10 results on '"Lorrot, M."'
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2. Global Review of the Age Distribution of Rotavirus Disease in Children Aged <5 Years Before the Introduction of Rotavirus Vaccination
- Author
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Hasso-Agopsowicz, Mateusz, Ladva, Nanji, Lopman, Benjamin, Sanderson, Colin, Cohen, Adam, Tate, Jacqueline, Riveros, Ximena, Henao-Restrepo, Ana Maria, Clark, Andrew E., Ladva, Chandresh Nanji, Alkorta, M, Atchison, C, Banajeh, S, Becker-Dreps, S, Benhafid, M, Bhandari, N, Bodhidatta, L, Braeckman, T, Bwogi, J, de Cassia Compagnoli Carmona, R, Cilla, G., Contreras-Roldan, I, Coulson, B, Cunliffe, N, Dagan, R, Givon, N, Degiuseppe, J, Dhiman, S, Dian, Z, Díaz, J., Dutta, S, Krishnan, T, Manna, B, Fletcher-Lartey, S, Fu, C, Gendrel, D., Ghenghesh, K., Gonzalez Mago, G, De Grazia, S, Grimwood, K, Groome, M, Haque, A., Heininger, U, Houpt, E, Iturriza-Gómara, M., Hungerford, D, Jarquin, C, McCracken, J, Contreras, I, Cordon-Rosales, C, Kaiser-Labusch, P, Kang, G, Kar, S, Kiulia, N, Kotloff, K, Latipov, R, Linhares, A, Lorrot, M., Mandile, M, Mast, C, Mathew, M., Matinon-Torres, F, Matthijnssens, J, Mladenova, Z., Monini, M, Montes, M, Arana, A, Motamedifar, M, Najafi, A, Nelson, T., Nokes, J, Ntoumi, F, Numazaki, K, O’Reilly, C, Ochoa, T, Page, N, Page, A., Langendorf, C, Podkolzin, A, Quach, C, Racz, M, de Rougemont, Alexis, Ruiz-Palacios, G, Saha, S, Satter, S, Soares, L, Sudarmo, S, Shigemura, K, Shirakawa, T, Athiyyah, A, Tagbo, B, Tarr, P, Klein, E., Denno, D, Turner, A., Uzoma, E, Vatosoa, R, Wandera, E, Wikswo, M, Payne, D, Yhu-Chering, H, Yoshikawa, T, Sugata, K, Yuan, Q, Liying, L, Zaman, K., Zhou, X -N, Zhang, S -X, Xu, Wei-Jiang, Serhan, Fatima, Nakamura, Tomoka, Antoni, Sébastien, Agócs, Mary, Murray, Jillian, Cherian, Thomas, Mwenda, Jason, Weldegebriel, Goitom, Biey, Joseph, Cheikh, Dah, Teleb, Nadia, Rahman, Hossam Abdel, Ahmed, Hinda, Daniels, Danni, Videbaek, Dovile, Wasley, Annemarie, Singh, Simarjit, de Oliveira, Lucia, Rey-Benito, Gloria, Sanwogou, N Jennifer, Liyanage, Jayantha, Wijesinghe, Pushpa Ranjan, Batmunkh, Nyambat, Grabovac, Varja, Fox, Kimberley, Paladin, Fem Julia, Henschke, Nicholas, Queensland University of Technology [Brisbane] (QUT), Microbiology Service, Hospital Donostia, Grupo de Investigación en Energía y Medioambiente [Bucaramanga]] (GIEMA), Universidad Industrial de Santander [Bucaramanga] (UIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Tripoli - University Al Fateh, Visva Bharati University, Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, Department of Virology, National Reference Laboratory of Enteroviruses, National Center of Infectious and Parasitic Diseases [Sofia, Bulgarie] (NCIPD), Friction Stir Laboratory, Brigham Young University (BYU), UFR des Sciences de Santé (Université de Bourgogne), Université de Bourgogne (UB), Centre National de Référence des virus entériques [CHU de Dijon] (CNR virus entériques), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire de sérologie-virologie (CHU de Dijon), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), School of Social and Community Medicine [Bristol], University of Bristol [Bristol], Vaccine Preventable Disease and Immunization, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), and University of Stavanger
- Subjects
rotavirus gastroenteritis ,age distribution ,rotavirus ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,vaccine ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology - Abstract
International audience; We sought datasets with granular age distributions of rotavirus-positive disease presentations among children
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- 2019
- Full Text
- View/download PDF
3. The worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: developing hospital-quality indicators of antibiotic prescribing for children
- Author
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Versporten A1, Bielicki J2, Drapier N1, Sharland M2, Goossens H3, ARPEC project group. Calle GM, Garrahan JP, Clark J, Cooper C, Blyth CC, Francis JR, Alsalman J, Jansens H, Mahieu L, Van Rossom P, Vandewal W, Lepage P, Blumental S, Briquet C, Robbrecht D, Maton P, Gabriels P, Rubic Z, Kovacevic T, Nielsen JP, Petersen JR, Poorisrisak P, Jensen LH, Laan M, Tamm E, Matsinen M, Rummukainen ML, Gajdos V, Olivier R, Le Maréchal F, Martinot A, Dubos F, Lagrée M, Prot-Labarthe S, Lorrot M, Orbach D, Pagava K, Hufnagel M, Knuf M, Schlag SA, Liese J, Renner L, Enimil A, Awunyo M, Syridou G, Spyridis N, Critselis E, Kouni S, Mougkou K, Ladomenou F, Gkentzi D, Iosifidis E, Roilides E, Sahu S, Murki S, Malviya M, Kalavalapalli DB, Singh S, Singhal T, Garg G, Garg P, Kler N, Soltani J, Jafarpour Z, Pouladfar G, Nicolini G, Montagnani C, Galli L, Esposito S, Tenconi R, Lo Vecchio A, Dona' D, Giaquinto C, Borgia E, D'Argenio P, De Luca M, Centenari C, Raka L, Raka D, Omar A, Al-Mousa H, Mozgis D, Sviestina I, Burokiene S, Usonis V, Tavchioska G, Hargadon-Lowe A, Zarb P, Borg MA, González Lozano CA, Zárate Castañon P, Cancino ME, McCullagh B, McCorry A, Gormley C, Al Maskari Z, Al-Jardani A, Pluta M, Rodrigues F, Brett A, Esteves I, Marques L, Ali AlAjmi J, Claudia Cambrea S, Rashed AN, Mubarak Al Azmi AA, Chan SM, Isa MS, Najdenov P, Čižman M, Unuk S, Finlayson H, Dramowski A, Maté-Cano I, Soto B, Calvo C, Santiago B, Saavedra-Lozano J, Bustinza A, Escosa-García L, Ureta N, Lopez-Varela E, Rojo P, Tagarro A, Barrero PT, Rincon-Lopez EM, Abubakar I, Aston J, Heginbothom M, Satodia P, Garbash M, Johnson A, Sharpe D, Barton C, Menson E, Arenas-Lopez S, Luck S, Doerholt K, McMaster P, Caldwell NA, Lunn A, Drysdale SB, Howe R, Scorrer T, Gahleitner F, Gupta R, Nash C, Alexander J, Raman M, Bell E, Rajagopal V, Kohlhoff S, Cox E, Zaoutis T., Mahieu, Ludo, ARPEC Project Grp, ARPEC project group, Versporten, A1, Bielicki, J2, Drapier, N1, Sharland, M2, Goossens, H3, ARPEC project group., Calle GM, Garrahan, Jp, Clark, J, Cooper, C, Blyth, Cc, Francis, Jr, Alsalman, J, Jansens, H, Mahieu, L, Van Rossom, P, Vandewal, W, Lepage, P, Blumental, S, Briquet, C, Robbrecht, D, Maton, P, Gabriels, P, Rubic, Z, Kovacevic, T, Nielsen, Jp, Petersen, Jr, Poorisrisak, P, Jensen, Lh, Laan, M, Tamm, E, Matsinen, M, Rummukainen, Ml, Gajdos, V, Olivier, R, Le Maréchal, F, Martinot, A, Dubos, F, Lagrée, M, Prot-Labarthe, S, Lorrot, M, Orbach, D, Pagava, K, Hufnagel, M, Knuf, M, Schlag, Sa, Liese, J, Renner, L, Enimil, A, Awunyo, M, Syridou, G, Spyridis, N, Critselis, E, Kouni, S, Mougkou, K, Ladomenou, F, Gkentzi, D, Iosifidis, E, Roilides, E, Sahu, S, Murki, S, Malviya, M, Kalavalapalli, Db, Singh, S, Singhal, T, Garg, G, Garg, P, Kler, N, Soltani, J, Jafarpour, Z, Pouladfar, G, Nicolini, G, Montagnani, C, Galli, L, Esposito, S, Tenconi, R, Lo Vecchio, A, Dona', D, Giaquinto, C, Borgia, E, D'Argenio, P, De Luca, M, Centenari, C, Raka, L, Raka, D, Omar, A, Al-Mousa, H, Mozgis, D, Sviestina, I, Burokiene, S, Usonis, V, Tavchioska, G, Hargadon-Lowe, A, Zarb, P, Borg, Ma, González Lozano, Ca, Zárate Castañon, P, Cancino, Me, Mccullagh, B, Mccorry, A, Gormley, C, Al Maskari, Z, Al-Jardani, A, Pluta, M, Rodrigues, F, Brett, A, Esteves, I, Marques, L, Ali AlAjmi, J, Claudia Cambrea, S, Rashed, An, Mubarak Al Azmi, Aa, Chan, Sm, Isa, M, Najdenov, P, Čižman, M, Unuk, S, Finlayson, H, Dramowski, A, Maté-Cano, I, Soto, B, Calvo, C, Santiago, B, Saavedra-Lozano, J, Bustinza, A, Escosa-García, L, Ureta, N, Lopez-Varela, E, Rojo, P, Tagarro, A, Barrero, Pt, Rincon-Lopez, Em, Abubakar, I, Aston, J, Heginbothom, M, Satodia, P, Garbash, M, Johnson, A, Sharpe, D, Barton, C, Menson, E, Arenas-Lopez, S, Luck, S, Doerholt, K, Mcmaster, P, Caldwell, Na, Lunn, A, Drysdale, Sb, Howe, R, Scorrer, T, Gahleitner, F, Gupta, R, Nash, C, Alexander, J, Raman, M, Bell, E, Rajagopal, V, Kohlhoff, S, Cox, E, and Zaoutis, T.
- Subjects
0301 basic medicine ,Male ,Pediatrics ,Latin Americans ,Cross-sectional study ,Prevalence ,Psychological intervention ,Drug resistance ,Global Health ,infectious diseases ,0302 clinical medicine ,Global health ,Medicine ,030212 general & internal medicine ,Child ,antibiotics, children ,Drugs -- Prescribing ,Pharmacology. Therapy ,Hospitals -- Europe ,Drug Resistance, Microbial ,Hospitals ,Anti-Bacterial Agents ,Europe ,Child, Preschool ,Anti-infective agents ,Female ,medicine.drug ,Microbiology (medical) ,medicine.medical_specialty ,Cefepime ,030106 microbiology ,Drug Prescriptions ,03 medical and health sciences ,Surgical prophylaxis ,pharmacology ,pharmacology (medical) ,Environmental health ,Humans ,Biology ,Quality Indicators, Health Care ,business.industry ,Health status indicators -- Europe ,Infant ,Drug Utilization ,Cross-Sectional Studies ,Health Care Surveys ,Human medicine ,business - Abstract
Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children., peer-reviewed
- Published
- 2018
4. Variation in paediatric hospital antibiotic guidelines in Europe
- Author
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Spyridis, N., Syridou, G., Goossens, H., Versporten, A., Kopsidas, J., Kourlaba, G., Bielicki, J., Drapier, N., Zaoutis, T., Tsolia, M., Sharland, M., Vergison, A., Leon, V., Delestrait, M., Huza, C., Lepage, P., Mahieu, L., Boy, T., Jansens, H., Van Der Linden, D., Briquet, C., Allegaert, K., Smits, A., Gabriels, P., Vuye, A., Lutsar, I., Tamm, E., Larionova, A., Laan, D., Orbach, M., Lorrot, M., Angoulvant, F., Prot-Labarthe, S., Dubos, F., Lagree, M., Hufnagel, M., Schuster, K., Henneke, P., Roilides, E., Iosifidis, E., Corovessi, V., Michos, A., Galanakis, E., Gkentzi, D., Giacquinto, C., Longo, G., Dona', D., Mion, T., D'Argenio, P., Degli, M. L. C., De Luca, M., Ciliento, G., Esposito, S., Danieli, E., Montinaro, V., Tenconi, R., Nicolini, G., Sviestina, C. I. M., Pavare, J., Rasnaca, K., Gardovska, D., Usonis, V., Grope, I., Gurksniene, V., Eidukaite, A., Biver, A., Brett, A., Esteves, I., Cambrea, S. C., Craiu, M., Tomescu, E., Cizman, M., Babnik, J., Kenda, R., Vidmar, I., Nunez-Cuadros, E., Rojo, P., Lopez-Varela, E., Ureta, N., Perez-Lopez, A., Mosqueda, R., Orta, L., Santos, M., Navarro, M., Santiago, B., Hernandez-Sampelaya, T., Saavedra, J., Pineiro, R., Torel, P., Cano, I. M., Baumann, P., Berger, C., Menson, E., Botgros, A., Doerholt, K., Drysdale, S., Makwana, N., Mccorry, A., Garbash, E. M., Chetcutiganado, C., Mcleod, M., Caldwell, N., Nash, C., Mccullagh, B., Sharpe, D., Tweddell, L., Liese, J. G., Aston, J., Gallagher, A., Satodia, P., Howard-Smith, N., Korinteli, I., Tavchioska, G., Jensen, L., Trethon, A., Unuk, S., Childs, N., Canlas, J., Mahieu, Ludo, and ARPEC Project Grp
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Pediatrics ,practice guidelines as topic ,Antibiotics ,cross-sectional studies ,respiratory tract infections ,sepsis ,0302 clinical medicine ,newborn ,Medicine ,030212 general & internal medicine ,Practice Patterns, Physicians' ,humans ,European paediatric hospitals ,antibiotic guidelines ,childhood infection ,anti-bacterial agents ,bacterial infections ,child ,preschool ,drug administration schedule ,drug prescriptions ,Europe ,hospitals ,pediatric ,infant ,practice patterns ,physicians' ,urinary tract infections ,pediatrics ,perinatology and child health ,Antistaphylococcal penicillins ,Respiratory tract infections ,Neonatal sepsis ,Hospitals, Pediatric ,Child, Preschool ,medicine.drug ,medicine.medical_specialty ,medicine.drug_class ,Sepsis ,03 medical and health sciences ,030225 pediatrics ,Internal medicine ,business.industry ,Infant, Newborn ,Guideline ,Amoxicillin ,medicine.disease ,Penicillin ,Pediatrics, Perinatology and Child Health ,Human medicine ,business - Abstract
ObjectiveTo assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics.DesignParticipating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empirical antibiotic treatment including duration of therapy for 5 common infection syndromes: respiratory tract, urinary tract, skin and soft tissue, osteoarticular and sepsis in neonates and children.Results84 hospitals from 19 European countries participated in the survey of which 74 confirmed the existence of guidelines. Complete guidelines (existing guidelines for all requested infection syndromes) were reported by 20% of hospitals and the majority (71%) used a range of different sources. Guidelines most commonly available were those for urinary tract infection (UTI) (74%), neonatal sepsis (71%) and sepsis in children (65%). Penicillin and amoxicillin were the antibiotics most commonly recommended for respiratory tract infections (RTIs) (up to 76%), cephalosporin for UTI (up to 50%) and for skin and soft tissue infection (SSTI) and bone infection (20% and 30%, respectively). Antistaphylococcal penicillins were recommended for SSTIs and bone infections in 43% and 36%, respectively. Recommendations for neonatal sepsis included 20 different antibiotic combinations. Duration of therapy guidelines was mostly available for RTI and UTI (82%). A third of hospitals with guidelines for sepsis provided recommendations for length of therapy.ConclusionsComprehensive antibiotic guideline recommendations are generally lacking from European paediatric hospitals. We documented multiple antibiotics and combinations for most infections. Considerable improvement in the quality of guidelines and their evidence base is required, linking empirical therapy to resistance rates.
- Published
- 2015
- Full Text
- View/download PDF
5. The worldwide antibiotic resistance and prescribing in european children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children
- Author
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Versporten, A. Bielicki, J. Drapier, N. Sharland, M. Goossens, H. Calle, G.M. Clark, J. Cooper, C. Blyth, C.C. Francis, J.R. Alsalman, J. Jansens, H. Mahieu, L. Van Rossom, P. Vandewal, W. Lepage, P. Blumental, S. Briquet, C. Robbrecht, D. Maton, P. Gabriels, P. Rubic, Z. Kovacevic, T. Nielsen, J.P. Petersen, J.R. Poorisrisak, P. Jensen, L.H. Laan, M. Tamm, E. Matsinen, M. Rummukainen, M.-L. Gajdos, V. Olivier, R. Le Maréchal, F. Martinot, A. Prot-Labarthe, S. Lorrot, M. Orbach, D. Pagava, K. Hufnagel, M. Knuf, M. Schlag, S.A.A. Liese, J. Renner, L. Enimil, A. Awunyo, M. Syridou, G. Spyridis, N. Critselis, E. Kouni, S. Mougkou, K. Ladomenou, F. Gkentzi, D. Iosifidis, E. Roilides, E. Sahu, S. Murki, S. Malviya, M. Kalavalapalli, D.B. Singh, S. Singhal, T. Garg, G. Garg, P. Kler, N. Soltani, J. Jafarpour, Z. Pouladfar, G. Nicolini, G. Montagnani, C. Galli, L. Esposito, S. Vecchio, A.L. Dona', D. Giaquinto, C. Borgia, E. D'Argenio, P. De Luca, M. Centenari, C. Raka, L. Omar, A. Al-Mousa, H. Mozgis, D. Sviestina, I. Burokiene, S. Usonis, V. Tavchioska, G. Hargadon-Lowe, A. Zarb, P. Borg, M.A. González Lozano, C.A. Castañon, P.Z. Cancino, M.E. McCullagh, B. McCorry, A. Gormley, C. Al Maskari, Z. Al-Jardani, A. Pluta, M. Rodrigues, F. Brett, A. Esteves, I. Marques, L. AlAjmi, J.A. Cambrea, S.C. Rashed, A.N. Al Azmi, A.A.M. Chan, S.M. Isa, M.S. Najdenov, P. Čižman, M. Unuk, S. Finlayson, H. Dramowski, A. Maté-Cano, I. Soto, B. Calvo, C. Santiago, B. Saavedra-Lozano, J. Bustinza, A. Escosa-García, L. Ureta, N. Tagarro, A. Barrero, P.T. Rincon-Lopez, E.M. Abubakar, I. Aston, J. Heginbothom, M. Satodia, P. Garbash, M. Johnson, A. Sharpe, D. Barton, C. Menson, E. Arenas-Lopez, S. Luck, S. Doerholt, K. McMaster, P. Caldwell, N.A. Lunn, A. Drysdale, S.B. Howe, R. Scorrer, T. Gahleitner, F. Gupta, R. Nash, C. Alexander, J. Raman, M. Bell, E. Rajagopal, V. Kohlhoff, S. Cox, E. Zaoutis, T. ARPEC project group
- Abstract
Objectives: Previously, web-based tools for cross-sectional antimicrobial point prevalence surveys (PPSs) have been used in adults to develop indicators of quality improvement. We aimed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children worldwide. Methods: A standardized antimicrobial PPS method was employed. Included were all inpatient children and neonates receiving an antimicrobial at 8:00 am on the day of the PPS. Denominators included the total number of inpatients. A web-based application was used for data entry, validation and reporting. We analysed 2012 data from 226 hospitals (H) in 41 countries (C) from Europe (174H; 24C), Africa (6H; 4C), Asia (25H; 8C), Australia (6H), Latin America (11H; 3C) and North America (4H). Results: Of 17 693 admissions, 6499 (36.7%) inpatients received at least one antimicrobial, but this varied considerably between wards and regions. Potential indicators included very high broad-spectrum antibiotic prescribing in children of mainly ceftriaxone (ranked first in Eastern Europe, 31.3%; Asia, 13.0%; Southern Europe, 9.8%), cefepime (ranked third in North America, 7.8%) and meropenem (ranked first in Latin America, 13.1%). The survey identified worryingly high use of critically important antibiotics for hospital-acquired infections in neonates (34.9%; range from 14.2% in Africa to 68.0% in Latin America) compared with children (28.3%; range from 14.5% in Africa to 48.9% in Latin America). Parenteral administration was very common among children in Asia (88%), Latin America (81%) and Europe (67%). Documentation of the reasons for antibiotic prescribing was lowest in Latin America (52%). Prolonged surgical prophylaxis rates ranged from 78% (Europe) to 84% (Latin America). Conclusions: Simple web-based PPS tools provide a feasible method to identify areas for improvement of antibiotic use, to set benchmarks and to monitor future interventions in hospitalized neonates and children. To our knowledge, this study has derived the first global quality indicators for antibiotic use in hospitalized neonates and children. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
- Published
- 2016
6. Variation in paediatric hospital antibiotic guidelines in Europe
- Author
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Spyridis, N. Syridou, G. Goossens, H. Versporten, A. Kopsidas, J. Kourlaba, G. Bielicki, J. Drapier, N. Zaoutis, T. Tsolia, M. Sharland, M. Vergison, A. Léon, V. Delestrait, M. Huza, C. Lepage, P. Mahieu, L. Boy, T. Jansens, H. Van Der Linden, D. Briquet, C. Allegaert, K. Smits, A. Gabriels, P. Vuye, A. Lutsar, I. Tamm, E. Larionova, A. Laan, D. Orbach, M. Lorrot, M. Angoulvant, F. Prot-Labarthe, S. Dubos, F. Lagree, M. Hufnagel, M. Schuster, K. Henneke, P. Roilides, E. Iosifidis, E. Corovessi, V. Michos, A. Galanakis, E. Gkentzi, D. Giacquinto, C. Longo, G. Dona, D. Mion, T. D'Argenio, P. Degli, M.L.C. De Luca, M. Ciliento, G. Esposito, S. Danieli, E. Montinaro, V. Tenconi, R. Nicolini, G. Sviestina, C.I.M. Pavare, J. Rasnaca, K. Gardovska, D. Usonis, V. Grope, I. Gurksniene, V. Eidukaite, A. Biver, A. Brett, A. Esteves, I. Cambrea, S.C. Craiu, M. Tomescu, E. Cizman, M. Babnik, J. Kenda, R. Vidmar, I. Nunez-Cuadros, E. Rojo, P. Lopez-Varela, E. Ureta, N. Perez-Lopez, A. Mosqueda, R. Orta, L. Santos, M. Navarro, M. Santiago, B. Hernandez-Sampelaya, T. Saavedra, J. Pineiro, R. Torel, P. Cano, I.M. Baumann, P. Berger, C. Menson, E. Botgros, A. Doerholt, K. Drysdale, S. Makwana, N. McCorry, A. Garbash, E.M. Chetcutiganado, C. McLeod, M. Caldwell, N. Nash, C. McCullagh, B. Sharpe, D. Tweddell, L. Liese, J.G. Aston, J. Gallagher, A. Satodia, P. Howard-Smith, N. Korinteli, I. Tavchioska, G. Jensen, L. Trethon, A. Unuk, S. Childs, N. Canlas, J.
- Abstract
Objective: To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. Design: Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empirical antibiotic treatment including duration of therapy for 5 common infection syndromes: respiratory tract, urinary tract, skin and soft tissue, osteoarticular and sepsis in neonates and children. Results: 84 hospitals from 19 European countries participated in the survey of which 74 confirmed the existence of guidelines. Complete guidelines (existing guidelines for all requested infection syndromes) were reported by 20% of hospitals and the majority (71%) used a range of different sources. Guidelines most commonly available were those for urinary tract infection (UTI) (74%), neonatal sepsis (71%) and sepsis in children (65%). Penicillin and amoxicillin were the antibiotics most commonly recommended for respiratory tract infections (RTIs) (up to 76%), cephalosporin for UTI (up to 50%) and for skin and soft tissue infection (SSTI) and bone infection (20% and 30%, respectively). Antistaphylococcal penicillins were recommended for SSTIs and bone infections in 43% and 36%, respectively. Recommendations for neonatal sepsis included 20 different antibiotic combinations. Duration of therapy guidelines was mostly available for RTI and UTI (82%). A third of hospitals with guidelines for sepsis provided recommendations for length of therapy. Conclusions: Comprehensive antibiotic guideline recommendations are generally lacking from European paediatric hospitals. We documented multiple antibiotics and combinations for most infections. Considerable improvement in the quality of guidelines and their evidence base is required, linking empirical therapy to resistance rates.
- Published
- 2016
7. The antibiotic resistance and prescribing in European Children project: a neonatal and pediatric antimicrobial web-based point prevalence survey in 73 hospitals worldwide
- Author
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Versporten, A, Sharland, M, Bielicki, J, Drapier, N, Vankerckhoven, V, Goossens, H, ARPEC Project Group Members, Cooper, C, Lee, Ly, Whitehouse, J, Bryant, Pa, Haeusler, G, Curtis, N, Starr, M, Vergison, A, Léon, V, Delestrait, M, Huza, C, Lepage, P, Mahieu, L, Boiy, T, Jansens, H, Van der Linden, D, Briquet, C, Allegaert, K, Smits, A, Lutsar, I, Tamm, E, Larionova, A, Orbach, D, Lorrot, M, Angoulvant, F, Doit, C, Prot-Labarthe, S, Dubos, F, Lagree, M, Biscardi, S, Decobert, F, Hau, I, Madhi, F, Durrmeyer, X, Bojang, K, Abubakr, I, Okomo, U, Awe, R, Anderson, S, Akwara, I, Ideh, Rc, Pagava, K, Hufnagel, M, Schuster, K, Henneke, P, Enimil, A, Osei-Akoto, A, Nguah, Sb, Ansong, D, Iosifidis, E, Roilides, E, Spyridis, N, Syridou, G, Soltani, J, Soleimani, N, Nahedi, S, Khosravi, F, Pouladfar, G, Jafarpour, Z, Giacquinto, C, Longo, G, Donà, D, Mion, T, D'Argenio, P, Ciofi Degli Atti ML, De Luca, M, Ciliento, G, Esposito, S, Danieli, E, Montinaro, V, Tenconi, R, Centenari, C, Nicolini, G, Mozgis, D, Sviestina, I, Pavare, J, Rasnaca, K, Gardovska, D, Grope, I, Usonis, V, Gurksniene, V, Eidukaite, A, Biver, A, Bennett, A, O'Hare, B, Kennedy, N, Brett, A, Rodrigues, F, Esteves, I, Cambrea, Sc, Craiu, M, Tomescu, E, Al Shehri MA, Al Shahrani, D, Cizman, M, Babnik, J, Kenda, R, Vidmar, I, Finlayson, H, Rabie, H, Cotton, M, Dramowski, A, Rodrigo, C, Mendez, M, Rojo, P, López-Varela, E, Ureta, N, Mosqueda, R, Pérez-López, A, Orta, L, Santos, M, Navarro, M, Santiago, B, Hernández-Sampelayo, T, Saavedra, J, Bustinza, A, Gil, J, Valls, A, Santesteban, E, Baumann, P, Berger, C, Gifford, A, Menson, E, Botgros, A, Arenas-Lopez, S, Wade, P, Doerholt, K, Drysdale, Sb, Mcelnay, Jc, Kearney, Mp, Scott, Mg, Magee, Fa, Aldeyab, M, Heginbothom, M, Newland, Jg, Hedican, Eb, Shah, H, Stach, L, and Yu, D
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Microbiology (medical) ,Pediatrics ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,MEDLINE ,Drug resistance ,Drug Prescriptions ,point prevalence survey ,antibiotic use ,Antibiotic resistance ,Intensive care ,Drug Resistance, Bacterial ,Medicine ,Humans ,Child ,Electronic Data Processing ,Internet ,business.industry ,Health services research ,Antimicrobial ,antimicrobial use ,Confidence interval ,Drug Utilization ,Hospitals ,Anti-Bacterial Agents ,Europe ,Infectious Diseases ,Pediatrics, Perinatology and Child Health ,surveillance ,hospitalized children ,Health Services Research ,business ,Public Health Administration - Abstract
Background The neonatal and pediatric antimicrobial point prevalence survey (PPS) of the Antibiotic Resistance and Prescribing in European Children project (http://www.arpecproject.eu/) aims to standardize a method for surveillance of antimicrobial use in children and neonates admitted to the hospital within Europe. This article describes the audit criteria used and reports overall country-specific proportions of antimicrobial use. An analytical review presents methodologies on antimicrobial use. Methods A 1-day PPS on antimicrobial use in hospitalized children was organized in September 2011, using a previously validated and standardized method. The survey included all inpatient pediatric and neonatal beds and identified all children receiving an antimicrobial treatment on the day of survey. Mandatory data were age, gender, (birth) weight, underlying diagnosis, antimicrobial agent, dose and indication for treatment. Data were entered through a web-based system for data-entry and reporting, based on the WebPPS program developed for the European Surveillance of Antimicrobial Consumption project. Results There were 2760 and 1565 pediatric versus 1154 and 589 neonatal inpatients reported among 50 European (n = 14 countries) and 23 non-European hospitals (n = 9 countries), respectively. Overall, antibiotic pediatric and neonatal use was significantly higher in non-European (43.8%; 95% confidence interval [CI]: 41.3-46.3% and 39.4%; 95% CI: 35.5-43.4%) compared with that in European hospitals (35.4; 95% CI: 33.6-37.2% and 21.8%; 95% CI: 19.4-24.2%). Proportions of antibiotic use were highest in hematology/oncology wards (61.3%; 95% CI: 56.2-66.4%) and pediatric intensive care units (55.8%; 95% CI: 50.3-61.3%). Conclusions An Antibiotic Resistance and Prescribing in European Children standardized web-based method for a 1-day PPS was successfully developed and conducted in 73 hospitals worldwide. It offers a simple, feasible and sustainable way of data collection that can be used globally.
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- 2013
8. [Update in vaccinations]
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Alain , S., Aubert , M., Aumaitre , H., Beytout , J., Pretet , Jean-Luc, Bloch , K., Bouhour , D., Callamand , P., Caulin , P., Chave , C., Cheymol , J., Denis , F., Derrough , T., Prétet , Jean-Luc, Dodet , B., Duclos , A., Dunais , B., Gagneur , A., Gaillat , J., Gillet , Y., Gras-Le-Guen , C., Hanslik , T., Hau-Rainsard , I., Lorrot , M., Malvy , D., Marchou , B., Minodier , P., Mory , O., Paccalin , M., Parez , N., Perpoint , T., Picherot , G., Pinquier , D., Regnier , F., Roblot , P., Rogeaux , O., Sana , C., Savagner , C., Stephan , Jl, Strady , C., Soubeyrand , B., Weil-Olivier , C., Teaching hospital, Étude et compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sanofi Pasteur MSD, Etude et compréhension de la biodiversité ( ECODIV ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), SANOFI Recherche, and Viala, Pascale
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MESH: Vaccines ,Vaccines ,MESH: Humans ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,MESH : Vaccination ,MESH : Humans ,Vaccination ,Humans ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,MESH: Vaccination ,MESH : Vaccines ,ComputingMilieux_MISCELLANEOUS ,[ SDV.CAN ] Life Sciences [q-bio]/Cancer - Abstract
International audience
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- 2009
9. [Osteoarticular infections: therapeutic proposals of the Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP)]
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Grimprel, E., Lorrot, M., Haas, H., Pinquier, D., Parez, N., Ferroni, A., Cohen, R., CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Département de Pédiatrie, Hôpital Saint Vincent de Paul, Université Pierre et Marie Curie - Paris 6 (UPMC), Association Clinique et Thérapeutique du Val-de-Marne (ACTIV), ACTIV, Service de microbiologie, and CHI Créteil
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Methicillin-Resistant Staphylococcus aureus ,Staphylococcus aureus ,Neisseriaceae Infections ,Administration, Oral ,Kingella kingae ,Penicillins ,Amoxicillin-Potassium Clavulanate Combination ,Pneumococcal Infections ,Drug Resistance, Bacterial ,Humans ,Child ,Pristinamycin ,Cross Infection ,Bacteria ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Infant ,Bacterial Infections ,Staphylococcal Infections ,Bone Diseases, Infectious ,Anti-Bacterial Agents ,Community-Acquired Infections ,Treatment Outcome ,Methicillin Resistance ,Joint Diseases ,Rifampin ,Fluoroquinolones - Abstract
International audience; The empiric choice of initial antibiotherapy in osteoarticular infections in infants and children must take into consideration the actual epidemiology of principal pathogens, their respective antibiotic sensitivity profile, their pharmacokinetic and pharmacodynamic properties and the results of efficacy clinical studies. After a review of recent data concerning these four major points, the Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP) has proposed guidelines for initial recommended schemes of antimicrobial therapy in acute and non complicated osteoarticular infections in infants and children.
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- 2008
- Full Text
- View/download PDF
10. Detection of rabbit rotavirus by polymerase chain reaction in faeces and comparison of gene 9 sequence between two isolated strains
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Ceré, Nicolas, Niepceron, Alisson, Vasseur, M., Lorrot, M., Vautherot, Jean-François, Licois, Dominique, Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration
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[SDV] Life Sciences [q-bio] ,health care facilities, manpower, and services ,[SDV]Life Sciences [q-bio] ,education ,ComputingMilieux_MISCELLANEOUS ,health care economics and organizations - Abstract
Congrès publié en 3 volumes. Vol.B, chapitre : Pathology and Prophylaxis; International audience
- Published
- 2000
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