388 results on '"Kyung Mo Kim"'
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2. Management and monitoring of pediatric inflammatory bowel disease in the Asia‐Pacific region: A position paper by the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group: Surgical management, disease monitoring, and special considerations
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Way Seah, Lee, Katsuhiro, Arai, George, Alex, Suporn, Treepongkaruna, Kyung Mo, Kim, Chee Liang, Choong, Karen Calixto, Mercado, Andy, Darma, Anshu, Srivastava, and Marion M, Aw
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Hepatology ,Gastroenterology - Abstract
Disease phenotype of pediatric inflammatory bowel disease (PIBD) in children from the Asia Pacific region differs from that of children from the West. Many parts of Asia are endemic for tuberculosis, making diagnosis and management of pediatric Crohn's disease a challenge. Current available guidelines, mainly from Europe and North America, may not be completely applicable to clinicians caring for children with PIBD in Asia due to differences in disease characteristics and regional resource constraints. This position paper is an initiative from the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition (APPSPGHAN) that aims to provide an up-to-date, evidence-based approach to PIBD in the Asia Pacific region. A group of pediatric gastroenterologists with a special interest in PIBD performed an extensive literature search covering epidemiology, disease characteristics and natural history, management and monitoring. Attention was paid to publications from the region with special consideration to a resource-limited setting. This current Position Paper deals with surgical management, disease monitoring, immunization, bone health and nutritional issues of PIBD in Asia. A special section on differentiating pediatric Crohn's disease from tuberculosis in children is included. Conclusion: This position paper provides a useful guide to clinicians in the surgical management, disease monitoring and various health issues in children with IBD in Asia Pacific region.
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- 2023
3. Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study
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Shannon M, Vandriel, Li-Ting, Li, Huiyu, She, Jian-She, Wang, Melissa A, Gilbert, Irena, Jankowska, Piotr, Czubkowski, Dorota, Gliwicz-Miedzińska, Emmanuel M, Gonzales, Emmanuel, Jacquemin, Jérôme, Bouligand, Nancy B, Spinner, Kathleen M, Loomes, David A, Piccoli, Lorenzo, D'Antiga, Emanuele, Nicastro, Étienne, Sokal, Tanguy, Demaret, Noelle H, Ebel, Jeffrey A, Feinstein, Rima, Fawaz, Silvia, Nastasio, Florence, Lacaille, Dominique, Debray, Henrik, Arnell, Björn, Fischler, Susan, Siew, Michael, Stormon, Saul J, Karpen, Rene, Romero, Kyung Mo, Kim, Woo Yim, Baek, Winita, Hardikar, Sahana, Shankar, Amin J, Roberts, Helen M, Evans, M Kyle, Jensen, Marianne, Kavan, Shikha S, Sundaram, Alexander, Chaidez, Palaniswamy, Karthikeyan, Maria Camila, Sanchez, Maria Lorena, Cavalieri, Henkjan J, Verkade, Way Seah, Lee, James E, Squires, Christina, Hajinicolaou, Chatmanee, Lertudomphonwanit, Ryan T, Fischer, Catherine, Larson-Nath, Yael, Mozer-Glassberg, Cigdem, Arikan, Henry C, Lin, Jesus Quintero, Bernabeu, Seema, Alam, Deirdre A, Kelly, Elisa, Carvalho, Cristina Targa, Ferreira, Giuseppe, Indolfi, Ruben E, Quiros-Tejeira, Pinar, Bulut, Pier Luigi, Calvo, Zerrin, Önal, Pamela L, Valentino, Dev M, Desai, John, Eshun, Maria, Rogalidou, Antal, Dezsőfi, Sabina, Wiecek, Gabriella, Nebbia, Raquel Borges, Pinto, Victorien M, Wolters, María Legarda, Tamara, Andréanne N, Zizzo, Jennifer, Garcia, Kathleen, Schwarz, Marisa, Beretta, Thomas Damgaard, Sandahl, Carolina, Jimenez-Rivera, Nanda, Kerkar, Jernej, Brecelj, Quais, Mujawar, Nathalie, Rock, Cristina Molera, Busoms, Wikrom, Karnsakul, Eberhard, Lurz, Ermelinda, Santos-Silva, Niviann, Blondet, Luis, Bujanda, Uzma, Shah, Richard J, Thompson, Bettina E, Hansen, Binita M, Kamath, Arıkan, Çiğdem (ORCID 0000-0002-0794-2741 & YÖK ID 240198), Vandriel, S.M., Li, L.T., She, H., Wang, J.S., Gilbert, M.A., Jankowska, I., Czubkowski, P., Gliwicz-Miedzi?ska, D., Gonzales, E.M., Jacquemin, E., Bouligand, J., Spinner, N.B., Loomes, K.M., Piccoli, D.A., D'Antiga, L., Nicastro, E., Sokal, É., Demaret, T., Ebel, N.H., Feinstein, J.A., Fawaz, R., Nastasio, S., Lacaille, F., Debray, D., Arnell, H., Fischler, B., Siew, S., Stormon, M., Karpen, S.J., Romero, R., Kim, K.M., Baek, W.Y., Hardikar, W., Shankar, S., Roberts, A.J., Evans, H.M., Jensen, M.K., Kavan, M., Sundaram, S.S., Chaidez, A., Karthikeyan, P., Sanchez, M.C., Cavalieri, M.L., Verkade, H.J., Lee, W.S., Squires, J.E., Hajinicolaou, C., Lertudomphonwanit, C., Fischer, R.T., Larson-Nath, C., Mozer-Glassberg, Y., Lin, H.C., Quintero, Bernabeu J., Alam, S., Kelly, D., Carvalho, E., Ferreira, C.T., Indolfi, G., Quiros-Tejeira, R.E., Bulut, P., Calvo, P.L., Önal, Z., Valentino, P.L., Desai, D.M., Eshun, J., Rogalidou, M., Dezs?fi, A., Wiecek, S., Nebbia, G., Borges Pinto, R., Wolters, V.M., Tamara, M.L., Zizzo, A.N., Garcia, J., Schwarz, K., Beretta, M., Sandahl, T.D., Jimenez-Rivera, C., Kerkar, N., Brecelj, J., Mujawar, Q., Rock, N., Busoms, C.M., Karnsakul, W., Lurz, E., Santos-Silva, E., Blondet, N., Bujanda, L., Shah, U., Thompson, R.J., Hansen, B.E., Kamath, B.M., Global ALagille Alliance (GALA) Study Group, Koç University Hospital, School of Medicine, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
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Male ,Cholestasis ,Alagille syndrome ,Bile duct atresia ,Intrahepatic cholestasis ,Hepatology ,Hypertension, Portal/etiology ,Gastroenterology and hepatology ,Alagille Syndrome/epidemiology ,Humans ,Female ,Child ,Retrospective Studies - Abstract
Background and aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real-world data are lacking. This study aimed to elucidate the natural history of liver disease in a contemporary, international cohort of children with ALGS. Approach and results: This was a multicenter retrospective study of children with a clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 and August 2019. Native liver survival (NLS) and event-free survival rates were assessed. Cox models were constructed to identify early biochemical predictors of clinically evident portal hypertension (CEPH) and NLS. In total, 1433 children (57% male) from 67 centers in 29 countries were included. The 10 and 18-year NLS rates were 54.4% and 40.3%. By 10 and 18 years, 51.5% and 66.0% of children with ALGS experienced >= 1 adverse liver-related event (CEPH, transplant, or death). Children (>6 and = 5.0 and = 10.0 mg/dl had an 8.0-fold (95% CI, 3.4-18.4) increased risk of developing CEPH compared with those 10.0 mg/dl were associated with a 4.8 (95% CI, 2.4-9.7) and 15.6 (95% CI, 8.7-28.2) increased risk of transplantation relative to = 5.0 mg/dl, with 79% reaching adulthood with native liver (p < 0.001). Conclusions: in this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. A TB, This study received funding support from the following agencies: The Alagille Syndrome Alliance, Mirum Pharmaceuticals Inc. and Albireo Pharma, Inc. who provided unrestricted educational grants to the Hospital for Sick Children (SickKids Foundation). The study sponsors were not involved in the conduct of the research study or preparation of the manuscript.
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- 2022
4. Analysis of the Effects of Different Nanofluids on Critical Heat Flux Using Artificial Intelligence
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Duarte, Bruno Pinheiro Serrao, Kyung Mo Kim, and Juliana Pacheco
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nanoparticles ,nanofluids ,pool boiling ,critical heat flux ,machine learning - Abstract
Nanofluid (NF) pool boiling experiments have been conducted widely in the past two decades to study and understand how nanoparticles (NP) affect boiling heat transfer and critical heat flux (CHF). However, the physical mechanisms related to the improvements in CHF in NF pool boiling are still not conclusive due to the coupling effects of the surface characteristics and the complexity of the experimental data. In addition, the current models for pool boiling CHF prediction, which consider surface microstructure characteristics, show limited agreement with the experimental data and do not represent NF pool boiling CHF. In this scenario, artificial intelligence tools, such as machine learning (ML) regressor models, are a very promising means of solving this nonlinear problem. This study focuses on creating a new model to provide more accurate NF pool boiling CHF predictions based on pressure, substrate thermal effusivity, and NP size, concentration, and effusivity. Three ML models (supporting vector regressor—SVR, multi-layer perceptron—MLP, and random forest—RF) were constructed and showed good agreement with an experimental database built from the literature, with MLP presenting the highest mean R2 score and the lowest variability. A systematic methodology for optimizing the ML models is proposed in this work.
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- 2023
- Full Text
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5. Analysis of Pipe Thickness Thinning by Flow Accelerated Corrosion Using Ultrasonic Testing
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Se-Beom Oh, Jong-Yeon Lee, Dong-Jin Kim, Kyung-Mo Kim, and Jongbeom Kim
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- 2022
6. Endovascular stenting for late-onset stricture of interposed portal vein conduit following pediatric liver transplantation
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Jung-Man Namgoong, Shin Hwang, Gi-Young Ko, Gil-Chun Park, Kyung Mo Kim, and Seak Hee Oh
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General Materials Science - Published
- 2023
7. Living donor liver transplantation with graft dextro-rotation and vein interposition in a pediatric patient with congenital absence of the portal vein
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Jung-Man Namgoong, Shin Hwang, Gil-Chun Park, Sang-Hoon Kim, Kyung Mo Kim, and Seak Hee Oh
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General Materials Science - Published
- 2023
8. Development and validation of a machine learning–based prediction model for detection of biliary atresia
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Ho Jung Choi, Yeong Eun Kim, Jung-Man Namgoong, Inki Kim, Jun Sung Park, Woo Im Baek, Byong Sop Lee, Hee Mang Yoon, Young Ah Cho, Jin Seong Lee, Jung Ok Shim, Seak Hee Oh, Jin Soo Moon, Jae Sung Ko, Dae Yeon Kim, and Kyung Mo Kim
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- 2023
9. Living donor liver transplantation with hyperreduced segment II monosegment graft for an infant weighing 3 kilograms
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Jung-Man Namgoong, Gil-Chun Park, Shin Hwang, Sang-Hoon Kim, Suhyeon Ha, Kyung Mo Kim, and Seak Hee Oh
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General Materials Science - Published
- 2023
10. Modified left liver graft with funneling venoplasty of middle hepatic vein branches for pediatric living donor liver transplantation
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Jung-Man Namgoong, Gil-Chun Park, Shin Hwang, Sang-Hoon Kim, Suhyeon Ha, Kyung Mo Kim, and Seak Hee Oh
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General Materials Science - Published
- 2023
11. Data from The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
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Chang-Woo Lee, Heounjeong Go, Su-Jin Shin, Ho Lee, Dongryeol Ryu, Baeki E. Kang, Joon-Sup Yoon, Eun-Ji Park, Jiwon Ko, Jin-Kwan Lee, Kyung-Mo Kim, Yoon Jeon, Si-Yeon Lee, and Jihyun Park
- Abstract
CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity. Here, we found that the risk of developing tumors was dependent on Peli1 expression. Peli1 was upregulated in CD8+ T cells among tumor-infiltrating lymphocytes (TIL). In contrast, a deficit of Peli1 enhanced the maintenance and effector function of CD8+ TILs. The development of Peli1-deficient CD8+ TILs prevented T-cell exhaustion and retained the hyperactivated states of T cells to eliminate tumors. We also found that Peli1 directly interacted with protein kinase C-theta (PKCθ), a central kinase in T-cell receptor downstream signal transduction, but whose role in tumor immunology remains unknown. Peli1 inhibited the PKCθ pathway by lysine 48–mediated ubiquitination degradation in CD8+ TILs. In summary, the Peli1–PKCθ signaling axis is a common inhibitory mechanism that prevents antitumor CD8+ T-cell function, and thus targeting Peli1 may be a useful therapeutic strategy for improving cytotoxic T-cell activity.
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- 2023
12. Supplementary Data from The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
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Chang-Woo Lee, Heounjeong Go, Su-Jin Shin, Ho Lee, Dongryeol Ryu, Baeki E. Kang, Joon-Sup Yoon, Eun-Ji Park, Jiwon Ko, Jin-Kwan Lee, Kyung-Mo Kim, Yoon Jeon, Si-Yeon Lee, and Jihyun Park
- Abstract
Supplementary Data from The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
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- 2023
13. Supplementary Figure from The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
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Chang-Woo Lee, Heounjeong Go, Su-Jin Shin, Ho Lee, Dongryeol Ryu, Baeki E. Kang, Joon-Sup Yoon, Eun-Ji Park, Jiwon Ko, Jin-Kwan Lee, Kyung-Mo Kim, Yoon Jeon, Si-Yeon Lee, and Jihyun Park
- Abstract
Supplementary Figure from The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
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- 2023
14. IMPACT OF TRAINEE INVOLVEMENT ON PEDIATRIC ERCP PROCEDURES: RESULTS FROM THE PEDIATRIC ERCP INITIATIVE
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Rekha Gupta, Racha Khalaf, John Morrison, Ernest Amankwah, Wenly Ruan, Douglas S. Fishman, Bradley A. Barth, Quin Y. Liu, Matthew Giefer, Kyung Mo Kim, Mercedes Martinez, Luigi Dall’oglio, Filippo Torroni, Paola De Angelis, Simona Faraci, Sam Bitton, Kulwinder Dua, Steven Werlin, Roberto Gugig, Clifton Huang, Petar Mamula, J. Antonio Quiros, Yuhua Zheng, Travis Piester, Amit Grover, Victor L. Fox, Michael Wilsey, and David M. Troendle
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Pediatrics, Perinatology and Child Health ,Gastroenterology - Published
- 2023
15. Living donor liver transplantation with proximal splenic vein ligation in a pediatric patient with congenital absence of the portal vein
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Jung-Man Namgoong, Shin Hwang, Gil-Chun Park, Suhyeon Ha, Kyung Mo Kim, and Seak Hee Oh
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General Materials Science - Published
- 2022
16. Living donor liver transplantation in an infant patient with progressive familial intrahepatic cholestasis along with hepatocellular carcinoma: a case report
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Kyung Mo Kim, Hyunhee Kwon, Dae Yeon Kim, Seak Hee Oh, Shin Hwang, Jung-Man Namgoong, Chul-Soo Ahn, and Suhyeon Ha
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medicine.medical_specialty ,business.industry ,Internal medicine ,Hepatocellular carcinoma ,medicine ,Progressive familial intrahepatic cholestasis ,business ,Living donor liver transplantation ,medicine.disease ,Gastroenterology - Published
- 2022
17. The Pellino1–PKCθ Signaling Axis Is an Essential Target for Improving Antitumor CD8+ T-lymphocyte Function
- Author
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Jihyun Park, Si-Yeon Lee, Yoon Jeon, Kyung-Mo Kim, Jin-Kwan Lee, Jiwon Ko, Eun-Ji Park, Joon-Sup Yoon, Baeki E. Kang, Dongryeol Ryu, Ho Lee, Su-Jin Shin, Heounjeong Go, and Chang-Woo Lee
- Subjects
Cancer Research ,Lymphocytes, Tumor-Infiltrating ,Protein Kinase C-theta ,Ubiquitin-Protein Ligases ,Immunology ,Nuclear Proteins ,CD8-Positive T-Lymphocytes ,Signal Transduction - Abstract
CD8+ T cells play an important role in the elimination of tumors. However, the underlying mechanisms involved in eliciting and maintaining effector responses in CD8+ T cells remain to be elucidated. Pellino1 (Peli1) is a receptor signal-responsive ubiquitin E3 ligase, which acts as a critical mediator for innate immunity. Here, we found that the risk of developing tumors was dependent on Peli1 expression. Peli1 was upregulated in CD8+ T cells among tumor-infiltrating lymphocytes (TIL). In contrast, a deficit of Peli1 enhanced the maintenance and effector function of CD8+ TILs. The development of Peli1-deficient CD8+ TILs prevented T-cell exhaustion and retained the hyperactivated states of T cells to eliminate tumors. We also found that Peli1 directly interacted with protein kinase C-theta (PKCθ), a central kinase in T-cell receptor downstream signal transduction, but whose role in tumor immunology remains unknown. Peli1 inhibited the PKCθ pathway by lysine 48–mediated ubiquitination degradation in CD8+ TILs. In summary, the Peli1–PKCθ signaling axis is a common inhibitory mechanism that prevents antitumor CD8+ T-cell function, and thus targeting Peli1 may be a useful therapeutic strategy for improving cytotoxic T-cell activity.
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- 2022
18. Liver transplantation in pediatric patients with progressive familial intrahepatic cholestasis: Single center experience of seven cases
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Jung-Man Namgoong, Shin Hwang, Hyunhee Kwon, Suhyeon Ha, Kyung Mo Kim, Seak Hee Oh, and Seung-Mo Hong
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General Materials Science - Abstract
Progressive familial intrahepatic cholestasis (PFIC) is an autosomal recessive inherited disease requiring liver transplantation (LT). The objective of this study was to investigate the clinicopathological features and posttransplant courses of seven LT recipients with PFIC.This was a retrospective single-center study of patients with PFIC who underwent LT from January 2013 to June 2020.Two and five patients were diagnosed with PFIC type 1 and type 2, respectively. For all seven patients, age of PFIC onset was at birth. Jaundice was present in all cases. Mean pretransplant total and direct bilirubin levels were 16.1 ± 8.1 mg/dL and 12.4 ± 6.2 mg/dL, respectively. Median patient age and body weight at LT were 10 months and 7 kg, respectively. Types of donors were mothers of patients in four and deceased donors in three. All five patients with PFIC type 2 recovered uneventfully. One patient each with PFIC type 1 underwent retransplantation due to graft failure or died due to multi-organ failure. Overall graft and patient survival rates at five years were 66.7% and 83.3%, respectively. Bile salt export pump immunohistochemical staining showed normal canalicular expression in two patients with PFIC type 1, focal loss in two patients with PFIC type 2, and total loss in three patients with PFIC type 2.LT is currently the only effective treatment for PFIC-associated end-stage liver diseases. It is mandatory to perform regular follow-up due to the risk of complications including steatohepatitis, especially for patients with PFIC type 1.
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- 2022
19. Detection of shallow wall-thinning of pipes using a flexible interdigital transducer-based scanning laser Doppler vibrometer
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To Kang, Seong-Jin Han, Soonwoo Han, Kyung-Mo Kim, and Dong-Jin Kim
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Mechanical Engineering ,Biophysics - Abstract
Interdigital transducer (IDT)-based scanning laser Doppler vibrometers (SLDVs) have recently been developed to detect shallow defects in plates. An IDT-based SLDV was augmented with Lamb wave frequency fusion capability to enable the imaging of defects across the entire depth of a plate. Dry-coupled IDTs are a type of field-deployable IDT that do not require the attachment of a couplant to the structure. However, this technique is not applicable to the analysis of shallow wall thinning, because IDTs composed of lead zirconium titanate (PZT) cannot be attached to the curved surface of a structure. To address this issue, we developed a new type of IDT—the flexible IDT—that can be bent along the circumferential direction of a pipe. To set the gap spacing of the flexible IDT, the wavenumber sensitivity and minimum distance from the reference mode (MDRM) was calculated, and the S 0 mode is selected to ensure high-wavenumber sensitivity above the threshold of the MDRM. The proposed flexible IDT-based SLDV was tested by using it to visualize the wall thinning on pipes with 4%, 6%, and 20% thinning. The results of this study will contribute toward the development of systems that improve on existing planar laser scanning schemes and enable shallow defect detection in pipes using laser ultrasonics.
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- 2022
20. Analysis of pipe thickness reduction according to pH in FAC facility with In situ ultrasonic measurement real time monitoring
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Dong-Jin Kim, Se-Beom Oh, Kyung Mo Kim, Jong-Yeon Lee, and Jongbeom Kim
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Materials science ,Carbon steel ,System of measurement ,Thickness monitoring ,Flow accelerated corrosion (FAC) ,education ,TK9001-9401 ,Ultrasonic thickness measurement ,engineering.material ,law.invention ,Corrosion ,Nuclear Energy and Engineering ,law ,High-temperature pipe ,Flow-accelerated corrosion ,Fluid dynamics ,engineering ,Waveguide ,Nuclear engineering. Atomic power ,Ultrasonic sensor ,Composite material - Abstract
Flow accelerated corrosion (FAC) is a type of pipe corrosion in which the pipe thickness decreases depending on the fluid flow conditions. In nuclear power plants, FAC mainly occurs in the carbon steel pipes of a secondary system. However, because the temperature of a secondary system pipe is over 150 °C, in situ monitoring using a conventional ultrasonic non-destructive testing method is difficult. In our previous study, we developed a waveguide ultrasonic thickness measurement system. In this study, we applied a waveguide ultrasonic thickness measurement system to monitor the thinning of the pipe according to the change in pH. The Korea Atomic Energy Research Institute installed FAC-proof facilities, enabling the monitoring of internal fluid flow conditions, which were fixed for ~1000 h to analyze the effect of the pH. The measurement system operated without failure for ~3000 h and the pipe thickness was found to be reduced by ~10% at pH 9 compared to that at pH 7. The thickness of the pipe was measured using a microscope after the experiment, and the reliability of the system was confirmed with less than 1% error. This technology is expected to also be applicable to the thickness-reduction monitoring of other high-temperature materials.
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- 2022
21. Pipeline wall thinning rate prediction model based on machine learning
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Dong-Jin Kim, Seong-In Moon, Gyeong-Geun Lee, Kyung Mo Kim, and Yongkyun Yu
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Artificial neural network ,Piping ,Wall thinning ,business.industry ,Computer science ,Pipeline (computing) ,TK9001-9401 ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Process (computing) ,Convolutional neural network ,Construct (python library) ,Machine learning ,computer.software_genre ,Nuclear Energy and Engineering ,Nuclear engineering. Atomic power ,Artificial intelligence ,Flow-accelerated corrosion ,business ,computer ,Predictive modelling - Abstract
Flow-accelerated corrosion (FAC) of carbon steel piping is a significant problem in nuclear power plants. The basic process of FAC is currently understood relatively well; however, the accuracy of prediction models of the wall-thinning rate under an FAC environment is not reliable. Herein, we propose a methodology to construct pipe wall-thinning rate prediction models using artificial neural networks and a convolutional neural network, which is confined to a straight pipe without geometric changes. Furthermore, a methodology to generate training data is proposed to efficiently train the neural network for the development of a machine learning-based FAC prediction model. Consequently, it is concluded that machine learning can be used to construct pipe wall thinning rate prediction models and optimize the number of training datasets for training the machine learning algorithm. The proposed methodology can be applied to efficiently generate a large dataset from an FAC test to develop a wall thinning rate prediction model for a real situation.
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- 2021
22. Wedged-patch venoplasty for graft left portal vein in pediatric living donor liver transplantation
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Shin Hwang, Hyunhee Kwon, Tae-Yong Ha, Seak Hee Oh, Jung-Man Namgoong, and Kyung Mo Kim
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medicine.medical_specialty ,Left portal vein ,business.industry ,Medicine ,General Materials Science ,business ,Living donor liver transplantation ,Surgery - Published
- 2021
23. Portal vein interposition in living donor liver transplantation for a pediatric hepatoblastoma patient with portal vein tumor thrombosis
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Gil-Chun Park, Suhyeon Ha, Kyung Mo Kim, Hyunhee Kwon, Seak Hee Oh, Shin Hwang, and Jung-Man Namgoong
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medicine.medical_specialty ,business.industry ,Portal vein ,Medicine ,Pediatric hepatoblastoma ,General Materials Science ,business ,Living donor liver transplantation ,medicine.disease ,Thrombosis ,Surgery - Published
- 2021
24. Emergency living donor liver transplantation under extracorporeal membrane oxygenation in an infant with biliary atresia-polysplenia syndrome
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Hyunhee Kwon, Seak Hee Oh, Kyung Mo Kim, Gil-Chun Park, Jung-Man Namgoong, and Shin Hwang
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medicine.medical_specialty ,business.industry ,Biliary atresia ,Polysplenia syndrome ,medicine.medical_treatment ,Extracorporeal membrane oxygenation ,Medicine ,General Materials Science ,Living donor liver transplantation ,business ,medicine.disease ,Surgery - Published
- 2021
25. Flow-accelerated corrosion assessment for SA106 and SA335 pipes with elbows and welds
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Sung Hwan Cho, Jong Yeon Lee, Sung-Woo Kim, Se Beom Oh, Jongbeom Kim, Seong-Sik Hwang, Min Jae Choi, Gyeong Geun Lee, Kyung Mo Kim, Dong-Jin Kim, Hong Pyo Kim, and Yun Soo Lim
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Materials science ,020209 energy ,TK9001-9401 ,Metallurgy ,02 engineering and technology ,030218 nuclear medicine & medical imaging ,Volumetric flow rate ,Corrosion ,03 medical and health sciences ,0302 clinical medicine ,Nuclear Energy and Engineering ,Weld ,Pipe corrosion ,Flow-accelerated corrosion ,Elbow ,0202 electrical engineering, electronic engineering, information engineering ,Nuclear engineering. Atomic power ,Straight pipe ,Orifice ,Complicated fluid - Abstract
A FAC (flow-accelerated corrosion) test was performed for a straight pipe composed of the SA335 Gr P22 and SA106 Gr B (SA106-SA335-SA106) types of steel with welds as a function of the flow rate in the range of 7–12 m/s at 150 °C and with DO
- Published
- 2021
26. Medical Management of Pediatric Inflammatory Bowel Disease (PIBD) in the Asia Pacific Region: A Position Paper by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group
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Way Seah, Lee, Katsuhiro, Arai, George, Alex, Suporn, Treepongkaruna, Kyung Mo, Kim, Chee Liang, Choong, Karen Sc, Mercado, Andy, Darma, Anshu, Srivastava, Marion M, Aw, James, Huang, Yen Hsuan, Ni, Rohan, Malik, Pornthep, Tanpowpong, Hong Ngoc, Tran, and Nuthapong, Ukarapol
- Subjects
Hepatology ,Gastroenterology - Abstract
Pediatric inflammatory bowel disease (PIBD) is rising rapidly in many industrialised and affluent areas in the Asia Pacific region. Current available guidelines, mainly from Europe and North America, may not be completely applicable to clinicians caring for children with PIBD in this region due to differences in disease characteristics and regional resources constraints. This position paper is an initiative from the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition (APPSPGHAN) with the aim of providing an up-to-date, evidence-based approach to PIBD in the Asia Pacific region, taking into consideration the unique disease characteristics and financial resources available in this region. A group of pediatric gastroenterologists with special interest in PIBD performed an extensive literature search covering epidemiology, disease characteristics and natural history, management and monitoring. Gastrointestinal infections, including tuberculosis, need to be excluded before diagnosing IBD. In some populations in Asia, the Nudix Hydrolase 15 (NUD15) gene is a better predictor of leukopenia induced by azathioprine than thiopurine-S-methyltransferase (TPMT). The main considerations in the use of biologics in the Asia Pacific region are high cost, ease of access, and potential infectious risk, especially tuberculosis. Conclusion: This position paper provides a useful guide to clinicians in the medical management of children with PIBD in the Asia Pacific region.
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- 2022
27. Technical Outcomes in Pediatric Endoscopic Retrograde Cholangiopancreatography: Data from an International Collaborative
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David M. Troendle, Wenly Ruan, Douglas S. Fishman, Bradley A. Barth, Quin Y. Liu, Matthew Giefer, Kyung Mo Kim, Mercedes Martinez, Luigi Dall’oglio, Filippo Torroni, Paola De Angelis, Simona Faraci, Sam Bitton, Michael Wilsey, Racha Khalaf, Steven Werlin, Kulwinder Dua, Roberto Gugig, Clifton Huang, Petar Mamula, J. Antonio Quiros, Yuhua Zheng, Amit Grover, and Victor L. Fox
- Subjects
Adult ,Cholangiopancreatography, Endoscopic Retrograde ,Adolescent ,Pancreatitis ,Pediatrics, Perinatology and Child Health ,Gastroenterology ,Humans ,Prospective Studies ,Child ,Retrospective Studies ,Catheterization - Abstract
Endoscopic retrograde cholangiopancreatography (ERCP) in adults has been extensively studied through multicenter prospective studies. Similar pediatric studies are lacking. The Pediatric ERCP Database Initiative (PEDI) is a multicenter collaborative aiming to evaluate the indications and technical outcomes in pediatric ERCPs.In this prospective cohort study, data were recorded for pediatric ERCPs performed across 15 centers. A pre-procedure, procedure, 2-week post-procedure follow-up, and adverse event form were completed for each ERCP performed. Univariate and stepwise linear regression was performed to identify factors associated with technically successful procedures and adverse events.A total of 1124 ERCPs were performed on 857 patients from May 1, 2014 to May 1, 2018. The median age was 13.5 years [interquartile range (IQR) 9.0-15.7]. Procedures were technically successful in the majority of cases (90.5%) with success more commonly encountered for procedures with biliary indications [odds ratio (OR) 4.2] and less commonly encountered for native papilla anatomy (OR 0.4) and in children3 years (OR 0.3). Cannulation was more often successful with biliary cannulation (95.9%) compared to pancreatic cannulation via the major papilla (89.6%, P0.0001) or minor papilla (71.2%, P0.0005). The most commonly identified adverse events included post-ERCP pancreatitis (5%), pain not related to post-ERCP pancreatitis (1.8%), and bleeding (1.2%). Risk factors for the development of each were identified.This large prospective study demonstrates that ERCP is reliable and safe in the pediatric population. It highlights the utility of PEDI in evaluating the technical outcomes of pediatric ERCPs and demonstrates the potential of PEDI for future studies in pediatric ERCPs.
- Published
- 2022
28. Measurement Method of Transmission System Transfer Function to Obtain Ultrasonic Displacement Amplitude Incident on Materials
- Author
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Jongbeom Kim, Se-Beom Oh, Hong-Pil Ha, Kyung-Young Jhang, and Kyung Mo Kim
- Subjects
Measurement method ,Materials science ,Acoustics ,Ultrasonic sensor ,Transmission system ,Particle displacement ,Transfer function - Abstract
초음파 비선형 파라미터 β는 재료에 입사된 기본 주파수 성분과 초음파가 재료를 전파하면서 생성된 2차 고조파 성분의 변위 진폭의 비로 정의한다. 초음파 비선형 파라미터 β는 일반적으로 압전형 수신 방법으로 측정되며, 이 방법은 캘리브레이션 측정에서 구한 전달함수를 통해 수신 탐촉자의 전력을 초음파의 변위 진폭으로 변환함으로써 초음파 비선형 파라미터를 측정한다. 하지만, 이렇게 측정된 초음파 비선형 파라미터에는 재료에서 발생한 비선형성뿐만 아니라 측정 시스템에서 발생한 비선형성도 포함되는 문제가 있다. 본 연구에서는 기존의 압전형 수신 방법을 기반으로 재료에 입사되는 기본 주파수 및 2차 고조파 성분의 변위 진폭을 측정하기 위한 송신 시스템 전달함수를 구하는 알고리즘을 제안한다. 제안된 알고리즘으로부터 재료에 입사되는 초음파의 기본파와 2차 고조파 성분의 변위 진폭을 측정할 수 있게 됨으로써 재료의 초음파 비선형 파라미터 측정 신뢰도가 향상될 것으로 기대된다.
- Published
- 2021
29. Dextroplantation of a reduced left lateral section graft in an infant undergoing living donor liver transplantation
- Author
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Gil-Chun Park, Hyunhee Kwon, Seak Hee Oh, Kyung Mo Kim, Yong Jae Kwon, Shin Hwang, and Jung-Man Namgoong
- Subjects
medicine.medical_specialty ,Hepatoblastoma ,Left lateral segment ,business.industry ,Systemic chemotherapy ,medicine.medical_treatment ,Infant ,Case Report ,Pediatric transplantation ,Liver transplantation ,medicine.disease ,Surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Large-for-size graft ,Graft-recipient weight ratio ,medicine ,Abdomen ,General Materials Science ,External iliac vein ,Hepatectomy ,Living donor liver transplantation ,business ,Abdominal wall wound - Abstract
Graft size matching is essential for successful liver transplantation in infant recipients. We present our technique of graft dextroplantation used in an infant who underwent living donor liver transplantation (LDLT) using a reduced left lateral section (LLS) graft. The patient was an 11-month-old female infant weighing 7.8 kg with hepatoblastoma. She was partially responsive to systemic chemotherapy. Thus, LDLT was performed to treat the tumor. The living donor was a 34-year-old mother of the patient. After non-anatomical size reduction, the weight of the reduced LLS graft was 235 g, with a graft-to-recipient weight ratio of 3.0%. Recipient hepatectomy was performed according to the standard procedures of pediatric LDLT. At the beginning of graft implantation, the graft was temporarily placed at the abdomen to determine the implantation location. The graft portal vein was anastomosed with an interposed external iliac vein homograft. As the liver graft was not too large and it was partially accommodated in the right subphrenic fossa, thus the abdominal wall wound was primarily closed. The patient recovered uneventfully. An imaging study revealed deep accommodation of the graft within the right subphrenic fossa. The patient has been doing well for six months without any vascular complications. This case suggests that dextroplantation of a reduced LLS graft can be a useful technical option for LDLT in infant patients.
- Published
- 2021
30. Living donor liver transplantation in a pediatric patient with congenital absence of the portal vein
- Author
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Hyunhee Kwon, Seak Hee Oh, Shin Hwang, Jung-Man Namgoong, Kyung Mo Kim, and Gil-Chun Park
- Subjects
medicine.medical_specialty ,Liver tumor ,business.industry ,medicine.medical_treatment ,Focal nodular hyperplasia ,Splenorenal shunt ,Case Report ,Venous blood ,Hepatocellular adenoma ,Liver transplantation ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Portal vein agenesis ,Interposition graft ,Medicine ,General Materials Science ,Iliac vein homograft ,Hepatectomy ,business ,Vein ,Venous malformation - Abstract
Congenital absence of the portal vein (CAPV) is a rare venous malformation in which mesenteric venous blood drains directly into the systemic circulation. We report a case of pediatric living donor liver transplantation (LDLT) for CAPV combined with focal nodular hyperplasia (FNH) and hepatocellular adenoma. A 9-year-old girl who had been diagnosed with multiple FNH had CAPV. Her blood ammonia level was raised to 137 μg/dL. However, she did not complain of any symptoms. To treat CAPV and FNH, we decided to perform LDLT. The graft was a left liver graft from 39-year-old mother of the patient. Recipient hepatectomy was performed according to standard procedures of pediatric LDLT. Portal vein reconstruction was performed using interposition of an iliac vein homograft conduit to the superior mesenteric vein-splenic vein confluence. The CAPV-associated congenital splenorenal shunt was securely ligated. The pathology report of the explant liver showed a 2 cm-sized hepatocellular adenoma and multiple FNH lesions measuring up to 7.1 cm. The patient recovered uneventfully from the LDLT operation. The reconstructed portal vein was maintained well without any hemodynamic abnormalities. In conclusion, as CAPV patients can have various vascular anomalies, combined vascular anomalies should be thoroughly assessed before and during liver transplantation operation. The most effective reconstruction techniques should be used to achieve satisfactory results following liver transplantation.
- Published
- 2021
31. Pediatric living donor liver transplantation for biliary embryonal rhabdomyosarcoma: a case report of a case showing disease-free survival over 2 years
- Author
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Gil-Chun Park, Suhyeon Ha, Jung-Man Namgoong, Hyunhee Kwon, Shin Hwang, Seak Hee Oh, and Kyung Mo Kim
- Subjects
Transplantation ,Pathology ,medicine.medical_specialty ,Disease free survival ,business.industry ,Immunology ,medicine ,Embryonal rhabdomyosarcoma ,Living donor liver transplantation ,medicine.disease ,business - Published
- 2021
32. Funneling venoplasty for anomalous graft left hepatic vein in living donor liver transplantation using a split left lateral section graft for an infant patient
- Author
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Shin Hwang, Jung-Man Namgoong, Hyunhee Kwon, Tae-Yong Ha, Seak Hee Oh, Young-In Yoon, Yong Jae Kwon, and Kyung Mo Kim
- Subjects
medicine.medical_specialty ,Deceased donor ,business.industry ,medicine.medical_treatment ,Left hepatic vein ,Case Report ,Liver transplantation ,Interposition ,medicine.disease ,Inferior vena cava ,Left lateral section graft ,Surgery ,Transplantation ,Anatomical variation ,medicine.anatomical_structure ,surgical procedures, operative ,medicine.vein ,Normal blood test ,Venoplasty ,medicine ,General Materials Science ,Living donor liver transplantation ,Vein ,business ,Ornithine transcarbamylase deficiency - Abstract
The left lateral section (LLS) can have an unusual variant left hepatic vein (LHV) anatomy. We present a case of customized funneling venoplasty of the graft LHV in a 22-month-old girl diagnosed with ornithine transcarbamylase deficiency undergoing deceased donor liver transplantation (LT) using a split LLS graft. The split LLS graft weighed 350 g, yielding a graft-to-recipient weight ratio of 3.2%. Notably, the graft LHV opening was located at the graft liver cut surface, which was only 1 cm in size and 2 cm away from the cephalad apex of the LLS graft. Since such a variant location of the small LHV opening was unsuitable for direct anastomosis, we performed a funneling venoplasty using an inferior vena cava fragment homograft obtained from the same donor. The graft implantation was performed according to standard procedures of infant split LT. Follow-up imaging studies showed no vascular complications. The patient recovered uneventfully from the LT operation. She had normal blood test findings, including normal ammonia level. She has been doing well for 6 months after the transplantation. In conclusion, our surgical technique using a funneling venoplasty enabled successful reconstruction of the anomalous graft LHV. Our results suggest that individualized reconstruction techniques should be applied to infant patients undergoing LT using a LLS graft with variant types of graft LHV anatomy.
- Published
- 2021
33. Pediatric deceased donor liver transplantation with in situ size reduction for recipient-graft size matching
- Author
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Jung-Man Namgoong, Dong-Hwan Jung, Shin Hwang, Dae Yeon Kim, Tae-Yong Ha, Kyung Mo Kim, Seak Hee Oh, and Gi-Won Song
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Case Report ,Abdominal cavity ,Pediatric transplantation ,Anastomosis ,Liver transplantation ,medicine.disease ,Inferior vena cava ,Surgery ,Left lateral section ,Transplantation ,Liver disease ,medicine.anatomical_structure ,Reduced graft ,medicine.vein ,Biliary atresia ,Large-for-size graft ,Graft-recipient weight ratio ,medicine ,Abdomen ,General Materials Science ,business - Abstract
We present a case of pediatric deceased donor liver transplantation using a reduced whole liver graft in a 25-month-old boy weighing 12.7 kg. After he had undergone Kasai portoenterostomy for biliary atresia, his general condition deteriorated progressively. He was enrolled on the waiting list for liver transplantation with Pediatric End-stage Liver Disease score of 15. The donor was a 51-monthold boy with body weight of 20 kg. The donor-to-recipient body weight ratio was 158%. The liver graft appeared to be larger than the recipient's abdominal cavity. Thus, we planned to do in situ size reduction. Recipient surgery was performed following standard procedures. We performed graft outflow vein reconstruction using a modified piggyback technique like the double inferior vena cava method. Since the portal vein was hypoplastic, a side-to-side anastomosis technique was used. We also performed intraoperative portogram to embolize venous collaterals. After completing the graft implantation, we found that the liver graft was too large to be accommodated within the abdomen. After in situ resection of the left lateral section parenchyma, we successfully performed primary closure of the abdominal wound. This patient experienced episodes of acute rejection. He has been doing well for four years after the transplantation.
- Published
- 2021
34. Recent improvement in survival outcomes and reappraisal of prognostic factors in hepatoblastoma
- Author
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Ho Joon Im, Seak Hee Oh, Hee Mang Yoon, Kyung-Nam Koh, Jung-Man Namgoong, Juhee Shin, Kyung Mo Kim, Se Hoon Choi, Young Ah Cho, Hyery Kim, Sung Han Kang, Jin Kyung Suh, and Dae Yeon Kim
- Subjects
Hepatoblastoma ,Male ,0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Prognostic factor ,medicine.medical_treatment ,Liver transplantation ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Overall survival ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,prognostic factor ,Child ,RC254-282 ,Original Research ,CHIC‐HS ,Retrospective Studies ,PRETEXT ,business.industry ,Liver Neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Clinical Cancer Research ,Infant ,Prognosis ,medicine.disease ,Treatment period ,Liver Transplantation ,Survival Rate ,pediatric ,Treatment Outcome ,030104 developmental biology ,Late period ,Treatment modality ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Background Prognostic factors in hepatoblastoma need to be reevaluated considering the advances in treatment modalities. The study aimed to evaluate current outcomes of hepatoblastoma and reappraise the association of prognostic factors, including pre‐treatment extent of tumor (PRETEXT) stage with annotation factors and Children's Hepatic tumors International Collaboration‐Hepatoblastoma Stratification (CHIC‐HS) system, with survival outcomes. Methods We evaluated 103 consecutive patients with hepatoblastoma retrospectively according to the treatment period based on the introduction of a liver transplantation program. Results The 5‐year overall survival (OS), event‐free survival (EFS), and transplant‐free survival rates were 80.2%, 74.2%, and 61.8%, respectively. EFS and OS were improved significantly from 58.6% to 81.6% (P = 0.024) and from 58.6% to 90.8% (P, Survival rates were significantly improved among children with hepatoblastoma, especially those with advanced PRETEXT stages with positive annotation factors due to advances in surgical techniques and the introduction of effective chemotherapy. Prognostic factors had different clinical implications with evolved treatment modalities.
- Published
- 2021
35. Third retransplantation using a whole liver graft for late graft failure from hepatic vein stent stenosis in a pediatric patient who underwent split liver retransplantation
- Author
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Woo-Hyoung Kang, Yong-Pil Cho, Shin Hwang, Jung-Man Namgoong, Kyung Mo Kim, Sanghoon Kim, Hyunhee Kwon, Young-In Yoon, Seak Hee Oh, and Yong Jae Kwon
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,Liver transplantation ,Inferior vena cava ,Endovascular stenting ,Portal vein stenosis ,Angioplasty ,medicine ,General Materials Science ,cardiovascular diseases ,Vascular insufficiency ,Hepatopulmonary syndrome ,Vein ,Transplantation ,Hepatology ,business.industry ,Gastroenterology ,Stent ,Infant ,Hepatic vein stenosis ,medicine.disease ,Surgery ,Stenosis ,medicine.anatomical_structure ,surgical procedures, operative ,medicine.vein ,cardiovascular system ,business - Abstract
We present a case of third retransplantation using a whole liver graft in a 13-year-old girl who suffered graft failure and hepatopulmonary syndrome following split liver retransplantation with endovascular stenting of the hepatic and portal veins as an infant. She was diagnosed with biliary atresia-polysplenia syndrome, and thus underwent living donor liver transplantation from her mother at 9 months of age. The first liver graft failed due to stenosis of the portal vein. She underwent the second liver transplantation with a split left lateral section graft. Endovascular stenting was performed to the portal vein stenosis 2 months and hepatic vein stenosis 9 months after transplantation. During the next 9 years, 11 sessions of balloon angioplasty for hepatic vein stent stenosis were performed. Ten years after the second transplantation, she underwent third transplantation using a whole liver graft recovered from a 12-year-old-girl. The double inferior vena cava technique was used for outflow vein reconstruction. The graft portal vein was anastomosed with the stent-containing portal vein stump because it was not possible to remove the stent and the inner diameter of the portal vein stent was large enough. An aorto-hepatic jump graft was used for arterial reconstruction. The patient recovered slowly and is doing well for 6 months posttransplant. In conclusion, because stenting of the hepatic vein or portal vein can induce graft failure leading to late retransplantation, we emphasize secure vascular reconstruction to prevent endovascular stenting during LT in infants.
- Published
- 2021
36. A Study on the Development of Filling Materials for Arboretum Surgery with Low-Rise Lightweight Aggregate
- Author
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Sang-Hyuk Kim, Jong Wook Moon, Ki-Moon Kang, Kyung-Mo Kim, Hyeon-Jun Oh, and Seok-Ku Yun
- Subjects
Aggregate (composite) ,Low-rise ,Mining engineering ,Filling materials ,Environmental science - Published
- 2021
37. Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells
- Author
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Jee-Boong Lee, Eun-Ji Park, Jiwon Ko, Heounjeong Go, Seo-Young Koo, Nam Hyemi, Chang-Woo Lee, Jin-Kwan Lee, Tae Jin Kim, Kyung-Mo Kim, and Ho Lee
- Subjects
0301 basic medicine ,Immunology ,Receptors, Antigen, T-Cell ,Models, Biological ,T-Lymphocytes, Regulatory ,Article ,Cell membrane ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Immune Tolerance ,Phosphoprotein Phosphatases ,medicine ,Animals ,Homeostasis ,Immunology and Allergy ,Cell Lineage ,Receptor ,Mice, Knockout ,Phospholipase C gamma ,Chemistry ,Effector ,T-cell receptor ,FOXP3 ,Cell Differentiation ,Forkhead Transcription Factors ,Nuclear Receptor Subfamily 1, Group F, Member 3 ,Inflammatory Bowel Diseases ,Acquired immune system ,Cell biology ,Mice, Inbred C57BL ,030104 developmental biology ,Infectious Diseases ,medicine.anatomical_structure ,Phosphorylation ,Disease Susceptibility ,Protein Binding ,Signal Transduction ,030215 immunology - Abstract
The homeostatic balance between effector T cells and regulatory T cells (Tregs) is crucial for adaptive immunity; however, epigenetic programs that inhibit phosphorylation to regulate Treg development, peripheral expression, and suppressive activity are elusive. Here, we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localizes at the cell membrane. Deletion of Ssu72 in T cells disrupts CD4(+) T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ, which induce CD4(+) T-cell activation and differentiation into effector cell lineages. We also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in patients. Interestingly, Ssu72 forms a complex with PLCγ1, which is an essential effector molecule for T-cell receptor signaling as well as Treg development and function. Ssu72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 induction. Thus, our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.
- Published
- 2021
38. Impact parameter prediction of a simulated metallic loose part using convolutional neural network
- Author
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Joseph Eom, Kyung Mo Kim, Seong-In Moon, Seong-Jin Han, Soonwoo Han, Yongkyun Yu, and To Kang
- Subjects
Computer science ,020209 energy ,02 engineering and technology ,Loose part ,Convolutional neural network ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Machine learning ,0202 electrical engineering, electronic engineering, information engineering ,Finite-element analysis ,Gaussian process ,Artificial neural network ,Series (mathematics) ,business.industry ,Mass estimate ,Deep learning ,lcsh:TK9001-9401 ,Finite element method ,Support vector machine ,Noise ,Impact ,Nuclear Energy and Engineering ,Localization ,symbols ,lcsh:Nuclear engineering. Atomic power ,Artificial intelligence ,business ,Algorithm - Abstract
The detection of unexpected loose parts in the primary coolant system in a nuclear power plant remains an extremely important issue. It is essential to develop a methodology for the localization and mass estimation of loose parts owing to the high prediction error of conventional methods. An effective approach is presented for the localization and mass estimation of a loose part using machine-learning and deep-learning algorithms. First, a methodology was developed to estimate both the impact location and the mass of a loose part at the same times in a real structure in which geometric changes exist. Second, an impact database was constructed through a series of impact finite-element analyses (FEAs). Then, impact parameter prediction modes were generated for localization and mass estimation of a simulated metallic loose part using machine-learning algorithms (artificial neural network, Gaussian process, and support vector machine) and a deep-learning algorithm (convolutional neural network). The usefulness of the methodology was validated through blind tests, and the noise effect of the training data was also investigated. The high performance obtained in this study shows that the proposed methodology using an FEA-based database and deep learning is useful for localization and mass estimation of loose parts on site.
- Published
- 2021
39. Pediatric liver transplantation using a hepatitis B surface antigen-positive donor liver graft for congenital absence of the portal vein
- Author
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Seak Hee Oh, Shin Hwang, Jung-Man Namgoong, Dong-Hwan Jung, Gi-Won Song, Kyung Mo Kim, Dae Yeon Kim, and Tae-Yong Ha
- Subjects
Hepatitis B virus ,HBsAg ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Portacaval shunt ,Venous blood ,030230 surgery ,Liver transplantation ,medicine.disease ,medicine.disease_cause ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Portal hypertension ,030211 gastroenterology & hepatology ,business ,Venous malformation ,Vein - Abstract
Congenital absence of the portal vein (CAPV) is a rare venous malformation in which mesenteric venous blood drains directly into systemic circulation. Herein, we report a case of pediatric deceased donor liver transplantation (DDLT) for symptomatic CAPV with whole liver graft from a hepatitis B surface antigen (HBsAg)-positive donor. A 4-year-old boy suffered from CAPV and secondary portal hypertension. He was also diagnosed with DiGeorge syndrome and heart anomalies. After waiting for 4 months, a 5-year-old donor weighing 19 kg with positive HBsAg was allocated to this 4-year-old pa tient weighing 15 kg. Recipient operation was performed according to the standard pro cedures of pediatric DDLT. Portal vein reconstruction was performed using interposition of a vascular homograft conduit to the superior mesenteric vein-splenic vein confluence. The patient recovered uneventfully from DDLT. He has been administered with lamivu dine to prevent hepatitis B virus infection. This patient has been doing well for 5 years after DDLT without growth retardation. In conclusion, CAPV patients can have various vascular anomalies, thus combined vascular anomalies should be thoroughly assessed before and during liver transplantation operation. The most effective reconstruction techniques should be used to achieve satisfactory results following liver transplantation.
- Published
- 2021
40. Pediatric split liver transplantation for congenital factor X deficiency: first 10-year follow-up of a case with portal vein stenting
- Author
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Dae Yeon Kim, Kyung Mo Kim, Tae-Yong Ha, Seak Hee Oh, Jung-Man Namgoong, Shin Hwang, Dong-Hwan Jung, and Gi-Won Song
- Subjects
medicine.medical_specialty ,business.industry ,Abnormal bleeding ,medicine.medical_treatment ,Portal vein ,Stent ,030230 surgery ,Liver transplantation ,Anastomosis ,Factor X deficiency ,medicine.disease ,Surgery ,03 medical and health sciences ,Stenosis ,0302 clinical medicine ,Split liver transplantation ,medicine ,030211 gastroenterology & hepatology ,business - Abstract
Congenital factor X (FX) deficiency is a rare autosomal-recessive disease that induces bleeding disorder. Herein, we present the 10-year posttransplant course of a pediatric patient who underwent liver transplantation (LT) with portal vein (PV) stenting for cor rection of severe congenital FX deficiency, with focus on long-term maintenance of coagulation function and patency of PV stenting. A 17-month-old infant with recurrent hemorrhagic episodes due to FX deficiency underwent split LT using a left lateral sec tion graft. The graft-recipient weight ratio was 2.2%. The graft implantation procedures were performed by following the standard pediatric split LT procedure. Nevertheless, a wall stent was inserted due to PV anastomotic stenosis on posttransplant day 1. Graft function recovered slowly because of partial parenchyma infarct, and the patient was discharged at 46 days after LT operation. The FX activity started to increase soon after LT and gradually normalized; the coagulation profiles have been maintained well for the past 10 years. The patient has been doing well for the past 10 years after LT without any episodes of abnormal bleeding. Due to the risk of vascular complications owed to PV stenting, life-long follow-up is mandatory with special attention until attainment of com plete physical growth to adolescent and adulthood.
- Published
- 2021
41. Design and operation of the transparent integral effect test facility, URI-LO for nuclear innovation platform
- Author
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In Cheol Bang and Kyung Mo Kim
- Subjects
4th industrial revolution ,Emerging technologies ,Computer science ,020209 energy ,media_common.quotation_subject ,3D printing ,Scaling analysis ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,System safety ,02 engineering and technology ,Integral effect test facility ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,0202 electrical engineering, electronic engineering, information engineering ,Quality (business) ,Nuclear safety ,media_common ,business.industry ,Scale (chemistry) ,lcsh:TK9001-9401 ,Nuclear innovation ,Drone ,Visualization ,Nuclear technology ,Nuclear Energy and Engineering ,Systems engineering ,lcsh:Nuclear engineering. Atomic power ,business - Abstract
Conventional integral effect test facilities were constructed to enable the precise observation of thermal–hydraulic phenomena and reactor behaviors under postulated accident conditions to prove reactor safety. Although these facilities improved the understanding of thermal–hydraulic phenomena and reactor safety, applications of new technologies and their performance tests have been limited owing to the cost and large scale of the facilities. Various nuclear technologies converging 4th industrial revolution technologies such as artificial intelligence, drone, and 3D printing, are being developed to improve plant management strategies. Additionally, new conceptual passive safety systems are being developed to enhance reactor safety. A new integral effect test facility having a noticeable scaling ratio, i.e., the (UNIST reactor innovation loop (URI-LO), is designed and constructed to improve the technical quality of these technologies by performance and feasibility tests. In particular, the URI-LO, which is constructed using a transparent material, enables better visualization and provides physical insights on multidimensional phenomena inside the reactor system. The facility design based on three-level approach is qualitatively validated with preliminary analyses, and its functionality as a test facility is confirmed through a series of experiments. The design feature, design validation, functionality test, and future utilization of the URI-LO are introduced.
- Published
- 2021
42. Research on the Development and Applicability of New Materials for Tree Surgery
- Author
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Hyeon-Jun Oh, Kyung-Mo Kim, Seok-Ku Yun, Jonh-Uk Moon, Ki-Moon Kang, and Sang-Hyuk Kim
- Subjects
Tree (data structure) ,Development (topology) ,Database ,Coal storage ,Computer science ,New materials ,computer.software_genre ,computer - Published
- 2021
43. Multiplex gene targeting in the mouse embryo using a Cas9-Cpf1 hybrid guide RNA
- Author
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Young Hoon Sung, Hye Jin Lee, In-Jeoung Baek, Kyung Mo Kim, Mi Yeon Jeon, Mi Kyoung Ahn, Jeong-Soo Yoon, Seak Hee Oh, Inki Kim, Yeon Ju Jung, and Gyeong-Nam Kim
- Subjects
0301 basic medicine ,Biophysics ,Biology ,Biochemistry ,Cell Line ,Mice ,03 medical and health sciences ,0302 clinical medicine ,CRISPR-Associated Protein 9 ,Animals ,Multiplex ,Guide RNA ,Molecular Biology ,Gene ,Gene knockout ,Gene Editing ,Trans-activating crRNA ,Mice, Inbred ICR ,Messenger RNA ,Cas9 ,Gene targeting ,Cell Biology ,Embryo, Mammalian ,Endonucleases ,Cell biology ,Mice, Inbred C57BL ,030104 developmental biology ,030220 oncology & carcinogenesis ,Gene Targeting ,RNA, Guide, Kinetoplastida - Abstract
CRISPR-Cas systems, including Cas9 and Cpf1 (Cas12a), are promising tools for generating gene knockout mouse models. Unlike Cas9, Cpf1 can generate multiple crRNAs from a single concatemeric crRNA precursor, which is favorable for multiplex gene editing. Recently, a hybrid guide RNA (hgRNA) system employing both Cas9 and Cpf1 was developed for multiplex gene editing. As the crRNA of Cpf1 was linked to the 3' end of the sgRNA for Cas9, it can be split into separate guide RNAs by Cpf1. To examine whether this Cas9-Cpf1 hybrid system is suitable for multiplex gene knockouts in the mouse embryo, we generated an hgRNA that simultaneously targets the mouse Il10ra gene by Cas9 and mouse Dr3 (or Tnfrsf25, death receptor3) gene by Cpf1. The expression of hgRNA from a single promoter induced significant indels at each gene in cultured mouse cells upon the co-expression of both Cas9 and Cpf1. Interestingly, the hgRNA exhibited comparable Cas9-mediated indel activity without Cpf1 expression. Similarly, when the hgRNA was co-microinjected with both Cas9 and Cpf1 mRNAs into mouse zygotes at the pronuclear stage, founder mice were generated harboring mutations in both the Il10ra and Dr3 genes. However, when Cas9 mRNA was used alone without Cpf1 mRNA, the mouse Il10ra gene targeting was significantly decreased. These results indicate that the hgRNA system is a possible tool for multiplex gene targeting in the mouse embryo.
- Published
- 2021
44. Predictive Prenatal Diagnosis for Infantile-onset Inflammatory Bowel Disease Because of Interleukin-10 Signalling Defects
- Author
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I Williams, Ruth Horn, Daniel Kotlarz, Ying Huang, Galina Ling, Holm H. Uhlig, Alexio M. Muise, Y Zhang, L. de Ridder, Scott B. Snapper, Dror S. Shouval, Kyung Mo Kim, Hirokazu Kanegane, B Wu, C Lei, Z Ye, Christoph Klein, W Hu, Baruch Yerushalmi, Neil Shah, and Pediatrics
- Subjects
Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Prenatal diagnosis ,Inflammatory bowel disease ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,030225 pediatrics ,medicine ,Humans ,Age of Onset ,Child ,Retrospective Studies ,Genetic testing ,Fetus ,In vitro fertilisation ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Inflammatory Bowel Diseases ,medicine.disease ,Interleukin-10 ,Interleukin 10 ,Pediatrics, Perinatology and Child Health ,Amniocentesis ,Female ,030211 gastroenterology & hepatology ,business - Abstract
OBJECTIVES: Advances in genetic technologies provide opportunities for patient care and ethical challenges. Clinical care of patients with rare Mendelian disorders is often at the forefront of those developments. Whereas in classical polygenic inflammatory bowel disease the predictive value of genetic variants is very low, predictive prenatal genetic diagnosis can inform families at high risk of severe genetic disorders. Patients with IL10 signalling defects due to pathogenic variants in IL10RA, Il10RB and IL10 develop severe infantile onset inflammatory bowel disease that is completely penetrant and has a high morbidity and substantial mortality despite treatment. METHODS: We performed a survey among tertiary specialist paediatric centers of 10 countries on the utilisation of predictive prenatal genetic diagnosis in IL-10 signalling defects. We retrospectively report prenatal genetics in a series of 8 families. RESULTS: International variation in legislation, guidelines, expert opinion, as well as cultural and religious background of families and clinicians results in variable utilization of preimplantation and prenatal genetic testing for IL-10 signalling defects. Eleven referrals for prenatal diagnosis for IL-10 signalling defects were identified across four countries. We report on 8 families who underwent prenatal preimplantation monogenic testing after in vitro fertilization (n = 2) and/or by amniocentesis/chorion villus sampling (n = 6). A genetic diagnosis was established in one foetus and excluded in 7 foetuses (all IL10RA variants). CONCLUSIONS: Prenatal genetic testing for IL10R-defects is feasible, yet the legal and ethical considerations are complex and controversial. In some countries, predictive genetics for IL-10-related signalling defects is entering clinical practice.
- Published
- 2021
45. Ability of Pelvic Magnetic Resonance Imaging to Predict Clinical Course of Perianal Fistula in Paediatric Crohn’s Disease Patients
- Author
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Ah Young Jung, Seak Hee Oh, Jin Seong Lee, Dae Yeon Kim, Seo Hee Kim, Hee Mang Yoon, Pyeong Hwa Kim, Young Ah Cho, Jung-Man Namgoong, and Kyung Mo Kim
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Fistula ,Disease ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Internal medicine ,Republic of Korea ,Epidemiology ,Humans ,Rectal Fistula ,Medicine ,Retrospective Studies ,Subclinical infection ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,030211 gastroenterology & hepatology ,business - Abstract
Background and Aims Evidence is limited regarding clinical course and magnetic resonance imaging [MRI] features of perianal fistula [PAF] in Korean children with Crohn’s disease [CD]. We investigated MRI features of PAF and associations with long-term outcomes. Methods We retrospectively analysed 243 patients with pelvic MRI for diagnosis of CD. Incidence of clinically evident PAF at diagnosis was determined, as were the proportions of patients with clinical failure [failure to achieve fistula healing within 1 year] and recurrence [new/recurrent PAF after fistula healing within 1 year]. Associations between outcomes and MRI features, specified in modified Van Assche index and MAGNIFI-CD, were evaluated. Associations between later development of clinically evident PAF and subclinical PAF detected on MRI at diagnosis were evaluated. Results Among 243 included patients, 108 [44.4%] and 76 [31.3%] had clinically evident and subclinical PAF at diagnosis, respectively; 66.4% of the patients with clinically evident PAF achieved fistula healing within 1 year, and 32.7% of those patients developed recurrence. Fistula length and dominant features of the tracts were associated with clinical failure, and fistula length was associated with recurrence. Clinically evident PAF developed in 17.0% of the patients without clinically evident PAF at diagnosis. We did not find statistically significant association between subclinical PAF and later development of clinically evident PAF [adjusted hazard ratio, 2.438; p = 0.15]. Conclusions A considerable proportion of Korean paediatric CD patients had clinically evident and subclinical PAF. Fistula length and dominant feature of the tract on MRI are useful predictors of outcomes.
- Published
- 2021
46. Unification venoplasty of the outflow hepatic vein for laparoscopically harvested left liver grafts in pediatric living donor liver transplantation
- Author
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Yong Jae Kwon, Gil-Chun Park, Hwui-Dong Cho, Ki-Hun Kim, Hyunhee Kwon, Seak Hee Oh, Kyung Mo Kim, Shin Hwang, and Jung-Man Namgoong
- Subjects
Hepatoblastoma ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Left liver ,medicine.disease ,Tumor recurrence ,Surgery ,Septoplasty ,Stenosis ,surgical procedures, operative ,medicine.anatomical_structure ,Vein patch ,medicine ,Vein ,Living donor liver transplantation ,business - Abstract
Laparoscopically harvested left liver (LL) grafts have drawbacks with respect to the size and shape of graft hepatic vein orifices. We present two cases of pediatric living donor liver transplantation (LDLT) using laparoscopically harvested LL grafts and describe re fined surgical techniques for graft hepatic vein venoplasty. The first case was a boy aged 4 years and 5 months, with hepatoblastoma. The donor was his 35-year-old mother, and LL graft weighed 315 g. Two separate openings of the graft at the left hepatic vein (LHV) and middle hepatic vein (MHV) were unified through septotomy and septoplasty, and cryopreserved vein homograft patch was attached. Standard procedures of LDLT were performed. This patient recovered uneventfully and has been doing well for 4 years with out tumor recurrence. The second case was a 6-year-old girl with ornithine transcarbam ylase deficiency. The donor was her 35-year-old mother, and the LL graft weighed 310 g. Two separate openings of graft MHV, with segment III and segment II veins, were unified through septoplasty, and vein patch was attached. Standard procedures of LDLT were performed. This patient has been doing well for 4 years. In conclusion, separate graft he patic vein openings are a drawback of laparoscopically harvested LL grafts, which thus require unification venoplasty of customized design individually tailored for LL graft and pediatric recipient.
- Published
- 2020
47. Whole liver deceased donor liver transplantation for pediatric recipients: single-center experience for 20 years
- Author
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Jung-Man Namgoong, Shin Hwang, Dae-Yeon Kim, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Kyung Mo Kim, and Seak Hee Oh
- Abstract
We investigated the incidence and outcomes of pediatric deceased donor liver transplantation (DDLT) using whole liver grafts in a high-volume liver transplantation (LT) center.The study was a retrospective single-center analysis of whole LT in pediatric recipients. The study period was set as 20 years between January 2000 and December 2019. We defined pediatric recipients and donors to be aged ≤18 years.During the study period, there were 98 cases of pediatric DDLT, and 34 patients (34.7%) received whole liver grafts. The age range of the deceased donors was 3 months to 56 years and that of pediatric recipients was 7 months to 17 years. Common primary diseases for LT were biliary atresia in 13, acute liver failure in four, Wilson disease in four, congenital portal vein agenesis in three, and genetic metabolic diseases in three. Pediatric-to-pediatric and adult-to-pediatric whole LTs were 22 (64.7%) and 12 (35.3%), respectively. A good correlation was noted between the donor and the recipient's body weight, and the recipient's body weight and allograft's weight. Graft and overall patient survival rates were 91.2% and 91.2% at 1 year, 88.0% and 88.0% at 3 years, and 88.0% and 88.0% at 5 years, respectively.The results of this study revealed that Korean Network for Organ Sharing (KONOS) regulations with donor-recipient body weight matching exhibited good performance. Considering the reciprocal trades of liver organs among pediatric and adult donors and recipients, it is necessary to establish a policy for pediatric donor liver grafts to pediatric recipients on a priority basis.
- Published
- 2020
48. Pediatric split liver transplantation using a hyperreduced left lateral segment graft in an infant weighing 4 kg
- Author
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Jung-Man Namgoong, Shin Hwang, Dae-Yeon Kim, Gi-Won Song, Chul-Soo Ahn, Kyung Mo Kim, and Seak Hee Oh
- Subjects
medicine.medical_specialty ,business.industry ,Abdomen closure ,medicine.medical_treatment ,Progressive familial intrahepatic cholestasis ,medicine.disease ,Surgery ,Transplantation ,Abdominal wall ,medicine.anatomical_structure ,Split liver transplantation ,Medicine ,Lateral segment ,Liver function ,Hepatectomy ,business - Abstract
We present a case of successful split liver transplantation (LT) using a hyperreduced left lateral segment (LLS) graft in a 106-day-old female infant patient weighing 4 kg. The patient was diagnosed with progressive familial intrahepatic cholestasis. Her general condition and liver function deteriorated progressively and she was finally allocated for a split LT under status 1. The deceased donor was a 20-year-old female weighing 63.7 kg. We performed in situ liver splitting and in situ size reduction sequen tially. The weight of the hyperreduced LLS graft was 225 g, with a graft-recipient weight ratio of 5.5%. We performed recipient hepatectomy and graft implantation according to the standard procedures for pediatric living-donor LT. Since the graft was too large for primary abdomen closure, the abdominal wall was closed in three stages to make a prosthetic silo, temporary closure with a xenograft sheet, and final primary repair over 2 weeks. The patient has been doing well for more than 6 years after transplantation. In conclusion, split LT using a hyperreduced LLS graft can be a useful option for treating small infants. However, large-for-size graft-related problems, particularly in terms of graft thickness, still remain to be solved.
- Published
- 2020
49. Effective energy management design of spent fuel dry storage based on hybrid control <scp>rod‐heat</scp> pipe
- Author
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In Cheol Bang and Kyung Mo Kim
- Subjects
Heat pipe ,Fuel Technology ,Materials science ,Dry storage ,Nuclear Energy and Engineering ,Effective energy ,Waste management ,Renewable Energy, Sustainability and the Environment ,Control rod ,Energy Engineering and Power Technology ,Thermosiphon ,Spent nuclear fuel - Published
- 2020
50. Living donor liver retransplantation for primary non-function of liver graft following multivisceral transplantation in a pediatric patient
- Author
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Shin Hwang, Ki-Hun Kim, Yu Jeong Cho, Jung-Man Namgoong, Chul-Soo Ahn, Dae Yeon Kim, Kyung Mo Kim, Hyunhee Kwon, Seak Hee Oh, and Yong Jae Kwon
- Subjects
medicine.medical_specialty ,business.industry ,Living donor liver transplantation ,Stomach ,medicine.medical_treatment ,Case Report ,Liver transplantation ,Organ transplantation ,Surgery ,Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,Primary non-function ,Duodenum ,medicine ,Multivisceral transplantation ,General Materials Science ,Hepatectomy ,business ,Pancreas ,Splanchnic ,Portocaval shunt - Abstract
Multivisceral organ transplantation (MVOT) includes transplantation of three or more abdominal organs, generally including the small bowel, duodenum, stomach, liver, pancreas, and colon. We here presented the detailed procedures of repeat living donor liver transplantation for primary non-function of the first liver graft following MVOT in a pediatric patient. A 6-year-old girl with chronic intestinal pseudo-obstruction underwent MVOT with 5-year-old donor organs. However, the primary non-function of the liver graft developed, and an emergency living donor liver transplantation operation using a left lateral section graft was performed on the third day after MVOT. The donor was the patient's father. Portal flow interruption induced ischemic congestion of the whole small bowel, thus we used a series of porto- caval shunt to reduce the risk of ischemic splanchnic congestion during recipient hepatectomy and graft implantation. Other surgical procedures were the same as the standardized procedures for left liver graft implantation. The graft-recipient weight ratio was 2.15. The patient was managed conservatively for 3 months and discharged in an improved condition at 4 months after MVOT. She finally passed away at 22 months after MVOT. We think that our experience will be helpful for surgeons to cope with portal vein clamping-associated splanchnic congestion during liver transplantation and other abdominal surgeries.
- Published
- 2020
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