişilerin demografik verileri, pandemi döneminde iş durumları ve HİV tanıve takibi ile ilgili süreci değerlendirilen sorular yanı sıra 14 soru anksiyetenin varlığını değerlendirmek içinsoruldu ve 0-3 arası puanlandı. Anket sonunda yüksek puan alan kişilere psikiyatrik muayene önerisindebulunuldu. Bu kişilerin sonrasında takibi yapıldı ve ilaç kullanımları da ayrıca sorgulandı.Bulgular: Çalışmaya 196 kişi dahil edildi. Bunların %86,7’si erkek (n=170), yaşlarının ortalaması 41,16±10,96ve tanı alma yıllarının ortancası 3,39 (1,5-5,6) idi. -Sağlığımla ilgili her zaman endişelenirim-, -Dışgörünüşüme ilgimi kaybettim-, -Eskiden zevk aldığım şeylerden eskisi kadar zevk alamıyorum-, -Gerginhissediyorum-, -Ailem ve dostlarım hastalık hastası olduğumu söyler- sorularına kadınlar anlamlı şekildeyüksek puan verdi (sırasıyla p=0,03, p=0,001, p=0,02, p=0,01 ve p=0,004) idi. Anti-psikiyatrik ilaç ihtiyacıve psikolog desteğine ihtiyacı olduğunu ifade edenler her iki cinsiyette benzerdi (p=0,05 ve p=0,26).Anti-psikiyatrik ilaç ihtiyacı olanların ve olmayanların yaş ortalamaları benzerdi (p=0,19)Sonuç: Çalışmamız salgın döneminde HİV ile yaşayan bireylerin COVİD-19 pandemisi döneminde özelliklekadın cinsiyette olanların ruh sağlığı açısından daha fazla etkilendiğini göstermektedir. HİV ile yaşayanbireylerin normal koşullarda dahi onları zorlayan şartların yanı sıra pandeminin getirdiği yeni duygusal vemaddi yüklerle ruh sağlıklarının daha fazla etkileneceği dikkate alınarak bu popülasyon için daha ayrıntılıtestlerin geliştirilmesinin yararlı olacağı kanısındayız.Anahtar Kelimeler: HİV, COVİD-19, anket

Published
2021

17. EACS Guidelines Version 9.1 Türkçe

Author

Meriç Koç, Meliha and MERİÇ KOÇ, MELİHA

Subjects
Meriç Koç M., Fırsatçı enfeksiyonlar, -EACS Guidelines Version 9.1 Türkçe-, Fehmi Tabak, Editör, İstanbul Medikal Yayıncılık, İstanbul, ss.88-99, 2019
Published
2019

18. Hastanemizde Son 10 Yılda Görülen Kist Hidatik Vakalarının Değerlendirilmesi

Author

Bolukçu, Sibel, Durdu, Bülent, Okay, Gülay, Akkoyunlu, Yasemin, Yüce, Nurgül, Meriç Koç, Meliha, and AKKOYUNLU, YASEMİN

Subjects
Yüce N., Bolukçu S., Akkoyunlu Y., Okay G., Durdu B., Meriç Koç M., -Hastanemizde Son 10 Yılda Görülen Kist Hidatik Vakalarının Değerlendirilmesi-, XXI. Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kongresi, İstanbul, Türkiye, 26 - 30 Mayıs 2021, ss.587-588
Published
2021

21. İmmünsüpresif Tedavi Alan Hastalarda Hepatit B Profilaksisi

Author

Yüce, Nurgül, Meriç Koç, Meliha, Bolukçu, Sibel, Uslu Ersöz, Ayşe Betül, and MERİÇ KOÇ, MELİHA

Subjects
Yüce N., Uslu Ersöz A. B. , Bolukçu S., Meriç Koç M., -İmmünsüpresif Tedavi Alan Hastalarda Hepatit B Profilaksisi-, 7. Türkiye EKMUD Bilimsel Platformu, Antalya, Türkiye, 3 - 07 Nisan 2019, ss.156-157
Published
2019

22. İmmunsupresif Tedavi Alan Hastalarda Hepatit B Profilaksisi

Author

Meriç Koç, Meliha and MERİÇ KOÇ, MELİHA

Subjects
Meriç Koç M., -İmmunsupresif Tedavi alan hastalarda Hepatit B profilaksisi-, 7. TÜRKiYE EKMUD BİLİMSEL PLATFORMU , Antalya, Türkiye, 3 - 07 Nisan 2019, cilt.8, ss.159-160, Meriç Koç M., -İmmunsupresif Tedavi Alan Hastalarda Hepatit B Profilaksisi-, 7. Türkiye EKMUD Bilimsel Platformu, Antalya, Türkiye, 3 - 07 Nisan 2019, cilt.8, ss.96-97
Published
2019

23. Türkiye’de Hastanelerde El Hijyeni Uyum Oranları AsklepionÇalışmasının Sonuçları

Author

UYAN ÖNAL, AYŞE, AKSOY, FİRDEVS, AZAK KARALİ, EMEL, MERİÇ KOÇ, MELİHA, alkan çeviker, sevil, ATAMAN HATİPOĞLU, ÇİĞDEM, GÖZÜKÜÇÜK, RAMAZAN, sehmen, emine, uğurlu, kenan, güneş, şenol, durmuş, gül, ELMASLAR MERT, HABİBE TÜLİN, ALAY, HANDAN, koç, filiz, çağlayan, derya, ulusoy, behice, dikiş, demet, PULLUKÇU, HÜSNÜ, ARDA, BİLGİN, ULUSOY, SERCAN, SİPAHİ, OĞUZ REŞAT, and MERİÇ KOÇ, MELİHA

Subjects
UYAN ÖNAL A., AKSOY F., AZAK KARALİ E., MERİÇ KOÇ M., alkan çeviker s., ATAMAN HATİPOĞLU Ç., GÖZÜKÜÇÜK R., sehmen e., uğurlu k., güneş ş., et al., -Türkiye’de Hastanelerde El Hijyeni Uyum Oranları AsklepionÇalışmasının Sonuçları-, 7. TÜRKİYE EKMUD ULUSLARARASI KONGRESİ, 3 - 08 Mayıs 2018
Published
2018

24. Bezmialem Vakıf Üniversitesi Tıp Fakültesi Araştırma Eğitiminde Uygulanan Bilimsellik Yatay Stajı ve Değerlendirme Sonuçları*

Author

ÖZÇELİK, Semra, ARICI, Dilek Sema, MERİÇ KOÇ, Meliha, and KAZANCIOĞLU, Rümeyza

Subjects
Health Care Sciences and Services, ComputingMilieux_COMPUTERSANDEDUCATION, Araştırma eğitimi,Bilimsellik, Medical education,Research education,Scholarly, Sağlık Bilimleri ve Hizmetleri
Abstract

ÖZETTıp Eğitiminde; bilimsel araştırmatasarlama sorumluluğu üstlenebilen hekimler yetiştirmek, tıp fakültelerinin mezun yeterlilikleriarasında yer almaktadır. Her öğrencinin sorumluluğunu üstlenerek, bilimsel biraraştırma yapmasını sağlayacak “araştırma eğitimi programı” fakültemizde klinik dönemde bilimsellikkomitesi/stajı adı verilen bir yatay stajla gerçekleşmektedir. Bu çalışmanınamacı, uygulamanın nasıl yapıldığı ve değerlendirildiğini açıklamak ve edinilendeneyimleri paylaşmaktır. Bu stajda,amacı ve içeriği belirlenmiş altı modülde, araştırma eğitimine yönelik konferanslarve öğrencilerin mentörleri ile birlikte hazırlamış oldukları araştırmalarınaşamaları yer almaktadır. Öğrenciler, kendilerine bir mentör öğretim üyesiseçmekte ve bu öğretim üyesiyle standart bir sözleşme imzalamaktadırlar. İlkmodülden itibaren bir araştırma sorusu oluşturmaları, bilimsel literatürtaramaları yapmaları, etik kurul başvurusu, proje hazırlamaları ve projemalzemelerini sağlamaları gerekmektedir. İstatistiksel destek alma, araştırmayısürdürme ve bitirme sorumlulukları da bulunmaktadır. Modüllerde öğretim üyeleritarafından konferanslar verilmekte ve küçük gruplara ayrılan öğrenciler,projelerinin aşamalarını komisyonda yer alan öğretim üyesi ve gruparkadaşlarına sunmaktadır. Her modülün gerektirdiği aşama belirlenmiş ve birkılavuzda yayınlanmıştır. Üç yarıyıl süren bu yatay stajın sonunda öğrencileraraştırmalarını Tıp Bayramında düzenlenen “Araştırma Günü” etkinliklerindesözlü veya poster bildirileri şeklinde sunmaktadırlar. Fakültemiz öğretim üyelerindenoluşan Bilimsellik Stajı Komisyonu, uygulamayı düzenlemekte, modüllerde görevalmakta ve tüm taraflardan alınan geribildirimleri değerlendirerek üstbirimlere rapor etmektedir. Uygulamayı eşgüdümlü olarak yürüttüğümüz JohnsHopkins Üniversitesi öğretim üyeleri de her modüle katkı sunmaktadır. Ölçme vedeğerlendirme, modüllerde gösterdikleri ilerlemelere göre, yapılandırılmış birpuanlama sistemiyle gerçekleştirilir. Sonuç: BilimsellikKomitesi/Stajı, Bezmialem Vakıf Üniversitesi Tıp Fakültesi program çıktılarındada yer alan «Bilimsellik» maddesi kapsamında, öğrencilerimize bilimselokur-yazarlığı öğretmek amaçlı oluşturulmuştur. BVÜ öğrencilerinin bu aşamalarıbirebir yaşayarak ve yaparak öğrenmelerinin eğitimlerine önemli katkısınınolacağı ve benzer uygulamaların yaygınlaşmasının ülkemizde araştırmacı-hekimsayısında artış sağlayacağı kanısındayız., Aim: Research Training Program, which will enable to carry out scientific research by taking responsibility of each student, is carried out in our faculty with an internship called “Scholarly Concentrations Program” in clinical period. The aim of this study is to explain how the practice is done and to evaluate and to share the experiences gained.Material and Methods: In this internship, there are six modules whose purpose and content are determined. In these modules, there are conferences for research education and stages of research that students have prepared together with their advisors. Students choose a adviser among faculty member and sign a standard contract with them. A commission called the Scientific Internship Commission has been established to plan, conduct and control this program. From the first module, students should create a research question with their advisors, make scientific literature reviews, get approval from the ethics committee, and prepare a project if necessary and apply to Scientific Research Projects Unit (BAP). They also have the responsibility to receive statistical support and to continue and complete the research. In the modules, lectures are given by faculty members on research principles. Students are divided into small groups and present the stages of their projects to members of the Scientific Internship Commission and their group friends. Stages of each module have been created and published in a manual. At the end of three semesters of internship, students present their research in the form of oral or poster presentations in the “Research Day” activities organized at Medical Day. The Scientific Internship Commission organizes the program, takes part in the modules and evaluates the feedback received from all parties and reports to the upper units. The members of the Johns Hopkins University, which with whom we coordinate with the program, also contribute to each module. Measurement and evaluation is carried out with a structured scoring system for each module.Results: Scholarly Concentration in 2015-2016 academic year has begun with Term IV and on 14 March 2017 a total of 93 research has been completed and presented as an oral or poster presentation. On the 14th of March 2018, 100 students, who completed the next semester successfully, completed their studies. At present, 130 students in Term IV and 126 students in Term V are continuing their studies to carry out research projects. The research abstracts of 193 students have been published in the supplementary edition of Bezmialem Science, and it is planned to publish the completed projects each year.Conclusion: Scholarly Concentration is designed to teach students scientific literacy. We think that the learning of BVU students by making and living these stages will have a significant contribution to their education. We believe that the spread of similar practices will increase the number of researcher physician in our country.

Published
2019

25. Hepatosteatozun entekavir ve tenofovir tedavilerinde virolojik yanıta etkisi

Author

Korkmaz, Pınar, Demirtürk, Neşe, Batırel, Ayşe, Tülek, Necla, Özgüler, Müge, Harman, Rezan, Çınar, Güle, Toka, Onur, Yörük, Gülşen, Ataman Hatipoğlu, Çiğdem, Sarıgül, Figen, Sırmatel, Fatma, İmre, Ayfer, Mıstanoğlu Özatağ, Duru, Karakeçili, Faruk, Ural, Onur, Sümer, Şua, Aktuğ Demir, Nazlım, Kadanalı, Ayten, Çomoğlu, Şenol, Üçer, Şengül, Saltoğlu, Neşe, Günal, Özgür, Özkaya, Hacer Deniz, Yenilmez, Ercan, Çetinkaya, Rıza Aytaç, Yüksel, Esma, Hakyemez, İsmail Necati, Meriç Koç, Meliha, Tuncer Ertem, Günay, Beştepe Dursun, Zehra, Çelik, İlhami, Yılmaz, Emel, Evik, Güliz, Kaya, Ali, Süer, Kaya, Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ural, Onur, Sümer, Şua, Demir, Nazlım Aktuğ, and Demirtürk, Neşe

Subjects
entekavir, Fatty liver, Yağlı karaciğer, tenofovir, entecavir
Abstract

WOS: 000511173500009, Amaç: Hem kronik hepatit B (KHB) hem de hepatosteatoz karaciğerde nekroinflamasyona yol açabilir. Bu nedenle hepatosteatozun varlığı antiviral tedavinin etkinliğini olumsuz yönde etkileyebilir. Bu çalışmada karaciğer yağlanmasının KHB’de entekavir (ETV) ve tenofovir (TDF) alan hastalarda virolojik yanıta etkisinin değerlendirilmesini amaçladık. Yöntemler: Çalışma retrospektif olarak planlandı. Yirmi dokuz farklı merkezde, Ocak 2012-Haziran 2017 tarihleri arasında İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji kliniklerinde KHB tanısıyla antiviral tedavi verilen tüm hastalar hastane dosyası kayıtları incelenerek tarandı. Bulgular: Çalışmaya toplam 1069 hasta dahil edildi. Çalışmaya dahil edilen hastaların 650’si TDF, 419’u ETV tedavisi almaktaydı. TDF tedavisi alanlarda steatoz olan hastalarda 48. haftada elde edilen virolojik yanıt oranı daha yüksekti (p=0.029). ETV tedavisi alan hastalarda steatoz olmayan hastalarda 24. ve 48. haftadaki virolojik yanıt oranı daha yüksekti (p=0.001). Hepatosteatozu olan hastalarda TDF ve ETV tedavilerinin etkinliği karşılaştırıldı ve virolojik yanıt yönünden 48. hafta sonunda virolojik yanıtın TDF grubunda yüksek olduğu tespit edildi. Sonuçlar: Steatoz, her iki nükleoz(t)id tedavisinin kısa dönemdeki sonuçları bakımından virolojik yanıt üzerinde etkili olsa bile uzun dönemdeki sonuçlar bakımından virolojik yanıtı etkilememektedir., Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48'h week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results.

Published
2019

26. Tetanus in adults: results of the multicenter ID-IRI study

Author

MERİÇ KOÇ, MELİHA and MERİÇ KOÇ, MELİHA

Subjects
results of the multicenter ID-IRI study.-, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, ss.1455-1462, 2017 [MERİÇ KOÇ M., -Tetanus in adults]
Published
2017

27. Are there enough nurses in Turkey? Results of the multicenter Karia study

Author

UYAN, AYŞE, durmuş, gül, sezak, nurbanu, pepe, fatmanur, ÖZTÜRK KAYGUSUZ, TÜRKKAN, akyol, firdevs, EROL, SERPİL, MERİÇ KOÇ, MELİHA, öncül, ahsen, aktaş, sabahat, ÇAŞKURLU, HÜLYA, ÇELEBİ, GÜVEN, EVİK, GÜLİZ, özger, hasan, harman, rezzan, TAŞBAKAN, MELTEM, ARDA, BİLGİN, ULUSOY, SERCAN, SİPAHİ, OĞUZ REŞAT, and MERİÇ KOÇ, MELİHA

Subjects
UYAN A., durmuş g., sezak n., pepe f., ÖZTÜRK KAYGUSUZ T., akyol f., EROL S., MERİÇ KOÇ M., öncül a., aktaş s., et al., -Are there enough nurses in Turkey? Results of the multicenter Karia study-, 27.ECCMID The European Congress of Clinical Microbiology and Infectious Diseases, 22 - 25 Nisan 2017
Published
2017

28. Diyabetik Hastaların Ayak Bakımına Verdikleri Özenin Değerlendirilmesi

Author

YILMAZ KARADAĞ, FATMA, SALTOĞLU, NEŞE, Ak, Öznur, ÇINAR, GÜLE, ŞENBAYRAK, SENİHA, EROL, SERPİL, MISTANOĞLU ÖZATAĞ, DURU, KADANALI, AYTEN, KÜÇÜKARDALI, YAŞAR, ÇOMOĞLU, ŞENOL, YÖRÜK, GÜLŞEN, AKKOYUNLU, YASEMİN, MERİÇ KOÇ, MELİHA, ALTUNÇEKİÇ YILDIRIM, ARZU, and AKKOYUNLU, YASEMİN

Subjects
YILMAZ KARADAĞ F., SALTOĞLU N., Ak Ö., ÇINAR G., ŞENBAYRAK S., EROL S., MISTANOĞLU ÖZATAĞ D., KADANALI A., KÜÇÜKARDALI Y., ÇOMOĞLU Ş., et al., -Diyabetik Hastaların Ayak Bakımına Verdikleri Özenin Değerlendirilmesi-, V. Ulusal Diyabetik Ayak İnfeksiyonları Simpozyumu ( Uluslararası Katılımlı), 3 - 06 Mayıs 2018
Published
2018

29. Effectiveness of daptomycin therapy in neutropenic patients with haematological malignancies Hematolojik maligniteli nötropenik hastalarda daptomisin tedavisinin etkinliği

Author

Meriç-Koç, MELİHA, Aynıoğlu, Aynur, TARKUN, PINAR, and MERİÇ KOÇ, MELİHA

Subjects
Meriç-Koç M., Aynıoğlu A., TARKUN P., -Effectiveness of daptomycin therapy in neutropenic patients with haematological malignancies Hematolojik maligniteli nötropenik hastalarda daptomisin tedavisinin etkinliği-, Klimik Dergisi, cilt.28, ss.72-75, 2015
Published
2015

30. Efficacy and safety of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in HIV-positive patients: real-world data

Author

Fehmi Tabak, Esra Zerdali, Dilek Yildiz, Hayat Kumbasar Karaosmanoglu, Alper Gunduz, Ilyas Dokmetas, Meliha Meriç Koç, Sibel Bolukcu, Inci Yilmaz Nakir, Bilgul Mete, Ozlem Altuntaş, BOLUKÇU, SİBEL, and MERİÇ KOÇ, MELİHA

Subjects
Adult, Male, Human immunodeficiency virus (HIV), HIV Infections, Dermatology, Quinolones, medicine.disease_cause, Emtricitabine, Tenofovir alafenamide, Sexual and Gender Minorities, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Homosexuality, Male, Tenofovir, 0303 health sciences, Alanine, Elvitegravir/cobicistat/emtricitabine/tenofovir, 030306 microbiology, business.industry, Elvitegravir, Cobicistat, Public Health, Environmental and Occupational Health, Virology, Regimen, Infectious Diseases, business, Real world data, medicine.drug
Abstract

Objectives: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) is a recommended and widely used regimen for HIV infection. In this study, we aimed to determine the efficacy and safety of E/C/F/TAF in people living with HIV (PLWH), who are either treatment-naïve or switched from any tenofovir disoproxil fumarate-containing regimen. For switched patients, we aimed to determine the impact of switching from tenofovir disoproxil fumarate (TDF) to TAF on lipid profile and kidney functions. Methods: ACTHIV-IST Study Group produced a database, and five dedicated HIV centres in Istanbul entered data of PLWH who switched from any TDF-containing regimen to E/C/F/TAF and treatment-naïve patients who were initiated with the E/C/F/TAF regimen between January 2017 and December 2019. Clinical findings, viral parameters, lipid studies, renal function tests, adverse events and adherence to the treatment were recorded in this prospective observational study. Results: The study included a total of 614 switched and treatment-naïve patients. Of 430 treatment-experienced patients, 89% (382) were men, and the mean age was 42 ± 12 years. Among them, 47% (181/382) self-identified as men who have sex with men (MSM). The median duration of HIV diagnosis was 54 ± 29 months. The median duration of E/C/F/TAF use was 20 ± 36 months and that of previous treatment was 23 ± 18 months. HIV-RNA was undetectable at baseline and month 12 in 84.1% (360/428) and 86.1% (328/381) of patients, respectively ( p > 0.05). Mean CD4 counts were 708 ± 287 cells/µL and 802 ± 305 cells/µL at baseline and month 12, respectively ( p < 0.001). Serum creatinine levels remained stable during the treatment period. Mean total cholesterol levels at baseline and month 12 were 172 and 211 mg/dL ( p < 0.01), LDL-cholesterol 104 and 138 mg/dL ( p < 0.01), HDL-cholesterol 39 and 49 mg/dL ( p < 0.01) and triglycerides 134 and 174 mg/dL ( p < 0.01), respectively. The treatment was generally well tolerated. Eight patients discontinued the therapy (drug interaction: 3; lost to follow-up: 1; pregnancy: 1; pulmonary tuberculosis: 1; side effect: 1; patient’s decision: 1). Of 184 treatment-naïve patients, 88% (162) were men, and the mean age was 36.5± 12 years. Among them, 50% (81/162) self-identified as MSM. The mean duration of HIV infection was 21.6 ± 17.1 months. The mean duration of E/C/F/TAF use was 16 ± 4 months. HIV-RNA was undetectable at baseline and month 12 in 1% and 89.1% of patients, respectively. Mean CD4 counts at baseline and month 12 were 469 ± 223 cells/µL and 740 ± 298 cells/µL, respectively. During the treatment period, creatinine levels remained stable. Total cholesterol, LDL-cholesterol, triglyceride and also HDL-cholesterol levels increased. Mean total cholesterol levels at baseline and month 12 were 167 and 211 mg/dL ( p < 0.01), LDL-cholesterol 108 and 143 mg/dL ( p < 0.01), HDL-cholesterol 41 and 47 mg/dL ( p < 0.01) and triglycerides 136 and 172 mg/dL, respectively ( p < 0.01). The treatment was generally well tolerated. Three patients discontinued the therapy (drug interaction: 1; non-responder: 1; patient’s decision: 1). Conclusion: Starting with or switching to E/C/F/TAF in PLWH effectively suppresses HIV infection, is associated with an increase in CD4 cell count and is well tolerated in a real-life setting. Renal functions remained stable during the treatment. E/C/F/TAF use was associated with an increase in LDL-cholesterol and triglyceride levels along with an increase in HDL-cholesterol levels.

Published
2021

31. Vaccine hesitancy and refusal among parents: An international ID-IRI survey

Author

Yakup Cag, Mohammad Emad Al Madadha, Handan Ankarali, Yasemin Cag, Kubra Demir Onder, Aysegul Seremet-Keskin, Filiz Kizilates, Rok Čivljak, Ghaydaa Shehata, Handan Alay, Sevil Alkan-Ceviker, Fatma Yilmaz-Karadag, Meliha Cagla-Sonmezer, Manar Ezzelarab Ramadan, Dumitru Irina Magdelena, Ljiljana Betica Radic, Jurica Arapovic, Fatma Kesmez-Can, Nagwa Mostafa El-Sayed, Oladapo Babatunde Campbell, Gulden Eser-Karlidag, Reham Khedr, Mehmet Emirhan Isik, Michael Mihailov Petrov, Roxana Cernat, Umran Erturk, Yesim Uygun-Kizmaz, Eva Huljev, Fatma Amer, Mehmet Resat Ceylan, Andrea Marino, Gulnur Kul, Tuba Damar-Cakirca, Yara Mohsen Khalaf, Arzu Cennet Isik, Olumuyiwa Elijah Ariyo, Ismail Necati Hakyemez, Rezaul Karim Ripon, Abdorrahim Afkhamzadeh, Emine Kubra Dindar-Demiray, Osasona Oluwadamilola Gideon, Maya Belitova, Mustafa Altindis, Rehab El-Sokkary, Recep Tekin, Mohammed Ahmed Garout, Joanna Zajkowska, Farhan Fazal, Muhammed Bekcibasi, Mirsada Hukic, Summiya Nizamuddin, Serkan Surme, Ricardo Fernandez, Amani El-Kholy, Nasim Akhtar, Saadia Ijaz, Andrea Cortegiani, Meliha Meric-Koc, Hakan Hasman, Agah Victor Maduka, Jehan Ali ElKholy, Sema Sari, Mumtaz Ali Khan, Yasemin Akin, Sukran Kose, Hakan Erdem, MERİÇ KOÇ, MELİHA, Cag, Yakup, Al Madadha, Mohammad Emad, Ankarali, Handan, Cag, Yasemin, Demir Onder, Kubra, Seremet-Keskin, Aysegul, Kizilates, Filiz, Čivljak, Rok, Shehata, Ghaydaa, Alay, Handan, Alkan-Ceviker, Sevil, Yilmaz-Karadag, Fatma, Cagla-Sonmezer, Meliha, Ezzelarab Ramadan, Manar, Magdelena, Dumitru Irina, Radic, Ljiljana Betica, Arapovic, Jurica, Kesmez-Can, Fatma, El-Sayed, Nagwa Mostafa, Campbell, Oladapo Babatunde, Eser-Karlidag, Gulden, Khedr, Reham, Isik, Mehmet Emirhan, Petrov, Michael Mihailov, Cernat, Roxana, Erturk, Umran, Uygun-Kizmaz, Yesim, Huljev, Eva, Amer, Fatma, Ceylan, Mehmet Resat, Marino, Andrea, Kul, Gulnur, Damar-Cakirca, Tuba, Khalaf, Yara Mohsen, Isik, Arzu Cennet, Ariyo, Olumuyiwa Elijah, Hakyemez, Ismail Necati, Ripon, Rezaul Karim, Afkhamzadeh, Abdorrahim, Dindar-Demiray, Emine Kubra, Gideon, Osasona Oluwadamilola, Belitova, Maya, Altindis, Mustafa, El-Sokkary, Rehab, Tekin, Recep, Garout, Mohammed Ahmed, Zajkowska, Joanna, Fazal, Farhan, Bekcibasi, Muhammed, Hukic, Mirsada, Nizamuddin, Summiya, Surme, Serkan, Fernandez, Ricardo, El-Kholy, Amani, Akhtar, Nasim, Ijaz, Saadia, Cortegiani, Andrea, Meric-Koc, Meliha, Hasman, Hakan, Maduka, Agah Victor, ElKholy, Jehan Ali, Sari, Sema, Khan, Mumtaz Ali, Akin, Yasemin, Kose, Sukran, and Erdem, Hakan

Subjects
Male, Parents, Health Knowledge, Attitudes, Practice, An international ID-IRI survey-, JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, cilt.16, sa.6, ss.1081-1088, 2022 [Cag Y., Al Madadha M. E. , ANKARALI H., ÇAĞ Y., Onder K. D. , Seremet-Keskin A., Kizilates F., Civljak R., Shehata G., ALAY H., et al., -Vaccine hesitancy and refusal among parents], Vaccination, General Medicine, Patient Acceptance of Health Care, Microbiology, Communicable Diseases, parent, Infectious Diseases, Cross-Sectional Studies, Virology, Surveys and Questionnaires, vaccine refusal, Humans, Parasitology, Female, Vaccination Hesitancy, Child, Vaccine hesitancy
Abstract

Introduction:Although vaccines are the safest and most effective means to prevent and control infectious diseases, the increasing rate of vaccine hesitancy and refusal (VHR) has become a worldwide concern. We aimed to find opinions of parents on vaccinating their children and contribute to available literature in order to support the fight against vaccine refusal by investigating the reasons for VHR on a global scale.Methodology:In this international cross-sectional multicenter study conducted by the Infectious Diseases International Research Initiative (ID-IRI), a questionnaire consisting of 20 questions was used to determine parents' attitudes towards vaccination of their children.Results:Four thousand and twenty-nine (4,029) parents were included in the study and 2,863 (78.1%) were females. The overall VHR rate of the parents was found to be 13.7%. Nineteen-point three percent (19.3%) of the parents did not fully comply with the vaccination programs. The VHR rate was higher in high-income (HI) countries. Our study has shown that parents with disabled children and immunocompromised children, with low education levels, and those who use social media networks as sources of information for childhood immunizations had higher VHR rates (p < 0.05 for all).Conclusions:Seemingly all factors leading to VHR are related to training of the community and the sources of training. Thus, it is necessary to develop strategies at a global level and provide reliable knowledge to combat VHR.Keywords:Vaccine hesitancy; parents; vaccine refusal.Copyright (c) 2022 Yakup Cag, Mohammad Emad al Madadha, Handan Ankarali, Yasemin Cag, Kubra Demir Onder, Aysegul Seremet-Keskin, Filiz Kizilates, Rok Civljak, Ghaydaa Shehata, Handan Alay, Sevil Alkan-Ceviker, Fatma Yilmaz-Karadag, Meliha Cagla-Sonmezer, Manar Ezzelarab Ramadan, Dumitru Irina Magdelena, Ljiljana Betica Radic, Jurica Arapovic, Fatma Kesmez-Can, Nagwa Mostafa El-Sayed, Oladapo Babatunde Campbell, Gulden Eser-Karlidag, Reham Khedr, Mehmet Emirhan Isik, Michael Mihailov Petrov, Roxana Cernat, Umran Erturk, Yesim Uygun-Kizmaz, Eva Huljev, Fatma Amer, Mehmet Resat Ceylan, Andrea Marino, Gulnur Kul, Tuba Damar-Cakirca, Yara Mohsen Khalaf, Arzu Cennet Isik, Olumuyiwa Elijah Ariyo, Ismail Necati Hakyemez, Rezaul Karim Ripon, Abdorrahim Afkhamzadeh, Emine Kubra Dindar-Demiray, Osasona Oluwadamilola Gideon, Maya Belitova, Mustafa Altindis, Rehab El-Sokkary, Recep Tekin, Mohammed Ahmed Garout, Joanna Zajkowska, Farhan Fazal, Muhammed Bekcibasi, Mirsada Hukic, Summiya Nizamuddin, Serkan Surme, Ricardo Fernandez, Amani El-Kholy, Nasim Akhtar, Saadia Ijaz, Andrea Cortegiani, Meliha Meric-Koc, Hakan Hasman, Agah Victor Maduka, Jehan Ali ElKholy, Sema Sari, Mumtaz Ali Khan, Yasemin Akin, Sukran Kose, Hakan Erdem.

Published
2022

32. Vector-borne and zoonotic infections and their relationships with regional and socioeconomic statuses: An ID-IRI survey in 24 countries of Europe, Africa and Asia

Author

Nesrin Ghanem-Zoubi, Meltem Taşbakan, Handan Ankarali, Md. Tanvir Rahman, Natalia Pshenichnaya, Taufiquer Rahman, Marta Vecchi, Alma Tokayeva, Maria Pishmisheva-Peleva, Pilli Hema Prakash Kumari, Roxana Carmen Cernat, Mumtaz Ali Khan, Fatma Nurhayat Saydam, Meliha Meric-Koc, Sholpan Kulzhanova, Edmond Puca, Roman Stebel, Kumar Angamuthu, Yasemin Cag, Fahad Almajid, Hakan Erdem, Aleksandra Barac, Nagwa Mostafa El-Sayed, Ravilya Yegemberdiyeva, Zarema Obradović, Gorana Dragovac, Nasim Akhtar, Manar Ezz El-Arab Ramadan, Fatemeh Moradi Mahmuodabad, Ayse Batirel, Antonio Cascio, Dumitru Irina Magdalena, Hakan Evren, Emanuele Nicastri, Marion Le Maréchal, Lenka Fasanekova, Mustafa Dogan, Serhat Uysal, Andrea Marino, Natalia Dirani, Nenad Pandak, Marija Dimzova, Alfonso J. Rodriguez-Morales, Jurica Arapović, Amangul Duisenova, Ilkay Bozkurt, Aamer Ikram, Stanislav Kotsev, Ejaz Ahmed Khan, Rosa Fontana Del Vecchio, Agah Victor Maduka, Ainur Sadykova, Safak Ozer-Balin, Ruxandra Moroti, Rok Čivljak, Amjad Mahboob, Samir Al-Moghazi, Yvon Ruch, MERİÇ KOÇ, MELİHA, Saydam F.N., Erdem H., Ankarali H., El-Arab Ramadan M.E., El-Sayed N.M., Civljak R., Pshenichnaya N., Moroti R.V., Mahmuodabad F.M., Maduka A.V., Mahboob A., Prakash Kumari P.H., Stebel R., Cernat R., Fasanekova L., Uysal S., Tasbakan M., Arapovic J., Magdalena D.I., Angamuthu K., Ghanem-Zoubi N., Meric-Koc M., Ruch Y., Marino A., Sadykova A., Batirel A., Khan E.A., Kulzhanova S., Al-Moghazi S., Yegemberdiyeva R., Nicastri E., Pandak N., Akhtar N., Ozer-Balin S., Cascio A., Dimzova M., Evren H., Puca E., Tokayeva A., Vecchi M., Bozkurt I., Dogan M., Dirani N., Duisenova A., Khan M.A., Kotsev S., Obradovic Z., Del Vecchio R.F., Almajid F., Barac A., Dragovac G., Pishmisheva-Peleva M., Rahman M.T., Rahman T., Le Marechal M., Cag Y., Ikram A., and Rodriguez-Morales A.J.

Subjects
Asia, Surveillance data, 030231 tropical medicine, education, Economic statu, Tick, Socioeconomic Factor, Zoonosis, 03 medical and health sciences, 0302 clinical medicine, Economic status, Zoonosi, Multidisciplinary approach, Zoonoses, Environmental health, medicine, Animals, Humans, Hemorrhagic Fever, Crimean, economic status, infection, tick, vector, zoonosis, Socioeconomic status, health care economics and organizations, Cross-Sectional Studie, 0303 health sciences, Zoonotic Infection, biology, Animal, 030306 microbiology, Significant difference, Public Health, Environmental and Occupational Health, An ID-IRI survey in 24 countries of Europe, Africa and Asia-, TRAVEL MEDICINE AND INFECTIOUS DISEASE, cilt.44, 2021 [Saydam F. N. , Erdem H., ANKARALI H., Ramadan M. E. E. , El-Sayed N. M. , Civljak R., Pshenichnaya N., Moroti R. V. , Mahmuodabad F. M. , Maduka A. V. , et al., -Vector-borne and zoonotic infections and their relationships with regional and socioeconomic statuses], medicine.disease, biology.organism_classification, 3. Good health, Europe, Cross-Sectional Studies, Infectious Diseases, Geography, Socioeconomic Factors, Vector (epidemiology), Africa, Hemorrhagic Fever Virus, Crimean-Congo, Vector, Infection
Abstract

Background: In this cross-sectional, international study, we aimed to analyze vector-borne and zoonotic infections (VBZI), which are significant global threats. Method: VBZIs’ data between May 20–28, 2018 was collected. The 24 Participatingcountries were classified as lower-middle, upper-middle, and high-income. Results: 382 patients were included. 175(45.8%) were hospitalized, most commonly in Croatia, Egypt, and Romania(P = 0.001). There was a significant difference between distributions of VBZIs according to geographical regions(P < 0.001). Amebiasis, Ancylostomiasis, Blastocystosis, Cryptosporidiosis, Giardiasis, Toxoplasmosis were significantly more common in the Middle-East while Bartonellosis, Borreliosis, Cat Scratch Disease, Hantavirus syndrome, Rickettsiosis, Campylobacteriosis, Salmonellosis in Central/East/South-East Europe; Brucellosis and Echinococcosis in Central/West Asia; Campylobacteriosis, Chikungunya, Tick-borne encephalitis, Visceral Leishmaniasis, Salmonellosis, Toxoplasmosis in the North-Mediterranean; CCHF, Cutaneous Leishmaniasis, Dengue, Malaria, Taeniasis, Salmonellosis in Indian Subcontinent; Lassa Fever in West Africa. There were significant regional differences for viral hemorrhagic fevers(P < 0.001) and tick-borne infections(P < 0.001), and according to economic status for VBZIs(P < 0.001). The prevalences of VBZIs were significantly higher in lower-middle income countries(P = 0.001). The most similar regions were the Indian Subcontinent and the Middle-East, the Indian Subcontinent and the North-Mediterranean, and the Middle-East and North-Mediterranean regions. Conclusions: Regional and socioeconomic heterogeneity still exists for VBZIs. Control and eradication of VBZIs require evidence-based surveillance data, and multidisciplinary efforts.

Published
2021

33. Surgical Precautions and Algorithmic Decision-Making for Surgical Procedures During the COVID-19 Pandemic

Author

Alper Yenigun, Nurtac Dagistanli, Arif Koytak, Orhan Ozturan, Meliha Meric Koc, YENİGÜN, ALPER, ÖZTURAN, ORHAN, MERİÇ KOÇ, MELİHA, and KOYTAK, İBRAHİM ARİF

Subjects
Operating Rooms, medicine.medical_specialty, 2019-20 coronavirus outbreak, Letter, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, COVID-19, Surgical precautions, Surgical procedures, Pandemic, medicine, Humans, Surgery, Intensive care medicine, business, Pandemics
Published
2020

34. Managing adult patients with infectious diseases in emergency departments: international ID-IRI study

Author

Cernat Roxana Carmen, Sholpan Kulzhanova, Yasemin Cag, Mohamed Elhassan Abbas Dafalla, Ozay Akyildiz, Amani El-Kholy, Ainur Sadykova, Ahmed Ashraf Wegdan, Anna Liskova, Jordi Rello, Fatma A. Amer, Ilyas Dokmetas, Behrouz Naghili, Natalia Dirani, Svjetlana Grgić, Michael M. Petrov, Sevil Alkan Ceviker, Jameela Alsalman, Jehan El-Kholy, Hakan Hasman, Serkan Oncu, Abu Hena Mostafa Kamal, Kalyan Koganti, Yasemin Yildiz-Kirazaldi, Mateja Jankovic Makek, Hulya Caskurlu, Rusmir Baljic, Selda Aslan, Razi Even Dar, Sergio Ramirez-Estrada, Mateja Logar, Cansu Bulut-Avsar, Joanna Zajkowska, Rosa Fontana Del Vecchio, Handan Alay, Aidos K Konkayev, Marzena Wojewodzka-Zelezniakowicz, Sally Hargreaves, Hakan Erdem, Amjad Mahboob, Ferran Llopis, Dumitru Irina Mgdalena, Ergys Ramosaco, Dilek Bulut, Ameen S. S. Alwashmi, Nikolay Mladenov, Esam Abdalla, Nirav Pandya, Lorenza Lambertenghi, Mustafa Altindiş, Hema Prakash Kumari, Andrea Marino, Yvon Ruch, Filiz Kizilates, Dirar Abdallah, Emine Kubra Dindar-Demiray, Antonio Cascio, Meliha Meric-Koc, Asiye Bahar-Kacmaz, Rehab H. El-Sokkary, Meltem Taşbakan, Ridvan Karaali, Handan Ankarali, Helena Monzón-Camps, Ilad Alavi-Darazam, Ghaydaa A. Shehata, Merve Sefa-Sayar, Fatma Kesmez-Can, Ege Üniversitesi, MERİÇ KOÇ, MELİHA, Erdem H., Hargreaves S., Ankarali H., Caskurlu H., Ceviker S.A., Bahar-Kacmaz A., Meric-Koc M., Altindis M., Yildiz-Kirazaldi Y., Kizilates F., Alsalman J., Cag Y., Kamal A.H.M., Dokmetas I., Dindar-Demiray E.K., Shehata G.A., Hasman H., Sadykova A., Llopis F., Ramosaco E., Logar M., Alay H., Kesmez-Can F., Ruch Y., Bulut D., Makek M.J., Marino A., Mahboob A., El-Kholy A., Abdallah D., Sefa-Sayar M., Karaali R., Aslan S., Dar R.E., Abdalla E., Monzon-Camps H., Baljic R., Mgdalena D.I., Naghili B., Abbas Dafalla M.E., Alwashmi A.S.S., Carmen C.R., Ramirez-Estrada S., Wojewodzka-Zelezniakowicz M., Akyildiz O., Zajkowska J., El-Sokkary R., Pandya N., Amer F., Alavi-Darazam I., Grgic S., Wegdan A.A., El-Kholy J., Bulut-Avsar C., Kulzhanova S., Tasbakan M., Kumari H.P., Dirani N., Koganti K., Konkayev A.K., Petrov M.M., Cascio A., Liskova A., Del Vecchio R.F., Lambertenghi L., Mladenov N., Oncu S., and Rello J.

Subjects
0301 basic medicine, Point prevalence survey, medicine.medical_specialty, Urologic Neoplasms, Referral, international ID-IRI study-, JOURNAL OF CHEMOTHERAPY, 2021 [Erdem H., Hargreaves S., ANKARALI H., ÇAŞKURLU H., Ceviker S. A. , Bahar-Kacmaz A., Meric-Koc M., ALTINDİŞ M., Yildiz-Kirazaldi Y., Kizilates F., et al., -Managing adult patients with infectious diseases in emergency departments], medicine.drug_class, Organ Dysfunction Scores, 030106 microbiology, Antibiotics, Practice Patterns, emergency, antibiotic, elderly, infection, sepsis, treatment, Global Health, Communicable Diseases, Sepsis, Hospital, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Practice Patterns, Physicians', Developing Countries, Respiratory Tract Infections, Pharmacology, Emergency Service, Physicians', Adult patients, business.industry, Patient Acuity, Antimicrobial, medicine.disease, humanities, Drug Utilization, Anti-Bacterial Agents, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, Emergency medicine, Emergency, sepsi, business, Emergency Service, Hospital
Abstract

We aimed to explore factors for optimizing antimicrobial treatment in emergency departments. A single-day point prevalence survey was conducted on January 18, 2020, in 53 referral/tertiary hospitals in 22 countries. 1957 (17%) of 11557 patients presenting to EDs had infections. The mean qSOFA score was 0.37 +/- 0.74. Sepsis (qSOFA >= 2) was recorded in 218 (11.1%) patients. The mean qSOFA score was significantly higher in low-middle (1.48 +/- 0.963) compared to upper-middle (0.17 +/- 0.482) and high-income (0.36 +/- 0.714) countries ( P < 0.001). Eight (3.7%) patients with sepsis were treated as outpatients. The most common diagnoses were upper-respiratory (n = 877, 43.3%), lower-respiratory (n = 316, 16.1%), and lower-urinary (n = 201, 10.3%) infections. 1085 (55.4%) patients received antibiotics. The most-commonly used antibiotics were beta-lactam (BL) and BL inhibitors (n = 307, 15.7%), third-generation cephalosporins (n = 251, 12.8%), and quinolones (n = 204, 10.5%). Irrational antibiotic use and inappropriate hospitalization decisions seemed possible. Patients were more septic in countries with limited resources. Hence, a better organizational scheme is required.

Published
2021

35. Diagnosis, treatment and prevention of infective endocarditis: Turkish consensus report-2019*

Author

Arif Atahan Çağatay, Nesrin Turhan, Ahmet Rüçhan Akar, Tuncay Hazirolan, Serap Simsek-Yavuz, Seniha Başaran, Meliha Meric-Koc, Hakan Demir, Murat Sargın, Elif Tükenmez-Tigen, Neziha Yılmaz, Yasemin Cag, Ayşegül Yeşilkaya, Emel Yilmaz, Nirgül Kılıçaslan, Mutlu Şeyda Velioğlu-Öcalmaz, Ayfer Şensoy, Şirin Menekşe, Mehmet Emirhan Işık, Lokman Hızmalı, Yeşim Uygun-Kızmaz, Necla Ozer, Güle Çınar Aydın, Serpil Öztürk, Sinan Aydoğdu, Denef Deniz, Mehmet Ali Özatik, Özlem Kurt Azap, Nursen Topcuoglu, Fatma Yilmaz-Karadag, Yasemin Tezer-Tekçe, Sibel Doğan Kaya, Mehmet Yilmaz, and MERİÇ KOÇ, MELİHA

Subjects
lcsh:Internal medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Consensus, Turkey, Turkish, Cardiology, MEDLINE, lcsh:Medicine, medicine, Humans, infective endocarditis, lcsh:RC31-1245, Intensive care medicine, Societies, Medical, consensus report, Endocarditis, business.industry, lcsh:R, medicine.disease, language.human_language, Diagnosis treatment, lcsh:RC666-701, Infective endocarditis, language, Cardiology and Cardiovascular Medicine, business
Abstract

Infective endocarditis (IE) is a rare but still important as an infectious disease due to high rate of morbidity and substantial mortality. Although IE is not a notifiable disease in Turkey, and an incidence study has not been performed, the incidence may be higher than that in the developed countries due to frequent predisposing cardiac conditions and higher rates of nosocomial bacteremia, which may lead to IE in risk groups. IE generally affects the elderly in developed countries but it is frequently encountered among young individuals in Turkey. In order to reduce mortality and morbidity, it is critical to diagnose IE, to determine the causative agent, and to start treatment rapidly. Most patients cannot be diagnosed at the first visit, about half can be diagnosed after 3 months, and the disease often goes unnoticed. In patients diagnosed with IE, the rate of the identification of a causative organism is significantly lower in Turkey than that in developed countries. Some important microbiological diagnostic tests are not performed in most centers and several antimicrobials that are recommended as the first option for the treatment particularly antistaphylococcal penicillins, are unavailable in Turkey. These problems necessitate reviewing the epidemiological, laboratory, and clinical characteristics of IE in our country, as well as the current information about its diagnosis, treatment, and prevention together with local data. The diagnosis and treatment processes of IE should be standardized at every stage so that the management can be conducted in a setting in which physicians of various specialties are involved and is consistent with the current recommendations. The Study Group for Infective Endocarditis and Other Cardiovascular Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases called for the collaboration of the relevant specialist organizations to establish a consensus report on the diagnosis, treatment, and prevention of IE in the context of current information and local data in Turkey.

Published
2020

36. International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

Author

Víctor Daniel Rosenthal, Hail M. Al-Abdely, Amani Ali El-Kholy, Safa A Aziz AlKhawaja, Hakan Leblebicioglu, Yatin Mehta, Vineya Rai, Nguyen Viet Hung, Souha Sami Kanj, Mona Foda Salama, Estuardo Salgado-Yepez, Naheed Elahi, Rayo Morfin Otero, Anucha Apisarnthanarak, Braulio Matias De Carvalho, Bat Erdene Ider, Dale Fisher, Maria Carmen S.G. Buenaflor, Michael M. Petrov, Ana Marcela Quesada-Mora, Farid Zand, Vaidotas Gurskis, Tanja Anguseva, Aamer Ikram, Daisy Aguilar de Moros, Wieslawa Duszynska, Nepomuceno Mejia, Florin George Horhat, Vladislav Belskiy, Vesna Mioljevic, Gabriela Di Silvestre, Katarina Furova, Gloria Y. Ramos-Ortiz, May Osman Gamar Elanbya, Hindra Irawan Satari, Umesh Gupta, Tarek Dendane, Lul Raka, Humberto Guanche-Garcell, Bijie Hu, Denis Padgett, Kushlani Jayatilleke, Najla Ben Jaballah, Eleni Apostolopoulou, Walter Enrique Prudencio Leon, Alejandra Sepulveda-Chavez, Hector Miguel Telechea, Andrew Trotter, Carlos Alvarez-Moreno, Luis Kushner-Davalos, J.E. Desse, D.M. Maurizi, A.M. Montanini, G.J. Chaparro, J.P. Stagnaro, A. Romani, A.C. Bianchi, G. Álvarez, A. Palaoro, M. Bernan, R. Cabrera-Montesino, C. Domínguez, C.G. Rodríguez, C.G. Silva, E. Bogdanowicz, F.O. Riera, G. Benchetrit, I. Perez, J. Vimercati, L.S. Marcos, L. Ramasco, M. Caridi, M.C. Oyola, M.C. Rodríguez, M.L. Spadaro, M.S. Olivieri, P. Saul, P.D. Juarez, R.H. Pérez, P. Botta, D.Q. Quintana, A.M. Ríos, V. Chediack, W. Chilon, Ameena Isa Alsayegh, Fatema Hasan Yaseen, Lateefa Fardan Hani, Saleh Fakher Sowar, Tahira Anwar Magray, E.A. Medeiros, A. Alves De Oliveira, A. Romario-Mendes, C. Fernandes-Valente, C. Santos, D. Escudeiro, D. Azevedo-Ferreira Lima, D. Azevedo-Pereira, E.M. Onzi-Siliprandi, F. Serpa-Maia, F. Aguiar-Leitao, G. Assuncao-Ponte, J. Dos Anjos-Lima, J. Olszewski, K. Harten Pinto Coelho, L.F. Alves De Lima, M. Mendonca, M.L. Maciel-Canuto Amaral, M.T. Tenorio, S. Gerah, M. Andrade-Oliveira-Reis, M. Moreira, M. Ximenes-Rocha Batista, R.S. Campos-Uchoa, R. Rocha-Vasconcelos Carneiro, R. Amaral De Moraes, S.C. Do Nascimento, T. Moreira-Matos, T.M. Lima-De Barros Araujo, T. De Jesus Pinheiro-Bandeira, V.L. Machado-Silva, W.M. Santos Monteiro, E. Hristozova, E.D. Kostadinov, K. Angelova, V.A. Velinova, V.J. Dicheva, X. Guo, G. Ye, R. Li, L. Song, K. Liu, T. Liu, G. Song, C. Wang, X. Yang, H. Yu, Y. Yang, A. Martínez, A.R. Vargas-García, A. Lagares-Guzmán, A.P. González, C. Linares, C. Ávila-Acosta, D. Santofimio, D. Yepes-Gomez, D.A. Marin-Tobar, D.P. Mazo-Elorza, E.G. Chapeta-Parada, G. Camacho-Moreno, G.E. Roncancio-Vill, I.A. Valderrama-Marquez, J.E. Ruiz-Gallardo, J.O. Ospina-Martínez, J. Osorio, J.I. Marín-Uribe, J.C. López, S. Gualtero, J.R. Rojas, K. Gomez-Nieto, L.Y.M. Rincon, L. Meneses-Ovallos, L.M. Canas-Giraldo, L.D. Burgos-Florez, M. Amaral-Almeida Costa, M. Rodriguez, N. Barahona-Guzmán, O. Mancera-Paez, P.A. Rios-Arana, R. Ortega, S.L. Romero-Torres, S.M. Pulido-Leon, S. Valderrama, V.M. Moreno-Mejia, W. Raigoza-Martinez, W. Villamil-Gomez, Y.A. Pardo-Lopez, A. Argüello-Ruiz, A. Solano-Chinchilla, G.A. Muñoz-Gutierrez, I. Calvo-Hernández, L. Maroto-Vargas, M.A. Zuniga, M. Valverde-Hernandez, O. Chavarria-Ugalde, B. Herrera, C. Díaz, M.M. Bovera, C. Cevallos, C. Pelaez, E. Jara, V. Delgado, E.E. Coello-Gordon, F. Picoita, F.M. Guerrero-Toapant, F. Valencia, G. Santacruz, H. Gonzalez, L.N. Pazmino, M.F. Garcia, M. Arboleda, M. Lascano, N. Alquinga, V. Ramírez, Reham H.A. Yousef, Abd El Moniem Moustafa, A. Ahmed, A.M. Elansary, Ahmad Mahmoud Ali, Ahmed Hasanin, Antoine Abdel Messih, Arwa Ramadan, B.A. El Awady, D.M. Hassan, Doaa Abd El Aziz, Hala Hamza, Hala Mounir Agha, Islam Abdullorziz Ghazi, J. ElKholy, May Abdel Fattah, Mervat Elanany, M. Mansour, M.M.A. Haleim, R. Fouda, Rasha Hamed El-Sherif, S. Bekeit, V. Bayani, Y.S. Elkholy, Y.M. Abdelhamid, Zeinab Salah, D.M. Rivera, A. Chawla, A.N. Manked, A. Azim, A. Mubarak, A. Thakur, A.V. Dharan, A. Patil, A. Sasidharan, Anil Kumar Bilolikar, A. Anirban Karmakar, A.M. Mathew, Anuja Kulkarni, Anuradha Agarwal, Anuradha Sriram, A. Dwivedy, Arnab Dasgupta, A. Bhakta, Arul Rose Suganya, A. Poojary, Ashwin Kumar Mani, Asmita Sakle, Babu K. Abraham, Baby Padmini, B. Ramachandran, Banambar Ray, Basanta Kumar Pati, Bhaskar Narayan Chaudhury, Biraj Mohan Mishra, S. Biswas, M. Bri Saibala, Burhan Q. Jawadwala, C. Rodrigues, Chirag Modi, Chirag Patel, D.K. Khanna, Dedeepiya Devaprasad, Deepa Divekar, Deepesh G. Aggarwal, J.V. Divatia, Dolatsinh Zala, Edwin Pathrose, Fazil Abubakar, Felcy Chacko, G.S. Gehlot, Gautam Khanna, H.K. Sale, Indranil Roy, Jayant Shelgaonkar, Jehangir Sorabjee, Jincy Eappen, Justin Mathew, Jyotishka Pal, Karthikeya Varma, Kashmira Limaye Joshi, Kavita Sandhu, R. Kelkar, Lakshmi Ranganathan, L. Pushparaj, Madhav Lavate, Madhavi Latha, Madhupriya Suryawanshi, M. Bhattacharyya, Maithili Kavathekar, Manoj Kumar Agarwal, Mayur Patel, Mehul Shah, M.N. Sivakumar, Mohit Kharbanda, Mrinmoy Bej, Mrunalini Potdar, M. Chakravarthy, M. Karpagam, S.N. Myatra, N. Gita, N.P. Rao, N. Sen, N. Ramakrishnan, N. Jaggi, N. Saini, N.K. Pawar, Nikhil Modi, Nirav Pandya, Nisith Mohanty, Pooja Thakkar, Pradnya Joshi, Prafulla Kumar Sahoo, Pravin Kumar Nair, Priyadarshini Senthil Kumar, Priyanka Patil, Purnima Mukherjee, P. Mathur, Purvi Shah, R. Sukanya, Rajalakshmi Arjun, Rajesh Chawla, Ram Gopalakrishnan, Ramesh Venkataraman, S. Raut, Ravikumar Krupanandan, Reshma Tejam, Richa Misra, Ritesh Debroy, S. Saranya, Sajith Narayanan, Sanghamitra Mishra, Sanjith Saseedharan, Sankar Sengupta, S.K. Patnaik, Saswati Sinha, Seelas Blessymole, Seema Rohra, Senthilkumar Rajagopal, Shanta Mukherjee, Sharmila Sengupta, Sheeba John, Shefali Bhattacharya, null Sijo, Sinchan Bhattacharyya, S. Singh, T. Sohanlal, Sonali Vadi, S.S. Dalal, S.K. Todi, Subodh Kumar, Sudha Kansal, Sudhjan Misra, Sudipta Bhattacharyya, Suhas Nirkhiwale, Sujit Kar Purkayastha, Sujoy Mukherjee, S. Sahu, Sunil Sharma, Suresh Kumar, S. Basu, S. Shetty, S. Shah, T. Singhal, Thara Francis, Thejasvini Anand, V. Venkateshwar, Valsa Thomas, V. Kothari, null Velupandi, Vini Kantroo, Gortap Sitohang, Retno Kadarsih, Anahita Sanaei, Behzad Maghsudi, Golnar Sabetian, Mansoor Masjedi, Masoud Alebouyeh, Somayeh Jahani Sherafat, Yassir Khidir Mohamed, Abdulrahim Al Khamis, Adnan Soliman Alsaadi, Ahmed Abdoh Al-Jarie, Aisha Hassan Mutwalli, A.S.K. Rillorta, Anumol Thomas, Ashraf Kelany, Athena Manao, Dhaffer Moghram Alamri, E.B. Santiago, E.P. Cruzpero, Fahad Ahmed Sawan, Fatima Abdullah Al Qasmah, Haeel Alabdaly, Hajer Am Al-Dossary, Hala Ahmed, Hala Roshdi, Halima Yahia Al-Alkami, Hana Hanafi, Hassan Eisa Ammari, Hatem Mohd Al Hani, Ibrahim A.M. Alzaydani Asiri, Jeffrey Asidera Mendoza, Jomol Philipose, Joy Ola Selga, null Kehkashan, Khalid Mohammed Ghalilah, Leide Shyrine Redito, L. Josph, M. Al-Alawi, Manal Mansour Al-Gethamy, Marjory Madco, M.G. Manuel, M. Girvan, Mervat Aldalaton, M. De Guzman, Modhi Alkhamaly, Mohammad Masfar, Mohammed Ahmed Ali Karrar, Munayfa Musallam Al Azmi, Myrna Lim Quisai, Myrna Misador Torres, N. Al-Abdullah, Nader Ahmed Tawfic, Nashwa Elsayed, Nawal Salah Abdulkhalik, Nehad Abdulshakour Bugis, Neilia Cardinal Ariola, N. Gad, Nesreen Alghosn, Nidal Tashkandi, N. Al Zharani, P.A. De Vera, Radhika Krishnan, Raed Hassan Al Shehri, Rasha Nour Aldeen Jaha, Reny Thomas, Rhea Lynn Cresencia, R. Penuliar, R.V. Lozada, S. Al Qahtani, Sameh Twfik, Sarah Hassan Al Faraj, Sherin El-Sherbiny, Siti Jhulmina B. Alih, Solita Briones, Syed Zahid Bukhari, Tariq Saad Abdulhadi Alotaibi, Uma Gopal, Usha Nair, Wael Abdulrahman Abdulatif, Waleed Mohd Hussain, Wynndale Mae Demotica, G. Spahija, N. Baftiu, A. Gashi, Abeer A. Omar, A.M. Mohamed, F.M. Rebello, Haifaa Hassan Almousa, Naglaa Mahmoud Abdo, S.M. George, Soad Khamis, Suja Thomas, A. Ahmad Zaatari, A. Anwar Al Souheil, H. Ayash, I. Zeid, J. Tannous, N.K. Zahreddine, R. Ahmadieh, T. Mahfouz, T. Kardas, V. Tanzi, Z. Kanafani, Z. Hammoud, A. Dagys, D. Grinkeviciute, R. Kevalas, T. Kondratas, Milena Petrovska, Katja Popovska, Zan Mitrev, Zaneta Bogoevska Miteva, Katerina Jankovska, Snezana Tufekcievska Guroska, Chin Seng Gan, Ainul Auzani Othman, Aliza Mohamad Yusof, Anis Siham Zainal Abidin, Fadzlina Abdul Aziz, Foong Kit Weng, Hasimah Zainol, Kamal Bashar Abu Bakar, Lucy Chai See Lum, Marzida Mansor, Mazuin Kamarul Zaman, Mohamad Fadhil Hadi Jamaluddin, Mohd Shahnaz Hasan, Raha Abdul Rahman, Rhendra Hardy Mohamad Zaini, Rosliza Zhazali, Sasheela Sri La Sri Ponnampala, Soo Lin Chuah, Wan Fadzlina Wan Mohd Shukeri, Wan Nazaruddin Wan Hassan, Wan Nurbayah Wan Yusoff, Wan Rahiza Wan Mat, M.A. Cureno-Diaz, G. Aguirre-Avalos, A. Flores-Alvarado, A. Cerero-Gudino, A. Zamores-Pedroza, B. Cano-Munoz, B.E. Hernandez-Chena, C.C. Carreon-Martinez, H. Coronado-Magana, F. Corona-Jimenez, E. Rodriguez-Noriega, E. Alcala-Martinez, E. Gonzalez-Diaz, F.M. Guerra-Infante, G. Arteaga-Troncoso, G. Martinez-Falcon, G. Leon-Garnica, H.A. Delgado-Aguirre, H.R. Perez-Gomez, I.E. Sosa-Gonzalez, J.A. Galindo-Olmeda, J.J. Ayala-Gaytan, J. Rodriguez-Pacheco, L. Zamorano-Flores, J.A. Lopez-Pulgarin, M.G. Miranda-Novales, M. Ramírez, M. Lopez-Hurtado, M. Lozano, M.E. Gomez, M.E. Sanchez-Castuera, M. Kasten-Monges, M. Gonzalez-Martinez, M. Sanchez-Vargas, M.C. Culebro-Burguet, M.A. Altuzar-Figueroa, J.C. Mijangos-Mendez, O.G. Ramires, O.S. Espinosa, R. De Leon-Escobedo, R. Salas-Flores, R. Ruiz-Rendon, S. Petersen-Morfin, S.A. Aguirre-Diaz, S. Esparza-Ahumada, S. Vega-Gonzalez, V. Gaona-Flores, V.A. Monroy-Colin, Z. Cruz-Rivera, A. Bat-Erdene, Batsaikhan Narankhuu, Batsuren Choijamts, Battsetseg Tuvdennyam, Byambadorj Batkhuu, K.H. Chuluunchimeg, D. Enkhtsetseg, G. Batjargal, G. Bayasgalan, M. Dorj, Naranpurev Mendsaikhan, Otgon Baatar, P. Suvderdene, S. Baigalmaa, T. Khajidmaa, Tsolmon Begzjav, null Tsuyanga, Z. Ariyasuren, A.A. Zeggwagh, K. Berechid, K. Abidi, N. Madani, R. Abouqal, Anjeela Koirala, Rashmi Giri, Samana Sainju, Subhash Prasad Acharya, Abeera Ahmed, Aun Raza, Azra Parveen, Faisal Sultan, Maria Khan, Nadeem Paul, Nargis Daud, Sana Yusuf, Summiya Nizamuddin, E. Garcia-Mayorca, E.G. Castaño, J.L. Moreno-Castillo, J.M. Ballinas-Aquino, L. Lara, M. Vargas, M.I. Rojas-Bonilla, S.J. Ramos, T. Mapp, V. De Iturrado, C.E. La Hoz Vergara, C.F. Linares-Calderon, D. Moreno, E. Ramirez, F.M. Ramírez Wong, G.M. Montenegro-Orrego, H.R. Sandoval-Castillo, J. Pichilingue-Chagray, J. Mueras-Quevedo, K.F. Aibar-Yaranga, L.I. Castillo-Bravo, L.M. Santivanez-Monge, M.J. Mayorga-Espichan, M.L.G. Rosario-Tueros, M.V. Changano-Rodriguez, N.E. Salazar-Ramirez, V.A. Marquez-Mondalgo, Anna Lyn N. Tajanlangit, Arnefelina S. Tamayo, Cristina Mari Jean P. Llames, Ever Labro, Ana P. Dy, J.D. Fortin, L.D. Bergosa, L.G. Salvio, V. Bermudez, M.C. Sg-Buenaflor, M.F. Trajano, M.T. Mendoza, O.P. Javellana, R.R. Maglente, Y. Arreza-Galapia, J.A. Navoa-Ng, A. Kubler, B. Barteczko-Grajek, B. Dragan, M. Zurawska, M. Mikaszewska-Sokolewicz, M. Zielinska, G.Y. Ramos-Ortiz, A. Florin-Rogobete, C. Daliborca Vlad, D. Muntean, D. Sandesc, M. Papurica, M. Licker, Ovidiu Horea Bedreag, R. Popescu, S.D. Grecu, V. Dumitrascu, A. Molkov, D. Galishevskiy, M. Furman, A. Simic, D. Lekic, G. Ristic, J. Eremija, J. Kojovic, L. Nikolic, M. Bjelovic, A. Lesnakova, S. Hlinkova, M.O. Gamar-Elanbya, Namphon Supa, Pornpheth Prasan, Rungratchanee Pimathai, Suthinee Wanitanukool, Suwara Somabutr, N. Ben-Jaballah, A. Borgi, A. Bouziri, A. Dilek, A. Oncul, A. Kaya, Ali Pekcan Demiroz, A. Gunduz, A. Ozgultekin, Asuman Inan, A.N. Yalcin, A. Ramazanoglu, A. Engin, A. Willke, Basak Ceyda Meco, C. Aygun, C. Bulut, C. Uzun, C. Becerik, Cigdem Ataman Hatipoglu, Cigdem Yildirim Guclu, D. Ozdemir, D. Yildizdas, D. Ugurcan, E. Azak, E. Guclu, Esmeray Mutlu Yilmaz, F. Sebnem-Erdinc, F. Sirmatel, F. Ulger, Ferhat Sari, Filiz Kizilates, G. Usluer, G. Ceylan, G. Ersoz, G. Kaya, Gunay Tuncer Ertem, G. Senol, Hasan Agin, Hatice Cabadak, H. Yilmaz, Hulya Sungurtekin, Humeyra Zengin, H. Turgut, I. Ozgunes, I. Devrim, I. Erdem, Inşa Gul Ekiz Işcanlı, M. Mehmet Bakir, M.F. Geyik, M. Oral, M. Meric, M. Cengiz, M. Ozcelik, M. Altindis, M. Sunbul, N. Elaldi, N. Kuyucu, N. Unal, N. Oztoprak, N. Yasar, Nurettin Erben, Nuri Bayram, Oguz Dursun, Oguz Karabay, O. Coskun, Ozden Ozgur Horoz, Ozge Turhan, Ozlem Sarac Sandal, Recep Tekin, Saban Esen, Selvi Yener Erdogan, Serhat Unal, Sevim Karacorlu, Suha Sen, Suzan Sacar, Volkan Yarar, Yeliz Oruc, Yusuf Sahip, Zeynep Kaya, Anamma Philip, Ashraf Elhoufi, Hussain Alrahma, E. Sachez, F. Perez, G.D. Empaire, H. Vidal, L. Montes-Bravo, M.E. Guzman Siritt, N. Orozco, N. Navarrete, Y. Ruiz, Z. Duran-Gil De Anez, Dang Thi Van Trang, Dao Quang Minh, Dao Xuan Co, Dinh Pham Phuong Anh, Le Thi Anh Thu, Le Thi Diem Tuyet, Le Thi Thu Nguyet, Ngo uy Chau, Nguyen Gia Binh, Nguyen Phuc Tien, Nguyen Quoc Anh, Phan Thi Hang, Tran Thi My Hanh, Tran Thi Thuy Hang, Truong Anh Thu, Vo Thi Hong Thoa, Ondokuz Mayıs Üniversitesi, and MERİÇ KOÇ, MELİHA

Subjects
Male, 0301 basic medicine, Pediatrics, Imipenem, Antibiotic resistance, Epidemiology, health care facilities, manpower, and services, Ceftazidime, Global Health, 0302 clinical medicine, Bloodstream infection, Prospective Studies, 030212 general & internal medicine, Child, Aged, 80 and over, Cross Infection, Urinary tract infection, Incidence, Health Policy, Ventilator-associated pneumonia, Middle Aged, Intensive Care Units, Infectious Diseases, Amikacin, Child, Preschool, Limited resources countries, Female, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Health care-associated infection, 030106 microbiology, Catheter-associated urinary tract infection, Developing countries, Young Adult, 03 medical and health sciences, Intensive care, medicine, Humans, Hospital infection, Aged, business.industry, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Device use, Nosocomial infection control, medicine.disease, Emergency medicine, Central line-associated bloodstream infections, business
Abstract

Hasan, M. Shahnaz/0000-0002-7493-7416; Abouqal, Redouane/0000-0002-6117-4341; Altindis, Mustafa/0000-0003-0411-9669; Masjedi, Mansoor/0000-0001-6175-9289; Popescu, Roxana/0000-0002-9387-1141; Mikaszewska-Sokolewicz, Malgorzata A/0000-0002-1148-7817; Meco, Basak Ceyda/0000-0003-2951-9634; Kumar, Perikala Vijayananda/0000-0001-8315-7000; Zand, Farid/0000-0003-3489-3372; Maghsoudi, Behzad/0000-0002-1279-8799; KAMARUL ZAMAN, MAZUIN/0000-0002-7920-6399; Gan, Chin Seng/0000-0002-6758-4798; Horoz, Ozden Ozgur/0000-0001-7590-650X; Medeiros, Eduardo A/0000-0002-6205-259X; Sabetian, Golnar/0000-0001-8764-2150; UNAL, SERHAT/0000-0003-1184-4711; Gan, Chin Seng/0000-0002-6758-4798; Delia, Muntean/0000-0001-9100-4530; Yalcin, Ata Nevzat/0000-0002-7243-7354; Leblebicioglu, Hakan/0000-0002-6033-8543; Horhat, Florin George/0000-0001-6133-0204; Yousef, Reham H. A./0000-0003-4004-3008; Delgado Aguirre, Hector Alberto/0000-0001-5448-7975; El Kholy, Amani/0000-0002-0645-7664; Rodriguez Ferrer, Marena Luz/0000-0002-8053-8454; Sanaei Dashti, Anahita/0000-0002-2827-3575; KARABAY, OGUZ/0000-0003-1514-1685; Barahona G., Nayide/0000-0003-3559-6900; Stagnaro, Juan Pablo/0000-0003-3836-9957; Alexandru Florin, Rogobete/0000-0003-1286-4431; KAYA, ZEYNEP/0000-0002-8468-2103; Dragan, Barbara/0000-0003-3108-4211; alvarez Moreno, carlos Arturo/0000-0001-5419-4494; Gonzalez Martinez, Marisela del Rocio/0000-0003-1474-736X; Jayatilleke, Kushlani/0000-0002-3931-6630; Unal, Necmettin/0000-0002-9440-7893; Duszynska, Wieslawa/0000-0002-5880-4904; Ngo, Quy Chau/0000-0002-6787-2757; Elmanakhly, Arwa/0000-0001-8557-0536; yildizdas, dincer/0000-0003-0739-5108; Kanj, Souha/0000-0001-6413-3396; Gupta, Umesh/0000-0001-7717-1404 WOS: 000392626300014 PubMed: 27742143 Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DAHAI), we collected prospective data from861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days. Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central lineassociated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheterassociated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs. Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically. (C) 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. VDR; Foundation to Fight against Nosocomial Infections The funding for design, development, maintenance, technical support, data validation, and report generation of the Surveillance Online System, and the activities carried out at International Nosocomial Infection Control Consortium headquarters, were provided by VDR and the Foundation to Fight against Nosocomial Infections.

Published
2016

37. Impact of switching to E/C/F/TAF on lipid profile and renal function in HIV-infected patients

Author

Mete, B., Gunduz, A., Zerdali, E., Senoglu, S., BOLUKÇU, SİBEL, Nakir, I. Yilmaz, Karaosmanoglu, H. Kumbasar, Koc, MELİHA, Bilge, B., Dokmetas, I., Tabak, F., and MERİÇ KOÇ, MELİHA

Subjects
Mete B., Gunduz A., Zerdali E., Senoglu S., BOLUKÇU S., Nakir I. Y. , Karaosmanoglu H. K. , Koc M., Bilge B., Dokmetas I., et al., -Impact of switching to E/C/F/TAF on lipid profile and renal function in HIV-infected patients-, HIV MEDICINE, cilt.20, ss.87-88, 2019
Published
2019

38. Hand Hygiene Compliance in Some Intensive Care Units of Turkey: Results of Multicentre Asklepeion Study

Author

Gül Durmuş, Sercan Ulusoy, Meliha Meriç Koç, Bilgin Arda, Emel Azak, Oğuz Reşat Sipahi, Cigdem Ataman Hatipoglu, Ramazan Gözüküçük, Filiz Koc, Nilgiin Deniz Kucuker, Nurhayat Kepeli, Nilay Bilgili Korkmaz, Derya Caglayan, Behiye Ulusoy, Kenan Ugurlu, Hilal Sipahi, Sevil Alkan Çeviker, Habibe Tülin Elmaslar Mert, Firdevs Aksoy, Gunes Senol, Handan Alay, Aye Uyan Onal, Hüsnü Pullukçu, Demet Dikis, Emine Sehmen, Sukran Askit Barik, MERİÇ KOÇ, MELİHA, and Ege Üniversitesi

Subjects
Results of Multicentre Asklepeion Study-, MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, cilt.7, 2018 [Onal A. U. , AKSOY F., Azak E., Koc M., Ceviker S. A. , Hatipoglu C. A. , Gozukucuk R., Sehmen E., Ugurlu K., Senol G., et al., -Hand Hygiene Compliance in Some Intensive Care Units of Turkey], Microbiology (medical), hospital-acquired infections, General Immunology and Microbiology, business.industry, media_common.quotation_subject, lcsh:R, lcsh:Medicine, nosocomial, infection control and prevention, medicine.disease, lcsh:Infectious and parasitic diseases, Compliance (psychology), Infectious Diseases, healthcare-associated infections, Hygiene, Intensive care, medicine, epidemiology, lcsh:RC109-216, Medical emergency, business, media_common
Abstract

WOS: 000463053800027, Introduction: Hand hygiene is one of the most cost-effective infection control measures. In this multicenter Study we analysed the hand hygiene compliance observation results of 15 hospitals in Turkey. Materials and Methods: This study was performed in intensive care units (ICUs) of 15 hospitals (Eight terriary-care educational hospitals, six state hospitals and one private hospital) from 11 cities from six regions of Turkey The observations were made by infection control practitioners according to the World Health Organization - Five Moments for Hand Hygiene (WHO-5) indications rule for hand hygiene and overall compliance rates were calculated. Observations were unblinded (healthcare professionals knew that they were observed). The study period included 2015 and 2016 calendar years. Results: There was a statistically significant increase in hand hygiene compliance rates in 2016 versus 2015. The overall number of hand hygiene indications and compliance in 2015 and 2016 were 60071/78116-76,9% and 66551/83607-79,6% (p=0.0001), respectively. Nurses were the most compliant group in both years. The highest compliance was in after body fluid exposure indication (88.2%-2015 and 91.4%-2016) while the lowest compliance was in before patient contact indication (61.3%-2015 and 65%-2016). Conclusion: The presented data suggest that under unblinded observations, hand hygiene compliance seems to be in relatively acceptable rates in Turkey. Centers with compliance rates below 50 percentile rates in any of the 5 moments should increase efforts to enhance compliance in that indication.

Published
2019

39. Portraying infective endocarditis

Author

Ilker Inanc Balkan, Najada Como, André Silva-Pinto, Antonio Cascio, Canan Agalar, Meliha Meric-Koc, Tatjana Lejko Zupanc, Oday Abu Ajamieh, Simin Aysel Florescu, Selma Tosun, Meltem Taşbakan, Asuman Inan, Rosa Fontana Del Vecchio, Edmond Puca, Güven Çelebi, Ayse Sagmak-Tartar, Abdullah Umut Pekok, Yasemin Cag, Gülden Ersöz, Sumeyra Karakus, Safak Ozer-Balin, Jamal Wadi, Sukran Kose, Yves Hansmann, Hacer Deniz Ozkaya, Nefise Oztoprak, Hakan Erdem, Serkan Oncu, Jesper Damsgaard Gunst, Yvon Ruch, Aysegul Erdem, Gilda Tonziello, Ayse Batirel, Rahmet Guner, Irina Magdalena Dumitru, Lurdes Santos, Raquel Duro, Nesrin Ghanem-Zoubi, Arjeta Dedej, Serda Gulsun, Mustafa Dogan, Necla Tulek, Alper Şener, Pedro Palma Martins, Ilkay Bozkurt, Deborah Konopnicki, Fatma Sirmatel, Xavier Argemi, Meltem Avci, Fahad Almajid, Recep Tekin, Nicola Petrosillo, Corneliu Petru Popescu, Ayse Kaya-Kalem, Imran Hasanoglu, Atilla Iyisoy, Jean Philippe Mazzucotelli, Ejaz Ahmed Khan, Sema Sarı, Derya Ozturk-Engin, Nicolas Dauby, Erdem H., Puca E., Ruch Y., Santos L., Ghanem-Zoubi N., Argemi X., Hansmann Y., Guner R., Tonziello G., Mazzucotelli J.-P., Como N., Kose S., Batirel A., Inan A., Tulek N., Pekok A.U., Khan E.A., Iyisoy A., Meric-Koc M., Kaya-Kalem A., Martins P.P., Hasanoglu I., Silva-Pinto A., Oztoprak N., Duro R., Almajid F., Dogan M., Dauby N., Gunst J.D., Tekin R., Konopnicki D., Petrosillo N., Bozkurt I., Wadi J., Popescu C., Balkan I.I., Ozer-Balin S., Zupanc T.L., Cascio A., Dumitru I.M., Erdem A., Ersoz G., Tasbakan M., Ajamieh O.A., Sirmatel F., Florescu S., Gulsun S., Ozkaya H.D., Sari S., Tosun S., Avci M., Cag Y., Celebi G., Sagmak-Tartar A., Karakus S., Sener A., Dedej A., Oncu S., Del Vecchio R.F., Ozturk-Engin D., Agalar C., Virulence Bactérienne Précoce : fonctions cellulaires et contrôle de l'infection aigüe et subaigüe, Université de Strasbourg (UNISTRA), Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), MERİÇ KOÇ, MELİHA, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Uşak Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sırmatel, Fatma, and OMÜ

Subjects
Male, Internationality, Aucun, Infective endocarditi, medicine.disease_cause, Medical microbiology, 80 and over, Blood culture, Hospital Mortality, Aged, 80 and over, medicine.diagnostic_test, biology, Endocarditis, Bacterial, General Medicine, Sciences bio-médicales et agricoles, Middle Aged, Staphylococcal Infections, Sciences du Vivant [q-bio]/Microbiologie et Parasitologie, Viridans Streptococci, Catheter, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Staphylococcus aureus, Infective endocarditis, Aortic Valve, Mitral Valve, Female, Microbiology (medical), Adult, medicine.medical_specialty, Prosthesis-Related Infections, Adolescent, aureus, Young Adult, Internal medicine, medicine, Humans, results of multinational ID-IRI study-, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, cilt.38, ss.1753-1763, 2019 [Erdem H., Puca E., Ruch Y., Santos L., Ghanem-Zoubi N., Argemi X., Hansmann Y., Guner R., Tonziello G., Mazzucotelli J., et al., -Portraying infective endocarditis], Prosthetic, Aged, Native Valve Endocarditis, Bacteria, business.industry, Endocarditis, Bacterial, medicine.disease, biology.organism_classification, S. aureus, Viridans streptococci, business, Native
Abstract

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042)., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

40. Comparison of brucellar and tuberculous spondylodiscitis patients: results of the multicenter 'Backbone-1 Study'

Author

Tumer Guven, Hakan Erdem, Rehab H. El-Sokkary, Dilara Inan, Serda Gulsun, Fatma Yilmaz-Karadag, Gunay Tuncer-Ertem, Elif Sahin Horasan, Şafak Kaya, Ali İrfan Baran, Recep Tekin, Archontoula Fragou, Seniha Senbayrak, Esra Arslanalp, Fatma Sirmatel, Selçuk Kaya, Ayşe Willke, Salih Cesur, Sani H. Aliyu, Ergys Ramosaco, Meliha Meric-Koc, Meltem Taşbakan, Sukran Kose, Gönül Aslan, Efthymia Giannitsioti, Gonul Sengoz, Haluk Vahaboglu, Nazif Elaldi, Selma Ates-Guler, Birgul Mete, Sesin Kocagöz, Hulya Kusoglu, Ertugrul Guclu, Dilek Yildiz Sevgi, Hava Yilmaz, Gulfem Akengin Ocal, Ayse Batirel, Behiye Dede, Birsen Cetin, Tunc Oktenoglu, D. Ashraf ALGallad, Mehmet Ulug, Sebnem Senol, Banu Karaca, Ilker Inanc Balkan, Aygul Dogan-Celik, Nural Bekiroglu, Gonul Cicek-Senturk, Filiz Pehlivanoglu, Asuman Inan, MERİÇ KOÇ, MELİHA, Erdem, H, Elaldi, N, Batirel, A, Aliyu, S, Sengoz, G, Pehlivanoglu, F, Ramosaco, E, Gulsun, S, Tekin, R, Mete, B, Balkan, II, Sevgi, DY, Giannitsioti, E, Fragou, A, Kaya, S, Cetin, B, Oktenoglu, T, DoganCelik, A, Karaca, B, Horasan, ES, Ulug, M, Man, A, Arslanalp, E, Ates-Guler, S, Willke, A, Senol, S, Inan, D, Guclu, E, Tuncer-Ertem, G, Meric-Koc, M, Tasbakan, M, Senbayrak, S, Cicek-Senturk, G, Sirmatel, F, Ocal, G, Kocagoz, S, Kusoglu, H, Guven, T, Baran, AI, Dede, B, Yilmaz-Karadag, F, Kose, S, Yilmaz, H, Asian, G, Algallad, DA, Cesur, S, El-Sokkary, R, Bekiroglu, N, Vahaboglu, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Güçlü, Ertuğrul, [Erdem, Hakan] Culhane Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Batirel, Ayse -- Ocal, Gulfem] Dr Lao Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Aliyu, Sani] Cambridge Univ Hosp Fdn Trust, Addenbrookes Hosp, Clin Microbiol & Publ Hlth Lab, Cambridge, England -- [Sengoz, Gonul -- Pehlivanoglu, Filiz] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ramosaco, Ergys] Univ Hosp Ctr Mother Teresa, Infect Dis Hosp, Tirana, Albania -- [Gulsun, Serda -- Kaya, Safak] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Tekin, Recep] Dicle Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Mete, Birgul -- Balkan, Ilker Inanc] Istanbul Univ, Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Sevgi, Dilek Yildiz] Sisli Etfal Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Giannitsioti, Efthymia -- Fragou, Archontoula] Attikon Univ Gen Hosp, Athens Univ Med Sch, Dept Internal Med, Athens, Greece -- [Kaya, Selcuk] Karadeniz Tech Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Trabzon, Turkey -- [Cetin, Birsen] Koc Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Oktenoglu, Tune] Koc Univ, Sch Med, Dept Neurosurg, Istanbul, Turkey -- [DoganCelik, Aygul] Trakya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Edirne, Turkey -- [Karaca, Banu] Izmir Bozyaka Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Horasan, Elif Sahin] Mersin Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Ulug, Mehmet] Private Umit Hosp, Dept Infect Dis & Clin Microbiol, Eskisehir, Turkey -- [Man, Asuman -- Senbayrak, Seniha] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Arslanalp, Esra -- Willke, Ayse -- Meric-Koc, Meliha] Kocaeli Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Kocaeli, Turkey -- [Ates-Guler, Selma] Kahramanmaras Sutcu Imam Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-46050 Kahramanmaras, Turkey -- [Senol, Sebnem] Celal Bayar Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Manisa, Turkey -- [Inan, Dilara] Akdeniz Univ, Sch Med, Dept Infect Dis & Clin Microbiol, TR-07058 Antalya, Turkey -- [Guclu, Ertugrul] Sakarya Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Tuncer-Ertem, Gunay -- Cesur, Salih] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Tasbakan, Meitem] Ege Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Cicek-Senturk, Gonul -- Asian, Gonul] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Sirmatel, Fatma] Abant Izzet Baysal Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bolu, Turkey -- [Kocagoz, Sesin -- Kusoglu, Hulya] Acibadem Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Guven, Turner] Ankara Ataturk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Baran, Ali Irfan] Yuzuncu Yil Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Van, Turkey -- [Dede, Behiye] Umraniye Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz-Karadag, Fatma -- Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kose, Sukran] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Algallad, D. Ashraf -- El-Sokkary, Rehab] Zagazig Univ Hosp, Infect Control Unit, Az Zagazig, Egypt -- [Bekiroglu, Nural] Marmara Univ, Sch Med, Dept Biostat, Istanbul, Turkey, VAHABOGLU, Haluk -- 0000-0001-8217-1767, and Ondokuz Mayıs Üniversitesi

Subjects
Adult, Male, Spondylodiscitis, endocrine system, medicine.medical_specialty, Discitis, Constitutional symptoms, Context (language use), Brucellosis, Sequelae, Internal medicine, medicine, Back pain, Humans, Tuberculosis, Orthopedics and Sports Medicine, Abscess, Outcome, Aged, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Surgery, Orthopedics, Erythrocyte sedimentation rate, Female, Neurology (clinical), medicine.symptom, Complication, business
Abstract

WOS: 000366655100045, PubMed ID: 26386176, BACKGROUND CONTEXT: No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. PURPOSE: This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. STUDY DESIGN: A retrospective, multinational, and multicenter study was used. PATIENT SAMPLE: A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. OUTCOME MEASURES: The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. METHODS: Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. RESULTS: The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p

Published
2015

41. Are Soap, Paper Towel and Alcohol-based Disinfectants Easily Accessible in Intensive Care Units in Turkey?: Results of the Phokai Study

Author

Türkkan Öztürk Kaygusuz, Oğuz Sipahi, Mustafa Dogan, Erdem Güven, Feride Kocak, S Alkan Ceviker, Derya Caglayan, Firdevs Aksoy, Yeşim Kürekçi, Metin Arslan, G Evik, Güven Çelebi, S Cagan Aktas, N Dogan, Ramazan Gözüküçük, Fatih Koc, Kenan Ugurlu, Burak Özdemir, Selçuk Özger, ME Isik, Ayşe Uyan, Sema Sarı, Fethiye Akgül, Rezan Harman, Handan Alay, B Isik, Hilal Sipahi, S Ozkoren Calik, Ilknur Esen Yildiz, Gunes Senol, Kevser Ozdemir, Gül Durmuş, Meliha Meriç Koç, HT Elmaslar Mert, Bilgin Arda, Nefise Oztoprak, Hamza Erdogan, Nurbanu Sezak, Aslıhan Demirel, A Ozgultekin, Tansu Yamazhan, Mehmet Uçar, Sercan Ulusoy, EK Dindar Demiray, G Unsal, Ahsen Oncul, [Uyan, Ayse -- Yamazhan, Tansu -- Arda, Bilgin -- Ulusoy, Sercan -- Sipahi, Oguz Resat] Ege Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Izmir, Turkey -- [Durmus, Gul] Bursa Yuksek Ihtisas Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Bursa, Turkey -- [Sezak, Nurbanu] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ozdemir, Burcu] Ankara Numune Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Ankara, Turkey -- [Kaygusuz, Turkkan] Elazig Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Elazij, Turkey -- [Oztoprak, Nefise] Antalya Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Antalya, Turkey -- [Ozdemir, Keyser] Pamukkale Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Denizli, Turkey -- [Aksoy, Firdevs] Karadeniz Tech Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Trabzon, Turkey -- [Ozgultekin, Asu] Haydarpasa Numune Training & Res Hosp, Clin Anesthesiol & Intens Care, Istanbul, Turkey -- [Koc, Meliha Meric] Kocaeli Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Kocaeli, Turkey -- [Oncul, Ahsen] Sisli Etfal Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Cagan Aktas, Sabahat] Dr Lutfi Kirdar Kartal Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Isik, Burcu] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Celebi, Giiven] Bulent Ecevit Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Zonguldak, Turkey -- [Evik, Guliiz] Mersin Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Mersin, Turkey -- [Ozger, Selcuk] Dr Ersin Arslan Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Harman, Rezan] Private Sani Konukoglu Hosp, Clin Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Dindar Demiray, Emine Kubra] Celal Bayar Univ, Dept Infect Dis & Clin Microbiol, Fac Med, Manisa, Turkey -- [Ozkoren Calik, Sebnem] Izmir Bozyaka Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Izmir, Turkey -- [Alkan Ceviker, Sevil] Balikesir State Hosp, Clin Infect Dis & Clin Microbiol, Balikesir, Turkey -- [Yildiz, Ilknur Esen] Recep Tayyip Erdogan Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Rize, Turkey -- [Isik, Mehmet Emirhan] Kartal Kosuyolu Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Senol, Gunes] Dr Suat Seren Chest Dis & Chest Surg Training & R, Clin Infect Dis & Clin Microbiol, Izmir, Turkey -- [Sari, Sema] Turkiye Yuksek Ihtisas Hosp, Clin Intens Care, Ankara, Turkey -- [Dogan, Mustafa] Corlu State Hosp, Clin Infect Dis & Clin Microbiol, Tekirdag, Turkey -- [Ugurlu, Kenan] 25 Aralik & State Hosp, Clin Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Arslan, Mustafa] Amasya Univ, Sabuncuoglu Serefeddin Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Amasya, Turkey -- [Akgul, Fethiye] Batman State Hosp, Clin Infect Dis & Clin Microbiol, Batman, Turkey -- [Koc, Filiz] Kecioren Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Ankara, Turkey -- [Kurekci, Yeim] Arnavutkoy State Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Caglayan, Derya] Torbali State Hosp, Clin Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ucar, Mehmet] Usak Med Pk Hosp, Clin Infect Dis & Clin Microbiol, Usak, Turkey -- [Gozukucuk, Ramazan] Private Hisar Intercontinental Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elmaslar Mert, Habibe Tulin] Ardahan State Hosp, Clin Infect Dis & Clin Microbiol, Ardahan, Turkey -- [Alay, Handan] Nenehatun Obstet & Gynecol Hosp, Clin Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Erdogan, Haluk] Baskent Univ, Alanya Med & Res Ctr, Dept Infect Dis & Clin Microbiol, Antalya, Turkey -- [Demirel, Aslihan] Istanbul Bilim Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Dogan, Nilgun] TOBB Univ Econ & Technol Hosp, Hosp Infect Control Comm, Ankara, Turkey -- [Kocak, Funda] Basaksehir State Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Guven, Emre] Beytepe Murat Erdi Eker State Hosp, Clin Infect Dis & Clin Microbiol, Ankara, Turkey -- [Unsal, Guieser] Bozok Univ, Hosp Infect Control Comm, Fac Med, Yozgat, Turkey -- [Sipahi, Hilal] Bornova Publ Hlth Ctr, Izmir, Turkey, MERİÇ KOÇ, MELİHA, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yıldız, İlknur Esen, Zonguldak Bülent Ecevit Üniversitesi, and Ege Üniversitesi

Subjects
Microbiology (medical), SOAP, computer.internet_protocol, intensive care units, lcsh:Medicine, alcohol based disinfectants, Alcohol based disinfectants, Soap, lcsh:Infectious and parasitic diseases, paper towel, Intensive care, medicine, nosocomial infections, lcsh:RC109-216, Results of the Phokai Study-, MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, cilt.7, 2018 [Uyan A., Durmus G., Sezak N., Ozdemir B., Kaygusuz T., Oztoprak N., Ozdemir K., AKSOY F., Ozgultekin A., Koc M., et al., -Are Soap, Paper Towel and Alcohol-based Disinfectants Easily Accessible in Intensive Care Units in Turkey?], Intensive care units, General Immunology and Microbiology, lcsh:R, Paper towel, medicine.disease, Infectious Diseases, Medical emergency, Business, computer
Abstract

Introduction: Hand hygiene is one of the most effective infection control measures to prevent the spread of healthcare-associated infections (HCAI). Water, soap, paper towel and hand disinfectant must be available and adequate in terms of effective hand hygiene. The adequacy of hand hygiene products or keeping water-soap and paper towel is still a problem for many developing countries like Turkey. In this multicenter study, we analyzed the adequacy in number and availability of hand hygiene products., Materials and Methods: This study was performed in all intensive care units (ICUs) of 41 hospitals (27 tertiary-care educational, 10 state and four private hospitals) from 22 cities located in seven geographical regions of Turkey. We analyzed water, soap, paper towel and alcohol-based hand disinfectant adequacy on four different days, two of which were in summer during the vacation time (August, 27th and 31st 2016) and two in autumn (October, 12th and 15th 2016)., Results: The total number of ICUs and intensive care beds in 41 participating centers were 214 and 2357, respectively. Overall, there was no soap in 3-11% of sinks and no paper towel in 10-18% of sinks while there was no alcohol-based hand disinfectant in 1-4.7% of hand disinfectant units on the observation days. When we compared the number of sinks with soap and/or paper towel on weekdays vs. weekends, there was no significant difference in summer. However, on autumn weekdays, the number of sinks with soap and paper towel was significantly lower on weekend days (p, Conclusion: There should be adequate and accessible hand hygiene materials for effective hand hygiene. In this study, we found that soap and paper towels were inadequate on the observation days in 3-11% and 10-18% of units, respectively. Attention should be paid on soap and paper towel supply at weekends as well.

Published
2018

42. Kronik hepatit B hastalarında tiyol-disülfit homeostazı ve iskemi modifiye albümin düzeylerinin değerlendirilmesi

Author

Yildir, Nuray, Meriç Koç, Meliha, and Klinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı

Subjects
Thiols, Clinical Microbiology and Infectious Diseases, Ischemia-modified albumin, Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları, Homeostasis, Disulfides, Hepatitis B, Hepatitis
Abstract

Giriş-Amaç: Dünyada milyonlarca kişiyi enfekte ettiği bilinen kronik hepatit B enfeksiyonunun patolojisinde, reaktif oksijen türlerinin yol açtığı oksidatif stresin, ilerleyici karaciğer hasarı ve malignite gelişimine katkı sağladığı bilinmektedir. Tiyoller, sülfhidril grubu (-SH) içeren bir organik bileşiklerdir. Oksidatif strese karşı koruyucu olduğu bilinen tiyol bağları reaktif oksijen türleri ile karşılaştığında disülfit (-SS-) bağlarının oluşumuna neden olur, bu oluşum geri dönüşümlüdür ve ölçülebilir. Tiyol-disülfit homeostazının çeşitli kronik hastalıklarda değiştiği yapılan çalışmalarda gösterilmiştir. İskemi modifiye albümin (İMA) ise myokard iskemisi sonucu oksidatif stresin neden olduğu ağır metal bağlama özelliğini kaybeden serum albümin formudur. Son yıllarda yapılan çalışmalarda İMA düzeylerinin diğer kronik hastalıklarda da arttığı gösterilmiştir. Literatür taramalarımızda kronik hepatit B hastalarında tiyol-disülfit homeostazı ve İMA düzeylerinin birlikte değerlendirildiği bir çalışmaya rastlanmamıştır. Bu çalışmada, kronik hepatit B hastalarında tiyol-disülfit homeostazı ve İMA serum düzeylerinin normal popülasyona göre değişiminin incelenmesi, takip, tedavi kararı ve prognozu öngörmedeki yararları açısından değerlendirilmesi amaçlanmıştır.Materyal-Metot: Çalışmaya 79 kronik hepatit B hastası ve 51 sağlıklı kontrol olmak üzere toplam 130 hasta alınmıştır. Hastaların demografik verileri ve laboratuvar sonuçları kaydedilmiştir. Hasta ve sağlıklı kontrol grubundan alınan serum örneklerinde, Erel ve Neşelioğlu tarafından tarif edilmiş otomatize spektrofotometrik metotla total tiyol, nativ tiyol, disülfit miktarı ölçülmüş, disülfit/nativ tiyol, disülfit/total tiyol, nativ tiyol/total tiyol oranları da hesaplama yöntemi ile elde edilmiştir. İMA düzeyi albümin kobalt bağlama testi ile ölçülmüştür.Bulgular: Çalışmaya alınan hastalarda native tiyol ve total tiyol düzeyleri hasta grubunda anlamlı olarak düşük bulunmuştur (sırasıyla; p=0,0001, p=0,002). Hasta ve kontrol grubu arasında disülfit değeri açısından istatistiksel olarak anlamlı fark saptanmamıştır (p=0,6). Ayrıca hesaplama ile elde edilen disülfit/nativ tiyol, disülfit/total tiyol, nativ tiyol/total tiyol oranlarında gruplar arasında anlamlı fark saptanmamıştır. Hasta grubunda İMA düzeyi ortalaması kontrol grubuna göre yüksek saptanmış ve bu fark istatistiksel olarak anlamlı bulunmuştur (p=0,0001). İMA ile total tiyol/nativ tiyol arasında negatif yönde kuvvetli korelasyon olduğu görülmüştür. Pearson korelasyon analizlerinde; hasta grubunda yaş, cinsiyet, HBV DNA, ALT, biyopsi nekroz ve fibroz skorları ile native tiyol, total tiyol, disülfit, İMA değerleri arasında kuvvetli korelasyon saptanmamıştır. Sonuç: Hasta grubunda total tiyol, nativ tiyol ve İMA değerleri kontrol grubuna göre belirgin azalmış olarak saptanmıştır. Disülfit değerleri için aynı yorum yapılamamıştır. Viral yük, karaciğerin nekroinflamasyon ve fibrozis derecesi ile bu değerler arasında kuvvetli ilişki saptanmamıştır. Sonuç olarak bu çalışma KHB'li hastalarda antioksidan kapasitenin azaldığını ancak hastalığın şiddetini belirlemede bu belirteçlerin yetersiz olduğunu göstermiştir. Bu konuda daha geniş hasta grupları ile yapılacak çalışmalara ihtiyaç vardır. Introduction: It is known that oxidative stress caused by reactive oxygen species contributes to progressive liver damage and malignancy in the pathogenesis of chronic hepatitis B infection that affects millions of people in the world. Thiols are organic compounds containing a sulfhydryl group (-SH). Thiol bonds, protective against oxidative stress, produce disulfide bonds when react with reactive oxygen species, which can be reversible and measured. Recent studies have shown that thiol-disulfide homeostasis can change in various chronic diseases. Ischemia modified albümin (IMA) is a form of serum albumin reduced binding affinty to heavy metal ions due to oxidative stress after myocardial ischemia. Recent studies have shown that levels of IMA increased in other chronic diseases. In our literature review we did not find a cohort study of thiol-disulfide homeostasis and IMA levels in chronic hepatitis B patients. In this study we aimed to investigate the changes of thiols-disulfide homeostasis and serum IMA levels in patients with chronic hepatitis B infection compared to the normal population and assesment the benefits in terms of follow-up the patients, medical treatment decision and prognosis.Matherial-Methods: 79 patients diagnosed as chronic HBV infection and 51 healthy controls were included in the study. Demographic data and laboratory results of the patients were recorded. Total thiol, native thiol and disulfide levels were measured by the automated spectrophotometric method described by Erel and Neşelioğlu in serum samples obtained from the patient and healthy control group. SS/SH, SS+SH/SH and SH/SS+SH ratios were calculated from these measured parameters. IMA levels were measured by albumin cobalt binding test.Results: Native thiol and total thiol levels were significantly lower in the patient group (respectively; p=0,0001, p=0,002). There was no statistical significance detected between patient and control groups in terms of disulphide levels (p=0,6). In addition, no statistical significance was detected between the groups in disulfide/native thiol, disulfide/total thiol, native thiol/total thiol ratio. IMA levels were significantly higher in the patient group compared to control group (p=0,0001). Negative significant correlation was detected between IMA and total thiol/native thiol. There was no significant correlation between age, gender, HBV DNA, ALT, biopsy necrosis, fibrosis scores and native thiol, total thiol, disulfide, IMA levels in the patient group in pearson correlation analysis.Conclusions: Total thiols, native thiols and IMA levels were significantly lower in the patient group compared to the control group while no significance was detected in terms of disulphide levels. There was no correlation between viral load, liver necroinflammation and fibrosis grade and these values. Results from this study showed that antioxidant capacity decreases in patients with chronic hepatitis B but these markers are insufficient to determine the degrees of disease severity. Further studies with larger samples need to be carried out. 58

Published
2018

43. Türkiye’deki yoğun bakım ünitelerinde hemşire işgücü yeterli mi? Çok merkezli karia çalışmasının sonuçları

Author

Alpay Ari, Yeşim Kürekçi, Fatmanur Pepe, Handan Alay, Funda Kocak, Mehmet Uçar, Selçuk Özger, Türkkan Öztürk Kaygusuz, Serpil Erol, Rezan Harman, Ramazan Gözüküçük, Güleser Ünsal, Oğuz Reşat Sipahi, Sema Sarı, Ilknur Esen Yildiz, Gül Durmuş, Meliha Meriç Koç, Nefise Oztoprak, Kenan Uğurlu, Aslıhan Demirel, Sevil Alkan Çeviker, Şirin Menekşe, Güven Çelebi, Nilgün Doğan, Ayşe Uyan, Meltem Taşbakan, Firdevs Aksoy, Nurbanu Sezak, Mustafa Doğan, Hilal Sipahi, Pınar Firat, Kevser Ozdemir, Gunes Senol, Sercan Ulusoy, Bilgin Arda, Kübra Demiray, Derya Çağlayan, İrem Akdemir, Sabahat Çağan Aktaş, Ahsen Oncul, Mustafa Arslan, Haluk Erdoğan, Hulya Caskurlu, Özlem Kandemir, Habibe Tülin Elmaslar Mert, Emre Güven, Ege Üniversitesi, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yıldız, İlknur Esen, Zonguldak Bülent Ecevit Üniversitesi, and MERİÇ KOÇ, MELİHA

Subjects
Microbiology (medical), Healthcare associated infections, Infection control, infection, healthcare-associated infections, intensive care infections, health care facilities, manpower, and services, education, lcsh:Medicine, Healthcare-associated infections, lcsh:Infectious and parasitic diseases, Nursing, Infection control practitioner, Intensive care, Medicine, lcsh:RC109-216, Intensive care infections, integumentary system, General Immunology and Microbiology, business.industry, lcsh:R, infection control practitioner, Infectious Diseases, Workforce, Uyan A., Durmus G., Sezak N., Pepe F., Kaygusuz T., Oztoprak N., Ozdemir K., AKSOY F., Erol S., Koc M., et al., -Is Nurse Workforce Sufficient in Intensive Care Units in Turkey. Results of the Multicenter Karia Study-, MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, cilt.6, 2017, business, Infection
Abstract

Introduction: In this multicenter study, we analysed the magnitude of healthcare worker (HCW) [infection control practitioner (ICP), nurses and others] workforce in hospitals participated in the study., Materials and Methods: This study was performed in 41 hospitals (with intensive care units-ICU) located in 22 cities from seven regions of Turkey. We analysed the ICP workforce, nursing and auxiliary HCW (AHCW) workforce in ICUs, number of ICU beds and occupied beds in four different days [two of which were in summer during the vacation time (August 27 and 31, 2016) and two others in autumn (October 12 and 15, 2016)]. The Turkish Ministry of Health (TMOH) requires two patients per nurse in level 3 ICUs, three patients per nurse in level 2 ICUs and five patients per nurse in level 1 ICUs. There is no standardization for the number of AHCW in ICUs. Finally, one ICP per 150 hospital beds is required by TMOH., Results: The total number of ICUs, ICU beds and ICPs were 214, 2377 and 111, respectively in he 41 participated centers. The number ICPs was adequate only in 12 hospitals. The percentage of nurses whose working experience was 2. The number of patients per other HCW was minimum 3.75 and maximum 4.89 on weekdays and on day shift while it was minimum 5.02 and maximum 7.7 on weekends or on night shift. When we compared the number of level 1, 2 and 3 ICUs with adequate nursing workforce vs inadequate nursing workforce, the p value was, Conclusion: Our data suggest that ICP workforce is inadequate in Turkey. Besides, HCW workforce is inadequate and almost 1/4 of nurses are relatively inexperienced especially in level 3 ICUs. Turkish healthcare system should promptly make necessary arrangements for adequate HCW staffing.

Published
2017

44. Epidemiological and molecular characteristics of meticillin-resistant Staphylococcus aureus in Turkey: A multicentre study

Author

Ayşe Willke, Meliha Meric Koc, Celal Ayaz, Akgün Yaman, Murat Sayan, Devrim Dündar, Bülent Sümerkan, Özay Arıkan Akan, Nese Saltoglu, Iftihar Koksal, Çukurova Üniversitesi, and MERİÇ KOÇ, MELİHA

Subjects
0301 basic medicine, Microbiology (medical), Methicillin-Resistant Staphylococcus aureus, Turkey, Epidemiology, 030106 microbiology, Immunology, Erythromycin, MRSA, Biology, medicine.disease_cause, Staphylococcal infections, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Drug Resistance, Multiple, Bacterial, medicine, Immunology and Allergy, Humans, Molecular characteristics, 030212 general & internal medicine, Typing, Cross Infection, SCCmec, Sulfamethoxazole, Clindamycin, biochemical phenomena, metabolism, and nutrition, Staphylococcal Infections, bacterial infections and mycoses, medicine.disease, Methicillin-resistant Staphylococcus aureus, Virology, Trimethoprim, Genes, Bacterial, medicine.drug
Abstract

PubMedID: 27530838 The aim of this study was to investigate the epidemiological and molecular features of clinical meticillin-resistant Staphylococcus aureus (MRSA) isolates in Turkey. MRSA isolates were collected from six regions of Turkey. The mecA and nuc genes were detected by PCR. Antimicrobial susceptibilities were determined by the disk diffusion method. Staphylococcal cassette chromosome mec (SCCmec) and staphylococcal protein A (spa) typing were performed by the sequencing method for 270 randomly selected MRSA isolates. The US Centers for Disease Control and Prevention (CDC) definition was used for epidemiological diagnosis of community-associated MRSA (CA-MRSA). Resistance rates of MRSA to ciprofloxacin, gentamicin, clindamycin, erythromycin, rifampicin, trimethoprim/sulfamethoxazole and tetracycline were 93.4%, 81.2%, 38.5%, 57.8%, 93.9%, 1.1% and 93.1%, respectively. The most frequent SCCmec type was SCCmec III (91.1%). SCCmec type IV was found in 5.2% of the isolates. The most frequent spa type was t030 (81.1%). Five isolates were CA-MRSA if only the epidemiological definition was used (5/725; 0.7%). Two isolates were defined as CA-MRSA both by epidemiological features and SCCmec typing (2/270; 0.7%). Of 14 SCCmec type IV isolates, 12 were not defined as CA-MRSA by epidemiological features. In conclusion, this is the most comprehensive multicentre study in Turkey investigating MRSA using both epidemiological and genotypic features. The CA-MRSA rate is low in Turkey. Combined use of epidemiological and genotypic methods is the most accurate approach for the diagnosis of CA-MRSA. © 2016, Elsevier Ltd. All rights reserved. Firat University Scientific Research Projects Management Unit This work was supported by the Scientific Research Unit of Kocaeli University (Kocaeli, Turkey) [2005/3].

Published
2015

45. Surgical site infection rates in 16 cities in Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)

Author

Ahmet Şahin, Iftihar Koksal, Gaye Usluer, Hülya Sungurtekin, Tanıl Kendirli, Selçuk Kaya, Eylul Gumus, Gürdal Yýlmaz, Mehmet Faruk Geyik, Ertugrul Guclu, Nurettin Erben, Tuna Demirdal, Tuncer Haznedaroglu, Huseyin Turgut, Levent Gorenek, Erdal Ince, Melek Güneş, Hava Yilmaz, Necdet Kuyucu, Suzan Sacar, Alper Şener, Oguz Dursun, Nefise Oztoprak, Ahmet Dilek, Fatma Sirmatel, Ergin Çiftçi, Meliha Meric, Gulsume Kaya, Mustafa Sunbul, Metin Otkun, Emel Azak, Fatma Ülger, Gülden Ersöz, Yunus Gürbüz, Ayşe Willke, Sehnaz Kaya, Hakan Leblebicioglu, Oral Oncul, Davut Ozdemir, Nevin Taşyapar, Ali Acar, Ediz Tutuncu, Zeynep Kaya, Doğaç Uğurcan, Oguz Karabay, Victor D. Rosenthal, Fazilet Duygu, Saban Esen, Ali Kaya, Ata Nevzat Yalcin, Hülya Ulusoy, Gunes Senol, Adem Karbuz, Turan Aslan, Özge Turhan, Selvi Erdogan, Cengiz Uzun, Ilhan Ozgunes, Leblebicioglu, H, Erben, N, Rosenthal, VD, Sener, A, Uzun, C, Senol, G, Ersoz, G, Demirdal, T, Duygu, F, Willke, A, Sirmatel, F, Oztoprak, N, Koksal, I, Oncul, O, Gurbuz, Y, Guclu, E, Turgut, H, Yalcin, AN, Ozdemir, D, Kendirli, T, Aslan, T, Esen, S, Ulger, F, Dilek, A, Yilmaz, H, Sunbul, M, Ozgunes, I, Usluer, G, Otkun, M, Kaya, A, Kuyucu, N, Kaya, Z, Meric, M, Azak, E, Yylmaz, G, Kaya, S, Ulusoy, H, Haznedaroglu, T, Gorenek, L, Acar, A, Tutuncu, E, Karabay, O, Kaya, G, Sacar, S, Sungurtekin, H, Ugurcan, D, Turhan, O, Gumus, E, Dursun, O, Geyik, MF, Sahin, A, Erdogan, S, Ince, E, Karbuz, A, Ciftci, E, Tasyapar, N, Gunes, M, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Güçlü, Ertuğrul, MERİÇ KOÇ, MELİHA, and Ondokuz Mayıs Üniversitesi

Subjects
Turkey, Epidemiology, Surgical wound infection, Health careeassociated infection, Turkey (republic), Cohort Studies, hip prosthesis, Nosocomial infection, Prospective Studies, hospital, Prospective cohort study, Health Policy, craniotomy, clinical trial, cohort analysis, Hospitals, hospital patient, Infectious Diseases, Cohort, Surgical site infection, Cohort study, prospective study, medicine.medical_specialty, Health care-associated infection, prevalence, education, infection rate, surgical infection, Article, Developing countries, coronary artery bypass graft, Internal medicine, medicine, Humans, Hospital infection, human, Cities, cesarean section, business.industry, Public Health, Environmental and Occupational Health, findings of the International Nosocomial Infection Control Consortium (INICC)-, AMERICAN JOURNAL OF INFECTION CONTROL, cilt.43, ss.48-52, 2015 [Leblebicioglu H., Erben N., ROSENTHAL V. D. , ŞENER A., UZUN C., SENOL G., Ersoz G., Demirdal T., DUYGU F., Willke A., et al., -Surgical site infection rates in 16 cities in Turkey], Nosocomial infection control, Confidence interval, shunting, Surgery, Clinical trial, multicenter study, city, business
Abstract

Yalcin, Ata Nevzat/0000-0002-7243-7354; dursun, oguz/0000-0001-5482-3780; Oncul, Oral/0000-0002-1681-1866; Leblebicioglu, Hakan/0000-0002-6033-8543; demirdal, tuna/0000-0002-9046-5666; Ciftci, Ergin/0000-0002-4955-160X; Erben, Nurettin/0000-0003-0373-0132; Kendirli, Tanil/0000-0001-9458-2803; Acar, Ali/0000-0003-2008-5112; Geyik, Mehmet Faruk/0000-0002-0906-0902; Dursun, Oguz/0000-0001-5482-3780; KAYA, ZEYNEP/0000-0002-8468-2103; KARABAY, OGUZ/0000-0003-1514-1685; Karabay, Oguz/0000-0003-0502-432X; Kaya, Sehnaz/0000-0003-0002-1517 WOS: 000347654600011 PubMed: 25564124 Background: Surgical site infections (SSIs) are a threat to patient safety; however, there were no available data on SSI rates stratified by surgical procedure (SP) in Turkey. Methods: Between January 2005 and December 2011, a cohort prospective surveillance study on SSIs was conducted by the International Nosocomial Infection Control Consortium (INICC) in 20 hospitals in 16 Turkish cities. Data from hospitalized patients were registered using the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) methods and definitions for SSIs. Surgical procedures (SPs) were classified into 22 types according to International Classification of Diseases, Ninth Revision criteria. Results: We recorded 1879 SSIs, associated with 41,563 SPs (4.3%; 95% confidence interval, 4.3-4.7). Among the results, the SSI rate per type of SP compared with rates reported by the INICC and CDC NHSN were 11.9% for ventricular shunt (vs 12.9% vs 5.6%); 5.3% for craniotomy (vs 4.4% vs 2.6%); 4.9% for coronary bypass with chest and donor incision (vs 4.5 vs 2.9); 3.5% for hip prosthesis (vs 2.6% vs 1.3%), and 3.0% for cesarean section (vs 0.7% vs 1.8%). Conclusions: In most of the 22 types of SP analyzed, our SSI rates were higher than the CDC NHSN rates and similar to the INICC rates. This study advances the knowledge of SSI epidemiology in Turkey, allowing the implementation of targeted interventions. Copyright (C) 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Published
2015

46. The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study

Author

A. Batirel, H. Erdem, G. Sengoz, F. Pehlivanoglu, E. Ramosaco, S. Gülsün, R. Tekin, B. Mete, İ.İ. Balkan, D.Y. Sevgi, E. Giannitsioti, A. Fragou, S. Kaya, B. Cetin, T. Oktenoglu, A.D. Celik, B. Karaca, E.S. Horasan, M. Ulug, S. Senbayrak, E. Arslanalp, R. Hasbun, S. Ates-Guler, A. Willke, S. Senol, D. Inan, E. Güclü, G.T. Ertem, M.M. Koc, M. Tasbakan, G. Ocal, S. Kocagoz, H. Kusoglu, T. Güven, A.I. Baran, B. Dede, F.Y. Karadag, H. Yilmaz, G. Aslan, D.A. Al-Gallad, S. Cesur, R. El-Sokkary, F. Sirmatel, U. Savasci, G. Karaahmetoglu, H. Vahaboglu, OMÜ, Ege Üniversitesi, MERİÇ KOÇ, MELİHA, Acibadem University Dspace, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Sırmatel, Fatma

Subjects
Adult, Male, Microbiology (medical), medicine.medical_specialty, Adolescent, Endemic Diseases, International Cooperation, Antitubercular Agents, Kyphosis, Gibbus deformity, Scoliosis, Pott disease, Young Adult, Vertebral osteomyelitis, Humans, Medicine, Spondylitis, Aged, Retrospective Studies, Aged, 80 and over, Mediterranean Region, business.industry, Osteomyelitis, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Spondylodiscitis, vertebral osteomyelitis, spondylitis, General Medicine, Middle Aged, medicine.disease, spinal tuberculosis, Survival Analysis, Surgery, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Treatment Outcome, Infectious Diseases, ComputingMethodologies_PATTERNRECOGNITION, Surgical Procedures, Operative, Spinal tuberculosis, Female, Tuberculosis, Spinal, spondylodiscitis, InformationSystems_MISCELLANEOUS, business, Paraplegia
Abstract

PubMed ID: 26232534, We aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection. Although 51% of the patients had multiple levels of vertebral involvement, 8% had noncontiguous involvement of multiple vertebral bodies. The causative agent was identified in 41% of cases. Histopathologic examination was performed in 200 patients (64%), and 74% were consistent with tuberculosis. Medical treatment alone was implemented in 103 patients (33%), while 211 patients (67%) underwent diagnostic and/or therapeutic surgical intervention. Ten percent of the patients required more than one surgical intervention. Mortality occurred in 7 patients (2%), and 77 (25%) developed sequelae. The distribution of the posttreatment sequelae were as follows: 11% kyphosis, 6% Gibbus deformity, 5% scoliosis, 5% paraparesis, 5% paraplegia and 4% loss of sensation. Older age, presence of neurologic deficit and spinal deformity were predictors of unfavourable outcome. ST results in significant morbidity as a result of its insidious course and delayed diagnosis because of diagnostic and therapeutic challenges. ST should be considered in the differential diagnosis of patients with vertebral osteomyelitis, especially in tuberculosis-endemic regions. Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae. © 2015 European Society of Clinical Microbiology and Infectious Diseases.

Published
2015

47. International Nosocomial Infection Control Consortium (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module

Author

Víctor Daniel Rosenthal, Dennis George Maki, Yatin Mehta, Hakan Leblebicioglu, Ziad Ahmed Memish, Haifaa Hassan Al-Mousa, Hanan Balkhy, Bijie Hu, Carlos Alvarez-Moreno, Eduardo Alexandrino Medeiros, Anucha Apisarnthanarak, Lul Raka, Luis E. Cuellar, Altaf Ahmed, Josephine Anne Navoa-Ng, Amani Ali El-Kholy, Souha Sami Kanj, Ider Bat-Erdene, Wieslawa Duszynska, Nguyen Van Truong, Leonardo N. Pazmino, Lucy Chai See-Lum, Rosalia Fernández-Hidalgo, Gabriela Di-Silvestre, Farid Zand, Sona Hlinkova, Vladislav Belskiy, Hussain Al-Rahma, Marco Tulio Luque-Torres, Nesil Bayraktar, Zan Mitrev, Vaidotas Gurskis, Dale Fisher, Ilham Bulos Abu-Khader, Kamal Berechid, Arnaldo Rodríguez-Sánchez, Florin George Horhat, Osiel Requejo-Pino, Nassya Hadjieva, Nejla Ben-Jaballah, Elías García-Mayorca, Luis Kushner-Dávalos, Srdjan Pasic, Luis E. Pedrozo-Ortiz, Eleni Apostolopoulou, Nepomuceno Mejía, May Osman Gamar-Elanbya, Kushlani Jayatilleke, Miriam de Lourdes-Dueñas, Guadalupe Aguirre-Avalos, Diego Marcelo Maurizi, Adriana Montanini, Maria Laura Spadaro, Lorenzo Santiago Marcos, Priscila Botta, Florencia Maria Jerez, Maria Constanza Chavez, Lucia Ramasco, Maria Isabel Colqui, Maria Silvia Olivieri, Ana Silvia Rearte, Gladys Edith Correa, Paola Deolinda Juarez, Paola Fabiana Gallardo, Miriam Patricia Brito, Gabriel Horacio Mendez, Julia Rosa Valdez, Lorena Paola Cardena, Jose Maria Harystoy, Gustavo Jorge Chaparro, Claudia Gabriela Rodriguez, Rodolfo Toomey, Maria Caridi, Monica Viegas, Marisa Liliana Bernan, Adriana Romani, Claudia Beatriz Dominguez, Luis Kushner Davalos, Rosana Richtmann, Camila Almeida Silva, Tatiane T. Rodrigues, Amaury Mielle Filho, Ernandi Dagoberto Seerig Palme, Aline Besen, Caroline Lazzarini, Caroline Batista Cardoso, Francisco Kennedy Azevedo, Ana Paula Fontes Pinheiro, Aparecida Camacho, Braulio Matias De Carvalho, Maria Jose Monteiro De Assis, Ana Paula Vasconcelos Carneiro, Maria Lilian Maciel Canuto, Keyla Harten Pinto Coelho, Tamiris Moreira, Agamenon Alves Oliveira, Marcela Maria Sousa Colares, Marcia Maria De Paula Bessa, Tereza De Jesus Pinheiro Gomes Bandeira, Renata Amaral De Moraes, Danilo Amâncio Campos, Tânia Mara Lima De Barros Araújo, Maria Tereza Freitas Tenório, Simone Amorim, Manuela Amaral, Julianne Da Luz Lima, Lindalva Pino Da Silva Neta, Caphiane Batista, Fabio Jorge De Lima Silva, Maria C. Ferreira De Souza, Katia Arruda Guimaraes, Julia Marcia Maluf Lopes, Karina M. Nogueira Napoles, Lorena Luiza Silva Neto Avelar, Lilian Aguiar Vieira, Luis Gustavo De Oliveira Cardo, Christianne F.V. Takeda, Glaydson A. Ponte, Fco Eduardo Aguiar Leitão, Ricardo De Souza Kuchenbecker, Rodrigo Pires Dos Santos, Erci Maria Onzi Siliprandi, Luiz Fernando Baqueiro Freitas, Ianick Souto Martins, Daiane Casi, Maria Angela Maretti Da Silva, Sergio Blecher, Margarete Villins, Reinaldo Salomao, Solange Regina Oliveira Castro, Daniela V. Da Silva Escudero, Mariana Andrade Oliveira Reis, Marcelo Mendonca, Valter Furlan, Antonio Claudio do Amaral Baruzzi, Tarquino Eristidesg Sanchez, Marina Moreira, Wania Vasconcelos de Freitas, Leonardo Passos de Souza, Velmira Angelova Velinova, Michael M. Petrov, Dimitar Georgiev Karadimov, Emil D. Kostadinov, Violeta Jivkova Dicheva, Chaohua Wang, Xiuqin Guo, Xihua Geng, Shufang Wang, Jinzhi Zhang, Ling Zhu, Shufang Zhuo, Chunli Guo, Tao Lili, Li Ruisheng, Liu Kun, Xuesong Yang, Li Yimin, Mao Pu, Li Changan, Yiang Shumei, Wu Kangxiong, Lin Meiyi, Guxiang Ye, Xu Ziqin, Suo Yao, Song Liqiang, Luis Marino Cañas Giraldo, Elsa Margarita Trujillo Ramirez, Paola Andrea Rios, Juan Carlos Torres Millan, Edwin Giovanny Chapeta Parada, Andres Eduardo Mindiola Rochel, Andres H. Corchuelo Martinez, Ana Marãa Perez Fernandez, Nayide Barahona Guzman, Alfredo Lagares Guzman, Marena Rodriguez Ferrer, Yazmin Leon Vega, Heidi Johanna Munoz, Germán Camacho Moreno, Sandra Liliana Romero Torres, Herlidia Taboada Hernandez, Ismael A. Valderrama MarquezClaudia Linares, Monica Espinosa Valencia, Lusayda Sanchez Corrales, Sandra Milena Bonilla, Jorge Ivan Marin Uribe, David Yepes Gomez, Javier Ospina Martinez, Luz Dary Burgos Florez, Johanna Osorio, Dagoberto Santofimio, Lorena Matta Cortes, Wilmer Villamil-Gomez, Gabriel Munoz Gutierrez, Adela Arguello Ruiz, Carlos Gonzalez Fuentes, Antonio Solano Chinchilla, Ivar Calvo Hernandez, Olber Chavarria Ugalde, Humberto Guanche Garcell, Clara Morales Perez, Selin Bardak, Sumru Ozkan, Nepomuceno Mejia, Adrian M. Puello Guerrero Glenny Mirabal, Margarita Delgado, Ramona Severino, Eliesel Lacerda, Gilda Tolari, María Marcela Bovera, Diego Barahona Pinto, Pedro Fernández González, Gasdali Santacruz, Nelly Alquinga, Celso Zaruma, Nelson Remache, Diego Morocho, Mario Arboleda, Mario Cadena Zapata, Maria Fernanda Garcia, Fabricio Picoita, Jorge Velez, Marcia Valle, Estuardo Salgado Yepez, Diego Morocho Tutillo, Ricardo Arteaga Mora, Andrea Peña Padilla, Mayra Chango, Karina Cabezas, Shirley Tenorio López, Ana Lucía Bonilla Escudero, Gladys Tatiana Sánchez, Hugo Alberto Gonzalez Flores, Islam Abdullorziz Ghazi, Mohamed Hassan, Ghada A. Ismail, Reham Hamed, Mona Mohiedden Abdel-Halim, May Abd El-Fattah, Doaa Abdel-Aziz, Zeinab Salah Seliem, Rasha Hamed Elsherif, Reham Ali Dewdar, Abeer Ahmed Mohmed, Lamiaa Abdel-Fatteh Ahmed, Lilian De Jesus Machuca, Concepcion Bran De Casares, Prokopis Kithreotis, Maria Daganou, Dimitrios Veldekis, Maria Kartsonaki, Achilleas Gikas, Marco Tulio Luque Torres, Denis Padgett, Doris Maribel Rivera, Namita Jaggi, Camilla Rodrigues, Bhagyesh Shah, Keyur Parikh, Jigar Patel, Riya Thakkar, Murali Chakravarthy, B.N. Gokul, R. Sukanya, Leema Pushparaj, Thejas Vini, Sukanya Rangaswamy, Saroj Kumar Patnaik, Vempati Venkateshwar, Biju John, Shamsher Dalal, Suneeta Sahu, Samir Sahu, Banambar Ray, Sudhiranjan Misra, Nisith Mohanty, Biraj Mohan Mishra, Prafulla Sahoo, Naresh Parmar, Sanghamitra Mishra, Basanta Kumar Pati, Santosh Singh, Bhabani Shankar Pati, Aparajita Panda, Swarna Banergee, Dipankar Padhihari, Soumya Samal, Karthikeya Varma, Velu Pandi Suresh Kumar, Ram Gopalakrishnan, Nagarajan Ramakrishnan, Babu Kuruvilla Abraham, Senthilkumar Rajagopal, Ramesh Venkatraman, Ashwin Kumar Mani, Dedeepiya Devaprasad, Lakshmi Ranganathan, Thara Francis, Kotturathu Mammen Cherain, Bala Ramachandran, Ravikumar Krupanandan, S. Muralidharan, Murali Karpagam, Baby Padmini, S. Saranya, Siva Kumar, Nirav Pandya, Rajesh Kakkar, Tenzin Zompa, Narinder Saini, Srinivas Samavedam, Ganshyam Jagathkar, Suhas Nirkhiwale, G.S. Gehlot, Shefali Bhattacharya, Sanjeev Sood, Suman Singh, Sanjeev Singh, Subhash Kumar Todi, Mahuya Bhattacharyya, Arpita Bhakta, Susmita Basu, Anuradha Agarwal, Manoj Agarwal, Mohit Kharbanda, Sankar Sengupta, Anirban Karmakar, Debkishore Gupta, Ajoy Krishna Sarkar, Rimita Dey, Chandramouli Bhattacharya, Mammen Chandy, V.R. Ramanan, Aseem Mahajan, Manas Roy, Sanjay Bhattacharya, Saswati Sinha, Indranil Roy, Umesh Gupta, Sujoy Mukherjee, Mrinmoy Bej, Purnima Mukherjee, Sumana Baidya, Afzal Azim, Asmita Sagar Sakle, Jehangir Soli Sorabjee, Mrunalini Subhash Potdar, Vaibhavi R. Subhedar, F.E. Udwadia, Hena Francis, Arpita Dwivedy, Sheena Binu, Suvin Shetty, Pravin Kumar Nair, Devendra K. Khanna, Felcy Chacko, Seelas Blessymole, Preeti Rajeev Mehta, Tanu Singhal, Sweta Shah, Vatsal Kothari, Reshma Naik, Mayur Harshadrai Patel, Deepesh Gokulchand Aggarwal, Burhanuddin Qutbuddin Jawadwala, Niketa Kaul Pawar, Shoeb Nizamuddin Kardekar, Abizer Nuruddin Manked, S.N. Myatra, J.V. Divatia, R. Kelkar, S.K. Biswas, V. Raut, S. Sampat, Alka Thool, Anil Karlekar, Sumi Nandwani, Sudhir Gupta, Sanjay Singhal, Madhu Gupta, Purva Mathur, Subodh Kumar, Kavita Sandhu, Arnab Dasgupta, Abhijeet Raha, Padmalatha Raman, Ashoo Wadhera, Binesh Badyal, Sarika Juneja, Bikas Mishra, Sunil Sharma, Megha Mehrotra, Jayant Shelgaonkar, Vikram Padbidri, Rohini Dhawale, Sheena Mary Sibin, Dileep Mane, Hanamant Kashinath Sale, Mohammad Mukhit Abdul Gaffar Kazi, Supriya Chabukswar, Anju Mathew, Dipti Gaikwad, Amol Harshe, Gita Nadimpalli, Sunil Bhamare, Soniya Thorat, Omnarayan Sarda, Pattabhiramarao Nadimpalli, Angelina Mendonca, Sujata Malik, Asmita Kamble, Nilakshi Kumari, Sohini Arora, Nita Munshi, Deepa Ganesh Divekar, Maithili Satish Kavathekar, Anuja Kedar Kulkarni, Madhupriya Vijay Suryawanshi, Madhavi Latha Bommala, Anil Bilolikar, Kashmira Limaye Joshi, Charulata Pamnani, Harvinder Wasan, Sonali Khamkar, Leena Steephen, Arjun Rajalakshmi, Anzar Thair, Aisha Mubarak, Swathy Sathish, Suresh Kumar, H. Sunil, Sujith Sujith, null Dinesh, Nagamani Sen, Nitin Shinde, Masoud Alebouyeh, Somayeh Jahani-Sherafat, Mohammad Reza Zali, Mohammad Reza Sarbazi, Nahid Mansouri, Elahe Tajeddin, Maryam Razaghi, Simasadat Seyedjavadi, Marjan Rashidan, Mansoor Masjedi, Behzad Maghsudi, Golnar Sabetian, Anahita Sanaei, Atefeh Yousefipour, Abdullah Mufareh Assiri, Elaine Mari Furukawa-Cinquini, Areej Dhafer Alshehri, Alysia Faye Giani, Nadia Lynette Demaisip, Elizabeth Laungayan Cortez, Analen Fabros Cabato, Jerlie Mae Gonzales Celiz, Ibrahim A.M. Al-Zaydani Asiri, Yassir Khidir Mohammed, Mohammed Abdullah Al Raey, Ali Omer Abdul Aziz, Saeed Ali Al Darani, Misbah Rehman Aziz, Roaa Hasan Basri, Duaa Khalil Al-Awadi, Syed Zahid Bukhari, Rosita Gasmin Aromin, Evangelina Balon Ubalde, Apsia Musa Molano, Hessa Abdullah Al Enizy, Celia Flores Baldonado, Fatima Mohammad Al Adwani, Arlu Marie Casuyon Pahilanga, Avigail M. Tan, Sonia Joseph, Deepa Sasidharan Nair, Nabeela Abdullah Al-Abdullah, Grace Sindayen, Annalyn Amor Malificio, Diaa Abdullah Mohammed, Hanan Mesfer Al Ghamdi, Ameurfina Curioso Silo, Marianina Brenda V. Valisto, Nektarios Foteinakis, Sameeh Salem Ghazal, Mercy V. Joseph, Ahmed Hakawi, Antigona Hasani, Ismet Jusufi, Gazmend Spahija, Nehat Baftiu, Agreta Gecaj-Gashi, Nasser Yehia Aly, Mohammad El-Dossoky Noweir, Suga Thomas Varghese, Ruby Jose Ramapurath, Amna Mostafa Mohamed, Sneha Mary George, Anu Kurian, Amani Fouad Sayed, Mona Foda Salama, Abeer Aly Omar, Flavie Maria Rebello, Dennis Malungcot Narciso, Nada Kara Zahreddine, Zeina Kanafani, Tala Kardas, Bassel Molaeb, Lamia Jurdi, Anwar Al Souheil, Mohamad Ftouni, Hasan Ayash, Tahsine Mahfouz, Tomas Kondratas, Dovile Grinkeviciute, Rimantas Kevalas, Greta Gailiene, Algirdas Dagys, Milena Petrovska, Katja Popovska, Zaneta Bogoevska-Miteva, Katerina Jankovska, Snezana Tufekcievska Guroska, Tanja Anguseva, Wan Nurbayah Wan Yusoff, Anis Shiham Zainal Abidin, Chin Seng Gan, Hasimah Zainol, Vineya Rai, Wong Kang Kwong, Mohd Shahnaz Hasan, Sasheela Sri La Sri Ponnampala, Jeyaganesh Veerakumaran, Ojan Assadian, Doan Mai Phuong, Nguyen Gia Binh, Kerinjeet Kaur, Joelene Lim, Lian-Huat Tan, Jegathesan Manikavasagam, Yuet-Meng Cheong, Hilario Coronado Magaña, Julio Cesar Mijangos Méndez, Federico Corona Jiménez, Sergio Esparza-Ahumada, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Susana Gutierrez-Martinez, Hector Raul Perez-Gomez, Gerardo León-Garnica, Christian Mendoza-Mujica, Martha Cecilia Culebro Burguet, Jorge Horacio Portillo-Gallo, Fernando Aguilera Almazán, Gaspar Iglesias Miramontes, Maria del Rosario Vázquez Olivas, Lucio Alberto Aguilar Angel, Marisol Sanchez Vargas, Angel Orlando Flores Alvarado, Roberto Carlos Mares Morales, Luis Carlos Fernandez Alvarez, Hector Armando Rincon Leon, Karla Reyna Navarro Fuentes, Yuri Mariela Perez Hernandez, Gabriela Martinez Falcon, Angel Gonzalez Vargas, Marco A. Trujillo Juarez, Antonio Martinez Mulia, Paulina Alma Ulloa Camacho, Martha Y. Martinez-Marroquin, Marco Montell Garcia, Araceli Martinez Martinez, Elena Leon Sanchez, Guadalupe Gomez Flores, Marisela del Rocío González Martínez, Jesús Alfonso Galindo Olmeda, Georgina Olivarez, Enrique Barbachano Rodriguez, María Magdalena Gutierrez Castillo, María Guadalupe Villa González, Isaura Beatriz Sauceda Castañeda, Jaime Martínez Rodriguez, Otgon Baatar, Byambadorj Batkhuu, Kabiri Meryem, Barkat Amina, Rédouane Abouqal, Amine Ali Zeggwagh, Tarek Dendane, Khalid Abidi, Naoufel Madani, Syed Faisal Mahmood, Badaruddin A. Memon, Gul Hassan Bhutto, Nadeem Paul, Azra Parveen, Aun Raza, Amjad Mahboob, Summiya Nizamuddin, Faisal Sultan, Hammad Nazeer, Ashraf Ali Khan, Arifa Hafeez, Lydia Lara, Trudell Mapp, Balkys Alvarez, Magda Ivonne Rojas-Bonilla, Elizabeth Castano, Daisy A. De Moros, Roberto Espinoza Atarama, Maria Elena Calisto Pazos, Alfredo Paucar, Marlene Tasayco Ramos, Jenny Jurado, Dafne Moreno, Marãa E. Cruz Saldarriaga, Eliza Ramirez, Carlos Enrique La Hoz Vergara, Walter Enrique Prudencio Leon, Luis Isidro Castillo Bravo, Katya Fernanda Aibar Yaranga, Janet E. Pichilingue Chagray, Vanessa A. Marquez Mondalgo, Socorro Torres Zegarra, Nazario Silva Astete, Francisco Campos Guevara, Javier Soto Pastrana, Carlos F. Linares Calderon, Manuel Jesus Mayorga Espichan, Luis Martin Santivanez Monge, Maria V. Changano Rodriguez, Zoila Rosa Diaz Tavera, Fernando Martin Ramirez Wong, Selene Manga Chavez, Teodora Atencio-Espinoza, Victoria D. Villanueva, Maria Teresa Blanco-Abuy, Arnefelina S. Tamayo, Lailane D. Bergosa, Cristina Mari Jean P. Llames, Marilou F. Trajano, Suzette A. Bunsay, Jessica C. Amor, Regina Berba, Maria Carmen Sg Buenaflor, Ever Labro, Myrna T. Mendoza, Ofelia P. Javellana, Lilibeth G. Salvio, Rhoda Gay Rayco, Vanessa Bermudez, Andrzej Kubler, Marzena Zielinska, Magdalena Kosmider-Zurawska, Barbara Barteczko-Grajek, Ewa Szewczyk, Barbara Dragan, Malgorzata Anna Mikaszewska-Sokolewicz, Tomasz Lazowski, Elsie Cancel, Monica Sorina Licker, Liliana Alina Dragomirescu, Victor Dumitrascu, Dorel Sandesc, Ovidiu Bedreag, Marius Papurica, Delia Muntean, Igor Kotkov, Vladimir Kretov, Vladimir Shalapuda, Alexander Molkov, Sergey Puzanov, Ivan Utkin, Alexander Tchekulaev, Valentina Tulupova, Ljubica Nikolic, Goran Ristic, Jelena Eremija, Jelena Kojovic, Dragana Lekic, Sladjana Vasiljevic, Anna Lesnakova, Alzbeta Marcekova, Katarina Furova, May Osman Gamar Elanbya, Malik Abdo Ali, Shobhana Kumari Kadankunnel, Suwara Somabutr, Rungratchanee Pimathai, Suthinee Wanitanukool, Montri Luxsuwong, Namphon Supa, Pornpheth Prasan, Visanu Thamlikitkul, Silom Jamulitrat, Nonglak Suwalak, Parichart Phainuphong, Bouziri Asma, Borgi Aida, Bel Hadj Sarra, Khaldi Ammar, Gunay Tuncer Ertem, Cemal Bulut, Cigdem Ataman Hatipoglu, Fatma Sebnem Erdinc, Ali Pekcan Demiroz, Menekse Ozcelik, Basak Ceyda Meco, Mehmet Oral, Necmettin Unal, Cigdem Yildirim Guclu, Tanıl Kendirli, Erdal İnce, Ergin Çiftçi, Ayhan Yaman, Çağlar Ödek, Adem Karbuz, Bilge Aldemir Kocabaş, Nilgün Altın, Salih Cesur, Begum Atasay, Omer Erdeve, Hasan Akduman, Dilek Kahvecioglu, Ufuk Cakir, Duran Yildiz, Atila Kilic, Saadet Arsan, Dilek Arman, Serhat Unal, Yasemin Gelebek, Humeyra Zengin, Suha Sen, Hatice Cabadak, Ayse Erbay, Ata Nevzat Yalcin, Ozge Turhan, Melike Cengiz, Oguz Dursun, Perihan Gunasan, Sehnaz Kaya, Atilla Ramazanoglu, Cemal Ustun, Aliye Yasayacak, Hayrettin Akdeniz, Fatma Sirmatel, Ali Metin Otkun, Suzan Sacar, Alper Sener, Huseyn Turgut, Hulya Sungurtekin, Dogaç Ugurcan, Ceyda Necan, Cansu Yilmaz, Davut Ozdemir, Mehmet Faruk Geyik, Nevin Ince, Ayse Danis, Selvi Yener Erdogan, Nurettin Erben, Gaye Usluer, Ilhan Ozgunes, Cengiz Uzun, Oral Oncul, Levent Gorenek, Hakan Erdem, Orhan Baylan, Asu Ozgultekin, Asuman Inan, Sibel Bolukcu, Gunes Senol, Halil Ozdemir, Zeynel Gokmen, Sonay Incesoy Ozdemir, Ali Kaya, Gulden Ersoz, Necdet Kuyucu, Sevim Karacorlu, Zeynep Kaya, Ertugrul Guclu, Gulsume Kaya, Oguz Karabay, Saban Esen, Canan Aygun, Fatma Ulger, Ahmet Dilek, Hava Yilmaz, Mustafa Sunbul, Aynur Engin, Mehmet Bakir, Nazif Elaldi, Iftihar Koksal, Dincer Yildizdas, Ozden Ozgur Horoz, Ayşe Willke, Meliha Meriç Koç, Emel Azak, Naheed Elahi, Philip Annamma, Ashraf El Houfi, Maria Catalina Pirez Garcia, Hector Vidal, Fernando Perez, Gabriel D. Empaire, Yvis Ruiz, Dulce Hernandez, Dayana Aponte, Evelyn Salinas, Claudia Diaz, María Eugenia Guzmán Siritt, Zenaida Durán Gil De Añez, Luis Montes Bravo, Nelva Orozco, Eugenia Mejías, Nguyen Viet Hung, Nguyen Quoc Anh, Ngo Quy Chau, Truong Anh Thu, Le Thi Diem Tuyet, Dang Thi Van Trang, Vo Thi Hong Thoa, Nguyen Phuc Tien, Le Thi Anh Thu, Phan Thi Hang, Tran Thi My Hanh, Tran Thi Thuy Hang, Dinh Pham Phuong Anh, Ondokuz Mayıs Üniversitesi, KILIÇ, ATİLA, and MERİÇ KOÇ, MELİHA

Subjects
Imipenem, medicine.medical_specialty, Pediatrics, Low income countries, Asia, Epidemiology, Klebsiella pneumoniae, Health care-associated infection, Antibiotic resistance, Catheter-associated urinary tract infection, Ceftazidime, Network, Bloodstream infection, Developing countries, Nosocomial infection, Intensive care, medicine, Ventilator-associated pneumonia, Humans, Hospital infection, Prospective Studies, Urinary tract infection, Cross Infection, Infection Control, biology, business.industry, Health Policy, Public Health, Environmental and Occupational Health, medicine.disease, Nosocomial infection control, biology.organism_classification, Device-associated infection, United States, Europe, Pneumonia, Intensive Care Units, Infectious Diseases, Latin America, Amikacin, Emergency medicine, Africa, Limited resources countries, Central line-associated bloodstream infections, Centers for Disease Control and Prevention, U.S, business, medicine.drug
Abstract

Maghsoudi, Behzad/0000-0002-1279-8799; Kritsotakis, Evangelos/0000-0002-9526-3852; Yalcin, Ata Nevzat/0000-0002-7243-7354; Mikaszewska-Sokolewicz, Malgorzata A/0000-0002-1148-7817; ALDEMIR KOCABAS, Bilge/0000-0002-6396-5243; Masjedi, Mohammad Reza/0000-0002-6871-382X; Masjedi, Mansoor/0000-0001-6175-9289; Gan, Chin Seng/0000-0002-6758-4798; Oncul, Oral/0000-0002-1681-1866; Sabetian, Golnar/0000-0001-8764-2150; YAMAN, Ayhan/0000-0002-5651-1286; Ozdemir, Halil/0000-0002-7318-1688; Leon, Hector Armando Rincon/0000-0003-0715-200X; Delia, Muntean/0000-0001-9100-4530; Atasay, Fatma Begum/0000-0002-9114-5293; Zand, Farid/0000-0003-3489-3372; Kuchenbecker, Ricardo/0000-0002-4707-3683; Medeiros, Eduardo A/0000-0002-6205-259X; ROMERO LOPEZ-ALBERCA, CRISTINA/0000-0001-5856-8668; Salomao, Reinaldo/0000-0003-1149-4598; ozdemir, sonay incesoy/0000-0003-2863-901X; Meco, Basak Ceyda/0000-0003-2951-9634; Horoz, Ozden Ozgur/0000-0001-7590-650X; Horhat, Florin George/0000-0001-6133-0204; Kazi, Mohammad Mukhit/0000-0003-3824-5540; Ciftci, Ergin/0000-0002-4955-160X; Abouqal, Redouane/0000-0002-6117-4341; Leblebicioglu, Hakan/0000-0002-6033-8543; Garcell, Humberto Guanche/0000-0001-7279-0062; Kendirli, Tanil/0000-0001-9458-2803; de Souza, Maria Cecilia B V/0000-0003-0318-3087; Sanaei Dashti, Anahita/0000-0002-2827-3575; UNAL, SERHAT/0000-0003-1184-4711; alvarez Moreno, carlos Arturo/0000-0001-5419-4494; Barahona G., Nayide/0000-0003-3559-6900; Rodriguez Ferrer, Marena Luz/0000-0002-8053-8454; Karabay, Oguz/0000-0003-0502-432X; Kaya, Sehnaz/0000-0003-0002-1517; ERDEVE, OMER/0000-0002-3193-0812; Gonzalez Martinez, Marisela del Rocio/0000-0003-1474-736X; Gikas, Achilleas/0000-0002-8455-9631; Baylan, Orhan/0000-0002-6529-7824; Mitrev, Zan/0000-0001-7859-8821; yildizdas, dincer/0000-0003-0739-5108; Ngo, Quy Chau/0000-0002-6787-2757; Duszynska, Wieslawa/0000-0002-5880-4904; KAYA, ZEYNEP/0000-0002-8468-2103; Dragan, Barbara/0000-0003-3108-4211; Gupta, Umesh/0000-0001-7717-1404; Navarro Fuentes, Karla Reyna/0000-0002-6894-8872; zali, Mohammadreza/0000-0002-9027-4560; Morocho Tutillo, Diego Rolando/0000-0002-4974-7856; El Kholy, Amani/0000-0002-0645-7664; Kanj, Souha/0000-0001-6413-3396; Assiri, Abdullah/0000-0002-5605-2876; Unal, Necmettin/0000-0002-9440-7893; Jayatilleke, Kushlani/0000-0002-3931-6630; KARABAY, OGUZ/0000-0003-1514-1685 WOS: 000341307100001 PubMed: 25179325 We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line-associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U. S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN. Copyright (C) 2014 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Published
2014

48. International Nosocomial Infection Control Consortium (INICC) national report on device-associated infection rates in 19 cities of Turkey, data summary for 2003-2012

Author

Leblebicioglu, Hakan, Erben, Nurettin, Rosenthal, Victor Daniel, Atasay, Begum, Erbay, Ayse, Unal, Serhat, Senol, Gunes, Willke, Ayse, Ozgultekin, Asu, Altin, Nilgun, Bakir, Mehmet, Oncul, Oral, Ersoz, Gulden, Ozdemir, Davut, Yalcin, Ata Nevzat, Ozdemir, Halil, Yildizdas, Dincer, Koksal, Iftihar, Aygun, Canan, Sirmatel, Fatma, Sener, Alper, Tuna, Nazan, Akan, OTzay Arikan, Turgut, Huseyin, Demiroz, A. Pekcan, Kendirli, Tanil, Alp, Emine, Uzun, Cengiz, Ulusoy, Sercan, Arman, Dilek, Ozgunes, Ilhan, Usluer, Gaye, Kilic, Atila, Arsan, Saadet, Cabadak, Hatice, Sen, Suha, Gelebek, Yasemin, Zengin, Humeyra, Topeli, Arzu, Alper, Yusuf, Meric, Meliha, Azak, Emel, Inan, Asuman, Turan, Guldem, Haznedaroglu, Tuncer, Gorenek, Levent, Acar, Ali, Cesur, Salih, Engin, Aynur, Kaya, Ali, Kuyucu, Necdet, Geyik, Mehmet Faruk, Aydin, Ozlem Cetinkaya, Erdogan, Nurse Selvi, Turhan, Ozge, Gunay, Nurgul, Gumus, Eylul, Dursun, Oguz, Esen, Saban, Ulger, Fatma, Dilek, Ahmet, Yilmaz, Hava, Sunbul, Mustafa, Gokmen, Zeynel, Ozdemir, Sonay Incesoy, Horoz, Ozden Ozgur, Yylmaz, Gurdal, Kaya, Selcuk, Ulusoy, Hulya, Kucukoduk, Sukru, Ustun, Cemal, Baysal, Abant Izzet, Otkun, Metin, Tulunay, Melek, Oral, Mehmet, Unal, Necmettin, Cengiz, Mustafa, Yilmaz, Leyla, Sacar, Suzan, Sungurtekin, Hulya, Ugurcan, Dogac, Yetkin, M. Arzu, Bulut, Cemal, Erdinc, F. Sebnem, Hatipoglu, Cigdem Ataman, Ince, Erdal, Ciftci, Ergin, Odek, Caglar, Yaman, Ayhan, Karbuz, Adem, Aldemir, Bilge, Kilic, Aysegul Ulu, Arda, Bilgin, Bacakoglu, Feza, Hizel, Kenan, [Leblebicioglu, Hakan -- Esen, Saban -- Ulger, Fatma -- Dilek, Ahmet -- Yilmaz, Hava -- Sunbul, Mustafa] Ondokuz Mayis Univ, Sch Med, Samsun, Turkey -- [Erben, Nurettin -- Ozgunes, Ilhan -- Usluer, Gaye] Eskisehir Osmangazi Univ, Eskisehir, Turkey -- [Rosenthal, Victor Daniel] Int Nosocomial Infect Control Consortium, Ave 4580,Floor 12,Apt D, RA-1195 Buenos Aires, DF, Argentina -- [Atasay, Begum -- Kilic, Atila -- Arsan, Saadet] Ankara Univ, Sch Med, Fac Paediat, Dept Newborn Med, TR-06100 Ankara, Turkey -- [Erbay, Ayse -- Cabadak, Hatice -- Sen, Suha] Turkiye Yuksek Ihtisas Educ & Res Hosp, Ankara, Turkey -- [Unal, Serhat -- Gelebek, Yasemin -- Zengin, Humeyra -- Topeli, Arzu -- Alper, Yusuf] Hacettepe Univ, Sch Med, Ankara, Turkey -- [Senol, Gunes] Suat Seren Chest Dis & Chest Surg Training Hosp, Izmir, Turkey -- [Willke, Ayse -- Meric, Meliha -- Azak, Emel] Kocaeli Univ, Fac Med, Kocaeli, Turkey -- [Ozgultekin, Asu -- Inan, Asuman -- Turan, Guldem] Haydarpasa Numune Training & Res Hosp, Istanbul, Turkey -- [Altin, Nilgun -- Cesur, Salih] Etlik Ihtisas Training & Educ Hosp, Ankara, Turkey -- [Bakir, Mehmet -- Engin, Aynur] Cumhuriyet Univ, Sch Med, Sivas, Turkey -- [Oncul, Oral -- Haznedaroglu, Tuncer -- Gorenek, Levent -- Acar, Ali] Gulhane Mil Med Acad, Haydarpasa Training Hosp, Istanbul, Turkey -- [Ersoz, Gulden -- Kaya, Ali -- Kuyucu, Necdet] Mersin Univ, Fac Med, Mersin, Turkey -- [Ozdemir, Davut -- Geyik, Mehmet Faruk -- Aydin, Ozlem Cetinkaya -- Erdogan, Nurse Selvi] Duzce Univ, Med Sch Infect Dis & Clin Microbiol, Duzce, Turkey -- [Yalcin, Ata Nevzat -- Turhan, Ozge -- Gunay, Nurgul -- Gumus, Eylul -- Dursun, Oguz] Akdeniz Univ, TR-07058 Antalya, Turkey -- [Ozdemir, Halil -- Gokmen, Zeynel -- Ozdemir, Sonay Incesoy] Konya Training & Res Hosp, Konya, Turkey -- [Yildizdas, Dincer -- Horoz, Ozden Ozgur] Cukurova Univ, Balcali Hosp, Adana, Turkey -- [Koksal, Iftihar -- Yylmaz, Gurdal -- Kaya, Selcuk -- Ulusoy, Hulya] Karadeniz Tech Univ, Sch Med, Trabzon, Turkey -- [Aygun, Canan -- Kucukoduk, Sukru] Ondokuz Mayis Univ, Sch Med, Neonatal Unit, Samsun, Turkey -- [Sirmatel, Fatma -- Ustun, Cemal -- Baysal, Abant Izzet] Univ Hosp, Infect Dis & Clin Microbiol, Bolu, Turkey -- [Sener, Alper -- Otkun, Metin] Onsekiz Mart Univ Canakkale, Canakkale, Turkey -- [Tuna, Nazan] Sakarya Univ, Fac Med, Sakarya, Turkey -- [Akan, OTzay Arikan -- Tulunay, Melek -- Oral, Mehmet -- Unal, Necmettin] Ankara Univ, Ibni Sina Hosp, Sch Med, TR-06100 Ankara, Turkey -- [Turgut, Huseyin -- Sacar, Suzan -- Sungurtekin, Hulya -- Ugurcan, Dogac] Pamukkale Univ, Denizli, Turkey -- [Demiroz, A. Pekcan -- Yetkin, M. Arzu -- Bulut, Cemal -- Erdinc, F. Sebnem -- Hatipoglu, Cigdem Ataman] Ankara Numune Training & Res Hosp, Ankara, Turkey -- [Kendirli, Tanil -- Ince, Erdal -- Ciftci, Ergin -- Odek, Caglar -- Yaman, Ayhan -- Karbuz, Adem -- Aldemir, Bilge] Ankara Univ, Sch Med, Dept Paediat Crit Care Med, TR-06100 Ankara, Turkey -- [Alp, Emine -- Kilic, Aysegul Ulu] Erciyes Univ, Fac Med, Kayseri, Turkey -- [Uzun, Cengiz] German Hosp, Istanbul, Turkey -- [Ulusoy, Sercan -- Arda, Bilgin -- Bacakoglu, Feza] Ege Univ, Fac Med, Izmir, Turkey -- [Arman, Dilek -- Hizel, Kenan] Gazi Univ, Sch Med, Ankara, Turkey -- [Cengiz, Mustafa -- Yilmaz, Leyla] Harran Univ, Fac Med, Sanliurfa, Turkey, Ciftci, Ergin -- 0000-0002-4955-160X, Leblebicioglu, Hakan -- 0000-0002-6033-8543, Horoz, Ozden Ozgur -- 0000-0001-7590-650X, Erben, Nurettin -- 0000-0003-0373-0132, Yalcin, Ata Nevzat -- 0000-0002-7243-7354, UNAL, SERHAT -- 0000-0003-1184-4711, MERİÇ KOÇ, MELİHA, Çukurova Üniversitesi, OMÜ, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Sırmatel, Fatma, and Ege Üniversitesi

Subjects
Male, Pediatrics, healthcare associated infection, Turkey, Antibiotic resistance, medicine.medical_treatment, health care facilities, manpower, and services, central venous catheter, Network, intensive care unit, preschool child, Turkey (republic), law.invention, Cohort Studies, Nosocomial infection, law, newborn, device infection, Prevalence, Infection control, Prospective Studies, Prospective cohort study, Child, intensive care, catheter infection, Cross Infection, Urinary tract infection, adult, Ventilator-associated pneumonia, Pneumonia, Ventilator-Associated, General Medicine, cohort analysis, INICC, Intensive care unit, infection control, Device-associated infection, Infectious Diseases, female, Equipment and Supplies, Child, Preschool, disease surveillance, Central venous catheter, devices, Cohort study, prospective study, Microbiology (medical), medicine.medical_specialty, Adolescent, Catheter-associated urinary tract infection, infection rate, Bloodstream infection, Article, critically ill patient, length of stay, Intensive care, medicine, Humans, Hospital infection, human, Healthcare-associated infection, urinary catheter, business.industry, Research, Infant, Newborn, Infant, International Nosocomial Infection Consortium, mechanical ventilator, medicine.disease, Nosocomial infection control, major clinical study, mortality, Catheter-Related Infections, Emergency medicine, ventilator associated pneumonia, Central line-associated bloodstream infections, business
Abstract

WOS: 000346433300001, PubMed ID: 25403704, Background: Device-associated healthcare-acquired infections (DA-HAI) pose a threat to patient safety, particularly in the intensive care unit (ICU). We report the results of the International Infection Control Consortium (INICC) study conducted in Turkey from August 2003 through October 2012. Methods: A DA-HAI surveillance study in 63 adult, paediatric ICUs and neonatal ICUs (NICUs) from 29 hospitals, in 19 cities using the methods and definitions of the U.S. NHSN and INICC methods. Results: We collected prospective data from 94,498 ICU patients for 647,316 bed days. Pooled DA-HAI rates for adult and paediatric ICUs were 11.1 central line-associated bloodstream infections (CLABSIs) per 1000 central line (CL)-days, 21.4 ventilator-associated pneumonias (VAPs) per 1000 mechanical ventilator (MV)-days and 7.5 catheter-associated urinary tract infections (CAUTIs) per 1000 urinary catheter-days. Pooled DA-HAI rates for NICUs were 30 CLABSIs per 1000 CL-days, and 15.8 VAPs per 1000 MV-days. Extra length of stay (LOS) in adult and paediatric ICUs was 19.4 for CLABSI, 8.7 for VAP and 10.1 for CAUTI. Extra LOS in NICUs was 13.1 for patients with CLABSI and 16.2 for patients with VAP. Extra crude mortality was 12% for CLABSI, 19.4% for VAP and 10.5% for CAUTI in ICUs, and 15.4% for CLABSI and 10.5% for VAP in NICUs. Pooled device use (DU) ratios for adult and paediatric ICUs were 0.54 for MV, 0.65 for CL and 0.88 for UC, and 0.12 for MV, and 0.09 for CL in NICUs. The CLABSI rate was 8.5 per 1,000 CL days in the Medical Surgical ICUs included in this study, which is higher than the INICC report rate of 4.9, and more than eight times higher than the NHSN rate of 0.9. Similarly, the VAP and CAUTI rates were higher compared with U. S. NHSN (22.3 vs. 1.1 for VAP; 7.9 vs. 1.2 for CAUTI) and with the INICC report (22.3 vs. 16.5 in VAP; 7.9 vs. 5.3 in CAUTI). Conclusions: DA-HAI rates and DU ratios in our ICUs were higher than those reported in the INICC global report and in the US NHSN report., Foundation to Fight against Nosocomial Infections, The funding for the activities carried out at INICC head quarters were provided by the corresponding author, Victor D. Rosenthal, and Foundation to Fight against Nosocomial Infections.

Published
2014

49. A case of necrotizing fasciitis due to community-acquired methicillin-resistant Staphylococcus aureus Toplum kökenli metisiline dirençli Staphylococcus aureus-un neden olduğu bir nekrotizan fasiit olgusu

Author

Sargın-Altunok, Elif, Meriç, MELİHA, Karahan, Zeynep Ceren, Deniz, Burcu, Ünal, Çiğdem, Willke, Ayşe, and MERİÇ KOÇ, MELİHA

Subjects
Sargın-Altunok E., Meriç M., Karahan Z. C. , Deniz B., Ünal Ç., Willke A., -A case of necrotizing fasciitis due to community-acquired methicillin-resistant Staphylococcus aureus Toplum kökenli metisiline dirençli Staphylococcus aureus-un neden olduğu bir nekrotizan fasiit olgusu-, Klimik Dergisi, cilt.27, ss.26-29, 2014
Published
2014

50. Early Detection of Methicillin Resistance by Real-Time PCR in Staphylococci Isolated from Blood Cultures

Author

Willke, Ayse, SAYAN, MURAT, Meric, MELİHA, MUTLU, BİRSEN, and MERİÇ KOÇ, MELİHA

Subjects
biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) has a significant morbidity and mortality. The aim of this study was to evaluate the efficiency of real-time polymerase chain reaction (Rt-PCR) targeting nuc and mec genes in the culture extracts of blood culture systems for the early diagnosis of MRSA. A total of 48 samples that gave positive growth signal in BACTEC 9000 MB (BD, USA) and stained as gram-positive cocci, were included in the study. The samples were collected between 2009 and 2010. VITEC 2 (bioMerieux, France) system was used for the identification and antibiotic susceptibility testing of the isolates. According to the culture results, 15 of the isolates were methicillin-resistant coagulase-negative staphylococci (MRCNS), four were MRSA, 14 were methicillin-susceptible coagulase-negative staphylococci (MSCNS) and 15 were methicillin-susceptible S.aureus (MSSA). However, Rt-PCR yielded 17 MRCNS, eight MRSA, 10 MSCNS and 13 MSSA results. Our findings indicated lack of concordance between blood culture and PCR technique. When the blood culture results were accepted as the gold standard for the determination of methicillin resistance, sensitivity, specificity, positive and negative predictive values of Rt-PCR were found as 73%, 62%, 56% and 78%, respectively. In conclusion, in contrast to the expectations, Rt-PCR was not considered as an appropriate method for the detection of MRSA in routine diagnosis.

Published
2012

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