1. Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness
- Author
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Swann, A. C., Lijffijt, M., Lane, S. D., Steinberg, J. L., and Moeller, F. G.
- Subjects
Adult ,Male ,Psychotropic Drugs ,Bipolar Disorder ,Models, Statistical ,Substance-Related Disorders ,Suicide, Attempted ,Antisocial Personality Disorder ,Neuropsychological Tests ,Personality Assessment ,Severity of Illness Index ,Article ,Medical Records ,Diagnostic and Statistical Manual of Mental Disorders ,Recurrence ,Impulsive Behavior ,Interview, Psychological ,Humans ,Drug Interactions ,Female ,Behavioral Research - Abstract
We investigated trait impulsivity in bipolar disorder and antisocial personality disorder (ASPD) with respect to severity and course of illness.Subjects included 78 controls, 34 ASPD, 61 bipolar disorder without Axis II disorder, and 24 bipolar disorder with ASPD, by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-I and -II). Data were analyzed using general linear model and probit analysis.Barratt Impulsiveness Scale (BIS-11) scores were higher in ASPD (effect sizes 0.5-0.8) or bipolar disorder (effect size 1.45) than in controls. Subjects with both had more suicide attempts and previous episodes than bipolar disorder alone, and more substance-use disorders and suicide attempts than ASPD alone. BIS-11 scores were not related to severity of crimes.Impulsivity was higher in bipolar disorder with or without ASPD than in ASPD alone, and higher in ASPD than in controls. Adverse effects of bipolar disorder in ASPD, but not of ASPD in bipolar disorder, were accounted for by increased impulsivity.
- Published
- 2010