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4 results on '"Lederlin M"'

1. Pulmonary manifestations induced by osimertinib

Author

Le Guen, Y, Lederlin, M, Triquet, L, Lesouhaitier, M, Le Tulzo, Y, Ricordel, C, CHU Pontchaillou [Rennes], Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CRLCC Eugène Marquis (CRLCC)

Subjects
Pulmonary and Respiratory Medicine, 0303 health sciences, Pneumopathie interstitielle, Adverse drug reactions, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, respiratory tract diseases, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Effets secondaires indésirables des médicaments, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cancer bronchique, Lung cancer, Osimertinib, Interstitial pneumonia, 030304 developmental biology
Abstract

National audience; INTRODUCTION: The third-generation tyrosine kinase inhibitor (TKI) osimertinib is recommended as a first-line treatment in advanced non-small cell lung cancer harboring an activating mutation of Epidermal Growth Factor Receptor (EGFR). Adverse pulmonary events related to osimertinib exposure have been reported, primarily in Japanese patients. They rarely occur in the Caucasian population. OBSERVATION: Herein we report two clinical cases of osimertinib-induced lung toxicities in patients diagnosed with advanced lung adenocarcinoma harboring an EGFR mutation. In the first case, interstitial pneumonia was asymptomatic and evolved favorably after osimertinib discontinuation. The second patient presented a more extensive form of lung injuries and despite systemic corticosteroid therapy, the evolution was fatal. CONCLUSION: Osimertinib-related lung toxicities remain exceptional. While most forms are mild, consideration of TKI treatment discontinuation may be necessitated. Introduction of another TKI or rechallenge with osimertinib might be considered along with corticosteroid therapy if necessary. Diffuse alveolar damage is a pejorative prognostic factor.

Published
2022
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2. Target definition for cardiac radioablation of ventricular tachycardia: A multimodal workflow

Author

Rigal, L., Martins, R., Benali, K., Bellec, J., Lederlin, M., de Crevoisier, R., Simon, A., Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), CHU Pontchaillou [Rennes], and Jonchère, Laurent

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, [SDV.IB]Life Sciences [q-bio]/Bioengineering
Abstract

International audience; Meeting Abstract PO-1622

Published
2022

3. [Ambulatory management of bilateral secondary spontaneous pneumothorax in palliative care]

Author

Chauvin, P, Sohier, L, Rochas, Y, Kerjouan, M, Salé, A, Lederlin, M, Jouneau, S, CHU Pontchaillou [Rennes], Groupe Hospitalier Bretagne Sud (GHBS), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV]Life Sciences [q-bio], Soins ambulatoires, Pneumothorax, Pneumothorax spontané, Middle Aged, Metastases, Treatment Outcome, Chest tubes, Outpatient care, Drains thoraciques, Ambulatory Care, Palliative care, Soins palliatifs, Humans, Female, Spontaneous pneumothorax, Neoplasm Recurrence, Local, Métastases, Retrospective Studies
Abstract

National audience; INTRODUCTION: Secondary spontaneous pneumothoraces account for 35% of all pneumothoraces after the age of 50. Their management is still debated and can be challenging due to the underlying respiratory condition. In our observation, the use of small-bore chest tubes allowed prolonged ambulatory care in a palliative setting. CASE REPORT: We report the case of a 54-year-old woman suffering from a leiomyosarcoma with multiple pulmonary metastases who had repeated episodes of pneumothorax, one of which was bilateral. Treatment involved the bilateral insertion of 8.5F pigtail catheters connected to Heimlich valves that allowed management as an outpatient. Recurrences were treated similarly, in association with oncological management, providing great additional benefits for patient comfort in this palliative context. CONCLUSION: Altogether, this case report confirms the applicability of outpatient management for drained spontaneous secondary pneumothoraces, even bilateral, especially in a palliative-care setting.

Published
2021
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4. EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation

Author

Donal, Erwan, Lip, Gregory Y H, Galderisi, Maurizio, Goette, Andreas, Shah, Dipen, Marwan, Mohamed, Lederlin, Mathieu, Mondillo, Sergio, Edvardsen, Thor, Sitges, Marta, Grapsa, Julia, Garbi, Madalina, Senior, Roxy, Gimelli, Alessia, Potpara, Tatjana S, Van Gelder, Isabelle C, Gorenek, Bulent, Mabo, Philippe, Lancellotti, Patrizio, Kuck, Karl-Heinz, Popescu, Bogdan A, Hindricks, Gerhard, Habib, Gilbert, Cardim, Nuno M, Cosyns, Bernard, Delgado, Victoria, Haugaa, Kristina H, Muraru, Denisa, Nieman, Koen, Boriani, Giuseppe, Cohen, Ariel, Clinical sciences, Cardio-vascular diseases, Cardiology, CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Naples Federico II = Università degli studi di Napoli Federico II, Cardiology Department, Thorax Clinic Institute, Hospital Cliınic, Institut d'Investigacions Biomèdiques [Barcelona], Universitat de Barcelona (UB), Imperial College London, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Donal, E, Lip, G, Galderisi, M, Goette, A, Shah, D, Marwan, M, Lederlin, M, Mondillo, S, Edvardsen, T, Sitges, M, Grapsa, J, Garbi, M, Senior, R, Gimelli, A, Potpara, T, Van Gelder, I, Gorenek, B, Mabo, P, Lancellotti, P, Kuck, K, Popescu, B, Hindricks, G, Habib, Document Reviewers: Cardim NM, G, Cosyns, B, Delgado, V, Haugaa, K, Muraru, D, Nieman, K, Boriani, G, Cohen, A, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Napoli Federico II, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Donal, Erwan, Lip, Gregory Y. H, Galderisi, Maurizio, Goette, Andrea, Shah, Dipen, Marwan, Mohamed, Lederlin, Mathieu, Mondillo, Sergio, Edvardsen, Thor, Sitges, Marta, Grapsa, Julia, Garbi, Madalina, Senior, Roxy, Gimelli, Alessia, Potpara, Tatjana S, Van Gelder, Isabelle C, Gorenek, Bulent, Mabo, Philippe, Lancellotti, Patrizio, Kuck, Karl Heinz, Popescu, Bogdan A, Hindricks, Gerhard, and Habib, Gilbert

Subjects
Cardiac magnetic resonance, RIGHT-VENTRICULAR FUNCTION, Speckle tracking echocardiography, Computed tomography, 030204 cardiovascular system & hematology, Doppler echocardiography, Multimodal Imaging, 0302 clinical medicine, Nuclear Medicine and Imaging, RADIOFREQUENCY CATHETER ABLATION, 030212 general & internal medicine, Cardiac imaging, ddc:616, SPONTANEOUS ECHOCARDIOGRAPHIC CONTRAST, medicine.diagnostic_test, CARDIAC MAGNETIC-RESONANCE, Atrial fibrillation, General Medicine, Atrial Fibrillation/diagnostic imaging/epidemiology/physiopathology, Pathophysiology, Atrial Fibrillation, Consensus, Europe, Humans, Practice Guidelines as Topic, Radiology, Nuclear Medicine and Imaging, Cardiology and Cardiovascular Medicine, 3. Good health, MULTISLICE COMPUTED-TOMOGRAPHY, Cardiology, cardiovascular system, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Atrial Fibrillation/diagnostic imaging, Radiology, Human, TIME 3-DIMENSIONAL ECHOCARDIOGRAPHY, medicine.medical_specialty, SPECKLE-TRACKING ECHOCARDIOGRAPHY, SPONTANEOUS ECHO CONTRAST, Consensu, Multi modality, 03 medical and health sciences, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business.industry, HEART RHYTHM ASSOCIATION, Expert consensus, medicine.disease, APPENDAGE CLOSURE DEVICE, business
Abstract

International audience; Atrial fibrillation (AF) is the commonest cardiac rhythm disorder. Evaluation of patients with AF requires an electrocardiogram, but imaging techniques should be considered for defining management and driving treatment. The present document is an expert consensus from the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association. The clinical value of echocardiography, cardiac magnetic resonance (CMR), computed tomography (CT), and nuclear imaging in AF patients are challenged. Left atrial (LA) volume and strain in echocardiography as well as assessment of LA fibrosis in CMR are discussed. The value of CT, especially in planning interventions, is highlighted. Fourteen consensus statements have been reached. These may serve as a guide for both imagers and electrophysiologists for best selecting the imaging technique and for best interpreting its results in AF patients

Published
2016
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