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2. Impact of Abdominal Aortic Calcification After Major Hepatobiliary Pancreatic Surgery: A Retrospective Cohort Study

Author

Yuki, Imaoka, Masahiro, Ohira, Koki, Sato, Kouki, Imaoka, Tomoaki, Bekki, Ryosuke, Nakano, Shintaro, Kuroda, Hiroyuki, Tahara, Kentaro, Ide, Tsuyoshi, Kobayashi, Yuka, Tanaka, and Hideki, Ohdan

Subjects
Biliary Tract Surgical Procedures, Cancer Research, Oncology, Arteriosclerosis, Anastomosis, Surgical, Humans, Hepatectomy, General Medicine, Retrospective Studies
Abstract

The rate of postoperative morbidity after major hepatobiliary pancreatic (HBP) surgery is estimated to be high. We hypothesized that the frailty and insufficient blood supply of organs caused by arteriosclerosis may lead to increased severity of postoperative complications. The aim of this study was to clarify the relationship between abdominal aortic calcification (AAC) and severity of major HBP surgery postoperative complications.A total of 322 major HBP surgeries were performed in Hiroshima University Hospital, Japan from January 2010 to March 2018. The records of 214 patients were retrospectively analyzed to include those with hepatectomy in two or more segments. These included donor hepatectomy, hepatectomy with biliary tract reconstruction, and pancreaticoduodenectomy. We compared the baseline AAC levels (cut-off; 1,000 mmThe high-AAC (N=71) group had significantly increased incidence rates of surgical site infections and a higher CCI, even after propensity matching. Multivariate analysis revealed that a higher AAC was an independent risk factor of severe postoperative complications (CCI ≥40) (OR=10.21, p0.01).An increased AAC has a corresponding increase in postoperative complication severity after major HBP surgery. Careful anastomosis and infection control are required to prevent the progression of severe postoperative complications among high-AAC patients.

Published
2022

6. Prediction of anastomotic leakage after left-sided colorectal cancer surgery: a pilot study utilizing quantitative near-infrared spectroscopy

Author

Hisaaki Yoshinaka, Yuji Takakura, Hiroyuki Egi, Wataru Shimizu, Yusuke Sumi, Shoichiro Mukai, Masatoshi Kochi, Kazuhiro Taguchi, Ikki Nakashima, Shintaro Akabane, Koki Sato, Minoru Hattori, and Hideki Ohdan

Subjects
Spectroscopy, Near-Infrared, Anastomosis, Surgical, Humans, Anastomotic Leak, Pilot Projects, Surgery, Prospective Studies, General Medicine, Colorectal Neoplasms
Abstract

Anastomotic leakage (AL) occurs with some frequency in all types of colorectal cancer surgery and is associated with increased morbidity, mortality and recurrence rates. Complications might be prevented by monitoring intra-operative bowel perfusion at the anastomotic site. A pilot study concerning the objective and quantitative measurement of tissue perfusion by monitoring regional tissue saturation of oxygen (rSOThis study evaluated the ability of the INVOS™ system to predict AL after left-sided colorectal cancer surgery. rSOAmong 73 patients, 6 (8.2%) experienced AL. The rSOMonitoring the rSO

Published
2022

7. Impact of abdominal aortic calcification on clinical outcomes following initial hepatectomy for hepatocellular carcinoma: A retrospective cohort study

Author

Shintaro Kuroda, Kouki Imaoka, Kentaro Ide, Koki Sato, Yuki Imaoka, Tsuyoshi Kobayashi, Yuka Tanaka, Hiroyuki Tahara, Hideki Ohdan, and Masahiro Ohira

Subjects
medicine.medical_specialty, RD1-811, medicine.medical_treatment, RC799-869, Gastroenterology, calcification, Internal medicine, medicine, HCC, business.industry, Retrospective cohort study, Original Articles, biochemical phenomena, metabolism, and nutrition, Diseases of the digestive system. Gastroenterology, medicine.disease, bacterial infections and mycoses, carbohydrates (lipids), Hepatocellular carcinoma, Abdominal aortic calcification, bacteria, Original Article, Surgery, prognosis, Hepatectomy, business, Calcification
Abstract

Aim The clinical impact of abdominal aortic calcification (AAC) in patients who undergo hepatectomy for hepatocellular carcinoma (HCC) is unknown. Methods To evaluate the impact of AAC on clinical outcomes, we analyzed 203 patients who underwent hepatectomy for HCC between 2010 and 2013. Results Kaplan–Meier survival curve analysis showed significantly worse overall survival (OS) in the high AAC group than in the low AAC group. The recurrence‐free survival (RFS) was also significantly worse in the high AAC group. In the multivariate analysis, high AAC (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.24–5.09; P = .01) was an independent risk factor for poor OS after hepatectomy for HCC. High AAC was also an independent risk factor for poor RFS (HR, 1.69; 95% CI, 1.04–2.76; P = .04). Conclusions Abdominal aortic calcification had a strong relationship with poor OS and RFS after hepatectomy for HCC. We suggest that AAC had a relationship with smoking and diabetes; therefore, AAC could reflect a surrogate for older age, worse health status, and inflammatory score., Kaplan–Meier survival curve analysis showed significantly worse overall survival in the high abdominal aortic calcification (AAC) group than in the low AAC group.

Published
2022

9. The characteristics of residual pneumoperitoneum after laparoscopic colorectal surgery

Author

Sotaro Fukuhara, Shintaro Akabane, Kazuhiro Taguchi, Hisaaki Yoshinaka, Hiroyuki Egi, Hideki Ohdan, Minoru Hattori, Yoshifumi Teraoka, Koki Sato, Yusuke Sumi, Yuji Takakura, Masatoshi Kochi, Wataru Shimizu, and Ikki Nakashima

Subjects
Laparoscopic surgery, medicine.medical_specialty, Univariate analysis, Percutaneous, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Anastomotic Leak, Retrospective cohort study, General Medicine, Anastomosis, medicine.disease, Colorectal surgery, Surgery, body regions, Pneumoperitoneum, medicine, Humans, Laparoscopy, business, Colorectal Surgery, Digestive System Surgical Procedures, Retrospective Studies
Abstract

INTRODUCTION Despite the popularity of laparoscopic surgery, it remains unclear whether residual pneumoperitoneum influences the patient's postoperative course. This study aimed to evaluate the characteristics of residual pneumoperitoneum. METHODS This retrospective study included 201 Japanese patients who had undergone elective laparoscopic colorectal surgery. The patients were divided into groups, with and without anastomotic failure; the non-anastomotic failure group was further divided into subgroups, with and without residual pneumoperitoneum. Patient characteristics were compared between the various groups. RESULTS The group with residual pneumoperitoneum included 57 patients (30.3%). Percutaneous drainage was required for one patient with residual pneumoperitoneum. Univariate analyses revealed that residual pneumoperitoneum was associated with low values for body mass index (BMI) and subcutaneous fat area (SFA). Furthermore, relative to the group with anastomotic failure, the group without anastomotic failure but with residual pneumoperitoneum had lower values for inflammatory markers. CONCLUSION Low BMI and SFA values were identified as risk factors for residual pneumoperitoneum. Inflammatory markers may be useful as indicators for avoiding emergent surgery when it is difficult to differentiate between asymptomatic residual pneumoperitoneum and free air related to anastomotic failure.

Published
2021

11. Adoptive immunotherapy with natural killer cells from peripheral blood CD34

Author

Masahiro, Ohira, Tsuyoshi, Kobayashi, Yuka, Tanaka, Yuki, Imaoka, Koki, Sato, Koki, Imaoka, Ryosuke, Nakano, Marlen, Doskali, Jinlian, Piao, Mayuna, Nakamura, Tetsumi, Yoshida, Tatsuo, Ichinohe, Reo, Kawano, Kenichi, Yoshimura, Keiko, Ueda, Natsuko, Tamura, Taizo, Hirata, Michio, Imamura, Hiroshi, Aikata, Naoki, Tanimine, Shintaro, Kuroda, Hiroyuki, Tahara, Kentaro, Ide, and Hideki, Ohdan

Subjects
Killer Cells, Natural, Carcinoma, Hepatocellular, Clinical Trials, Phase I as Topic, Stem Cells, Liver Neoplasms, Humans, Hepatectomy, Neoplasm Recurrence, Local, Neoplastic Cells, Circulating, Immunotherapy, Adoptive, Cell Adhesion Molecules
Abstract

Hepatocellular carcinoma (HCC) remains a major clinical problem as more than half of these cases recur after radical resection. Natural killer (NK) cells are at the forefront of the innate immune system and attack microcarcinomas and circulating tumour cells. The objective of this study was to evaluate the feasibility and toxicity of peripheral blood CD34This is an open-label, single-arm, single-centre phase I study. Patients who have undergone initial hepatectomy for HCC with three or more risk factors for recurrence (≥10 ng/mL of Alpha fetoprotein (AFP), ≥360 mAU/mL of PIVKA-II, multiple tumours and ≥3 peripheral blood circulating tumour cells) will be enrolled and be treated with three peripheral blood CD34Ethical approval of the trial was obtained from the Certified Committee for Regenerative Medicine Hiroshima University in Japan. The trial results will be shared with the scientific community at international conferences and by publication in a peer-reviewed journal.jRCTb060200020.

Published
2022

13. A phase I/II study of adoptive immunotherapy using donor liver graft-derived natural killer cells to prevent bloodstream infection after liver transplantation: a study protocol

Author

Masahiro Ohira, Yuki Imaoka, Koki Sato, Koki Imaoka, Ryosuke Nakano, Naoki Tanimine, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, and Hideki Ohdan

Abstract

Background Bloodstream infections (BSIs) are among the most lethal complications of liver transplantation (LT). Natural killer (NK) cells are an important component of innate immunity and play an essential role in infection and cancer. Adoptive transfer of activated NK cells has the potential to decrease post-LT infections, including BSIs. Methods In this prospective, single-center, interventional, single-arm, historical control, phase I/II study, 37 LT recipients will enroll. The patient will receive a single infusion of donor liver-derived NK cells 3−5 days after LT. Discussion The primary endpoint is the incidence of BSIs during the first month after LT. Secondary endpoints include overall survival, adverse events, immunological responses, hepatocellular or de novo malignancy, and incidence of infectious disease. Trial registration This study was prospectively registered with UMIN000019183 (https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000022074) on November 1, 2015 and jRCTa060190036 on February 27, 2020.

Published
2022

14. Selective Stimulation of a Target Neuron in Micropatterned Neuronal Circuits Using a Pair of Needle Electrodes

Author

Ayumi Hirano-Iwata, Soichiro Oguma, Koki Sato, Honoka Takahashi, Mihoko Ishida, Hideaki Yamamoto, Takashi Tanii, Kouhei Hattori, Hekiru Kurakake, Junko Imai, and Takuya Hashimoto

Subjects
Technology, Chemistry, Physical and theoretical chemistry, QD450-801, neuron, medicine.anatomical_structure, Neuronal circuits, nervous system, ltspice, Selective stimulation, Electrode, Electrochemistry, medicine, two needle electrodes, selective stimulation, Neuron, Neuroscience
Abstract

Neurostimulation is an essential technique to trigger and modulate the spatiotemporal activity of local neuronal circuits. Current stimulation methods have a trade-off relationship among aiming precision, temporal resolution, and noninvasiveness, making it difficult to stimulate and monitor a single target neuron for a long term. Here, we show that a method using two needle electrodes in combination of micropatterning techniques provides new possibilities for targeting and stimulating a single neuron selectively. Results of physiological experiments as well as analog circuit simulation reveal that two needle electrodes can stimulate a target neuron selectively by placing the two needle electrodes in proximity to and to straddle the target neuron, and that the steepness of voltage applied to two needle electrodes is important for the target neuron to fire at a low voltage. The proposed method enables a noninvasive stimulation suitable for measuring long-term activity of local neuronal circuits.

Published
2021

16. Tumor budding as a predictive marker for 5-fluorouracil response in adjuvant-treated stage III colorectal cancer

Author

Kazuhiro Sentani, Wataru Yasui, Shintaro Akabane, Koki Sato, Masatoshi Kochi, Yuji Takakura, Kazuhiro Taguchi, Hiroyuki Egi, Wataru Shimizu, Hideki Ohdan, Ikki Nakashima, and Minoru Hattori

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Tumor budding, Surgical oncology, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Stage (cooking), Aged, Neoplasm Staging, Retrospective Studies, Chemotherapy, Predictive marker, business.industry, Hematology, General Medicine, Prognosis, medicine.disease, Oxaliplatin, 030104 developmental biology, Chemotherapy, Adjuvant, Fluorouracil, 030220 oncology & carcinogenesis, Surgery, Neoplasm Recurrence, Local, Colorectal Neoplasms, business, medicine.drug
Abstract

Tumor budding (TB) has been described as an adverse prognostic marker for operable colorectal cancer (CRC); however, a limited number of studies have demonstrated the prognostic significance of TB in patients with drug therapy. This study was conducted to determine the predictive power of TB in stage III CRC patients who received adjuvant chemotherapy. We retrospectively collected clinicopathological data including TB of 237 stage III colorectal cancer patients at Hiroshima University Hospital between July 1, 2006 and June 31, 2019. Differential disease-free survival (DFS) was investigated according to TB status. This study included 237 patients with a median age of 67 years, comprising patients who underwent surgery alone (n = 65), 5-fluorouracil (5-FU) monotherapy (n = 129), and oxaliplatin-based chemotherapy (n = 43). Overall, 81 patients developed disease recurrence, and 33 patients died of cancer-related causes. The TB status was categorized into two groups: 99 with low budding (

Published
2021

18. Relationship between outcomes and relative dose intensity of lenvatinib treatment in patients with advanced hepatocellular carcinoma

Author

Yuji Kondo, Eriko Goto, Mayuko Kondo, Masatoshi Akamatsu, Hideo Yoshida, Koki Sato, Yukihiro Koike, Takamasa Ohki, Shinpei Sato, Shuntaro Obi, and Takahisa Sato

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Advanced hepatocellular carcinoma, medicine.drug_class, Tyrosine kinase inhibitor, Tyrosine-kinase inhibitor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Overall survival, Chemotherapy, In patient, lcsh:RC799-869, Response rate (survey), Hepatology, business.industry, Gastroenterology, Retrospective cohort study, medicine.disease, Dose intensity, 030104 developmental biology, chemistry, Hepatocellular carcinoma, Lenvatinib (LEN), lcsh:Diseases of the digestive system. Gastroenterology, 030211 gastroenterology & hepatology, business, Lenvatinib, Relative dose intensity (RDI)
Abstract

Background and aims: Lenvatinib (LEN) is a newly developed tyrosine kinase inhibitor, and is approved as a first-line treatment for advanced hepatocellular carcinoma (HCC) in Japan. This retrospective multi-center study investigated the effect of the relative dose intensity (RDI) of LEN on response rate, progression-free survival (PFS), and overall survival (OS). Methods: This retrospective study enrolled 123 patients with advanced HCC who were treated with LEN at six hospitals in Japan between March 2018 and December 2019. These patients were divided into two groups: RDI ≥70% (RDI 70 group, N = 70) or RDI

Published
2020

19. Efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma treatment in patients aged ≥80 years

Author

Koki Sato, Takamasa Ohki, Nobuo Toda, Mayuko Kondo, Kyohei Tsuchiya, and Kazumi Tagawa

Subjects
0301 basic medicine, medicine.medical_specialty, Percutaneous, Multivariate analysis, Radiofrequency ablation, Locoregional therapy, Gastroenterology, law.invention, Therapy naive, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Propensity score matching, medicine, In patient, Alanine aminotransferase, Hepatocellular carcinoma (HCC), lcsh:RC799-869, Prothrombin time, Hepatology, medicine.diagnostic_test, business.industry, Radiofrequency ablation (RFA), medicine.disease, Elderly patients, 030104 developmental biology, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, lcsh:Diseases of the digestive system. Gastroenterology, business
Abstract

Background: Although radiofrequency ablation (RFA) is a minimally invasive treatment for early-stage hepatocellular carcinoma (HCC), it remains unclear whether RFA achieves favorable outcomes in patients aged ≥80 years. This study aimed to determine the efficacy and safety of RFA for HCC in patients aged ≥80 years. Methods: A total of 512 naïve patients with HCC who had undergone RFA from January 2001 to December 2016 were enrolled. They were categorized into the ≥80-year-old group and the control group (aged

Published
2020

20. Effects of water transport on deuterium isotope separation during polymer electrolyte membrane water electrolysis

Author

Hisayoshi Matsushima, Takahide Haneda, Koki Sato, Risako Tanii, Kenji Harada, and Mikito Ueda

Subjects
Heavy water, Electrolysis, Water transport, Materials science, Hydrogen, Electrolysis of water, Renewable Energy, Sustainability and the Environment, Energy Engineering and Power Technology, chemistry.chemical_element, 02 engineering and technology, Electrolyte, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Isotope separation, law.invention, Anode, chemistry.chemical_compound, Fuel Technology, chemistry, Chemical engineering, law, 0210 nano-technology
Abstract

Water electrolysis is essential for producing hydrogen as an energy source for society. The development of polymer electrolyte membrane water electrolysis (PEMWE) has also raised the potential for new applications of electrolysis technologies. In this study, we demonstrate deuterium (D) isotope separation where pure water containing heavy water is supplied to the anode of a PEMWE. The D separation was evaluated by measuring the concentration in the drained water and in the generated hydrogen gas. The D separation was measured at several of stoichiometry numbers of feed water, λ, which was ratio of the theoretical water consumption to water feed. Notably, at the same stoichiometry, the D separation depended on the volume of the water feed to the anode of the cell and current density. This effect might be explained by complex water transport behavior governed by electro-osmotic flow and back diffusion across the concentration gradient.

Published
2020

21. Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells

Author

Yuki Imaoka, Koki Sato, Masahiro Ohira, Kouki Imaoka, Takuya Yano, Ryosuke Nakano, Yuka Tanaka, and Hideki Ohdan

Subjects
Killer Cells, Natural, TNF-Related Apoptosis-Inducing Ligand, Mice, Hepatology, Portal Vein, Hypertension, Portal, Liver Neoplasms, Animals, Antineoplastic Agents, Interleukin-33, Proto-Oncogene Proteins c-akt
Abstract

The effects of acute portal hypertension (PHT), which is reported as poor prognostic factors in patients with hepatocellular carcinoma, are not well known on the liver immune system, including natural killer (NK) cells. The aim of this study, therefore, was to investigate how acute PHT influences the functions and characteristics of liver-resident NK (lr-NK) cells using an acute PHT mouse model. Acute PHT decreased the number of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL

Published
2022

22. Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study

Author

Yuki Imaoka, Masahiro Ohira, Koki Sato, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Yuka Tanaka, Reo Kawano, and Hideki Ohdan

Subjects
medicine.medical_specialty, medicine.medical_treatment, Splenectomy, 030230 surgery, Liver transplantation, Transplant Donors, Living donor, Gastroenterology, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Internal medicine, Living Donors, Humans, Medicine, Proportional Hazards Models, Retrospective Studies, Transplantation, business.industry, Graft Survival, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, Liver Transplantation, carbohydrates (lipids), Treatment Outcome, Hepatocellular carcinoma, Abdominal aortic calcification, bacteria, 030211 gastroenterology & hepatology, business, Living donor liver transplantation
Abstract

Background and aims Abdominal aortic calcification (AAC) was reported as a poor prognostic factor among liver transplantation. However, donor AAC is not enough discussed. We analyzed the impact of the donor AAC level on graft function on outcomes following living donor liver transplantation (LDLT). A total of 133 consecutive patients who had undergone LDLT were divided into two groups (non-AAC group and AAC group) according to their donor AAC level by plain computed tomography. Results The rate of postoperative biliary complications (BC) was significantly higher in AAC group (N=17) than in non-AAC group (N=116) (HR, 2.77; 95% CI, 1.32-5.83; p=.0008). The Cox proportional-hazards regression model revealed that donor AAC (HR, 4.15; 95% CI, 1.93-8.97; p = .0003) and right lobe graft (HR, 2.81; 95% CI, 1.41-5.61; p=.003) increased the risk of BC. Conversely, splenectomy (HR, 0.39; 95% CI, 0.16-0.92; p=.03) decreased the risk of BC after LDLT independently. The long-term survival was also significantly worse in AAC group than in non-AAC group. (HR, 2.25; 95% CI, 1.04-4.89; p=.04) CONCLUSION: Donor AAC was an independent prognostic factor for BC among patients undergoing LDLT. Although further investigations are needed to verify our results, the levels of donor AAC could be a useful tool to identify the risks of BC, and predict better outcomes following LDLT.

Published
2020

23. Impact of Adverse Events on the Progression-Free Survival of Patients with Advanced Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Retrospective Study

Author

Koki Sato, Shuntaro Obi, Shinpei Sato, Yuji Kondo, Takamasa Ohki, Hideo Yoshida, Takahisa Sato, Masatoshi Akamatsu, Eriko Goto, Yukihiro Koike, and Mayuko Kondo

Subjects
medicine.medical_specialty, lcsh:RS1-441, 030226 pharmacology & pharmacy, Gastroenterology, lcsh:Pharmacy and materia medica, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacotherapy, Internal medicine, medicine, Pharmacology (medical), 030212 general & internal medicine, Progression-free survival, Original Research Article, Adverse effect, business.industry, Hazard ratio, lcsh:RM1-950, Retrospective cohort study, medicine.disease, Confidence interval, lcsh:Therapeutics. Pharmacology, chemistry, Hepatocellular carcinoma, business, Lenvatinib
Abstract

Background and Objective Experience of the use of lenvatinib (LEN) in the clinical setting remains limited. We conducted this study to elucidate the factors associated with progression-free survival (PFS) in patients with advanced HCC treated with LEN. Methods In this multicenter retrospective study, we analyzed data on patient characteristics, treatment outcomes, and adverse events (AEs) for 77 patients with advanced hepatocellular carcinoma (HCC). We also analyzed PFS and factors that influence PFS. Results The response rate to LEN was 29.9% and the disease control rate was 77.9%. Patients who achieved relative dose intensities of more than 70% had better outcomes (response rate 45.2% vs. 11.4%, P

Published
2020

26. Adoptive immunotherapy with natural killer cells from peripheral blood CD34+stem cells to prevent hepatocellular carcinoma recurrence after curative hepatectomy: a study protocol for an open-label, single-arm phase I study

Author

Masahiro Ohira, Tsuyoshi Kobayashi, Yuka Tanaka, Yuki Imaoka, Koki Sato, Koki Imaoka, Ryosuke Nakano, Marlen Doskali, Jinlian Piao, Mayuna Nakamura, Tetsumi Yoshida, Tatsuo Ichinohe, Reo Kawano, Kenichi Yoshimura, Keiko Ueda, Natsuko Tamura, Taizo Hirata, Michio Imamura, Hiroshi Aikata, Naoki Tanimine, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, and Hideki Ohdan

Subjects
General Medicine
Abstract

IntroductionHepatocellular carcinoma (HCC) remains a major clinical problem as more than half of these cases recur after radical resection. Natural killer (NK) cells are at the forefront of the innate immune system and attack microcarcinomas and circulating tumour cells. The objective of this study was to evaluate the feasibility and toxicity of peripheral blood CD34+stem cell-derived NK cell infusion after radical hepatectomy for HCC.Methods and analysisThis is an open-label, single-arm, single-centre phase I study. Patients who have undergone initial hepatectomy for HCC with three or more risk factors for recurrence (≥10 ng/mL of Alpha fetoprotein (AFP), ≥360 mAU/mL of PIVKA-II, multiple tumours and ≥3 peripheral blood circulating tumour cells) will be enrolled and be treated with three peripheral blood CD34+stem cell-derived NK cell infusions every 3 months. The primary endpoint will be safety assessment including the type and severity of adverse events, frequency of occurrence and duration of occurrence. The secondary endpoints will include survival, effect of immune response and clinical laboratory test results.Ethics and disseminationEthical approval of the trial was obtained from the Certified Committee for Regenerative Medicine Hiroshima University in Japan. The trial results will be shared with the scientific community at international conferences and by publication in a peer-reviewed journal.Trial registration numberjRCTb060200020.

Published
2022

28. Study on the cosmic ray intensity variation using scintillation counters for air shower observation

Author

Ryuji Takeishi, Daiki Shinto, Priti Shah, Michiyuki Chikawa, Ryo Nakamura, Shingo Kawana, Rasha Abbasi, Masahiro Takeda, Ken Honda, Takashi Sako, M. Ohnishi, Taichi Inadomi, Kinya Hibino, William Hanlon, Sergey Troitsky, Fumiya Shibata, Saori Kasami, G. Furlich, Takaaki Ishii, Aoi Iwasaki, Taka Tomida, Jyunsei Chiba, Dongsu Ryu, Fugo Yoshida, J. Remington, Ben Stokes, Min Hyo Kim, Koki Sato, Zach Zundel, Matt Potts, Kenta Yashiro, Hirokazu Iwakura, Kengo Sano, Federico R. Urban, Nobuyuki Sakurai, Y. Takagi, D. C. Rodriguez, HangBae Kim, Vladim Kuzmin, Hideki Tanaka, Shinnosuke Kurisu, Keitaro Fujita, Shigeharu Udo, Hisono Tokuno, Hideaki Shimodaira, Hyoming Jeong, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Naoaki Hayashida, Tatsunobu Shibata, H. Oda, Ivan Kharuk, Ryuhei Arimura, S. Kawakami, Stanton Thomas, Akitoshi Oshima, Ryota Fujiwara, Toshiyuki Nonaka, Ryo Higuchi, Shunsuke Ozawa, Yuta Tanoue, Ricardo Gonzalez, Yoshiki Tsunesada, Daisuke Ikeda, Naoto Sakaki, Katsuaki Kasahara, Pierre Sokolsky, Yuya Oku, Arata Nakazawa, Katsumasa Kawata, Charlie Jui, Motoki Hayashi, Shigehiro Nagataki, Oleg Kalashev, Tiffany Wong, Samuel Blake, Hirotaka Ito, Shoichi Ogio, Yana Zhezher, Hiroyuki Sagawa, Kei Nakai, BayarJon Paul Lubsandorzhiev, Sang Woo Kim, Masaki Fukushima, Fumio Kakimoto, M. Yamamoto, Yuichiro Tameda, Heungsu Shin, Mayuko Minamino, K. Yamazaki, Kozo Fujisue, Jeremy Smith, Tareq Abu-Zayyad, John Matthews, Tsubasa Yoshioka, Koichi Tanaka, J. Yang, Tomoyuki Nakamura, Yukio Uchihori, Toru Nakamura, Koichi Sekino, Jon Paul Lundquist, Kenichi Kadota, Youngjoon Kwon, John Belz, Akimichi Taketa, Eiji Nishio, P. Tinyakov, Il Hung Park, Masato Takita, Ryota Fukushima, Ryota Onogi, J. H. Kim, Mikhail Kuznetsov, Maxim Pshirkov, Y. Takahashi, Mai Takamura, Yuto Arai, Isaac Myers, Hideyuki Kawai, Yuma Shibasaki, R. Mayta, Douglas Bergman, Grigory Rubtsov, Ryosuke Tsuda, Soomin Jeong, R. Sahara, T. Seki, Naoya Inoue, Yasunori Saito, Hiroyuki Matsumiya, Takafumi Uehama, Eiji Kido, Kazuhiro Machida, Telescope Array, Shoichi Kishigami, Masaomi Ono, Norimichi Shibata, Y. Omura, Monica Allen, Bokkyun Shin, ByongGu Cheon, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Hideyuki Ohoka, Yusuke Kimura, Toshio Matsuyama, Manobu Tanaka, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Robert Cady, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, and Kohei Yada

Subjects
Physics, Air shower, Scintillation counter, Cosmic ray, Astrophysics, Variation (astronomy), Intensity (heat transfer)
Published
2021

29. Anisotropy search in the Ultra High Energy Cosmic Ray Spectrum in the Northern Hemisphere using latest data obtained with Telescope Array surface detector

Author

Grigory Rubtsov, John Matthews, Norimichi Shibata, Y. Omura, J. Yang, Fumiya Shibata, Shingo Kawana, M. Ohnishi, Taichi Inadomi, Matt Potts, William Hanlon, Monica Allen, Bokkyun Shin, Fugo Yoshida, Yuma Shibasaki, ByongGu Cheon, Ben Stokes, Douglas Bergman, Jyunsei Chiba, Dongsu Ryu, Toshihiro Fujii, Koki Sato, Yasunori Saito, M. Yamamoto, Hirokazu Iwakura, Y. Takagi, Ryuhei Arimura, Hideyuki Ohoka, Yuto Kubota, Federico R. Urban, Nobuyuki Sakurai, Kengo Sano, Mikhail Kuznetsov, Heungsu Shin, Ivan Kharuk, Yukio Uchihori, Keitaro Fujita, K. H. Lee, Jihee Kim, Yoshiki Tsunesada, Daisuke Ikeda, Hirotaka Ito, Sergey Troitsky, Yuto Arai, Ryota Onogi, J. H. Kim, Maxim Pshirkov, Takeshi Okuda, Y. Nakamura, Kohei Yada, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Hiroyuki Matsumiya, Igor Tkachev, R. Mayta, Hideki Tanaka, Naohiro Sone, Ryosuke Tsuda, Tiffany Wong, Taka Tomida, J. Remington, Masaki Fukushima, Takafumi Uehama, Aoi Iwasaki, Daiki Shinto, Hideaki Shimodaira, Hyoming Jeong, Shoichi Kishigami, Soomin Jeong, Shigeharu Udo, Eiji Kido, Hiroyuki Sagawa, Takashi Sako, Ryo Higuchi, Hisono Tokuno, H. Oda, Gordon Thomson, Tom Stroman, Priti Shah, Ryo Nakamura, Robert Cady, Kazuhiro Machida, Masahiro Takeda, Pierre Sokolsky, Naoaki Hayashida, Ken Honda, Tatsunobu Shibata, T. Seki, G. Furlich, Takaaki Ishii, R. Sahara, Fumio Kakimoto, Naoya Inoue, Akitoshi Oshima, Vladim Kuzmin, Ryuji Takeishi, Ryota Fukushima, Shigehiro Nagataki, Shunsuke Ozawa, K. Yamazaki, Masaomi Ono, Elliott Barcikowski, Toshiyuki Nonaka, Saori Kasami, Tareq Abu-Zayyad, Zach Zundel, Yana Zhezher, Kenta Yashiro, Dmitri Ivanov, D. C. Rodriguez, Ricardo Gonzalez, Samuel Blake, Sang Woo Kim, Kinya Hibino, Shoichi Ogio, Keijiro Mukai, HangBae Kim, Yusuke Kimura, Rasha Abbasi, Koichi Tanaka, Yuya Oku, Michiyuki Chikawa, Jon Paul Lundquist, Katsuaki Kasahara, Stanton Thomas, Katsumasa Kawata, Oleg Kalashev, Yuichiro Tameda, Tomoyuki Nakamura, Tsubasa Yoshioka, Arata Nakazawa, Masato Takita, Toru Nakamura, Telescope Array, Min Hyo Kim, Toshio Matsuyama, Kei Nakai, Ryota Fujiwara, Kenichi Kadota, Manobu Tanaka, Il Hung Park, Naoto Sakaki, S. Kawakami, Akimichi Taketa, Eiji Nishio, Hideyuki Kawai, Shinnosuke Kurisu, Jeremy Smith, Isaac Myers, Youngjoon Kwon, John Belz, Koichi Sekino, P. Tinyakov, Y. Takahashi, Mai Takamura, Yuta Tanoue, Motoki Hayashi, and Kozo Fujisue

Subjects
Surface (mathematics), Telescope, Physics, law, Detector, Northern Hemisphere, Astrophysics, Ultra-high-energy cosmic ray, Anisotropy, law.invention
Published
2021

30. The measurements of the cosmic ray energy spectrum and the depth of maximum shower development of Telescope Array Hybrid trigger events

Author

Katsuaki Kasahara, Shinnosuke Kurisu, Katsumasa Kawata, Shingo Kawana, William Hanlon, Tsubasa Yoshioka, R. Sahara, Hideaki Shimodaira, Hyoming Jeong, Ryo Higuchi, Norimichi Shibata, Monica Allen, Bokkyun Shin, Jeremy Smith, Y. Omura, Vladim Kuzmin, G. Furlich, Takaaki Ishii, Akimichi Taketa, Toshio Matsuyama, Eiji Nishio, ByongGu Cheon, K. Yamazaki, Tareq Abu-Zayyad, Toshiyuki Nonaka, Hideyuki Ohoka, D. C. Rodriguez, Fumiya Shibata, Hiroyuki Matsumiya, Fugo Yoshida, HangBae Kim, Hiroyuki Sagawa, Ricardo Gonzalez, Pierre Sokolsky, Tatsunobu Shibata, Hideyuki Kawai, Takafumi Uehama, Manobu Tanaka, Rasha Abbasi, Takeshi Okuda, Youngjoon Kwon, John Belz, Yuma Shibasaki, Shigehiro Nagataki, Matt Potts, Yana Zhezher, Mikhail Kuznetsov, Akitoshi Oshima, Igor Tkachev, Sang Woo Kim, Eiji Kido, Koichi Tanaka, K. H. Lee, Jihee Kim, Kazuhiro Machida, Isaac Myers, Naohiro Sone, Shunsuke Ozawa, Hideki Tanaka, Heungsu Shin, Douglas Bergman, Gordon Thomson, Ryo Nakamura, Jon Paul Lundquist, Tom Stroman, Robert Cady, Yuta Tanoue, Ben Stokes, H. Oda, Grigory Rubtsov, Tomoyuki Nakamura, Yasunori Saito, Yuto Arai, Motoki Hayashi, Ryota Fujiwara, Federico R. Urban, Nobuyuki Sakurai, Ryosuke Tsuda, Hirotaka Ito, Hisono Tokuno, Elliott Barcikowski, Charlie Jui, Soomin Jeong, Naoto Sakaki, Kozo Fujisue, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Yuya Oku, Oleg Kalashev, Dmitri Ivanov, Fumio Kakimoto, Arata Nakazawa, Kenta Yashiro, Kei Nakai, T. Seki, Naoya Inoue, Keijiro Mukai, Min Hyo Kim, Yusuke Kimura, S. Kawakami, Stanton Thomas, M. Ohnishi, Taichi Inadomi, Koki Sato, Sergey Troitsky, Kengo Sano, Aoi Iwasaki, Toshihiro Fujii, Michiyuki Chikawa, Toru Nakamura, Taka Tomida, J. Remington, Kenichi Kadota, Yuto Kubota, Il Hung Park, Saori Kasami, Y. Nakamura, Kohei Yada, Koichi Sekino, Naoaki Hayashida, P. Tinyakov, Ryuji Takeishi, Ryuhei Arimura, Yoshiki Tsunesada, Daisuke Ikeda, Tiffany Wong, Masaki Fukushima, Takashi Sako, Zach Zundel, John Matthews, J. Yang, Daiki Shinto, Priti Shah, Jyunsei Chiba, Dongsu Ryu, Masahiro Takeda, Ken Honda, Hirokazu Iwakura, Y. Takagi, Shigeharu Udo, Keitaro Fujita, Ryota Fukushima, Ivan Kharuk, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Kinya Hibino, Yuichiro Tameda, Masato Takita, Shoichi Kishigami, Y. Takahashi, Mai Takamura, Masaomi Ono, Telescope Array, Samuel Blake, Shoichi Ogio, and Maxim Pshirkov

Subjects
Telescope, Physics, Shower, law, Energy spectrum, Astronomy, Cosmic ray, law.invention
Published
2021

31. Cosmic ray energy spectrum in the 2nd knee region measured by the TALE-SD array

Author

Taka Tomida, J. Remington, G. Furlich, Takaaki Ishii, D. C. Rodriguez, Stanton Thomas, Hideki Tanaka, HangBae Kim, Fumiya Shibata, Naoaki Hayashida, Hiroyuki Matsumiya, ByongGu Cheon, Fugo Yoshida, Michiyuki Chikawa, Pierre Sokolsky, Shigehiro Nagataki, Yana Zhezher, Isaac Myers, Maxim Pshirkov, Sang Woo Kim, Matt Potts, Telescope Array, Hisono Tokuno, Ryuhei Arimura, Vladim Kuzmin, Daiki Shinto, Toru Nakamura, Takafumi Uehama, Koichi Sekino, Tomoyuki Nakamura, Takeshi Okuda, P. Tinyakov, Heungsu Shin, R. Sahara, Aoi Iwasaki, Yoshiki Tsunesada, Kenichi Kadota, Priti Shah, Daisuke Ikeda, Igor Tkachev, Il Hung Park, Toshiyuki Nonaka, Hideyuki Ohoka, Shoichi Kishigami, Rasha Abbasi, Masahiro Takeda, Naohiro Sone, Arata Nakazawa, Y. Takahashi, Mai Takamura, Ricardo Gonzalez, Tiffany Wong, Eiji Kido, Kei Nakai, Ben Stokes, Kazuhiro Machida, Masaki Fukushima, Ken Honda, H. Oda, Katsuaki Kasahara, Masaomi Ono, Yuto Arai, Toshihiro Fujii, Jyunsei Chiba, Katsumasa Kawata, Takashi Sako, Charlie Jui, Yuta Tanoue, Dongsu Ryu, Federico R. Urban, Nobuyuki Sakurai, Motoki Hayashi, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Kenta Yashiro, Yuto Kubota, Saori Kasami, Kozo Fujisue, Tsubasa Yoshioka, John Matthews, Hirokazu Iwakura, Shingo Kawana, Y. Takagi, Ryosuke Tsuda, Soomin Jeong, Yasunori Saito, Zach Zundel, J. Yang, William Hanlon, Fumio Kakimoto, Grigory Rubtsov, Ryuji Takeishi, Tatsunobu Shibata, Samuel Blake, Shoichi Ogio, T. Seki, Akitoshi Oshima, Yuya Oku, M. Ohnishi, Ryota Fujiwara, Taichi Inadomi, Y. Nakamura, Oleg Kalashev, Kohei Yada, Keitaro Fujita, Shunsuke Ozawa, Koki Sato, Yuichiro Tameda, Monica Allen, Bokkyun Shin, Naoto Sakaki, Naoya Inoue, Kengo Sano, Ryota Fukushima, Hirotaka Ito, Youngjoon Kwon, Ivan Kharuk, Masato Takita, John Belz, Norimichi Shibata, Y. Omura, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Hideaki Shimodaira, Hyoming Jeong, Kinya Hibino, Ryo Higuchi, Toshio Matsuyama, K. Yamazaki, Tareq Abu-Zayyad, Manobu Tanaka, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Akimichi Taketa, Robert Cady, Mikhail Kuznetsov, Eiji Nishio, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Shigeharu Udo, Hideyuki Kawai, Shinnosuke Kurisu, Ryo Nakamura, Jeremy Smith, Yuma Shibasaki, Min Hyo Kim, Douglas Bergman, S. Kawakami, Hiroyuki Sagawa, Koichi Tanaka, Jon Paul Lundquist, and Sergey Troitsky

Subjects
Physics, Energy spectrum, Cosmic ray, Knee region, Astrophysics
Published
2021

32. Cosmic Ray Composition between 2 PeV and 2 EeV measured by the TALE Fluorescence Detector

Author

Shigeharu Udo, Daiki Shinto, Fumiya Shibata, Priti Shah, Stanton Thomas, Norimichi Shibata, Y. Omura, Matt Potts, Masahiro Takeda, Ken Honda, Ryo Nakamura, Youngjoon Kwon, Vladim Kuzmin, John Belz, Telescope Array, Yasunori Saito, Shinnosuke Kurisu, Yuta Tanoue, Motoki Hayashi, Tatsunobu Shibata, ByongGu Cheon, Saori Kasami, M. Yamamoto, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Fumio Kakimoto, John N. Matthews, K. H. Lee, Jihee Kim, Tomoyuki Nakamura, Yukio Uchihori, J. P. Lundquist, Akitoshi Oshima, Hideyuki Ohoka, Michiyuki Chikawa, Toru Nakamura, Fugo Yoshida, Ryota Onogi, J. H. Kim, Keitaro Fujita, Kozo Fujisue, Hideki Tanaka, Shunsuke Ozawa, Jeremy Smith, Kenichi Kadota, Il Hung Park, H. Oda, Takashi Sako, Charlie Jui, Hiroyuki Matsumiya, R. Mayta, Shoichi Kishigami, Akimichi Taketa, Gordon Thomson, Hisono Tokuno, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Takafumi Uehama, Ryota Fujiwara, Eiji Nishio, Sergey Troitsky, Kinya Hibino, Min Hyo Kim, Masaomi Ono, Maxim Pshirkov, Tom Stroman, Robert Cady, Pierre Sokolsky, Taka Tomida, Shingo Kawana, Eiji Kido, Kazuhiro Machida, J. Remington, Naoto Sakaki, Katsuaki Kasahara, Shigehiro Nagataki, Yana Zhezher, M. Ohnishi, Taichi Inadomi, Yuto Kubota, Zach Zundel, Ben Stokes, William Hanlon, Sang Woo Kim, Koki Sato, Federico R. Urban, Nobuyuki Sakurai, Hideyuki Kawai, Yuma Shibasaki, Ryuhei Arimura, Katsumasa Kawata, J. Yang, Koichi Sekino, Monica Allen, Bokkyun Shin, Naoaki Hayashida, Kengo Sano, P. Tinyakov, Yoshiki Tsunesada, Daisuke Ikeda, Y. Nakamura, Douglas Bergman, Kohei Yada, S. Kawakami, Kenta Yashiro, Y. Takahashi, Mai Takamura, Tiffany Wong, Heungsu Shin, Tsubasa Yoshioka, Masaki Fukushima, Yuya Oku, Oleg Kalashev, Hiroyuki Sagawa, Samuel Blake, Shoichi Ogio, Toshiyuki Nonaka, Ricardo Gonzalez, Yuichiro Tameda, Yuto Arai, Koichi Tanaka, Rasha Abbasi, T. Fujii, Masato Takita, Toshio Matsuyama, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Manobu Tanaka, Yusuke Kimura, Ryosuke Tsuda, Soomin Jeong, T. Seki, Naoya Inoue, Arata Nakazawa, Kei Nakai, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Isaac Myers, Hideaki Shimodaira, Hyoming Jeong, Ryo Higuchi, K. Yamazaki, Tareq Abu-Zayyad, Mikhail Kuznetsov, Grigory Rubtsov, Hirotaka Ito, Aoi Iwasaki, Ivan Kharuk, Ryuji Takeishi, R. Sahara, Ryota Fukushima, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, and Y. Takagi

Subjects
Physics, Cosmic ray, Astrophysics, Fluorescence spectroscopy
Published
2021

33. The status of the TALE surface detector array and TALE infill project

Author

Takashi Sako, Zach Zundel, Shigeharu Udo, Kenta Yashiro, Toru Nakamura, Kenichi Kadota, Il Hung Park, Min Hyo Kim, Ryo Nakamura, Tatsunobu Shibata, R. Sahara, Noemie Globus, Elliott Barcikowski, S. Kawakami, Akitoshi Oshima, Dmitri Ivanov, Grigory Rubtsov, Fugo Yoshida, Shunsuke Ozawa, Keijiro Mukai, Charlie Jui, BayarJon Paul Lubsandorzhiev, Yusuke Kimura, Fumio Kakimoto, Mayuko Minamino, Saori Kasami, G. Furlich, Takaaki Ishii, Norimichi Shibata, Fumiya Shibata, Hiroyuki Sagawa, Y. Omura, D. C. Rodriguez, Matt Potts, Aoi Iwasaki, HangBae Kim, Koichi Tanaka, Jon Paul Lundquist, Ryota Fukushima, Monica Allen, Bokkyun Shin, Yuya Oku, Ryuji Takeishi, Vladim Kuzmin, Oleg Kalashev, Telescope Array, M. Yamamoto, Youngjoon Kwon, Arata Nakazawa, John Belz, Kei Nakai, Yukio Uchihori, Stanton Thomas, Yasunori Saito, Maxim Pshirkov, Michiyuki Chikawa, Ben Stokes, Ryota Onogi, J. H. Kim, Hirotaka Ito, R. Mayta, Ryuhei Arimura, Shoichi Kishigami, Pierre Sokolsky, Federico R. Urban, Nobuyuki Sakurai, Hideki Tanaka, Kinya Hibino, Yoshiki Tsunesada, Shigehiro Nagataki, Yana Zhezher, Masaomi Ono, Sang Woo Kim, Sergey Troitsky, Hisono Tokuno, Taka Tomida, J. Remington, Rasha Abbasi, M. Ohnishi, Taichi Inadomi, Naoaki Hayashida, Hideaki Shimodaira, Hyoming Jeong, Isaac Myers, Koki Sato, Ryo Higuchi, Toshihiro Fujii, Tomoyuki Nakamura, Hiroyuki Matsumiya, Ryota Fujiwara, Takafumi Uehama, ByongGu Cheon, Yuto Kubota, Eiji Kido, Naoto Sakaki, Kazuhiro Machida, Kengo Sano, Katsuaki Kasahara, K. Yamazaki, Katsumasa Kawata, Tareq Abu-Zayyad, Tsubasa Yoshioka, Takeshi Okuda, Igor Tkachev, Y. Nakamura, Kohei Yada, Naohiro Sone, Mikhail Kuznetsov, Hideyuki Ohoka, H. Oda, Akimichi Taketa, Eiji Nishio, Ivan Kharuk, Hideyuki Kawai, Yuma Shibasaki, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, Y. Takagi, Douglas Bergman, Shinnosuke Kurisu, Jeremy Smith, Toshio Matsuyama, K. H. Lee, Jihee Kim, Gordon Thomson, Tom Stroman, Robert Cady, Manobu Tanaka, Keitaro Fujita, Daiki Shinto, Priti Shah, Masahiro Takeda, Ken Honda, John Matthews, J. Yang, Koichi Sekino, P. Tinyakov, Y. Takahashi, Mai Takamura, Daisuke Ikeda, Tiffany Wong, Masaki Fukushima, Yuta Tanoue, Motoki Hayashi, Heungsu Shin, Kozo Fujisue, Yuto Arai, Ryosuke Tsuda, Soomin Jeong, Shingo Kawana, William Hanlon, T. Seki, Toshiyuki Nonaka, Ricardo Gonzalez, Naoya Inoue, Yuichiro Tameda, Masato Takita, Samuel Blake, and Shoichi Ogio

Subjects
Surface (mathematics), Optics, business.industry, Infill, Detector array, business, Geology
Published
2021

34. Current status and prospects of surface detector of the TAx4 experiment

Author

Katsumasa Kawata, Grigory Rubtsov, Tsubasa Yoshioka, Tatsunobu Shibata, Yuichiro Tameda, Kenta Yashiro, Akitoshi Oshima, Fugo Yoshida, Jyunsei Chiba, Ryosuke Tsuda, Soomin Jeong, M. Yamamoto, Ryo Nakamura, Shunsuke Ozawa, Dongsu Ryu, Takashi Sako, Shingo Kawana, Hirokazu Iwakura, Y. Takagi, ByongGu Cheon, T. Seki, Naoya Inoue, Yukio Uchihori, Hideaki Shimodaira, Hyoming Jeong, Hideki Tanaka, Aoi Iwasaki, John Matthews, Ryota Onogi, J. H. Kim, William Hanlon, Ryo Higuchi, Fumiya Shibata, J. Yang, Hisono Tokuno, Masato Takita, Akimichi Taketa, M. Ohnishi, Taichi Inadomi, Hideyuki Ohoka, Ryota Fujiwara, Youngjoon Kwon, John Belz, R. Mayta, Yuta Tanoue, Koki Sato, Eiji Nishio, Motoki Hayashi, Naoto Sakaki, Ryota Fukushima, Matt Potts, Ivan Kharuk, K. Yamazaki, Ben Stokes, Sergey Troitsky, Min Hyo Kim, Tareq Abu-Zayyad, Kengo Sano, Kozo Fujisue, Zach Zundel, Kinya Hibino, Saori Kasami, Toru Nakamura, R. Sahara, Taka Tomida, J. Remington, Federico R. Urban, Nobuyuki Sakurai, Takeshi Okuda, Igor Tkachev, Naohiro Sone, Samuel Blake, Shoichi Ogio, Kenichi Kadota, Il Hung Park, Hideyuki Kawai, Rasha Abbasi, Keitaro Fujita, Koichi Sekino, H. Oda, Mikhail Kuznetsov, Heungsu Shin, Shinnosuke Kurisu, Toshiyuki Nonaka, Ricardo Gonzalez, P. Tinyakov, S. Kawakami, Charlie Jui, Fumio Kakimoto, Yuto Arai, Naoaki Hayashida, Shigeharu Udo, Yuya Oku, Michiyuki Chikawa, Oleg Kalashev, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Y. Takahashi, Mai Takamura, Jeremy Smith, Ryuhei Arimura, Daiki Shinto, Monica Allen, Bokkyun Shin, Yuma Shibasaki, Priti Shah, Hiroyuki Sagawa, Masahiro Takeda, Vladim Kuzmin, Yoshiki Tsunesada, Daisuke Ikeda, Ken Honda, Toshio Matsuyama, Douglas Bergman, Tiffany Wong, Koichi Tanaka, Masaki Fukushima, Jon Paul Lundquist, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Manobu Tanaka, K. H. Lee, Jihee Kim, Maxim Pshirkov, Gordon Thomson, Toshihiro Fujii, Tom Stroman, Robert Cady, Yuto Kubota, Y. Nakamura, Kohei Yada, Pierre Sokolsky, Shigehiro Nagataki, Shoichi Kishigami, Yana Zhezher, Sang Woo Kim, Masaomi Ono, Telescope Array, Tomoyuki Nakamura, Stanton Thomas, Hiroyuki Matsumiya, Takafumi Uehama, Eiji Kido, Kazuhiro Machida, Yasunori Saito, Isaac Myers, Norimichi Shibata, Y. Omura, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Arata Nakazawa, Kei Nakai, Hirotaka Ito, Ryuji Takeishi, and Katsuaki Kasahara

Subjects
Physics, Surface (mathematics), Optics, business.industry, Detector, Current (fluid), business
Published
2021

35. Cosmic Ray Composition in the Second Knee Region as Measured by the TALE Hybrid Detector

Author

ByongGu Cheon, Hiroyuki Matsumiya, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Takashi Sako, Ivan Kharuk, Takeshi Okuda, Igor Tkachev, Takafumi Uehama, Hideyuki Ohoka, Daiki Shinto, Priti Shah, Isaac Myers, K. H. Lee, Jihee Kim, Telescope Array, Naohiro Sone, Eiji Kido, Fugo Yoshida, Kazuhiro Machida, Aoi Iwasaki, Hideaki Shimodaira, Hyoming Jeong, Masahiro Takeda, Ken Honda, H. Oda, Zach Zundel, Yuta Tanoue, Fumiya Shibata, Gordon Thomson, Tom Stroman, Robert Cady, Shoichi Kishigami, Ryo Higuchi, Youngjoon Kwon, Sergey Troitsky, Motoki Hayashi, Masaomi Ono, John Belz, Kozo Fujisue, Stanton Thomas, Kinya Hibino, Elliott Barcikowski, Matt Potts, Taka Tomida, Dmitri Ivanov, John Matthews, Samuel Blake, Ryuhei Arimura, J. Remington, M. Ohnishi, Taichi Inadomi, Koichi Sekino, Shoichi Ogio, Keijiro Mukai, J. Yang, P. Tinyakov, K. Yamazaki, G. Furlich, Takaaki Ishii, Pierre Sokolsky, Norimichi Shibata, Yuichiro Tameda, Shingo Kawana, Yusuke Kimura, Y. Omura, Tareq Abu-Zayyad, Yoshiki Tsunesada, Ryuji Takeishi, Daisuke Ikeda, Y. Takahashi, Mai Takamura, Koki Sato, Shigehiro Nagataki, Yana Zhezher, Jyunsei Chiba, Dongsu Ryu, William Hanlon, Hiroyuki Sagawa, Shigeharu Udo, Sang Woo Kim, D. C. Rodriguez, Kengo Sano, Tatsunobu Shibata, Tiffany Wong, Hirokazu Iwakura, Y. Takagi, HangBae Kim, Toshihiro Fujii, Mikhail Kuznetsov, Masato Takita, Keitaro Fujita, Yasunori Saito, Masaki Fukushima, Akitoshi Oshima, Yuto Kubota, Vladim Kuzmin, Kenta Yashiro, Grigory Rubtsov, Shunsuke Ozawa, Tomoyuki Nakamura, Manobu Tanaka, Y. Nakamura, Kohei Yada, Koichi Tanaka, Ryosuke Tsuda, Fumio Kakimoto, Ben Stokes, Ryota Fukushima, Naoaki Hayashida, M. Yamamoto, Monica Allen, Bokkyun Shin, Soomin Jeong, Michiyuki Chikawa, R. Sahara, Jon Paul Lundquist, Federico R. Urban, Arata Nakazawa, Nobuyuki Sakurai, Toshiyuki Nonaka, Yukio Uchihori, Kei Nakai, Ryota Onogi, J. H. Kim, Ricardo Gonzalez, Maxim Pshirkov, Toshio Matsuyama, T. Seki, Naoya Inoue, R. Mayta, Hirotaka Ito, Min Hyo Kim, S. Kawakami, Heungsu Shin, Yuto Arai, Saori Kasami, Ryo Nakamura, Hideki Tanaka, Hisono Tokuno, Yuma Shibasaki, Douglas Bergman, Akimichi Taketa, Eiji Nishio, Yuya Oku, Hideyuki Kawai, Shinnosuke Kurisu, Oleg Kalashev, Jeremy Smith, Toru Nakamura, Kenichi Kadota, Il Hung Park, Ryota Fujiwara, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Tsubasa Yoshioka, and Rasha Abbasi

Subjects
Physics, Detector, Cosmic ray, Knee region, Astrophysics, Composition (combinatorics)
Published
2021

36. Effects of Galactic magnetic field on the UHECR anisotropy studies

Author

Tomoyuki Nakamura, Sergey Troitsky, Taka Tomida, M. Yamamoto, Fugo Yoshida, J. Remington, M. Ohnishi, Taichi Inadomi, Elliott Barcikowski, Stanton Thomas, Pierre Sokolsky, Yuichiro Tameda, Hideaki Shimodaira, Hyoming Jeong, Dmitri Ivanov, R. Sahara, Shigehiro Nagataki, Yana Zhezher, Ryota Fujiwara, Sang Woo Kim, Yukio Uchihori, Manobu Tanaka, Ryo Higuchi, Ivan Kharuk, Keijiro Mukai, Koki Sato, ByongGu Cheon, Norimichi Shibata, Yuma Shibasaki, Ryota Onogi, J. H. Kim, Y. Omura, Keitaro Fujita, Naoto Sakaki, Aoi Iwasaki, Yusuke Kimura, K. H. Lee, Jihee Kim, Hideyuki Ohoka, R. Mayta, Kengo Sano, Gordon Thomson, K. Yamazaki, Tom Stroman, Robert Cady, Tareq Abu-Zayyad, Kinya Hibino, Toru Nakamura, Yasunori Saito, Douglas Bergman, Naoaki Hayashida, Takeshi Okuda, Igor Tkachev, Mikhail Kuznetsov, Min Hyo Kim, Kenichi Kadota, Michiyuki Chikawa, Rasha Abbasi, Ryosuke Tsuda, Yuta Tanoue, Naohiro Sone, Il Hung Park, Masato Takita, Soomin Jeong, John N. Matthews, Katsuaki Kasahara, H. Oda, Saori Kasami, Shinnosuke Kurisu, Motoki Hayashi, Takashi Sako, Katsumasa Kawata, Youngjoon Kwon, John Belz, Ben Stokes, J. P. Lundquist, Arata Nakazawa, S. Kawakami, Monica Allen, Bokkyun Shin, T. Seki, Yuto Kubota, Kozo Fujisue, Federico R. Urban, Hiroyuki Matsumiya, Nobuyuki Sakurai, Tsubasa Yoshioka, Naoya Inoue, Vladim Kuzmin, J. Yang, Shigeharu Udo, Kei Nakai, Kenta Yashiro, T. Fujii, Hiroyuki Sagawa, Maxim Pshirkov, Takafumi Uehama, Shingo Kawana, Kazumasa Kawata, Toshio Matsuyama, Y. Nakamura, Jeremy Smith, Yuya Oku, Kohei Yada, Koichi Tanaka, Akimichi Taketa, Koichi Sekino, Hideki Tanaka, Oleg Kalashev, Eiji Kido, Tatsunobu Shibata, William Hanlon, Daiki Shinto, Eiji Nishio, Kazuhiro Machida, Jyunsei Chiba, Dongsu Ryu, Telescope Array, Zach Zundel, Akitoshi Oshima, Priti Shah, P. Tinyakov, Heungsu Shin, Fumio Kakimoto, Shunsuke Ozawa, Isaac Myers, Ryuhei Arimura, Hisono Tokuno, Masahiro Takeda, Ken Honda, Ryuji Takeishi, Yoshiki Tsunesada, Daisuke Ikeda, Hideyuki Kawai, Hirokazu Iwakura, Y. Takagi, Tiffany Wong, Samuel Blake, Masaki Fukushima, Shoichi Ogio, Yuto Arai, Toshiyuki Nonaka, Shoichi Kishigami, Ricardo Gonzalez, G. Furlich, Takaaki Ishii, Y. Takahashi, Mai Takamura, Masaomi Ono, D. C. Rodriguez, HangBae Kim, Grigory Rubtsov, Ryota Fukushima, Hirotaka Ito, Ryo Nakamura, Charlie Jui, BayarJon Paul Lubsandorzhiev, Mayuko Minamino, Fumiya Shibata, and Matt Potts

Subjects
Physics, Astrophysics, Anisotropy, Magnetic field
Published
2021

37. Mass composition of Telescope Array's surface detectors events using deep learning

Author

Hideaki Shimodaira, Hyoming Jeong, Hiroyuki Sagawa, Fumiya Shibata, Ryuji Takeishi, Ryo Higuchi, Youngjoon Kwon, John Belz, Hideyuki Ohoka, Ryo Nakamura, Rasha Abbasi, Daiki Shinto, Ryuhei Arimura, Koichi Tanaka, Yoshiki Tsunesada, Daisuke Ikeda, Michiyuki Chikawa, Tiffany Wong, Masaki Fukushima, Matt Potts, Yuma Shibasaki, Priti Shah, Jon Paul Lundquist, K. Yamazaki, Pierre Sokolsky, Katsuaki Kasahara, Katsumasa Kawata, Tareq Abu-Zayyad, Fugo Yoshida, Masahiro Takeda, Takashi Sako, Ken Honda, Zach Zundel, Shigehiro Nagataki, Yana Zhezher, Ben Stokes, Tsubasa Yoshioka, Kenta Yashiro, Sergey Troitsky, R. Sahara, Douglas Bergman, Sang Woo Kim, Taka Tomida, Shingo Kawana, Charlie Jui, BayarJon Paul Lubsandorzhiev, J. Remington, Mayuko Minamino, Mikhail Kuznetsov, Min Hyo Kim, Shinnosuke Kurisu, William Hanlon, Ryota Fujiwara, Elliott Barcikowski, Dmitri Ivanov, Monica Allen, Naoto Sakaki, Tomoyuki Nakamura, G. Furlich, Takaaki Ishii, Federico R. Urban, Nobuyuki Sakurai, Saori Kasami, Keijiro Mukai, Bokkyun Shin, Toshio Matsuyama, K. H. Lee, Jihee Kim, Gordon Thomson, Ryota Fukushima, Samuel Blake, Shoichi Ogio, Hirotaka Ito, Yusuke Kimura, Tom Stroman, Robert Cady, Naoaki Hayashida, Norimichi Shibata, Y. Omura, S. Kawakami, D. C. Rodriguez, Keitaro Fujita, Jeremy Smith, HangBae Kim, Takeshi Okuda, Igor Tkachev, Akimichi Taketa, Hideki Tanaka, Stanton Thomas, Naohiro Sone, Isaac Myers, Eiji Nishio, Yuya Oku, Aoi Iwasaki, Oleg Kalashev, Hiroyuki Matsumiya, Toshihiro Fujii, Hisono Tokuno, H. Oda, Jyunsei Chiba, Grigory Rubtsov, Dongsu Ryu, Manobu Tanaka, Yuto Kubota, Koichi Sekino, Takafumi Uehama, Maxim Pshirkov, Hideyuki Kawai, P. Tinyakov, Toru Nakamura, Kenichi Kadota, M. Ohnishi, Y. Nakamura, Il Hung Park, Kohei Yada, Hirokazu Iwakura, Taichi Inadomi, Y. Takagi, Y. Takahashi, Mai Takamura, Eiji Kido, Kazuhiro Machida, Arata Nakazawa, Koki Sato, John Matthews, Toshiyuki Nonaka, Kei Nakai, Ivan Kharuk, J. Yang, Ricardo Gonzalez, Kengo Sano, Yasunori Saito, Yuta Tanoue, Fumio Kakimoto, Motoki Hayashi, Yuichiro Tameda, Kozo Fujisue, Shoichi Kishigami, Masaomi Ono, Masato Takita, Telescope Array, Shigeharu Udo, Kinya Hibino, M. Yamamoto, Yukio Uchihori, Ryota Onogi, J. H. Kim, R. Mayta, Vladim Kuzmin, Ryosuke Tsuda, Soomin Jeong, T. Seki, Naoya Inoue, Heungsu Shin, Yuto Arai, Tatsunobu Shibata, Akitoshi Oshima, Shunsuke Ozawa, and ByongGu Cheon

Subjects
Surface (mathematics), Telescope, Physics, Optics, business.industry, law, Deep learning, Detector, Artificial intelligence, Mass composition, business, law.invention
Published
2021

38. FOV direction and image size calibration of Fluorescence Detector using light source on UAV

Author

Telescope Array, Yasunori Saito, Shoichi Kishigami, Hideaki Shimodaira, Hyoming Jeong, Masaomi Ono, Ryo Higuchi, Ryuhei Arimura, Fugo Yoshida, Ryo Nakamura, Tomoyuki Nakamura, Charlie Jui, Min Hyo Kim, M. Ohnishi, Taichi Inadomi, Hideki Tanaka, Hisono Tokuno, BayarJon Paul Lubsandorzhiev, John Matthews, Yoshiki Tsunesada, Heungsu Shin, Manobu Tanaka, Koki Sato, Mayuko Minamino, J. Yang, Daisuke Ikeda, K. Yamazaki, Tareq Abu-Zayyad, M. Yamamoto, S. Kawakami, Kengo Sano, Sergey Troitsky, Fumio Kakimoto, Yuto Arai, Tiffany Wong, Taka Tomida, J. Remington, Koichi Sekino, Stanton Thomas, Kenta Yashiro, Ryosuke Tsuda, Saori Kasami, Monica Allen, Yukio Uchihori, Masaki Fukushima, Fumiya Shibata, Ben Stokes, Toshio Matsuyama, P. Tinyakov, Mikhail Kuznetsov, Soomin Jeong, Bokkyun Shin, Pierre Sokolsky, Norimichi Shibata, Hiroyuki Sagawa, K. H. Lee, Jihee Kim, Y. Omura, Ryota Onogi, J. H. Kim, Gordon Thomson, G. Furlich, Takaaki Ishii, Tom Stroman, Robert Cady, Y. Takahashi, Mai Takamura, ByongGu Cheon, Matt Potts, Shigehiro Nagataki, Yana Zhezher, Keitaro Fujita, Federico R. Urban, Nobuyuki Sakurai, Koichi Tanaka, Naoaki Hayashida, T. Seki, Naoya Inoue, R. Mayta, Jon Paul Lundquist, Sang Woo Kim, Hiroyuki Matsumiya, Yuta Tanoue, Yuichiro Tameda, Kinya Hibino, Motoki Hayashi, Takafumi Uehama, D. C. Rodriguez, Eiji Kido, Maxim Pshirkov, Kozo Fujisue, Takeshi Okuda, Kazuhiro Machida, HangBae Kim, Hideyuki Ohoka, Igor Tkachev, Naohiro Sone, Shigeharu Udo, Shinnosuke Kurisu, Grigory Rubtsov, Tatsunobu Shibata, H. Oda, Michiyuki Chikawa, Daiki Shinto, Arata Nakazawa, Kei Nakai, Akitoshi Oshima, Priti Shah, R. Sahara, Jeremy Smith, Akimichi Taketa, Eiji Nishio, Masahiro Takeda, Takashi Sako, Vladim Kuzmin, Ken Honda, Masato Takita, Shunsuke Ozawa, Isaac Myers, Hideyuki Kawai, Yuma Shibasaki, Douglas Bergman, Samuel Blake, Shoichi Ogio, Zach Zundel, Jyunsei Chiba, Dongsu Ryu, Hirokazu Iwakura, Y. Takagi, Ivan Kharuk, Toru Nakamura, Elliott Barcikowski, Kenichi Kadota, Dmitri Ivanov, Il Hung Park, Keijiro Mukai, Yusuke Kimura, Yuya Oku, Oleg Kalashev, Ryota Fukushima, Youngjoon Kwon, John Belz, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, Kohei Yada, Hirotaka Ito, Rasha Abbasi, Aoi Iwasaki, Ryota Fujiwara, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Tsubasa Yoshioka, Ryuji Takeishi, Shingo Kawana, William Hanlon, Toshiyuki Nonaka, and Ricardo Gonzalez

Subjects
Physics, Light source, Optics, business.industry, Calibration, business, Image resolution, Fluorescence spectroscopy
Published
2021

39. UHECR mass composition from anisotropy of their arrival directions with the Telescope Array SD

Author

Katsuaki Kasahara, Ryota Fukushima, Takeshi Okuda, Igor Tkachev, Katsumasa Kawata, Daiki Shinto, Naohiro Sone, ByongGu Cheon, Shoichi Kishigami, Norimichi Shibata, Manobu Tanaka, Grigory Rubtsov, Ryuhei Arimura, M. Yamamoto, H. Oda, Masaomi Ono, Priti Shah, Y. Omura, Yoshiki Tsunesada, Tsubasa Yoshioka, Daisuke Ikeda, Masahiro Takeda, Tiffany Wong, Mikhail Kuznetsov, Ken Honda, K. H. Lee, Jihee Kim, Kenta Yashiro, Gordon Thomson, Hideyuki Ohoka, Yuichiro Tameda, Yukio Uchihori, Masaki Fukushima, Hiroyuki Sagawa, R. Sahara, Charlie Jui, Jyunsei Chiba, Dongsu Ryu, Tom Stroman, Fugo Yoshida, Robert Cady, Ryota Onogi, J. H. Kim, Shinnosuke Kurisu, Shingo Kawana, Ryota Fujiwara, BayarJon Paul Lubsandorzhiev, William Hanlon, Hirokazu Iwakura, Y. Takagi, R. Mayta, Hiroyuki Matsumiya, Koichi Tanaka, Mayuko Minamino, Vladim Kuzmin, Hideaki Shimodaira, Ivan Kharuk, Jon Paul Lundquist, Naoto Sakaki, Youngjoon Kwon, Kinya Hibino, John Belz, Ryo Nakamura, Hyoming Jeong, Michiyuki Chikawa, Keitaro Fujita, Takafumi Uehama, Saori Kasami, Fumiya Shibata, Ryo Higuchi, Yuya Oku, M. Ohnishi, Takashi Sako, Masato Takita, Eiji Kido, Toshiyuki Nonaka, Taichi Inadomi, Oleg Kalashev, Ryosuke Tsuda, Soomin Jeong, Ricardo Gonzalez, Rasha Abbasi, Kazuhiro Machida, Toshio Matsuyama, Min Hyo Kim, Matt Potts, Koki Sato, Kengo Sano, K. Yamazaki, Tareq Abu-Zayyad, Hideki Tanaka, Zach Zundel, S. Kawakami, Yasunori Saito, Peter Tinyakov, Samuel Blake, Shoichi Ogio, Shigeharu Udo, T. Seki, Toru Nakamura, Naoya Inoue, Jeremy Smith, John Matthews, J. Yang, Monica Allen, Kenichi Kadota, Hisono Tokuno, Yuta Tanoue, Akimichi Taketa, Bokkyun Shin, Eiji Nishio, Il Hung Park, Motoki Hayashi, Ben Stokes, Kozo Fujisue, Heungsu Shin, Federico R. Urban, Nobuyuki Sakurai, Hideyuki Kawai, Yuma Shibasaki, Koichi Sekino, Yuto Arai, Douglas Bergman, Tatsunobu Shibata, Y. Takahashi, Mai Takamura, Akitoshi Oshima, Shunsuke Ozawa, Maxim Pshirkov, Fumio Kakimoto, Sergey Troitsky, Taka Tomida, J. Remington, Naoaki Hayashida, Toshihiro Fujii, Yuto Kubota, Y. Nakamura, Kohei Yada, Elliott Barcikowski, Dmitri Ivanov, Keijiro Mukai, Yusuke Kimura, Stanton Thomas, Aoi Iwasaki, Tomoyuki Nakamura, Ryuji Takeishi, Pierre Sokolsky, Shigehiro Nagataki, Yana Zhezher, Isaac Myers, Sang Woo Kim, Hirotaka Ito, G. Furlich, Takaaki Ishii, D. C. Rodriguez, HangBae Kim, Arata Nakazawa, and Kei Nakai

Subjects
Telescope, Physics, law, Astrophysics, Mass composition, Anisotropy, law.invention
Published
2021

40. Analysis of TAx4 hybrid trigger and events

Author

Ivan Kharuk, Yuma Shibasaki, Jyunsei Chiba, Dongsu Ryu, Aoi Iwasaki, Hirokazu Iwakura, Y. Takagi, K. H. Lee, Jihee Kim, Ryota Fukushima, Ryuhei Arimura, Shigeharu Udo, Fumiya Shibata, Gordon Thomson, Hideki Tanaka, Fugo Yoshida, Tom Stroman, Robert Cady, Yoshiki Tsunesada, Sergey Troitsky, Daisuke Ikeda, Douglas Bergman, Taka Tomida, J. Remington, Tiffany Wong, John Matthews, ByongGu Cheon, Hiroyuki Matsumiya, Ryo Nakamura, Ryuji Takeishi, Masaki Fukushima, Hisono Tokuno, Ryosuke Tsuda, Soomin Jeong, M. Yamamoto, J. Yang, Matt Potts, Pierre Sokolsky, Min Hyo Kim, Yukio Uchihori, Naoaki Hayashida, Takashi Sako, T. Seki, Shigehiro Nagataki, Yana Zhezher, Akimichi Taketa, Naoya Inoue, Tatsunobu Shibata, Daiki Shinto, Sang Woo Kim, Eiji Nishio, Ryota Onogi, J. H. Kim, Priti Shah, Takafumi Uehama, G. Furlich, Takaaki Ishii, Saori Kasami, Hideaki Shimodaira, Hyoming Jeong, Masahiro Takeda, Charlie Jui, Ken Honda, R. Mayta, S. Kawakami, Heungsu Shin, BayarJon Paul Lubsandorzhiev, Ryo Higuchi, Toru Nakamura, Yuta Tanoue, Mayuko Minamino, Kenichi Kadota, Zach Zundel, Akitoshi Oshima, Eiji Kido, Elliott Barcikowski, Shingo Kawana, Shoichi Kishigami, Yuto Arai, Keitaro Fujita, Motoki Hayashi, Yuichiro Tameda, Hideyuki Ohoka, Il Hung Park, Kinya Hibino, Hirotaka Ito, Toshio Matsuyama, Kazuhiro Machida, Hiroyuki Sagawa, Hideyuki Kawai, D. C. Rodriguez, Dmitri Ivanov, Vladim Kuzmin, William Hanlon, Stanton Thomas, HangBae Kim, Shinnosuke Kurisu, Kozo Fujisue, Keijiro Mukai, K. Yamazaki, Masaomi Ono, Michiyuki Chikawa, Tareq Abu-Zayyad, Yusuke Kimura, Yasunori Saito, Koichi Tanaka, Grigory Rubtsov, Tomoyuki Nakamura, Jon Paul Lundquist, Koichi Sekino, Shunsuke Ozawa, Yuya Oku, P. Tinyakov, Isaac Myers, Oleg Kalashev, Masato Takita, Y. Takahashi, Mai Takamura, R. Sahara, Telescope Array, S. W. Kim, Manobu Tanaka, Toshiyuki Nonaka, Jeremy Smith, Norimichi Shibata, Y. Omura, Mikhail Kuznetsov, Ricardo Gonzalez, Ben Stokes, Samuel Blake, Toshihiro Fujii, Monica Allen, Shoichi Ogio, Yuto Kubota, Bokkyun Shin, Y. Nakamura, Kohei Yada, Federico R. Urban, Arata Nakazawa, Nobuyuki Sakurai, Kei Nakai, Youngjoon Kwon, John Belz, Rasha Abbasi, M. Ohnishi, Taichi Inadomi, Koki Sato, Fumio Kakimoto, Ryota Fujiwara, Kengo Sano, Naoto Sakaki, Katsuaki Kasahara, Katsumasa Kawata, Kenta Yashiro, Tsubasa Yoshioka, Maxim Pshirkov, Takeshi Okuda, Igor Tkachev, Naohiro Sone, and H. Oda

Published
2021

41. Reconstruction of air shower events measured by the surface detectors of the TAx4 experiment

Author

Fugo Yoshida, Fumio Kakimoto, Norimichi Shibata, Kinya Hibino, John Matthews, J. Yang, Y. Omura, Ivan Kharuk, Toshihiro Fujii, Hiroyuki Sagawa, Yuichiro Tameda, Hideki Tanaka, Yuma Shibasaki, Yuto Kubota, Hisono Tokuno, Mikhail Kuznetsov, Katsuaki Kasahara, Koichi Tanaka, Jon Paul Lundquist, M. Yamamoto, Katsumasa Kawata, Monica Allen, Bokkyun Shin, Hiroyuki Matsumiya, Tsubasa Yoshioka, Takafumi Uehama, Y. Nakamura, Kohei Yada, Yukio Uchihori, Hyomin Jeong, Tatsunobu Shibata, Ryota Onogi, J. H. Kim, Michiyuki Chikawa, ByongGu Cheon, Hideaki Shimodaira, Hyoming Jeong, Eiji Kido, M. Ohnishi, Taichi Inadomi, Kazuhiro Machida, Ryo Higuchi, Charlie Jui, Akitoshi Oshima, R. Mayta, Douglas Bergman, Keitaro Fujita, Elliott Barcikowski, Maxim Pshirkov, Manobu Tanaka, Pierre Sokolsky, Vladim Kuzmin, BayarJon Paul Lubsandorzhiev, Shunsuke Ozawa, Min Hyo Kim, Dmitri Ivanov, Koki Sato, Mayuko Minamino, Saori Kasami, Shigehiro Nagataki, Hideyuki Ohoka, Takashi Sako, K. Yamazaki, Tareq Abu-Zayyad, Keijiro Mukai, Youngjoon Kwon, Yasunori Saito, John Belz, Yana Zhezher, Sang Woo Kim, S. Kawakami, Jyunsei Chiba, Ryo Nakamura, Masato Takita, Yusuke Kimura, Daiki Shinto, Dongsu Ryu, Yuta Tanoue, Fumiya Shibata, Yuya Oku, K. H. Lee, Jihee Kim, Kengo Sano, Priti Shah, Hirokazu Iwakura, Y. Takagi, Motoki Hayashi, Oleg Kalashev, Kenta Yashiro, Zach Zundel, Masahiro Takeda, Ken Honda, Ben Stokes, Matt Potts, Kozo Fujisue, Stanton Thomas, Gordon Thomson, Toshiyuki Nonaka, Ryuhei Arimura, Ryosuke Tsuda, Akimichi Taketa, Tom Stroman, Robert Cady, Soomin Jeong, Ricardo Gonzalez, Federico R. Urban, Nobuyuki Sakurai, Koichi Sekino, Yoshiki Tsunesada, P. Tinyakov, Daisuke Ikeda, Eiji Nishio, T. Seki, Tomoyuki Nakamura, Ryota Fukushima, Naoya Inoue, Tiffany Wong, Toru Nakamura, Kenichi Kadota, Y. Takahashi, Mai Takamura, Masaki Fukushima, Takeshi Okuda, Igor Tkachev, Shingo Kawana, Naohiro Sone, Heungsu Shin, William Hanlon, H. Oda, Il Hung Park, G. Furlich, Takaaki Ishii, Hideyuki Kawai, Shinnosuke Kurisu, Yuto Arai, Toshio Matsuyama, Samuel Blake, Shoichi Ogio, Jeremy Smith, D. C. Rodriguez, Aoi Iwasaki, HangBae Kim, Ryota Fujiwara, Naoto Sakaki, Grigory Rubtsov, Rasha Abbasi, R. Sahara, Arata Nakazawa, Kei Nakai, Telescope Array, Isaac Myers, Hirotaka Ito, Ryuji Takeishi, Shoichi Kishigami, Masaomi Ono, Sergey Troitsky, Taka Tomida, J. Remington, Naoaki Hayashida, and Shigeharu Udo

Subjects
Surface (mathematics), Materials science, Optics, Air shower, business.industry, Detector, business
Published
2021

42. Effectiveness of direct acting antiviral agents for hepatitis C virus related recurrent hepatocellular carcinoma patients who had multiple courses of recurrence

Author

Hideo Yoshida, Eriko Goto, Koki Sato, Masatoshi Akamatsu, Mayuko Kondo, Takamasa Ohki, Takahisa Sato, Yuji Kondo, Shuntaro Obi, Yukihiro Koike, and Shinpei Sato

Subjects
Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Radiofrequency ablation, Hepatitis C virus, Hepacivirus, medicine.disease_cause, Gastroenterology, Antiviral Agents, law.invention, law, Virology, Internal medicine, Clinical endpoint, Medicine, Humans, Aged, Retrospective Studies, Hepatology, business.industry, Liver Neoplasms, Hepatitis C, Chronic, medicine.disease, Hepatitis C, Recurrent Hepatocellular Carcinoma, Discontinuation, Infectious Diseases, Hepatocellular carcinoma, Propensity score matching, Liver function, Neoplasm Recurrence, Local, business
Abstract

Eradication of hepatitis C virus (HCV) using direct acting antiviral agents (DAAs) has been reported to alter liver function and reduce the recurrence rate after curative treatment in naïve hepatocellular carcinoma (HCC) patients. However, it is not well known whether administration of DAAs had favourable effect on HCC patients with multiple courses of recurrence. We retrospectively extracted 146 HCV-related HCC (C-HCC) patients who received curative treatment using radiofrequency ablation (RFA) followed by eradication treatment with DAA between 1 January 2015 and 31 December 2017. We also extracted 184 C-HCC patients who were curatively treated using RFA without HCV eradication treatment between 1 January 2009 and 31 July 2014 as controls. We used propensity score matching method and adjusted following factors between the 2 groups: age, sex, liver function, number of recurrence times, tumour diameter and tumour numbers. We finally enrolled 47 C-HCC patients with eradication of HCV, and 47 C-HCC patients without HCV eradication as controls. Primary end point was time to curative treatment failure. We defined time to curative treatment failure as the interval from curative treatment initiation to premature discontinuation of this type of therapy. Their clinical data, time to curative treatment failure and overall survival were compared. We also assessed the prognostic values of time to curative treatment failure and overall survival using multivariate Cox proportional hazard models. The median age was 74.8 years, 60 patients (63.8%) were male, and 81 patients (86.2%) were Child-Pugh class A. The median tumour number was 1, tumour diameter was 20 mm, and frequency of recurrence was 3 times. There were no significant differences about patients' backgrounds between the 2 groups. The cumulative time to curative treatment failure rates of patients who received DAA were 93.6% and 73.2% at 1 and 3 years, respectively; those of controls were 72.5%, and 37.1% (p .01). Multivariate analysis indicated that eradication with DAAs (HR 0.23, 95% CI; 0.12-0.43, p .01) and DCP 50 mAU/ml (HR 2.62, 95% CI; 1.45-4.74, p .01) as independent factors contributed to time to curative treatment failure. The cumulative overall survival rates of patients who received DAAs were 93.6% and 72.6% at 1 and 3 years, respectively; those of controls were 72.8% and 37.4% (p .01). Multivariate analysis indicated that eradication with DAAs (HR 0.32, 95% CI; 0.17-0.60, p .01) and frequency of recurrence times (HR 1.20 per 1 time, 95% CI; 1.01-1.42, p = .038) as independent factors related to overall survival. Eradication of HCV using DAAs prolonged not only time to curative treatment failure but also overall survival even in C-HCC patients with multiple courses of recurrence.

Published
2021

43. Domino 1,4- and 1,6-Addition Reactions of Ketene Silyl Acetals to Dialkynyl Imines Promoted by Aluminum Chloride: Synthesis of Multifunctionalized β-Lactams

Author

Makoto Shimizu, Masaya Hara, Kenta Nakamura, Koki Sato, and Iwao Hachiya

Subjects
Addition reaction, Silylation, 010405 organic chemistry, Organic Chemistry, chemistry.chemical_element, Ketene, 010402 general chemistry, 01 natural sciences, Chloride, Medicinal chemistry, Domino, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Aluminium, β lactams, medicine, medicine.drug
Abstract

Domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines are disclosed. Aluminum chloride promoted domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines to give a variety of alkenyl iminocyclobutenones in moderate to good yields. The chemoselective reduction of alkenyl iminocyclobutenones and the subsequent thermal rearrangement of resulting alkenyl aminocyclobutenones in the presence of appropriate amines provided cis or trans multifunctionalized β-lactams in moderate to high yields with good to high diastereoselectivities.

Published
2019

44. Leakage Current and Chemical Potential Profile in Proton-Conducting Bi-Layered Solid Oxide Electrolyte with BZY and Hole-Blocking Layers

Author

Kazunari Sasaki, Gen Kojo, Hiroshige Matsumoto, Koki Sato, Hiroki Matsuo, Iinuma Hiroki, Yuya Tachikawa, Yoshio Matsuzaki, Junichiro Otomo, Yoshitaka Baba, and Shunsuke Taniguchi

Subjects
Materials science, business.industry, Oxide, chemistry.chemical_element, Electrolyte, Thermal conduction, Electrochemistry, chemistry.chemical_compound, Tungstate, chemistry, Lanthanum, Optoelectronics, Current (fluid), business, Electrical efficiency
Abstract

Solid oxide fuel cells (SOFCs) with proton-conducting solid electrolyte, instead of the oxide-ion conducting solid electrolyte have attracted attentions because of their high potential to reduce operating temperatures and to enhance the electrical efficiencies of SOFCs. In addition, the proton-conducting SOFCs with multistage electrochemical oxidation configuration will be promising technology for critically-high electric efficiencies. However, it is known that there are non-negligible charge -carriers other than protons in typical proton-conducting solid oxide electrolytes at relatively high temperatures. The existence of the partial conductivities of holes and/or electrons will cause the internal leakage current that consumes fuel but never generates any electrical power output. The higher ratio of the leakage current to external current will more deteriorate the electrical efficiency. In this study, the effects of blocking -layers formed on the air side surface of base electrolyte layer consisting of BaZr0.8Y0.2O3-δ (BZY82) for suppressing the leakage current have been investigated by using electrochemical parameters of the partial conduction of the materials. The chemical potential profile and leakage current showed large dependence on the material of the blocking -layer. Lanthanum tungstate was found to play a role as unique and strong blocking -layer against the leakage current.

Published
2019

45. Modified Energy Efficiencies of Proton‐conducting SOFCs with Partial Conductions of Oxide‐ions and Holes

Author

H. Iinuma, Koki Sato, Junichiro Otomo, Yuya Tachikawa, Yoshitaka Baba, Yoshio Matsuzaki, Kazunari Sasaki, Shunsuke Taniguchi, and Hiroshige Matsumoto

Subjects
chemistry.chemical_compound, Materials science, Proton, chemistry, Chemical engineering, Renewable Energy, Sustainability and the Environment, Oxide, Energy Engineering and Power Technology, Solid oxide fuel cell, Energy (signal processing), Ion
Published
2019

46. Is laparoscopic colorectal surgery with continuation of antiplatelet therapy safe without increasing bleeding complications?

Author

Hideki Ohdan, Ikki Nakashima, Manabu Shimomura, Haruki Sada, Masatoshi Kochi, Shoichiro Mukai, Kazuhiro Taguchi, Minoru Hattori, Koki Sato, Hiroyuki Egi, Yusuke Sumi, and Shintaro Akabane

Subjects
Adult, Male, medicine.medical_specialty, Blood Loss, Surgical, Propensity score method, Disease, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Blood loss, Surgical oncology, medicine, Humans, Propensity Score, Digestive System Surgical Procedures, Aged, Retrospective Studies, Aged, 80 and over, Aspirin, Surgical outcome, business.industry, Antiplatelet therapy, Incidence, General Medicine, Perioperative, Middle Aged, Colorectal surgery, Surgery, Treatment Outcome, Laparoscopic colorectal surgery, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, Female, Laparoscopy, Safety, business, Platelet Aggregation Inhibitors, Abdominal surgery, medicine.drug
Abstract

Purpose The number of patients on antiplatelet therapy (APT) who need surgery is increasing; however, it is unclear whether APT should be continued for abdominal surgery, particularly laparoscopic colorectal surgery. We investigated the safety of continuing APT for patients undergoing laparoscopic colorectal surgery. Methods We collected retrospective data from 529 patients who underwent laparoscopic colorectal surgery at Hiroshima University between January, 2013 and December, 2018. We analyzed information related to APT. Thirty-six pairs were matched by the propensity score method between patients on APT (APT+) and those not on APT (APT−). We compared the surgical outcomes of both groups. Results Among 463 patients eligible for the study, 48 were on APT for cerebrovascular or cardiovascular disease, and 36 continued to take aspirin. In the case-matched comparison, the amount of intraoperative blood loss in the APT+ group was not significantly higher than that in the APT− group, and the incidences of bleeding complications, thromboembolic complications, and other complications were not significantly different between the groups. Conclusion In a case-matched comparison, continuation of aspirin during laparoscopic colorectal surgery did not increase perioperative complications. In laparoscopic colorectal surgery, continuation of aspirin is an acceptable strategy for patients with thromboembolic risk caused by interruption of APT.

Published
2019

47. Risk Factors for Refractory Ascites After Living Donor Liver Transplant

Author

Yuki Imaoka, Yuka Tanaka, Hiroyuki Tahara, Koki Sato, Shinji Hashimoto, Seiichi Shimizu, Masahiro Ohira, Kentaro Ide, Tsuyoshi Kobayashi, Shintaro Kuroda, and Hideki Ohdan

Subjects
Adult, Male, medicine.medical_specialty, Poor prognosis, Severity of Illness Index, Gastroenterology, Living donor, Postoperative Complications, Risk Factors, Internal medicine, Severity of illness, Ascites, Living Donors, medicine, Humans, Survival rate, Aged, Retrospective Studies, Transplantation, business.industry, Incidence, Incidence (epidemiology), Graft Survival, Retrospective cohort study, Middle Aged, Liver Transplantation, Multivariate Analysis, Female, Surgery, Refractory ascites, medicine.symptom, business
Abstract

Refractory ascites after liver transplant commonly occurs in living donor liver transplant (LDLT). Refractory ascites is associated with postoperative complications and poor prognosis. This study sought to determine the risk factors of refractory ascites and discuss their perioperative management.A retrospective study of 122 living donor liver transplant recipients between 2008 and 2017 was performed to analyze the risk factors, incidence, and characteristics of refractory ascites. Refractory ascites post LDLT was defined as the production of ascites fluid1000 mL/d on postoperative day 14 or required repeated drainage.A total of 24 patients (19.6%) developed refractory ascites. The 1-year survival rate was significantly worse in the refractory ascites group compared with the nonrefractory ascites group (P .001). In a univariate analysis, patients with refractory ascites had a higher Model for End-Stage Liver Disease (MELD) score, donor age, presence of left lobe graft, ascites at laparotomy, portal venous pressure just after surgery, cold ischemia time, and absence of hepatocellular carcinoma compared with patients without refractory ascites. Multivariate proportional regression analyses revealed that MELD score ≥20, left lobe graft, donor age 50 years or older, and ascites at laparotomy ≥350 mL were independently associated with refractory ascites. Postoperative complications, such as bleeding (P .001), sepsis (P .001), and bloodstream infection within 30 days after LDLT (P .00), were significantly higher in the refractory ascites group.Refractory ascites is associated with reduced 1-year survival and increased postoperative complications. Four factors including MELD score ≥20, donor age 50 years or older, presence of left graft, and ascites at laparotomy ≥350 mL were independent predictors for refractory ascites.

Published
2019

48. Preparation of composite and hollow particles from self-assembled chitin nanofibers by Pickering emulsion polymerization

Author

Jun-ichi Kadokawa, Kazuya Yamamoto, Seiichiro Noguchi, and Koki Sato

Subjects
Materials science, Brachyura, Radical polymerization, Nanofibers, Emulsion polymerization, Chitin, 02 engineering and technology, Biochemistry, Polymerization, Styrene, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Animals, Molecular Biology, 030304 developmental biology, 0303 health sciences, technology, industry, and agriculture, General Medicine, 021001 nanoscience & nanotechnology, Dynamic Light Scattering, Pickering emulsion, chemistry, Chemical engineering, Emulsion, Emulsions, Polystyrene, 0210 nano-technology, Dispersion (chemistry)
Abstract

This study investigated Pickering emulsion polymerization of styrene using self-assembled chitin nanofibers (CNFs) as stabilizers to produce CNF-based composite particles, which were further converted into hollow particles. Previously, we reported that regeneration from a chitin/1‑allyl‑3‑methylimidazolium bromide ion gel using methanol fabricated self-assembled CNFs. Prior to the emulsion polymerization, CNFs were maleylated by reaction with maleic anhydride in the presence of perchloric acid. After styrene was added to a dispersion of the produced anionic CNFs in ammonia aq., a mixture was ultorasonicated to give an emulsion, in which styrene droplets were stably surrounded by CNFs. Radical polymerization was then conducted in the presence of potassium persulfate as an initiator to produce the composite particles. Particle sizes became smaller as the amounts of CNFs increased. The hollow particles were prepared by solubilizing out the polystyrene cores with toluene.

Published
2019

49. Preparation of Chitin Nanofiber-Reinforced Xanthan Gum Hydrogels

Author

Jun-ichi Kadokawa, Koki Sato, Akito Kawano, and Kazuya Yamamoto

Subjects
Environmental Engineering, Materials science, Morphology (linguistics), Polymers and Plastics, Cationic polymerization, 02 engineering and technology, 021001 nanoscience & nanotechnology, Chloride, Dimethyl acetal, chemistry.chemical_compound, 020401 chemical engineering, Chitin, chemistry, Chemical engineering, Nanofiber, Self-healing hydrogels, Materials Chemistry, medicine, 0204 chemical engineering, 0210 nano-technology, Xanthan gum, medicine.drug
Abstract

In this study, chitin was nanofibrillated, cationized, and then used as a reinforcing agent for xanthan gum hydrogels. Amidinated chitin nanofibers (CNFs), which were prepared by partial deacetylation of the nanofibrillated chitin and the subsequent reaction of the generated amino groups with N,N-dimethylacetamide dimethyl acetal, were converted into an amidinium chitin bicarbonate with nanofiber morphology by CO2 gas bubbling and ultrasonic treatments in water. Xanthan gum hydrogels, which were prepared by exchange of disperse media from xantham gum ion gels with 1-butyl-3-methylimidazolium chloride, were then soaked in the resulting cationic CNF aqueous dispersions with different degrees of substitution (DSs) of amidinium groups to progress composition, giving rise to the CNF-reinforced xanthan gum hydrogels. The presence of CNFs in the hydrogels was confirmed by SEM measurement of the lyophilized samples. The amounts of CNFs in the hydrogels increased with increasing the DS values. The compression testing of the hydrogels suggested the reinforcing effect of CNFs, which were induced by electrostatic interaction owing to anionic nature of xanthan gum.

Published
2019

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