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Aging is one of the major risk factors for most neurodegenerative disorders including Parkinson's disease (PD). More than 10 million people are affected with PD worldwide. One of the predominant factors accountable for progression of PD pathology could be enhanced accumulation of senescent cells in the brain with the progress of age. Recent investigations have highlighted that senescent cells can ignite PD pathology via increased oxidative stress and neuroinflammation. Senolytics are agents that kill senescent cells. This review mainly focuses on understanding the pathological connection between senescence and PD, with emphasis on some of the recent advances made in the area of senolytics and their evolution to potential clinical candidates for future pharmaceuticals against PD.

Nanoemulsions (NMs) are one of the most important colloidal dispersion systems that are primarily used to improve the solubility of poorly water soluble drugs. The main objectives of this study were, first, to prepare an NM loaded with fenofibrate using a high shear homogenization technique and, second, to study the effect of variable using a central composite design. Twenty batches of fenofibrate-loaded NM formulations were prepared. The formed NMs were subjected to droplet size analysis, zeta potential, entrapment efficiency, pH, dilution, polydispersity index, transmission electron microscopy (TEM), Fourier transform infrared spectrophotometry, differential scanning calorimetry (DSC), and in vitro drug release study. Analysis of variance was used for entrapment efficiency data to study the fitness and significance of the design. The NM-7 batch formulation demonstrated maximum entrapment efficiency (81.82%) with lowest droplet size (72.28 nm), and was thus chosen as the optimized batch. TEM analysis revealed that the NM was well dispersed with droplet sizes

In the present study, ZnO/Ni composites have been studied for its dielectric and microwave absorption behavior as a function of x (Ni/Zn-acetate ratio) viz. x=0.08, 0.12, and 0.16 in the frequency range of 2-18 GHz. The hydrothermal method was successfully employed for the synthesis of single-phase Ni and ZnO particles. The phase confirmation was done using the X-ray diffraction technique and Maud refinement was successfully carried out using Maud software for the determination of crystallite size and the lattice parameters of pure Ni, pure ZnO, and x=0.16 sample. The inclusion of Ni in ZnO results in the improvement of complex permittivity values as compared to pure ZnO. However, there is not much significant enhancement in the complex permeability values. The microwave absorption characteristics are completely dependent on the dielectric properties of the composite materials. Ni incorporated ZnO composites show improvement in the microwave absorption characteristic as compared to pure ZnO. The improvement in microwave absorption behavior of the ZnO/Ni composite system may be ascribed to various mechanisms viz. dipole polarization, interfacial polarization, conduction loss, and impedance matching which synergistically acts to enhance the microwave absorption. A minimum reflection loss of -12.86 dB corresponding to > 90% absorption of incident microwave energy was observed for x=0.16 sample at a frequency of 17.47 GHz corresponding to 3 mm absorber thickness as compared to pure ZnO having a minimum reflection loss of -1.5 dB at the same absorber thickness.

COVID-19 or SARS CoV-2 is a worldwide public health emergency. The first case of COVID-19 was described in Wuhan, China in December, 2019 and within a short time the infection had spread quickly to the rest of China and then the world. The COVID-19 pandemic has had a huge impact on patients who do not have COVID-19 but other diseases like cancer, diabetes, and many more non-communicable diseases; their care is compromised because of the pandemic. COVID-19 also poses a work-related health risk for healthcare workers who are treating patients with COVID-19, and many have themselves become infected. Healthcare workers involved in diagnosing and treating patients with COVID-19 should be evaluated for stress, anxiety and depression.

In the present study, effect of dietary supplementation of fish oil during the non-breeding season on the reproductive performance of the goats was investigated. Experimental does were fed an isocaloric diet of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) rich fish (FO; n=12) or palm oil (PO; n=12) for 71 days. Periodical ovarian scanning for 21 days from the day of supplementation (day 0) confirmed acyclicity. Estrus induction was done by intra-vaginal progesterone (P4) sponge for 14 days from day 22 to 35 of supplementation. Dietary FO did not affect serum P4 throughout the period of supplementation. Ovarian scanning studies revealed that neither the number of surface follicles nor the diameter of largest surface follicle was significantly different between the groups at any point of supplementation. Similarly, the concentration of serum estradiol (E2) and P4 on the day of induced estrus was comparable between the groups. However, supplementation of FO decreased the PGFM significantly on day 16–18 post-estrus. In conclusion, supplementation of EPA and DHA rich FO for about 10 weeks inhibited the endometrial PGF2α production during the luteolytic window at induced estrus; however, it did not improve the ovarian function and fertility in the seasonally acyclic goat.

ispartof: Thorax vol:53 issue:11 pages:915-918 status: published

The paper investigates the influence of corporate social responsibility (CSR) on Innovative Work Behavior (IWB). The mediating role of passion and organizational commitment is investigated for understanding the effect of CSR on companies' performances by adopting a behavioral perspective. Based on the exploratory literature review conducted during the period from 1990 to 2020 and the content analysis method, we explore possible relationships among CSR, human capital, relational capital, and innovative work behaviors. Building upon the evidence from the literature review, a set of propositions have been defined for supporting both researchers and practitioners in enhancing the potential contribution of perceived CSR to improve companies' performance by adopting IWBs. The paper enriches ongoing debate about CSR's influence on companies' performances investigating the pivotal role of perceptions about CSR practices in influencing IWBs within the business field.