Search

Your search keyword '"Lisitsyn NA"' showing total 1 results
Start Over Author "Lisitsyn NA" Database OpenAIRE
1 results on '"Lisitsyn NA"'

1. Mutation to rifampicin resistance at the beginning of the RNA polymerase beta subunit gene in Escherichia coli

Author

E. P. Moiseyeva, Eugene D. Sverdlov, Vadim Nikiforov, Lisitsyn Na, and O. N. Danilevskaya

Subjects
Sequence analysis, Macromolecular Substances, Biology, medicine.disease_cause, chemistry.chemical_compound, Plasmid, RNA polymerase, polycyclic compounds, Genetics, medicine, Escherichia coli, Transversion, Molecular Biology, Gene, Base Sequence, Drug Resistance, Microbial, DNA-Directed RNA Polymerases, rpoB, Molecular biology, chemistry, Genes, Genes, Bacterial, Mutation, Rifampin, Rifampicin, medicine.drug
Abstract

The unusual recombinant plasmid pRC19 carrying the N-terminal fragment of the Escherichia coli RNA polymerase rpoB gene was found to specify high level rifampicin resistance of E. coli cells. Sequence analysis of this plasmid revealed one substitution only: transversion G----T, leading to amino acid substitution Val146----Phe. This mutational change marks the second domain of the beta subunit involved in rifampicin binding.

Published
1984

Catalog

Books, media, physical & digital resources
See catalog results