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Sun-Young Kim,1 Mi Hyun Lee,2 Weon-Jeong Lim,1 Soo In Kim,3 Yu Jin Lee2 1Department of Psychiatry, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; 2Department of Psychiatry and Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul University College of Medicine, Seoul, Republic of Korea; 3Department of Psychiatry, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of KoreaCorrespondence: Yu Jin LeeDepartment of Psychiatry and Center for Sleep and Chronobiology, Seoul National University Hospital, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, Seoul 03080, Republic of KoreaTel +82-2-2072-2456Fax +82-2-744-7241Email ewpsyche@snu.ac.krPurpose: The mean sleep duration of Koreans is 7 hours 49 minutes, which is the lowest among Organization for Economic Cooperation and Development countries. Although vitamin D deficiency and arthritis are considered modifiable factors influencing restorative sleep, mean vitamin D levels are low (17.33 ng/mL) and arthritis is prevalent among Koreans. This study investigated whether vitamin D deficiency and arthritis increase the risk of short sleep duration.Patients and Methods: The current study used data from the Korean National Health and Nutrition Examination Survey (KNHANES) for 46,405 Korean adults. Vitamin D levels were measured using a radioimmunoassay kit. Sleep duration and arthritis history were assessed using a self-reported questionnaire. Sleep duration was categorized as optimal (7 to < 9 hours/day), short (< 7 hours/day), and long (≥ 9 hours/day). Vitamin D levels were grouped as vitamin D sufficiency (≥ 20 ng/mL), insufficiency (10– 19.99 ng/mL), and deficiency (< 10 ng/mL). Multiple imputation was used to compensate for missing data. Multinomial logistic regression was used to examine the associations of vitamin D and arthritis status with sleep duration. The regressions were adjusted for covariates, and each model was adjusted for vitamin D and arthritis.Results: Among these participants, 23,078 (49.73%) and 3518 (7.58%) had short and long sleep duration, respectively; 26,724 (57.59%) and 4349 (9.37%) exhibited vitamin D insufficiency and deficiency, respectively; and 4709 (10.15%) were arthritis patients. Compared with vitamin D sufficiency, vitamin D insufficiency and deficiency were associated with short sleep duration (vitamin D insufficiency group: OR = 1.07, 95% CI = 1.01– 1.13; vitamin D deficiency group: OR = 1.13, 95% CI = 1.03– 1.24). The presence of arthritis was associated with short sleep duration (OR = 1.14, 95% CI = 1.06– 1.22) compared with its absence. The interaction between vitamin D deficiency and the presence of arthritis was significantly associated with short sleep duration. However, long sleep duration was not significantly associated with vitamin D levels or arthritis status.Conclusion: Low vitamin D levels and the presence of arthritis were associated with an increased risk of short sleep duration. Additionally, there was a positive interaction effect between vitamin D deficiency and arthritis on short sleep duration.Keywords: vitamin D, arthritis, sleep duration, Korean National Health and Nutrition Examination Survey, KNHANES

Leaching behaviors and mechanisms of commercialized glass wasteforms to sequester low-level solid-wastes were investigated: SG glass for resin waste and DG-2 glass for dry active waste. After ANS 16.1 leaching test, leachabilities of the nuclides, Co, Cs, and Sr, were all lager than 14, which met the requirement of the US-Nuclear Regulatory Commission. Holes of diameters 5–10 μm remained on the surface of the SG and crevices of lengths 10–50 μm were observed on the surface of the DG-2. We analyzed elemental compositions of the SG and the DG-2 with depths. For the SG, Si, Al, Ca, and Mg were accumulated and Na was depleted up to nearly 1.5 μm compared to an internal glass. For the DG-2, concentrations of B, Na, Al, Ca and Sr started to decrease from 2.5 μm even though other minor elements are still remained their concentrations. We suggested leaching mechanisms: alkali elements including H would diffuse through the holes on the SG, while most of the elements including Si and Al would diffuse through the crevices on the DG-2.

Sugars play important roles in many aspects of plant growth and development, acting as both energy sources and signaling molecules. With the successful use of genetic approaches, the molecular components involved in sugar signaling have been identified and their regulatory roles in the pathways have been elucidated. Here, we describe novel mutants of Arabidopsis (Arabidopsis thaliana), named glucose insensitive growth (gig), identified by their insensitivity to high-glucose (Glc)-induced growth inhibition. The gig mutant displayed retarded growth under normal growth conditions and also showed alterations in the expression of Glc-responsive genes under high-Glc conditions. Our molecular identification reveals that GIG encodes the plastidial copper (Cu) transporter PAA1 (for P(1B)-type ATPase 1). Interestingly, double mutant analysis indicated that in high Glc, gig is epistatic to both hexokinase1 (hxk1) and aba insensitive4 (abi4), major regulators in sugar and retrograde signaling. Under high-Glc conditions, the addition of Cu had no effect on the recovery of gig/paa1 to the wild type, whereas exogenous Cu feeding could suppress its phenotype under normal growth conditions. The expression of GIG/PAA1 was also altered by mutations in the nuclear factors HXK1, ABI3, and ABI4 in high Glc. Furthermore, a transient expression assay revealed the interaction between ABI4 and the GIG/PAA1 promoter, suggesting that ABI4 actively regulates the transcription of GIG/PAA1, likely binding to the CCAC/ACGT core element of the GIG/PAA1 promoter. Our findings indicate that the plastidial Cu transporter PAA1, which is essential for plastid function and/or activity, plays an important role in bidirectional communication between the plastid and the nucleus in high Glc.

In Bayesian inference, the choice of prior has been of great interest. Subjective priors are ideal if sufficient information on priors is available. However, in practice, we cannot collect enough information on priors. Then objective priors are a good substitute for subjective priors. In this dissertation, an independent reference prior based on a class of objective priors is examined. It is a reference prior derived by assuming that the parameters are independent. The independent reference prior introduced by Sun and Berger (1998) is extended and generalized. We provide an iterative algorithm to derive the general independent reference prior. We also propose a sufficient condition under which a closed form of the independent reference prior is derived without going through the iterations in the iterative algorithm. The independent reference prior is then shown to be useful in respect of the invariance and the first order matching property. It is proven that the independent reference prior is invariant under a type of one-to-one transformation of the parameters. It is also seen that the independent reference prior is a first order probability matching prior under a sufficient condition. We derive the independent reference priors for various examples. It is observed that they are first order matching priors and the reference priors in most of the examples. We also study an independent reference prior in some types of non-regular cases considered by Ghosal (1997). Ph. D.