Search

This work focuses on active galactic nuclei (AGNs), and the relation between the sizes of the hot dust continuum and the broad-line region (BLR). We find that the continuum size measured using optical/near-infrared interferometry (OI) is roughly twice that measured by reverberation mapping (RM). Both OI and RM continuum sizes show a tight relation with the H$\beta$ BLR size with only an intrinsic scatter of 0.25 dex. The masses of supermassive black holes (BHs) can hence be simply derived from a dust size in combination with a broad line width and virial factor. Since the primary uncertainty of these BH masses comes from the virial factor, the accuracy of the continuum-based BH masses is close to those based on the RM measurement of the broad emission line. Moreover, the necessary continuum measurements can be obtained on a much shorter timescale than those required monitoring for RM, and are also more time efficient than those needed to resolve the BLR with OI. The primary goal of this work is to demonstrate measuring the BH mass based on the dust continuum size with our first calibration of the $R_\mathrm{BLR}$-$R_\mathrm{d}$ relation. The current limitation and caveats are discussed in detail. Future GRAVITY observations are expected to improve the continuum-based method and have the potential to measure BH masses for a large sample of AGNs in the low-redshift Universe., Comment: Accepted for publication in A&A; 11 pages, 5 figures, 3 tables

Objective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist € s diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations.

Blue, red and yellow chitin nanofibers were obtained using reactive dyes. Since the chitin nanofibers and the dye are covalently bonded, they are resistant to hot water and detergents. Since the dyed chitin nanofibers can be mixed at an arbitrary ratio, purple, orange, and green nanofibers corresponding to the mixed colors could be obtained. The dyed chitin nanofibers were evaluated by the reflection spectrum and the color space (L*a*b*). From the viewpoint of reaction yield and color properties, the appropriate ratio of the reactive dye to chitin was 5% at the maximum. The morphology of chitin nanofibers was maintained even after the introduction of the reactive dye. A resin reinforced with dyed chitin nanofibers was prepared. By combining with nanofibers, it is possible to give color and improve mechanical strength to resin while maintaining the transparency of the resin to some extent.

Miyako Kishimoto1,21Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan; 2Department of Internal Medicine, Sanno Hospital, Tokyo, JapanPurpose: Diabetes is a multifactorial disease, and interprofessional teamwork is essential for its treatment. For successful interprofessional teamwork, individual medical professionals need to have certain skills, experience, and mutual understanding of the role of different professions. However, there are few opportunities to educate medical professionals to meet these demands. To resolve this problem, educational seminars about diabetes were conducted by and for medical professionals, and their effects were assessed using a questionnaire survey.Participants and methods: Medical professionals, including a dietician, a physiotherapist, a pharmacist, a clinical laboratory technician, and a doctor, provided 10 lectures, approximately 50 mins each, for medical professionals about their specialized skills in diabetes care. Nurses who were certified diabetes educators in Japan planned and organized the seminars. In every seminar, participants were asked to complete a questionnaire regarding their profession, motivation to attend the seminar, general comments about the seminar, expectations regarding future seminars, and effects of the seminar on their daily work or attitude toward patients.Results: Among the 367 participants, 332 completed the questionnaire (respondents). The results revealed that by attending the seminars, some respondents strongly realized their lack of knowledge, some were inspired and encouraged to study more about diabetes, and some could understand other professions’ work in diabetes care better than before. Over 70% of respondents reported that attending the seminar had changed their daily work or attitude toward patients; the remainder, however, felt unchanged for reasons such as their own lack of experience and ability, and the few chances to aid patients with diabetes.Conclusion: Educational diabetes seminars by and for medical professionals were implemented. The survey of the effects of the seminar has provided further insights into the needs and current situation of education for medical professionals.Keywords: diabetes, educational seminar, interprofessional teamwork, questionnaire

The GRAVITY instrument was primarily conceived for imaging and astrometry of the Galactic centre. However, its sensitivity and astrometric capabilities have also enabled interferometry to reach a new domain of astrophysics: exoplanetology. In March 2019, the GRAVITY collaboration published the first spectrum and astrometry of an exoplanet obtained by optical interferometry. In this article, we show how this observation is paving the way to even more exciting discoveries — finding new planets, and characterising their atmospheres., Published in The Messenger vol. 178, pp. 47-49, December 2019.

The main goal of an interferometer is to probe the physics of astronomical objects at the highest possible angular resolution. The most intuitive way of doing this is by reconstructing images from the interferometric data. GRAVITY at the Very Large Telescope Interferometer (VLTI) has proven to be a fantastic instrument in this endeavour. In this article, we describe the reconstruction of the wind-wind collision cavity of the massive binary η Car with GRAVITY across two spectral lines: HeI and Brγ., Published in The Messenger vol. 178, pp. 31-33, December 2019.

International audience; Diffraction fundamentally limits our ability to image and characterize exoplanets. Interferometry offers some advantages in exoplanet detection and characterization and we explore in this white paper some of the potential scientific breakthroughs possible.

The angular resolution of the Very Large Telescope Interferometer (VLTI) and the excellent sensitivity of GRAVITY have led to the first detection of spatially resolved kinematics of high velocity atomic gas near an accreting super- massive black hole, revealing rotation on sub-parsec scales in the quasar 3C 273 at a distance of 550 Mpc. The observations can be explained as the result of circular orbits in a thick disc configuration around a 300 million solar mass black hole. Within an ongoing Large Programme, this capability will be used to study the kinematics of atomic gas and its relation to hot dust in a sample of quasars and Seyfert galaxies. We will measure a new radius-luminosity relation from spatially resolved data and test the current methods used to measure black hole mass in large surveys., Published in The Messenger vol. 178, pp. 20-24, December 2019.

GRAVITY observations reveal that most massive stars in the Orion Trapezium cluster live in multiple systems. Our deep, milliarcsecond-resolution interferometry fills the gap at 1–100 astronomical units (au), which is not accessible to traditional imaging and spectroscopy, but is crucial to uncovering the mystery of high-mass star formation.The new observations find a significantly higher companion fraction than earlier studies of mostly OB associations. The observed distribution of mass ratios declines steeply with mass and follows a Salpeter power-law initial mass function. The observations therefore exclude stellar mergers as the dominant formation mechanism for massive stars in Orion., Published in The Messenger vol. 178, pp. 36-38, December 2019.

Near-infrared interferometry gives us the opportunity to spatially resolve the circumstellar environment of young stars at sub-astronomical-unit (au) scales, which a standalone telescope could not reach. In particular, the sensitivity of GRAVITY on the VLTI allows us to spatially resolve the CO overtone emission at 2.3 microns. In this article, we present a new method of using the model of the CO spectrum to reconstruct the differential phase signal and extract the geometry and size of the emitting region., Published in The Messenger vol. 178, pp. 40-42, December 2019.

The superb resolution of the Very Large Telescope Interferometer (VLTI) and the unrivalled sensitivity of GRAVITY have allowed us to reconstruct the first detailed image of the dust sublimation region in an active galaxy. In the nearby archetypal Seyfert 2 galaxy NGC 1068, the 2 µm continuum emission traces a highly inclined thin ring-like structure with a radius of 0.24 pc. The observed morphology challenges the picture of a geometrically and optically thick torus., Published in The Messenger vol. 178, pp. 24-26, December 2019.

More than 4000 exoplanets are known to date in systems that differ greatly from our Solar System. In particular, inner exoplanets tend to follow orbits around their parent star that are much more compact than that of Earth. These systems are also extremely diverse, covering a range of intrinsic properties. Studying the main physi- cal processes at play in the innermost regions of the protoplanetary discs is crucial to understanding how these planets form and migrate so close to their host. With GRAVITY, we focused on the study of near-infrared emission of a sample of young intermediate- mass stars, the Herbig Ae/Be stars., Published in The Messenger vol. 178, pp. 38-40, December 2019.

International audience; In this white paper, we explore how higher angular resolution beyond ALMA and 8m-class telescopes can extend our understanding of the key stages of planet formation, to resolve accreting circumplanetary disks themselves, and to watch planets forming in situ for the nearest star-forming regions.

A Li-like Al soft x-ray laser oscillation (15.47 nm) by means of recombination plasma scheme was investigated to enhance the gain coefficent of lasing medium. In this study, we employed a Nd:YAG laser pulse composed of 8-pulse train, in which each pulse width was 400 ps and its interpulse time was 400 ps. The laser beam was tightly line-focused into 50 μm in height and 12 mm in length on Al slab target by using prism lens array. The created cylindrical plasma showed that with increasing plasma length the lasing intensity at 15.47 nm increased expoentially up to 3.5 mm. For the laser energy of 3 J, the gain coefficient was 8.3 cm−1. Above 3.5 mm in length, the signals seemed to increase linearly, indicating that the lasing action reached the saturation regime.

The broadening of atomic emission lines by high-velocity motion of gas near accreting supermassive black holes is an observational hallmark of quasars. Observations of broad emission lines could potentially constrain the mechanism for transporting gas inwards through accretion disks or outwards through winds. The size of this broad-line region has been estimated by measuring the light travel time delay between the variable nuclear continuum and the emission lines - a method known as reverberation mapping. In some models the emission lines arise from a continuous outflow, whereas in others they are produced by orbiting gas clouds. Directly imaging such regions has not hitherto been possible because of their small angular sizes (< 0.1 milli-arcseconds). Here we report a spatial offset (with a spatial resolution of ten micro-arcseconds or about 0.03 parsecs for a distance of 550 million parsecs) between the red and blue photo-centres of the broad Paschen-{\alpha} line of the quasar 3C 273 perpendicular to the direction of its radio jet. This spatial offset corresponds to a gradient in the velocity of the gas and thus implies that the gas is orbiting the central supermassive black hole. The data are well fitted by a broad-line-region model of a thick disk of gravitationally bound material orbiting a black hole of 300 million solar masses. We infer a disk radius of 150 light days; a radius of 100-400 light days was found previously using reverberation mapping. The rotation axis of the disk aligns in inclination and position angle with the radio jet. Our results support the methods that are often used to estimate the masses of accreting supermassive black holes and to study their evolution over cosmic time., Comment: 19 pages including methods, Nature, in press. Press embargo until 1800 London time / 1300 US Eastern Nov 28

Optical long-baseline interferometry is a unique and powerful technique for astronomical research. Since 2004, optical interferometers have produced an increasing number of scientific papers covering various fields of astrophysics. As current interferometric facilities are reaching their maturity, we take the opportunity in this paper to summarize the conclusions of a few key meetings, workshops, and conferences dedicated to interferometry. We present the most persistent recommendations related to science cases and discuss some key technological developments required to address them. In the era of extremely large telescopes, optical long-baseline interferometers will remain crucial to probe the smallest spatial scales and make breakthrough discoveries., 11 pages, 1 figure, accepted for publication in Experimental Astronomy

A series of full-Heusler alloys, $\rm Fe_2V_{1-x}W_xAl$, $0 \leq x \leq 0.2$, was prepared, characterized and relevant physical properties to account for the thermoelectric performance were studied in a wide temperature range. Additionally, off-stoichiometric samples with similar compositions have been included, and a 10~\% improvement of the thermoelectric figure of merit was obtained. The V/W substitution causes i) a change of the main carrier type, from holes to electrons as evidenced from Seebeck and Hall measurements and ii) a substantial reduction of the lattice thermal conductivity due to a creation of lattice disorder by means of a distinct different mass and metallic radius upon the V/W substitution. Moreover $ZT$ values above 0.2 have been obtained. A microscopic understanding of the experimental data observed is revealed from ab-initio calculations of the electronic and phononic structure., Comment: 10pages, 12figures

Ryo Rokutanda, Mitsumasa Kishimoto, Masato Okada Immuno-Rheumatology Center, St Luke’s International Hospital, Tokyo, Japan Abstract: Behçet’s disease is a multi-organ disorder that is more common in countries around the Silk Road, and manifests as mucosal ulcers and skin lesions, and with ocular involvement. As a systemic disease, it can also involve gastrointestinal organs and the central nervous or cardiovascular systems. Although the etiology of Behçet's disease is not clearly identified, the pathogenesis of the disease is most commonly hypothesized as a profound inflammatory response triggered by an infectious agent in a genetically susceptible host. As there are no single specific manifestations or specific diagnostic tests, various diagnostic criteria have been proposed around the world, and, among them, the International Study Group criteria have been most commonly used. As the clinical expression of Behçet's disease is heterogeneous, the treatment should be individualized based on involved organs, severity of the disease, and patient's background. The choice of therapeutic agents is limited by lack of clinical trials and is based largely on case reports, case series, and several open-label clinical trials. Corticosteroids, colchicine, and traditional immunosuppressive agents, including azathioprine and cyclosporine, have been used for the treatment of Behçet’s disease. Recently, tumor necrosis factor (TNF) inhibitors have become available for several rheumatic diseases, and considerable published data suggest that TNF inhibitors represent an important therapeutic advance for patients with severe and resistant disease, as well as for those with contraindications or intolerance to these treatments. Keywords: Behçet’s disease, therapeutic agents, etiology, diagnosis

Background: The efficacy and safety of ixekizumab were evaluated in patients with active PsA. Methods: Patients (N=417) were randomized to ixekizumab 80mg once every 4 (IXEQ4W) or 2 (IXEQ2W) weeks (160mg starting dose included), 40mg adalimumab, or placebo during the double-blind treatment period[for full text, please go to the a.m. URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Miyako Kishimoto,1,2 Mitsuhiko Noda2,3 1Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan; 2Diabetes and Metabolism Information Center, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan; 3Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Background: Diabetes is a multifactorial disease and its nature means that interprofessional teamwork is essential for its treatment. However, in general, interprofessional teamwork has certain problems that impede its function. To clarify these problems in relation to diabetes care, a questionnaire survey was conducted. Methods: The participants who were involved in diabetes-related educational seminars, and medical personnel who were engaged in diabetes care from the National Center for Global Health and Medicine, were asked to complete the questionnaire about perceptions of, and satisfaction with, interprofessional teamwork across multiple health care providers, who were actually involved in diabetes care. Results: From 456 people who were asked to take the questionnaire, 275 people answered. The percentages of the respondents according to profession who considered multidisciplinary teamwork sufficient were as follows: physicians, 20.5%; nurses, 12.7%; registered dietitians, 29.6%; pharmacists, 21.9%; physiotherapists, 18.2%; and clinical laboratory technicians 15.4%. Insufficient interprofessional communication and inconsistency in motivation levels among staff were frequently cited as causes of insufficient teamwork. All professions considered interprofessional meetings or conferences necessary and essential for teamwork. Conclusion: The survey revealed that interprofessional teamwork in diabetes care is currently insufficient. Continuous efforts to change each profession's perceptions about interprofessional teamwork and efforts to improve the quality of interprofessional meetings are necessary. Keywords: diabetes, interprofessional, questionnaire survey, communication

Taro Shimizu,1 Yusuke Tsugawa,2,3 Yusuke Tanoue,4 Ryota Konishi,5 Yuji Nishizaki,6 Mitsumasa Kishimoto,7 Toshiaki Shiojiri,8 Yasuharu Tokuda9 1Hospitalist Division, Department of Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan; 2Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; 3Center for Clinical Epidemiology, St Luke's Life Science Institute, 4Department of Vascular and Oncological Surgery, Hospital of Tokyo University, 5Department of General Internal Medicine, Kanto Rousai Hospital, 6Department of Cardiology, Juntendo University School of Medicine, 7Division of Rheumatology, St Luke's International Hospital, Tokyo, Japan; 8Asahi Chuo Hospital, Chiba, Japan; 9Department of Medicine, Tsukuba University Mito Kyodo General Hospital, Mito City, Ibaraki, Japan Background: It is believed that the type of educational environment in teaching hospitals may affect the performance of medical knowledge base among residents, but this has not yet been proven. Objective: We aimed to investigate the association between the hospital educational environment and the performance of the medical knowledge base among resident physicians in Japanese teaching hospitals. Methods: To assess the knowledge base of medicine, we conducted the General Medicine In-Training Examination (GM-ITE) for second-year residents in the last month of their residency. The items of the exam were developed based on the outcomes designated by the Japanese Ministry of Health, Labor, and Welfare. The educational environment was evaluated using the Postgraduate Hospital Educational Environment Measure (PHEEM) score, which was assessed by a mailed survey 2 years prior to the exam. A mixed-effects linear regression model was employed for the analysis of variables associated with a higher score. Results: Twenty-one teaching hospitals participated in the study and a total of 206 residents (67 women) participated and completed the exam. There were no residents who declined to participate in the exam. The mean GM-ITE score was 58 (standard deviation 8.4). The mixed-effects linear regression analysis showed that a higher PHEEM score was associated with a higher GM-ITE score (P = 0.02). Having a department of general medicine, and hospital location in a provincial community (versus an urban setting), were also shown to have a significant relationship with the higher score (P = 0.03, and P = 0.02, respectively). Conclusion: We found that the performance of the medical knowledge base of resident physicians was significantly associated with the educational environment of their hospitals. Improvement of the educational environment in teaching hospitals might be crucial for enhancing the performance of resident physicians in Japan. Keywords: outcome-based education, postgraduate medical education, educational environment, general medicine, provincial hospital

Miyako KishimotoDepartment of Diabetes and Metabolic Medicine, Center Hospital, Tokyo, Japan; Diabetes and Metabolism Information Center, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, JapanAbstract: Dipeptidyl peptidase-4 (DPP-4) inhibitors have recently emerged as a new class of antidiabetic that show favorable results in improving glycemic control with a minimal risk of hypoglycemia and weight gain. Teneligliptin, a novel DPP-4 inhibitor, exhibits a unique structure characterized by five consecutive rings, which produce a potent and long-lasting effect. Teneligliptin is currently used in cases showing insufficient improvement in glycemic control even after diet control and exercise or a combination of diet control, exercise, and sulfonylurea- or thiazolidine-class drugs. In adults, teneligliptin is orally administered at a dosage of 20 mg once daily, which can be increased up to 40 mg per day. Because the metabolites of this drug are eliminated via renal and hepatic excretion, no dose adjustment is necessary in patients with renal impairment. The safety profile of teneligliptin is similar to those of other available DPP-4 inhibitors. However, caution needs to be exercised when administering teneligliptin to patients who are prone to QT prolongation. One study has reported that the postprandial blood glucose-lowering effects of teneligliptin administered prior to breakfast were sustained throughout the day, and the effects observed after dinner were similar to those observed after breakfast or lunch. Thus, although clinical data for this new drug are limited, this drug shows promise in stabilizing glycemic fluctuations throughout the day and consequently suppressing the progression of diabetic complications. However, continued evaluation in long-term studies and clinical trials is required to evaluate the efficacy and safety of the drug as well as to identify additional indications for its clinical use.Keywords: teneligliptin, DPP-4 inhibitor, diabetes

Systemic Amyloid A Amyloidosis in a Dog with Sub-acute Time Course after Anesthesia An 8-year-old female beagle used for investigation of diagnostic imaging rapidly became ill without premonitory symptoms the day after undergoing anesthesia and died about 2 months later. Systemic amyloidosis was found by necropsy, and severe amyloid deposition was observed in the pancreas, kidney and spleen. Immunohistochemically, almost all amyloid depositions comprised amyloid A. Other findings included thrombi in the pulmonary artery and aorta and plasma cell infiltration in multiple organs, including the kidneys. Amyloid A amyloidosis is the most common type of amyloidosis in animals and occurs in association with chronic inflammation and neoplasia. However, the sub-acute course in the present case is rare and suggests an association between anesthesia and thrombi without clear background lesions.

The UX Ori type variables (named after the prototype of their class) are intermediate-mass pre-main sequence objects. One of the most likely causes of their variability is the obscuration of the central star by orbiting dust clouds. We investigate the structure of the circumstellar environment of the UX~Ori star V1026 Sco (HD 142666) and test whether the disk inclination is large enough to explain the UX Ori variability. We observed the object in the low-resolution mode of the near-infrared interferometric VLTI/AMBER instrument and derived H- and K-band visibilities and closure phases. We modeled our AMBER observations, published Keck Interferometer observations, archival MIDI/VLTI visibilities, and the spectral energy distribution using geometric and temperature-gradient models. Employing a geometric inclined-ring disk model, we find a ring radius of 0.15 +- 0.06 AU in the H band and 0.18 +- 0.06 AU in the K band. The best-fit temperature-gradient model consists of a star and two concentric, ring-shaped disks. The inner disk has a temperature of 1257^{+133}_{-53} K at the inner rim and extends from 0.19 +- 0.01 AU to 0.23 +- 0.02 AU. The outer disk begins at 1.35^{+0.19}_{-0.20} AU and has an inner temperature of 334^{+35}_{-17} K. The derived inclination of 48.6^{+2.9}_{-3.6}deg approximately agrees with the inclination derived with the geometric model (49 +- 5deg in the K band and 50 +- 11deg in the H band). The position angle of the fitted geometric and temperature-gradient models are 163 +- 9deg (K band; 179 +- 17deg in the H band) and 169.3^{+4.2}_{-6.7}deg, respectively. The narrow width of the inner ring-shaped model disk and the disk gap might be an indication for a puffed-up inner rim shadowing outer parts of the disk. The intermediate inclination of ~50deg is consistent with models of UX Ori objects where dust clouds in the inclined disk obscure the central star.

Purpose: In cataract surgery with Venturi pumps, pressure and flow volume cannot be set separately. We studied a way to control flow volume more effectively. Methods: To decrease the flow volume of a venturi pump without reducing the aspiration pressure, it is necessary to adjust the tube diameter[for full text, please go to the a.m. URL], 27. Internationaler Kongress der Deutschen Ophthalmochirurgen

Accepted: 2013-04-23, 資料番号: SA1004530000

Propose: The power that must be known for cavitation is concealed. We examined whether we could not do something about this cavitation. Methods: We inspected the power of cavitation using hard to remove oily ink coating the glass tube. Also, we experimentally produced a new type torsional phaco[for full text, please go to the a.m. URL], 26. Internationaler Kongress der Deutschen Ophthalmochirurgen

Solid oxide fuel cells are among the most thermodynamically efficient energy conversion devices. They are critical for the future if we are to meet rising energy demands and increasing selectivity over our future energy mix. Traditionally, solid oxide fuel cell performance has been assessed using bulk parameters, and the microstructure-bulk properties relationship is yet to be well understood. Here, we use time-lapse 3D imaging to probe 3D electrode structure and move towards intelligently designing structures with specific performance attributes. Using 3D imaging allows for characterisation and quantification of parameters that are not well described in 2D, such as triple-phase boundary lengths, tortuosity and phase percolation. In this work, the parameters for an optimised porous nickel-scandia stabilized zirconia anode (Ni-ScSZ) were calculated using an electrochemical model to maximise triple-phase boundary length and density, gas permeation and electronic and ionic transport. Ni-ScSZ scaffolds were then produced using screen-printing and impregnation and characterized with FIB-SEM to obtain 3D microstructural parameters such as actual percolation of the phases, tortuosity and connectivity of the phases, and the length and density of triple-phase boundaries (Figure 1). The experimental microstructural parameters were then compared to the modelled optimised microstructure, allowing for an examination of the accuracy of the manufacturing parameters. Symmetrical cells were set up to compare the anode performance with the performance predicted by the electrochemical model. Early iterations of impregnated scaffolds show triple-phase boundary densities increased by approximately an order of magnitude and allowed for a critical assessment of the electrochemical model. The degraded electrode morphology was also characterized in 3D to link its changes during cycling to performance degradation. This approach enables us to move towards designing optimised electrodes with specific performance attributes. Figure 1

Global demands for energy storage, supply and portability has seen continual increase. Meeting these demands in a clean efficient manner will be expedited through an ability to directly image energy devices such as SOFC electrodes, in 3D, at high resolutions. Tomographic techniques allow for the 3D imaging and characterisation of complex electrode microstructures down towards tens of nanometers; which are inadequately described in 2D. The performance of the electrode is dependent on nano/micro-structure as the electrochemical reactions and transport phenomena are strongly affected by the complex porous structure. Furthermore, during processing or operation microstructural evolution may degrade electrochemical performance. However, although many studies have utilised 3D imaging, there is a need to understand the information beyond common metrics .e.g. porosity and tortuosity and pretty pictures. Increasingly large quantities of 3D or time-resolved 3D electrode data are simultaneously acquired and yet poorly understood, simply in favour of more 3D data acquisition. Here we use tomographic techniques (X-ray & FIBSEM) to probe the 3D SOFC electrode structure at nanometer to micrometer length scales. Advanced characterisation of particle specific attributes e.g. necks, interfaces and particle clustering within SOFC electrodes is derived; the electrode is not treated as three monolithic phases. The electrode is quantified as the interaction of particles of three phases. Micro/nano structural changes are followed to facilitate understanding the differences which occur with shape, structures and morphology at high resolution. Results reveal clustering behaviour of particles. The results are also correlated with measured experimental values to provide insight into microstructure-property relationships. We correlate models and this advanced 3D quantitative analysis. In doing so, altogether this work provides important insights for electrode design, enabling 3D optimised structures to be created and understanding sources of performance degradation. Figure 1

Purpose: The potential of research into irrigation as a way of contributing to the progress of cataract surgery. Method: I modified an i-Pod amplifier and attached it to the hand piece as shown here, offering power over 200 volts. In this PEA experiment using a porcine eye and the ultrasound machine,[for full text, please go to the a.m. URL], 22. Internationaler Kongress der Deutschen Ophthalmochirurgen

We present results from very high signal-to-noise spectropolarimetric observations of the Seyfert 1 galaxy NGC 3783. Position Angle (PA) changes across the Balmer lines show that the scatterer is resolving the Broad-Emission Line Region (BLR). A broad component seen in polarized light and located bluewards from the H$\beta$ line very likely corresponds to HeII$\lambda4686$. The lack of PA changes across this line suggests that the region responsible for this emission appears to the scatterer as unresolved as the continuum source, in agreement with the stratified BLR structure determined from reverberation mapping., Comment: Conference proceedings to appear in "The Central Engine of Active Galactic Nuclei", ed. L. C. Ho and J.-M. Wang (San Francisco: ASP)

Thermal models for the quasar Big Blue Bump generally lead to bound-free continuum features, which may be in absorption or emission. Searches for Lyman edges attributable to quasar atmospheres (in particular accretion disk atmospheres) have been ambiguous at best, but various relativistic and non-LTE effects may make them hard to detect. The Balmer edge features tentatively predicted by such models might be easier to detect since they'd form farther out in the potential wells. These can be sought in certain cases using spectropolarimetry to remove the effects of atomic emission (i.e. the Small Blue Bump) from the spectrum. We do find apparent Balmer edges in absorption in several quasars using this method! Although the features we see are believable and apparently common, more data and more modeling are needed to verify that they are best interpreted as atmospheric Balmer edges., To appear in the proceedings of "AGN Physics with the SDSS", eds. G. T. Richards and P. B. Hall (San Francisco: ASP) (2004)

RhoF is a member of the Rho GTPase family that has been implicated in various cell functions including long filopodia formation, adhesion, and migration of cells. Although RhoF is expressed in lymphoid tissues, the roles of RhoF in B cell development remain largely unclear. On the other hand, other members of the Rho GTPase family, such as Cdc42, RhoA, and Rac, have been intensively studied and are known to be required for B cell development in the bone marrow and spleen. We hypothesized that RhoF is also involved in B cell development. To examine our hypothesis, we analyzed B cell development in RhoF knockout (KO) mice and found a significant reduction in marginal zone (MZ) B cells in the spleen, although T cell development in the thymus and spleen was not affected. Consistent with these results, the width of the MZ B cell region in the spleen was significantly reduced in the RhoF KO mice. However, the antigen-specific antibody titer of IgM and IgG3 after MZ B cell-specific antigen (T cell-independent antigen, type I) stimulation was not affected by RhoF deletion. Furthermore, we demonstrated that RhoF was dispensable for stromal cell-derived factor-1α- and B lymphocyte chemoattractant-induced B cell migration. These results suggest that RhoF promotes MZ B cell development in the spleen.

The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to ~100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the "Hill Sphere" of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs., S.K. acknowledges support from an STFC Rutherford Fellowship (ST/J004030/1) and Philip Leverhulme Prize (PLP-2013-110). Part of this work was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

We have previously reported that a complementary peptide (denoted RhCA 67-16), encoded by RNA complementary to that of the Torpedo acetylcholine receptor (AChR) main immunogenic region (MIR), AChR residues alpha 61-76, induces polyclonal and monoclonal Ab reactive with Ig against the AChR MIR. RhCA 67-16 vaccination also protected against the development of experimental autoimmune myasthenia gravis (EAMG) in Lewis rats. In the present report, we found that a mAb (denoted TCM 240, IgG1 kappa) against RhCA 67-16 recognized three different idiotypic Ab (mAb 6, mAb 35, and mAb 198), which were previously reported by others to recognize the AChR MIR and to cause EAMG. Based on these results, TCM 240 was tested for prophylactic effects in EAMG. EAMG induced passively by mAb 35 was inhibited by simultaneous injection with TCM 240. The disease severity was inversely paralleled by the ratio of mAb 35 to TCM 240. EAMG induced by immunization with purified native Torpedo AChR was also inhibited by TCM 240, but not a control mAb. The inhibitory effect of TCM 240 on actively induced EAMG occurred without significantly lowering the overall AChR Ab levels, which indicates a limited repertoire of disease-causing Ab in EAMG and perhaps MG. Such findings suggest the existence of an EAMG-associated Id and also support the concept of an MIR. In a more general sense, these results demonstrate that prophylactic and perhaps diagnostic mAb for autoimmune diseases can be produced by immunization with complementary peptides for disease-associated epitopes.

We present multi-wavelength spectral and temporal variability analysis of PKS 0027-426 using optical griz observations from DES (Dark Energy Survey) between 2013-2018 and VOILETTE (VEILS Optical Light curves of Extragalactic TransienT Events) between 2018-2019 and near infrared (NIR) JKs observations from VEILS (VISTAExtragalactic Infrared Legacy Survey) between 2017-2019. Multiple methods of cross-correlation of each combination of light curve provides measurements of possible lags between optical-optical, optical-NIR, and NIR-NIR emission, for each observation season and for the entire observational period. Inter-band time lag measurements consistently suggest either simultaneous emission or delays between emission regions on timescales smaller than the cadences of observations. The colour-magnitude relation between each combination of filters was also studied to determine the spectral behaviour of PKS 0027-426. Our results demonstrate complex colour behaviour that changes between bluer when brighter (BWB), stable when brighter (SWB) and redder when brighter (RWB) trends over different timescales and using different combinations of optical filters. Additional analysis of the optical spectra is performed to provide further understanding of this complex spectral behaviour., Accepted for publication in MNRAS. 33 pages, 28 figures, 11 tables