1. Detection of squamous cell carcinoma antigen with two systems in the follow-up of patients with cervical cancer
- Author
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Cristian Mauro, Davide Radice, Paola Lentati, Fabio Landoni, Maria Teresa Sandri, Laura Zorzino, Sara Boveri, Michela Salvatici, Maria Angela Massaro, Sandri, M, Salvatici, M, Mauro, C, Radice, D, Lentati, P, Massaro, M, Boveri, S, Zorzino, L, and Landoni, F
- Subjects
Male ,030213 general clinical medicine ,Cancer Research ,medicine.medical_specialty ,Clinical Biochemistry ,Uterine Cervical Neoplasms ,030204 cardiovascular system & hematology ,Squamous cell carcinoma Antigen ,Follow-Up Studie ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Antigens, Neoplasm ,Carcinoma ,Biomarkers, Tumor ,Medicine ,Humans ,Tumor marker ,Prospective Studies ,Squamous cell carcinoma antigen ,Prospective cohort study ,Serpins ,Serpin ,Cervical cancer ,Gynecology ,Methods comparison ,business.industry ,Follow up studies ,Middle Aged ,medicine.disease ,Prospective Studie ,Oncology ,Method comparison ,Carcinoma, Squamous Cell ,Female ,Antigens neoplasm ,business ,Nuclear medicine ,Human ,Follow-Up Studies - Abstract
Since squamous cell carcinoma antigen (SCC-Ag) testing became commercially available on the Architect platform, the previously established method on the Abbott IMx platform has been progressively replaced. Aim of this work was to compare SCC-Ag values obtained with the 2 methods. Clinical and laboratory data of 188 patients for whom SCC-Ag determination was requested, were reviewed. IMx was used to determine the levels of SCC-Ag from June 2007 to May 2009, while the Architect system was used from June 2009 to April 2011. Only patients consistently diagnosed with no evidence of disease, for whom at least 2 determinations with each analyzer were available were used. Comparison of the results obtained with the 2 systems was then performed. Mean values for SCC-Ag were 0.56 ng/mL (Standard Error (SE): 0.08) with the IMx method, and 1.08 ng/mL (SE 0.10) with Architect (p
- Published
- 2013