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Your search keyword '"Libby, Tanya"' showing total 2 results
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2 results on '"Libby, Tanya"'

1. Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1–July 25, 2020

Author

Kim, Lindsay, Whitaker, Michael, O’Halloran, Alissa, Kambhampati, Anita, Chai, Shua J., Reingold, Arthur, Armistead, Isaac, Kawasaki, Breanna, Meek, James, Yousey-Hindes, Kimberly, Anderson, Evan J., Openo, Kyle P., Weigel, Andy, Ryan, Patricia, Monroe, Maya L., Fox, Kimberly, Kim, Sue, Lynfield, Ruth, Bye, Erica, Shrum Davis, Sarah, Smelser, Chad, Barney, Grant, Spina, Nancy L., Bennett, Nancy M., Felsen, Christina B., Billing, Laurie M., Shiltz, Jessica, Sutton, Melissa, West, Nicole, Talbot, H. Keipp, Schaffner, William, Risk, Ilene, Price, Andrea, Brammer, Lynnette, Fry, Alicia M., Hall, Aron J., Langley, Gayle E., Garg, Shikha, Coates, Ashley, Daily Kirley, Pam, Libby, Tanya, Roland, Jeremy, Alden, Nisha, Herlihy, Rachel, McLafferty, Sarah, Clogher, Paula, Kayalioglu, Hazal, Maslar, Amber, Misiorski, Adam, Niccolai, Linda, Olson, Danyel, Parisi, Christina, Fawcett, Emily, Gretzinger, Siyeh, Lengacher, Katelyn, Williams, Jeremiah, Blythe, David, Brooks, Alicia, Park, Rachel, Wilson, Michelle, Como-Sabetti, Kathryn, Danila, Richard, Cline, Cory, Angeles, Kathy, Eisenberg, Nancy, Flores, Kristina, Habrun, Caroline, Hancock, Emily, Khanlian, Sarah, Novi, Meaghan, Phipps, Erin, Salazar-Sanchez, Yadira, Dufort, Elizabeth, Muse, Alison, Bushey, Sophrena, Gaitan, Maria, Kurtz, RaeAnne, Owusu-Dommey, Ama, Snyder, Lindsey, Michaelis, Katherine, Seeley, Kylie, Markus, Tiffanie, Chatelain, Ryan, George, Andrea, Hill, Mary, McCullough, Laine, Spencer, Melanie, Swain, Ashley, McCaffrey, Keegan, Holstein, Rachel, Meador, Seth, and Wortham, Jonathan

Subjects
Male, Pediatric Obesity, Pediatrics, Health (social science), Epidemiology, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Severity of Illness Index, law.invention, 0302 clinical medicine, Health Information Management, Risk Factors, law, Ethnicity, Full Report, 030212 general & internal medicine, Child, education.field_of_study, Medical record, General Medicine, Clinical Laboratory Services, Intensive care unit, Hospitalization, Child, Preschool, Female, medicine.symptom, Coronavirus Infections, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, Population, Asymptomatic, Betacoronavirus, 03 medical and health sciences, 030225 pediatrics, Severity of illness, medicine, Humans, education, Pandemics, Mechanical ventilation, SARS-CoV-2, business.industry, Infant, Newborn, COVID-19, Infant, medicine.disease, United States, Pneumonia, Chronic Disease, business
Abstract

Most reported cases of coronavirus disease 2019 (COVID-19) in children aged

Published
2020

2. Dermcidin expression is associated with disease progression and survival among breast cancer patients

Author

Lampe, Paul D., Libby, Tanya E., D'Arcy, Monica, Troester, Melissa A., Thompson, Henry J., Hamajima, Nobuyuki, Brauer, Heather Ann, Yasui, Yutaka Y., and Li, Christopher I.

Abstract

Improved diagnostic screening has led to earlier detection of many tumors, but screening may still miss many aggressive tumor types. Proteomic and genomic profiling studies of breast cancer samples have identified tumor markers that may help improve screening for more aggressive, rapidly growing breast cancers. To identify potential blood-based biomarkers for the early detection of breast cancer, we assayed serum samples via matrix-assisted laser desorption ionization–time of flight mass spectrometry from a rat model of mammary carcinogenesis. We found elevated levels of a fragment of the protein dermcidin (DCD) to be associated with early progression of N-methylnitrosourea-induced breast cancer, demonstrating significance at weeks 4 (p = 0.045) and 5 (p = 0.004), a time period during which mammary pathologies rapidly progress from ductal hyperplasia to adenocarcinoma. The highest serum concentrations were observed in rats bearing palpable mammary carcinomas. Increased DCD was also detected with immunoblotting methods in 102 serum samples taken from women just prior to breast cancer diagnosis. To validate these findings in a larger population, we applied a 32-gene in vitro DCD response signature to a dataset of 295 breast tumors and assessed correlation with intrinsic breast cancer subtypes and overall survival. The DCD-derived gene signature was significantly associated with subtype (p < 0.001) and poorer overall survival [HR (95 % CI) = 1.60 (1.01–2.51), p = 0.044]. In conclusion, these results present novel evidence that DCD levels may increase in early carcinogenesis, particularly among more aggressive forms of breast cancer.

Published
2014
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