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This paper introduces InternVid, a large-scale video-centric multimodal dataset that enables learning powerful and transferable video-text representations for multimodal understanding and generation. The InternVid dataset contains over 7 million videos lasting nearly 760K hours, yielding 234M video clips accompanied by detailed descriptions of total 4.1B words. Our core contribution is to develop a scalable approach to autonomously build a high-quality video-text dataset with large language models (LLM), thereby showcasing its efficacy in learning video-language representation at scale. Specifically, we utilize a multi-scale approach to generate video-related descriptions. Furthermore, we introduce ViCLIP, a video-text representation learning model based on ViT-L. Learned on InternVid via contrastive learning, this model demonstrates leading zero-shot action recognition and competitive video retrieval performance. Beyond basic video understanding tasks like recognition and retrieval, our dataset and model have broad applications. They are particularly beneficial for generating interleaved video-text data for learning a video-centric dialogue system, advancing video-to-text and text-to-video generation research. These proposed resources provide a tool for researchers and practitioners interested in multimodal video understanding and generation., Data and Code: https://github.com/OpenGVLab/InternVideo/tree/main/Data/InternVid

Autophagy-related 4B (ATG4B) is a protease required for core machinery of autophagy. Phosphorylation of ATG4B promotes autophagy and is correlated with poor outcome of cancer. However, little is known about the upstream kinases for ATG4B phosphorylation and their association with clinical outcomes of cancer patients. Through siRNA library screening, MAP3K11 was identified as a potential kinase that phosphorylates ATG4B and increases its proteolytic activity. Ablation of MAP3K11 attenuated pS383/392-ATG4B protein levels and autophagic flux in oral cancer cells. Moreover, loss of MAP3K11 inhibited oral cancer cell growth, migration/invasion, and synergized starvation-reduced cell viability. MAP3K11 knock-out cancer cells also showed growth inhibition in vivo. Furthermore, the protein level of MAP3K11 was higher in tumor tissues than that in adjacent normal tissues in patients with oral squamous cell carcinoma (OSCC), comprising 179 buccal mucosa squamous cell carcinoma (BMSCC) and 249 tongue squamous cell carcinoma (TSCC). MAP3K11 protein levels were positively correlated with ATG4B and pS383/392-ATG4B levels in patients with OSCC, particularly in TSCC. In addition, high coexpression of MAP3K11 and ATG4B was associated with poor disease-specific survival in BMSCC and TSCC, while high coexpression of MAP3K11 and pS383/392-ATG4B was associated with unfavorable disease-free survival in BMSCC and TSCC. Taken together, our results indicated that MAP3K11 stimulated activity of ATG4B and autophagy, which may confer to malignancy of cancer cells. The expression of MAP3K11 and ATG4B was further associated with poor survival of OSCC, suggesting MAP3K11 could serve as a theranostic target of patients with OSCC.

Text-guided image generation has witnessed unprecedented progress due to the development of diffusion models. Beyond text and image, sound is a vital element within the sphere of human perception, offering vivid representations and naturally coinciding with corresponding scenes. Taking advantage of sound therefore presents a promising avenue for exploration within image generation research. However, the relationship between audio and image supervision remains significantly underdeveloped, and the scarcity of related, high-quality datasets brings further obstacles. In this paper, we propose a unified framework 'Align, Adapt, and Inject' (AAI) for sound-guided image generation, editing, and stylization. In particular, our method adapts input sound into a sound token, like an ordinary word, which can plug and play with existing powerful diffusion-based Text-to-Image (T2I) models. Specifically, we first train a multi-modal encoder to align audio representation with the pre-trained textual manifold and visual manifold, respectively. Then, we propose the audio adapter to adapt audio representation into an audio token enriched with specific semantics, which can be injected into a frozen T2I model flexibly. In this way, we are able to extract the dynamic information of varied sounds, while utilizing the formidable capability of existing T2I models to facilitate sound-guided image generation, editing, and stylization in a convenient and cost-effective manner. The experiment results confirm that our proposed AAI outperforms other text and sound-guided state-of-the-art methods. And our aligned multi-modal encoder is also competitive with other approaches in the audio-visual retrieval and audio-text retrieval tasks., Tech Report

Human driver can easily describe the complex traffic scene by visual system. Such an ability of precise perception is essential for driver's planning. To achieve this, a geometry-aware representation that quantizes the physical 3D scene into structured grid map with semantic labels per cell, termed as 3D Occupancy, would be desirable. Compared to the form of bounding box, a key insight behind occupancy is that it could capture the fine-grained details of critical obstacles in the scene, and thereby facilitate subsequent tasks. Prior or concurrent literature mainly concentrate on a single scene completion task, where we might argue that the potential of this occupancy representation might obsess broader impact. In this paper, we propose OccNet, a multi-view vision-centric pipeline with a cascade and temporal voxel decoder to reconstruct 3D occupancy. At the core of OccNet is a general occupancy embedding to represent 3D physical world. Such a descriptor could be applied towards a wide span of driving tasks, including detection, segmentation and planning. To validate the effectiveness of this new representation and our proposed algorithm, we propose OpenOcc, the first dense high-quality 3D occupancy benchmark built on top of nuScenes. Empirical experiments show that there are evident performance gain across multiple tasks, e.g., motion planning could witness a collision rate reduction by 15%-58%, demonstrating the superiority of our method., Project link: https://github.com/OpenDriveLab/OccNet

Text-to-image generation has recently witnessed remarkable achievements. We introduce a text-conditional image diffusion model, termed RAPHAEL, to generate highly artistic images, which accurately portray the text prompts, encompassing multiple nouns, adjectives, and verbs. This is achieved by stacking tens of mixture-of-experts (MoEs) layers, i.e., space-MoE and time-MoE layers, enabling billions of diffusion paths (routes) from the network input to the output. Each path intuitively functions as a "painter" for depicting a particular textual concept onto a specified image region at a diffusion timestep. Comprehensive experiments reveal that RAPHAEL outperforms recent cutting-edge models, such as Stable Diffusion, ERNIE-ViLG 2.0, DeepFloyd, and DALL-E 2, in terms of both image quality and aesthetic appeal. Firstly, RAPHAEL exhibits superior performance in switching images across diverse styles, such as Japanese comics, realism, cyberpunk, and ink illustration. Secondly, a single model with three billion parameters, trained on 1,000 A100 GPUs for two months, achieves a state-of-the-art zero-shot FID score of 6.61 on the COCO dataset. Furthermore, RAPHAEL significantly surpasses its counterparts in human evaluation on the ViLG-300 benchmark. We believe that RAPHAEL holds the potential to propel the frontiers of image generation research in both academia and industry, paving the way for future breakthroughs in this rapidly evolving field. More details can be found on a webpage: https://miaohua.sensetime.com/en., Project Page: https://miaohua.sensetime.com/en

This work introduces Video Diffusion Transformer (VDT), which pioneers the use of transformers in diffusion-based video generation. It features transformer blocks with modularized temporal and spatial attention modules, allowing separate optimization of each component and leveraging the rich spatial-temporal representation inherited from transformers. VDT offers several appealing benefits. 1) It excels at capturing temporal dependencies to produce temporally consistent video frames and even simulate the dynamics of 3D objects over time. 2) It enables flexible conditioning information through simple concatenation in the token space, effectively unifying video generation and prediction tasks. 3) Its modularized design facilitates a spatial-temporal decoupled training strategy, leading to improved efficiency. Extensive experiments on video generation, prediction, and dynamics modeling (i.e., physics-based QA) tasks have been conducted to demonstrate the effectiveness of VDT in various scenarios, including autonomous driving, human action, and physics-based simulation. We hope our study on the capabilities of transformer-based video diffusion in capturing accurate temporal dependencies, handling conditioning information, and achieving efficient training will benefit future research and advance the field. Codes and models are available at https://github.com/RERV/VDT.

In this study, we initiate an exploration into video understanding by introducing VideoChat, an end-to-end chat-centric video understanding system. It integrates video foundation models and large language models via a learnable neural interface, excelling in spatiotemporal reasoning, event localization, and causal relationship inference. To instructively tune this system, we propose a video-centric instruction dataset, composed of thousands of videos matched with detailed descriptions and conversations. This dataset emphasizes spatiotemporal reasoning and causal relationships, providing a valuable asset for training chat-centric video understanding systems. Preliminary qualitative experiments reveal our system's potential across a broad spectrum of video applications and set the standard for future research. Access our code and data at https://github.com/OpenGVLab/Ask-Anything, Technical report

We present an interactive visual framework named InternGPT, or iGPT for short. The framework integrates chatbots that have planning and reasoning capabilities, such as ChatGPT, with non-verbal instructions like pointing movements that enable users to directly manipulate images or videos on the screen. Pointing (including gestures, cursors, etc.) movements can provide more flexibility and precision in performing vision-centric tasks that require fine-grained control, editing, and generation of visual content. The name InternGPT stands for \textbf{inter}action, \textbf{n}onverbal, and \textbf{chat}bots. Different from existing interactive systems that rely on pure language, by incorporating pointing instructions, the proposed iGPT significantly improves the efficiency of communication between users and chatbots, as well as the accuracy of chatbots in vision-centric tasks, especially in complicated visual scenarios where the number of objects is greater than 2. Additionally, in iGPT, an auxiliary control mechanism is used to improve the control capability of LLM, and a large vision-language model termed Husky is fine-tuned for high-quality multi-modal dialogue (impressing ChatGPT-3.5-turbo with 93.89\% GPT-4 Quality). We hope this work can spark new ideas and directions for future interactive visual systems. Welcome to watch the code at https://github.com/OpenGVLab/InternGPT., Technical Report

Foundation models have achieved great advances in multi-task learning with a unified interface of unimodal and multimodal tasks. However, the potential of such multi-task learners has not been exploited during transfer learning. In this work, we present a universal parameter-efficient transfer learning method, termed Predict-Interpolate Tuning ($\pi$-Tuning), for vision, language, and vision-language tasks. It aggregates the parameters of lightweight task-specific experts learned from similar tasks to aid the target downstream task. The task similarities are predicted in a unified modality-independent space, yielding a scalable graph to demonstrate task relationships. $\pi$-Tuning has several appealing benefits. First, it flexibly explores both intra- and inter-modal transferability between similar tasks to improve the accuracy and robustness of transfer learning, especially in data-scarce scenarios. Second, it offers a systematical solution for transfer learning with multi-task prediction-and-then-interpolation, compatible with diverse types of parameter-efficient experts, such as prompt and adapter. Third, an extensive study of task-level mutual benefits on 14 unimodal and 6 multimodal datasets shows that $\pi$-Tuning surpasses fine-tuning and other parameter-efficient transfer learning methods both in full-shot and low-shot regimes. The task graph also enables an in-depth interpretable analysis of task transferability across modalities. The code will be available at https://github.com/TencentARC/pi-Tuning., Comment: To appear in ICML 2023

Safety is the primary priority of autonomous driving. Nevertheless, no published dataset currently supports the direct and explainable safety evaluation for autonomous driving. In this work, we propose DeepAccident, a large-scale dataset generated via a realistic simulator containing diverse accident scenarios that frequently occur in real-world driving. The proposed DeepAccident dataset contains 57K annotated frames and 285K annotated samples, approximately 7 times more than the large-scale nuScenes dataset with 40k annotated samples. In addition, we propose a new task, end-to-end motion and accident prediction, based on the proposed dataset, which can be used to directly evaluate the accident prediction ability for different autonomous driving algorithms. Furthermore, for each scenario, we set four vehicles along with one infrastructure to record data, thus providing diverse viewpoints for accident scenarios and enabling V2X (vehicle-to-everything) research on perception and prediction tasks. Finally, we present a baseline V2X model named V2XFormer that demonstrates superior performance for motion and accident prediction and 3D object detection compared to the single-vehicle model.

We present an extremely simple Ultra-Resolution Style Transfer framework, termed URST, to flexibly process arbitrary high-resolution images (e.g., 10000x10000 pixels) style transfer for the first time. Most of the existing state-of-the-art methods would fall short due to massive memory cost and small stroke size when processing ultra-high resolution images. URST completely avoids the memory problem caused by ultra-high resolution images by (1) dividing the image into small patches and (2) performing patch-wise style transfer with a novel Thumbnail Instance Normalization (TIN). Specifically, TIN can extract thumbnail features' normalization statistics and apply them to small patches, ensuring the style consistency among different patches. Overall, the URST framework has three merits compared to prior arts. (1) We divide input image into small patches and adopt TIN, successfully transferring image style with arbitrary high-resolution. (2) Experiments show that our URST surpasses existing SOTA methods on ultra-high resolution images benefiting from the effectiveness of the proposed stroke perceptual loss in enlarging the stroke size. (3) Our URST can be easily plugged into most existing style transfer methods and directly improve their performance even without training. Code is available at https://git.io/URST., Accepted to AAAI 2022

PDF file, 75K, Overexpression of CTMP enhances PI3K-mediated Akt phosphorylation.

Table S3: List of antibodies used in this study.

PDF file, 146K.

PDF file, 187K, The N-terminal domain, 1-64 a.a., of CTMP is required, but not sufficient, to induce Akt phosphorylation, colony formation and cell proliferation.

PDF file, 63K, Association of CTMP expression with prognosis of patients with different cancer type in 4 cohorts from Prognoscan database.

Table S2: Sequence of the oligonucleotides for shRNA, real-time PCR, and ChIP assay.

PDF file, 70K, PI3K inibitor blocked serum-induced Akt phosphorylation.

Table S1: Correlation of 5hmC, TET1 and TET3 with tumor hypoxia in 165 breast cancer cases.

We propose a simple, efficient, yet powerful framework for dense visual predictions based on the conditional diffusion pipeline. Our approach follows a "noise-to-map" generative paradigm for prediction by progressively removing noise from a random Gaussian distribution, guided by the image. The method, called DDP, efficiently extends the denoising diffusion process into the modern perception pipeline. Without task-specific design and architecture customization, DDP is easy to generalize to most dense prediction tasks, e.g., semantic segmentation and depth estimation. In addition, DDP shows attractive properties such as dynamic inference and uncertainty awareness, in contrast to previous single-step discriminative methods. We show top results on three representative tasks with six diverse benchmarks, without tricks, DDP achieves state-of-the-art or competitive performance on each task compared to the specialist counterparts. For example, semantic segmentation (83.9 mIoU on Cityscapes), BEV map segmentation (70.6 mIoU on nuScenes), and depth estimation (0.05 REL on KITTI). We hope that our approach will serve as a solid baseline and facilitate future research, Added controlnet exp

PDF file, 114K, CTMP mRNA expression data adapted from GEO public available microarray database, GSE3744.

Supplementary Figures S1-19 and legends. Figure S1: Overexpression of HIF-1α enhances BTIC characteristics. Figure S2: Characterizations of isolated BTICs by different parameters. Figure S3: The expression of TET1 and TET3 is upregulated by hypoxia. Figure S4: HIF-1α binding to TET1 and TET3 gene promoter in HIF-1α overexpressing cells. Figure S5: Knockdown of TET diminishes hypoxia induced activation of stemness related genes in breast cancer cell lines. Figure S6: Knockdown of TET1/3 represses tumorigenicity of isolated BTICs in vivo. Figure S7: Isotype control for IHC analysis. Figure S8: Gene specific changes in 5hmC level and TET proteins binding in hypoxic, HIF-1α overexpressing cells and isolated BTICs. Figure S9: Starvation is unable to affect the levels of 5hmC on the genome regions of TNFα gene and TNFα gene expression. Figure S10: TET proteins are essential for hypoxia activated TNFα-p38-MAPK signaling. Figure S11: TET proteins are required for hypoxia-induced 5hmC change on the genome regions of the TNFα gene. Figure S12: The enzymatic activity of TET proteins is required for establishing 5hmC signature upon hypoxia. Figure S13: The enzymatic activity of TET proteins is required for activation of TNFα-p38-MAPK signaling upon hypoxia. Figure S14: Protein-protein interaction between TET1 and TET3 in hypoxic cells and isolated BTICs. Figure S15: Co-occupancy of TET1 and TET3 on genome regions of the TNFα gene. Figure S16: Suppression of p38-MAPK signaling reduces BTIC properties. Figure S17: Certain downstream targets of TNFα-p38-MAPK signaling are regulated by hypoxia/TET. Figure S18: The levels of 5hmC and the bindings of TET proteins at pluripotent loci upon hypoxia. Figure S19: The landscape for 5hmC level and TET proteins binding on pluripotent loci upon hypoxia.

Controllable image denoising aims to generate clean samples with human perceptual priors and balance sharpness and smoothness. In traditional filter-based denoising methods, this can be easily achieved by adjusting the filtering strength. However, for NN (Neural Network)-based models, adjusting the final denoising strength requires performing network inference each time, making it almost impossible for real-time user interaction. In this paper, we introduce Real-time Controllable Denoising (RCD), the first deep image and video denoising pipeline that provides a fully controllable user interface to edit arbitrary denoising levels in real-time with only one-time network inference. Unlike existing controllable denoising methods that require multiple denoisers and training stages, RCD replaces the last output layer (which usually outputs a single noise map) of an existing CNN-based model with a lightweight module that outputs multiple noise maps. We propose a novel Noise Decorrelation process to enforce the orthogonality of the noise feature maps, allowing arbitrary noise level control through noise map interpolation. This process is network-free and does not require network inference. Our experiments show that RCD can enable real-time editable image and video denoising for various existing heavy-weight models without sacrificing their original performance., CVPR 2023

The state of the arts in vision-language pretraining (VLP) achieves exemplary performance but suffers from high training costs resulting from slow convergence and long training time, especially on large-scale web datasets. An essential obstacle to training efficiency lies in the entangled prediction rate (percentage of tokens for reconstruction) and corruption rate (percentage of corrupted tokens) in masked language modeling (MLM), that is, a proper corruption rate is achieved at the cost of a large portion of output tokens being excluded from prediction loss. To accelerate the convergence of VLP, we propose a new pretraining task, namely, free language modeling (FLM), that enables a 100% prediction rate with arbitrary corruption rates. FLM successfully frees the prediction rate from the tie-up with the corruption rate while allowing the corruption spans to be customized for each token to be predicted. FLM-trained models are encouraged to learn better and faster given the same GPU time by exploiting bidirectional contexts more flexibly. Extensive experiments show FLM could achieve an impressive 2.5x pretraining time reduction in comparison to the MLM-based methods, while keeping competitive performance on both vision-language understanding and generation tasks. Code will be public at https://github.com/TencentARC/FLM., To appear in CVPR 2023

Recently, the pure camera-based Bird's-Eye-View (BEV) perception removes expensive Lidar sensors, making it a feasible solution for economical autonomous driving. However, most existing BEV solutions either suffer from modest performance or require considerable resources to execute on-vehicle inference. This paper proposes a simple yet effective framework, termed Fast-BEV, which is capable of performing real-time BEV perception on the on-vehicle chips. Towards this goal, we first empirically find that the BEV representation can be sufficiently powerful without expensive view transformation or depth representation. Starting from M2BEV baseline, we further introduce (1) a strong data augmentation strategy for both image and BEV space to avoid over-fitting (2) a multi-frame feature fusion mechanism to leverage the temporal information (3) an optimized deployment-friendly view transformation to speed up the inference. Through experiments, we show Fast-BEV model family achieves considerable accuracy and efficiency on edge. In particular, our M1 model (R18@256x704) can run over 50FPS on the Tesla T4 platform, with 47.0% NDS on the nuScenes validation set. Our largest model (R101@900x1600) establishes a new state-of-the-art 53.5% NDS on the nuScenes validation set. The code is released at: https://github.com/Sense-GVT/Fast-BEV., Accepted by NeurIPS2022_ML4AD on October 22, 2022

Humans possess a versatile mechanism for extracting structured representations of our visual world. When looking at an image, we can decompose the scene into entities and their parts as well as obtain the dependencies between them. To mimic such capability, we propose Visual Dependency Transformers (DependencyViT) that can induce visual dependencies without any labels. We achieve that with a novel neural operator called \emph{reversed attention} that can naturally capture long-range visual dependencies between image patches. Specifically, we formulate it as a dependency graph where a child token in reversed attention is trained to attend to its parent tokens and send information following a normalized probability distribution rather than gathering information in conventional self-attention. With such a design, hierarchies naturally emerge from reversed attention layers, and a dependency tree is progressively induced from leaf nodes to the root node unsupervisedly. DependencyViT offers several appealing benefits. (i) Entities and their parts in an image are represented by different subtrees, enabling part partitioning from dependencies; (ii) Dynamic visual pooling is made possible. The leaf nodes which rarely send messages can be pruned without hindering the model performance, based on which we propose the lightweight DependencyViT-Lite to reduce the computational and memory footprints; (iii) DependencyViT works well on both self- and weakly-supervised pretraining paradigms on ImageNet, and demonstrates its effectiveness on 8 datasets and 5 tasks, such as unsupervised part and saliency segmentation, recognition, and detection., Comment: CVPR 2023

In this work, we present Multi-Level Contrastive Learning for Dense Prediction Task (MCL), an efficient self-supervised method for learning region-level feature representation for dense prediction tasks. Our method is motivated by the three key factors in detection: localization, scale consistency and recognition. To explicitly encode absolute position and scale information, we propose a novel pretext task that assembles multi-scale images in a montage manner to mimic multi-object scenarios. Unlike the existing image-level self-supervised methods, our method constructs a multi-level contrastive loss that considers each sub-region of the montage image as a singleton. Our method enables the neural network to learn regional semantic representations for translation and scale consistency while reducing pre-training epochs to the same as supervised pre-training. Extensive experiments demonstrate that MCL consistently outperforms the recent state-of-the-art methods on various datasets with significant margins. In particular, MCL obtains 42.5 AP$^\mathrm{bb}$ and 38.3 AP$^\mathrm{mk}$ on COCO with the 1x schedule fintuning, when using Mask R-CNN with R50-FPN backbone pre-trained with 100 epochs. In comparison to MoCo, our method surpasses their performance by 4.0 AP$^\mathrm{bb}$ and 3.1 AP$^\mathrm{mk}$. Furthermore, we explore the alignment between pretext task and downstream tasks. We extend our pretext task to supervised pre-training, which achieves a similar performance to self-supervised learning. This result demonstrates the importance of the alignment between pretext task and downstream tasks, indicating the potential for wider applicability of our method beyond self-supervised settings., Comment: Technical report

Large Vision-Language Models (LVLMs) have recently played a dominant role in multimodal vision-language learning. Despite the great success, it lacks a holistic evaluation of their efficacy. This paper presents a comprehensive evaluation of publicly available large multimodal models by building a LVLM evaluation Hub (LVLM-eHub). Our LVLM-eHub consists of $8$ representative LVLMs such as InstructBLIP and MiniGPT-4, which are thoroughly evaluated by a quantitative capability evaluation and an online arena platform. The former evaluates $6$ categories of multimodal capabilities of LVLMs such as visual question answering and embodied artificial intelligence on $47$ standard text-related visual benchmarks, while the latter provides the user-level evaluation of LVLMs in an open-world question-answering scenario. The study reveals several innovative findings. First, instruction-tuned LVLM with massive in-domain data such as InstructBLIP heavily overfits many existing tasks, generalizing poorly in the open-world scenario. Second, instruction-tuned LVLM with moderate instruction-following data may result in object hallucination issues (i.e., generate objects that are inconsistent with target images in the descriptions). It either makes the current evaluation metric such as CIDEr for image captioning ineffective or generates wrong answers. Third, employing a multi-turn reasoning evaluation framework can mitigate the issue of object hallucination, shedding light on developing an effective pipeline for LVLM evaluation. The findings provide a foundational framework for the conception and assessment of innovative strategies aimed at enhancing zero-shot multimodal techniques. Our LVLM-eHub will be available at https://github.com/OpenGVLab/Multi-Modality-Arena, Comment: 28 pages, 10 figures, a comprehensive evaluation of large vision-language models

Additional file 2: Table S1. Definition of persistent and transient HR-HPV infections.

Humans, even at a very early age, can learn visual concepts and understand geometry and layout through active interaction with the environment, and generalize their compositions to complete tasks described by natural languages in novel scenes. To mimic such capability, we propose Embodied Concept Learner (ECL) in an interactive 3D environment. Specifically, a robot agent can ground visual concepts, build semantic maps and plan actions to complete tasks by learning purely from human demonstrations and language instructions, without access to ground-truth semantic and depth supervisions from simulations. ECL consists of: (i) an instruction parser that translates the natural languages into executable programs; (ii) an embodied concept learner that grounds visual concepts based on language descriptions; (iii) a map constructor that estimates depth and constructs semantic maps by leveraging the learned concepts; and (iv) a program executor with deterministic policies to execute each program. ECL has several appealing benefits thanks to its modularized design. Firstly, it enables the robotic agent to learn semantics and depth unsupervisedly acting like babies, e.g., ground concepts through active interaction and perceive depth by disparities when moving forward. Secondly, ECL is fully transparent and step-by-step interpretable in long-term planning. Thirdly, ECL could be beneficial for the embodied instruction following (EIF), outperforming previous works on the ALFRED benchmark when the semantic label is not provided. Also, the learned concept can be reused for other downstream tasks, such as reasoning of object states. Project page: http://ecl.csail.mit.edu/, Comment: CoRL 2022

Instruction tuning large language model (LLM) on image-text pairs has achieved unprecedented vision-language multimodal abilities. However, their vision-language alignments are only built on image-level, the lack of region-level alignment limits their advancements to fine-grained multimodal understanding. In this paper, we propose instruction tuning on region-of-interest. The key design is to reformulate the bounding box as the format of spatial instruction. The interleaved sequences of visual features extracted by the spatial instruction and the language embedding are input to LLM, and trained on the transformed region-text data in instruction tuning format. Our region-level vision-language model, termed as GPT4RoI, brings brand new conversational and interactive experience beyond image-level understanding. (1) Controllability: Users can interact with our model by both language and spatial instructions to flexibly adjust the detail level of the question. (2) Capacities: Our model supports not only single-region spatial instruction but also multi-region. This unlocks more region-level multimodal capacities such as detailed region caption and complex region reasoning. (3) Composition: Any off-the-shelf object detector can be a spatial instruction provider so as to mine informative object attributes from our model, like color, shape, material, action, relation to other objects, etc. The code, data, and demo can be found at https://github.com/jshilong/GPT4RoI., Comment: Code has been released at https://github.com/jshilong/GPT4RoI

Embodied AI is a crucial frontier in robotics, capable of planning and executing action sequences for robots to accomplish long-horizon tasks in physical environments. In this work, we introduce EmbodiedGPT, an end-to-end multi-modal foundation model for embodied AI, empowering embodied agents with multi-modal understanding and execution capabilities. To achieve this, we have made the following efforts: (i) We craft a large-scale embodied planning dataset, termed EgoCOT. The dataset consists of carefully selected videos from the Ego4D dataset, along with corresponding high-quality language instructions. Specifically, we generate a sequence of sub-goals with the "Chain of Thoughts" mode for effective embodied planning. (ii) We introduce an efficient training approach to EmbodiedGPT for high-quality plan generation, by adapting a 7B large language model (LLM) to the EgoCOT dataset via prefix tuning. (iii) We introduce a paradigm for extracting task-related features from LLM-generated planning queries to form a closed loop between high-level planning and low-level control. Extensive experiments show the effectiveness of EmbodiedGPT on embodied tasks, including embodied planning, embodied control, visual captioning, and visual question answering. Notably, EmbodiedGPT significantly enhances the success rate of the embodied control task by extracting more effective features. It has achieved a remarkable 1.6 times increase in success rate on the Franka Kitchen benchmark and a 1.3 times increase on the Meta-World benchmark, compared to the BLIP-2 baseline fine-tuned with the Ego4D dataset.

Contrastive learning methods train visual encoders by comparing views from one instance to others. Typically, the views created from one instance are set as positive, while views from other instances are negative. This binary instance discrimination is studied extensively to improve feature representations in self-supervised learning. In this paper, we rethink the instance discrimination framework and find the binary instance labeling insufficient to measure correlations between different samples. For an intuitive example, given a random image instance, there may exist other images in a mini-batch whose content meanings are the same (i.e., belonging to the same category) or partially related (i.e., belonging to a similar category). How to treat the images that correlate similarly to the current image instance leaves an unexplored problem. We thus propose to support the current image by exploring other correlated instances (i.e., soft neighbors). We first carefully cultivate a candidate neighbor set, which will be further utilized to explore the highly-correlated instances. A cross-attention module is then introduced to predict the correlation score (denoted as positiveness) of other correlated instances with respect to the current one. The positiveness score quantitatively measures the positive support from each correlated instance, and is encoded into the objective for pretext training. To this end, our proposed method benefits in discriminating uncorrelated instances while absorbing correlated instances for SSL. We evaluate our soft neighbor contrastive learning method (SNCLR) on standard visual recognition benchmarks, including image classification, object detection, and instance segmentation. The state-of-the-art recognition performance shows that SNCLR is effective in improving feature representations from both ViT and CNN encoders., Comment: Accepted by ICLR23

Cooperatively utilizing both ego-vehicle and infrastructure sensor data can significantly enhance autonomous driving perception abilities. However, temporal asynchrony and limited wireless communication in traffic environments can lead to fusion misalignment and impact detection performance. This paper proposes Feature Flow Net (FFNet), a novel cooperative detection framework that uses a feature flow prediction module to address these issues in vehicle-infrastructure cooperative 3D object detection. Rather than transmitting feature maps extracted from still-images, FFNet transmits feature flow, which leverages the temporal coherence of sequential infrastructure frames to predict future features and compensate for asynchrony. Additionally, we introduce a self-supervised approach to enable FFNet to generate feature flow with feature prediction ability. Experimental results demonstrate that our proposed method outperforms existing cooperative detection methods while requiring no more than 1/10 transmission cost of raw data on the DAIR-V2X dataset when temporal asynchrony exceeds 200$ms$. The code is available at \href{https://github.com/haibao-yu/FFNet-VIC3D}{https://github.com/haibao-yu/FFNet-VIC3D}., Comment: Under Review

Diffusion models have demonstrated their powerful generative capability in many tasks, with great potential to serve as a paradigm for offline reinforcement learning. However, the quality of the diffusion model is limited by the insufficient diversity of training data, which hinders the performance of planning and the generalizability to new tasks. This paper introduces AdaptDiffuser, an evolutionary planning method with diffusion that can self-evolve to improve the diffusion model hence a better planner, not only for seen tasks but can also adapt to unseen tasks. AdaptDiffuser enables the generation of rich synthetic expert data for goal-conditioned tasks using guidance from reward gradients. It then selects high-quality data via a discriminator to finetune the diffusion model, which improves the generalization ability to unseen tasks. Empirical experiments on two benchmark environments and two carefully designed unseen tasks in KUKA industrial robot arm and Maze2D environments demonstrate the effectiveness of AdaptDiffuser. For example, AdaptDiffuser not only outperforms the previous art Diffuser by 20.8% on Maze2D and 7.5% on MuJoCo locomotion, but also adapts better to new tasks, e.g., KUKA pick-and-place, by 27.9% without requiring additional expert data. More visualization results and demo videos could be found on our project page., Comment: Accepted by ICML 2023. Project page: https://adaptdiffuser.github.io

Placement is a critical step in modern chip design, aiming to determine the positions of circuit modules on the chip canvas. Recent works have shown that reinforcement learning (RL) can improve human performance in chip placement. However, such an RL-based approach suffers from long training time and low transfer ability in unseen chip circuits. To resolve these challenges, we cast the chip placement as an offline RL formulation and present ChiPFormer that enables learning a transferable placement policy from fixed offline data. ChiPFormer has several advantages that prior arts do not have. First, ChiPFormer can exploit offline placement designs to learn transferable policies more efficiently in a multi-task setting. Second, ChiPFormer can promote effective finetuning for unseen chip circuits, reducing the placement runtime from hours to minutes. Third, extensive experiments on 32 chip circuits demonstrate that ChiPFormer achieves significantly better placement quality while reducing the runtime by 10x compared to recent state-of-the-art approaches in both public benchmarks and realistic industrial tasks. The deliverables are released at https://sites.google.com/view/chipformer/home.

Additional file 3: Table S2. Primer sequences and restriction enzymes used for genotyping the studied SNPs.

We present a vision and language model named MultiModal-GPT to conduct multi-round dialogue with humans. MultiModal-GPT can follow various instructions from humans, such as generating a detailed caption, counting the number of interested objects, and answering general questions from users. MultiModal-GPT is parameter-efficiently fine-tuned from OpenFlamingo, with Low-rank Adapter (LoRA) added both in the cross-attention part and the self-attention part of the language model. We first construct instruction templates with vision and language data for multi-modality instruction tuning to make the model understand and follow human instructions. We find the quality of training data is vital for the dialogue performance, where few data containing short answers can lead the model to respond shortly to any instructions. To further enhance the ability to chat with humans of the MultiModal-GPT, we utilize language-only instruction-following data to train the MultiModal-GPT jointly. The joint training of language-only and visual-language instructions with the \emph{same} instruction template effectively improves dialogue performance. Various demos show the ability of continuous dialogue of MultiModal-GPT with humans. Code, dataset, and demo are at https://github.com/open-mmlab/Multimodal-GPT, Comment: 10 pages, 8 figures

Large language models (LLMs) have notably accelerated progress towards artificial general intelligence (AGI), with their impressive zero-shot capacity for user-tailored tasks, endowing them with immense potential across a range of applications. However, in the field of computer vision, despite the availability of numerous powerful vision foundation models (VFMs), they are still restricted to tasks in a pre-defined form, struggling to match the open-ended task capabilities of LLMs. In this work, we present an LLM-based framework for vision-centric tasks, termed VisionLLM. This framework provides a unified perspective for vision and language tasks by treating images as a foreign language and aligning vision-centric tasks with language tasks that can be flexibly defined and managed using language instructions. An LLM-based decoder can then make appropriate predictions based on these instructions for open-ended tasks. Extensive experiments show that the proposed VisionLLM can achieve different levels of task customization through language instructions, from fine-grained object-level to coarse-grained task-level customization, all with good results. It's noteworthy that, with a generalist LLM-based framework, our model can achieve over 60\% mAP on COCO, on par with detection-specific models. We hope this model can set a new baseline for generalist vision and language models. The demo shall be released based on https://github.com/OpenGVLab/InternGPT. The code shall be released at https://github.com/OpenGVLab/VisionLLM., Comment: Technical Report

One-to-one label assignment in object detection has successfully obviated the need for non-maximum suppression (NMS) as postprocessing and makes the pipeline end-to-end. However, it triggers a new dilemma as the widely used sparse queries cannot guarantee a high recall, while dense queries inevitably bring more similar queries and encounter optimization difficulties. As both sparse and dense queries are problematic, then what are the expected queries in end-to-end object detection? This paper shows that the solution should be Dense Distinct Queries (DDQ). Concretely, we first lay dense queries like traditional detectors and then select distinct ones for one-to-one assignments. DDQ blends the advantages of traditional and recent end-to-end detectors and significantly improves the performance of various detectors including FCN, R-CNN, and DETRs. Most impressively, DDQ-DETR achieves 52.1 AP on MS-COCO dataset within 12 epochs using a ResNet-50 backbone, outperforming all existing detectors in the same setting. DDQ also shares the benefit of end-to-end detectors in crowded scenes and achieves 93.8 AP on CrowdHuman. We hope DDQ can inspire researchers to consider the complementarity between traditional methods and end-to-end detectors. The source code can be found at \url{https://github.com/jshilong/DDQ}., Comment: Accepted to CVPR2023. Code has been released at https://github.com/jshilong/DDQ

Understanding the road genome is essential to realize autonomous driving. This highly intelligent problem contains two aspects - the connection relationship of lanes, and the assignment relationship between lanes and traffic elements, where a comprehensive topology reasoning method is vacant. On one hand, previous map learning techniques struggle in deriving lane connectivity with segmentation or laneline paradigms; or prior lane topology-oriented approaches focus on centerline detection and neglect the interaction modeling. On the other hand, the traffic element to lane assignment problem is limited in the image domain, leaving how to construct the correspondence from two views an unexplored challenge. To address these issues, we present TopoNet, the first end-to-end framework capable of abstracting traffic knowledge beyond conventional perception tasks. To capture the driving scene topology, we introduce three key designs: (1) an embedding module to incorporate semantic knowledge from 2D elements into a unified feature space; (2) a curated scene graph neural network to model relationships and enable feature interaction inside the network; (3) instead of transmitting messages arbitrarily, a scene knowledge graph is devised to differentiate prior knowledge from various types of the road genome. We evaluate TopoNet on the challenging scene understanding benchmark, OpenLane-V2, where our approach outperforms all previous works by a great margin on all perceptual and topological metrics. The code would be released soon.

Additional file 3: Table S2. Primer sequences and restriction enzymes used for genotyping the studied SNPs.

The regulation of various cellular processes heavily relies on the protein complexes within a living cell, necessitating a comprehensive understanding of their three-dimensional structures to elucidate the underlying mechanisms. While neural docking techniques have exhibited promising outcomes in binary protein docking, the application of advanced neural architectures to multimeric protein docking remains uncertain. This study introduces SyNDock, an automated framework that swiftly assembles precise multimeric complexes within seconds, showcasing performance that can potentially surpass or be on par with recent advanced approaches. SyNDock possesses several appealing advantages not present in previous approaches. Firstly, SyNDock formulates multimeric protein docking as a problem of learning global transformations to holistically depict the placement of chain units of a complex, enabling a learning-centric solution. Secondly, SyNDock proposes a trainable two-step SE(3) algorithm, involving initial pairwise transformation and confidence estimation, followed by global transformation synchronization. This enables effective learning for assembling the complex in a globally consistent manner. Lastly, extensive experiments conducted on our proposed benchmark dataset demonstrate that SyNDock outperforms existing docking software in crucial performance metrics, including accuracy and runtime. For instance, it achieves a 4.5% improvement in performance and a remarkable millionfold acceleration in speed.

Learning image classification and image generation using the same set of network parameters is a challenging problem. Recent advanced approaches perform well in one task often exhibit poor performance in the other. This work introduces an energy-based classifier and generator, namely EGC, which can achieve superior performance in both tasks using a single neural network. Unlike a conventional classifier that outputs a label given an image (i.e., a conditional distribution $p(y|\mathbf{x})$), the forward pass in EGC is a classifier that outputs a joint distribution $p(\mathbf{x},y)$, enabling an image generator in its backward pass by marginalizing out the label $y$. This is done by estimating the energy and classification probability given a noisy image in the forward pass, while denoising it using the score function estimated in the backward pass. EGC achieves competitive generation results compared with state-of-the-art approaches on ImageNet-1k, CelebA-HQ and LSUN Church, while achieving superior classification accuracy and robustness against adversarial attacks on CIFAR-10. This work represents the first successful attempt to simultaneously excel in both tasks using a single set of network parameters. We believe that EGC bridges the gap between discriminative and generative learning.

Perception systems in modern autonomous driving vehicles typically take inputs from complementary multi-modal sensors, e.g., LiDAR and cameras. However, in real-world applications, sensor corruptions and failures lead to inferior performances, thus compromising autonomous safety. In this paper, we propose a robust framework, called MetaBEV, to address extreme real-world environments involving overall six sensor corruptions and two extreme sensor-missing situations. In MetaBEV, signals from multiple sensors are first processed by modal-specific encoders. Subsequently, a set of dense BEV queries are initialized, termed meta-BEV. These queries are then processed iteratively by a BEV-Evolving decoder, which selectively aggregates deep features from either LiDAR, cameras, or both modalities. The updated BEV representations are further leveraged for multiple 3D prediction tasks. Additionally, we introduce a new M2oE structure to alleviate the performance drop on distinct tasks in multi-task joint learning. Finally, MetaBEV is evaluated on the nuScenes dataset with 3D object detection and BEV map segmentation tasks. Experiments show MetaBEV outperforms prior arts by a large margin on both full and corrupted modalities. For instance, when the LiDAR signal is missing, MetaBEV improves 35.5% detection NDS and 17.7% segmentation mIoU upon the vanilla BEVFusion model; and when the camera signal is absent, MetaBEV still achieves 69.2% NDS and 53.7% mIoU, which is even higher than previous works that perform on full-modalities. Moreover, MetaBEV performs fairly against previous methods in both canonical perception and multi-task learning settings, refreshing state-of-the-art nuScenes BEV map segmentation with 70.4% mIoU., Comment: Project page: https://chongjiange.github.io/metabev.html

Embodied control requires agents to leverage multi-modal pre-training to quickly learn how to act in new environments, where video demonstrations contain visual and motion details needed for low-level perception and control, and language instructions support generalization with abstract, symbolic structures. While recent approaches apply contrastive learning to force alignment between the two modalities, we hypothesize better modeling their complementary differences can lead to more holistic representations for downstream adaption. To this end, we propose Emergent Communication for Embodied Control (EC^2), a novel scheme to pre-train video-language representations for few-shot embodied control. The key idea is to learn an unsupervised "language" of videos via emergent communication, which bridges the semantics of video details and structures of natural language. We learn embodied representations of video trajectories, emergent language, and natural language using a language model, which is then used to finetune a lightweight policy network for downstream control. Through extensive experiments in Metaworld and Franka Kitchen embodied benchmarks, EC^2 is shown to consistently outperform previous contrastive learning methods for both videos and texts as task inputs. Further ablations confirm the importance of the emergent language, which is beneficial for both video and language learning, and significantly superior to using pre-trained video captions. We also present a quantitative and qualitative analysis of the emergent language and discuss future directions toward better understanding and leveraging emergent communication in embodied tasks., Comment: Published in CVPR2023

Joint video-language learning has received increasing attention in recent years. However, existing works mainly focus on single or multiple trimmed video clips (events), which makes human-annotated event boundaries necessary during inference. To break away from the ties, we propose a grounded vision-language learning framework for untrimmed videos, which automatically detects informative events and effectively excavates the alignments between multi-sentence descriptions and corresponding event segments. Instead of coarse-level video-language alignments, we present two dual pretext tasks to encourage fine-grained segment-level alignments, i.e., text-to-event grounding (TEG) and event-to-text generation (ETG). TEG learns to adaptively ground the possible event proposals given a set of sentences by estimating the cross-modal distance in a joint semantic space. Meanwhile, ETG aims to reconstruct (generate) the matched texts given event proposals, encouraging the event representation to retain meaningful semantic information. To encourage accurate label assignment between the event set and the text set, we propose a novel semantic-aware cost to mitigate the sub-optimal matching results caused by ambiguous boundary annotations. Our framework is easily extensible to tasks covering visually-grounded language understanding and generation. We achieve state-of-the-art dense video captioning performance on ActivityNet Captions, YouCook2 and YouMakeup, and competitive performance on several other language generation and understanding tasks. Our method also achieved 1st place in both the MTVG and MDVC tasks of the PIC 4th Challenge. Our code is publicly available at https://github.com/zjr2000/GVL.

Token compression aims to speed up large-scale vision transformers (e.g. ViTs) by pruning (dropping) or merging tokens. It is an important but challenging task. Although recent advanced approaches achieved great success, they need to carefully handcraft a compression rate (i.e. number of tokens to remove), which is tedious and leads to sub-optimal performance. To tackle this problem, we propose Differentiable Compression Rate (DiffRate), a novel token compression method that has several appealing properties prior arts do not have. First, DiffRate enables propagating the loss function's gradient onto the compression ratio, which is considered as a non-differentiable hyperparameter in previous work. In this case, different layers can automatically learn different compression rates layer-wisely without extra overhead. Second, token pruning and merging can be naturally performed simultaneously in DiffRate, while they were isolated in previous works. Third, extensive experiments demonstrate that DiffRate achieves state-of-the-art performance. For example, by applying the learned layer-wise compression rates to an off-the-shelf ViT-H (MAE) model, we achieve a 40% FLOPs reduction and a 1.5x throughput improvement, with a minor accuracy drop of 0.16% on ImageNet without fine-tuning, even outperforming previous methods with fine-tuning. Codes and models are available at https://github.com/OpenGVLab/DiffRate., Comment: 16 pages, 8 figures, 13 tables

This paper studies how to keep a vision backbone effective while removing token mixers in its basic building blocks. Token mixers, as self-attention for vision transformers (ViTs), are intended to perform information communication between different spatial tokens but suffer from considerable computational cost and latency. However, directly removing them will lead to an incomplete model structure prior, and thus brings a significant accuracy drop. To this end, we first develop an RepIdentityFormer base on the re-parameterizing idea, to study the token mixer free model architecture. And we then explore the improved learning paradigm to break the limitation of simple token mixer free backbone, and summarize the empirical practice into 5 guidelines. Equipped with the proposed optimization strategy, we are able to build an extremely simple vision backbone with encouraging performance, while enjoying the high efficiency during inference. Extensive experiments and ablative analysis also demonstrate that the inductive bias of network architecture, can be incorporated into simple network structure with appropriate optimization strategy. We hope this work can serve as a starting point for the exploration of optimization-driven efficient network design. Project page: https://techmonsterwang.github.io/RIFormer/., Comment: 8 pages, accepted by CVPR2023