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The problem of attenuation and sound speed of bubbly media has remained partially unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation and sound speed of a bubbly medium are not available. Our theoretical understanding of the problem is limited to linear or semi-linear theoretical models, which are not accurate in the regime of large amplitude bubble oscillations. Here, by controlling the size of the lipid coated bubbles (mean diameter of ~5.4um), we report the first time observation and characterization of the simultaneous pressure dependence of sound speed and attenuation in bubbly water below, at and above MBs resonance (frequency range between 1-3MHz). With increasing acoustic pressure (between 12.5-100kPa), the frequency of the attenuation and sound speed peaks decreases while maximum and minimum amplitudes of the sound speed increase. We propose a nonlinear model for the estimation of the pressure dependent sound speed and attenuation with good agreement with the experiments. The model calculations are validated by comparing with the linear and semi-linear models predictions. One of the major challenges of the previously developed models is the significant overestimation of the attenuation at the bubble resonance at higher void fractions (e.g. 0.005). We addressed this problem by incorporating bubble-bubble interactions and comparing the results to experiments. Influence of the bubble-bubble interactions increases with increasing pressure. Within the examined exposure parameters, we numerically show that, even for low void fractions (e.g. 5.1*10-6) with increasing pressure the sound speed may become 4 times higher than the sound speed in the non-bubbly medium., Comment: arXiv admin note: text overlap with arXiv:1811.07788

The pressure threshold for 1/2 order subharmonic (SH) emissions and period doubling during the oscillations of ultrasonically excited bubbles is thought to be minimum when the bubble is sonicated with twice its resonance frequency (fr). This estimate is based on studies that simplified or neglected the effects of thermal damping. In this work, the nonlinear dynamics of ultrasonically excited bubbles is investigated accounting for the thermal dissipation. Results are visualized using bifurcation diagrams as a function of pressure. Here we show that, and depending on the gas, the pressure threshold for 1/2 order SHs can be minimum at a frequency between 0.5fr

Acoustic waves are dissipated when they pass through bubbly media. Dissipation by bubbles takes place through thermal damping (Td), radiation damping (Rd) and damping due to the friction of the liquid (Ld) and friction of the coating (Cd). Knowledge of the contributions of the Td, Rd, Ld and Cd during nonlinear bubble oscillations will help in optimizing bubble and ultrasound exposure parameters for the relevant applications by maximizing a desirable parameter. In this work we investigate the mechanisms of dissipation in bubble oscillations and their contribution to the total damping (Wtotal) in various nonlinear regimes. By using bifurcation analysis, we have classified nonlinear dynamics of bubbles that are sonicated with their 3rd superharmonic (SuH) and 2nd SuH resonance frequency (fr), pressure dependent resonance frequency (PDfr), fr, subharmonic (SH) resonance (fsh=2fr), pressure dependent SH resonance (PDfsh) and 1/3 order SH resonance. The corresponding Td, Rd, Ld, Cd, Wtotal, scattering to dissipation ratio (STDR), maximum wall velocity and maximum back-scattered pressure from non-destructive oscillations of bubbles were calculated and analyzed using the bifurcation diagrams. We classified different regimes of dissipation and provided parameter regions in which a particular parameter of interest (e.g. Rd) can be enhanced. Afterwards enhanced bubble activity is linked to some relevant applications in ultrasound. This paper represents the first comprehensive analysis of the nonlinear oscillations regimes and the corresponding damping mechanisms.

The acoustic bubble is an example of a highly nonlinear system which is the building block of several applications and phenomena ranging from underwater acoustics to sonochemistry and medicine. Nonlinear behavior of bubbles, and most importantly 1/2 order subharmonics (SH), are used to increase the contrast to tissue ratio (CTR) in diagnostic ultrasound (US) and to monitor bubble mediated therapeutic US. It is shown experimentally and numerically that when bubbles are sonicated with their SH resonance frequency (fsh=2fr where fr is the linear resonance frequency), SHs are generated at the lowest excitation pressure. SHs then increase rapidly with pressure increase and reach an upper limit of the achievable SH signal strength. Numerous studies have investigated the pressure threshold of SH oscillations; however, conditions to enhance the saturation level of SHs has not been investigated. In this paper nonlinear dynamics of bubbles excited by frequencies in the range of fr, Comment: arXiv admin note: text overlap with arXiv:1909.02694

Exploiting the full potential of MBs for applications requires a good understanding of their complex dynamics. Improved understanding of MB oscillations can lead to further enhancement in optimizing their efficacy in many applications and also invent new ones. Previous studies have predominantly addressed the behavior of a single isolated MB in an infinite liquid domain, whereas most applications employ MBs in clusters. Oscillating MBs have been shown to generate secondary pressure waves that modify the dynamics of the MBs in their proximity. A modified Keller-Miksis equation is used to account for inter-bubble interactions. The oscillatory dynamics of each MB within clusters was computed by numerically solving the resulting system of coupled nonlinear second order differential equations. Frequency response analysis and bifurcation diagrams were employed to track the dynamics of interacting MBs. Here we investigate the dynamics of polydisperse MB clusters over a wide range of acoustic and geometric parameters. An emergent collective behavior within bubble clusters was observed whereby individual dynamics of smaller bubbles were suppressed resulting in a collective behavior dominated by the dynamics of the largest MB within the cluster. The emergent dynamics of smaller MBs within bubble clusters can be characterized by constructive and destructive inter-bubble interactions. In constructive interactions, the radial oscillations of smaller bubbles matched those of the largest MB and their oscillations are amplified. In destructive interactions, the oscillations of smaller bubbles are suppressed so that their oscillations match those of the largest MB. Furthermore, a special case of constructive interactions is presented where dominant MB (largest) can force smaller MBs into period doubling and subharmonic oscillations.

Period doubling route to chaos is one of the well-known characteristics of nonlinear oscillators. A bubble is a highly nonlinear oscillator that exists in various phenomena and applications ranging from material science and underwater acoustics to medical ultrasound. The occurrence of period doubling (PD) in the oscillations of the bubbles is concomitant with the generation of 1/2 order subharmonics (SHs). SH oscillations are used to monitor the bubble activity and are employed as a measure of stable cavitation. As bubbles are intravascular contrast agents, SH oscillations are used in diagnostic ultrasound to increase the contrast of the blood vessels to the tissue. Despite the importance of PD in a bubble oscillator, the dynamical behavior of the bubble during stable SH and ultra-harmonic (UH) oscillations have not thoroughly studied yet. In this work, through applying a comprehensive bifurcation method, we study the nonlinear radial oscillations of the bubble oscillator as a function of ultrasound driving pressure. The frequency of the driving force is chosen as the linear resonance frequency (fr) and linear SH resonance frequency (fsh=2fr) of the bubble. Results show that, when the bubble is sonicated with 2fr, PD doubling occurrence is more likely to result in non-destructive oscillations. The evolution of the bubble stable P2 dynamics forms the shape of a bow-tie for bubbles with an initial diameter of 740nm and above. When f=2fr, the phase portrait of the P2 attractor is distinctly different from a P2 attractor when f=fr, and SH component of the backscattered pressure is maximum. When sonicated by 2fr, due to lower oscillation amplitude and gentler bubble collapse, the bubble can sustain stable P2 oscillations for a longer duration and over a broader range of applied acoustic pressure.

Acoustically excited bubbles are involved in a wide range of phenomena and applications ranging from oceanography to sonoluminescence; they have applications in chemistry, medical imaging, and therapeutic ultrasound. The complexity of bubble dynamics and the limited understanding of their behavior restricts the exploration of their full potential. The bubble oscillator is a highly nonlinear system, which makes it difficult to generate a comprehensive understanding of its oscillatory behavior. One method used to investigate such complex dynamical systems is the bifurcation analysis. Numerous investigations have employed the method of bifurcation diagrams to study the effect of different control parameters on the bubble behavior. These studies, however, focused mainly on investigating the subharmonic (SH) and chaotic oscillations of the bubbles. Super-harmonic (SuH) and ultra-harmonic (UH) bubble oscillations remain under-investigated. One reason is that the conventional method used for generating bifurcation diagrams cannot reliably identify features that are responsible for the identification of SuH and UH oscillations. Additionally, the conventional method cannot distinguish between the UHs and SHs. We introduce a simple procedure for the generation of bifurcation diagrams to address this shortcoming. This method selects the maxima of the bubble oscillatory response and plots them alongside the traditional bifurcation points for the corresponding control parameter. Through applying this method, the oscillatory behavior of the bubble oscillator is analyzed, and stable SuH and UH bubble oscillations are investigated. Based on this new analysis, the conditions for the generation and amplification of UH and SuH regimes are discussed.

Results of the measurements of sound speed and attenuation in a bubbly medium are reported. Monodisperse bubble solutions are sonicated with broadband ultrasound pulses with pressure amplitudes ranging between 12.5-100 kPa. Fundamental relationships between the frequency dependent attenuation, sound speed and pressure are established. A new model for the estimation of sound speed and attenuation is derived that incorporates the effect of nonlinear bubble oscillations on the wave propagation in the bubbly media. Model predictions are in good agreement with experimental results.

High frequency ultrasound backscattered signals (20 - 60 MHz) from normal and apoptotic cell pellets differ in their backscatter intensity, and analyzing these signals could assist in the non-invasive monitoring of cancer therapy. In this work, the reflection coefficients of the lattice prediction error filter are used as feature set for parametric analysis and signal classification. The ultrasound (US) backscattered signal databases consisted of combinations of treated (apoptotic) and untreated (normal) cells mixed in different proportions. A 40 MHz commercial ultrasound imaging system was used. A classification accuracy of 97-100% for normal and apoptotic signals were obtained with a model order 15. The positive results ascertain that the reflection coefficient is a potential tool for analyzing biomedical signals such as US backscattered signals