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The paper considers issues of the Barents Sea shelf geodynamic evolution and influence of basement geologic structural processes on seabed morphology in their interaction. The obtained data have made possible to assume that the Norwegian-Mezenskaya rift system, Voronin graben, St. Anne and Victoria grabens were formed at the expense of the lithosphere stretching processes, but the Vostochno-Barentsevomorskaya basin and Medvezinsko-Edzinskaya area of depressions developed on the initial stage of lithosphere plate evolution due to collision of several island arcs and now all of them are outliers of the ancient oceanic crust. The technique of morphostructural analysis developed by the authors has allowed solve the inverse problem, and under morphological approach split all largest depressions on two main genetic types that confirm received geodynamic conclusion

The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of SNP285C was 6-8% across European populations except for Finns (1.2%) and Saami (0.3%). The incidence decreased towards the Middle-East and Eastern Russia, and SNP285C was absent among Han Chinese, Mongolians and African Americans. Interhaplotype variation analyses estimated SNP285C to have originated about 14,700 years ago (95% CI: 8,300 – 33,300). Both this estimate and the geographical distribution suggest SNP285C to have arisen after the separation between Caucasians and modern day East Asians (17,000 - 40,000 years ago). We observed a strong inverse correlation (r = -0.805; p < 0.001) between the percentage of SNP309G alleles harboring SNP285C and the MAF for SNP309G itself across different populations suggesting selection and environmental adaptation with respect to MDM2 expression in recent human evolution. In conclusion, we found SNP285C to be a pan-Caucasian variant. Ethnic variation regarding distribution of SNP285C needs to be taken into account when assessing the impact of MDM2 SNPs on cancer risk. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.