1. Assessment of atrioventricular valve regurgitation using biomechanical cardiac modeling
- Author
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Chabiniok, Radomir, Moireau, Philippe, Kiesewetter, Christoph, Hussain, Tarique, Razavi, Reza, Chapelle, Dominique, Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, University of Texas Southwestern Medical Center [Dallas], Pop M and Wright G, Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
- Subjects
therapy planning ,reduced-order model ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,atrioventricular regurgitation ,model-based diagnosis assistance ,cardiac modeling - Abstract
International audience; In this work we introduce the modeling of atrioventricular valve regurgitation in a spatially reduced order biomechanical heart model. The model can be fast calibrated using non-invasive data of cardiac magnetic resonance imaging and provides an objective measure of contractile properties of the myocardium in the volume overloaded ven-tricle, for which the real systolic function may be masked by the significant level of the atrioventricular valve regurgitation. After demonstrating such diagnostic capabilities, we show the potential of modeling to address some clinical questions concerning possible therapeutic interventions for specific patients. The fast running of the model allows targeting specific questions of referring clinicians in a clinically acceptable time.
- Published
- 2017