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Additional file 1. Supplementary File S1. Cuproptosis-related genes selected by genome-wideCRISPR-Cas9 loss-of-function screens after treatment with elesclomol-copper inOVISE cells. Supplementary Table 1. Differences in clinicopathological characteristics betweenICGC training set and ICGC validation set. Supplementary Figure 1. The hazard ratio of three genes was calculated bymultivariate Cox regression analysis in the prognostic model. Supplementary Figure 2. Evaluation of prognostic model in the GEO testing set. (A)The risk score, survival time, survival status, and 3-gene expression trend in thetesting set (GSE85916, 80 samples). (B) ROC curves for the sensitivity andspecificity of one-, two-, and three-year OS according to the risk score in theGEO-testing set. (C) Kaplan–Meier curve for OS between the high- and low-riskgroups in the GEO-testing set. Supplementary Figure 3. Comparison of the molecular characteristics and immunelandscapes between the risk groups. (A) Correlation between the risk score and TMB.The Spearman correlation coefficients (R) and corresponding p values are shown. (B)The relationship between the risk score and MSI in TCGA-PAAD cohort. (C) Theexpression levels of representative immune checkpoint genes in the high- andlow-risk PAAD patients from the TCGA cohort. * p < 0.05; ** p < 0.01; *** P

Action advising is a knowledge transfer technique for reinforcement learning based on the teacher-student paradigm. An expert teacher provides advice to a student during training in order to improve the student's sample efficiency and policy performance. Such advice is commonly given in the form of state-action pairs. However, it makes it difficult for the student to reason with and apply to novel states. We introduce Explainable Action Advising, in which the teacher provides action advice as well as associated explanations indicating why the action was chosen. This allows the student to self-reflect on what it has learned, enabling advice generalization and leading to improved sample efficiency and learning performance - even in environments where the teacher is sub-optimal. We empirically show that our framework is effective in both single-agent and multi-agent scenarios, yielding improved policy returns and convergence rates when compared to state-of-the-art methods, This work has been published by ICRA 2023(979-8-3503-2365-8/23/$31.00 copyright 2023 IEEE)

Objective: To investigate the effects of “Yingwei Fang” on nitric oxide synthase (eNOS), endothelin-converting enzyme (ECE) and homocysteine (Hey) in patients with type 2 diabetes mellitus. Methods: 39 cases of type 2 diabetes mellitus with different syndromes were observed, including 14 cases of Yin deficiency heat, 10 cases of Qi and Yin deficiency and 15 cases of Yin and Yang deficiency. All patients took “Yingwei Fang” capsules orally, 5 capsules per time, 3 times a day. At the same time, they were combined with conventional treatment such as dialectical TCM dialectical theory of treatment and hypoglycemia. The changes of eNOS, ECE and Hcy were measured after 150 days of treatment and compared with those before treatment. RESULTs: After treatment, there were changes in $e$ NOS, ECE and Hcy in patients with Yin deficiency, Qi and Yin deficiency and Yin and Yang deficiency, among which eNOS, ECE and Hcy were significantly improved (P

Objective: To investigate the effect of lowering sugar and preventing deafness prescription on blood glucose in animal models of diabetic deafness. Methods: Fifty Wistar rats were randomly selected from 40 rats to establish the animal model of experimental diabetic deafness by intraperitoneal injection of 55mg/kg streptozotocin (STZ). The remaining 10 rats were normal control group (group A), and after modeling, they were randomly divided into model control group (group B), low-concentration group (group C) and high-concentration group (group D) of the suspension of the formula for lowering sugar and preventing deafness, metformin control group (group E). Group A was fed the normal diet and given the same dose of normal saline as the other groups, group B was given the same dose of normal saline as the other groups, and the metformin groups in groups C, D and E were given 3.3g/kg.d, 30g/kg.d and 0.3mg/kg.d of hypoglycemic and anti-hearing suspension and metformin aqueous solution, respectively. The administration period was 30 days. Results: Compared with normal control group, fasting blood glucose in model control group was increased, the difference was statistically significant (P 0.05), and the indexes of each dose group of Jiangtang Fang Deaf Formula were not statistically significant compared with the metformin control group (P BBB>05). Conclusion: Jiangtang Fang Deafness Decoction can improve the blood glucose of diabetic deafness animal models.

Objective: To investigate the changes of ankle-brachial index (ABI) and peak velocity of dorsal foot artery in patients with type 2 diabetes mellitus with lower extremity vascular disease treated with Yingweifang. Methods: 36 cases of type 2 diabetes mellitus with lower extremity vascular disease were observed, including 13 cases of Yin deficiency and hot, 9 cases of qi and Yin deficiency and 14 cases of Yin and Yang deficiency. Oral “Yingwei Fang” capsule, 5 capsules per time, 3 times a day, combined with the dialectical TCM dialectical theory of treatment, conventional treatment such as hypoglycemia. Changes in the ankle-brachial index (ABI) and peak flow rate of dorsal foot artery were measured after 150 days of treatment compared with before treatment. RESULTS: After treatment, ABI and peak flow rate of dorsal foot artery in diabetic lower extremity vascular disease patients were changed in different degrees (P < 0.05, P

Objective: To observe the changes of parathyroid hormone and osteocalcin in diabetic patients with different syndromes. Methods: The changes of parathyroid hormone (I-PTH) and osteocalcin (BGP) in 39 patients (50 ears) with different types of diabetes mellitus and deafness were detected. The control group was 20 normal people. Results: The level of I-PTH in diabetic patients with deafness had no significant change compared with the normal control group (P >0.05), but the level of I-PTH in diabetic patients with deafness had significant change (P>0.05). The level of BGP in qi-yin deficiency group and yin-yang deficiency group was significantly changed compared with the normal group (P

Corner separation is a key factor affecting the aerodynamic performance of compressors, whereas corner separation under a high-Mach-number condition is a scientific problem with practical engineeri...

Additional file 1: Table S1. List of genes included in the 1021 genes panel.

Context information plays an indispensable role in the success of semantic segmentation. Recently, non-local self-attention based methods are proved to be effective for context information collection. Since the desired context consists of spatial-wise and channel-wise attentions, 3D representation is an appropriate formulation. However, these non-local methods describe 3D context information based on a 2D similarity matrix, where space compression may lead to channel-wise attention missing. An alternative is to model the contextual information directly without compression. However, this effort confronts a fundamental difficulty, namely the high-rank property of context information. In this paper, we propose a new approach to model the 3D context representations, which not only avoids the space compression but also tackles the high-rank difficulty. Here, inspired by tensor canonical-polyadic decomposition theory (i.e, a high-rank tensor can be expressed as a combination of rank-1 tensors.), we design a low-rank-to-high-rank context reconstruction framework (i.e, RecoNet). Specifically, we first introduce the tensor generation module (TGM), which generates a number of rank-1 tensors to capture fragments of context feature. Then we use these rank-1 tensors to recover the high-rank context features through our proposed tensor reconstruction module (TRM). Extensive experiments show that our method achieves state-of-the-art on various public datasets. Additionally, our proposed method has more than 100 times less computational cost compared with conventional non-local-based methods., ECCV2020. Top-1 performance on PASCAL-VOC12; Source code at https://github.com/CWanli/RecoNet.git

A composite adaptive model predictive control (MPC) scheme is proposed to mitigate model mismatches due to parameter uncertainties and disturbances in controller designs for DC-DC boost converters. First, a model-based feedforward compensator based on a cascade proportional-integral (PI) MPC controller was developed as a current reference to improve the dynamic response performance. Then, an observer was employed to construct an accurate model and thereby avoid overcompensation and poor prediction due to model mismatch. Finally, a finite control set MPC was implemented to select a suitable switching state with which to realise output voltage regulation. Compared with a traditional PI MPC, the proposed controller has a rapid dynamic response, and compared with an unknown offset free MPC, the proposed controller is well suited to a simplified model. The proposed methods and benefits were validated by simulations in MATLAB/Simulink and by experiments on an NI Compact RIO rapid control prototype test bench.

Federated learning (FL) aims to train machine learning models in the decentralized system consisting of an enormous amount of smart edge devices. Federated averaging (FedAvg), the fundamental algorithm in FL settings, proposes on-device training and model aggregation to avoid the potential heavy communication costs and privacy concerns brought by transmitting raw data. However, through theoretical analysis we argue that 1) the multiple steps of local updating will result in gradient biases and 2) there is an inconsistency between the expected target distribution and the optimization objectives following the training paradigm in FedAvg. To tackle these problems, we first propose an unbiased gradient aggregation algorithm with the keep-trace gradient descent and the gradient evaluation strategy. Then we introduce an additional controllable meta updating procedure with a small set of data samples, indicating the expected target distribution, to provide a clear and consistent optimization objective. Both the two improvements are model- and task-agnostic and can be applied individually or together. Experimental results demonstrate that the proposed methods are faster in convergence and achieve higher accuracy with different network architectures in various FL settings., This manuscript has been accepted to the Workshop on Federated Learning for Data Privacy and Confidentiality (FL - NeurIPS 2019, in Conjunction with NeurIPS 2019)

The existence of wheel-diameter difference of track locomotive will directly affect the motion performance of locomotive. In this paper, the creep force of coaxial wheel-diameter difference is analysed, and the dynamic model of 2-axle bogie locomotive is established by SIMPACK software. Based on the study of two typical wheel-diameter difference of the same bogie, 10 special working conditions of wheel-diameter differences of the same locomotive are put forward. The effects of different working conditions and different wheel-diameter differences of the same working condition on the straight line motion performance of locomotive are analysed. The results show that, the lateral displacement and lateral ride quality index of locomotive body increase with the increase of wheel-diameter difference under the same working condition, and they do not exceed the safety limit. The change of wheel-diameter difference has little effect on the vertical ride quality index of locomotive body. According to the lateral displacement of the locomotive body, the 10 working conditions are divided into three grades. The third grade (working condition 4, working condition 5, working condition 8 and working condition 11) is more conducive to the safe and stable motion of the locomotive. Therefore, in the wheel matching installation and repairing process, priority should be given to the arrangement of wheel-diameter difference of the same locomotive in the third grade. This will provide a reference and basis for the scheme of locomotive wheel economic repairing.

Dissertation, RWTH Aachen University, 2019; Jülich : Forschungszentrum Jülich GmbH, Zentralbibliothek, Verlag, Schriften des Forschungszentrums Jülich. Reihe Energie & Umwelt = Energy & environment 472, 1 Online-Ressource (II, 119 Seiten) : Illustrationen, Diagramme (2019). = Dissertation, RWTH Aachen University, 2019, At present, High-temperature polymer electrolyte fuel cells (HT-PEFCs) are usually constructed using graphite bipolar plates (BPPs). Although continuous efforts have been made to increase their properties and reduce their volume, weight, and cost, graphite BPPs are still far from the requirements of the U.S. Department of Energy (DOE). However, metallic BPPs produced from thin metal foils are promising candidates for reaching DOE targets. The high temperature (ca. 120 °C-180 °C) and the use of phosphoric acid as electrolyte within the HT-PEFC provide a significantly aggressive environment for the components of HT-PEFC, and especially in metallic BPPs. In this thesis, stainless steel 316L (SS316L) is chosen as the substrate for the metallic BPPs, due to its reasonable degree of corrosion resistance and low cost. The corrosion properties of SS316L and the influence of gases on the corrosion behavior of SS316L in the simulated HT-PEFC environment were thoroughly examined. It is extremely difficult for bare metallic materials to reach the acceptable level of corrosion rates of HT-PEFC. Therefore, a protective coating is mandatory for the application of metallic BPPs in HT-PEFC. Based on the initial results by which a type of Cr-rich layer formed in the simulated cathodic environment of HT-PEFC was found able to tolerate the aggressive environment of hot phosphoric acid under an O2 purged atmosphere, a bilayer CrN/Cr coating was chosen as the coating research object for this work. This work investigated the corrosion behavior of bilayer CrN/Cr-coated SS316L BPPs in the simulated environment of HT-PEFC, and its self-healing ability when artificially induced defects appeared on its surface. Finally, the performances and durability of the CrN/Cr-coated SS316L BPPs were validated in a real HT-PEFC.A series of experiments revealed that CrN/Cr-coated SS316L demonstrates superior performance in the HT-PEFC environment, even including a degree of self-healing ability when defects appeared on its surface in an O2 purged atmosphere. Therefore, this work has demonstrated that bilayer CrN/Cr-coated SS316L is a promising candidate as a low-cost metallic BPP in HT-PEFCs., Published by Forschungszentrum Jülich GmbH, Zentralbibliothek, Verlag, Jülich

Albeit intensively studied, false prediction and unclear boundaries are still major issues of salient object detection. In this paper, we propose a Region Refinement Network (RRN), which recurrently filters redundant information and explicitly models boundary information for saliency detection. Different from existing refinement methods, we propose a Region Refinement Module (RRM) that optimizes salient region prediction by incorporating supervised attention masks in the intermediate refinement stages. The module only brings a minor increase in model size and yet significantly reduces false predictions from the background. To further refine boundary areas, we propose a Boundary Refinement Loss (BRL) that adds extra supervision for better distinguishing foreground from background. BRL is parameter free and easy to train. We further observe that BRL helps retain the integrity in prediction by refining the boundary. Extensive experiments on saliency detection datasets show that our refinement module and loss bring significant improvement to the baseline and can be easily applied to different frameworks. We also demonstrate that our proposed model generalizes well to portrait segmentation and shadow detection tasks., Comment: Tech report

At present, High-temperature polymer electrolyte fuel cells (HT-PEFCs) are usually constructed using graphite bipolar plates (BPPs). Although continuous efforts have been made to increase their properties and reduce their volume, weight, and cost, graphite BPPs are still far from the requirements of the U.S. Department of Energy (DOE). However, metallic BPPs produced from thin metal foils are promising candidates for reaching DOE targets. The high temperature (ca. 120 °C-180 °C) and the use of phosphoric acid as electrolyte within the HT-PEFC provide a significantly aggressive environment for the components of HT-PEFC, and especially in metallic BPPs. In this thesis, stainless steel 316L (SS316L) is chosen as the substrate for the metallic BPPs, due to its reasonable degree of corrosion resistance and low cost. The corrosion properties of SS316L and the influence of gases on the corrosion behavior of SS316L in the simulated HT-PEFC environment were thoroughly examined. It is extremely difficult for bare metallic materials to reach the acceptable level of corrosion rates of HT-PEFC. Therefore, a protective coating is mandatory for the application of metallic BPPs in HT-PEFC. Based on the initial results by which a type of Cr-rich layer formed in the simulated cathodic environment of HT-PEFC was found able to tolerate the aggressive environment of hot phosphoric acid under an O$_{2}$ purged atmosphere, a bilayer CrN/Cr coating was chosen as the coating research object for this work. This work investigated the corrosion behavior of bilayer CrN/Cr-coated SS316L BPPs in the simulated environment of HT-PEFC, and its self-healing ability when artificially induced defects appeared on its surface. Finally, the performances and durability of the CrN/Cr-coated SS316L BPPs were validated in a real HT-PEFC.A series of experiments revealed that CrN/Cr-coated SS316L demonstrates superior performance in the HT-PEFC environment, even including a degree of self-healing ability when defects appeared on its surface in an O$_{2}$ purged atmosphere. Therefore, this work hasdemonstrated that bilayer CrN/Cr-coated SS316L is a promising candidate as a low-cost metallic BPP in HT-PEFCs.

attached as file.

Stability property is the key index for converter control. A practical stable control scheme is proposed for DC power supply converters. Firstly, the converter system is described as a linear model with two constraints, one is that the input is discontinuous and it is a Finite Control Set (FCS), the other is that the switching frequency is limited. Secondly, a unified control design method satisfied the constraints to guarantee the practical stability and convergence called sampling point equivalence scheme is introduced, which is illustrated as the duty cycle feedback control in form. Then the relationship between the convergent zone and the sampling time is analyzed, which is also the character of practical stability. The DC-DC buck converter is chosen as the plant to show the proposed methods, which are finally validated by both simulation and experiments.

Objective: To explore the comparison of innovative new techniques and traditional endoscopic treatment of maxillary cysts. Methods: 32 cases of maxillary bone cyst patients were divided into two groups, 17 cases in the treatment group received innovative new technology in the treatment of maxillary bone cyst. 15 cases in the control group received nasal passages open window under traditional nasal endoscope in treatment. The cure rate, average hospitalization days, the average hospitalization expenses, postoperative complications and postoperative discomfort, satisfactory rate were observed and compared, respectively. Results: The patients of treatment group can be treated without hospitalization. While in the control group average hospitalization expenses, postoperative complications, postoperative discomfort, patient satisfaction were not as good as those of treatment group. Conclusion: It was more prominent of safety, effective rate and satisfaction in the treatment group than in the control group.

Diabetes mellitus (DM) is a chronic systemic disease characterized by hyperglycemia, with various pathogenic mechanisms. From absolute or relative insulin deficiency, patients with DM often demonstrate various levels of metabolic disorders. Major clinical manifestations of DM include metabolic disorders, vascular lesions, circulatory disturbances and neurologic complications. Along with advances in DM research, reports of DM related tinnitus and hearing impairment have increased continuously. Research on DM related auditory system dysfunction has focused on cochlear microcirculation, cellular homeostasis, genetics and aging. Cochlear microcirculation plays an important role in cochlear physiology and its disorders are associated with many inner ear diseases. Ischemia and subsequent reperfusion seen in cochlear microcirculation disorders are important factors in hearing damage. Understanding cochlear microcirculation and structural as well as functional changes in DM patients with hearing loss and their causal factors will help reveal pathogenic mechanisms in diabetic hearing loss and provide new ideas in developing interventions and preventing damages caused by diabetes.

Objective: To observe the curative effect of maxillary bone cyst by maxillary sinus cyst drug combination, it provide innovative approach for non-surgical treatment of maxillary bone cyst. Methods: 12 patients with maxillary sinus cyst were selected, all cases were confirmed by the jaw of surface fault CT or MRI examination, disinfection of double flank cheek skin and oral vestibular mucosa, after local anesthesia or surface anesthesia all patients with nasal endoscopic examination of the nasal passages, were punctured into maxillary sinus cyst from inferior nasal meatus, the needle core was removed, the cyst fluid was taken out by cannula, then through cannula place the right amount of maxillary sinus cyst drug composition were injected. The bases were iodine and dexamethasone solution with 2:1 injection (i.e., take out 2 ml cyst fluid, inject of 1 ml drugs, and so on). As routine is not easy to puncture biopsy in place of the cyst, image guided puncture was choosen. Results: 12 patients with maxillary sinus cyst came back to the hospital for a check of sinus CT after treatment of 1 to 3 months, the results are excellent, and 1 to 2 years follow-up were carried on, the follow-up of 11 cases, 1 case was lost of follow-up. During follow-up of patients, before treatment with clinical symptoms caused by maxillary sinus cyst, symptoms disappeared after treatment, the sinus CT showed cyst disappear significantly. Conclusion: The curative effect of maxillary bone cyst by maxillary sinus cyst drug combination is definite, it is landmark in the non-surgical treatment for maxillary bone cyst.

Objective: To study effect of JiangTangFangLong prescription on Serum hypersensitive c-reactive protein(hs-CRP), Ankle arm index(ABI) in patients with different syndrome types of diabetes deafness. Method: The change of hs-CRP and ABI was tested before and after treatment in 42 cases (84 ears) of different syndrome types of diabetes deafness treated with JiangTangFangLong prescription. Compared with 40 normal people. Result: Different syndrome patients before treatment compared with normal, hs-CRP increased significantly (P0.05). Gas Yin deficiency and Yin and Yang deficiency compared with nomal person and before and after treatment have statistical significance. Hs-CRP has increased and ABI has fallen(P

Objective:To observe the nasal resistance after medical combination treatments of maxillary cyst. Methods: 12 patients with maxillary cyst were selected, all cases were confirmed by sinus CT or MRI examination, disinfect both cheek's skin and oral vestibular mucosa. Operation should be taken under topical anesthesia or surface anesthesia, check the cases' nasal passages with transanal endoscopic microsurgery, withdraw the cyst fluid with a injector form the top flank of the nose. Then inject the drug of maxillary cyst(which mainly contains iodine and hexadecadro solution)with a proportion of 2:1(i.e., take out 2 ml cyst fluid, inject of 1 ml drugs, and so on). Cyst if can not be normally punctured can undertake the surgery with the assistance of image recorder. We should check the patients' nasal airway resistance (NAR), nasal volumes(NV), and minimalcross. Sectional area(MCA) using Eccovision Acoustic Rhinometer (HoodLabs, USA) and Anterior Rhinometer both before and after the treatments. Then deal the data with a computer. Results: 12 patients with maxillary sinus cyst came back to the hospital for a check of sinus CT check after treatment, compared with the data before the treatment, there are visible differences in general R(cmH20/LMi),general NV(cc) and MCA(cm2). (p

Objective: To observe the influence of Panax Notoginseng Saponins and tripterygium glycosides on the TNF, IL-6, PAI-1 level in CIA rat peripheral blood and the MCP-1 expression in myocardium. Methods: randomly dividing the successfully copied CIA rats into model, TG(10mg/Kg.d), PNS(200mg/Kg.d)+TG(10mg/Kg.d), MTX(1.6mg/Kg.w) group and Control group was set. Drawing blood after a six-week administration, opening the chest to take out the heart. The liquid phase protein chip technology was used to detect the content of serum TNF, IL-6, PAI-1, and immunohistochemical method to detect the myocardial MCP-1 protein expression. Results: Compared with the control group, the rat serum TNF, IL-6, PAI-1 level in CIA model group is obviously increased, the myocardial MCP-1 protein expression is significantly up-regulated, TG and PNS can obviously reduce the TNF, IL-6, PAI-1 level in serum, improve the pathological state of myocardium, and down-regulate the expression of MCP-1 in myocardium, and its effect is significantly better than that of TG and MTX group. Conclusions: the effective components of Chinese herbal medicine TG combined with PNS has a significant role in the prevention and treatment of cardiovascular injury, its mechanism may be related to reducing serum TNF, IL-6, PAI-1 and MCP-1 expression in myocardium to exert anti-inflammatory effect.

Objective: To understand the research hotspots of Ventricular Remodeling by PubMed. Methods: With MS Excel, SPSS, Cytoscape software, we took MeSH (Medical Subject Headings) word frequency analysis, clustering analysis, co-word network graph of PubMed papers. Results: By MeSH of 8231 papers analyzed, it shows that the current Ventricular Remodeling research hotspots had focused on "Myocardial Infarction, Heart Failure, Myocardium, Ventricular Dysfunction, Left, Ventricular Function, Left, Heart Ventricles", etc, it also suggests that the most importance of which was Myocardial Infarction. Conclusion: With multi-angle analysis of bibliometrics, we understand the outline of research hotspots about Ventricular Remodeling. It is helpful and time saving for the researcher or doctor to understand the research hotspots in Ventricular Remodeling.

Considering the present backward situation of the compressor splitter designing level, a multi-objective Combinatorial Optimization Design method is put forward for the splitter design consisting of three core components: the CST parameterized method, the Design of Experiment and the ASA optimization algorithm. In the whole optimization design process, the CST parameterized method is developed for the complex geometry modeling and geometric samples generating of splitter. The Design of Experiment is taken used to qualitatively analyze the multiple design variables and adjust their number and scopes. The ASA algorithm takes charge of the global optimization of splitter geometry samples, and selects the best geometry conform to the design target. All the relevant optimization components and modules are integrated by the Isight software and be interacted and automatically called by the edited scripts. The effectiveness of the proposed design method is verified through a practical splitter example. Results show that: 1) the CST parameterized method of fourth order or above is of great accurately to fit the splitter geometry, in order to generate variable geometric samples. 2) The Design of Experiment is able to identify the different influence of multiple design variables on the design objectives and lead to the optimization process more targeted. 3) The performance of optimization result is improved significantly, in which the core duct behaves more sensitive to splitter geometry changing and the low-static pressure and high-radial velocity areas reduced to half of the initial design.Copyright © 2015 by ASME

The traditional calculation method of industrial boiler thermal efficiency needs to input many parameters, which leads to a lot of complicated calculations. It is not suitable to make an accurate judgement on the operating condition of an industrial boiler, especially a wood pellets-fired one. In order to solve this problem, the paper presents a simplified mathematical model to calculate the thermal efficiency of a wood pellets-fired industrial boiler on-line by using an error analysis method. More concretely speaking, first, based on the results of the error analysis of an industrial boiler thermal efficiency, main factors that affect the thermal efficiency of a wood pellets-fired industrial boiler are obtained. Then, a simplified mathematical model to calculate the thermal efficiency of the wood pellets-fired industrial boiler is developed in terms of the major factors. Finally, the calculating results of the industrial boiler thermal efficiency based on the model are compared with the test values given by Guangdong Special Equipment Inspection and Research Institute and the maximum deviation limits within 3%. Therefore, it can be concluded that the simplified mathematical model proposed in this paper for calculating the thermal efficiency of the wood pellets-fired industrial boiler is proved to be practical, applicable and worth popularizing.

Objective To investigate the effect of T lymphocytes PD-1/B7-H1 path expression in patients with severe hepatitis depression from promoting liver cell growth hormone combinations from Gongying Yinchen soup. Methods With reference to the American psychiatric association’s diagnostic statistical manual of mental disorders, fourth edition (dsm-iv) criteria, 88 cases of fulminant hepatitis in patients with depression were collected as treatment group, which consist of acute severe hepatitis (n = 31), chronic severe hepatitis (n = 28) and subacute severe hepatitis (n = 29),120 mg promoting liver cell growth hormone to join within 250 ml of 10 % glucose injection, intravenous drip, 1 times a day, 15 d for a period of treatment, At the same time to add with the Gongying Yinchen soup (dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter arguments). Three period of treatment. Thirty healthy persons of control group come from blood donor of central blood stations. The expressions of PD-1/B7-H1 of T lymphocytes and T lymphocyte subsets of two groups were determined by flow cytometry. Results The positive expression of PD1 and B7—H1of T lymphocytes in patients of the treatment group was significant higher than that in healthy control group (P < 0.05); The positive expression of PD1and B7—H1of T lymphocytes significantly decreased after treatment in the treatment group (P < 0.05). The amount of CD4+, CD8+ cells of the treatment group was significantly lower than that of control group (P < 0.05). The amount of CD4+/CD8+ cells of the treatment group was higher than that of control group (P < 0.05), significantly decreased after treatment (P < 0.05). Conclusion Promoting liver cell growth hormone combination from the Gongying Yinchen soup can influence expression of T lymphocytes PD-1/B7-H1 path in patients with severe hepatitis depression, enhance the body’s immune response.

Objective Discuss the effect of using Hepatocyte growth-promoting factors combined with Gongying Yinchen soup to cure depression in patients with fulminant hepatitis. Methods Choose 61 cases of fulminant hepatitis patients with depression, With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, 31 cases patients were randomly divided into treatment group, which was given Gongying Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment and 30 in the control group, application of this method at the same time added nutgrass galingale rhizome, radix curcumae, radix angelicae sinensis, radix paeoniae alba, radix aucklandiae and other drugs. After three courses of treatment, HAMD rating scale, scores of TCM symptoms. Determine the efficacy. Results Use Gongying Yinchen soup combined with promoting liver cell growth hormone treatment of severe hepatitis patients with depression after treatment, pretherapy and post-treatment in the two groups of HAMD scale total score, treatment group before treatment 45.23 ± 17.29, after the treatment 44.25 ± 18.14; the control group before treatment 43.25 ± 18.30, after the treatment 28.46 ± 14.08, the therapeutic effect of control group patients was much better than that of treatment group cases (P < 0.05); Chinese medicine symptom curative effect as a whole,Treatment group total effectiveness 80.6 %, control group 93.3 %, had significant statistical differences were compared (P < 0.05). Conclusions Promoting liver cell growth to combination the Gongying Yinchen soup curative effect in patients with severe hepatitis depression significantly.

The papers about Hepatitis in Pubmed were retrieved, and Medical Subject Headings (MeSH) in retrieved papers were analyzed (word frequency analysis, clustering analysis, co-word network graph), it suggested that the current Hepatitis receptor research focus had focus on Programmed Cell Death Receptor, Tumor Necrosis Factor Receptor, Interleukin Receptor, also the most important of which was the Programmed Cell Death Receptor, the current hypertension ligand research focus had focus on making Antiviral Agents (Interferon-alpha) by Recombinant Proteins.

Objective Discuss the effect of Hepatocyte growth-promoting factors combined with Gongying Yinchen soup on peripheral blood SIL-2R of depression in fulminant hepatitis patients. Methods Choose 88 cases of fulminant hepatitis patients with depression,With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, The treatment group 88 cases, which was given GongYing Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment, Application of above methods at the same time to add with the Gongying Yinchen soup, etc. (Dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter ginseng). After the treatment for three courses, Peripheral blood levels of SIL-2R in all patients with severe hepatitis depression were detected,and 30 healthy blood donors were used as controls. Methods Adopt the method of ELISA for levels of SIL-2R in all patients of two groups were detected pre and post-treatment. Results Compare the blood level of SIL-2R of Each group patients with severe hepatitis and health adults, there is significant statistical significance (P < 0.05, P < 0.05). Treatment group after treatment level of serum SIL-2R significantly decreased, There was a significant difference in comparison with the pretreatment (P < 0.01). Conclusions Hepatocyte growth-promoting factors combined with Gongying Yinchen soup can influence peripheral blood SIL-2R of depression in fulminant hepatitis patients, efficacy significantly on severe hepatitis, Can enhance the body’s immune response.

The papers about hypertension in Pubmed were retrieved, and Medical Subject Headings (MeSH) in retrieved papers were analyzed (word frequency analysis, clustering analysis, co-word network graph), it suggested that the current hypertension treatment research hotspots had focus on angiotensin, vasodilator agent, calcium channel blockers, etc., also the most importance of which was the angiotensin.

Objective to study the chronic suppurative otitis media relations with bacterial infection and drug sensitivity test of Er yannig. Methods 55 cases of different type according to the regulation method of ear cavity samples of patients with chronic suppurative otitis media, test their anaerobic bacteria, aerobic bacteria respectively, and at the same time observe ear drug sensitive test. Results 55 pathogens of chronic suppurative otitis media patients 52 strains, including aerobic bacterium infection nine strains, accounting for 36.5 %. 18 strains of anaerobic bacteria infection accounted for 34.6 %, mixed aerobic and anaerobic bacteria infection 15 strains, accounting for 28.8 %; Er yanning drug sensitive test, the bacteriostasis of aerobic bacteria rate was 67.7–94.4 %, is sensitive to all anaerobic bacteria. Conclusion chronic suppurative otitis media by anaerobic bacteria and aerobic bacteria mixed infection, Er yanning has a dual antibacterial effect.

ObjectiveTo study the influence of Jiang Tang Fang Long formula on insulin production and function in an animal model of diabetic hearing loss.MethodsWistar rats (n=60) were randomly divided into 6 groups (10 in each) to receive no treatment (the normal control, Group A), or to receive intra-peritoneal 55 mg/kg streptozotocin with (Groups C, D and E) or without (Group B) subsequent Jiang Tang Fang Long formula treatment at various doses or Yu Long Wan treatment (Group F). After 60 days, fasting blood glucose (FBG), body weight (BW) and fasting insulin (FINS) were recorded and the HOMA-IR and HOMA-β calculated. Insulin expression in pancreatic tissues was measured by radioimmunoassay.ResultsCompared with animals that received streptozotocin without rescue treatment (Group B), animals that received higher doses of Jiang Tang Fang Long formula(Groups D and E) showed improved indices of diabetes manifestation (P< 0.05) and improved HOMA-β (P0.05).ConclusionOur results suggest that Jiang Tang Fang Long formula may improve pancreatic β-cells function which may explain its efficacy in treating diabetic hearing loss.