Author: "Lila" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

11,615 results on '"Lila"'

1. Population variation in seabird non-breeding season ecology: implications for vulnerability assessments

Author: Buckingham, Lila
Abstract: For animals that breed in temperate and polar regions, the highest levels of mortality typically occur during the non-breeding season, driven by harsh environmental conditions that increase energy expenditure and reduce food availability. Despite this crucial link with mortality, our understanding of non-breeding season distribution, behaviour, diet and energetics remains poor. Seabird populations have declined rapidly over the past century and are vulnerable to multiple marine threats. Offshore wind farms (OWFs) are an emerging threat that can impact seabirds via collision and displacement, with implications for survival and productivity. Despite the importance of understanding population-level vulnerability to OWFs, current non-breeding season assessments use observational data that are not linked to breeding colony. Broadening our understanding of population variation in exposure to and potential impact severity of OWFs is key to improving our assessment of seabird vulnerability at the population and meta-population levels. The aims of this thesis were to investigate the non-breeding season ecology of common guillemots Uria aalge and razorbills Alca torda and their vulnerability to displacement effects from OWFs. Using data collected from birds that bred at twelve colonies in the UK, I investigated species- and population-level differences in non-breeding season distribution, diet, behaviour and energy expenditure, and combined these data to assess the vulnerability of each species to displacement effects. Firstly, I used geolocation-immersion loggers to map distributions of guillemots and razorbills from each breeding colony during two key periods of the non-breeding season (post-breeding moult and mid-winter) and investigated the level of population aggregation in each species. Secondly, using dual-deployed geolocators and time-depth recorders on guillemots from four colonies, I investigated colony-level variation in monthly distribution, foraging behaviour, activity budgets and energy expenditure throughout the non-breeding season and used stable isotope analysis to infer relative trophic level during the post-breeding moult. Finally, I calculated spatial density and energetic extraction of all adult breeding birds within our tracked range throughout the non-breeding season. I found higher levels of population aggregation in razorbills than guillemots, particularly during mid-winter. Razorbills are therefore less likely to interact with OWFs than guillemots, but the impact of any overlap may be more severe at the meta-population level. Although guillemots displayed colony-level variation in distribution, diet and behaviour, they had remarkably similar energy expenditure across colonies. Energy expenditure peaked in late winter, indicating that displacement effects may have a more severe impact at this time. I identified the waters off the north-east coast of Scotland as an area of vulnerability to displacement effects in both species, as there was overlap between areas of high density and energy extraction with potential OWFs. The findings of this thesis have expanded our understanding of population variation in non-breeding season seabird ecology and have direct applications to marine spatial planning, particularly with regards to development of OWFs in UK waters.
Published: 2025
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2. Potensi Trichoderma asperellum TKD dalam Menghambat Phytophthora spp. pada Benih Kakao Selama Masa Penyimpanan

Author: Kadek Dian Lila Sawitri Kumala Lila, null Meitini Wahyuni Proborini, and null Febri Eka Wijayanti
Subjects: General Economics, Econometrics and Finance
Abstract: Benih berkualitas sangat diperlukan dalam perbanyakan tanaman kakao. Adanya infeksi Phytophthora spp. menjadikan kualitas benih kakao menurun yang berdampak pada kemampuan tumbuh tanaman. Cendawan T. asperellum TKD dapat menghambat pertumbuhan patogen. Tujuan penelitian ini yaitu menguji kemampuan T. asperellum TKD dalam menghambat Phytophthora spp. secara in vitro dan in vivo, menentukan konsentrasi spora T. asperellum TKD yang optimum dan uji viabilitas benih. Perlakuan in vitro dilakukan dengan kultur ganda, dan perlakuan in vivo dilakukan pada benih kakao. Parameter yang diamati meliputi persentase daya hambat dengan kultur ganda, daya kecambah, indeks kecepatan perkecambahan dan penurunan populasi Phytophtora spp. Hasil penelitian menunjukan T. asperellum TKD menghambat Phytophthora spp. secara in vitro dan in vivo (P≤0,05). Rerata daya hambat in vitro adalah 58,74±4,58%. Konsentrasi spora T. asperellum TKD hingga 104 efektif menurunkan populasi Phytophthora spp secara in vivo. Konsentrasi spora T. asperellum TKD yang dapat menghambat pertumbuhan Phytophthora spp. yang optimum adalah konsentrasi T1,70x106. Mekanisme penghambat T. asperellum TKD adalah kompetisi dimana terjadi interaksi dengan mekanisme mikoparasit dan antibiosis. Pemberian T. asperellum TKD menyebabkan benih memiliki daya perkecambahan lebih dari 80% dengan diikuti indeks kecepatan kecambah yang tinggi. Pemberian T. asperellum TKD mampu menghambat pertumbuhan Phytophthora spp. secara in vitro dan in vivo dan benih kakao dapat berkecambah optimal hingga hari ke-7 penyimpanan setelah pemberian T. asperellum TKD.
Published: 2023
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3. Citizen science needs a name change

Author: Elizabeth R. Ellwood, Gregory B. Pauly, June Ahn, Kate Golembiewski, Lila M. Higgins, Miguel A. Ordeñana, and Matt von Konrat
Subjects: Ecology, Evolution, Behavior and Systematics
Published: 2023
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4. Comparison Adoption Application Music Playlist Joox, Spotify, & YouTube Music Using Diffusion Technology Theory

Author: Lila Setiyani, Shiddieq Fathurrozaq, and Dudi Awalludin
Abstract: Application playlist music start lots favored by people in Indonesia. There are several playlist music presented in the Play Store and the App Store. Among them Joox, Spotify, YouTube Music, and more lots again. This is interesting for we find out which one is the most suitable and popular in society. Objective study is to know comparison of Playlist Music applications among them Joox, Spotify, and YouTube Music among society. Diffusion Technology Theory was chosen as the framework for evaluating the reception of 3 apps. The procedure study started with collecting data based on variables from Diffusion Technology Theory. Collected data processed with the use of Application smart pls. Research results This shows variable influencing variables _ reception Joox Music Playlist application, Spotify and YouTube Music, among others Profit Relative (RA) effect to Activity Listen Music (Y), Compatibility (CT) matters to Activity Listen Music (Y), Complexity (CX) matters to Activity Listen Music (Y), Triability (TR) effect to Activity Listen to Music (Y), Observability (OB) influence to Activity Listen to Music (Y). Research results this can be used by providers of Playlist Music apps to develop possible features, liked by fans Music Playlists application.
Published: 2023
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5. Dynamic Capability for Digital Transformation in Family-Owned Company: A Systematic Review

Author: Lila Maria Kaban and Martinus Tukiran
Subjects: Microbiology (medical), Immunology, Immunology and Allergy
Abstract: Dynamic capability has been used as the basis for organizations to build digital transformation to stay competitive in the market. This literature review aims to determine the significance of dynamic capability and digital transformation in family businesses. Using a systematic literature review methodology and utilizing the Dimensions database, three articles that met the criteria and fulfilled the goal of the review were selected. The findings indicate that family businesses have important dynamic capabilities that can aid their survival and expansion through digital transformation. Therefore, family business owners and managers should be able to identify and effectively use their dynamic capabilities to implement digital transformation in their business operations. Keywords: Digital Transformation, Dynamic Capability, Entrepreneurship, Family Business, Innovation
Published: 2023
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6. Response of Nitrogen and Foliar Application of Boron on Growth and Yield of Barley (Hordeum vulgare L.)

Author: Lila Ram Chandrawanshi and Rajesh Singh
Subjects: Materials Chemistry
Abstract: The field experiment entitled “Response of Nitrogen and Foliar Application of Boron on Growth and Yield of Barley (Hordeum vulgare L.)” was conducted Response of during the rabi season of 2022 in Crop Research Farm, Department of Agronomy, Naini Agricultural Institute, SHUATS, Prayagraj (U.P.). The experiment was laid out in a Randomized Block Design with ten treatment combinations. The soil in the experimental area was sandy loam with pH (7.6), EC (0.305 d S/m), organic carbon (0.23%), available N (184.8 kg/ha), available P (16.45 kg/ha) and available K (187.64 kg/ha). Seeds are sown at a spacing of 23 cm × 5 cm to a seed rate of 100 kg/ha. Consisting of three nitrogen levels (45, 60 and 75 kg N/ha) on different Concentration of Boron viz., 1, 1.5 and 3% foliar spray. The experimental result reveals that growth parameters viz., plant height (102 cm), number of tillers/running row meter (95.66), plant dry weight (19.08 g) and Yield attributes viz., No. of effective tillers/m2 (200.33), number of grains/spike (52.60), seed yield (4.81 t/ha) and straw yield (6.48 t/ha) recorded to be significantly higher with treatment 9 (75 kg N/ha + 3% Boron).
Published: 2023
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7. PENINGKATAN HASIL BELAJAR SISWA PADA MATA PELAJARAN PPKN DENGAN MODEL PEMBELAJARAN DISCOVERY LEARNING DI SMP NEGERI 1 MERAPI BARAT

Author: LILA HAYATI
Abstract: The purpose of this classroom action research is a.) to improve the learning process carried out in class. b.) to improve teacher performance. c.) to improve student learning outcomes in Civics subjects with the Discovery Learning Learning Model in class VIII.A SMP Negeri 1 Merapi Barat. This study used Classroom Action Research in two cycles. Each cycle consists of four stages, namely: design, activity and observation, reflection, and revision. This research took the subject of class VIII.A SMP Negeri 1 West Merapi as many as 30 students. The results showed that student learning outcomes in Civics subjects with the Discovery Learning Learning Model had increased and the data obtained was in the form of end-of-cycle test results, observation sheets of teaching and learning activities. From the results of the analysis, it was found that the increase in student scores could be seen in cycle I, which obtained a mastery learning score (30.00%) at the first meeting and (46.67%) in the second meeting with an average score of 66.16 and the highest score was 85 and the lowest was 50. And in the second cycle the learning completeness score increased to (70.00%) at the first meeting, and increased to 28 students or (93.33%) at the second meeting with an average score of 80.66 and the highest score was 95 and the lowest was 65 The conclusion from this study is that learning with the Discovery Learning Model can improve student learning outcomes in class VIII.A SMP Negeri 1 Merapi Barat and this learning model can be used as an alternative to Civics learning. ABSTRAKTujuan penelitian tindakan kelas ini adalah a.) untuk meningkatkan proses pembelajaran yang dilakukan di kelas. b.) untuk meningkatkan kinerja guru. c.) untuk meningkatkan hasil belajar siswa pada mata pelajaran PPKn dengan Model Pembelajaran Discovery Learning di kelas VIII.A SMP Negeri 1 Merapi Barat. Penelitian ini menggunakan Penelitian Tindakan Kelas (Classroom Action Research) sebanyak dua siklus. Setiap siklus terdiri dari empat tahap yaitu: rancangan, kegiatan dan pengamatan, refleksi, dan refisi. Penelitan ini mengambil subjek siswa kelas VIII.A SMP Negeri 1 Merapi Barat sebanyak 30 siswa. Hasil penelitian menunjukkan bahwa hasil belajar siswa pada mata pelajaran PPKn dengan Model Pembelajaran Discovery Learning mengalami peningkatan dan data yang diperoleh berupa hasil tes akhir siklus, lembar observasi kegiatan belajar mengajar. Dari hasil analis didapatkan peningkatan nilai siswa dapat dilihat pada siklus I diperoleh nilai ketuntasan belajar (30,00%) pada pertemuan pertama dan (46,67%) pertemuan kedua dengan nilai rata-rata 66,16 dan nilai tertinggi 85 dan terendah 50. Dan pada siklus ke II nilai ketuntasan belajar meningkat menjadi (70,00%) pada pertemuan pertama, dan meningkat menjadi 28 siswa atau (93,33%) pada pertemuan kedua dengan nilai rata-rata 80,66 dan nilai tertinggi 95 dan terendah 65. Kesimpulan dari penelitian ini adalah dengan pembelajaran dengan Model Discovery Learning dapat meningkatkan hasil belajar siswa pada kelas VIII.A SMP Negeri 1 Merapi Barat serta model pembelajaran ini dapat digunakan sebagai salah satu alternatif pembelajaran PPKn.
Published: 2023
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8. Microwave-assisted extraction optimization and conventional extraction of phenolic compounds from coriander leaves: UHPLC characterization and antioxidant activity

Author: Khokha Mouhoubi, Lila Boulekbache-Makhlouf, Khodir Madani, Mohamed Lamine Freidja, Artur M.S. Silva, and Susana M. Cardoso
Subjects: General Engineering
Abstract: Background: Qualitative and quantitative investigations of bioactive compounds in plant materials are heavily based on the selection of an accurate extraction method. Aims: That’s why; this work consists of a comparative study between Microwave Assisted Extraction (MAE) and Conventional Extraction (CE), based on the total phenolic compounds (TPC) yield, phenolic profile, and antioxidant activity of coriander leaves powder (Coriandrum sativum L.). Material and Methods: MAE was optimized and performed using the Response Surface Methodology (RSM), and was modeled by using a second-order regression equation. While CE was done using the classic water bath method. Results: Under the optimal conditions, the recovery of TPC yield obtained was 37.94 ± 2.06 mg (MAE) vs 44.47 ± 0.57 mg GAE/g DW (CE). The UHPLC characterization showed a close phenolic composition of the two extracts, mainly represented by quercetin glucosides and by dimethoxycinnamoyl hexoside. No significant difference (p>0.05) was recorded in terms of the antioxidant activity of both extracts, as estimated by Ferric reducing antioxidant power (FRAP), Nitric oxide (NO•), and superoxide anion (O2•-) scavenging tests. Conclusions: Hence, the exploitation of MAE has many valuable advantages, as the processing time is brief and the antioxidant activities and phenolic composition were not affected by the extraction process.
Published: 2023
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9. Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY)

Author: Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Abdelaziz, Mohamed Abdelfattah, Bushra Abdelqader, Audrey Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Ajibode Abdulakeem, Rezan Abdul-Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andres Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron-Thomas, Debbie Affleck, Carmel Afnan, Muhammad Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Laura Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana G Ahmed, Syed Ahmed, Syed H Ahmed, Roa Ahmed Ali, Bilal Ahmed Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, Christine Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al-Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John Alexander, Peter D G Alexander, Julyan Al-fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al-Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed Ali, Mohammad Ali, Muhammad S Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ali, Emilio Aliberti, Jade Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Abdullah Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal F T Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al-Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al-Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Amel Amelia Ganefianty, Katharine Ames, Maria R Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, James Amoah-Dankwa, Victoria Amosun, Muhammad Amsal, Khaled Amsha, John Amuasi, Noelia Amutio Martin, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, Laura Anderson, Marina Anderson, Michelle Anderson, Nicola Anderson, Rachel Anderson, Rebecca Anderson, Rory Anderson, Samantha Anderson, Wendy Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Joyann Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Louise Anning, Maldwyn Ansah, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Varghese Anu, Muhammad Anwar, Elena Apetri, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia F Aquino, Bianca Araba, Samuel Aransiola, Mariana Araujo, Ann Archer, Denise Archer, Samuel Archer, Simon Archer, Daniele Arcoria, Christian Ardley, Ana-Maria Arias, Oluwatoyin Aribike, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Jennifer Armistead, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Wendy Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Andrew Arnott, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Armena Arumaithurai, Ayush Arya, Rita Arya, Diptesh Aryal, Denisa Asandei, Adeeba Asghar, Malik Asghar, Arif Ashab, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Georgia Asher, Zakariya Ashfak, Ayesha Ashfaq, Abdul Ashish, Dawn Ashley, Sally Ashman-Flavell, Sundar Ashok, Abd-El-Aziz Ashour, Muhammad Z Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Fiona J Ashworth, Rebecca Ashworth, Arshia Aslam, I Aslam, Suhail Aslam, Laura Aslett, Harshini Asogan, Atif Asrar, Omar Assaf, Raine Astin-Chamberlain, Deborah Athorne, Billie Atkins, Christopher Atkins, Stacey Atkins, John Atkinson, Vicki Atkinson, Abolaji Atomode, Brygitta Atraskiewicz, Abdul A Attia, Eva Attubato, Marie Attwood, Paula Aubrey, Zoltan Auer, Avinash Aujayeb, Aye Chan Thar Aung, Hnin Aung, Hnin Wint Wint Aung, Ko Ko Aung, Kyaw Thu Aung, Nwe Aung, Yin Aung, Zaw Myo Aung, Emily Austin, Karen Austin, Abdusshakur Auwal, Malcolm Avari, Miriam Avery, Nicholas Aveyard, Joanne Avis, Georgina Aviss, Cristina Avram, Paula Avram, Abuzar Awadelkareem, Gabriel Awadzi, Mahmoud Awaly, Atia Awan, Aszad Aya, Eman Ayaz, John Maximilian Ayerh, Amanda Ayers, Jawwad Azam, Ahmed Azeem, Mohammed Azharuddin, Ammar Aziz, Ghazala Aziz, Imran Aziz, N Aziz, Ali Azkoul, Ashaari Azman Shah, Giada Azzopardi, Hocine Azzoug, Fiyinfoluwa Babatunde, Melvin Babi, Babiker Babiker, Gayna Babington, Matthew Babirecki, Marta Babores, Adetona O Babs-Osibodu, Sammy Bacciarelli, Roudi Bachar, Michel-Elie Bachour, Alisjahbana Bachti, Gina Bacon, Jenny Bacon, Bibi Badal, Aysha Badat, Maryuma Bader, Gurpreet R Badhan, Shreya Badhrinarayanan, Joseph P Bae, Alice Baggaley, Amy Baggott, Graham Bagley, Dinesh Bagmane, Lynsey Bagshaw, Kasra Bahadori, Angela Bailey, James Bailey, Katie Bailey, Lindsey Bailey, Liz Bailey, Lucy Bailey, Maria A Bailey, Morgan Bailey, Pippa Bailey, Sarah Bailey, Hamish Baillie, J Kenneth Baillie, Jennifer Bain, Vikram Bains, David Baird, Eilidh Baird, Kevin Baird, Susan Baird, Tracy Baird, Yolanda Baird, Aiysha Bajandouh, Danielle C Baker, Evelyn Baker, Johanne Baker, Josephine Baker, Kenneth Baker, Mark Baker, Rebecca Baker, Terri-Anne Baker, Victoria Baker, Hugh Bakere, Nawar Bakerly, Michelle Baker-Moffatt, Ameet Bakhai, Nauman Bakhtiar, Panos Bakoulas, Dhanalakshmi Bakthavatsalam, Niranjan Balachandran, Andrea Balan, Prasath Balasingam, Theodosios Balaskas, Madhu Balasubramaniam, Nicola Balatoni, Alison Balcombe, Alexander Baldwin, Ashley Baldwin, Caron Baldwin, Danielle Baldwin, Fiona Baldwin, Rebekah Baldwin-Jones, Nichola Bale, James Balfour, Matthew Ball, Robert Ball, K Ballard, Ismael Balluz, Craig Balmforth, Emese Balogh, Abeir Baltmr, Amir Baluwala, Gabby Bambridge, Alasdair Bamford, Amy Bamford, Peter Bamford, Adefunke Bamgboye, Elizabeth Bancroft, Hollie Bancroft, Joyce Banda, Krishna Bandaru, Srini Bandi, Nageswar Bandla, Somaditya Bandyopadhyam, Amit Banerjee, Ritwik Banerjee, Santosh Baniya, Omar Bani-Saad, Harrison Banks, Luke Banks, Paul Banks, Claudia Bann, Helen Bannister, Oliver Bannister, Laura Banton, Tran Bao, Mariamma Baptist, Tanya Baqai, Ananya M Baral, Sharad Chandra Baral, Desislava Baramova, Russel Barber, Emma Barbon, Monica Barbosa, Jamie Barbour, Alexander Barclay, Amanda Barclay, Claire Barclay, George Bardsley, Stephanie Bareford, Shahedal Bari, Morris Barimbing, Amy Barker, Debbie Barker, Erandi Barker, Helen Barker, Joseph Barker, Leon Barker, Lesley Barker, Oliver Barker, Kerry Barker-Williams, Sinha Barkha, Juliana Barla, Gavin Barlow, Richard Barlow, Valerie Barlow, James Barnacle, Alex Barnard, Debi Barnes, Nicky Barnes, Rory Barnes, Theresa Barnes, Calum Barnetson, Amy Barnett, Ashton Barnett-Vanes, Prince Gyenti Barning, William Barnsley, Andrew Barr, David Barr, James Barr, Charlotte Barr, Nina Barratt, Shaney Barratt, Manuella Barrera, Amy Barrett, Fiona Barrett, Jessica Barrett, Sue Barrett, Esther Barrow, Jazz Bartholomew, Claire Bartlett, Georgina Bartlett, James Bartlett, Louise Bartlett, Shauna Bartley, Sandra Bartolmeu-Pires, Anna Barton, Greg Barton, Jill Barton, Lorna Barton, Rachael Barton, Rosaleen Baruah, Sonia Baryschpolec, Hannah Bashir, Archana Bashyal, Betsy Basker, Sudha Basnet, Buddha Basnyat, Ayten Basoglu, Alexander Basran, John Bassett, G Bassett, Chris Bassford, Bengisu Bassoy, Victoria Bastion, Anup Bastola, Anupam Basumatary, Precious Basvi, Jireh A Batac, Vipula R Bataduwaarachchi, Tristan Bate, Harry J Bateman, Kathryn Bateman, Vhairi Bateman, Eleanor Bates, Hayley Bates, Michelle Bates, Simon Bates, Sally Batham, Ana Batista, Amit Batla, Dushyant Batra, Harry Batty, Thomas Batty, Alice Batty, Miranda Baum, Rachel Baumber, Carina Bautista, Fareha Bawa, Tanveer Bawa, Fatima S Bawani, Simon Bax, Matt Baxter, Nicola Baxter, Zachary Baxter, Hannah Bayes, Lee-Ann Bayo, Farid Bazari, Rohit Bazaz, Ahmad Bazli, Laura Beacham, Wendy Beadles, Kirsten Beadon, Philip Beak, Andy Beale, Kathy Beard, Jack Bearpark, Alanna Beasley, Sandee Beattie, Karen Beaumont, Dawn Beaumont-Jewell, Theresa Beaver, Sarah Beavis, Christy Beazley, Sarah Beck, Virginia Beckett, Rosie Beckitt, Sarah Beckley, Heidi Beddall, Seonaid Beddows, Deborah Beeby, Sophia Beeby, Gail Beech, Michelle Beecroft, Nigel Beer, Sally Beer, Jane Beety, Gabriela Bega, Alison Begg, Susan Begg, Sara Beghini, Ayesha Begum, Salman Begum, Selina Begum, Teresa Behan, Roya Behrouzi, Jon Beishon, Claire Beith, James Belcher, Holly Belfield, Katherine Belfield, Ajay Belgaumkar, Dina Bell, Gareth Bell, Gillian Bell, Jessica Bell, Lauren Bell, Louise Bell, Nicholas Bell, Pippa Bell, Stephanie Bell, Jennifer Bellamu, Mary Bellamy, Tammy Bellamy, Arianna Bellini, Amanda Bellis, Fionn Bellis, Lesley Bendall, Naveena Benesh, Nicola Benetti, Leonie Benham, Guy Benison-Horner, Sarah Benkenstein, Tracey Benn, Ann 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Flanagan, Charles Flanders, Nikolaos Flaris, Gail Fleming, Julie Fleming, Lucy Fleming, Paul Fleming, William Flesher, Alison Fletcher, Anna Fletcher, Jonathan Fletcher, Lucy Fletcher, Simon Fletcher, Sophie Fletcher, Fiona Flett, Karen Flewitt, Sarah Flockhart, Christopher Flood, Ian Floodgate, Jonathan Flor, Vincent Florence, Mary Flowerdew, Sharon Floyd, Margaret J Flynn, Rachel Flynn, Claire Foden, Adama Fofana, Georgina Fogarty, Paul Foley, Linda Folkes, Tracey Fong, Daniela M Font, Aiwyne Foo, Jane Foo, Andrew Foot, Helen R Foot, Jayne Foot, Jane Forbes, Amber Ford, Jamie Ford, Imogen Fordham, Jennifer Foreman, Matthew Forester, Mohammad Forkan, Caroline Fornolles, Adam Forrest, Ellie Forsey, Miranda Forsey, Thomas Forshall, Elliot Forster, Abigail Forsyth, Julian Forton, Conrad Foster, Emily Foster, Joseph Foster, Rachel A Foster, Tracy Foster, Angela Foulds, Ian Foulds, Folakemi Fowe, Natasha Fowkes, Emily Fowler, Robert Fowler, Stephen Fowler, Amy Fox, Claire Fox, Heather Fox, 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Giokanini-Royal, Anna Gipson, Barbie Giri, Joanna Girling, Rhian Gisby, Angelena Gkioni, Aikaterini Gkoritsa, Effrossyni Gkrania-Klotsas, Amy Gladwell, James Glanville, Jessica Glasgow, Susannah Glasgow, Jon Glass, Lynn Glass, Sharon Glaysher, Lisa Gledhill, Eleanor Glenday, Ana Glennon, Jodie Glossop, John Glover, Kyle Glover, Michelle Glover, Jan Glover Bengtsson, Deborah Glowski, Sharon Glynn, Chevanthy Gnanalingam, Julie Goddard, Wendy Goddard, Emily Godden, Jo Godden, Sarah Godlee, Emma Godson, Gillian Godwin, Sukanya Gogoi, Aiky Goh, Manjinder Gohel, Rebeca Goiriz, Sriya Gokaraju, Raphael Goldacre, Arthur Goldsmith, Portia Goldsmith, Darren Gomersall, Lucia Gomez, Raquel Gomez-Marcos, Ali Gondal, Celia Gonzalez, Jack Goodall, Vicky Goodall, Bob Goodenough, Anna Goodfellow, Laura Goodfellow, James Goodlife, Camelia Goodwin, Elizabeth Goodwin, Jayne Goodwin, Paula Goodyear, Rajiv Gooentilleke, Michelle Goonasekara, Sheila Gooseman, Shameer Gopal, Chris Gordon, Sally Gordon, Robin 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Hale, Jennie Hale, Carmel Halevy, Paul Halford, William Halford, Alaina Halim, Alistair Hall, Anthony Hall, Claire Hall, Elizabeth Hall, Fiona Hall, Helen Hall, Jennifer Hall, Kathryn Hall, Laura Hall, Jan Hallas, Kyle Hallas, Charles Hallett, Jackie Halliday, Akmal Hallman, Heather Halls, Maryam Hamdollah-Zadeh, Ifedadepo A Hamed-Adekale, Bilal Hameed, Mohammed Hameed, Raph L Hamers, Imran Hamid, Mohamad Hamie, Raymond Hamill, Bethany Hamilton, Fergus Hamilton, Gus Hamilton, Leigh Hamilton, Melanie Hamilton, Nicola Hamilton, Sara Hamilton, Ruth Hamlin, Eleanor Hamlyn, Beatrice Hammans, Shirley Hammersley, Kate Hammerton, Bev Hammond, Emily Hammond, Leah Hammond, Sally Hammond, Fiona Hammonds, Ibrahim Hamoodi, Karen Hampshire, James A Hampson, Jude Hampson, Lucy Hampson, Lisa Hamzah, Jenny Han, Ozan Hanci, Sadiyah Hand, Lala Handayani, Jasmine Handford, Soran Handrean, Nina K Handzewniak, Sarah Haney, Vu Thi Kim Hang, Sheharyar Hanif, E Hanison, Esther Hanison, Jennifer Hannah, Amy 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Ruth Hartley, Tom Hartley, William Hartrey, Phillipa Hartridge, Stuart Hartshorn, Alice Harvey, Angela Harvey, Anna Harvey, Max Harvey, Catherine Harwood, Helen Harwood, Zoe Harzeli, Brigitte Haselden, Kazi Hashem, Mohammed Hashimm, Tadaaki Hashimoto, Imranullah Hashmi, Jack Haslam, Zena Haslam, Grace Hasnip, Adil Hassan, Ali Hassan, Amro Hassan, Awab Hassan, Zeinab Hassan, Sapna Hassasing, Jane Hassell, Philip Hassell, Alex Hastings, Bethany Hastings, Janice Hastings, Sarah Hathaway-Lees, Jonathan Hatton, Jennifer Hau, May Havinden-Williams, Stefan Havlik, Daniel B Hawcutt, Kadean Hawes, Liz Hawes, Nicola Hawes, Lydia Hawker, Annie Hawkins, Joe Hawkins, Nancy Hawkins, W John Hawkins, Dan Hawley, Ed Hawley-Jones, Edward Haworth, Alasdair W Hay, Cathy Hay, Amna Hayat, Jamal Hayat, Mohamed-Riyal Hayathu, Anne Hayes, Jonas Hayes, Kate Hayes, Melony Hayes, Fiona Hayes, Patrick Hayle, Chloe Haylett, Antara Hayman, Melanie Hayman, Matthew Haynes, Richard Haynes, Rachel Hayre, Carole Hays, Sarah Haysom, James Hayward, Patrick Haywood, Hazel Haywood Hasford, Tracy Hazelton, Phoebe Hazenberg, Zhengmai He, Elizabeth Headon, Carrie Heal, Brendan Healy, Jessica L Healy, Amy Hearn, David Heasman, Angela Heath, Debbie Heath, Rowan Heath, Diane Heaton, Adam Heavens, Kerry Hebbron, Catherine Heckman, Gemma Hector, Sadie Heddon, Andy Hedges, Katrine Hedges, Cheryl Heeley, Elaine Heeney, Richard Heinink, Rajdeep Heire, Ingvild Helgesen, Joanne Hemingway, Ulla Hemmila, Beth Hemmings, Scott Hemphill, Deborah Hemsley, Abigail Henderson, Eilidh Henderson, Jennifer Henderson, Steven Henderson, Joanne Henry, Karol Henry, Lavinia Henry, Margo Henry, Natalie Henry, David Henshall, Gillian Herdman, Rosaleen Herdman-Grant, Morag Herkes, Lucas E Hermans, Fe Marie Hernandez, Emma Heron, Lisa Heron, William Herrington, Emilia Heselden, Peta Heslop, Tracey Heslop, Simon Hester, Emily Hetherington, Joseph Hetherington, Chamila Hettiarachchi, Pramodh Hettiarachchi, Hayley Hewer, John Hewertson, Anna Hewetson, Sue Hewins, Nicola Hewitson, Claire Hewitt, Davina Hewitt, Richard Hewitt, Samuel Hey, Robert S Heyderman, Mathis Heydtmann, Joseph Heys, Jonathan Heywood, Meg Hibbert, John Hickey, Naomi Hickey, Peter Hickey, Nicky Hickman, Alex Hicks, Jenny Hicks, Scott R Hicks, Phan Thi Thu Hien, Daniel Higbee, Lucy Higgins, Andrew Higham, Martin Highcock, Judith Highgate, Mondy Hikmat, Amanda Hill, Helen Hill, Joanne Hill, Lisa Hill, Lucy Hill, Phoebe Hill, Uta Hill, Annette Hilldrith, Catherine Hillman-Cooper, Jon Hilton, Zoe Hilton, Sarah Hinch, Andrew Hindle, Esther Hindley, Alice Hindmarsh, Paul Hine, Kim Hinshaw, Clare Hird, Claire Hirst, Lindsay Hirst, Jemma Hives, Htet M Hlaing, Benson Ho, David K K Ho, Rosemary Ho, Michaela Hoare, David Hobden, Gill Hobden, Maria Hobrok, Simon Hobson, Christopher Hodge, Simon Hodge, Lesley Hodgen, George Hodgetts, Holly Hodgkins, Sally Hodgkinson, David Hodgson, Helen Hodgson, Luke Hodgson, Sheila Hodgson, Gemma Hodkinson, Kenneth Hodson, 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Elizabeth Horsley, Sarah Horton, Jane Hosea, Toby Hoskins, Muhammad S Hossain, Rashed Hossain, Maxine Hough, Sarah Hough, Catherine Houghton, Kathryn Houghton, Rebecca Houlihan, Kay Housely, Hamish Houston, Roseanna Hovvels, Lee How, Laura Howaniec, Joanne Howard, Kate Howard, Laura Howard, Linda Howard, Lucy Howard, Megan Howard, Sarah Howard, Stuart Howard, Richard Howard-Griffin, Louise Howard-Sandy, Serena Howe, Alice Howell, Mark Howells, Lyn Howie, Kerry Howlett, Sophie Howlett, Ruth Howman, Josh Hrycaiczuk, Hein Htet, Naing Z Htoon, Su Htwe, Ying Hu, Chiang O H Huah, Sylvia Huang, Kelly Hubbard, Abby Huckle, Shahzya Huda, Alison Hudak, Lisa Hudig, Heather Hudson, Suzanne Hudson, Oli Hudson, Alison Hufton, Connor Huggins, Alistair Hughes, Caitlin Hughes, Emma Hughes, Gareth Hughes, Heather Hughes, Luke Hughes, Martin Hughes, Rachel Hughes, Rebecca Hughes, Samantha Hughes, Stephen Hughes, Vikki Hughes, Wesley Hughes, Lukas Huhn, Ching Hui, Ruth Hulbert, Diana Hull, Grace Hull, Robert Hull, Amanda Hulme, Peter Hulme, Wendy Hulse, George Hulston, Ryan Hum, Megan Hume, Charlotte Humphrey, Alasdair Humphries, Amy Humphries, Joanne Humphries, Charlotte Hunt, Fiona Hunt, Jane Hunt, Jonquil Hunt, Kristen Hunt, Luke Hunt, Molly Hunt, Sophie Hunt, Alexandra Hunter, Catherine Hunter, Ewan Hunter, Karl Hunter, Neil Hunter, Ross Hunter, Sophie Hunter, George Huntington, Fuad Huq, Elizabeth Hurditch, Judith Hurdman, Cian Hurley, Katrina Hurley, Mohammed A Husain, Syeda Y Husaini, Coralie Huson, Afreen Hussain, Chreif Hussain, Ibraar Hussain, Ifza Hussain, Mohammad Hussain, Mohammed Hussain, Muhammad Hussain, Reda Hussain, Rizwana Hussain, Samia Hussain, Sanniah Hussain, Yasmin Hussain, Mohammed Hussam El-Din, Samahir F E M Hussein, Ziad Hussein, Rebecca Hussey, Adiel Haqiq Hussien, Anja Hutchinson, Camille Hutchinson, Dorothy Hutchinson, Elizabeth Hutchinson, John Hutchinson, Claire Hutsby, Paula Hutton, Nguyen Quang Huy, Thuong Huyen, Tran Bang Huyen, Nguyen Thi Huyen Thuong, Hieu Huynh, Daniella Hydes, Jamie Hyde-Wyatt, Niamh Hynes, Megan Hyslop, Angeliki Iakovou, Katherine Ibison, Mazen Ibraheim, Abdalla Ibrahim, Ahmed Ibrahim, Asil Ibrahim, Javed Ibrahim, Mamoun Ibrahim, Mohamed Ibrahim, Wadah Ibrahim, Becky Icke, Adetokunbo Idowu Idowu, Muhammad Idrees, Nauman Idrees, Hina Iftikhar, Mawara Iftikhar, Chukwuemeka Igwe, Ogechukwu Igwe, Mohammad Ijaz, Amaju Ikomi, Clare Iles, Stamatina Iliodromiti, Mary Ilsley, Lorna Ilves, Fatima Mariam Ilyas, La'ali Imam-Gutierrez, Mohamed Iman, Christopher Imray, Haider Imtiaz, Jack Ingham, Jo Ingham, Julie Ingham, Rory Ingham, Tejas Ingle, Jennifer Inglis, Samantha Inglis-Hawkes, Anne Ingram, Luke Ingram, Tanya Ingram, Nicholas Innes, Peter Inns, Vithusha Inpadhas, Ken Inweregbu, Andreea A Ionescu, Ana Ionita, Ilian Petkov Iordanov, Anil Ipe, Javaid Iqbal, Madiha Iqbal, Mishal Iqbal, Mohammed Iqbal, Faisal Iqbal Sait, Iziegbe Irabor, Jane Ireland, Jamie Irisari, Robert Irons, Mohannad Irshad, Muhammad S Irshad, 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Jennings, Jacqui Jennings, Louise Jennings, Virginia Jennings, Ellen Jerome, Douglas Jerry, Greame Jervis, Ellen Jessup-Dunton, Jorge A Jesus Silva, Champa Jetha, Kishan Jethwa, Roshan Kumar Jha, Shaman Jhanji, Khoo Jian, Zhixin Jiao, Laura Jimenez, Ana Jimenez Gil, Jithin Jith, Teishel Joefield, Navraj Johal, Simran Johal, Karine Johannessen, Aisyah Johari, Annie John, Anu John, Maya John, Navin John, Emma Johns, Margaret Johns, Antoinette Johnson, Emma Johnson, Gillian Johnson, Kathryn Johnson, Katie Johnson, Luke Johnson, Mark Johnson, Nelsonseelan Johnson, Oliver Johnson, Rachel Johnson, Brogan Johnston, Claire Johnston, Janet Johnston, Susan Johnston, Victoria Johnston, Dawn Johnstone, Ed Johnstone, Janet Johnstone, Manohar Joishy, Adam Jones, Alistair Jones, Amy Jones, Angela Jones, Annabel Jones, Ben Jones, Bryony Jones, Carys Jones, Ceri Jones, Charlotte Jones, Christine E Jones, Debra Jones, Emily Jones, Gareth Jones, Geraldine Jones, Jac Jones, James Jones, Jonathon Jones, Julie Jones, Kate E Jones, Kimberly Jones, Laura Jones, Laura M Jones, Louise Jones, Mathew Jones, Nancy Jones, Nicola Jones, Olivia Jones, Paul Jones, Philip H Jones, Rhianna Jones, Ruth E Jones, Samantha Jones, Sophie Jones, Stefanie Jones, Steve Jones, Susan Jones, Taya Jones, Thomas Jones, Tim Jones, Tracey Jones, Ramya Jonnalagadda, Rebecca Jordache, Michele Jordan, Sarah Jordan, Abi Jose, Litty Jose, Louise Jose, Sanal Jose, Anna Joseph, Gigee Joseph, P Aiden Joseph, Rosane Joseph, Sibet Joseph, Dhaara Joshi, Mehul Joshi, Pratichi Joshi, Tushar Joshi, Benz Josiah, Lijo Joy, Tiffany Joyce, Hong Ju, Adriel Ju Wen Kwek, Andrew Judd, Edward Jude, Parminder Judge, Jessica Juhl, Sirisha Jujjavarapu, Mark Juniper, Edmund Juszczak, Deepthi Jyothish, Kasamu Kabiru Dawa, Mark Kacar, Nikhil Kadam, Nicole Kader, Ajai Kailey, Matthew Kain, Gail Kakoullis, Azad Kala Bhushan, Richard J K Kalayi, Roobala Kaliannan Periyasami, Efthymia Kallistrou, Thomas Kalmus Eliasz, Seika Kalsoom, Elisa Kam, 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Younes Ibrahim, Eoin Young, Gail Young, Louise Young, Asfand Yousafzar, Sajeda Youssouf, Ahmed Yousuf, Hartantri Yovita, Chrissie Yu, Jack S J Yuan, Nindya Yufaniaputri, Bernard Yung, Daniel Yusef, Said Yusef, Intekhab Yusuf, Anna-Sophia Zafar, Silvia Zagalo, Su Zaher, Aqsa Zahoor, Mahrukh Zainab, Thornton Zak, Kareem Zaki, Nabhan Zakir, Kasia Zalewska, Ane Zamalloa, Mohsin Zaman, Shakir Zaman, Julie Zamikula, Louise Zammit, Marie Zammit-Mangion, Marcelina Zawadzka, Mohammed Zayed, Esther Zebracki, Daniel Zehnder, Lisa Zeidan, Darius Zeinali, Jing Zhang, Xiaobei Zhao, Dongling Zheng, Doreen Zhu, Madiha Zia, Omar Zibdeh, Rabia Zill-E-Huma, Ei Thankt Zin, Eva Zincone, Garikai Zindoga, Eleanor Zinkin, Vivian Zinyemba, Christos Zipitis, Letizia Zitter, Arkadiusz Zmierczak, Garazi Zubikarai, Azam Zubir, Naz Zuhra, Rasha Zulaikha, Sabrina Zulfikar, Carol Zullo, Ana Zuriaga-Alvaro, University of St Andrews. Infection and Global Health Division, University of St Andrews. School of Medicine, and Group, RECOVERY Collaborative
Subjects: Adult, Male, Hypoxia/etiology, SARS-CoV-2, COVID-19, 3rd-DAS, General Medicine, Adrenal Cortex Hormones/therapeutic use, AC, Dexamethasone/therapeutic use, Hospitals, Oxygen, Treatment Outcome, SDG 3 - Good Health and Well-being, MCP, Humans, Female
Abstract: Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group. Methods This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised for COVID-19. Eligible and consenting adult patients with clinical evidence of hypoxia (ie, receiving oxygen or with oxygen saturation Findings Between May 25, 2021, and May 13, 2022, 1272 patients with COVID-19 and hypoxia receiving no oxygen (eight [1%]) or simple oxygen only (1264 [99%]) were randomly allocated to receive usual care plus higher dose corticosteroids (659 patients) versus usual care alone (613 patients, of whom 87% received low-dose corticosteroids during the follow-up period). Of those randomly assigned, 745 (59%) were in Asia, 512 (40%) in the UK, and 15 (1%) in Africa. 248 (19%) had diabetes and 769 (60%) were male. Overall, 123 (19%) of 659 patients allocated to higher dose corticosteroids versus 75 (12%) of 613 patients allocated to usual care died within 28 days (rate ratio 1·59 [95% CI 1·20–2·10]; p=0·0012). There was also an excess of pneumonia reported to be due to non-COVID infection (64 cases [10%] vs 37 cases [6%]; absolute difference 3·7% [95% CI 0·7–6·6]) and an increase in hyperglycaemia requiring increased insulin dose (142 [22%] vs 87 [14%]; absolute difference 7·4% [95% CI 3·2–11·5]). Interpretation In patients hospitalised for COVID-19 with clinical hypoxia who required either no oxygen or simple oxygen only, higher dose corticosteroids significantly increased the risk of death compared with usual care, which included low-dose corticosteroids. The RECOVERY trial continues to assess the effects of higher dose corticosteroids in patients hospitalised with COVID-19 who require non-invasive ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation. Funding UK Research and Innovation (Medical Research Council), National Institute of Health and Care Research, and Wellcome Trust.
Published: 2023
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10. 'Did I get into the twilight zone somehow?': sexual and gender minority cancer caregiver experiences during COVID

Author: Shoshana Adler Jaffe, Kendal Jacobson, Amy W. Farnbach Pearson, Lila A. Baca, Nina Dimauro, and Miria Kano
Subjects: Cancer Research, Oncology
Published: 2023
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11. Developing the Students’ Critical Thinking in Management Information System Courses through the Inquiry Method

Author: Nunung Agus Firmansyah, Lila Bismala, Yayuk Hayulina Manurung, Hafsah Hafsah, and Susi Handayani
Subjects: General Medicine
Abstract: One of the essential abilities expected to be created and grown after students take a specific class is the ability to think critically, which becomes an indicator of learning quality. Critical thinking skills are essential in life, which can be used to solve problems and issues, and will make a lifelong learner. This study aims to analyze the significance of the influence of the implementation of the inquiry method in improving students' critical thinking skills in the Management Information Systems course. The research was conducted on 168 students taking the Management Information Systems course in the Management Studies program at Universitas Muhammadiyah Sumatera Utara, but 113 returned questionnaires. The data analysis technique used is descriptive statistical analysis techniques and simple regression. The results showed a positive and significant effect of implementing the inquiry method on students' critical thinking skills in the management information system course. Meanwhile, the R Square value is 0.642, which means that the influence exerted by the inquiry method in increasing students' critical thinking is 64.2%. This can be used as a recommendation to improve the students' necessary thinking skills.
Published: 2023
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12. Safety and immunogenicity of homologous versus heterologous booster dose with AZD1222, mRNA-1273, or MVC-COV1901 SARS-CoV-2 vaccines in adults: An observer-blinded, multi-center, phase 2 randomized trial

Author: Lila Estephan, Ying-Chin Lin, Yi-Tsung Lin, Yen-Hsu Chen, Sung-Ching Pan, Szu-Min Hsieh, Paal Fure Torkehagen, Yi-Jen Weng, Hao-Yuan Cheng, Josue Antonio Estrada, Alexander Waits, Charles Chen, and Chia En Lien
Subjects: Infectious Diseases, General Veterinary, General Immunology and Microbiology, Public Health, Environmental and Occupational Health, Molecular Medicine
Published: 2023
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13. Neuropsychological Performance, Substance Misuse, and Recidivism in Intimate Partner Violence Perpetrators

Author: Ángel Romero-Martínez, Marisol Lila, Carolina Sarrate-Costa, Javier Comes-Fayos, and Luis Moya-Albiol
Subjects: Social Psychology, Developmental and Educational Psychology, Applied Psychology
Published: 2023
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14. Participants in Court-mandated Intervention Programs for Intimate Partner Violence Perpetrators with Substance Use Problems: A Systematic Review of Specific Risk Factors

Author: Cristina Expósito-Álvarez, Faraj A. Santirso, Gail Gilchrist, Enrique Gracia, and Marisol Lila
Subjects: Social Psychology, Developmental and Educational Psychology, Applied Psychology
Published: 2023
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15. Case report: Confirming a diagnosis of severe olmesartan-associated enteropathy

Author: Lucien, Roulet, Lucia, Bedatsova, Laurent, Merz, Jules, Desmeules, and Lila, Saiah
Subjects: Pharmacology (medical)
Published: 2023
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16. New pharmaconutraceutical Chondroguard®TRIO for the prevention of musculoskeletal diseases and nutritional support for patients with osteoarthritis and nonspecific back pain: an assessment of clinical options. Resolution of the Multidisciplinary Expert Council

Author: Al. B. Danilov, A. M. Lila, Yo. N. Majidova, O. A. Gromova, O. N. Tkacheva, I. V. Sarvilina, A. Yu. Kochish, A. G. Nazarenko, N. V. Zagorodniy, T. B. Minasov, L. I. Alekseeva, E. A. Taskina, Yu. V. Kotovskaya, E. N. Dudinskaya, A. V. Rozanov, E. Yu. Solovieva, O. A. Shavlovskaya, M. N. Sharov, P. R. Kamchatnov, A. P. Rachin, E. R. Barantsevich, D. A. Iskra, E. Z. Yakupov, F. I. Devlikamova, A. E. Barulin, M. V. Nesterova, T. G. Sakovets, A. N. Barinov, I. N. Dolgova, N. V. Zabolotskikh, E. V. Zonova, L. A. Shchepankevich, V. A. Parfenov, A. T. Dzhurabekova, and S. Z. Khakimova
Subjects: Psychiatry and Mental health, Clinical Psychology, Neurology (clinical)
Abstract: In recent decades, there has been an increase in the prevalence and medical and social burden of osteoarthritis (OA) and nonspecific back pain in all countries of the world. The First Multidisciplinary Bilateral Russia-Uzbekistan Expert Council presented innovations in the prognosing, personalized prevention and adjuvant therapy of degenerative-dystrophic diseases of the joints and spine, the evidence base for the effectiveness and safety of the use of drugs that modify the course of OA (Disease-modifying osteoarthritis drugs, DMOADs): chondroitin sulfate, glucosamine sulfate, undenatured type II collagen for adjuvant pharmaconutraceutical support – prevention and adjuvant therapy (treatment) of OA and nonspecific lumbosacral pain. The expert counsil resolution presents an optimized algorithm for the management, prevention and adjuvant therapy of OA and non-specific back pain, maintaining the function of healthy joints after intense physical activity with the inclusion of the drug Chondroguard solution for intra-articular and intramuscular administration (INN – chondroitin sulfate) and a new pharmaconutraceutical from the DMOADs group – TRIO trademark Chondroguard® (Chondroguard®TRIO).
Published: 2023
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17. Treatment Resistant Perpetrators of Intimate Partner Violence: Research Advances

Author: Marisol Lila and Gail Gilchrist
Subjects: Social Psychology, Developmental and Educational Psychology, Applied Psychology
Published: 2023
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18. Unveiling determinant of student engagement

Author: Gustina Siregar, Lila Bismala, Hafsah Hafsah, Susi Handayani, Yayuk Hayulina Manurung, Dewi Andriany, and Lailan Safina Hasibuan
Subjects: General Agricultural and Biological Sciences
Abstract: The purpose of this study was to examine the moderating role of feedback in the influence between lecturer leadership, lecturer engagement, and student engagement. The study was conducted on students at the Universitas Muhammadiyah Sumatera Utara, Indonesia where the number of respondents who filled out the questionnaire was 231 respondents. With structural equation modeling, using SemPLS, a moderation test was conducted to prove the research hypothesis that had been designed. The results of the study show that although feedback affects student engagement, feedback does not act as a moderator in the influence between lecturer leadership, lecturer engagement, and student engagement. Meanwhile, lecturer engagement was found not to affect student engagement, but lecturer engagement significantly affected student engagement. In learning, lecturers must pay attention to feedback and lecturer leadership, if lecturers expect high student engagement. This has implications that lecturers have to provide feedback and practice lecturer leadership in the classroom.
Published: 2023
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19. Hubungan Dukungan Suami dan Sikap Ibu Hamil Trimester III Terhadap Kesiapan Menghadapi Persalinan di Masa Pandemi COVID-19 di Puskesmas Gerokgak I

Author: Ketut Eka Larasati Wardana, Kadek Lila Damayanti, and Desak Ketut Sugiartini
Abstract: Background: The current Covid-19 pandemic greatly affects the condition of pregnant women, especially when they are about to face childbirth. Attention and support from the closest people, especially husbands, are very helpful in overcoming the anxiety experienced by pregnant women in facing childbirth in the Covid-19 era. Purpose: of this study was to determine the relationship between husband support and the attitude of third trimester pregnant women towards readiness to face childbirth during the Covid 19 pandemic at the Gerokgak I Primary Health Care. Method: used is quantitative analysis with a cross sectional approach using primary data with a data collection instrument in the form of a questionnaire distributed to 134 respondents where the sampling technique used is the Non Probability Sampling technique with the purposive sampling method conducted from September to November 2021. at the Grokgak I Primary Health Care. Results: showed p value
Published: 2023
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20. Quality of life of patients with rheumatoid arthritis and comorbid fibromyalgia

Author: N. A. Melikova, E. S. Filatova, E. G. Filatova, and A. M. Lila
Subjects: Psychiatry and Mental health, Clinical Psychology, Neurology (clinical)
Abstract: Objective: to evaluate the impact of comorbid fibromyalgia (FM) on the quality of life (QoL) of patients with rheumatoid arthritis (RA). Material and methods. The study involved 90 patients with confirmed RA who complained of chronic pain. All patients underwent general clinical and laboratory examination. FM was diagnosed according to the 2016 ACR criteria. The questionnaires assessed the presence and severity of fatigue (FSS), anxiety and depression (HADS), sleep disorders (PSQI), cognitive impairment (DSST), symptoms of central sensitization (CSI) and the neuropathic component of pain (DN4, PD). The severity of pain syndrome (PS) was assessed by 10-cm VAS at rest. QoL was assessed using the EQ-5D questionnaire. Results. In the main (FM+) and control (FM-) groups, the average severity of PS according to VAS at rest was 7 and 4 cm (pConclusion. Concomitant FM significantly reduces the QoL of patients with RA. The main factors affecting QoL in patients with RA and comorbid FM were the intensity and neuropathic phenotype of PS, increased fatigue and anxiety. Patients with FM are also significantly more likely to have sleep and cognitive impairments.
Published: 2023
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21. Study on Compensation, Organizational Commitment, and Work Motivation for Employee Retention at a Local Hospital

Author: null Lila Maria Kaban and null Umi Kulsum
Abstract: Human resource management is critical for hospitals but is frequently disturbed by employee retention issues. This research aims to determine the influence of compensation, organizational commitment, and work motivation on employee retention at Malahayati Medan. The research method applied is quantitative research by collecting data through questionnaires distributed from July to October 2022. The sampling method used is purposive sampling, with 78 employees as the sample. The data analysis method used is descriptive statistics, coefficient determination, multiple linear regression analysis, and hypothesis testing with t-test and F-test. The results of the t-test are compensation, organizational commitment, and work motivation partially influence employee retention. The results of the F test showed that all independent variables simultaneously influence employee retention and 61.1% of employee retention is influenced by compensation, organizational commitment, and work motivation. It is recommended for companies in similar industries pay attention to the results of this research
Published: 2023
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22. Dynamic Properties of a Compacted Residual Soil from the West Indies

Author: Lila Mouali, Guillaume Veylon, Daniel Dias, Laurent Peyras, Claudio Carvajal, Jérôme Duriez, and Eric Antoinet
Subjects: residual soils, dynamic properties, small-strain shear modulus, normalized shear modulus, damping ratio, pore pressure build up, General Medicine
Abstract: This paper presents a laboratory investigation of the strain-dependent cyclic properties of a compacted tropical residual soil as measured in a resonant column and cyclic triaxial testing program. The mechanical properties were evaluated with respect to cyclic shear strain amplitude, initial void ratio, and confining pressure. It was shown that the existing models for the prediction of shear modulus reduction and damping ratio curves were not pertinent in the case of the compacted residual soil studied. Empirical equations were developed for the small-strain shear modulus and the normalized shear modulus, damping ratio, and pore water pressure ratio curves for void ratios between e = 1.00 and e = 1.50 and mean effective pressures of p′ = 50−300 kPa. The comparison of the models to the measured values suggest that the uncertainties associated with each of these models are lower than 20% of the predicted values. The results were established as part of a project for the construction of an embankment dam in the West Indies. However, the methodology as well as the model formulation framework presented in the article can be generalized to other residual soils and applied in all fields of geotechnical engineering.
Published: 2023
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23. Features of clinical manifestations of rheumatoid arthritis in patients after failure of conventional synthetic disease-modifying antirheumatic drugs therapy depending on the signs of central sensitization

Author: A. S. Potapova, A. E. Karateev, E. Yu. Polishchuk, E. V. Matyanova, T. S. Panevin, A. S. Semashko, A. O. Bobkova, A. R. Khalmetova, E. S. Filatova, V. N. Amirjanova, and A. M. Lila
Subjects: Rheumatology, Immunology, Immunology and Allergy
Abstract: Central sensitization (CS) is a condition characterised by (associated with) neuroplastic changes in nociceptive neurons, sub-threshold afferent input, pain hypersensitivity and development widespread pain. Insufficient response to disease-modifying antirheumatic drugs (DMARDs) can be caused by CS.Objective – to evaluate the features of clinical manifestations of RA in patients with ineffective antirheumatic therapy, depending on the presence of signs of CS.Material and methods. The study group included 509 patients diagnosed with RA (according to ACR/EULAR classification criteria, 2010) with moderate or high disease activity (DAS28-CRP≥3.2) and ineffectiveness or intolerance of conventional synthetic DMARDs, biological DMARDs and JAK inhibitors. Disease activity in patient with RA was assessed by DAS28-CRP. Our study did not include an examination by a neurologist to detect signs of CS, so the Central Sensitization Inventory (CSI) (part one) was used. The BPI questionnaire was used for assessing clinical pain intensity. The PainDETECT, FSS, FIRST, HAQ questionnaires were used for screening neuropathic pain symptoms (NPS), fatigue, fibromyalgia signs and functional impairment, respectively. The HADS questionnaire was recommended for early diagnosis anxiety and depression disorders.Results. Signs of CS (CSI≥40), with a median of 42 [32; 53], were found in 57.2% of the examined patient. Patients with signs of CS were established to have poorer health measure (PGA – 64.6±13.5 and 53.5±16.8; p=0.001), higher pain intensity in all BPI scales, longer morning stiffness – 90 [30; 180] and 60 [20; 120] minutes (p=0.001), more painful joints – 8 [5; 12] and 7 [4; 10] (p=0.005), worse functional status in HAQ (1.65±0.7 and 1.08±0.5; p=0.001) and higher disease activity in DAS28-CRP (4.9±1.0 and 4.6±0.9; p=0.001) compared to patients without signs of CS. There was also direct correlation between CS and a high frequency of having an NPS (PainDETECT>18) – 34.5% and 10.3% (p=0.001), significant anxiety and depression (HADS>11) – 29,0% and 5.1% (p=0.001) and 26.3% and 4.2% (p=0.001) respectively, fatigue (FSS) – 96.5% and 70.4% (p=0.001), signs of fibromyalgia (FIRST≥5) – 38.4% and 6.1% (p=0.001).Conclusion. The presence of signs of CS in patient with RA significantly enhance many symptoms of disease, being associated with higher pain intensity, fatigue, impaired function, higher incidence of NPS, depression and anxiety, and fibromyalgia.
Published: 2023
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24. Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression

Author: Zachariah P. Tritz, Katayoun Ayasoufi, Delaney M. Wolf, Carley A. Owens, Courtney S. Malo, Benjamin T. Himes, Cori E. Fain, Emma N. Goddery, Lila T. Yokanovich, Fang Jin, Michael J. Hansen, Ian F. Parney, Chensu Wang, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup, Rosa M. Diaz Marcano, Richard G. Vile, and Aaron J. Johnson
Subjects: Cancer Research, Immunology
Abstract: Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for approximately 225,000 deaths per year. Despite preclinical successes, most interventions have failed to extend patient survival by more than a few months. Treatment with anti—programmed cell death protein 1 (anti–PD-1) immune checkpoint blockade (ICB) monotherapy has been beneficial for malignant tumors such as melanoma and lung cancers but has yet to be effectively employed in GBM. This study aimed to determine whether supplementing anti–PD-1 ICB with engineered extended half-life IL2, a potent lymphoproliferative cytokine, could improve outcomes. This combination therapy, subsequently referred to as enhanced checkpoint blockade (ECB), delivered intraperitoneally, reliably cures approximately 50% of C57BL/6 mice bearing orthotopic GL261 gliomas and extends median survival of the treated cohort. In the CT2A model, characterized as being resistant to CBI, ECB caused a decrease in CT2A tumor volume in half of measured animals similar to what was observed in GL261-bearing mice, promoting a trending survival increase. ECB generates robust immunologic responses, features of which include secondary lymphoid organ enlargement and increased activation status of both CD4 and CD8 T cells. This immunity is durable, with long-term ECB survivors able to resist GL261 rechallenge. Through employment of depletion strategies, ECB's efficacy was shown to be independent of host MHC class I–restricted antigen presentation but reliant on CD4 T cells. These results demonstrate ECB is efficacious against the GL261 glioma model through an MHC class I–independent mechanism and supporting further investigation into IL2-supplemented ICB therapies for tumors of the central nervous system.
Published: 2023
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25. Aspectos afetivos e experiência: Representações sociais do parto em mulheres assistidas por enfermeiros e médicos

Author: Elisângela Euripedes Resende Guimarães and Lila Spadoni
Subjects: Materials Science (miscellaneous)
Abstract: Objetivo: Analisar experiências de mulheres assistidas durante o parto pelo enfermeiro obstetra e médico, para verificar se a atuação desses profissionais modifica as representações sociais do parto normal. Método: Estudo descritivo fundamentado na Teoria das Representações Sociais, desenvolvido em unidades da estratégia de saúde da família, localizadas em Goiânia-Goiás, com mulheres no período puerperal tardio. Os dados foram tratados por meio do Software de Análise e Evocação e de Similitude, as análises estatísticas foram realizadas no Excel, versão 2016. Resultado: A experiência das mulheres assistidas no parto normal pelo enfermeiro obstetra são mais positivas e agradáveis em comparação às mulheres em que o parto foi realizado por médicos. As Representações Sociais do parto assistido por enfermeiro obstetra e médico são diferentes, bem como a experiência. Conclusão: A assistência proporcionada pelo enfermeiro obstetra é experienciada como saudável e tranquila, enquanto que a prestada pelo médico é tranquila, porém marcada pelo medo.
Published: 2023
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26. Rheumatoid arthritis: historical aspects

Author: I. N. Shchedrigin and A. M. Lila
Subjects: Rheumatology, Immunology, Immunology and Allergy, Pharmacology (medical)
Abstract: The historical essay presents the main stages in the development of scientific views on rheumatoid arthritis, starting from the middle of the 19th century and until the middle of the 20th century, history of research of its characteristic clinical and instrumental signs, diagnostic criteria, methods of drug therapy.
Published: 2023
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27. Alflutop Russian longitudinal multicentre observational study: preliminary results (message 1)

Author: A. M. Lila, L. I. Alekseeva, E. A. Taskina, and N. G. Kashevarova
Subjects: Rheumatology, Immunology, Immunology and Allergy, Pharmacology (medical)
Abstract: Evaluation of the effect of new drugs should be carried out in randomized controlled trials (RCTs), and observational studies (OSs) are carried out to confirm and refine the results obtained in RCTs, for example, to study the effectiveness of drugs in large groups of patients who were not included in RCTs or had comorbidities or older age.Objective: to evaluate the effectiveness of Alflutop (AF) via OS of patients with osteoarthritis (OA) of the knee and/or hip joints and/or low back pain (LBP) with or without comorbid diseases.Material and methods. A multicenter prospective cohort OS was conducted in 163 clinical centers in 58 cities of the Russian Federation and included 22,525 patients with OA and LBP who received AF as a part of a planned treatment prescribed by a doctor, or self-prescribed and purchased in a pharmacy. Pain, satisfaction with therapy, health assessment, need for non-steroidal anti-inflammatory drugs (NSAIDs), and quality of life were recorded using the EQ-5D questionnaire.Results and discussion. After one treatment course with AF, improvement was detected in 98% of cases, there was a rapid positive trend with a significant decrease in pain, the median time to clinical effect was 8 [5; 10] days. Assessment of general health status and satisfaction with therapy improved significantly. In 94.5% of patients, the daily requirement for NSAIDs decreased.Conclusion. The first results from the OS confirm the symptomatic effect of AF.
Published: 2023
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28. Rheumatoid arthritis and cardiovascular diseases: close relatives or friends?

Author: A. V. Gordeev, Yu. A. Olyunin, E. A. Galushko, E. G. Zotkin, and A. M. Lila
Subjects: Rheumatology, Immunology, Immunology and Allergy, Pharmacology (medical)
Abstract: The problem of comorbidity is widely discussed in modern medical literature. Its role in rheumatic diseases is of particular interest due to their multifactorial nature and the involvement of a wide range of pathogenetic mechanisms. For many years, researchers around the world have noted correlations between the presence of active autoimmune disorders and the complicated course of cardiovascular diseases. A deeper understanding of the pathogenetic mechanisms at the present stage of development of rheumatology allows us to take a fresh look at the relationship between atherosclerosis and rheumatoid arthritis. The definition of multimorbidity developed in recent years and the results of recent scientific studies may contribute to a more correct choice of tactics for managing patients with a combination of these two diseases.
Published: 2023
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29. Introduction. L’antiracisme en France : enjeux, métamorphoses et controverses au prisme du décès de George Floyd (vol. 2)

Author: Lila Belkacem, Fanny Gallot, and Francine Nyambek-Mebenga
Subjects: General Agricultural and Biological Sciences
Published: 2023
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30. « L’étude de la médiatisation de la marche permet d’articuler la question des mémoires et l’histoire de l’antiracisme »

Author: Sophie Gebeil, Lila Belkacem, Fanny Gallot, and Francine Nyambek-Mebenga
Subjects: General Agricultural and Biological Sciences
Published: 2023
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31. Photon Activation Analysis in Gallium, Nickel, and Vanadium

Author: Robert Bentley, Geno Santistevan, Douglas Wells, Andrew Hutton, Adam Stavola, Steve Benson, Kevin Jordan, Joe Gubeli, Pavel Degtiarenko, and Lila Dabill
Subjects: Nuclear Energy and Engineering
Published: 2023
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32. L’importance du dispositif de groupe dans la prise en charge de la pathologie somatique

Author: Aglaïa-Lila Mitsopoulou-Sonta
Subjects: Psychiatry and Mental health, Clinical Psychology
Published: 2023
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33. Modern approaches to the management of patients with osteoarthritis in real clinical practice

Author: A. M. Lila and L. I. Alekseeva
Subjects: General Medicine
Abstract: Osteoarthritis (OA) is a heterogeneous condition, which is based on low-intensity infl ammation that aff ects all tissues of the joint, and allows it to be considered as an organ pathology, that is, a disease of the whole organ — the joint. The article presents algorithms for managing a patient with OA, including non-drug, pharmacological treatment and surgical interventions. Drug treatment consists of three stages of sequential prescription of medications. The early use of symptomatic slow-acting drugs in osteoarthritis (SYSADOA) is emphasized. It increases the eff ectiveness of treatment, reduces pain, improves joint function, and thereby improves the quality of life of patients.
Published: 2023
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34. Glycosaminoglycan-peptide complex: data on the mechanism of action and efficacy in osteoarthritis

Author: N. V. Chichasova and A. M. Lila
Subjects: General Medicine
Abstract: The article presents the modern definition of osteoarthritis (OA) not as a degenerative cartilage injury, but as a disease in which abnormal adaptive regenerative processes are activated, including pro-inflammatory pathways of the immune system, based on the clarification of the pathogenesis of the disease. An approach to the separation of various OA phenotypes is described. Various approaches to the tactics of pharmacological treatment of the disease are presented. The possibilities of the glycosaminoglycan-peptide complex to influence the state of chondrocytes and cartilage tissue in various experimental models of induced OA are described. And in the last experimental study, a positive effect of the drug on the clinical manifestations of 2 models of induced OA was demonstrated, a decrease in the concentration of CRP, interleukin 1β was recorded with an increase in the concentration of anti-inflammatory cytokines (interleukins 4 and 10), a significant decrease in the number of leukocytes in the synovial fluid, as well as a decrease in pathological changes in cartilage during histological examination, which it indicates that the drug exerts its effect directly in the tissues of the joint. Clinical studies have confirmed the analgesic and anti-inflammatory activity of the glycosaminoglycan-peptide complex in OA, although not all conducted in the twentieth century, the positive effect on joint pain and joint function was significantly better than placebo. The absence in these years of regulated criteria for inclusion in studies of the effectiveness of pharmacological drugs in OA, the introduction of new methods for assessing pain, function served as a prerequisite for conducting studies of the effectiveness and tolerability of the glycosaminoglycan-peptide complex at the present stage. Multicenter observational studies, which included massive groups of patients with OA of various localization, confirmed the presence of analgesic and anti-inflammatory activity in the drug, manifested during the 1st course of injections, showed that repeated courses of drug administration are necessary to achieve a more pronounced and stable effect. Data on an increase in the effect of combination therapy with diacerein and on the possibility of achieving an effect in patients with previous insufficient efficacy of other slow-acting symptomatic drugs are presented.
Published: 2023
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35. EVALUATING OF ACCOUNTING INFORMATION SYSTEM LITERATURE ON WEB OF SCIENCE (WOS) DATABASE

Author: Tanti Handriana and Lila Sabrinta Marditaputri
Subjects: General Medicine
Abstract: Artikel ini bertujuan untuk mengkaji dan menganalisis topik Sistem Informasi Akuntansi (SIA) yang dipublikasikan dalam database Web of Science. Penelitian ini menggunakan metode Bibliometrik melalui Vos Viewer dan Biblioshiny untuk menunjukkan informasi mengenai tren set, frekuensi produksi artikel, frekuensi penulis, dan beberapa informasi lainnya. Hasil penelitian menunjukkan bahwa penelitian SIA yang pertama kali dipublikasikan dalam database Web of Science tercatat sejak 1975 dan mencapai puncaknya di tahun 2011. Namun puncak produksi artikel SIA pada tahun 2011 disebabkan karena adanya simposium yang dilakukan di China. Namun setelah itu produksi artikel SIA terus menurun dan dalam periode 2012-2021 cenderung meningkat. Hasil lainnya menunjukkan bahwa tidak ada peneliti yang fokus memproduksi artikel penelitian SIA secara konsisten, hal ini dibuktikan dengan penulis yang paling banyak mempublikasikan artikel SIA hanya sebanyak 4 artikel. Publikasi yang rendah ini membuktikan bahwa kolaborasi antar peneliti SIA sangat kurang sehingga banyak artikel yang berstatus single author.
Published: 2023
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36. Potensi Muck Dive di Perairan Kecamatan Buleleng Bali

Author: I Nyoman Dodik Prasetia, Gede Iwan Setiabudi, Kadek Lila Antara, Jasmine Masyitha Amelia, Gressty Sari Br Sitepu, Made Dwipa Kusuma Maharani, Dewi Wulandari, and I Nyoman Suardana
Subjects: Organic Chemistry, Biochemistry
Abstract: Kawasan Pesisir Kecamatan Buleleng terdiri dari Pantai Desa Kalibukbuk, Anturan, Tukad Mungga, Pemaron, Baktiseraga, Banyuasri, Kaliuntu, Kampung Anyar, Kampung Bugis, Kampung Baru, Banyuning, dan Penarukan merupakan kawasan perairan yang berada di pusat Kabupaten Buleleng. Perairan Kecamatan Buleleng memiliki karakteristik subsrat perairan berupa hamparan terumbu karang, patahan karang, pasir yang didominasi oleh pasir hitam, dan berlumpur. Kondisi subsrat memiliki potensi pengembangan wisata muck dive sebagai alternatif wisata bahari yang berkelanjutan. Muck dive merupakan jenis penyelaman yang dilakukan di subsrat berlumpur dengan berfokus untuk menemukan jenis langka dan samar yang jarang ditemukan di terumbu karang. Penelitian bertujuan mengetahui potensi muck dive dengan memperkuat data identifikasi jenis, kelimpahan dan keanekaragaman organisme yang dapat dijadikan sebagai ikon obyek wisata selam. Peneltian menggunakan metode underwater visual sensus dengan mengikuti line transect. Penelitian menunjukkan Perairan Kecamatan Buleleng memiliki potensi pengembangan wisata muck dive dengan karakteristik di setiap perairan desa yang beragam berdasarkan tipe subsrat perairan. Kelimpahan dan keanekaragaman jenis organisme sebagai obyek muck dive tertinggi terdapat di Pantai Desa Baktiseraga, Banyuasri, dan Kaliuntu, sedangkan terendah di Desa Kampung Anyar, Kampung Bugis, Kampung Baru, Banyuning, dan Penarukan. Potensi wisata muck dive layak dikembangkan sebagai alternatif wisata bahari yang dikelola secara berkelanjutan. The coastal area of Buleleng districts consists of Kalibukbuk, Anturan, Tukad Mungga, Pemaron, Baktiseraga, Banyuasri, Kaliuntu, Kampung Anyar, Kampung Bugis, Kampung Baru, Banyuning, and Penarukan are water areas located in the center of Buleleng Regency. The Buleleng districts water have the characteristics of the water substrate in the form of coral reefs, coral fractures, sand dominated by black sand, and muddy. Substrate conditions have the potential to increase muck dive tourism as an alternative to sustainable marine tourism. Muck dive is a type of diving that is carried out in muddy substrates with a focus on finding rare and rare species that are rarely found in coral reefs. This study aims to determine the potential of muck dive by strengthening the identification data of species, abundance and diversity of organisms that can be used as icons of diving tourism objects. The research uses the underwater visual census method by following the line transect.The research shows that the Buleleng districts waters have the potential to develop muck dive tourism with different characteristics in each village waters based on the type of substrate. The highest abundance and diversity of organisms as muck dive objects was found in Baktiseraga, Banyuasri, and Kaliuntu Beaches, while the lowest was in Kampung Anyar, Bugis, Kampung Baru, Banyuning, and Penarukan villages. This potential to be the one of alternative for marine tourism which is must managed sustainably.
Published: 2023
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37. Penerapan Bank Energi Surya sebagai Sumber Energi Mandiri untuk Penerangan Masyarakat di Dusun Batu Ampar Desa Mulyorejo

Author: Riofaldi Putra Aditama, Dimas Dwi Febrian, Lila Ratna Indah Lestari, Silfiatul Mukaromah, Rijal Daivu Duri, and Risse Entikaria Rachmanita
Subjects: General Medicine
Abstract: Solar Energy Bank is an activity of the Community Service Student Creativity Program (PKM-PM) in collaboration with Ayo Berbagi (ABG) partners and given to 24 houses of Dusun Batu Ampar RT 04/RW 17 which still do not have access to the PLN electricity network so that lighting conditions at night are very poor. The purpose of this program is to implement the Solar Energy Bank as an alternative source of electrical energy for night lighting with emergency lights and Internet of Things (IoT) based monitoring systems. The program implementation method uses 3 implementation techniques, extension techniques through socialization, then science and technology assistance techniques include preparation and implementation activities, and the third is training and mentoring techniques. Benchmarks for the success of community services activities are measured by questionnaires given to society before and after implementation of the solar energy bank. Based on the result of the questionnaire, the implementation of the Solar Energy Bank has helped solve lighting problems, provided community service satisfaction and increased knowledge regarding the use of solar energy as an alternative energy source and skills in operating the Solar Energy Bank for the people of Dusun Batu Ampar RT 04/RW 17.
Published: 2023
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38. New laterite-based geopolymer foam resistance under drastic conditions: A comparative study with a metakaolin model

Author: Nouping Fekoua Joelle Nadia, Ameni Gharzouni, Benoit Nait-Ali, Lila Ouamara, Ibrahim Mbouombouo Ndassa, Gouet Bebga, Kamseu Elie, and Sylvie Rossignol
Subjects: Process Chemistry and Technology, Materials Chemistry, Ceramics and Composites, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Published: 2023
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39. 4 Algorithmic Governmentality and Managerial Fascism: The Case of Smart Cities

Author: Goda Klumbytė and Lila Athanasiadou
Published: 2023
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40. Tumor lineage-specific immune response in brain metastatic disease

Author: Shiva Najjary, Johan M. Kros, Willem de Koning, Disha Vadgama, Karishma Lila, Janina Wolf, Dana A. M. Mustafa, Pathology, and Pulmonary Medicine
Subjects: Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, 570 Life sciences, biology, 610 Medicine & health, Neurology (clinical), Pathology and Forensic Medicine
Abstract: Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain metastasis is demanding. The aim of this study was to compare the brain (immune) response to brain metastases of the most common tumor lineages, viz., lung adenocarcinoma and breast cancer. Targeted gene expression profiles of 11 brain metastasis of lung adenocarcinoma (BM-LUAD) were compared to 11 brain metastasis of breast cancer (BCBM) using NanoString nCounter PanCancer IO 360™ Panel. The most promising results were validated spatially using the novel GeoMx™ Digital Spatial Profiler (DSP) Technology. Additionally, Immune cell profiles and expression of drug targets were validated by multiplex immunohistochemistry. We found a more active immune response in BM-LUAD as compared to BCBM. In the BM-LUAD, 138 genes were upregulated as compared to BCBM (adj. p ≤ 0.05). Conversely, in BCBM 28 genes were upregulated (adj. p ≤ 0.05). Additionally, genes related to CD45 + cells, T cells, and cytotoxic T cells showed to be expressed higher in BM-LUAD compared to BCBM (adj. p = 0.01, adj. p = 0.023, adj. p = 0.023, respectively). The spatial quantification of the immune cells using the GeoMx DSP technique revealed the significantly higher quantification of CD14 and CD163 in tumor regions of BM-LUAD as compared to BCBM. Importantly, the immune checkpoint VISTA and IDO1 were identified as highly expressed in the BM-LUAD. Multiplex immunohistochemistry confirmed the finding and showed that VISTA is expressed mainly in BM-LUAD tumor cells, CD3 + cells, and to fewer levels in some microglial cells in BM-LUAD. This is the first report on differences in the brain immune response between metastatic tumors of different lineages. We found a far more extensive infiltration of immune cells in BM-LUAD as compared to BCBM. In addition, we found higher expression of VISTA and IDO1 in BM-LUAD. Taken together, targeted immune therapy should be considered to treat patients with BM-LUAD.
Published: 2023
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41. Exploring antiretroviral therapy adherence, competing needs, and viral suppression among people living with HIV and food insecurity in the Dominican Republic

Author: Claudio Lugo, Gabriela Armenta, Glenn J. Wagner, Yeycy Donastorg, Amarilis Then-Paulino, Ramon Acevedo, Isidro Veloz, Gipsy Jimenez-Paulino, Lila A. Sheira, Bing Han, Kathryn Pitkin Derose, and Kartika Palar
Subjects: Health (social science), Social Psychology, Human immunodeficiency virus (HIV), HIV Infections, Pilot Projects, medicine.disease_cause, Odds, Food Supply, Medication Adherence, Social support, Environmental health, medicine, Humans, Viral suppression, Depression (differential diagnoses), business.industry, Dominican Republic, Public Health, Environmental and Occupational Health, Viral Load, Haiti, Food insecurity, Food Insecurity, Anti-Retroviral Agents, business, Psychosocial, Viral load
Abstract: Understanding factors related to suboptimal adherence to antiretroviral therapy (ART) and detectable viral load (VL), especially among vulnerable populations, is needed to improve HIV outcomes. The Caribbean is highly impacted by HIV and socioeconomic inequalities, but few studies have been conducted there to explore food insecurity among people with HIV and factors associated with viral suppression in this vulnerable population. Using baseline data from a pilot intervention trial among people living with HIV and food insecurity in the Dominican Republic, we examined psychosocial and behavioral factors associated with viral suppression, ART adherence, and competing needs. Among participants (n = 115), 61% had a detectable VL; the strongest factor associated with detectable VL was having missed taking ART in the last six months due to not having food (OR = 2.68, p = 0.02). Greater odds of reporting missed ART doses due to not having food were associated with severe food insecurity (OR = 4.60, p = 0.006), clinical depression (OR = 2.76, p = 0.018), Haitian background (OR = 6.62 p = 0.017), and internalized HIV stigma (OR = 1.09, p = 0.041), while lower odds were associated with social support (OR = 0.89, p = 0.03) and having health insurance (OR = 0.27, p = 0.017). Ensuring that people with HIV and food insecurity have food to take with their ART is essential for viral suppression.
Published: 2023

42. Trends in Stimulant Prescription Fills Among Commercially Insured Children and Adults — United States, 2016–2021

Author: Melissa L. Danielson, Michele K. Bohm, Kimberly Newsome, Angelika H. Claussen, Jennifer W. Kaminski, Scott D. Grosse, Lila Siwakoti, Aziza Arifkhanova, Rebecca H. Bitsko, and Lara R. Robinson
Subjects: Health (social science), Health Information Management, Epidemiology, Health, Toxicology and Mutagenesis, General Medicine
Published: 2023
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43. No change in avilamycin (Surmax® Premix) minimum inhibitory concentration for Clostridium perfringens isolates recovered from poultry up to 7 years post-approval in Canada

Author: Shabbir Simjee, George Gould, Lila Maduro, Martine Boulianne, Andrew Pridmore, and Eric Parent
Subjects: Pharmacology, Microbiology (medical), Infectious Diseases, Pharmacology (medical)
Abstract: Background Clostridium perfringens, the causative agent of necrotic enteritis (NE) in chickens, has an enormous economic impact on global broiler production. The non-medically important antibiotic avilamycin was approved in Canada in 2014 to prevent and control NE in broiler chickens. Objectives To compare avilamycin susceptibility in C. perfringens isolates collected pre- and 7 years post-avilamycin approval in Canada and determine the avilamycin resistance mutation frequency rate in C. perfringens. Methods The MICs of avilamycin were determined for 89 strains of C. perfringens recovered from clinically relevant NE field cases pre-avilamycin approval between 2003 and 2013 (n = 50) and post-avilamycin approval between 2014 and 2021 (n = 39) across Canada. For determining the mutant prevention concentration (MPC) of avilamycin for C. perfringens strains, a strain with avilamycin MIC of 1 mg/L was randomly selected. Results MIC studies showed no difference in avilamycin susceptibility in pre-avilamycin and post-avilamycin isolates (MIC50/90: pre-avilamycin approval 2/2 mg/L and post-avilamycin approval 1/2 mg/L). The MPC was 8 × MIC (8 mg/L) for the selected strain. Conclusions These findings suggest that the susceptibility of C. perfringens strains to avilamycin was not impacted by its continued use in the 7 years following its approval in Canada. Avilamycin, a non-medically important antibiotic, poses no threat to human health regarding cross-resistance or co-selection of other medically important antibiotics. These factors make avilamycin an appropriate choice for continued use in broiler chickens to prevent and control NE without increased antimicrobial resistance concerns.
Published: 2023
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44. Atom-und Atommüllpolitik in Japan : Ein Jahrzehnt nach Fukushima

Author: Okamura, Lila
Subjects: Atommüllpolitik in Japan, 論文|ARTICLES, Atompolitik in Japan, Fukushima
Abstract: Until recently, it appeared as if nuclear power in Japan had been rendered a taboo subject by the Fukushima nuclear disaster. The Russian invasion of Ukraine, however, has led to a drastic change in that situation. Burdened with increased energy prices, the Japanese government now intends not only to ramp up its use of nuclear power, but to develop and construct next-generation nuclear power plants. This would be the first time since the nuclear accident in Fukushima Daiichi that a Japanese government has clearly committed itself to building new nuclear power plants.In Japan the discussion about nuclear energy has focused hitherto on the aspect of energy supply. There has rarely been an effort here to concentrate attention or effort to the high-level radioactive waste which is produced during electricity generation. Moreover, the disposal of radioactive waste from the Fukushima reactor accident is proving to be extremely difficult. The term "radioactive waste" here should incorporate both these sources of nuclear waste.Thus far, nuclear policy and nuclear waste policy in Japan have been discussed independently of each other. The purpose of this article is twofold: to elucidate the situation in this country with regard to both current nuclear policy and to radioactive waste, and to identify the challenges facing Japan as it seeks to formulate and implement its future nuclear policy.
Published: 2023

45. Generalized absolute convergence of single and double Vilenkin-Fourier series and related results

Author: Bhikha Lila Ghodadra and Nayna Govindbhai Kalsariya
Published: 2023
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46. Native solitary bee reproductive success depends on early season precipitation and host plant richness

Author: Lila R. Westreich, Samuel T. Westreich, and Patrick C. Tobin
Subjects: Ecology, Evolution, Behavior and Systematics
Published: 2023
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47. Gain stability improvement of a wideband antenna using an artificial magnetic conductor

Author: Safia Chenaoui, Lila Mouffok, Sami Hebib, Amina Fattouche, Dahmane Allane, and Smail Tedjini
Subjects: Electrical and Electronic Engineering, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published: 2023
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48. Inactivation of E. faecalis under microwave heat treatment and ultrasound probe

Author: Ourdia-Nouara Kernou, Amine Belbahi, Kenza Bedjaoui, Ghania Kaanin-Boudraa, Lila Boulekbache-Makhlouf, and Khodir Madani
Subjects: General Engineering
Abstract: Background and aims: The Weibull model was fitted to survival curves in order to describe inactivation kinetics, and the effect of combined microwave (MW) and ultrasound (US) treatments was evaluated. Methods: Enterococcus faecalis ATCC 29212 present in 40 mL of sterile physiological water was treated with microwaves at 300W, 600W, and 900W and/or ultrasonic probes (amplitude 60 %, 80 % and 100 %, pulse (3s continuous, 3s discontinuous). Results: The use of an ultrasonic probe at 20 kHz displayed no significant impact on the patients' ability to survive. At 600 W and 300 W of MW treatment, a decrease of 3.96 log and 0.90 log, respectively, was obtained. Total destruction was accomplished in 70 seconds when 900 W of microwave therapy was used. Additionally, it was shown that the effectiveness of WM and US increased with increasing power and exposure duration. This was the case even when microwave or ultrasonic technology was utilized independently. In addition, the treatment that included both microwaves and ultrasound showed a significantly better effect than the treatment that only involved microwaves, but there were no significant differences between the coupled treatment and the microwave treatment given for 30 seconds. Conclusions: The results of the current study show that the inactivation of Enterococcus faecalis by ultrasound followed by microwave treatment was significantly higher than that obtained by microwave treatment followed by ultrasound. Keywords: Enterococcus faecalis, ultrasound, microwave, inactivation.
Published: 2023
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49. Efficacy and safety of levilimab in combination with methotrexate in patients with active rheumatoid arthritis: 56-week results of phase III randomized double-blind placebo-controlled trial SOLAR

Author: V. I. Mazurov, A. M. Lila, M. A. Korolev, A. M. Prystrom, A. V. Kundzer, N. F. Soroka, A. A. Kastanayan, T. V. Povarova, T. V. Plaksina, O. V. Antipova, D. G. Krechikova, S. A. Smakotina, O. A. Tciupa, E. V. Puntus, T. A. Raskina, L. N. Shilova, T. V. Kropotina, O. B. Nesmeyanova, T. A. Popova, I. B. Vinogradova, E. A. Dokukina, A. V. Plotnikova, P. S. Pukhtinskaia, A. V. Zinkina-Orikhan, Yu. N. Linkova, A. V. Eremeeva, A. A. Lutckii, and E. L. Nasonov
Subjects: Rheumatology, Immunology, Immunology and Allergy
Abstract: Background. Previously, 24-week results of phase III double-blind, placebo-controlled randomized clinical study (SOLAR) of levilimab in subjects with active rheumatoid arthritis (RA) proved a superiority of levilimab over placebo. Here we present 1-year efficacy and safety data of the SOLAR study.Objective – to evaluate the efficacy and safety of levilimab in combination with methotrexate (MTX) in subjects with MTX resistant active RA.Methods. The study was conducted at 21 clinical sites in Russia and Belarus. All randomized subjects have completed the study between November 2019 and October 2021.154 adults, aged ≥18 years with confirmed diagnosis of RA were randomly assigned (2:1) to receive either levilimab (162 mg, SC, QW) + MTX (n=102) or placebo + MTX (n=52).After W24 of the study all subjects continued to receive open label levilimab. Subjects who have achieved DAS28-CRP≤2.6 at W24 were switched to maintenance (Q2W) regimen of levilimab at W28 (LVL QW/Q2W and PBO/LVL Q2W arms). Those with DAS28-CRP>2.6 at W28 continued with QW regimen (LVL QW and PBO/LVL QW arm). The PBO/LVL Q2W arm contained only one subject, thus not included in the analysis. The efficacy analysis was done in a population of all randomized subjects. Those with missing data due to study discontinuation or rescue therapy prescription were considered non-responders. Otherwise, the analysis was performed on complete cases.Safety was assessed through monitoring of adverse events (AEs) in a population of those, who received at least on dose of LVL (n=152).Results. Better response to treatment was observed in LVL QW/Q2W as it composed of those who reach DAS28-CRP≤2.6 at W24. At this time point 15/27 (55.6%) of them achieved ACR70; 23/27 (85.2%) achieved DAS28-CRP remission (Mycobacterium tuberculosis antigen positive (7.2%) and injection site reactions (5.9%). No deaths were occurred.Conclusions. Open label period confirmed the lasting efficacy and safety of levilimab in combination with MTX in subjects with MTX resistant active RA and suggested the possibility of switching to maintenance (Q2W) regimen in those who achieved remission of RA at week 24.
Published: 2023
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50. The pillars of inclusive education for students with ASD: a scoping review based on the case of Spain

Author: Lila Kossyvaki and María Isabel Vidal Esteve
Subjects: Psychiatry and Mental health, Developmental and Educational Psychology
Published: 2023
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