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Supplemental material, sj-docx-2-fas-10.1177_19386400221079490 for Validity and Reliability of the American Orthopaedic Foot and Ankle Society Score for the English-Literate Singapore Population With Hallux Valgus by Chin Chuen Tan, Andrew Arjun Sayampanathan, Yu Heng Kwan, William Yeo, Inderjeet Singh Rikhraj and Nicholas Eng Meng Yeo in Foot & Ankle Specialist

Supplemental material, sj-docx-2-fas-10.1177_19386400221079490 for Validity and Reliability of the American Orthopaedic Foot and Ankle Society Score for the English-Literate Singapore Population With Hallux Valgus by Chin Chuen Tan, Andrew Arjun Sayampanathan, Yu Heng Kwan, William Yeo, Inderjeet Singh Rikhraj and Nicholas Eng Meng Yeo in Foot & Ankle Specialist

Supplemental material, sj-docx-3-fas-10.1177_19386400221079490 for Validity and Reliability of the American Orthopaedic Foot and Ankle Society Score for the English-Literate Singapore Population With Hallux Valgus by Chin Chuen Tan, Andrew Arjun Sayampanathan, Yu Heng Kwan, William Yeo, Inderjeet Singh Rikhraj and Nicholas Eng Meng Yeo in Foot & Ankle Specialist

Background Deprescribing is effective and safe in reducing polypharmacy among the elderly. However, the impact of deprescribing rounds remain unclear in Asian settings. Hence, we conducted this study. Methods An open label randomised controlled trial was conducted on patients of 65 years and above, under rehabilitation or subacute care and with prespecified medications from a Singapore rehabilitation hospital. They were randomised using a computer generated sequence. The intervention consisted of weekly multidisciplinary team-led deprescribing rounds (using five steps of deprescribing) and usual care. The control had only usual care. The primary outcome is the percentage change in total daily dose (TDD) from baseline upon discharge, while the secondary outcomes are the total number of medicine, total daily cost and TDD up to day 28 postdischarge, overall side-effect rates, rounding time and the challenges. Efficacy outcomes were analysed using intention-to-treat while other outcomes were analysed as per protocol. Results 260 patients were randomised and 253 were analysed after excluding dropouts (female: 57.3%; median age: 76 years). Baseline characteristics were largely similar in both groups. The intervention arm (n = 126) experienced a greater reduction of TDD on discharge [Median (IQR): − 19.62% (− 34.38, 0.00%) versus 0.00% (− 12.00, 6.82%); p p = 0.009) though death and hospitalisation rates were similar. The median rounding time was 7.09 min per patient and challenges include the inconvenience in assembling the multidisciplinary team. Conclusion Deprescribing rounds can safely reduce TDD of medicine upon discharge compared to usual care in a Singaporean rehabilitation hospital. Trial registration This study is first registered at Clinicaltrials.gov (protocol number: NCT03713112) on 19/10/2018 and the protocol can be accessed on https://www.clinicaltrials.gov.

Additional file 2. Details of included studies

Supplemental material, sj-docx-1-dst-10.1177_19322968211056917 for Evaluation of Machine Learning Methods Developed for Prediction of Diabetes Complications: A Systematic Review by Kuo Ren Tan, Jun Jie Benjamin Seng, Yu Heng Kwan, Ying Jie Chen, Sueziani Binte Zainudin, Dionne Hui Fang Loh, Nan Liu and Lian Leng Low in Journal of Diabetes Science and Technology

Additional file 1. Details of full search strategy

Additional file 4. Advantages and disadvantages of population segmentation methods [14, 181]

Additional file 5. Definitions of criterion used for evaluation of population segmentation outcomes [16, 181]

Additional file 1: Supplementary Table 1. Levels of activity of patients with axial spondyloarthritis with age-, gender-matched controls.

Additional file 3 Funding sources for included studies (n = 148)

Supplemental material, Appendix_12_Funnel_plots_v2 for Risk of malignancies in patients with spondyloarthritis treated with biologics compared with those treated with non-biologics: a systematic review and meta-analysis by Yu Heng Kwan, Ka Keat Lim, Warren Fong, Hendra Goh, Linkai Ng, Benjamin Haaland, Jie Kie Phang, Lian Leng Low, Joo Guan Yeo, Feng Huang, Ying Ying Leung, Julian Thumboo and Truls Østbye in Therapeutic Advances in Musculoskeletal Disease

Supplemental material, PRISMA_Checklist_for_Submission_TAMD_v2 for Risk of malignancies in patients with spondyloarthritis treated with biologics compared with those treated with non-biologics: a systematic review and meta-analysis by Yu Heng Kwan, Ka Keat Lim, Warren Fong, Hendra Goh, Linkai Ng, Benjamin Haaland, Jie Kie Phang, Lian Leng Low, Joo Guan Yeo, Feng Huang, Ying Ying Leung, Julian Thumboo and Truls Østbye in Therapeutic Advances in Musculoskeletal Disease

Supplemental material, Appendix_10_Distribution_of_Covariables for Risk of malignancies in patients with spondyloarthritis treated with biologics compared with those treated with non-biologics: a systematic review and meta-analysis by Yu Heng Kwan, Ka Keat Lim, Warren Fong, Hendra Goh, Linkai Ng, Benjamin Haaland, Jie Kie Phang, Lian Leng Low, Joo Guan Yeo, Feng Huang, Ying Ying Leung, Julian Thumboo and Truls Østbye in Therapeutic Advances in Musculoskeletal Disease

Additional file 1.

Additional file 2.

Additional file 1: Supplementary table 1. Wilcoxon signed-rank test results comparing responses from round 1 and round 2 of the Delphi survey.

Supplemental material, Appendix_1_Search_Terms_v5 for Risk of malignancies in patients with spondyloarthritis treated with biologics compared with those treated with non-biologics: a systematic review and meta-analysis by Yu Heng Kwan, Ka Keat Lim, Warren Fong, Hendra Goh, Linkai Ng, Benjamin Haaland, Jie Kie Phang, Lian Leng Low, Joo Guan Yeo, Feng Huang, Ying Ying Leung, Julian Thumboo and Truls Østbye in Therapeutic Advances in Musculoskeletal Disease

Objective: The aim of this study was to assess the attitudes ofpatients in Singapore suffering from chronic disorders towardsself-management of their disease.Materials and Methods: A cross-sectional study wasconducted using a questionnaire administered by 2nd yearPharmacy students. Patients with at least one of theseconditions (hypertension, diabetes and/orhypercholesterolemia) in the outpatient pharmacy of a tertiaryhospital were interviewed. Data collected was analysed usingnon-parametric statistics (Chi-square and Spearman’s rho) toassess the association between demographic variables andpatient self-management habits.Results: A total of 211 surveys were collected. More than 50%of patients did not seek further knowledge of their medicalcondition (52.1%). Most of them also could not remembernames of the medications (55.5%). This was largely due to acombination of English illiteracy (26%) and difficultmedication names (25%). Only 18% of patients possessedcompetent self-management habits. An association wasdemonstrated between competent self-management habits andincome (p

Foot care education is an important strategy in reducing lower limb complications. There is evidence that contemporary communication approaches can improve patient education outcomes. To inform the potential of such methods in diabetic foot education, we trialled a collaborative approach in patient education counselling in a podiatry clinic. We conducted a single-blind pragmatic randomised controlled trial on 52 diabetes patients who had an active foot ulcer. Participants were randomised to either collaborative education or traditional didactic education. Outcomes on knowledge and self-care behaviours were collected via a pre and post study questionnaire (max score: 75). The study ended at 12 weeks or when the wound healed prior. 42 (80.7%) participants completed the study. The collaborative patient education group had a significant increase in score post-study (38.8 ± 8.5) compared to pre-study (32.8 ± 6.9; P