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4. Diabetes mellitus is not a predictor of poor TB treatment outcomes

Author

I. Baltas, A. Sturdy, K. Kavallieros, A. McGregor, T. Corrah, L. John, G. Cooke, and A. M. Whittington

Subjects
Pulmonary and Respiratory Medicine, Infectious Diseases
Abstract

OBJECTIVE: To investigate whether diabetes mellitus (DM) influences TB treatment outcomes.METHODS: This was a retrospective observational cohort study of all notified TB cases from a large London TB centre over a 5-year period. WHO criteria were used to define TB treatment outcomes.RESULTS: The prevalence of DM at TB treatment initiation was 15% (126/838). Most patients (83.3%, 105/126) were on hypoglycaemic treatment and well-controlled (median glycated haemoglobin 53.5 mmol/mol). DM patients were older, more likely to be of Asian ethnicity and had a higher pre-treatment weight. Time from presentation to treatment initiation was longer (median 87.5 vs. 63 days; P < 0.001), while they were significantly more comorbid (median Charlson Comorbidity Index 3 vs. 0; P < 0.001). Overall, favourable treatment outcomes were recorded for 89.5% of patients (87.7% vs. 89.8% for DM and non-DM patients respectively, P = 0.52). In multivariable analysis, DM was not associated with unfavourable TB treatment outcomes (OR 0.49, 95% CI 0.23–1.04, P = 0.06). Independent predictors of unfavourable outcome included age, cavitation, chronic neurological disease and malignant neoplasm.CONCLUSIONS: In a well-resourced setting, with predominantly well-controlled DM patients on treatment, DM was not an independent predictor of unfavourable TB treatment outcomes.

Published
2023
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8. Multifunctional Core-Shell NiFe2O4 Shield with TiO2/rGO Nanostructures for Biomedical and Environmental Applications

Author

R. Esther Nimshi, J. Judith Vijaya, B. Al-Najar, L. Hazeem, M. Bououdina, L. John Kennedy, K. Kombaiah, and S. Bellucci

Subjects
Inorganic Chemistry, Article Subject, Organic Chemistry, Biochemistry
Abstract

Multifunctional core@shell nanoparticles have been synthesized in this paper through 3 stages: NiFe2O4 nanoparticles by microwave irradiation using Pedalium murex leaf extract as a fuel, core@shell NiFe2O4@TiO2 nanoparticles by sol-gel, and NiFe2O4@TiO2@rGO by sol-gel using preprepared reduced graphene oxide obtained by modified Hummer’s method. XRD analysis confirmed the presence of both cubic NiFe2O4 spinel and tetragonal TiO2 rutile phases, while Raman spectroscopy analysis displays both D and G bands (ID/IG = 1.04) associated with rGO. Morphological observations by HRTEM reveal a core-shell nanostructure formed by NiFe2O4 core as confirmed by SAED with subsequent thin layers of TiO2 and rGO. Magnetic measurements show a ferromagnetic behavior, where the saturation magnetization drops drastically from 45 emu/g for NiFe2O4 to 15 emu/g after TiO2 and rGO nonmagnetic bilayers coating. The as-fabricated multifunctional core@shell nanostructures demonstrate tunable self-heating characteristics: rise of temperature and specific absorption rate in the range of ΔT = 3–10°C and SAR = 3–58 W/g, respectively. This effectiveness is much close to the threshold temperature of hyperthermia (45°C), and the zones of inhibition show the better effective antibacterial activity of NTG against various Gram-positive and Gram-negative bacterial strains besides simultaneous good efficient, stable, and removable sonophotocatalyst toward the TC degradation.

Published
2022
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11. Reduced Graphene Oxide-Tailored CuFe2O4 Nanoparticles as an Electrode Material for High-Performance Supercapacitors

Author

B. Carmel Jeeva Mary, J. Judith Vijaya, Radhika R. Nair, A. Mustafa, P. Stephen Selvamani, B. Saravanakumar, M. Bououdina, and L. John Kennedy

Subjects
Article Subject, General Materials Science
Abstract

Transition metal oxide-based magnetic nanocomposites attract great attention due to their unique properties and applications in the field of energy storage. Herein, we present a facile microwave procedure for the synthesis of CuFe2O4 (CF) and CuFe2O4 incorporated with reduced graphene oxide CuFe2O4/rGO (CG) as potential electrode materials for hybrid supercapacitor. The structure and morphology of CF and CG nanoparticles are examined. The electrochemical performance is studied in 6 M aqueous KOH electrolyte using cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectroscopy (EIS) techniques. The attractive CG nanocomposite exhibits high specific capacity of 800 C/g at a current density of 2 A/g and better cycling stability when compared to pure CF, due to the formation of nanostructure composed of ferrite nanoparticles homogeneously incorporated onto rGO sheets. Furthermore, the practicability of CG electrode is investigated by the fabrication of CG and activated carbon. The hybrid supercapacitor device shows excellent electrochemical performance with specific energy of 18.3 Wh/kg and a specific power of 455 W/kg. It is noteworthy that the cyclic stability is excellent with a capacity retention of ~98% after 3000 cycles manifesting the superiority of CG electrode. The proposed device demonstrates the potential to fabricate other metal oxides with activated carbon via a facile synthesis method for promoting application in energy storage materials and promoting new opportunities of binary nanocomposite.

Published
2022
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13. DNA methylation analysis using bisulphite-based amplicon sequencing of individuals exposed to maternal tobacco use during pregnancy, and offspring conduct problems in childhood and adolescence

Author

Alexandra J. Noble, John F. Pearson, Alasdair D. Noble, Joseph M. Boden, L. John Horwood, Martin A. Kennedy, and Amy J. Osborne

Subjects
Adolescent, DNA Methylation, Tobacco Use, Endocrinology, Reproductive Medicine, Pregnancy, Prenatal Exposure Delayed Effects, Genetics, Humans, Sulfites, Female, Animal Science and Zoology, Molecular Biology, Developmental Biology, Biotechnology
Abstract

Maternal tobacco smoking during pregnancy is a large driver of health inequalities and a higher prevalence of conduct problem (CP) has been observed in exposed offspring. Further, maternal tobacco use during pregnancy can also alter offspring DNA methylation. However, currently, limited molecular evidence has been found to support this observation. Thus we aim to examine the association between maternal tobacco use in pregnancy and offspring CP, to determine whether offspring CP is mediated by tobacco exposure-induced DNA methylation differences. Understanding the etiology of the association between maternal tobacco use and offspring CP will be crucial in the early identification and treatment of CP in children and adolescents. Here, a sub group of N = 96 individuals was sourced from the Christchurch Health and Development Study, a longitudinal birth cohort studied for over 40 years in New Zealand. Whole blood samples underwent bisulphite-based amplicon sequencing at 10 loci known to play a role in neurodevelopment, or which had associations with CP phenotypes. We identified significant (P

Published
2022
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15. Conulariid soft parts replicated in silica from the Scotch Grove Formation (lower Middle Silurian) of east-central Iowa

Author

Heyo Van Iten, Nigel C. Hughes, Douglas L. John, Robert R. Gaines, and Matthew W. Colbert

Subjects
Cnidaria, Medusozoa, Scyphozoa, Conulariida, Silicification, Relic Soft Parts, Paleontology
Abstract

Two specimens of Metaconularia manni (Roy) from the lower Middle Silurian Scotch Grove Formation (eastern Iowa) exhibit well-defined, relict soft parts replicated in silica. One of these specimens bears phosphatic periderm, while the other specimen is a mold. Present within the erect, undistorted apical region of the specimen preserving periderm, on opposite sides of the peridermal cavity, are two small, elongate masses of silica located near the midlines of two of the four faces. Present in the central portion of the other specimen, at a somewhat greater distance from the apex, are five pairs of hollow, elongate, keeled-pouch-like bodies (pouches), the long axes of which converge on the center of the fossil. Each pair of pouches is associated with a short, narrow, gently curved or broadly u-shaped tube, also composed of silica. Additionally, two of the pouch/tube combinations are associated with a pair of rectilinear furrows that correspond to the paired internal carinae that straddled the conulariid’s facial midlines. We interpret the paired pouches and short tubes in the moldic specimen as relic conulariid soft parts homologous, respectively, to the interradial gonads and retractor muscles of extant, stauromedusan and polypoid scyphozoan cnidarians. Unlike most conulariids, which exhibit four faces, this individual had five faces, an aberrant morphology known in one other conulariid. The two small masses in the other specimen are more difficult to interpret, but they, too, may be relic gonads or longitudinal muscles. These interpretations imply that, as in certain extant scyphozoans, at least one conulariid lost the free-living, sexual medusoid life phase. This file is a rendered CT scan of the silicified "rosette" in UWGM 6834 The 3-D geometry of silicified relic soft parts preserved within the specimens and partially obscured by dolomitic rock matrix was determined using ultra-high resolution (Ketcham and Carlson, 2001), 3-D scanning tomography in the University of Texas High-Resolution X-ray CT Facility (Department of Geological Sciences, Jackson School of Geosciences, The University of Texas at Austin). The CT analysis gathered 625 slices, with a slice thickness and interslice spacing of 0.0554 mm and a field of reconstruction of 26 mm, yielding an interpixel spacing of 0.05078 mm. The resultant 3-D model (Fig. 5) was generated using VGStudioMax.

Published
2023
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16. Additional file 1 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 1: Methods 1. Flow chart of the New Zealand 1986 VLBW Cohort follow-up study recruitment process, with inclusion and exclusion criteria for DNA methylation of samples collected at birth and at 28 years.

Published
2023
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17. Additional file 2 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 2: Methods 2. The modified protocol used for extraction of DNA from archived neonatal dried blood spots and the method for bisulphite conversion used prior to analysis on Human MethylationEPIC 850K arrays.

Published
2023
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18. Additional file 15 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 15: Table S6. After PCA was performed on the 18 EBF4 CpGs identified from both adult and neonate methylation data, associations were observed between the first and second principal components (PC1 and PC2) at each age and adult cardiovascular or respiratory traits.

Published
2023
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19. Additional file 11 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 11: Table S5. From the lists of CpGs with differential DNA methylation in VLBW cases versus controls, four overlapped in both neonates and adults and showed several associations with adult cardiovascular and respiratory traits.

Published
2023
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20. Additional file 3 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 3: Table S1. Characteristics of the subset of VLBW cases and controls with neonatal DNA available.

Published
2023
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21. Additional file 10 of DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

Author

Cameron, Vicky A., Jones, Gregory T., Horwood, L. John, Pilbrow, Anna P., Martin, Julia, Frampton, Chris, Ip, Wendy T., Troughton, Richard W., Greer, Charlotte, Yang, Jun, Epton, Michael J., Harris, Sarah L., and Darlow, Brian A.

Abstract

Additional file 10: Tables S4a and S4b. Associations between CpGs with differential DNA methylation in adult samples, DNAm GrimAge and cardiovascular variables (4A) or respiratory traits (4B) at 28 Years.

Published
2023
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24. DNA Methylation Patterns At Birth Predict Health Outcomes In Young Adults Born Very Low Birthweight

Author

Vicky A. Cameron, Gregory T. Jones, L. John Horwood, Anna P. Pilbrow, Julia Martin, Chris Frampton, Wendy T. Ip, Richard W. Troughton, Charlotte Greer, Jun Yang, Michael J. Epton, Sarah L. Harris, and Brian A. Darlow

Subjects
Genetics, Molecular Biology, Genetics (clinical), Developmental Biology
Abstract

Background Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed DNA methylation at birth and at 28 years in the New Zealand (NZ) VLBW cohort (all infants born Results Genomic DNA from archived newborn heel-prick blood (n = 109 VLBW, 51 controls) and from peripheral blood at ~ 28 years (n = 215 VLBW, 96 controls) was analyzed on Illumina Infinium MethylationEPIC 850 K arrays. Following quality assurance and normalization, methylation levels were compared between VLBW cases and controls at both ages by linear regression, with genome-wide significance set to p p = 3.44E−11). The top 20 CpGs that differed most between VLBW cases and controls featured clusters in ARID3A, SPATA33, and PLCH1 and these 3 genes, along with MCF2L, TRBJ2-1 and SRC, led the list of 15,000 differentially methylated regions (DMRs) reaching FDR-adj significance. Fifteen of the 20 top CpGs in the neonate EWAS showed associations between methylation at birth and adult cardiovascular traits (particularly LnRHI). In 28-year-old adults, twelve CpGs differed between VLBW cases and controls at FDR-adjusted significance, including hypermethylation in EBF4 (four CpGs), CFI and UNC119B and hypomethylation at three CpGs in HIF3A and one in KCNQ1. DNA methylation GrimAge scores at 28 years were significantly greater in VLBW cases versus controls and weakly associated with cardiovascular traits. Four CpGs were identified where methylation differed between VLBW cases and controls in both neonates and adults, three reversing directions with age (two CpGs in EBF4, one in SNAI1 were hypomethylated in neonates, hypermethylated in adults). Of these, cg16426670 in EBF4 at birth showed associations with several cardiovascular traits in adults. Conclusions These findings suggest that methylation patterns in VLBW neonates may be informative about future adult cardiovascular and respiratory outcomes and have value in guiding early preventative care to improve adult health.

Published
2022
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25. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Author

Niamh Mullins, JooEun Kang, Adrian I. Campos, Jonathan R.I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark Adams, Swapnil Awasthi, Michael Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi-Chung Chen, Steven Crawford, Scott Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández-Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai-Gwo Hwu, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly L. Klump, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih-Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy M. Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas Craddock, David Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Justine M. Gatt, Pablo V. Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Steven P. Hamilton, Marian L. Hamshere, Annette Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie-Odile Krebs, Mikael Landén, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Müller-Myhsok, Caroline Nievergelt, Vishwajit Nimgaonkar, Markus M. Nöthen, Michael C. O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W.J.H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Dan Rujescu, Cristina Sánchez-Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley I. Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J.S. Sonuga-Barke, Gianfranco Spalletta, John S. Strauss, Beata Świątkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar-Ribó, John B. Vincent, Henry Völzke, James T.R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley-Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Børglum, Gerome Breen, Annette Erlangsen, Tõnu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po-Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Rentería, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia Willour, Douglas M. Ruderfer, Manuel Mattheisen, Abdel Abdellaoui, Mark J. Adams, Till F.M. Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T.F. Beekman, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Jane Hvarregaard Christensen, Toni-Kim Clarke, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Eske M. Derks, Nese Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Yang Wu, Hualin S. Xi, Jian Yang, Futao Zhang, Volker Arolt, Dorret I. Boomsma, Udo Dannlowski, E.J.C. de Geus, J. Raymond Depaulo, Enrico Domenici, Katharina Domschke, Jakob Grove, Lynsey S. Hall, Christine Søholm Hansen, Thomas F. Hansen, Stefan Herms, Ian B. Hickie, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M. Howard, Rick Jansen, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert M. Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Christel M. Middeldorp, Evelin Mihailov, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Hogni Oskarsson, Caroline Hayward, Andrew C. Heath, Glyn Lewis, Pamela A.F. Madden, Patrik K. Magnusson, Andres Metspalu, Sara A. Paciga, Nancy L. Pedersen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Wouter J. Peyrot, Danielle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Saira Saeed Mirza, Robert Schoevers, Eva C. Schulte, Ling Shen, Engilbert Sigurdsson, Grant C.B. Sinnamon, Johannes H. Smit, Hreinn Stefansson, Stacy Steinberg, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Roy H. Perlis, David J. Porteous, Catherine Schaefer, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Patrick F. Sullivan, Kevin S. O’Connell, Brandon Coombes, Zhen Qiao, Thomas D. Als, Sigrid Børte, Alexander W. Charney, Ole Kristian Drange, Michael J. Gandal, Saskia P. Hagenaars, Masashi Ikeda, Nolan Kamitaki, Kristi Krebs, Georgia Panagiotaropoulou, Brian M. Schilder, Laura G. Sloofman, Bendik S. Winsvold, Hong-Hee Won, Liliya Abramova, Kristina Adorjan, Mariam Al Eissa, Diego Albani, Ney Alliey-Rodriguez, Verneri Antilla, Anastasia Antoniou, Ji Hyun Baek, Michael Bauer, Eva C. Beins, Sarah E. Bergen, Armin Birner, Erlend Bøen, Murielle Brum, Ben M. Brumpton, Nathalie Brunkhorst-Kanaan, William Byerley, Murray Cairns, Miquel Casas, Pablo Cervantes, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Julie Cunningham, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Friederike S. David, Amanda L. Dobbyn, Athanassios Douzenis, Torbjørn Elvsåshagen, I. Nicol Ferrier, Alessia Fiorentino, Tatiana M. Foroud, Liz Forty, Oleksandr Frei, Nelson B. Freimer, Louise Frisén, Katrin Gade, Julie Garnham, Ian R. Gizer, Katherine Gordon-Smith, Tiffany A. Greenwood, José Guzman-Parra, Kyooseob Ha, Magnus Haraldsson, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Peter A. Holmans, Laura Huckins, Jessica S. Johnson, Janos L. Kalman, Yoichiro Kamatani, Sarah Kittel-Schneider, Maria Koromina, Thorsten M. Kranz, Michiaki Kubo, Ralph Kupka, Steven A. Kushner, Catharina Lavebratt, Markus Leber, Heon-Jeong Lee, Shawn E. Levy, Catrin Lewis, Martin Lundberg, Sigurdur H. Magnusson, Adam Maihofer, Dolores Malaspina, Eirini Maratou, Lina Martinsson, Nathaniel W. McGregor, James D. McKay, Helena Medeiros, Vincent Millischer, Jennifer L. Moran, Derek W. Morris, Thomas W. Mühleisen, Niamh O’Brien, Claire O’Donovan, Loes M. Olde Loohuis, Lilijana Oruc, Sergi Papiol, Antonio F. Pardiñas, Amy Perry, Andrea Pfennig, Evgenia Porichi, Towfique Raj, Mark H. Rapaport, J. Raymond DePaulo, Eline J. Regeer, Fabio Rivas, Julian Roth, Panos Roussos, Fanny Senner, Sally Sharp, Paul D. Shilling, Claire Slaney, Janet L. Sobell, Maria Soler Artigas, Anne T. Spijker, Dan J. Stein, Chikashi Terao, Claudio Toma, Paul Tooney, Evangelia-Eirini Tsermpini, Marquis P. Vawter, Helmut Vedder, Simon Xi, Wei Xu, Jessica Mei Kay Yang, Allan H. Young, Hannah Young, Peter P. Zandi, Hang Zhou, null HUNT All-In Psychiatry, Gulja Babadjanova, Lena Backlund, Susanne Bengesser, Douglas H.R. Blackwood, Vaughan J. Carr, Stanley Catts, Dimitris Dikeos, Bruno Etain, Panagiotis Ferentinos, Micha Gawlik, Elliot S. Gershon, Frans Henskens, Jan Hillert, Kyung Sue Hong, Christina M. Hultman, Kristian Hveem, Nakao Iwata, Assen V. Jablensky, George Kirov, Christine Lochner, Carmel Loughland, Carol A. Mathews, Francis J. McMahon, Patricia Michie, Bryan Mowry, Benjamin M. Neale, Caroline M. Nievergelt, Ketil J. Oedegaard, Tomas Olsson, Chris Pantelis, George P. Patrinos, Eva Z. Reininghaus, Takeo Saito, Ulrich Schall, Martin Schalling, Rodney J. Scott, Eystein Stordal, Arne E. Vaaler, Eduard Vieta, Irwin D. Waldman, John-Anker Zwart, John I. Nurnberger, Arianna Di Florio, Roger A.H. Adan, Tetsuya Ando, Harald Aschauer, Jessica H. Baker, Vladimir Bencko, Andreas Birgegård, Joseph M. Boden, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Roger D. Cone, Philippe Courtet, James J. Crowley, Unna N. Danner, Oliver S.P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo Martinez, Laramie E. Duncan, Karin Egberts, Morten Mattingsdal, Sara McDevitt, Ingrid Meulenbelt, Nadia Micali, James Mitchell, Karen Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Melissa A. Munn-Chernoff, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O’Toole, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Richard Parker, John F. 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A., Keski-Rahkonen, A., Kiezebrink, K., Kim, Y. -R., Kirk, K. M., Klareskog, L., Knudsen, G. P. S., Larsen, J. T., Le Hellard, S., Leppa, V. M., Lichtenstein, P., Lin, B. D., Lundervold, A., Luykx, J., Maj, M., Mannik, K., Marsal, S., Stuber, G. D., Szatkiewicz, J. P., Tachmazidou, I., Tenconi, E., Tortorella, A., Tozzi, F., Tsitsika, A., Tyszkiewicz-Nwafor, M., Tziouvas, K., van Elburg, A. A., van Furth, E. F., Wade, T. D., Wagner, G., Walton, E., Whiteman, D. C., Wichmann, H. E., Widen, E., Yao, S., Zeggini, E., Zerwas, S., Zipfel, S., Jungkunz, M., Dietl, L., Schwarze, C. E., Dahmen, N., Schott, B. H., Mobascher, A., Crivelli, S., Dennis, M. F., Harvey, P. D., Carter, B. W., Huffman, J. E., Jacobson, D., Madduri, R., Olsen, M. K., Pestian, J., Gaziano, J. M., Muralidhar, S., Ramoni, R., Beckham, J., Chang, K. -M., O'Donnell, C. J., Tsao, P. S., Breeling, J., Huang, G., Romero, J. P. C., Moser, J., Whitbourne, S. B., Brewer, J. V., Aslan, M., Connor, T., Argyres, D. P., Stephens, B., Brophy, M. T., Humphries, D. E., Selva, L. E., Do, N., Shayan, S., Cho, K., Pyarajan, S., Hauser, E., Sun, Y., Zhao, H., Wilson, P., Mcardle, R., Dellitalia, L., Mattocks, K., Harley, J., Zablocki, C. J., Whittle, J., Jacono, F., Gutierrez, S., Gibson, G., Hammer, K., Kaminsky, L., Villareal, G., Kinlay, S., Xu, J., Hamner, M., Mathew, R., Bhushan, S., Iruvanti, P., Godschalk, M., Ballas, Z., Ivins, D., Mastorides, S., Moorman, J., Gappy, S., Klein, J., Ratcliffe, N., Florez, H., Okusaga, O., Murdoch, M., Sriram, P., Yeh, S. S., Tandon, N., Jhala, D., Aguayo, S., Cohen, D., Sharma, S., Liangpunsakul, S., Oursler, K. A., Whooley, M., Ahuja, S., Constans, J., Meyer, P., Greco, J., Rauchman, M., Servatius, R., Gaddy, M., Wallbom, A., Morgan, T., Stapley, T., Sherman, S., Ross, G., Tsao, P., Strollo, P., Boyko, E., Meyer, L., Gupta, S., Huq, M., Fayad, J., Hung, A., Lichy, J., Hurley, R., Robey, B., Striker, R., Erlangsen, A., Kessler, R. C., Porteous, D., Ursano, R. J., Wasserman, D., Coon, H., Demontis, D., Docherty, A. R., Kuo, P. -H., Mann, J. J., Renteria, M. E., Stein, M. B., Willour, V., Psychiatry, Biological Psychology, APH - Methodology, APH - Mental Health, APH - Health Behaviors & Chronic Diseases, AMS - Sports, AMS - Ageing & Vitality, APH - Personalized Medicine, Amsterdam Neuroscience - Complex Trait Genetics, Complex Trait Genetics, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Psychiatry, Department of Public Health, Clinicum, Nuorisopsykiatria, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Anna Keski-Rahkonen / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation, Internal medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Mullins N., Kang J., Campos A.I., Coleman J.R.I., Edwards A.C., Galfalvy H., Levey D.F., Lori A., Shabalin A., Starnawska A., Su M.-H., Watson H.J., Adams M., Awasthi S., Gandal M., Hafferty J.D., Hishimoto A., Kim M., Okazaki S., Otsuka I., Ripke S., Ware E.B., Bergen A.W., Berrettini W.H., Bohus M., Brandt H., Chang X., Chen W.J., Chen H.-C., Crawford S., Crow S., DiBlasi E., Duriez P., Fernandez-Aranda F., Fichter M.M., Gallinger S., Glatt S.J., Gorwood P., Guo Y., Hakonarson H., Halmi K.A., Hwu H.-G., Jain S., Jamain S., Jimenez-Murcia S., Johnson C., Kaplan A.S., Kaye W.H., Keel P.K., Kennedy J.L., Klump K.L., Li D., Liao S.-C., Lieb K., Lilenfeld L., Liu C.-M., Magistretti P.J., Marshall C.R., Mitchell J.E., Monson E.T., Myers R.M., Pinto D., Powers A., Ramoz N., Roepke S., Rozanov V., Scherer S.W., Schmahl C., Sokolowski M., Strober M., Thornton L.M., Treasure J., Tsuang M.T., Witt S.H., Woodside D.B., Yilmaz Z., Zillich L., Adolfsson R., Agartz I., Air T.M., Alda M., Alfredsson L., Andreassen O.A., Anjorin A., Appadurai V., Soler 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Kamitaki N., Krebs K., Panagiotaropoulou G., Schilder B.M., Sloofman L.G., Winsvold B.S., Won H.-H., Abramova L., Adorjan K., Al Eissa M., Albani D., Alliey-Rodriguez N., Antilla V., Antoniou A., Baek J.H., Bauer M., Beins E.C., Bergen S.E., Birner A., Boen E., Brum M., Brumpton B.M., Brunkhorst-Kanaan N., Byerley W., Cairns M., Cervantes P., Cruceanu C., Cuellar-Barboza A., Cunningham J., Curtis D., Czerski P.M., Dale A.M., Dalkner N., David F.S., Dobbyn A.L., Douzenis A., Elvsashagen T., Ferrier I.N., Fiorentino A., Foroud T.M., Forty L., Frei O., Freimer N.B., Frisen L., Gade K., Garnham J., Gelernter J., Gizer I.R., Gordon-Smith K., Greenwood T.A., Ha K., Haraldsson M., Hautzinger M., Heilbronner U., Hellgren D., Holmans P.A., Huckins L., Johnson J.S., Kalman J.L., Kamatani Y., Kittel-Schneider S., Koromina M., Kranz T.M., Kranzler H.R., Kubo M., Kupka R., Kushner S.A., Lavebratt C., Leber M., Lee H.-J., Levy S.E., Lewis C., Lundberg M., Magnusson S.H., Maihofer A., Malaspina D., Maratou E., Martinsson L., McGregor N.W., McKay J.D., Medeiros H., Millischer V., Moran J.L., Morris D.W., Muhleisen T.W., O'Brien N., O'Donovan C., Olde Loohuis L.M., Oruc L., Papiol S., Pardinas A.F., Perry A., Pfennig A., Porichi E., Raj T., Rapaport M.H., Regeer E.J., Rivas F., Roth J., Roussos P., Ruderfer D.M., Senner F., Sharp S., Shilling P.D., Slaney C., Sobell J.L., Artigas M.S., Spijker A.T., Stein D.J., Terao C., Toma C., Tooney P., Tsermpini E.-E., Vawter M.P., Vedder H., Xi S., Xu W., Kay Yang J.M., Young A.H., Young H., Zandi P.P., Zhou H., HUNT All-In Psychiatry, Babadjanova G., Backlund L., Bengesser S., Blackwood D.H.R., Carr V.J., Catts S., Dikeos D., Etain B., Ferentinos P., Gawlik M., Gershon E.S., Henskens F., Hillert J., Hong K.S., Hultman C.M., Hveem K., Iwata N., Jablensky A.V., Kirov G., Lochner C., Loughland C., Mathews C.A., McMahon F.J., Michie P., Mowry B., Neale B.M., Nievergelt C.M., Oedegaard K.J., Olsson T., Pantelis C., Patrinos G.P., Reininghaus E.Z., Saito T., Schall U., Schalling M., Scott R.J., Weickert C.S., Stordal E., Vaaler A.E., Vieta E., Waldman I.D., Zwart J.-A., Nurnberger J.I., Stahl E.A., Di Florio A., Adan R.A.H., Ando T., Aschauer H., Baker J.H., Bencko V., Birgegard A., Boden J.M., Boehm I., Boni C., Perica V.B., Buehren K., Bulik C.M., Burghardt R., Carlberg L., Cassina M., Clementi M., Cone R.D., Courtet P., Crowley J.J., Danner U.N., Davis O.S.P., de Zwaan M., Dedoussis G., Degortes D., DeSocio J.E., Dick D.M., Dina C., Dmitrzak-Weglarz M., Martinez E.D., Duncan L.E., Egberts K., Mattingsdal M., McDevitt S., Meulenbelt I., Micali N., Mitchell J., Mitchell K., Monteleone P., Monteleone A.M., Munn-Chernoff M.A., Nacmias B., Navratilova M., Ntalla I., Olsen C.M., O'Toole J.K., Padyukov L., Palotie A., Pantel J., Papezova H., Parker R., Pearson J.F., Ehrlich S., Escaramis G., Espeseth T., Estivill X., Farmer A., Favaro A., Fischer K., Floyd J.A.B., Focker M., Foretova L., Forzan M., Franklin C.S., Gambaro G., Giuranna J., Giusti-Rodriquez P., Gonidakis F., Gordon S., Mayora M.G., Guillaume S., Hanscombe K.B., Hatzikotoulas K., Hebebrand J., Helder S.G., Henders A.K., Herpertz-Dahlmann B., Herzog W., Hinney A., Horwood L.J., Hubel C., Petersen L.V., Purves K.L., Raevuori A., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rybakowski F., Santonastaso P., Scherag A., Schmidt U., Schork N.J., Schosser A., Seitz J., Slachtova L., Slagboom P.E., Slof-Op 't Landt M.C.T., Slopien A., Soranzo N., Sorbi S., Southam L., Steen V.W., Huckins L.M., Hudson J.I., Imgart H., Inoko H., Janout V., Jordan J., Julia A., Kalsi G., Kaminska D., Kaprio J., Karhunen L., Karwautz A., Kas M.J.H., Kennedy M.A., Keski-Rahkonen A., Kiezebrink K., Kim Y.-R., Kirk K.M., Klareskog L., Knudsen G.P.S., Larsen J.T., Le Hellard S., Leppa V.M., Lichtenstein P., Lin B.D., Lundervold A., Luykx J., Maj M., Mannik K., Marsal S., Stuber G.D., Szatkiewicz J.P., Tachmazidou I., Tenconi E., Tortorella A., Tozzi F., Tsitsika A., Tyszkiewicz-Nwafor M., Tziouvas K., van Elburg A.A., van Furth E.F., Wade T.D., Wagner G., Walton E., Whiteman D.C., Wichmann H.E., Widen E., Yao S., Zeggini E., Zerwas S., Zipfel S., Jungkunz M., Dietl L., Schwarze C.E., Dahmen N., Schott B.H., Mobascher A., Crivelli S., Dennis M.F., Harvey P.D., Carter B.W., Huffman J.E., Jacobson D., Madduri R., Olsen M.K., Pestian J., Gaziano J.M., Muralidhar S., Ramoni R., Beckham J., Chang K.-M., O'Donnell C.J., Tsao P.S., Breeling J., Huang G., Romero J.P.C., Moser J., Whitbourne S.B., Brewer J.V., Aslan M., Connor T., Argyres D.P., Stephens B., Brophy M.T., Humphries D.E., Selva L.E., Do N., Shayan S., Cho K., Pyarajan S., Hauser E., Sun Y., Zhao H., Wilson P., McArdle R., Dellitalia L., Mattocks K., Harley J., Zablocki C.J., Whittle J., Jacono F., Gutierrez S., Gibson G., Hammer K., Kaminsky L., Villareal G., Kinlay S., Xu J., Hamner M., Mathew R., Bhushan S., Iruvanti P., Godschalk M., Ballas Z., Ivins D., Mastorides S., Moorman J., Gappy S., Klein J., Ratcliffe N., Florez H., Okusaga O., Murdoch M., Sriram P., Yeh S.S., Tandon N., Jhala D., Aguayo S., Cohen D., Sharma S., Liangpunsakul S., Oursler K.A., Whooley M., Ahuja S., Constans J., Meyer P., Greco J., Rauchman M., Servatius R., Gaddy M., Wallbom A., Morgan T., Stapley T., Sherman S., Ross G., Tsao P., Strollo P., Boyko E., Meyer L., Gupta S., Huq M., Fayad J., Hung A., Lichy J., Hurley R., Robey B., Striker R., Erlangsen A., Kessler R.C., Porteous D., Ursano R.J., Wasserman D., Coon H., Demontis D., Docherty A.R., Kuo P.-H., Mann J.J., Renteria M.E., Stein M.B., and Willour V.

Subjects
LD SCORE REGRESSION, Genome-wide association study, Suicide, Attempted, 3124 Neurology and psychiatry, 0302 clinical medicine, Risk Factors, Insomnia, Suicide attempt, GWAS, Suïcidi, Depression (differential diagnoses), Cause of death, Psychiatry, 0303 health sciences, Factors de risc en les malalties, Mental Disorders, Genetic Correlation, Genome-wide Association Study, Pleiotropy, Polygenicity, Suicide, Suicide Attempt, DEPRESSION, 3. Good health, Genetic correlation, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Depressive Disorder, Major, Mental illness, Cohort, SEX, medicine.symptom, Human, medicine.medical_specialty, Risk factors in diseases, BF, Locus (genetics), BEHAVIORS, Psykiatri, EVENTS, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, ddc:610, GENOME-WIDE ASSOCIATION, IDEATION, Socioeconomic status, METAANALYSIS, Biological Psychiatry, 030304 developmental biology, business.industry, Risk Factor, Genetic architecture, THOUGHTS, RC0321, business, Malalties mentals, 030217 neurology & neurosurgery
Abstract

Statistical analyses were carried out on the NL Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and the Mount Sinai high performance computing cluster (http://hpc.mssm.edu), which is supported by the Office of Research Infrastructure of the National Institutes of Health (Grant Nos. S10OD018522 and S10OD026880). This work was conducted in part using the resources of the Advanced Computing Center for Research and Education at Vanderbilt University, Nashville, TN. This work was funded by the National Institutes of Health (Grant Nos. R01MH116269 and R01MH121455 [to DMR]), NIGMS of the National Institutes of Health (Grant No. T32GM007347 [to JK]), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Award No. 29551 [to NM])., BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders., Office of Research Infrastructure of the National Institutes of Health S10OD018522 S10OD026880, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA R01MH116269 R01MH121455, NIH National Institute of General Medical Sciences (NIGMS) T32GM007347 NARSAD 29551

Published
2022
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26. A Review of Conventional and Innovative Permanent Support Systems for Rock Cavern Development in Hong Kong

Author

Endicott L John, Franklin K L To, and Andrew K W Seto

Abstract

In recent years, the HKSAR government departments have been playing a leading role to study the feasibility of rock cavern development in Hong Kong. These studies include the relocation of existing surface sewage treatment works, service reservoirs, refuse transfer stations, archive centre and laboratory to rock caverns. After completion of the relocation, the previously occupied surface land can be released for other developments beneficial to the communities. Conventional permanent support systems comprise the cast-in-situ concrete lining with sheet waterproofing membrane. These have been applied in most of the highway and railway tunnels in Hong Kong. However, it involves the use of bulky steel shutter, heavy rebar fixing and an extra set of redundant temporary supports, which leads to very expensive and time-consuming construction. With the advance development in construction technologies, permanent rock reinforcements with sprayed waterproofing membrane could be a cost-effective engineering solution. With the integration of temporary and permanent supports, the tight daily drill-and-blast cycle and timely permanent support installation is greatly enhanced. This paper provides a general review of different conventional and innovative permanent support systems for rock cavern development with the purpose of achieving more efficient design and construction. It also discusses the application according to the unique requirements for various cavern facilities.

Published
2022
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27. Recruitment and retention of participants in longitudinal studies after a natural disaster

Author

Jacki Henderson, Katie M Douglas, Brian A Darlow, Janet K. Spittlehouse, Esther Vierck, Lianne J. Woodward, Joanne Allen, Virginia V.W. McIntosh, Julia Martin, Richard J Porter, Caroline Bell, Jennifer Jordan, Geraldine F. H. McLeod, Joseph M. Boden, Roeline G. Kuijer, Marie Goulden, L. John Horwood, Frances A. Carter, and Julia J. Rucklidge

Subjects
Gerontology, Research Subjects, Natural Disasters, COVID-19, Reproducibility of Results, Cohort Studies, Earthquakes, Humans, Longitudinal Studies, Life-span and Life-course Studies, Natural disaster, Psychology, Pandemics, New Zealand
Abstract

Climate change and population growth will increase vulnerability to natural and human-made disasters or pandemics. Longitudinal research studies may be adversely impacted by a lack of access to study resources, inability to travel around the urban environment, reluctance of sample members to attend appointments, sample members moving residence and potentially also the destruction of research facilities. One of the key advantages of longitudinal research is the ability to assess associations between exposures and outcomes by limiting the influence of sample selection bias. However, ensuring the validity and reliability of findings in longitudinal research requires the recruitment and retention of respondents who are willing and able to be repeatedly assessed over an extended period of time. This study examined recruitment and retention strategies of 11 longitudinal cohort studies operating during the Christchurch, New Zealand earthquake sequence which began in September 2010, including staff perceptions of the major impediments to study operations during/after the earthquakes and respondents’ barriers to participation. Successful strategies to assist recruitment and retention after a natural disaster are discussed. With the current COVID-19 pandemic, longitudinal studies are potentially encountering some of the issues highlighted in this paper including: closure of facilities, restricted movement of research staff and sample members, and reluctance of sample members to attend appointments. It is possible that suggestions in this paper may be implemented so that longitudinal studies can protect the operation of their research programmes.

Published
2022

28. Childhood maltreatment and the menopause transition in a cohort of midlife New Zealand women

Author

Lana, Cleland, Geraldine F H, McLeod, Bhubaneswor, Dhakal, Anna, Fenton, Jacqui-Lyn, Welch, L John, Horwood, and Joseph M, Boden

Subjects
Adult, Cohort Studies, Young Adult, Adolescent, Humans, Female, Child Abuse, Sexual, Menopause, Child, New Zealand, Retrospective Studies
Abstract

Knowledge surrounding the link between childhood adversity and reproductive outcomes at midlife is limited. The present study examined the relationship between childhood maltreatment (childhood sexual abuse [CSA], childhood physical punishment [CPP]), and menopause status at age 40.Data were gathered from female members of the Christchurch Health and Development Study, a longitudinal birth cohort of 1,265 individuals (630 females) born in Christchurch, New Zealand in 1977. Menopause status was defined by categorizing the female cohort at age 40 as either: 1) premenopausal, or 2) peri/ postmenopausal. Retrospective reports of CSA (16 y) and CPP (16 y) were obtained at ages 18 and 21 years.The analysis sample comprised n = 468 women with data recorded on both their menopause status at age 40 and history of maltreatment (16 y), of whom 22% (n = 104) were classified as peri/postmenopausal. A statistically significant association was found between and severity of CSA and menopause status, but not between CPP and menopause status. The association with CSA was robust to control for both childhood confounding factors (16 y) and intervening adult factors (18-40 y) associated with the menopause transition. In the fully adjusted model, women who had experienced severe CSA involving attempted/completed sexual penetration had twice the rate of entering peri/postmenopause compared with those who reported no CSA (39.0% vs 18.8%).Severity of CSA exposure was associated with earlier menopausal transition in this female cohort. These findings are consistent with the emerging literature on the long-term health and developmental impacts of CSA.

Published
2022

30. Evaluation of Vitamin Contents, Antioxidant and Antimicrobial Activities of Different Leaf Extracts of Taraxacum officinale (Dandelion)

Author

P. L. John, I. E. Daniel, and K. N. Mathew

Subjects
Vitamin, chemistry.chemical_compound, Antioxidant, chemistry, Taraxacum officinale, Traditional medicine, medicine.medical_treatment, medicine, General Materials Science, Dandelion, Antimicrobial, Ascorbic acid
Abstract

Methanol and ethyl acetate leaf extracts of Taraxacum officinale (dandelion) were evaluated for phytochemical compounds, vitamins, antioxidant and antimicrobial activities. Phytochemical compounds and vitamins were determined using standard procedures while antioxidant activity was determined using 2, 2’-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing/antioxidant power (FRAP) Assay. Antimicrobial activity against various pathogenic bacteria and fungi were screened using disc diffusion method. The results indicated that the bioactive compounds (total phenol, flavonoids, saponins, tannins and alkaloids) determined quantitatively were present in appreciable concentration in both extracts. The result also showed that both extracts contain a variety of vitamins (A, B complex, C and E), with vitamins C and A having the highest concentration while the B-vitamins (B1, B2 and B3) and vitamin E were present in moderate concentrations. Both extracts showed significant scavenging and reducing ability comparable to the reference antioxidant, ascorbic acid in a dose dependent manner, with methanol exhibiting the highest scavenging and reducing capacity. The antimicrobial activity of both extracts showed appreciable broad spectrum activity against the pathogenic bacteria and fungi strains tested at various concentrations. Methanol extract was found to be most effective compared to ethyl acetate extract. These results indicated that the leaf extracts of dandelion possess antioxidant and antibacterial activity against the tested bacteria possibly due to the presence of bioactive compounds and other nutrients.

Published
2021
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31. Synergic effect of Cu2O/MoS2/rGO for the sonophotocatalytic degradation of tetracycline and ciprofloxacin antibiotics

Author

A. Mustafa, M. Bououdina, P. Stephen Selvamani, R. Jothi Ramalingam, L. John Kennedy, J. Judith Vijaya, and P. Joice Sophia

Subjects
010302 applied physics, Materials science, Nanocomposite, Tetracycline, Process Chemistry and Technology, Composite number, Kinetics, Nanoparticle, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Reaction rate constant, 0103 physical sciences, Materials Chemistry, Ceramics and Composites, medicine, Degradation (geology), 0210 nano-technology, Ternary operation, Nuclear chemistry, medicine.drug
Abstract

A ternary Cu2O/MoS2/rGO (Cu2MG) composite, synthesized by cost-efficient and eco-friendly microwave method, is potentially used for the sonophotocatalytic (visible light and ultrasonic irradiation) degradation of antibiotics namely tetracycline and ciprofloxacin. SEM and TEM observations reveal that the spherical Cu2O nanoparticles are decorated with MoS2 and rGO layered sheets. Furthermore, the incorporation of MoS2/rGO binary composite to Cu2O nanoparticles results in the reduction in fast electron-hole recombination and improve charge carrier ability of Cu2MG composite as confirmed by PL analysis. The Cu2MG composite demonstrates the synergic sonophotocatalytic degradation of Tetracycline (20 mg/L) and Ciprofloxacin (10 mg/L) antibiotics with high efficiency of 100% and 94% within a short duration of 10 min and 75 min, respectively. The kinetics study indicates that the degradation process obeys a pseudo-first order reaction with a rate constant as Ksonophotocatalytic > Kphotocatalytic > Ksonocatalytic. The high synergic value of 3.83 and 1.71 has been achieved for the degradation of TC and CIP antibiotics, respectively. The synergic effect of degradation is owing to the spontaneous production of OH˙ and ˙O2− radicals favoring free electrons to actively participate in the degradation process. This research work proves that the as-fabricated ternary Cu2MG nanocomposite is an efficient candidate for the degradation of antibiotics for better environmental protection.

Published
2021
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32. Effect of preparation techniques on BaWO4: structural, morphological, optical and electron density distribution analysis

Author

L. John Berchmans, Ali Alshehri, R. Sangeetha, D. Sivaganesh, S. Saravanakumar, V. Sivakumar, and K.S. Syed Ali

Subjects
010302 applied physics, Diffraction, Photoluminescence, Materials science, Absorption spectroscopy, Scanning electron microscope, Analytical chemistry, Crystal structure, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Excited state, Scheelite, 0103 physical sciences, Electrical and Electronic Engineering, Spectroscopy
Abstract

The scheelite BaWO4 materials were prepared by co-precipitation and molten salt method. The crystallographic structure, optical behavior, morphology, and electronic charge distributions of the prepared BaWO4 were studied by various spectroscopic techniques such as X-ray power diffraction, photoluminescence spectroscopy, UV–Visible absorption spectroscopy, scanning electron microscopy and electron density distribution analysis, respectively. The micron-sized rock-like structured BaWO4 particles were obtained in the surface morphology. These structured BaWO4 exhibited intense blue emission peak at 430 nm when excited at 375 nm. The synthesized material revealed the high intense blue emission which attributed to the intrinsic transitions of [WO4]2− tetrahedrons.

Published
2021
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33. Magnetically recoverable Mg substituted zinc ferrite nanocatalyst for biodiesel production: Process optimization, kinetic and thermodynamic analysis

Author

Anchu Ashok, T. Ratnaji, L. John Kennedy, R. Gnana Pragash, and J. Judith Vijaya

Subjects
Biodiesel, Materials science, 060102 archaeology, Renewable Energy, Sustainability and the Environment, 020209 energy, 06 humanities and the arts, 02 engineering and technology, Activation energy, Transesterification, Endothermic process, Catalysis, Zinc ferrite, Reaction rate constant, Chemical engineering, Biodiesel production, 0202 electrical engineering, electronic engineering, information engineering, 0601 history and archaeology
Abstract

The purpose of this work is to develop a magnetically recoverable magnesium substituted zinc ferrite nanocatalysts for production of biodiesel from waste cooking oil. Microwave assisted combustion process were employed to synthesis the nanocatalyst. The catalyst were characterized by XRD, FTIR, HR-SEM, EDX, DRS and VSM analysis. The VSM study revealed a relatively high magnetic moment and high saturation magnetization property useful for magnetic separation of the catalyst from the reaction medium. Biodiesel conversion of 99.9% was achieved at the optimized reaction conditions like 3 wt% of Mg2+ doped ZnFe2O4 nanocatalyst (ZnMgF5 sample), reaction temperature about 65ᵒC, methanol-oil molar ratio of 18:1 and reaction time 30 min. Investigation on the transesterification kinetics using ZnMgF5 revealed the rate constants ranging from 0.0375 min−1 to 0.2382 min−1, activation energy Eg = 52 kJ mol−1 and frequency factor A = 2.31 × 107 min−1. The negative values of entropy (ΔS°) indicates, increased randomness of the system. Thermodynamic parameters ΔG° = 87.17 kJ mol−1 at 338 K and ΔH° = 49.31 kJ mol−1 indicate that the transesterification reaction is non-spontaneous and endothermic in nature. The magnetically separated catalyst retained 94% of biodiesel yield even after ten cycles of recovery showing a very good performance.

Published
2021
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34. Dental status of young adults born with very low birthweight: A national cohort study

Author

Victoria A McKelvey, Brian A Darlow, Julia Martin, and L. John Horwood

Subjects
medicine.medical_specialty, Pediatrics, Oral Health, Dental Caries, Oral health, Oral hygiene, National cohort, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Quality of life, Epidemiology, Oral and maxillofacial pathology, Humans, Infant, Very Low Birth Weight, Medicine, 030212 general & internal medicine, Young adult, General Dentistry, business.industry, Confounding, Infant, Newborn, Public Health, Environmental and Occupational Health, 030206 dentistry, medicine.disease, stomatognathic diseases, Quality of Life, business, New Zealand
Abstract

OBJECTIVES Little is known about the oral health of very low birthweight (

Published
2020
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35. The borderline pattern descriptor in the International Classification of Diseases, 11th Revision: A redundant addition to classification

Author

L. John Horwood, Roger T. Mulder, and Peter Tyrer

Subjects
050103 clinical psychology, Computer science, business.industry, media_common.quotation_subject, 05 social sciences, Pattern recognition, General Medicine, Personality Disorders, Spectrum (topology), 030227 psychiatry, Domain (software engineering), Diagnostic and Statistical Manual of Mental Disorders, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Borderline Personality Disorder, International Classification of Diseases, Humans, Personality, 0501 psychology and cognitive sciences, Artificial intelligence, business, media_common
Abstract

Objective: The International Classification of Diseases, 11th Revision classification of personality disorder removes all categories of disorder in favour of a single diagnostic spectrum extending from no personality dysfunction to severe personality disorder. Following concerns from some clinicians and Personality Disorder Societies, it was subsequently agreed to include a borderline pattern descriptor as a qualifier of the main diagnosis. We explore the value of this additional descriptor by examining personality data in patients with major depression. Method: We examined personality data obtained using the Structured Clinical Interview for Personality Disorder-II in 606 patients enrolled in five randomised controlled trials of depression. The Structured Clinical Interview for Personality Disorder-II uses the Diagnostic and Statistical Manual of Mental Disorders categorical system, which includes borderline personality disorder. The International Classification of Diseases, 11th Revision classification has five domain traits. Each of the Diagnostic and Statistical Manual of Mental Disorders personality disorder symptoms or behaviours from Structured Clinical Interview for Personality Disorder-II was reordered into the five domains independently by two assessors. The relationship between the two systems was examined by tabular and correlational analysis. Results: The findings showed that the symptoms of borderline personality disorder were associated with greater severity of personality disturbance in the International Classification of Diseases, 11th Revision classification ( p Conclusion: The addition of a borderline pattern descriptor is likely to add little to the International Classification of Diseases, 11th Revision classification of personality disorder. Its features are well represented within the severity/domain structure, which allows for more fine-grained description of the personality features that constitute the borderline concept.

Published
2020
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37. Magnetically separable Zn1-xCuxFe2O4 (0 ≤ x ≤ 0.5) nanocatalysts for the transesterification of waste cooking oil

Author

L. John Kennedy, Anchu Ashok, J. Judith Vijaya, and T. Ratnaji

Subjects
Materials science, General Chemical Engineering, Spinel, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, Transesterification, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Copper, Nanomaterial-based catalyst, 0104 chemical sciences, Catalysis, Zinc ferrite, chemistry, Mechanics of Materials, Biodiesel production, engineering, Crystallite, 0210 nano-technology
Abstract

Copper doped zinc ferrite Zn1-xCuxFe2O4 (0 ≤ x ≤ 0.5) spinels were synthesized via sonication assisted microwave method. The prepared nanoparticles were characterized by XRD, FTIR, HR-SEM, EDX, DRS and VSM analysis. Average crystallite size were in range 5.84 nm to 8.55 nm. FTIR results reveal, bands at 420 cm−1 (Zn2+ O2−) and 547 cm−1 (Fe3+ O2−) confirming tetrahedral and octahedral positions of the spinel structure formation. All the samples showed ferromagnetic behavior at room temperature. The Zn0.5Cu0.5Fe2O4 sample showed high saturation magnetization (Ms = 74.09 emu/g) and high magnetic moment (3.0 μB). The prepared magnetic nano spinels were subsequently employed to evaluate the catalytic activity for biodiesel production. The transesterification process followed pseudo first order rate kinetic model. An excellent catalytic activity for biodiesel production was acheived (98.9%) and the catalyst was recoverable quickly using an external magnet.

Published
2020
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38. Effect of High-Energy Ball Milling on Molten Salt Synthesized Barium Hexaferrite Powder

Author

Umapathy Mangalanathan, U. Mehana Usmaniya, Shereen Selvaraj, L. John Berchmans, and Uma Gandhi

Subjects
010302 applied physics, Flux method, Materials science, Analytical chemistry, chemistry.chemical_element, Barium, Coercivity, 01 natural sciences, Electronic, Optical and Magnetic Materials, chemistry, Remanence, 0103 physical sciences, Crystallite, Electrical and Electronic Engineering, Fourier transform infrared spectroscopy, Molten salt, Ball mill
Abstract

M-type hexagonal ferrite powder was prepared by the molten salt flux method calcined at a relatively low temperature (850 °C) with a product yield of 99.87%. The synthesized sample was then milled for 3 h by high-energy ball milling in toluene suspension to obtain ultrafine nanoparticles. The structural, morphological, and magnetic properties of the particles were investigated to observe the effect of milling on the molten salt synthesized powder. The analyses reveal the presence of barium hexaferrite (BaFe12O19) as the main phase with less impurities. Average crystallite size, determined by X-ray diffraction (XRD), decreased from 81 ± 20 nm to 52 ± 5 nm after ball milling. The Fourier transform infrared (FTIR) spectra ensure the tetrahedral and octahedral positions in barium hexaferrite structure with an increase in the intensity of absorption bands after milling. The electron paramagnetic resonance (EPR) signal shows a broad line that demonstrates a decrease in the amplitude of the milled sample. Furthermore, remanence measured by vibrating sample magnetometer (VSM) increases from 8.5 to 25 emu/g. A 72% increase in coercivity and 84% increase in magnetic saturation is observed for the milled samples compared to that of pure BaFe12O19 (unmilled). The variations of the magnetic properties are thus attributed to the reduction in crystalline size and lattice parameters after milling.

Published
2020
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39. Network Analysis of Preictal iEEG Reveals Changes in Network Structure Preceding Seizure Onset

Author

Stefan, Sumsky and L John, Greenfield

Subjects
Brain Mapping, Multidisciplinary, Seizures, Brain, Humans, Electroencephalography, Electrocorticography
Abstract

Objective: Seizures likely result from aberrant network activity and synchronization. Changes in brain network connectivity may underlie seizure onset. We used a novel method of rapid network model estimation from intracranial electroencephalography (iEEG) data to characterize pre-ictal changes in network structure prior to seizure onset. Methods: We analyzed iEEG data from 20 patients from the iEEG.org database. Using 10 second epochs sliding by 1 second intervals, a multiple input, single output (MISO) state space model was estimated for each output channel and time point with all other channels as inputs, generating sequential directed network graphs of channel connectivity. These networks were assessed using degree and betweenness centrality.Results: Both degree and betweenness increased at seizure onset zone (SOZ) channels 37.0 ± 2.8 seconds before seizure onset. Degree rose in all channels 8.2 ± 2.2 seconds prior to seizure onset, with increasing connections between the SOZ and surrounding channels. Interictal networks showed low and stable connectivity.Significance: A novel MISO model-based network estimation method identified changes in brain network structure just prior to seizure onset. Increased connectivity was initially isolated within the SOZ and spread to non-SOZ channels before electrographic seizure onset. Such models could help confirm localization of SOZ regions.

Published
2022
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40. Self-reported executive function problems in adults born very low birthweight

Author

Hyun Min Kim, L. John Horwood, Sarah L. Harris, Samudragupta Bora, Brian A. Darlow, and Lianne J. Woodward

Subjects
Adult, Cohort Studies, Parents, Executive Function, Young Adult, Epidemiology, Pediatrics, Perinatology and Child Health, Infant, Newborn, Humans, Infant, Infant, Very Low Birth Weight, Self Report, Child
Abstract

Executive function difficulties are common among children born very preterm and/or very low birthweight (1500 g; VLBW), but little is known about whether they persist into adulthood.Examine the nature and pattern of self-reported executive functioning at 23 and 28 years of age using data from a national cohort study of adults born VLBW and a comparison group of same-age full-term (FT) born adults. Also examined were associations between executive function difficulties and socio-economic outcomes.All infants born VLBW in New Zealand during 1986 were prospectively included in an audit of retinopathy of prematurity (n = 413), with 250 (77% of survivors) followed to median age 28 years. A comparison group of FT adults was also recruited at age 23 and followed to 28 years (n = 100). Across both adult assessments, executive functioning was assessed using the Behaviour Rating Inventory of Executive Function-Adult Version (BRIEF-A) and analysed with semi-parametric models to examine the effects of age and group on executive function.At 23 and 28 years, VLBW adults had increased risk of executive function impairment compared with FT adults in behaviour regulation (relative risk [CI] 2.37, 95% confidence interval (CI)1.27, 4.45), meta-cognition (RR 6.03, 95% CI 2.18, 16.78) and global functioning (RR 3.20, 95% CI 1.40, 7.28). Impaired global executive functioning was associated with lower socio-economic status (regression estimate [b] = -0.43, 95% CI -0.59, -0.27) and a reduced likelihood of home ownership by age 28 years (RR 0.98, 95% CI 0.96, 1.00), even after controlling for sex, ethnicity and parental socio-economic backgrounds for both groups.VLBW-born adults continue to experience more executive function difficulties in their everyday life relative to term controls at age 28 years. These difficulties were negatively associated with their socio-economic opportunities as young adults.

Published
2022

41. Little evidence for long-term harm from antenatal corticosteroids in a population-based very low birthweight young adult cohort

Author

Brian A. Darlow, Sarah L. Harris, and L. John Horwood

Subjects
Young Adult, Epidemiology, Adrenal Cortex Hormones, Pregnancy, Pediatrics, Perinatology and Child Health, Infant, Newborn, Parturition, Humans, Infant, Infant, Very Low Birth Weight, Female, Infant, Premature, Diseases, Follow-Up Studies
Abstract

Antenatal corticosteroids (ACS) given to mothers with anticipated very preterm delivery are widely used and improve infant outcomes. Follow-up studies of the first trials of ACS have shown no adverse effects, but recently there have been concerns about possible longer-term harms.We aimed to assess the relationship of ACS therapy to a range of physical health and welfare measures in a cohort of very low birthweight (VLBW;1500 g) young adults.Population-based cohort follow-up study. All VLBW infants born in New Zealand in 1986 were included in a prospective audit of retinopathy of prematurity. Perinatal data collection included information on ACS. At 26-30 years, 250 of 323 (77%) survivors participated, 58% having received ACS, with 229 assessed in one centre, including cardiovascular, metabolic, respiratory and neurocognitive measures. Differences in outcome between those receiving/not receiving ACS were summarised by the mean difference for continuous outcomes supplemented by Cohen's d as a standardised measure of effect size (ES), and risk ratios (RRI) for dichotomous outcomes, adjusted for relevant covariates using generalised linear regression methods.There were no or minimal adverse effects of receipt of ACS versus no receipt across a range of health and welfare outcomes, both for the full cohort (adjusted ES range d = 0.01-0.23; adjusted RR range 0.78-2.03) and for individuals with gestation28 weeks (extremely preterm; EP), except for a small increase in rates of major depression. In EP adults, receipt of ACS was associated with a higher incidence of hypertension, but might have a small benefit for IQ.In this population-based VLBW cohort, we detected minimal adverse outcomes associated with exposure to ACS by the third decade of life, a similar result to the 30-year follow-up of participants in the first ACS trial. However, further follow-up is warranted.

Published
2022

42. Factors associated with the use of salvage whole brain radiation therapy versus salvage stereotactic radiosurgery after initial stereotactic radiosurgery for brain metastases

Author

Yash S, Soni, Benjamin J, Rich, Deukwoo, Kwon, Wei, Zhao, Danny L, John, Crystal, Seldon, Jessica, Meshman, Ronald, Benveniste, Ricardo J, Komotar, Macarena, de la Fuente, Maria Del Pilar, Guillermo Prieto, Gregory, Azzam, Eric A, Mellon, Carolina G, Benjamin, and Tejan, Diwanji

Subjects
Clinical Investigation
Abstract

OBJECTIVES: Patients undergoing stereotactic radiosurgery (SRS) for brain metastases require additional radiation for relapse. Our objective is to determine the factors associated with salvage SRS versus whole brain radiation therapy (WBRT) for salvage of first intracranial failure (ICF) after upfront SRS. METHOD: We identified a cohort of 110 patients with brain metastases treated with SRS in the definitive or postoperative setting followed by subsequent salvage WBRT or SRS at least one month after initial SRS. Clinical and demographic characteristics were retrospectively recorded. RESULTS: 78 Patients received SRS and 32 patients received WBRT at the time of first ICF. On multivariate analysis (MVA) factors associated with decreased use of salvage SRS were male gender (p=0.044) and local progression (p

Published
2022

43. Diagnostic accuracy of the Abbott ID NOW SARS-CoV-2 rapid test for the triage of acute medical admissions

Author

J.R. Barnacle, H. Houston, I. Baltas, J. Takata, K. Kavallieros, N. Vaughan, A.K. Amin, S.A. Aali, K. Moore, P. Milner, A. Gupta Wright, and L. John

Subjects
Microbiology (medical), Adult, Infectious Diseases, COVID-19 Testing, SARS-CoV-2, COVID-19, Humans, RNA, General Medicine, Triage, Sensitivity and Specificity
Abstract

Decisions to isolate patients at risk of having coronavirus disease 2019 (COVID-19) in the emergency department (ED) must be rapid and accurate to ensure prompt treatment and maintain patient flow whilst minimising nosocomial spread. Reverse transcription polymerase chain reaction (RT-PCR) assays are too slow to achieve this, and near-patient testing is being used increasingly to facilitate triage. The ID NOW severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) assay is an isothermal nucleic acid amplification near-patient test which targets the RNA-dependent RNA-polymerase gene.To assess the diagnostic performance of ID NOW as a COVID-19 triage tool for medical admissions from the ED of a large acute hospital.All adult acute medical admissions from the ED between 31Two percent (124/6050) of medical admissions were SARS-CoV-2 positive on RT-PCR. Compared with PCR, ID NOW had sensitivity and specificity of 83.1% [95% confidence interval (CI) 75.4-88.7] and 99.5% (95% CI 99.3-99.6), respectively. PPV and NPV were 76.9% (95% CI 69.0-83.2) and 99.6% (95% CI 99.5-99.8), respectively. The median time from arrival in the ED to ID NOW result was 59 min.ID NOW provides a rapid and reliable adjunct for the safe triage of patients with COVID-19, and can work effectively when integrated into an ED triage algorithm.

Published
2022

46. sj-docx-1-anp-10.1177_00048674221138499 – Supplemental material for The long-term impacts of the Canterbury earthquakes on the mental health of the Christchurch Health and Development Study cohort

Author

Beaglehole, Ben, Boden, Joseph M, Bell, Caroline, Mulder, Roger T, Dhakal, Bhubaneswor, and Horwood, L John

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674221138499 for The long-term impacts of the Canterbury earthquakes on the mental health of the Christchurch Health and Development Study cohort by Ben Beaglehole, Joseph M Boden, Caroline Bell, Roger T Mulder, Bhubaneswor Dhakal and L John Horwood in Australian & New Zealand Journal of Psychiatry

Published
2022
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48. Molecular detection of quaternary ammonium compound resistance genes of Staphylococcus aureus from udder surface and mastitis milk of bovines

Author

S. Vignesh, R. L. Rathish, K. C. Bipin, L. John, and P. M. Deepa

Abstract

Quaternary ammonium compounds (QAC) are widely used biocides in the field of medical and veterinary practice. Resistance to QACs is an emerging problem due to this widespread use. The present study was undertaken to detect the presence of genes that contribute to resistance to QACs in Staphylococcus aureus isolates obtained from udder surface and mastitis milk. A total 22 isolates of S. aureus were obtained from udder washings and milk of bovine mastitis cases. Among these, seventeen isolates were from udder wash samples and five isolates from clinical and subclinical cases of mastitis. Broth microdilution assay was performed to assess the minimum inhibitory concentration (MIC) of the isolates against Cetyltrimethylammonium bromide (CTAB), a QAC. Polymerase chain reaction (PCR) was done targeting qac A/B gene which codes for efflux pump which targets QACs. In the present study qac A/B gene was detected in seven out of 22 isolates of S. aureus. Three of these isolates were obtained from udder washings before milking and four, after milking. None of the S. aureus isolates from mastitis milk possessed the gene. The average minimum inhibitory concentration of qac A/B positive isolates against CTAB was 0.63 ± 0.55 μg/ml. The average MIC between qac A/B positive and negative isolates were statistically insignificant. The study points to the fact that multiple factors could be contributing to biocide resistance in S. aureus.

Published
2022
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49. List of contributors

Author

M. Basheer Ahamed, Mustafa Farag Ibrahim Aly Rakha, Jamilur R. Ansari, Amir Hossein Behroozi, Ashok Chhetry, Ying-Hui Chin, Chunxiang Dall’Agnese, Yohan Dall’Agnese, Desagani Dayananda, Kalim Deshmukh, George Elsa, Zahra Fakhraai, Alireza Hemmati, Chaudhery Mustansar Hussain, Zeeshan Haider Jaffari, Xin Jin, M. Johnson, Poliraju Kalluru, Tathagata Kar, Mani Karthik, Rüstem Keçili, L. John Kennedy, Mohan Kumar Kesarla, Gyan Raj Koirala, Tomáš Kovářík, Y. Ravi Kumar, Naresh Kuthala, Sze-Mun Lam, Haixiang Li, Xingyou Liang, Hua Lin, Anmin Liu, Tingli Ma, Abdul Rahman Mohamed, M. Mohamed Naseer Ali, Aqib Muzaffar, Kallayi Nabeela, Aamani Nirogi, Dhananjaya Panda, Mayank Pandey, Deependra Parajuli, S.K. Khadheer Pasha, Deepalekshmi Ponnamma, Jothi Ramalingam Rajabathar, Kalagadda Venkateswara Rao, M. Sai Bhargava Reddy, P. Lokanatha Reddy, Kishor Kumar Sadasivuni, Pachagounder Sakthivel, K. Samatha, Ammaiyappan Bharathi Sankar, Kailasa Saraswathi, A.M. Schornack, Ahmad Arabi Shamsabadi, Jin-Chung Sin, Masoud Soroush, N.B. Sumina, Yuliang Sun, Zhimei Sun, Choudhary Arjun Sunilbhai, Suresh Thangudu, Jayaraman Theerthagiri, Raviraj Vankayala, Nachimuthu Venkatesh, Manavalan Vijayakumar, D. Wang, Xiao-Feng Wang, Sadiya Waseem, Lin Yang, Zi-Jun Yong, Yadong Yu, Honghu Zeng, Chao Zhang, Q. Zhang, and Jian Zhou

Published
2022
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50. ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study

Author

Rachel Robinson, Polina Girchenko, Anna Pulakka, Kati Heinonen, Anna Lähdepuro, Marius Lahti-Pulkkinen, Petteri Hovi, Marjaana Tikanmäki, Peter Bartmann, Aulikki Lano, Lex W. Doyle, Peter J. Anderson, Jeanie L. Y. Cheong, Brian A. Darlow, Lianne J. Woodward, L. John Horwood, Marit S. Indredavik, Kari Anne I. Evensen, Neil Marlow, Samantha Johnson, Marina Goulart de Mendonca, Eero Kajantie, Dieter Wolke, Katri Räikkönen, Tampere University, and Welfare Sciences

Subjects
Lav fødselsvekt, Preterm fødsel, 515 Psychology, RJ, Midical sciences: 700 [VDP], Pediatrics, Perinatology and Child Health, BF, ADHD, Preterm birth, Low birth weigth, Medisinske fag: 700 [VDP], RC
Abstract

Background This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns. Methods (1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978–1995) examined differences in self-reported ADHD symptoms[age 18–36 years]; and (3) a population-based register-linkage study of all live births in Finland (01/01/1987–31/12/1998; n = 37538 preterm, n = 691,616 term) examined ADHD diagnosis risk in adulthood (≥18 years) until 31/12/2016. Results Systematic review results were conflicting. In the IPD meta-analysis, ADHD symptoms levels were similar across groups (mean z-score difference 0.00;95% confidence interval [95% CI] −0.07, 0.07). Whereas in the register-linkage study, adults born preterm had a higher relative risk (RR) for ADHD diagnosis compared to term controls (RR = 1.26, 95% CI 1.12, 1.41, p p z-score (RR = 0.88, 95% CI 0.80, 0.97, p Conclusions While preterm adults may not report higher levels of ADHD symptoms, their risk of ADHD diagnosis in adulthood is higher. Impact Preterm-born adults do not self-report higher levels of ADHD symptoms, yet are more likely to receive an ADHD diagnosis in adulthood compared to term-borns. Previous evidence has consisted of limited sample sizes of adults and used different methods with inconsistent findings. This study assessed adult self-reported symptoms across 8 harmonized cohorts and contrasted the findings with diagnosed ADHD in a population-based register-linkage study. Preterm-born adults may not self-report increased ADHD symptoms. However, they have a higher risk of ADHD diagnosis, warranting preventive strategies and interventions to reduce the presentation of more severe ADHD symptomatology in adulthood.

Published
2022

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