13 results on '"Luther, James"'
Search Results
2. Salt sensitivity of blood pressure and aldosterone: interaction between Lysine-specific demethylase 1 gene, sex, and age: Supplemental material
- Author
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Parksook, Wasita, Heydarpour, Mahyar, Gholami, Shadi, Luther, James M., Pojoga, Luminata, Williams, Jonathan, and N. Hopkins, Paul
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bacteria ,complex mixtures - Abstract
Supplemental material for the article "Salt sensitivity of blood pressure and aldosterone: interaction between Lysine-specific demethylase 1 gene, sex, and age"
- Published
- 2022
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- View/download PDF
Catalog
3. Kalhaṇa, Rājataraṅgiṇī
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Luther James Obrock
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- 2022
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4. Autism: Social Communication Disorder
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Scott Luther James Jackson
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- 2021
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5. Early urine electrolyte patterns in patients with acute heart failure
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Collins, Sean P., Jenkins, Cathy A., Baughman, Adrienne, Miller, Karen F., Storrow, Alan B., Han, Jin H., Brown, Nancy J., Liu, Dandan, Luther, James M., McNaughton, Candace D., Self, Wesley H., Peng, Dungeng, Testani, Jeffrey M., and Lindenfeld, JoAnn more...
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Heart Failure ,Male ,Emergency department ,Sodium ,Worsening heart failure ,Acute heart failure ,Pilot Projects ,Stroke Volume ,Middle Aged ,Prognosis ,Original Research Articles ,Acute Disease ,Disease Progression ,Diuretic resistance ,Humans ,Female ,Original Research Article ,Prospective Studies ,Diuretics ,Urine electrolytes ,Biomarkers ,Aged ,Follow-Up Studies - Abstract
Aims We conducted a prospective study of emergency department (ED) patients with acute heart failure (AHF) to determine if worsening HF (WHF) could be predicted based on urinary electrolytes during the first 1–2 h of ED care. Loop diuretics are standard therapy for AHF patients. A subset of patients hospitalized for AHF will develop a blunted natriuretic response to loop diuretics, termed diuretic resistance, which often leads to WHF. Early detection of diuretic resistance could facilitate escalation of therapy and prevention of WHF. Methods and results Patients were eligible if they had an ED AHF diagnosis, had not yet received intravenous diuretics, had a systolic blood pressure > 90 mmHg, and were not on dialysis. Urine electrolytes and urine output were collected at 1, 2, 4, and 6 h after diuretic administration. Worsening HF was defined as clinically persistent or WHF requiring escalation of diuretics or administration of intravenous vasoactives after the ED stay. Of the 61 patients who qualified in this pilot study, there were 10 (16.3%) patients who fulfilled our definition of WHF. At 1 h after diuretic administration, patients who developed WHF were more likely to have low urinary sodium (9.5 vs. 43.0 mmol; P more...
- Published
- 2018
6. Title redacted
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Jackson, Scott Luther James, Dritschel, Barbara, and University of St Andrews
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RC553.A88J2 - Published
- 2016
7. Does Screening with the MDQ and EPDS Improve Identification of Bipolar Disorder in an Obstetrical Sample?
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Clark, Crystal T., Sit, Dorothy K.Y., Driscoll, Kara, Eng, Heather F., Confer, Andrea L., Luther, James F., Wisniewski, Stephen R., and Wisner, Katherine L.
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Adult ,Psychiatric Status Rating Scales ,Depressive Disorder ,Young Adult ,Bipolar Disorder ,Substance-Related Disorders ,Postpartum Period ,Humans ,Female ,Anxiety Disorders ,Article - Abstract
Women with bipolar disorder (BD) are at high risk for postpartum affective episodes and psychosis. Although validated screening tools are available for postpartum unipolar depression, few screening tools for hypomania/mania exist. Screening tools for BD in the postpartum period are essential for improving detection and planning appropriate treatment. We evaluated whether adding the Mood Disorders Questionnaire (MDQ) to the Edinburgh Postnatal Depression Scale (EPDS) increased the identification of BD in the early postpartum period.Women (N = 1,279) who delivered a live infant and screened positive on the EPDS and/or MDQ at 4-6 weeks postbirth were invited to undergo an in-home Structured Clinical Interview for DSM-IV (SCID).Positive EPDS and/or MDQ screens occurred in 12% of the sample (n = 155). In home SCID diagnostic interviews were completed in 93 (60%) of the mothers with positive screens. BD was the primary diagnosis in 37% (n = 34). Women with BD screened positive on the EPDS and/or MDQ as follows: EPDS+/MDQ+ (n = 14), EPDS+/MDQ- (n = 17), and EPDS-/MDQ+ (n = 3). The MDQ identified 50% (17/34) of the women with BD and 6 additional cases of BD when the MDQ question regarding how impaired the mother perceived herself was excluded from the screen criterion.Addition of the MDQ to the EPDS improved the distinction of unipolar depression from bipolar depression at the level of screening in 50% of women with traditional MDQ scoring and by nearly 70% when the MDQ was scored without the impairment criterion. more...
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- 2015
8. Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro
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Tomoyuki Furubayashi, Luther James Willmore, Akitane Mori, Yasuko Noda, Ken-ichi Tanaka, and Takeshi Nanba
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chemistry.chemical_compound ,chemistry ,Liquid chromatography–mass spectrometry ,Radical ,Hydroxyl radical ,Irradiation ,Cleavage (embryo) ,Hydrogen peroxide ,Photochemistry ,Scavenging ,In vitro - Abstract
Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals. more...
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- 2012
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9. Translation and History: The Development of a Kashmiri Textual Tradition from ca. 1000-1500
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Obrock, Luther James
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History ,Kashmir ,Literature ,Sanskrit ,Srivara ,Kalhana ,Historiography ,South Asian studies ,Rajatarangini - Abstract
This dissertation investigates the Sanskrit works of four authors—Somadeva (fl. ca. 1080), Kalhaṇa (fl. ca. 1150), Jonarāja (ca. 1389-1459), and Śrīvara (fl. 1459-1505)—in the Valley of Kashmir. These authors produced a corpus of unique yet interconnected texts, writing in one of two particularly Kashmiri genres—either Kashmiri translational story literature, ślokakathā, or a regional poetic history, [rāja]taraṅgiṇī. The deployment and development of these two genres from the end of the eleventh to the early sixteenth centuries shows the development of a regionalized literature embedded in and adapting to changing social worlds. The first two works set the stage for this discussion. Somadeva’s eleventh-century Kathāsaritsāgara, a same-language translation of the Bṛhatkathā, is exemplary of the ślokakathā genre. It crystalizes a specific set of source critical techniques and attitudes that are necessary for the production of a Kashmiri Sanskrit historiography. Using Somadeva’s insights, Kalhaṇa fashions a new way of writing history in his twelfth century Rājataraṅgiṇī. Three centuries later in the much changed political and cultural landscape of the Kashmiri Sultanate, Jonarāja and Śrīvara continued Kalhaṇa’s historical project in their own (rāja)taraṅgiṇī-s. Finally Śrīvara translated Jāmī’s Persian romance the Yūsuf wa Zulaykhā into a ślokakathā, the Kathākautuka in 1505. To understand this development and the texts’ places in their moments of composition, this dissertation undertakes a series of contextualizations not to look for a homogenous or homogenizing “literary culture” of Sanskrit in Kashmir but rather to trace Somadeva, Kalhaṇa, Jonarāja, and Śrīvara’s creative engagement with Sanskrit texts and genres. This dissertation shifts discussion away from the dominant scholarly idiom of cosmopolitanism to see Sanskrit literary production as deeply imbricated in the changing historical context of second millennium Kashmir. In this way I speak not of Sanskrit as a totalizing literary culture but rather of regionally and historically situated authors shaping new modes of Sanskrit discourse in the world. Sanskrit then, in such an understanding, is not a static form or mode to which authors appeal but a vital voice taking part in the shifting elite spheres from the Lohara Dynasty to the Shāh Mīrī Sultans in Kashmir. more...
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- 2015
10. Mother-Infant Antidepressant Levels, Maternal Depression and Perinatal Events
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Sit, Dorothy, Perel, James M., Wisniewski, Stephen R., Helsel, Joseph C., Luther, James F., and Wisner, Katherine L.
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Article - Published
- 2011
11. Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption
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Martinerie, Laetitia, Viengchareun, Say, Meduri, Géri, Kim, Hyung-Suk, Luther, James, Lombes, Marc, Lombes, Marc, Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Endocrinologie et Maladies de la reproduction, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de génétique moléculaire, pharmacogénétique et hormonologie, Department of Pathology, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), Department of Clincial Pharmacology, Vanderbilt University [Nashville], PremUp Foundation, and Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) more...
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[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,kidney ,aldosterone ,MESH: Gene Expression ,MESH: Humans ,aldosterone-synthase ,MESH: Absorption ,MESH: Aldosterone ,MESH: Kidney ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,MESH: Mice, Knockout ,MESH: Aldosterone Synthase ,MESH: Male ,MESH: Mice, Inbred C57BL ,MESH: Receptors, Aldosterone ,MESH: Receptors, Mineralocorticoid ,MESH: Growth and Development ,MESH: Sodium ,MESH: Animals ,MESH: Mice ,MESH: Female ,Newborns ,mineralocorticoid receptor - Abstract
International audience; Sodium wasting during the neonatal period is the consequence of a physiological aldosterone resistance, related to a low renal mineralocorticoid receptor (MR) expression at birth, both in humans and mice. To investigate whether aldosterone is involved in the neonatal regulation of MR expression, we compared aldosterone and corticosterone levels and renal MR expression by quantitative real-time PCR, between aldosterone synthase (AS) knockout, heterozygous, and wild type (WT) mice, at birth and postnatal d 8. Analysis of MR transcripts showed a similar expression profile in all genotypes, demonstrating that the lack of aldosterone does not modify either the low renal MR expression at birth or its postnatal induction. However, mRNA levels of the α-subunit of the epithelial sodium channel, a MR target gene, were significantly higher in WT compared with AS knockout mice, both at birth and postnatal d 8, despite high corticosterone levels in AS knockout mice, indicating that aldosterone is required for optimal renal induction of the epithelial sodium channel. Using organotypic cultures of newborn WT kidneys, we confirmed that aldosterone does not regulate MR expression at birth, but is instead capable of increasing MR expression in mature kidneys, unlike dexamethasone. In sum, we demonstrate both in vivo and in vitro, that, whereas aldosterone has no significant impact on renal MR expression at birth, it is crucial for optimal MR regulation in postnatal kidneys and for appropriate hydroelectrolytic balance. Understanding of MR-regulatory mechanisms could therefore lead to new therapeutic strategies for the management of sodium loss in preterms and neonates. more...
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- 2011
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12. The problem of fragmented farm holdings in Bavaria, Germany
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Pickrel, Luther James and Agricultural Economics
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Agriculture -- Germany -- Bavaria ,Farms -- Germany -- Bavaria ,LD5655.V855 1952.P53 - Abstract
The field of land reform may involve greater opportunity for land ownership by the cultivator, consolidating small and uneconomic holdings, or the problem of bringing together the many small, widely dispersed plots belonging to the individual farmer so that he can operate efficiently. Although these problems often overlap, it is with the last mentioned phase, or land consolidation, that this study is primarily concerned. Land fragmentation is a condition that exists not only in the area studied, but in many other parts of the world; especially in areas which are referred to in recent terminology as "underdeveloped”, and in areas where the population pressures are great. In the area studied and in adjacent regions people have been aware of the seriousness of this problem for generations. Denmark, for instance, completed the work of consolidating farms and breaking up farm villages more than one hundred years ago. As is pointed out in this study, one region of Bavaria accomplished this task more than four hundred years ago. However, in the remainder of the State and in many other countries progress is painfully slow or does not exist. Yet in most countries, including our own, economic and political stability as well as social progress are closely related to the system of agriculture and the status of the farm population. In many parts of the world failure to recognize this fact and to make the necessary adjustments to overcome inherited evils in these institutional patterns have resulted in economic distress and political unrest. Land consolidation is not proposed as a panacea for all ills nor is it proposed that any one technique in toto can be advantageously applied to all places. On the other hand, the advantages of consolidation, where applicable, should be made available wherever possible to these who are now hindered by the handicaps and limitations forced on them by this heritage. Consolidation should be thought of as a basic part of an overall program of education and better farm management. The problems inherent in the type of agriculture dictated by conditions resulting from the field arrangement pictured in figure l are difficult to envisage, difficult to describe, and difficult to overcome. In the State of Bavaria, approximately 80 percent of all agricultural land (3.15 million hectares) is in more or less the degree of fragmentation indicated in the above picture. The area shown is representative of the typical rural village pattern in the northwestern part of the State. Some progress has been made toward consolidating these scattered holdings and thereby increasing food production, as well as operating efficiency; making possible a better life for the people of the community (figure 2). However the progress has been slow and costly and with present techniques and procedures it is estimated by officials that the job will not be completed in less than sixty-five years. In order to understand this problem more clearly, its implications and effects; as well as to evaluate current attempts at its solution, this study has been made. Master of Science more...
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- 1952
13. Man and Metaphysics
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Luther James, Lee Otis, Beer Samuel, Tillich Paul, Adams George Plimpton, and S van Mierlo
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Philosophy ,Metaphysics ,Epistemology - Published
- 1948
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