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Background: Idiopathic clubfoot is one of the most common and complex congenital deformities which are difficult to correct. Aims and Objectives: The present study was designed to assess the effectiveness and results of the Ponseti method’s early use in the treatment of idiopathic congenital talipes equinovarus (CTEV). Materials and Methods: Seventy-six feet in 50 patients of CTEV during the period of May 2019–May 2020 were studied. All the cases were treated by Ponseti technique. Children with idiopathic CTEV and age

Pulmonary hyalinising granuloma (PHG) is a benign lung disease. It is a rare disease of unknown aetiology. Less than 150 cases are reported. Its aetiology has not been established but the underlying cause is thought to be the deposition of an immune complex in lung parenchyma or autoimmune process. It usually presents as solitary or multiple lung nodules. PHG has a good prognosis. Solitary lesions are treated by resection and multiple lesions are treated with immunosuppressive drugs with variable responses. Here, we report a case of a 68-year-old female who presented with two episodes of haemoptysis. On investigation, chest computed tomography (CT) reveals multiple lung nodules on both sides, 18 F fluorodeoxyglucose (FDG) positron emission tomography and CT scan reveal mildly FDG avid and non-FDG avid subpleural and parenchymal nodular lesions of varying sizes with calcification noted scattered diffusely in both lung fields. Pathology findings are suggestive of fibrocollagenous tissue with tiny foci of epithelial cells arranged as papillae, cuboid cells with minimal atypia, mitosis, and necrosis not seen and no lymphoid tissue seen, suggestive of PHG.

Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-β-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing.

Metallization of polymers and fiber-reinforced polymer composites is gaining attention due to the widespread application of these components in various industries, such as wind energy, aerospace, and automotive industries. Cold spray is a promising new technique to achieve the metallization of polymer and fiber-reinforced polymer composites. This work investigates the deposition mechanisms of polymer-coated metallic particles on polymer-based substrates by finite element analyses. Impact mechanics of PEEK-coated nickel particles impacting PEEK and carbon fiber-reinforced PEEK substrates are modeled. Results show the prominence of mechanical interlocking of metallic particles in the substrate, which occurs due to their entrapment inside the substrate, caused by the high energy impact-induced welding of scraped PEEK coating. The PEEK coating acts as a cushioning component, effectively mitigating the impact energy of the metallic component. The scraped PEEK coating also accumulates on the upper half of the particle, forming a cap welded to the substrate and sealing the metallic particle inside. It is observed that the depth of the carbon fiber mat in the substrate affects the mechanism and the success of deposition.

Purpose During a pandemic, with businesses implementing social distancing protocols and work-from-home strategies, the use of continuous controls monitoring (CCM) may add value to the internal audit function. This study aims to examine the use of CCM technologies and the impact on the internal audit function during a pandemic. Design/methodology/approach This study adopted a case study approach for this study because it focuses on questions of “how” and “what.” Case studies provided an opportunity for an in-depth analysis of the phenomena being investigated. Semi-structured interviews were used to collect data. This study did not use sampling. Instead, multiple case studies were used for data collection. Findings Based on the findings, this study makes several contributions to the literature, for example, in health-care evidence suggests the pandemic has caused internal audit to focus on risk areas. Other industries, such as retail, have invested in CCM. However, in all cases, education and preparedness (or the lack thereof) appeared to significantly influence uptake of CCM. Organizations that made prior investments in CCM technologies experienced greater acceptance in the face of changing demands. Training in emerging technologies is a key competency in supporting audit operations in changing environments. Research limitations/implications As the study was conducted with a small sample of cases, findings cannot be extrapolated nor generalized beyond the case study organizations. Practical implications This study found that several factors limit adoption, exploitation and further development of CCM technologies, such as lack of top management support, acceptance of CCM technologies and suitable education and training of internal audit staff. Originality/value This study addresses the issue of the value that CCM offers organizations and whether it is a silver bullet that the internal audit profession needs, particularly when physical access to organizations may be restricted. The COVID-19 pandemic placed considerable focus on digital access. Better IT systems and more data will allow organizations to better support employees, inform strategic and financial decisions and engage stakeholders. During the recovery phase, leveraging investments in CCM technologies will contribute to internal audits’ ability to help clients to manage organizational risk.

Background: With the progressive development of blockchain technology, its potential influence on the accounting and auditing professions is of interest to academia and practitioners. As the technology gains acceptance in businesses such as banking, stock exchanges, insurance, law, government services, and e-voting, business leaders are beginning to recognise its potential to transform their organisations. Despite concerns about how this technology will marginalise the accounting and auditing profession, blockchain continues to lag behind in adoption and there is time for accountants and auditors to reflect on their current practice and update their knowledge and skills to maintain their relevance to the industry. Motivation: The literature has not fully examined the implications of distributed ledger technology and its implications for the accounting and auditing profession. The intent of this research note is to identify opportunities for research that are of significance to the application of distributed ledger technology to accounting and auditing. Research Question: To identify possibilities that exist in researching the adoption, implementation and application of a distributed ledger solution in the context of accounting and auditing. Framework: Based on the literature, the study proposes a framework for a blockchain model of a simplified triple-entry bookkeeping system using smart contracts to automate self-verification and replication of transactions in a public distributed ledger. Findings: Drawing on the framework the article develops a series of research questions that may significantly reduce barriers and challenges facing organizations that want to implement blockchain technology in their accounting systems. Contribution: Given the complex nature of blockchain, cross disciplinary research is proposed to bring together information technology, accounting, assurance, economics and psychology resulting in further understanding of the technology as it relates to, and influences the accounting and auditing profession. In doing so, the paper makes several contributions to the literature.

Gallbladder carcinoma (GBC) has a dismal prognosis even after curative resection. The objective of the study was to evaluate the effect of adjuvant chemotherapy in patients with GBC undergoing curative resection in a randomized control trial (RCT). A single-center open-labeled prospective RCT was done from January 2012 to June 2018. R0 curative resected GBC patients were randomized in 1:1 to either surveillance alone (control group) or adjuvant chemotherapy (gemcitabine and cisplatin (GemCis group)) for 6 cycles. The primary outcome was disease-free survival (DFS), and the secondary outcomes were overall survival (OS) and toxicity profile. On the evaluation of 362 patients with GBC, 50 patients were enrolled in each control or GemCis group. Per protocol (PP), it comprised 96 patients. The demographic and clinical profile was similar between the two groups except in the lower nodal stage where patients were higher in the control group (p = 0.01). Recurrences were similar between groups (control 44% vs GemCis 56%; p = 0.23). On the intention to treat (ITT), analyses of median DFS (not reached vs. 24 months, p = 0.14) and OS (not reached vs. 31 months, p = 0.10) were similar between groups. On PP, analyses of median DFS (not reached vs. 24 months, p = 0.16) and OS (not reached vs. 31 months, p = 0.09) were similar between groups. The common toxicity profile was hematological followed by gastrointestinal symptoms. Adjuvant GemCis therapy for 6 cycles does not improve DFS or OS than R0 surgery alone patients with GBC. NCT02778308 ( https://www.clinicaltrials.gov )

Objectives: It is difficult to capture the severity of synovial inflammation on imaging. Herein we hypothesize that diffusion tensor imaging (DTI) derived metrics may delineate the aggregation of the inflammatory cells and expression of inflammatory cytokines and dynamic contrast-enhanced (DCE) imaging may provide information regarding vascularity in the inflamed synovium. Patients and methods: Patients with knee arthritis (>3-months duration) underwent conventional (T2-weighted fast spin echo and spin echo T1-weighted images) as well as DTI and DCE MRI and thereafter arthroscopic guided synovial biopsy. DCE and DTI metrics were extracted from the masks of the segments of the inflamed synovium which enhanced on post-contrast T1-weighted MRI. These metrics were correlated with immunohistochemistry (IHC) parameters of inflammation on synovium. Statistical analysis: Pearson’s correlation was performed to study the relationship between DTI- and DCE-derived metrics, IHC parameters, and post-contrast signal intensity. Linear regression model was used to predict the values of IHC parameters using various DTI and DCE derived metrics as predictors. Results: There were 80 patients (52 male) with mean age 39.78 years and mean disease duration 19.82 months. Nineteen patients had tuberculosis and the rest had chronic undifferentiated monoarthritis (n = 31), undifferentiated spondyloarthropathy (n = 14), rheumatoid arthritis (n = 6), osteoarthritis (n = 4), reactive arthritis (n = 3), ankylosing spondylitis (n = 2), and juvenile idiopathic arthritis (n = 1). Fractional anisotropy (FA), a metric of DTI, had significant correlation with number of immune cells (r = 0.87, p < 0.01) infiltrating into the synovium and cytokines (IL-1β, r = 0.55, p < 0.01; TNF-α, r = 0.42, p < 0.01) in all patients and also in each group of patients and adhesion molecule expressed on these cells in all patients (CD54, r = 0.51, p < 0.01). DCE parameters significantly correlated with CD34 (blood flow, r = 0.78, p < 0.01; blood volume, r = 0.76, p < 0.01) in each group of patients, a marker of neo-angiogenesis. FA was the best predictor of infiltrating inflammatory cells, adhesion molecule and proinflammatory cytokines. Amongst the DCE parameters, blood volume, was best predictor of CD34. Conclusion: DTI and DCE metrics capture cellular and molecular markers of synovial inflammation in patients with chronic inflammatory arthritis.

Cold spray additive manufacturing is gaining popularity for polymers due to its low operating temperature and reduced manufacturing time. In the present study, the likeon- like impact of single thermoplastic polymer (polyether ether ketone, PEEK) particles on PEEK substrates is modeled to explore the effects of impact angle, initial particle temperature, and impact velocity on cohesion. The particle impact angle varies from 30o to 90o with 15o intervals for impact velocities ranging from 200 to 1000 m/s. Particle temperature in each case is varied from room temperature to the glass transition temperature of PEEK. Results obtained herein provide an insight into the energy balance and the temperature-velocity conditions likely to lead to bond formation. Modeling results demonstrate that the likelihood of bond formation increases with an increase in impact angle, particle temperature, and velocity, at the cost of bond strength.

Motivation: Fraud is a challenging problem. Its economic effects are clear – worse public services, less financially stable and profitable companies, charities deprived of resources needed for charitable purposes and diminished levels of disposable income of everyone. In every sector globally, fraud has an adverse impact on the quality of life. Fraud threatens the effective and efficient utilization of resources and hence is of great concern to industries, the whole community and academia. Research Question: Does political regime moderate the relationship between financial reporting regime and on fraud? Does the legal system moderate the relationship between financial reporting regime and on fraud? What is the impact of financial reporting regime, legal regime and political regime on fraud at national level? Idea: This study investigates how political, legal and financial reporting impacts on fraud at a country level and whether any triangular effects exist. Data: Country level data published by ACFE, World Fact book, Deloitte IAS Plus Report, IFAC Report and Economic Intelligence Unit Report on Democracy Index for 106 countries for the years 2010 to 2014 was used. Tools: To test study’s hypotheses and to determine the interactive effects of legal regime, political regime and financial reporting regime on fraud, a three-way ANOVA is used. To determine the impact of the independent variables on fraud, pooled regression analysis is used. Findings: The findings provide both theoretical and empirical evidence on the interaction effects of political, legal and financial reporting regimes on fraud. Political and legal regime has a significant interaction with financial reporting on fraud as posited by political accountability theory and legal theory. Even the main effects of each regime separately are statistically significant. Contribution: given the complex nature of frauds, the study is relevant to regulators, practising auditors, legal and political experts and politicians engaged in the debate on frauds and how to address this harmful act at a cross country level. When collusion exists between executive, legislative oversight in a full democratic regime is weakened, impacting the mechanism of fraud minimisation.

Cold spray deposition is a process in which bonding between solid microscale particles and a substrate occurs due to high energy impact. In this process, adhesion forms between the impacted particle and the substrate within a certain multi-parameter (material, temperature, particle size, etc.)-dependent impact velocity range. The present work analyzes the effects of particle diameter (for a range of 10-60 µm) on the adhesion of thermoplastic PEEK particles on PEEK substrates using a combined numerical-analytical approach. Our findings indicate that a maximum critical velocity (i.e., impact velocity required for a successful bond formation) of ~360 m/s is required for cold spraying of 10 µm PEEK particles at room temperature. The critical velocity decreases at higher temperatures and for particle diameters in the range of 10 to 40 µm. The predicted critical velocity is shown to increase again for particles with 60 µm diameter. For PEEK particles with diameters from 10 to 60 µm, the critical velocity window is determined to be in the range of 277-360 m/s. The velocity window decreases to 208-270 m/s if the spray temperature is increased to 150°C, i.e., slightly above the nominal glass transition temperature of PEEK.

Background As the global death toll from new coronavirus illness (COVID-19) rises, the scientific community and healthcare systems are under massive pressure to manage the outbreak and develop effective medical remedies. Meanwhile, desperation has pushed practitioners, scientists, and authorities to recommend and attempt medicines with little or no proof. Despite the lack of clear and unequivocal facts supporting its efficacy and safety, hydroxychloroquine-sulfate (HCQS) has recently received substantial public and political interest in treating and prophylaxis new infectious diseases COVID-19. Aim To analyze the impact of HCQS in COVID-19-positive patients admitted at tertiary level government-owned Jawaharlal Nehru Medical College and Hospital (JLNMCH, Bhagalpur) Bihar. Methods Two hundred two RT-PCR-positive COVID-19 patients were included in this research. The study participants were randomly distributed into the intervention category and control category, each consisting of 101 study subjects. Study participants in the intervention category were administered hydroxychloroquine in 200 mg tablets. The control category was given placebo tablets that looked similar to tablets of hydroxychloroquine and were given in the same pattern. Chest X-ray PA view, 12 lead ECG, baseline hemogram including a concentration of CD4 cells, ratio between the concentration of CD8 cells and CD4 cells and concentration of CD8 cells, the concentration of C-reactive protein, RT PCR test of samples obtained from the oropharyngeal region and nasopharyngeal region nasopharyngeal for verification COVID-19 were done. These measurements were carried out in both the control and intervention categories at baseline and at the moment of obtaining a negative RT-PCR report. Results The confirmed cases of COVID-19 was 52.9% in the intervention category and 53.4% in the control category at the end of the administration of drugs. Symptoms related to COVID-19 were observed in 11.6% of subjects in the intervention category and 13.5% in the control category. Other new symptoms were observed in 16.8% of subjects in the intervention category and 14.5% of study subjects in the control category. One death was reported in the control category. Emergency hospitalization was required for one subject in the intervention category, while two subjects in the control category required emergency hospitalization. 12.4 days was the mean duration of recovery in the intervention category, while 13.6 days were the mean duration of recovery in the control category. The recovery duration and COVID-related symptoms were lesser in the intervention category than in the control category; however, the variation between the two categories was statistically non-significant (p˃0.01). Conclusion According to this research, no statistically significant difference was noticed in COVID-19 incidence between the control category and intervention category, showing that hydroxychloroquine sulfate cannot be utilized as the main curative agent in the treatment of COVID-19. However, there was a reduction in recovery days and symptoms related to COVID-19 in study subjects administered with HCQS.

Introduction:Oesophageal carcinoma is one of the fatal cancers mainly because of its rapid spread and poor prognosis. Treatment modalities involves a multimodality approach, including surgery, radiation therapy and chemotherapy. Radiation therapy includes brachytherapy in the form of intraluminal radiation therapy. Brachytherapy permits delivery of high tumouricidal doses to superficial cancerous growth of the oesophagus while delivering much lower doses to the surrounding tissue. It is mostly given in combination with external beam radiation in patients with poor performance scores not likely to tolerate an aggressive chemoradiation regimen or as a boost to concurrent chemoradiotherapy. It is very effective in terms of local tumour control as well as in relieving symptoms in advanced/recurrent disease. Intraoperative brachytherapy and seed brachytherapy have also been tried to address the nodal disease.Methods:We undertook a review of the available literature and techniques developed in the past three decades to emphasise the role of brachytherapy in curative or palliative settings in the treatment of oesophageal carcinoma.Conclusion:Oesophageal brachytherapy will remain a tangible treatment of oesophageal cancer, although it is less commonly used due to high expertise requirement, lack of established evidence, risk of life-threatening complications and lack of interest in brachytherapy. It offers quick and useful palliation for a prolonged period, along with good quality of life and superior dosimetry. Use of novel applicators may allow dose escalation and lower toxicity. Seed brachytherapy is also emerging as a promising option in nodal recurrences.

Background: The high permeability of Distributed Generation (DG) and the development of DC load represented by electric vehicle Battery Swapping Station (BSS) pose new challenges to the reliable and economic operation of DC distribution system. Methods: In order to improve the wind and solar absorption rate and the reliable operation of DC distribution network and coordinate the interests and demands of BSS and DC distribution company, the upper level takes the abandonment rate and the minimum variance of BSS charging and discharging net load as two objective functions, and the lower level takes the minimum operation cost of DC distribution network and BSS as the objective function. Secondly, this paper proposes a method that combines Genetic Algorithm (GA) with Wind-Driven Optimization algorithm (WDO). CPLEX and hybrid GA-WDO are used to solve the upper and lower models, respectively. Results: Finally, an example shows that the proposed optimization model can reduce the operation cost of DC distribution network with BSS and improve the utilization rate of wind and light, which shows the rationality and effectiveness of the optimization model. Conclusion: In this paper, considering the randomness and uncertainty of wind power generation and photovoltaic power generation, this paper establishes the upper objective function with the minimum abandonment rate and load variance and the lower objective function with the minimum operation cost of DC distribution network and BSS operators.

Microorganisms that are capable of live and adapt in hostile habitats of different environmental factors such as extremes temperature, salinity, nutrient availability and pressure are known as extremophiles. Exposure to xenobiotic compounds is global concern influencing the world population as a health hazard. Hence their removal is warranted using biological means that is very sustainable, potentially cost-effective and eco-friendly. Due to adaptation in extreme environments and unique defense mechanisms, they are receiving more attention for the bioremediation of the xenobiotic compounds. They possess robust enzymatic and biocatalytic systems that make them suitable for the effective removal of pollutants from the contaminated environment. Additionally, the extremophiles act as microfactories having specific genetic and biotechnological potential for the production of biomolecules. This mini review will provide an overview of microbial degradation metabolic pathways for bioremediation along with the molecular and physiological properties of diverse extremophiles from variety of habitats. Furthermore, the factors affecting the bioremediation process is also summarized.

Research Question: Do modern ERP systems record sufficient information to allow retrospective monitoring of accounts payable transactions? Can Benford’s Law be applied to these transactions to detect potential fraud in accounting data? Motivation: Modern ERP systems are capable of recording several thousands of transactions daily. This makes it difficult to find a few instances of anomalous activities among legitimate transactions. As organizations continue to become more complex and demand more integrated business processes, automated analytics may provide auditors and fraud examiners some degree of assurance on continuous information simultaneously with, or shortly after disclosure of information. Idea: In this study we develop a proof of concept prototype to monitor invoice transactions and identify those that violate Benford’s law. The prototype exploits audit trails in enterprise systems. Data: Data was obtained from the SAP ERP systems of two large organizations. Organization 1, a government department, provided a one month sample of accounting transaction data. Organization 2, a global manufacturing company, provided a six month sample of their transaction data. Tools: Verification and validation was achieved by obtaining independent reviews from an expert and a panel of auditing practitioners. Their feedback was sought using a survey instrument where they rated various aspects of the prototype software. Findings: A key aim was to demonstrate the feasibility of implementing Benford’s analysis in continuous monitoring applications by exploiting audit trails in ERP systems. The concept was demonstrated by designing prototype software. We found that Benford’s analysis, is a useful tool for identifying suspicious transactions. These transactions may contain possible errors, potential fraud or other irregularities. Contribution: An important contribution of the study is that the entire population of transactions for a specified time period are analyzed. This approach is in contrast with the traditional or manual audit approach which is limited because it reviews only a small percentage of a large population of transactions. The prototype demonstrates the application of technology and data analytics to process transaction data from a SAP ERP system in a near real-time basis. This represents the next step in the evolution of the financial audit from manual to automated methods.

Hilbert Space has wide usefulness in signal processing research. It is pitched at a graduate student level, but relies only on undergraduate background material. The needs and concerns of the researchers In engineering differ from those of the pure science. It is difficult to put the finger on what distinguishes the engineering approach that we have taken. In the end, if a potential use emerges from any result, however abstract, then an engineer would tend to attach greater value to that result. This may serve to distinguish the emphasis given by a mathematician who may be interested in the proof of a fundamental concept that links deeply with other areas of mathematics or is a part of a long-standing human intellectual endeavor not that engineering, in comparison, concerns less intellectual pursuits. The theory of Hilbert spaces was initiated by David Hilbert (1862-1943), in the early of twentieth century in the context of the study of "Integral equations". Integral equations are a natural complement to differential equations and arise, for example, in the study of existence and uniqueness of function which are solution of partial differential equations such as wave equation. Convolution and Fourier transform equation also belongs to this class. Geometric intuition plays an important role in many aspects of Hilbert space theory. Exact analogs of the Pythagorean theorem and parallelogram law hold in Hilbert space. At a deeper level, perpendicular projection onto a subspace that is the analog of "dropping the altitude" of a triangle plays a significant role in optimization problem and other aspects of the theory. An element of Hilbert space can be uniquely specified by its co-ordinates with respect to a set of coordinate axes that is an orthonormal basis, in analogy with Cartesian coordinates in the plane. When that set of axes is countably infinite, this means that the Hilbert space can also usefully be thought in terms of infinite sequences that are square summable. Linear operators on Hilbert space are ply transformations that stretch the space by different factors in mutually perpendicular directions in a sense that is made precise by the study of their spectral theory. In brief Hilbert spaces are the means by which the ordinary experience of Euclidean concepts can be extended meaningfully into idealized constructions of more complex abstract mathematics. However, in brief, the usual application demand for Hilbert spaces are integral and differential equations, generalized functions and partial differential equations, quantum mechanics, orthogonal polynomials and functions, optimization and approximation theory. In signal processing which is the main objective of the present thesis and engineering. Wavelets and optimization problem that has been dealt in the present thesis, optimal control, filtering and equalization, signal processing on 2- sphere, Shannon information theory, communication theory, linear and non-linear theory and many more is application domain of the Hilbert space.

Microorganisms are an important component of the ecosystem and have an enormous impact on human lives. Moreover, microorganisms are considered to have desirable effects on other co-existing species in a variety of habitats, such as agriculture and industries. In this way, they also have enormous environmental applications. Hence, collections of microorganisms with specific traits are a crucial step in developing new technologies to harness the microbial potential. Microbial culture collections (MCCs) are a repository for the preservation of a large variety of microbial species distributed throughout the world. In this context, culture collections (CCs) and microbial biological resource centres (mBRCs) are vital for the safeguarding and circulation of biological resources, as well as for the progress of the life sciences. Ex situ conservation of microorganisms tagged with specific traits in the collections is the crucial step in developing new technologies to harness their potential. Type strains are mainly used in taxonomic study, whereas reference strains are used for agricultural, biotechnological, pharmaceutical research and commercial work. Despite the tremendous potential in microbiological research, little effort has been made in the true sense to harness the potential of conserved microorganisms. This review highlights (1) the importance of available global microbial collections for man and (2) the use of these resources in different research and applications in agriculture, biotechnology, and industry. In addition, an extensive literature survey was carried out on preserved microorganisms from different collection centres using the Web of Science (WoS) and SCOPUS. This review also emphasizes knowledge gaps and future perspectives. Finally, this study provides a critical analysis of the current and future roles of microorganisms available in culture collections for different sustainable agricultural and industrial applications. This work highlights target-specific potential microbial strains that have multiple important metabolic and genetic traits for future research and use.

Understanding the hierarchy in the mechanical behavior of heterogeneous materials requires a systematic characterization of the material response at different length scales, as well as the nature and characteristics of the transitional scales. Characterization of such transitional length scales has been carried out in the past by analytical models that calculate and compare stiffness values at micro and macro scales. The convergence of the material stiffness at the two scales has been used as the criterion for quantification of the so-called transitional length scales. These stiffness calculation approaches are based on the idea of local strain and stress distributions obtained from complex finite element models. Recent advancements in full-field experimental strain measurements have made it possible to identify the transitional length scales in fiber composites based on pure experimental measurements without the requirement of local stress analysis. In this work, we study the validity of such ‘strain-based’ approaches that are used to identify the RVE size in unidirectional fiber composites. Our modeling platform replicates the realistic conditions present in experimental measurements through the randomization of fiber locations and volume fraction within an epoxy matrix.

Background: Median nerve is generally formed in axilla, as one of the branch of brachial plexus. It is formed by the union of medial and lateral roots which are the branches of me­dial and lateral cord respectively. The knowledge of origin, course and area of distribution of median nerve is important for the anatomist, the neurologist and also for correction of traumatic injuries that are related to brachial plexus. The main objective of this study is to observe different variations in median nerve formation in cadavers. Methods: A descriptive cross-sectional study was conducted in 25 formalin fixed adult human ca­davers in the Department of Anatomy, KIST Medical College and Teaching Hospital, Lalitpur Ethical approval was taken. Altogether, 50 specimens were enrolled in the study by convenient sampling method. The calculation was done using Statistical Package for Social Sciences version 20 (SPSS). Results: In this study the formation of median nerve was observed to be normal in 78% of the cases. In 20% cases three roots were forming the median nerve and in 2% cases four roots were present. Among these variations in 18% cases the additional roots were observed to be given by the lateral cord of the brachial plexus. Conclusions: This study concludes that most of the median nerve forms in axilla by the union of two roots with few variations.