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Sleep disorders are one of the causes that impair our quality of life, and adjustment of autonomic nervous activity can improve the sleep quality. The authors examined the effects on the sleep quality with adjustment of autonomic nervous activity by individually optimizing complex environment before sleep. Sixteen subjects underwent an environment optimization experiment during the day and subsequent sleep experiment (9 days/individual) and the ratio of low-frequency to high-frequency (LF/HF) components of heart rate variability was measured during the experiment. The LF/HF decreased under optimal conditions by 19% compared to the control conditions. Next, the effects of optimal conditions before sleep on the sleep quality were evaluated. Based on the index for the sleep quality (light sleep index), effect of the optimal environment conditions before sleep was not clearly observed for all subjects. Clustering analysis was evaluated to analyze the cause deeply. As a result, for the group of experiment subjects who did not feel nervous about the experiment, the light sleep index was decreased under optimal conditions by 29% compared to the control conditions. It was found that the effect on such stimuli could disappear in the subjects who were nervous about the experiment.

BACKGROUND: T(1ρ) has been extensively reported as a sensitive biomarker of biochemical changes in the nucleus pulposus (NP) and annulus fibrosis of intervertebral discs (IVDs). However, no T(1ρ) study of cartilaginous endplates (CEPs) has yet been reported because the relatively long echo times (TEs) of conventional clinical T(1ρ) sequences cannot effectively capture the fast-decaying magnetic resonance signals of CEPs, which have very short T(2)/T(2)*s. This can be overcome by using ultrashort echo time (UTE) T(1ρ) acquisitions. METHODS: Seventeen subjects underwent UTE with adiabatic T(1ρ) preparation (UTE-Adiab-T(1ρ)) and T(2)-weighted fast spin echo imaging of their lumbar spines. Each IVD was manually segmented into seven regions (i.e., outer anterior annulus fibrosis, inner anterior annulus fibrosis, outer posterior annulus fibrosis, inner posterior annulus fibrosis, superior CEP, inferior CEP, and NP). T(1ρ) values of these sub-regions were correlated with IVD modified Pfirrmann grades and subjects’ ages. In addition, T(1ρ) values were compared in subjects with and without low back pain (LBP). RESULTS: Correlations of T(1ρ) values of the outer posterior annulus fibrosis, superior CEP, inferior CEP, and NP with modified Pfirrmann grades were significant (P

ObjectivesThe purpose of this study was to measure the indices of radiographic developmental dysplasia of the hip (DDH) in a cross-sectional study of an elderly Japanese population.MethodsHip radiographs of 427 informed, voluntary Japanese community-dwelling individuals (279 female and 148 male) aged 50–96 years-old were obtained from Miyagawa village in Japan through a health screening. The hip radiographs were measured by a custom-written, semi-automated MATLAB program. The center edge (CE) angle, acetabular roof obliquity (ARO), acetabular head index (AHI), and minimum joint space width (mJSW) were measured. We examined the associations between gender, side-of-hip, and age group on radiographic DDH and hip osteoarthritis (OA).ResultsThe mean CE angle was 31.0°. The mean ARO was 5.8°. The mean AHI was 88.2%. The mean mJSW was 4.0 mm. Of the total population, 29.9% had DDH and 4.0% had hip OA. Of those who had hip OA, 41.2% were secondary OA, and 58.8% were primary OA. The relationship between DDH and OA was not significant.ConclusionDDH is unlikely to be an important cause of hip OA in the present population-based study.

Purpose We aimed to use magnetic resonance imaging (MRI) to determine the relationship between the pathological depth of invasion (DOI), undetectability, and tumor thickness of squamous cell carcinoma of the floor of the mouth. Materials and methods We retrospectively evaluated the relationship between pathological DOI and MRI detectability, as well as the relationship between pathological DOI and tumor thickness on coronal fat-suppressed contrast-enhanced T1-weighted imaging or coronal T2-weighted imaging. Results We analyzed 30 patients with squamous cell carcinoma of the floor of the mouth; MRI revealed that the pathological DOI of the 11 undetectable lesions (median 2 mm) was smaller than that of the 19 detectable lesions (median 14 mm) (p Conclusions Undetectability on MRI indicates superficial lesions with a pathological DOI value that is less than 3 mm. In detectable lesions, tumor thickness on coronal fat-suppressed contrast-enhanced T1-weighted imaging is associated with pathological DOI.

Background Endovascular therapy (ET) for delayed post-pancreatectomy hemorrhage (PPH) involves the risk of hepatic artery occlusion (HAO). Nonetheless, the development of extrahepatic collateral circulation (EHC) and relationship between radiological factors (EHC, portal vein stenosis, and HAO) and adverse hepatic events after ET remain unclear. This study aimed to evaluate the efficacy and safety of ET for delayed PPH and examine the development of EHC. Methods A total of 19 ET cases for delayed PPH were reviewed. Hepatic adverse events, portal vein stenosis, HAO, and mortality rate after ET were evaluated. Moreover, EHC from the left gastric artery (LGA), right inferior phrenic artery (RIPA), left inferior phrenic artery (LIPA), right internal thoracic artery (RITA), left internal thoracic artery (LITA), renal artery (RA), omental artery (OA), intercostal artery (IA), and branch of superior mesenteric artery (BSMA) was assessed using angiogram and computed tomography angiography (CTA). Results All cases were successfully treated using transcatheter arterial embolization (n = 17) and stent-graft placement (n = 2) without mortality. EHC from the LGA (8/19), RIPA (10/19), LIPA (4/19), and RITA (3/19) was observed on post-ET CTA. The incidence of hepatic adverse event was significant in the group with both HAO and portal vein stenosis (p

This paper describes motion behaviors of a floating body and water regions of moonpools. The floating model to be focused in this study has moonpools and is for offshore wind turbine system with two vertical axis wind turbines. Motion behaviors of water region in moonpools strongly affect on motion characteristics of a floating body itself. Often the effects lead to non-linear motion of the floating body. Besides, when the floating body is a system of vertical axis offshore wind turbines, the system becomes more complicated. This study conducted theoretical calculations and model experiments in a wave tank. Behaviors of moonpools were measured in regular waves and we measured wave exciting forces, radiation forces on heave and motion responses of the floating model. Also, the study considered effects of Vertical Axis Wind Turbine (VAWT) model’s rotation on the motion. From the results behaviors of moonpools were often nonlinear to incident waves and the behaviors affected on motion responses of the floating model. The experimental results were compared with the calculation results. When non-linearity due to overtopping of water from moonpools was found, the calculations could not reproduce hydro forces but they are able to estimate motion responses. The study confirmed reduction effects due to the moonpools on motion responses comparing with a conventional pontoon with identical displacement.

The objective of this study was to determine correlations between magnetic resonance imaging (MRI) features including radiologic depth of invasion (r-DOI) and pathologic DOI (p-DOI) of squamous cell carcinoma of the buccal mucosa.In total, 31 lesions were retrospectively evaluated. MRI findings included detectability, buccinator muscle invasion (positive: BMI+, negative: BMI-), buccal fat pad invasion (positive: BFPI+, negative: BFPI-), and r-DOI measured on T2-weighted images (T2-DOI) and contrast-enhanced T1-weighted images (CET1-DOI). These findings were compared to the p-DOI of the tumors.The p-DOI values of undetectable lesions were smaller than those of detectable lesions (P.001), and the cutoff value was 1 mm. BMI+ and BFPI+ lesions had significantly larger p-DOI values than the corresponding BMI- and BFPI- lesions (P.001), with cutoff values of 5 and 6 mm, respectively. The correlation coefficient between CET1-DOI and p-DOI was 0.68 (P.001). CET1-DOI values were larger than p-DOI (P.001) and the average difference between them was 3.4 mm. T2-DOI was inconclusive in 50% of cases. Interobserver agreements of MRI evaluation were good to very good.MRI-derived parameters were useful in estimating p-DOI and may be helpful in predicting the depth of invasion of tumors and the risk of lymph node metastasis.

Background Peripheral nerve damage can have debilitating consequences. Rabbit sciatic nerve transection models allow the effective evaluation of surgical repair strategies for large nerve gaps. Despite advantages in size, ease of handling, and functional utility, rabbits can suffer from a number of side effects that affect animal welfare and the quality of scientific inquiry. Such side-effects, which include pressure ulcers and traumatic damage to the foot, are primarily a consequence of insensitivity of the distal hindlimb following sciatic nerve injury. In this study, we present a number of methodologies for identifying, treating, and preventing unintended adverse effects in rabbit sciatic nerve injury models. Results First, we categorize pressure ulcers according to their severity and describe the deployment of a padded bandaging technique to enable ulcer healing. We also introduce a proactive bandaging approach to reduce the likelihood of pressure ulcer formation. Second, we define phenotypes that distinguish between foot injuries resulting from self-mutilation (autotomy) from those caused by incidental traumatic injury secondary to sensori-motor damage. Finally, we detail an effective strategy to reduce the usage of Elizabethan collars; through a gradual weaning protocol, their usefulness in preventing autotomy is retained, while their propensity to impede rabbit grooming and cause abrasion-injury to the neck region is minimized. Conclusions We suggest that application of these methods offer a practical and systematic approach to avoid adverse side effects associated with rabbit sciatic nerve damage, enabling improved animal welfare and scientific outcomes in a powerful nerve injury model.

Despite considerable research effort, there is a significant need for safe agents that stimulate bone formation. Treatment of large or complex bone defects remains a challenge. Implantation of small molecule-induced human bone marrow-derived mesenchymal stromal cells (hBMSCs) on an appropriate tricalcium phosphate (TCP) scaffold offers a robust system for noninvasive therapy for spinal fusion. To show the efficacy of this approach, we identified a small molecule curcuminoid that when combined with TCP ceramic in the presence of hBMSCs selectively induced growth of bone cells: after 8- or 25-day incubations, alkaline phosphatase was elevated. Treatment of hBMSCs with curcuminoid 1 and TCP ceramic increased osteogenic target gene expression (i.e., Runx2, BMP2, Osteopontin, and Osteocalcin) over time. In the presence of curcuminoid 1 and TCP ceramic, osteogenesis of hBMSCs, including proliferation, differentiation, and mineralization, was observed. No evidence of chondrogenic or adipogenic potential using this protocol was observed. Transplantation of curcuminoid 1-treated hBMSC/TCP mixtures into the spine of immunodeficient rats showed that it achieved spinal fusion and provided greater stability of the spinal column than untreated hBMSC-TCP implants or TCP alone implants. On the basis of histological analysis, greater bone formation was associated with curcuminoid 1-treated hBMSC implants manifested as contiguous growth plates with extensive hematopoietic territories. Stimulation of hBMSCs by administration of small molecule curcuminoid 1 in the presence of TCP ceramic afforded an effective noninvasive strategy that increased spinal fusion repair and provided greater stability of the spinal column after 8 weeks in immunodeficient rats. IMPACT STATEMENT: Bone defects only slowly regenerate themselves in humans. Current procedures to restore spinal defects are not always effective. Some have side effects. In this article, a new method to produce bone growth within 8 weeks in rats is presented. In the presence of tricalcium phosphate ceramic, curcuminoid-1 small molecule-stimulated human bone marrow-derived mesenchymal stromal cells showed robust bone cell growth in vitro. Transplantation of this mixture into the spine showed efficient spinal fusion in rats. The approach presented herein provides an efficient biocompatible scaffold for delivery of a potentially clinically useful system that could be applicable in patients.

The loss of nucleus pulposus (NP) notochordal cells is one of the key initial hallmarks of age-related intervertebral disc degeneration. Although the transmembrane mechanoreceptor integrin α5β1 is important in the process of disc degeneration, the relationship between integrin α5β1 and notochordal cell disappearance remains unclear. The purpose of this study was to elucidate the role of integrin α5β1 in the homeostasis of notochordal cells using an ex-vivo dynamic loading culture system that we developed. Rat tail functional spinal units (n = 80 from 40 rats) were cultured under unloading or 1.3-MPa, 1.0-Hz dynamic compressive loading for 48 or 144 h with or without an integrin α5β1 inhibitor. Disc histomorphology, cell viability, apoptosis, senescence, and phenotypic expression were investigated. Consequently, histological degenerative disc changes with decreased cell viability and increased cell apoptosis and senescence were observed with an extended loading duration. Immunofluorescence revealed that the expression of notochordal cell markers, CD24 and brachyury, and chondrocyte markers, collagen type II and SRY-box 9, declined with loading. In particular, reduction in notochordal cell marker expression was more dramatic than that in chondrocyte marker expression. Apoptotic terminal deoxynucleotidyl transferase dUTP nick-end labeling positivity was also higher in brachyury-positive notochordal cells. Furthermore, all these changes were delayed by inhibiting integrin α5β1. Findings of our dynamic loading regimen with a relatively high pressure suggest reproducibility of the cellularity and phenotypic disappearance of NP notochordal cells during adolescence, the susceptibility of notochordal cells to mechanical stimuli partially through the integrin α5β1 pathway, and future potential treatment of integrin regulation for intervertebral disc disease.

Mediastinum hematoma is often caused by chest trauma, aortic dissection, and tumor. Spontaneous nontraumatic middle mediastinum hematoma is a rare and potentially life-threatening condition. Here, we report the case of a patient who was a 46-year-old experienced sudden chest pain with spontaneous middle mediastinum hematoma caused by rupture of the bilateral bronchial artery. We successfully treated the patient with transcatheter arterial embolization via the bilateral bronchial artery using N-butyl-2-cyanoacrylate.

The refractory lining in a furnace is always damaged and peels off when spent lithium-ion secondary batteries (LIB) are pyro-processed in a rotary kiln. To develop highly durable refractories and to elucidate the erosion behavior, various analyses such as scanning electron microscopy/energy dispersive X-ray spectroscopy, laser-induced breakdown spectroscopy, inductively coupled plasma atomic emission spectroscopy, ion chromatography, and X-ray diffraction were performed on the linings sampled from different sections of a refractory. Our results suggested the following mechanisms in Al2O3–SiO2–CaO refractory damage during pyro-processing of spent LIB packs. First, Li2O, P2O5, LiF, and HF were formed by thermal decomposition of electrolyte constituents of the lithium-ion secondary batteries. When HF reacts with SiO2, Al2O3, and CaO on the surface of the refractory, each fluoride that forms vaporizes and melts. When Li2O and P2O5 (as well as LiF) react with the Al2O3–SiO2 refractory, an Li2O–Al2O3–SiO2–P2O5(-LiF) phase with a low melting point forms and penetrates into the refractory through pores, grain boundaries, and cracks, resulting in peeling off.

Ultra-short echo time (UTE) MRI with post-processing is a promising technique in bone imaging that produces a similar contrast to computed tomography (CT). Here, we propose a 3D slab-selective ultrashort echo time (UTE) sequence together with image post-processing to image bone structures in the lumbar spine. We also explore the intermodality agreement between the UTE and CT images. The lumbar spines of two healthy volunteers were imaged with 3D UTE using five different resolutions to determine the best imaging protocol. Then, four patients with low back pain were imaged with both the 3D UTE sequence and CT to investigate agreement between the imaging methods. Two other patients with low back pain were then imaged with the 3D UTE sequence and clinical conventional T1-weighted and T2-weighted fast spin-echo (FSE) MRI sequences for qualitative comparison. The 3D UTE sequence together with post-processing showed high contrast images of bone and high intermodality agreement with CT images. In conclusion, post-processed slab-selective UTE imaging is a feasible approach for highlighting bone structures in the lumbar spine and demonstrates significant anatomical correlation with CT images.

Background Endovascular therapy (ET) for delayed hepatic artery post-pancreatectomy hemorrhage (HA-PPH) may require complete hepatic artery occlusion (HAO). Nonetheless, the development of extrahepatic collateral circulation (EHC) and the relationship between radiological factors (EHC, portal vein stenosis, and HAO) and adverse hepatic events after ET remain unclear. This study aimed to evaluate the efficacy and safety of ET for delayed PPH and examine the development of EHC. Methods A total of 19 ET cases for delayed HA-PPH were reviewed. Hepatic adverse events, portal vein stenosis, HAO, and mortality rate after ET were evaluated. Moreover, EHC from the left gastric artery (LGA), right inferior phrenic artery (RIPA), left inferior phrenic artery (LIPA), right internal thoracic artery (RITA), left internal thoracic artery (LITA), renal artery (RA), omental artery (OA), intercostal artery (IA), and branch of superior mesenteric artery (BSMA) was assessed using angiogram and computed tomography angiography (CTA). Results All cases were successfully treated using transcatheter arterial embolization (n = 17) and stent-graft placement (n = 2) without mortality. EHC from the LGA (8/19), RIPA (10/19), LIPA (4/19), and RITA (3/19) was observed on post-ET CTA. The incidence of hepatic adverse events was significant in the group with both HAO and portal vein stenosis (p < 0.001) and absence of EHC from LIPA and RITA (p < 0.05). Conclusion ET for delayed HA-PPH might be effective and safe. While avoiding both HAO and portal vein stenosis is important, the development of EHCs from LIPA and RITA may prevent hepatic adverse events after ET.

While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes’ expression, among which are inflammatory cytokines, in many tissues including the IVD. NF-κB decoy is an oligodeoxynucleotide containing the NF-κB binding site that entraps NF-κB subunits, resulting in suppression of NF-κB activity. In the present preclinical study, NF-κB decoy was injected into degenerated IVDs using the rabbit anular-puncture model. In terms of distribution, NF-κB decoy persisted in the IVDs up to at least 4 weeks after injection. The remaining amount of NF-κB decoy indicated that it fit a double-exponential-decay equation. Investigation of puncture-caused degeneration of IVDs showed that NF-κB decoy injection recovered, dose-dependently, the reduced disc height that was associated with reparative cell cloning and morphological changes, as assessed through histology. Gene expression, by quantitative real-time polymerase chain reaction (qRT-PCR), showed that NF-κB decoy attenuated inflammatory gene expression, such as that of interleukin-1 and tumor necrosis factor-α, in rabbit degenerated IVDs. NF-κB decoy also reduced the pain response as seen using the “pain sensor” nude rat xenograft-radiculopathy model. This is the first report demonstrating that NF-κB decoy suppresses the inflammatory response in degenerated IVDs and restores IVD disc height loss. Therefore, the intradiscal injection of NF-κB decoy may have the potential as an effective therapeutic strategy for discogenic pain associated with degenerated IVDs.

This paper describes the motion characteristics and cargo handling efficiency of the Large-Scale Floating Coal Transshipment Station (LFTS). Indonesia is the main country supplying coal in the Asia-Pacific region, it is important to ensure stable coal supply to Japan. Because the topography of the seabed near East Kalimantan Island, Indonesia’s main coal production area, is shallow, it is difficult for bulk carriers to reach the coast. And then, Large-scale Floating Transposition Station for Loading Coal (hereafter LFTS) was proposed, which will be used as a transposition station between small coal barge coming down the river and bulk carriers stay offshore. By installing LFTS, improvement of coal transport efficiency is expected. As a previous study, the motion characteristics of LFTS using a catenary chain in its mooring system were grasped. However, LFTS can carry up to 500,000 tons of coal, and the draft of LFTS tends to change greatly depending on the coal loading conditions. Besides, the tidal difference in the sea area where the LFTS is installed is about 2 m, and the mounting position of the mooring system on the LFTS side moves up and down by about 10 m at maximum due to changes in the draft and tidal differences. For this reason, when the mounting position of the mooring system is in the lowest state, the mooring line is loosened and the horizontal force is reduced, and it is considered that sufficient restraining force is not exhibited. And, when the mounting position of the mooring system becomes high, the mooring line tension increases and the mooring line may break in some cases. Therefore, in this study, an attempt was made to use an elastic mooring line as a mooring system for LFTS. An elastic mooring line is a mooring line that incorporates a highly stretchable material between mooring lines that connect anchors and floating body. Even if the mooring line attached to the LFTS moves up and down, an appropriate tension always acts on the elastic mooring line, and it can be expected to suppress the oscillation of the floating body and prevent the mooring line from breaking due to excessive tension. However, elastic mooring lines are mainly used for mooring small structures such as piers and aquaculture facilities, but there are no examples where these mooring lines have been applied to structures over 500m like LFTS. Therefore, elastic mooring lines are adopted for the mooring system of LFTS, systematically calculated according to various setting conditions of elastic mooring lines, and it is grasped whether elastic mooring lines can be applied to LFTS, and the motion characteristics of LFTS moored by elastic mooring lines was also grasped.

Indonesia is the main country supplying coal in the Asia-Pacific region, and in order to secure a stable supply of coal to neighboring countries, efficient coal transportation is required. East Kalimantan Island in Indonesia is the main coal-producing area, but the sea around the island is very shallow and bulk carriers for transporting coal cannot approach the coast. And then, Large-scale Floating Transposition Station for Loading Coal (hereafter LFTS) was proposed, which will be used as a transposition station between small coal barge coming down the river and bulk carriers that stays offshore. LFTS has a two-dimensional extent, and because the bulkheads for separating coal according to quality are installed on the floating body, the rigidity is partially different, and the draft also changes greatly according to the coal loading condition. In this way, LFTS has different characteristics from Mega-Float, which was built in Japan in the late 1990s with the aim of realizing a floating airport, so it is important to clarify its structural characteristics. In order to grasp the stress distribution acting on the structural member in consideration of the influence of the interaction between the overall deformation and the local deformation of LFTS, an analysis in which the entire structure is modeled in detail is desired. However, because members such as the internal bulkheads are arranged in a complicated manner in LFTS, a model in which the entire structure is modeled in detail requires enormous calculation costs in both capacity and time, it is difficult to perform the analysis. In existing research, various models have been studied, but there remains a problem in setting boundary conditions that reproduce the interaction between global and local deformations. And then, in this paper, a new modeling method of LFTS that can be analyzed efficiently was proposed. And the occurrence of stress concentration in the structural members of the LFTS was identified by systematically changing the external force conditions such as the coal loading condition and wave load assumed during the operation of the LFTS, and performing LFTS oscillation analysis and stress deformation analysis. Furthermore, the occurrence of plastic strain due to large deformation was investigated. The stiffening method that efficiently suppresses the occurrence of plastic strain was studied for the locations where the plastic strain was identified by the above analysis. These results demonstrate the importance of modeling large floating structures with complex structures.

This perspective summarizes the genesis, development, and potential future directions of the multispeciesJOR Spinehistopathology series.

Barge-type platforms with moonpools are a promising type of foundation for floating offshore wind turbines due to their good seakeeping performance. In this paper, the mean wave drift force on a barge-type vertical-axis floating wind turbine with multiple moonpools was investigated through physical model testing and numerical calculations using WAMIT. The focus was on the characteristics of mean drift load and its optimization potential. The present numerical results indicated that the application of moonpools was useful in reducing horizontal mean drift force at specific frequencies, and the reason was ascribed to the significant radiation effect of the resonant water oscillations in moonpools. The observed reduction effect on mean drift force was shown to be dependent on the viscous damping of moonpool resonance. The experimental results showed that the maximum response of the mean sway drift force was reduced by the gyroscopic effect of rotations of the vertical-axis wind turbine, and this reduction effect became stronger as the rotating speed of the wind turbine increased, but was weakened as wave amplitude increased. The comparisons between experimental data and potential flow predictions indicated that viscous effects should be taken into account to reasonably estimate the mean wave drift forces on barge-type floating wind turbines.

Wave energy converters (WECs) have been extensively researched. The behaviour of the oscillating water column (OWC) in OWC WECs is extremely complex due to the interaction of waves, air, and turbines. Several problems must be overcome before such WECs can be put to practical use. One problem is that the effect of the difference in scale between a small-scale experimental model and a full-scale model is unclear. In this study, several OWC models with different scales and geometries were used in forced oscillation tests. The wave tank was 7.0 m wide, 24.0 m long, and 1.0 m deep. In the static water experiment, we measured the air pressure and water surface fluctuations in an air chamber. For the experiments, models with a box shape with an open bottom, a manifold shape with an open bottom, and a box shape with a front opening, respectively, were fabricated. Furthermore, 1/1, 1/2, and 1/4 scale models were fabricated for each shape to investigate the effects of scale and shape on the air chamber characteristics. Numerical calculations were carried out by applying linear potential theory and the results were compared with the experimental values. The results confirmed that the air chamber shape and scale affect the air pressure fluctuation and water surface fluctuation inside the OWC system.

Numerical simulation based on the moving particle semi-implicit (MPS) method is effective for the analysis of floating motion in stormy waves in both coastal and offshore areas. However, when the outer circumference of the calculation area is composed of wall boundaries, superimposed waves are generated by the reflected waves, which makes it difficult to reproduce wave fields in offshore areas. Therefore, in this study, we developed two types of non-reflective boundary that can be applied to a numerical wave tank with the MPS method. One type is an attenuation zone in which a high-viscosity region with a finite width is set from the end of the water tank. The other type is a wave absorption control boundary that detects the amount of water surface fluctuation in front of the boundary and prevents reflection via position control. Regular and irregular waves were created in a numerical wave tank with these boundaries and the wave dissipation performance was quantitatively evaluated by comparing the estimates for incident and reflected waves, the time-series waveform, and the wave spectrum.

The barge-type foundation with moonpool(s) is a promising type of platform for floating offshore wind turbines, since the moonpool(s) could improve the hydrodynamic performance at particular frequencies and reduce the costs of construction. In this paper, the horizontal mean drift force and yaw drift moment of a barge-type platform with four moonpools are numerically and experimentally investigated. Physical model tests are carried out in a wave tank, where a 2MW vertical-axis wind turbine is modelled in the 1:100 scale. By varying the rotating speed of the turbine and the mass of the blades, the gyroscopic effects due to turbine rotations on the mean drift forces are experimentally examined. The wave diffraction and radiation code WAMIT is used to carry out numerical analysis of wave drift force and moment. The experimental results indicate that the influence of the rotations of a vertical-axis wind turbine on the sway drift force is generally not very significant. The predictions by WAMIT are in reasonable agreement with the measured data. Numerical results demonstrate that the horizontal mean drift force and yaw drift moment at certain frequencies could be reduced by moonpool(s).

When a large-scale tsunami occurs, structures in the coastal area will be destroyed by the impact of tsunami drifts. In the design of tsunami evacuation facilities and petroleum complexes, it is necessary to estimate the impact force of tsunami drift, which varies in size, shape and mass. Although some design equations have been proposed to estimate the impact force of tsunami drift, the impact force varies depending on various conditions such as the draft of the tsunami drifts, the attitude of the collision, the condition of the surrounding flow field, and the rigidity of the structure, etc. No reasonable design equation has been developed yet to meet all these conditions. Therefore, it is necessary to estimate the impact force of tsunami drift by water tank experiments and numerical simulations. In order to simulate the impact of a tsunami drift on a structure by numerical simulation, it is necessary to solve the coupling of fluid, floating object and structure. In this study, we have developed a simulation system that can simulate the impact force of a tsunami drift with the MPS method, which is a kind of particle method. This simulation system introduces an explicit method for pressure calculation, which allows for relatively large scale numerical calculations. In addition, the system is able to reproduce the deformation of structures as an elastic body due to the impact of tsunami drift. In particular, we have introduced an analytical method that allows us to set the computational time step that satisfy the CFL conditions for elastic and fluid particles, respectively, for stable simulation even when there is a large difference between the velocity of fluid particles and the velocity of structural particles caused by elastic waves. As a result of the comparison of the impact force on the cantilevered beam of the tsunami drift with the simulation and the water tank test, the deformation of the structure at the time of impact was reproduced with more than 90% accuracy.

Ultrashort echo time (UTE) sequences can image tissues with transverse T(2)/T(2)* relaxations too short to be efficiently observed on routine clinical MRI sequences, such as the vertebral body cartilaginous endplate (CEP). Here, we describe a 3D adiabatic inversion recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence to highlight the CEP of vertebral bodies in comparison to the intervertebral disc (IVD) and bone marrow fat (BF) at 3T. The IR-FS-UTE sequence used a 3D UTE sequence combined with an adiabatic IR preparation pulse centered in the middle of the water and fat peaks, while a fat saturation module was used to suppress the signal from fat. A slab-selective half pulse was used for signal excitation, and a 3D center-out cones trajectory was used for more efficient data sampling. The 3D IR-FS-UTE sequence was applied to an ex vivo human spine sample, as well as the spines of six healthy volunteers and of three patients with back pain. Bright continue lines representing signal from CEP were found in healthy IVDs. The measured contrast-to-noise ratio (CNR) was 18.5±4.9 between the CEP and BF, and 20.3±4.15 between the CEP and IVD for the six volunteers. Abnormal IVDs showed CEP discontinuity or irregularity in the sample and patients’ studies. In conclusion, the proposed 3D IR-FS-UTE sequence is feasible for imaging of the vertebral body’s CEP in vivo with high contrast.

Rotator cuff (RC) tears present a treatment challenge due to muscle atrophy and degeneration, fatty infiltration, and fibrosis. The purpose of this study was to generate a high time-resolution model of RC tear in rabbits and to characterize the progression of architectural and histological changes. Thirty-five female New Zealand White rabbits (age: 6 months) underwent left supraspinatus tenotomy. Five rabbits were used to evaluate immediate muscle architectural changes. The remaining 30 rabbits underwent right shoulder sham surgery and sacrifice at 1, 2, 4, 8, or 16 weeks. Histology was used to quantify muscle fiber cross-sectional area (CSA), muscle degeneration and regeneration, and fat localized to inter- versus intrafascicular regions. Muscle fiber CSA decreased by 26.5% compared to sham at 16 weeks (effect of treatment, p

Background The rabbit lumbar spine is a commonly utilized model for studying intervertebral disc degeneration and for the pre‐clinical evaluation of regenerative therapies. Histopathology is the foundation for which alterations to disc morphology and cellularity with degeneration, or following repair or treatment are assessed. Despite this, no standardized histology grading scale has yet been established for the spine field for any of the frequently utilized animal models. Aims The purpose of this study was to establish a new standardized scoring system to assess disc degeneration and regeneration in the rabbit model. Materials and Methods The scoring system was formulated following a review of the literature and a survey of spine researchers. Validation of the scoring system was carried out using images provided by 4 independent laboratories, which were graded by 12 independent graders of varying experience levels. Reliability testing was performed via the computation of intra‐class correlation coefficients (ICC) for each category and the total score. The scoring system was then further refined based on the results of the ICC analysis and discussions amongst the authors. Results The final general scoring system involves scoring 7 features (nucleus pulposus shape, area, cellularity and matrix condensation, annulus fibrosus/nucleus pulposus border appearance, annulus fibrosus morphology, and endplate sclerosis/thickening) on a 0 (healthy) to 2 (severe degeneration) scale. ICCs demonstrated overall moderate to good agreement across graders. An addendum to the main scoring system is also included for use in studies evaluating regenerative therapeutics, which involves scoring cell cloning and morphology within the nucleus pulposus and inner annulus fibrosus. Discussion Overall, this new scoring system provides an avenue to improve standardization, allow a more accurate comparison between labs and more robust evaluation of pathophysiology and regenerative treatments across the field. Conclusion This study developed a histopathology scoring system for degeneration and regeneration in the rabbit model based on reported practice in the literature, a survey of spine researchers, and validation testing., The rabbit lumbar spine is a commonly utilized model for studying intervertebral disc degeneration and for the pre‐clinical evaluation of regenerative therapies, and histopathology is the foundation for which alterations to disc morphology and cellularity with degeneration, or following repair or treatment are assessed. Despite this, no standardized histology grading scale has yet been established for the spine field for any of the frequently utilized animal models. Therefore, the purpose of this study was to establish a new standardized scoring system to assess disc degeneration and regeneration in the rabbit model.

Low back pain (LBP) is now regarded as the first cause of disability worldwide and should be a priority for future research on prevention and therapy. Intervertebral disc (IVD) degeneration is an important pathogenesis of LBP. Platelet-rich plasma (PRP) is an autologous blood concentrate that contains a natural concentration of autologous growth factors and cytokines and is currently widely used in the clinical setting for tissue regeneration and repair. PRP has great potential to stimulate cell proliferation and metabolic activity of IVD cells in vitro. Several animal studies have shown that the injection of PRP into degenerated IVDs is effective in restoring structural changes (IVD height) and improving the matrix integrity of degenerated IVDs as evaluated by magnetic resonance imaging (MRI) and histology. The results of this basic research have shown the great possibility that PRP has significant biological effects for tissue repair to counteract IVD degeneration. Clinical studies for evaluating the effects of the injection of PRP into degenerated IVDs for patients with discogenic LBP have been reviewed. Although there was only one double-blind randomized controlled trial, all the studies reported that PRP was safe and effective in reducing back pain. While the clinical evidence of tissue repair of IVDs by PRP treatment is currently lacking, there is a great possibility that the application of PRP has the potential to lead to a feasible intradiscal therapy for the treatment of degenerative disc diseases. Further large-scale studies may be required to confirm the clinical evidence of PRP for the treatment of discogenic LBP.

Hepatic artery aneurysms are rare and sometimes life-threating. Various treatments for hepatic artery aneurysms, including surgical and endovascular techniques are present. Here, we report the case of a 68-year-old woman who presented with an about 9 cm of common hepatic artery aneurysm detected during a routine medical checkup; she did not exhibit any symptoms. We successfully treated the aneurysm with transcatheter arterial embolization with isolation technique via pancreatic duodenal arcade. Keywords: Common hepatic artery aneurysm, Transcatheter arterial embolization, Isolation technique via pancreaticoduodenal arcade

BACKGROUND: While conventional MRI sequences cannot visualize tissues from the osteochondral junction (OCJ) due to these tissues’ short transverse T(2)/T(2)* relaxations, ultrashort echo time (UTE) sequences can overcome this limitation. A 2D UTE sequence with a dual adiabatic inversion recovery preparation (DIR-UTE) for selective imaging of short T(2) tissues with high contrast has previously been developed, but high sensitivity to eddy currents and aliased out-of-slice excitation make it difficult to image the thin layer of the OCJ in vivo. Here, we combine the DIR scheme with a 3D UTE Cones sequence for volumetric imaging of OCJ tissues in vivo, aiming to generate higher OCJ contrast compared with a recently developed single IR-prepared UTE sequence with a fat saturation module (IR-FS-UTE). METHODS: All sequences were implemented on a 3T clinical scanner. The DIR-UTE Cones sequence combined a 3D UTE Cones sequence with two narrow-band adiabatic IR preparation pulses centered on water and fat spectrum frequencies, respectively. The 3D DIR-UTE Cones sequence was first applied to a phantom, then to the knees of four healthy volunteers and four patients diagnosed with osteoarthritis and compared to the IR-FS-UTE sequence. RESULTS: In both phantom and volunteer studies, the proposed DIR-UTE Cones sequence showed much higher contrast for OCJ imaging than the IR-FS-UTE sequence did. The 3D DIR-UTE Cones sequence showed a significantly higher contrast-to-noise ratio (CNR) between the OCJ and subchondral bone fat (BF) (mean, standard deviation (SD): 25.7 ± 2.3) and between the OCJ and superficial layers of cartilage (SC) (mean, SD: 22.2 ± 3.5) compared to the IR-FS-UTE sequence (mean, SD: 10.8 ± 2.5 and 16.3 ± 2.6, respectively). CONCLUSIONS: The 3D DIR-UTE Cones sequence is feasible for imaging of the OCJ region of the knee in vivo and produces both high resolution and high contrast.

In this paper the hydrodynamic performance of a barge-type floating foundation installed with four moonpools and a VAWT was investigated through model tests and theoretical calculations. The characteristics of wave-induced motion responses and tether tensions and the effects of turbine rotations were examined. Physical model tests were conducted in a wave tank using regular waves with the wave period ranging from 0.6 to 1.6 seconds and 0.01 or 0.02 meters in amplitude. A 2-MW-class VAWT was modelled with a scale ratio of 1/100 in the experiments. By varying the mass and the rotational speed of the turbine, gyroscopic moment effects were studied. In addition, numerical calculations based on the linear potential theory and Green function method were carried out to estimate motion responses and tether tensions. The present results indicate that the gyroscopic effect due to turbine rotations can be profound. It was found that the first-order motions of the floating system were substantially reduced by the gyroscopic effect, while the second-order motions and tether tensions may be significantly increased. Moreover, the viscous damping of water motions in moonpools was found not negligible. As a result, theoretical models based on linear potential theory should be used with care in hydrodynamic analysis with regard to the floating systems with VAWT rotations. In addition, the present in-house program code was validated against WAMIT through comparing hydrodynamic predictions of a floating foundation with four moonpools, with reasonable agreement.

To evaluate the efficacy and safety of superselective intra-arterial (IA) chemoradiotherapy with cisplatin and transcatheter arterial embolization (TAE) on advanced oral cancer, and to compare it with that of systemic chemoradiotherapy. This single-center retrospective study included 23 consecutive patients with locally advanced oral squamous cell carcinoma from November 2011 to November 2019. Of these, 15 received superselective IA cisplatin chemoradiotherapy with altered blood flow in the branches of the external carotid artery, and eight received systemic chemoradiotherapy. Medical charts were reviewed for the evaluation of patient data, drug toxicity, and antitumor efficacy. Local control rate for the superselective IA infusion group, who underwent 6–7 cycles was significantly higher than that of the systemic chemotherapy group (11/13, 85% vs 3/8, 38%; p = 0.04). Regional control, locoregional control, disease-free survival, and overall survival rates were not significantly different between the groups (p = 0.15–0.907). Acute toxicity rates of grade 3 or higher were not significantly different between the IA and IV chemotherapy groups (p = 0.221). Superselective IA chemoradiotherapy with cisplatin using altered blood flow in the branches of the external carotid artery with TAE may be useful for inoperable oral cancer.

In this study, we consider and evaluate the applicability of the FEMA’s formula which is one of the main simple formulas for calculating impact forces through the comparison with our proposed numerical simulation model. We investigated the situation of collision with a thin structure such as a pillar by numerical experiments based on the particle method, in particular, we focus on the case where the drifting speed is fast in targeting the quay of Shimizu Port, Shizuoka prefecture. We compared the results of numerical experiments obtained by detailed simulations with FEMA’s formula and evaluated the applicable range of FEMA s formula for huge vessels. As results, it was suggested that the overestimation was occurred with FEMA’s formula for large vessel using the inundation height and its velocity. FEMA’s formula calculates the impact force of large vessel on the safe side if the drifting vessel speed is used: the condition of added mass coefficient changes the results, but these indicate the safe side in this study. On the other hand, the results of safety sides are fluctuated depending on the height of the action point of force. Therefore, we confirmed that there is a need to examine the height of the impact point when using FEMA’s formula for large vessels.

Oscillating water column (OWC) type wave energy converters (WECs) have been researched and developed. OWC WECs are relatively friendly to maintain them in operation because all of mechanical units are set above a sea water surface. In addition, a feature of an OWC device is similar to an air dumper system. Thus, it should be possible not only to harvest wave energy but also to reduce motion of a floating system at the same time. As well as WEC system should be used with other ocean renewable energies as a combined system. This paper describes hydrodynamic characteristics of OWC devices and wave fields around them of multi-OWC devices equipped large floating structures. For this research, the linear potential theory based in-house programme code was applied to calculate hydrodynamic performance of OWC regions and elastic motion behaviours of the structures. Besides, calculation results were compared with some experimental results of characteristics of OWC devices on reference papers published. Then we proved validity of the calculation method. We have quantitatively summarized how much the reduction effect can be seen according to the aircushion placement and the number of aircushions on the floating body. the paper investigated arrangement of OWC devices on the floating structure with several variations. Using the prediction method, effects of arrangement of OWC devices on the performances are investigated.

This paper describes scale effects and influence of configurations of oscillating water column type wave energy converters from model tests and theoretical calculations. Many researches regarding wave energy converters (WECs) have been conducted. The behavior of an oscillating water column of an OWC type WEC is complicated because of including wave-air-turbine interaction, and thus several issues remain. One of the issues is that influence of difference in scale between small scale experimental models and full scale models is unclear. It is important to understand its characteristics accurately to improve design technologies for such as complicated systems. In this study, we carried out forced oscillation tests using multiple scales and shapes of OWC models in still water, and measured the pressure inside the air chamber and the internal mean water level with a multi-line wave probe. The experimental models used have a box like air chamber or manifold type air chamber, and which scales were 1/1, 1/2 and 1/4.The difference of the two air chambers is an orifice or a duct to be inlet-outlet of air. As a result, the difference in scale and configuration of the air chamber affected the characteristics of the air chamber. In addition, as a result of numerical calculation using the linear potential theory and comparison with experimental results, the experimental results could be reproduced by numerical calculation. Besides, we could discuss the effects and the influences of the air chamber basically.

The Great East Japan Earthquake that occurred in Japan in 2011, an innumerable number of buildings in the coastal part of the east side of Japan suffered catastrophic damage, and medical facilities in coastal areas have become dysfunctional because of the significant damage incurred due to the tsunami. And land routes are not passable, but there are records of support activities utilizing water areas such as sea and river networks being extremely effective in such disaster conditions. Therefore, as one of the effective methods of medical support in the affected area immediately after the disaster, a Floating Medical Support System (hereafter Medi-float) on big disaster that can be accessed from the water area was proposed. In the near future, the area along the Arakawa River is expected to be seriously damaged by the earthquake directly under the Tokyo metropolitan area. Therefore, by installing a Medi-float that can perform medical support activities from the water area to the land without being damaged by an earthquake, since Medi-float performs medical support activities in cooperation with medical facilities on land area, preventable death is reduced. In previous studies, a procedure to estimate the facilities scale and select a suitable site for Medi-float practically based on GIS data such as the number of collapsed buildings in the target area, distribution of injured people due to the earthquake were presented. However, even if Medi-float is installed in the target area, it cannot be denied that there is a shortage of medical facilities. In consideration of smooth transportation outside the region and cooperation with surrounding medical facilities, it is hoped that a concrete and realistic medical support system by Medi-float will be established. Therefore, in this study, in order to grasp the time it takes for the injured to be transported to the medical facility and the congestion status of the medical facility, the target area was divided into 250m meshes and a time-series simulation was performed. Specifically, the distribution of injured people during a disaster was calculated on a mesh basis from the number of buildings collapsed and the number of fires. And the transport time of the injured people is calculated from the distance between each mesh and the medical facility, the movement of the injured people in consideration of the congestion status of the medical facility was simulated, necessity of cooperation between medical facilities and wide area transportation was clarified, the effect of Medi-float, which is active in the disaster area, was also evaluated.

Intervertebral disc degeneration (IDD) is a major cause of chronic and debilitating back pain whose prevalence and severity make it a major health issue of substantial socioeconomic importance. The prevalence of chronic disabling back pain has tripled over the last 20 years [1] and the treatment of lower back pain in the United States is estimated to cost more than $100 billion per year. [2] Current treatment options are mostly palliative since disc tissue has little intrinsic repair capacity once a matrix synthesis/degradation imbalance occurs. Our bioengineered naturally secreted compositions have demonstrated the ability to decrease/remove protease and inflammatory cytokine activity and stimulate native cells to secrete new matrix production in vitro, and to maintain nucleus hydration and help to recover from the initial disc height loss in the semi-acute rabbit annular puncture model.

Two-dimensional (2D) analyses of intervertebral disc (IVD) height and foramen measurements following lateral lumbar interbody fusion (LLIF) have been reported. However, three-dimensional (3D) morphometric analysis of intervertebral structure using 3D computed tomography (3D CT) provides increased precision for measuring morphological changes. The purpose of this study was to evaluate 3D changes of lumbar IVD height and foramen diameter in degenerative lumbar disease patients following LLIF. Subject-based 3D CT lumbar models were created for 26 patients before and following LLIF. IVD height (whole and five anatomical zones) and foramen diameter (minimum and maximum) were measured based on the model using custom software. The sagittal placement of cages (SPC) and cross-sectional area of the thecal sac (CSA) were measured. Changes in these parameters by LLIF were quantified and statistically analysed. Following LLIF, disc height increased by an average of 2.9 mm (P

BackgroundThe degeneration of the intervertebral disc (IVD) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high proteoglycan-to-collagen ratio characteristic of a nucleus pulposus (NP)-like phenotype in vivo. At the moment, there is no medical treatment to reverse or even retard disc degeneration. The purpose of the present study was to determine if a low dose of short link N (sLN), a recently discovered fragment of the link N peptide, could behave in a manner similar to that of link N in restoring the proteoglycan content and proteoglycan-to-collagen ratio of the disc in a rabbit model of IVD degeneration, as an indication of its potential therapeutic benefit in reversing disc degeneration.MethodsAdolescent New Zealand white rabbits received an annular puncture with an 18-gauge needle into two noncontiguous discs to induce disc degeneration. Two weeks later, either saline (10μL) or sLN (25μg in 10μL saline) was injected into the center of the NP. The sLN concentration was empirically chosen at a lower molar concentration equivalent to half that of link N (100μg in 10 μL). The effect on radiographic, biochemical and histologic changes were evaluated.ResultsFollowing needle puncture, disc height decreased by about 25-30% within 2weeks and maintained this loss for the duration of the 12-week study; a single 25-μg sLN injection at 2weeks partially restored this loss in disc height. sLN injection led to an increase in glycosaminoglycans (GAG) content 12weeks post-injection in both the NP and annulus fibrosus (AF). There was a trend towards maintaining control disc collagen-content with sLN supplementation and the GAG-to-collagen ratio in the NP was increased when compared to the saline group.ConclusionsWhen administered to the degenerative disc in vivo, sLN injection leads to an increase in proteoglycan content and a trend towards maintaining control disc collagen content in both the NP and AF. This is similar to link N when it is administered to the degenerative disc. Thus, pharmacologically, sLN supplementation could be a novel therapeutic approach for treating disc degeneration.

Sarcoidosis is a multisystemic inflammatory disease of unknown origin characterized by the formation of noncaseating granulomas and accumulation of inflammatory cells. Sarcoidosis most commonly affects the lungs and lymphoid system. However, the liver can also be involved in 50%-65% of cases. On magnetic resonance imaging, sarcoidosis lesions usually present as hypointense lesions on all sequences. However, we present a rare case of nodular liver sarcoidosis presenting with T2 hyperintense lesions. In addition, while most cases of hepatic nodular sarcoidosis present with multiple small hepatic nodules, liver masses of our case are larger than usual. Moreover, this case suggested that when intact vascular structures penetrating liver nodular lesions are observed as in the current case, liver sarcoidosis can be included in a list of differential diagnosis. Keywords: Hepatic sarcoidosis, Atypical manifestations, CT, MRI