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Lipopolysaccharide (LPS) is a constituent of Gram-negative bacterial cell walls, thus LPS injection has been widely used as a model of experimental acute kidney injury associated with sepsis. LPS-induced sepsis is caused by excessive secretion of proinflammatory mediators and reactive oxygen species (ROS). The neurohormone melatonin, which is mainly secreted by the pineal gland, regulates the circadian rhythm, has an anti-inflammatory and immunoregulatory role. Melatonin and its metabolites have been shown to scavenge various free radicals and reactive oxygen intermediates. The aim of this study was to evaluate the effect of melatonin in preventing endotoxemia-induced kidney damage caused by LPS, by analysing the concentration of urea and creatinine in the blood serum of rats. Twenty-eight Wistar albino rats were randomly divided into four groups (n = 7 per group) as follows: 1) Control group, 2) MLT group (50 mg/kg, per os), 3) LPS group (10 mg/kg, i.p.) and 4) LPS + MLT group (10 mg/kg + 50 mg/kg). Serum levels of creatinine and urea were significantly higher (p

Although surgical revascularization of the myocardium is routine and one of the most performed procedures in cardiac surgery, complications that occur during and after surgery, such as systemic inflammation and sepsis, as well as bleeding due to impaired platelet function, have a high share in such high mortality. The extracorporeal bloodstream system has a special role in these processes. Determination of levels of new biomarker for detection infectious complications - presepsin, with CRP and leukocyte formula, is just one of these diagnostic combinations of tests that allow assessment of the immune status of a cardiac patient and the need for further examination and / or therapy of patients who may potentially develop systemic inflammatory response syndrome (SIRS) or sepsis. On the other hand, the application of aggregometry gives precise data on the functional changes of platelets, which enables adequate care of complications in terms of increased postoperative bleeding or thrombosis. The study included 100 patients of both sexes, 22 women (21.6%) and 78 men (76.5%), mean age 64.63 ± 7.48 years. Patients were divided into two groups in relation to the use of extracorporeal blood circulation device. Postoperatively, there was a decrease in the number of erythrocytes (p 1800ml) was present in 15 patients (15 in the group where the extracorporeal circulatory system was applied, 17.64% of patients (9/51) met the clinical criteria for SIRS with elevated presepsin values of 600 pg / ml and more, while in the second group of patients 2 of 49 (4.08%) met the clinical and laboratory criteria for SIRS.The ECC system significantly affects the development of SIRS and inhibition of platelet function in patients where it was applied during surgery.

Неједнакости Коши-Шварца и Грис-Ландауа за елементарне операторе и трансформере типа унутрашњег производа на Q и Q∗ идеалима компактних оператора Резиме: Листа од раније познатих и недавно установљених Cauchy-Schwarz-ових неједнакости за елементарне операторе, σ−елементарне трансформере и трансформере типа унутрашњег производа допуњена је следећом варијантом Cauchy-Schwarz-ове неједнакости у Schatten-von Neumann-овим идеалима: ZΩ AtA∗ t dµ(t) 12q − 1Z2 Ω AtXBt dµ(t)ZΩ Bt∗Bt dµ(t) 1 2r − 12 p 6 ZΩ A∗ t At dµ(t) 12q XZΩ BtBt∗ dµ(t) 1 2r p за све X 2 C p(H) и све p, q, r > 1 такве да је 2 p = 1q + 1r, уколико су фамилије оператора fAtgt∈Ω, fA∗ tgt∈Ω, fBtgt∈Ω, fBt∗gt∈Ω јако квадратно интеграбилне, такве да су RΩ AtA∗ t dµ(t) и RΩ Bt∗Bt dµ(t) (ограничено) инвертибилни оператори. Разматраће се такође и друге варијанте оваквих неједнакости, омогућене додатним условима комутативности и нормалности операторних фамилија fAng∞ n=1, fBng∞ n=1, fAtgt∈Ω и fBtgt∈Ω, односно степеном p-модификације унитарно инваријантних норми, као и примене ових неједнакости на одређене проблеме у теорији оператора, укључујући норма неједнакости за генерализоване функцијске деривације Pick-ових оператор вредносних функција и оператор вредносних Fourier-ових трансформација комплексних мера, као и неједнакости Grüss-Landau-овог типа. List of already known and recently established Cauchy-Schwarz inequalities for elementary operators, σ−elementary transformers and inner product type transformers is complemented by the next variant of Cauchy-Schwarz inequality in Schatten-von Neumann ideals: ZΩ AtA∗ t dµ(t) 12q − 1Z2 Ω AtXBt dµ(t)ZΩ Bt∗Bt dµ(t) 1 2r − 12 p 6 ZΩ A∗ t At dµ(t) 12q XZΩ BtBt∗ dµ(t) 1 2r p for all X 2 C p(H) and for all p, q, r > 1 which satisfes 2 p = 1q + 1r, if families of operators fAtgt∈Ω, fA∗ tgt∈Ω, fBtgt∈Ω, fBt∗gt∈Ω are strongly square integrabile, such that RΩ AtA∗ t dµ(t) and RΩ Bt∗Bt dµ(t) are (boundedly) invertible operators. Enabled by some additional conditions of commutativity and normality for operator families fAng∞ n=1, fBng∞ n=1, fAtgt∈Ω and fBtgt∈Ω, as well as by the degree of p-modifcations of unitary invariant norms, some others variants of those inequalities will also be considered, including their applications to the certain problems in operator theory, norm inequalities for generalized function derivations of Pick operator values functions and operator values Fourier transformations of complex measures, as well as some Grüss-Landau type inequalities.

Financial benchmarking (BM) is a technique of advanced managing with a view to establishing differences in financial performances, the so called gaps, compared to the competition. It represents an integral part of the overall benchmarking process the use of which involves identification of the backlogs in relation with an entity that has the function of the reference value, with the aim to find ways to overcome them. The use of financial BM is illustrated on the example of Serbian banking industry. In this process, we applied the partitioning clustering (grouping) in order to form homogenous groups from which the leaders are selected for comparison. The analysis was done on the basis of ratios for the past five years (period 2010 - 2014), which, thus, covered spatial and temporal dimensions of comparison. Following the comparison of ratios in the banking industry and non-financial corporations, their adaptation was performed taking into account the particularities of banks' operations. The benefits arising from the use of financial BM process are shown, but also the limitations considering that many important indicators are not publicly available.

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Ovo džepno izdanje Protokola zbrinjavanja u hitnoj medicinskoj pomoći za medicinske sestre - medicinske tehničare, specijaliste hitne medicinske pomoći sačinjeno je kao podsjetnik i brzi vodič kroz najčešća hitna stanja i podrazumijeva da korisnik ima dodatnu specijalističku izobrazbu, trajnu edukaciju temeljenu na stručnim i znanstvenim programima, kao i konzultiranje dodatne stručne literature. U skladu s time Ministarstvo zdravstva i socijalne skrbi u suradnji s timom stručnjaka izradila je ovaj priručnik kao temelj pomoći svakoj medicinskoj sestri i medicinskim tehničarima na terenu koji svoj životni put vide u pružanju pomoći drugima te očuvanju života i zdravlja građanima Republike Hrvatske.