Search

Yunqiang Nie,1 Hongjun Liu,2 Xiao Tan,3 Hui Wang,1 Fuzhou Li,4 Cuiyun Li,1 Ping Han,1 Xin Lyv,1 Xinyi Xu,1 Miao Guo5 1Department of Respiratory Medicine, Linyi People’s Hospital, Linyi 276000, China; 2Department of Internal Medicine, 120 Emergency Command Center of Linyi City, Linyi 276002, China; 3Department of Pathology, Linyi People’s Hospital, Linyi 276000, China; 4Department of Radiology, Linyi People’s Hospital, Linyi 276000, China; 5Department of Geriatrics, Linyi People’s Hospital, Linyi 276000, China Background: The aim of this study was to investigate the correlation of EGFR mutation on the high-resolution computed tomography (HRCT) features in lung adenocarcinoma. Patients and methods: A total of 121 patients were diagnosed with lung adenocarcinoma from January 2014 to December 2016. The correlation of indexes (gender, age, tumor diameter, and EGFR mutation) was analyzed based on the HRCT characteristics of lung adenocarcinoma. Results: There were 73 cases of EGFR mutation and 48 cases of wild-type EGFR. One hundred and three cases had pleural indentation that was significant in patients with EGFR mutation than those with wild-type EGFR (P=0.038). Forty-two out of 121 cases exhibited the bronchus cutoff sign. Patients with EGFR mutation were likely to develop the bronchus cutoff sign (P=0.017). Sixty-one out of 121 cases exhibited the lobulation sign, which was significant in patients with EGFR mutation than those with wild-type EGFR (P0.05). Age and gender did not vary significantly in the lobulation sign (P>0.05). Conclusion: HRCT characteristics such as pleural indentation, bronchus cutoff sign, and lobulation sign in lung adenocarcinoma with EGFR mutation were significantly greater than those with wild-type EGFR; however, further study is essential in determining the predictive ability of computed tomography (CT) for EGFR mutations in lung adenocarcinoma. Keywords: computed tomography, EGFR mutation, lung adenocarcinoma, pleural traction, bronchus cutoff sign