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Australian fashion is emblematic of Global North countries with high levels of consumption and waste, dominated by high street fast fashion brands. It also has some unique characteristics as it is located in the Asia-Pacific region – the central production hub of garments – and is a leading producer of quality natural fibres such as cotton and wool. Despite this, Australia has a hollowed-out manufacturing sector that can provide minimal value add to these fibres, and little reuse, remanufacturing or recycling infrastructure for post-consumption garment waste. Ambition for change in the Australian fashion sector is rapidly accelerating with product stewardship initiatives, a modern slavery act and textile waste being designated a priority by the Commonwealth government. Both the policy and industry landscape is evolving. This article reflects on the research landscape of Australian sustainable fashion. The authors of this article draw on multi- and interdisciplinary perspectives and the UN Sustainable Development Goals (SDGs) to survey and consider the trajectory of fashion sustainability research in Australia over the past decade and to identify key strengths and gaps. This survey culminates in the development of a research agenda for the next decade to 2030.

A 30-membered library of amides based on the potent urotensin II (UII) receptor agonist FL104, has been synthesized from ten different carboxylic acids and three amines. A synthetic protocol producing the amides in 47-98% yield has been developed in which the purification involved only extractions and in a few cases filtration through an ion-exchange resin. It was found that 5mg of starting material was enough to obtain reproducible results and excellent purities. Thus, the procedure is estimated to be transferable to fully automated systems. The synthesized compounds were evaluated for their UII receptor agonistic activities using a cell-based assay (R-SAT). The most active compounds were the 4-trifluoromethylcinnamic amides of 1-(4-chlorophenyl)-3-dimethylamino-propylamine and 1-(2-naphthyl)-3-dimethylamino-propylamine, both showed EC(50) values of 130 nM.