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Covid-19 pandemic has led to a global health crisis, with more than 607 million infections and 6 million deaths. Vaccination is known to be the most effective medical intervention to control a pandemic situation, and as a result, mass vaccination efforts against SARS-CoV-2 infection continue. Recently, concerns have been raised about diabetic adverse events following covid-19 vaccination. Previous studies have been reported new-onset diabetes or severe hyperglycemic conditions in both short and long periods after covid-19 vaccination. Indeed, inflammatory reactions induced by the vaccine might trigger activation of autoimmune cascade or alterations in glucose metabolism. Moreover, new-onset diabetes or severe hyperglycemic conditions after SARS-CoV-2 infection has been previously reported. In particular, SARS-CoV-2 infection might lead to diabetogenic through systematic cytokine storm or direct attack of pancreatic cells with expressing angiotensin-converting enzyme-2 receptors. Taken together, since both covid-19 vaccination and SARS-CoV-2 infection have the possibility to cause diabetic disorders, clinical risk-benefit of vaccination should be derived through epidemiological study using large-scale routinely collected data.