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In this study, the aim was to determine the effectiveness of internal teat sealant applied at the dry-off in preventing the formation of subclinical mastitis and to investigate whether this product could be a non-antibiotic alternative to total dry cow treatment. A total of 195 quarters from 52 Holstein and Holstein Crossbreed dairy cows, that did not have clinical mammary infection and were expected to calve within 60 days were used in the study. The quarters were divided into 3 treatment groups as follows: Group 1 (ANTB; n = 64): dry period intramammary antibiotic suspension (Ubrostar®); Group 2 (ORB; n = 65), internal teat sealant (Orbeseal®); and Group 3 (ANTB-ORB; n = 66) intramammary antibiotic and teat sealant combination were performed. All of the quarters were checked for subclinical mastitis on the 20th, 40th and 60th days of lactation. The percentage of animals found to be CMT negative on the 20th day of lactation was 80.65% in G1 (ANTB), 83.60% in Group 2 (ORB), and 87.50% in Group 3 (ANTB-ORB), respectively. There was no quarter with CMT +3 score in G1 and G3, but it was determined in one quarter in G2 (ORB). On the 60th day there were no quarters with CMT +2 and +3 scores in both G1 and G2. No statistically significant difference was found between the CMT results of treatment groups on the 20th, 40th and 60th days of lactation (p > 0.05). In conclusion, it was determined that bismuth subnitrate-based teat canal sealer provided good protection against subclinical mastitis rate in drying healthy udder quarters. However, especially in high risk groups it is important to closely monitor udder health with SCC and/or CMT applications before the dry period and to choose the dry period treatment.

Cytosine methylation is a pervasive DNA modification in vertebrate genomes that occurs predominantly in the context of sparsely distributed CpG dinucleotides. In contrast to the bulk genome, short genomic elements referred to as CpG islands (CGIs) feature a high GC content and clusters of non-methylated CpGs. CGIs co-localise with the majority of gene promoters where their distinct DNA sequence features enables the recruitment and assembly of transcription regulating complexes. Thus, as sites of transcription initiation, CGIs exert an important function in controlling promoter activity and gene expression. Despite their importance, it remains unclear how this is mechanistically achieved and how CGI dysfunction contributes to diseases such as cancer. This is largely due to the fact that the majority of our mechanistic insights into CGI function come from candidate-based approaches such as chromatin immunoprecipitation coupled to sequencing, which are inherently biased and limit us to investigating one protein at a time. The capacity to attribute detailed mechanistic understanding to CGI function has been hampered by our lack of a comprehensive inventory of proteins that contribute to their maintenance and function. To overcome this fundamental lack of understanding, I have developed a new biochemical approach to isolate CGI chromatin from the bulk genome in order to investigate the CGI proteome in an unbiased manner using mass spectrometry. Applying next generation sequencing, I validated on the genome level that this method is suitable for specific enrichment of CGIs from mouse embryonic stem cells. Mass spectrometry data revealed many known CGI interactors, and it provided new leads for further investigation of potentially novel CGI-associated proteins. By deleting selected components of the CGI proteome, I uncovered CGI protein composition changes that pointed to new interrelations between the components of the gene regulation network at CGI promoters. Finally, using calibrated ChIP-sequencing as an orthogonal approach, I verified for selected proteins that the CGI proteome alterations were caused by changes in genomic occupancy. In conclusion, this work presents the first method to investigate the CGI proteome and its alterations comprehensively and unbiasedly in different conditions. Ultimately, this method can advance our knowledge of how CGIs contribute to gene regulation in developmental processes and pathogenesis.

Derya Kaya,1 Ali Ekrem Aydin,2 Ahmet Turan Isik1 1Unit for Brain Aging and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey; 2Department of Geriatric Medicine, Sivas State Hospital, Sivas, TurkeyCorrespondence: Derya KayaUnit for Brain Aging and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylül University, Balçova, Izmir 35340, TurkeyTel +90 232 412 43 41Fax +90 232 412 43 39Email deryakaya29@gmail.comPurpose: Essential tremor (ET) is the most common movement disorder in which dysautonomia symptoms can be present. We aimed to evaluate the presence of orthostatic hypotension (OH) and its relationship with the clinical features.Patients and Methods: Forty-four elderly patients with ET and 118 healthy elderly controls were included. OH was assessed via the head-up tilt table test and defined, according to the change in position, as a drop of at least 20 mmHg in systolic blood pressure and/or 10 mmHg in diastolic blood pressure. Tremor severity was evaluated using the Fahn-Tolosa-Marin Tremor Rating (FTMTR) Scale. All patients underwent geriatric comprehensive assessment.Results: There were no differences between the controls and patients with ET regarding age and gender. The mean age was 72.8± 6.1, the mean disease duration 19.1± 13.5 years and the mean FTMTR score was 30.9± 17.1 in patients with ET. The frequency of OH at the 1st minute in patients with ET was higher than in controls (31.8% vs 17.8%, p=0.046). Furthermore, the frequency of jaw tremor in patients with OH was higher than in those without OH (35.7% vs 6.7%, p=0.025). About 28.6% of ET patients with OH had orthostatic symptoms.Conclusion: We demonstrated that ET patients, particularly those with jaw tremors, had OH and that most of them were asymptomatic. Therefore, in order to protect patients from complications related to OH, it would be appropriate to evaluate OH in the follow-up and treatment of elderly patients with ET.Keywords: essential tremor, orthostatic hypotension, head-up tilt table test, jaw tremor, elderly

This correlational study aimed to explore the relations of background knowledge, automaticity (rate), prosody, and strategy use with reading comprehension (KAPS model of reading comprehension) in the written Turkish language context with 207 fourth grade students. Successful comprehension requires readers to make meaning out of what they read. Our KAPS model of reading comprehension hypothesizes relations of background knowledge, fluency components (rate and prosody), and strategy use with reading comprehension components (literal and deep) in the Turkish language and addresses the direct effects of these predictors on the reading comprehension of fourth grade students. The results showed that, whereas fluency and strategy use made statistically significant contributions to reading comprehension, background knowledge did not. Based on the results, the study affirms the importance of automaticity in word recognition, prosody, and comprehension strategies in contributing to reading comprehension in Turkish and, as such, should be given priority for literacy instruction in Turkish. C1 [Yildirim, Kasim] Mugla Sitki Kocman Univ, Dept Elementary Educ, TR-48000 Mentese Mugla, Turkey. [Cetinkaya, Fatih Cetin] Duzce Univ, Dept Elementary Educ, TR-81620 Duzce, Turkey. [Ates, Seyit] Gazi Univ, Dept Elementary Educ, TR-06500 Yenimahalle Ankara, Turkey. [Kaya, Dudu] Pamukkale Univ, Dept Elementary Educ, TR-20160 Pamukkale, Turkey. [Rasinski, Timothy] Kent State Univ, Dept Literacy Educ, Kent, OH 44242 USA.

BACKGROUND AND OBJECTIVE: The purpose of this study was to determine the effect of surgical treatment on ocular findings in obstructive sleep apnea syndrome (OSAS).

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The present study attempted to extend our knowledge of the role of reading fluency in contributing to reading comprehension among Turkish students in grades 4 through 8. One hundred students at each grade level were administered assessments of reading fluency, word recognition automaticity and prosody, and silent reading comprehension. Word recognition automaticity was found to be a significant predictor of comprehension at all grade levels tested. Prosody predicted comprehension at all grades levels except grade 4. Regression analyses at each grade level indicate that, except for grade 4, word recognition automaticity and prosody, together contribute to the prediction of reading comprehension. The magnitude of fluency's prediction of comprehension ranged from approximately a quarter to a third of comprehension. The results are discussed in terms of policy and instructional changes that may be considered for reading instruction for Turkish students. C1 [Yildirim, Kasim] Mugla Sitki Kocman Univ, Elementary Sch Classroom Teaching, Mugla, Turkey. [Rasinski, Timothy] Kent State Univ, Sch Teaching Learning & Curriculum Studies, Kent, OH 44242 USA. [Kaya, Dudu] Pamukkale Univ, Elementary Sch Classroom Teaching, Denizli, Turkey.

Objectives: Over the years various clinical and experimental studies evidenced the positive effect of traumatic brain injury (TBI) on callus formation in long bone fractures (Fx). As impaired fracture healing still remains of great relevance in the clinic, identifying the key mediators involved holds[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Objectives: Recently, our group established a murine model combining traumatic brain injury (TBI) and a femoral fracture (Fx). Similar to humans, TBI resulted in accelerated fracture healing in this model. Alterations in energy utilization may provide an explanation for this phenomenon, as metabolic[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Background: Perinatal and perioperative brain injury is a fundamental problem in infants with severe congenital heart disease undergoing neonatal cardiac surgery with cardiopulmonary bypass. An impaired neuromotor and neurocognitive development is encountered and associated with a reduction in quality of life. New neuroprotective drugs during surgery are described to reduce brain injury and improve neurodevelopmental outcome. Therefore, our aim was to provide a systematic review and best-evidence synthesis on the effects of neuroprotective drugs on brain injury and neurodevelopmental outcome in congenital heart disease infants requiring cardiac surgery with cardiopulmonary bypass. Methods: A systematic search was performed in PubMed, Embase and the Cochrane Library (PRISMA statement). Search terms were “infants,” “congenital heart disease,” “cardiac surgery,” “cardiopulmonary bypass,” and “neuroprotective drug.” Data describing the effects on brain injury and neurodevelopmental outcome were extracted. Study quality was assessed with the Cochrane Risk of Bias Tool. Two reviewers independently screened sources, extracted data and scored bias. Disagreements were resolved by involving a third researcher. Results: The search identified 293 studies of which 6 were included. In total 527 patients with various congenital heart diseases participated with an average of 88 infants (13–318) per study. Allopurinol, sodium nitroprusside, erythropoietin, ketamine, dextromethorphan and phentolamine were administered around cardiac surgery with cardiopulmonary bypass. Allopurinol showed less seizures, coma, death and cardiac events in hypoplastic left heart syndrome (HLHS) infants (OR: 0.44; 95%-CI:0.21–0.91). Sodium nitroprusside resulted in lower post cardiopulmonary bypass levels of S100s in infants with transposition of the great arteries after 24 (p < 0.01) and 48 (p = 0.04) h of treatment. Erytropoietin, ketamine and dextromethorphan showed no neuroprotective effects. Phentolamine led to higher S100s-levels and cerebrovascular resistance after rewarming and at the end of surgery (both p < 0.01). Risk of bias varied between studies, including low (sodium nitroprusside, phentolamine), moderate (ketamine, dextromethorphan), and high (erytropoietin, allopurinol) quality. Conclusions: Allopurinol seems promising for future trials in congenital heart disease infants to reduce brain injury given the early neuroprotective effects in hypoplastic left heart syndrome infants. Larger well-designed trials are needed to assess the neuroprotective effects of sodium nitroprusside, erytropoietin, ketamine and dextromethorphan. Future neuroprotective studies in congenital heart disease infants should not only focus on the perioperative period, however also on the perinatal period, since significant brain injury already exists before surgery.

Objective: To evaluate the anterior segment findings measured via corneal topography of patients with obstructive sleep apnea syndrome (OSAS) and to compare the findings with normal subjects. Methods: A total of 43 eyes from 43 patients with OSAS and 43 eyes from 43 healthy persons who were referred to eye clinics from 2012 to 2016 were randomly selected and included in this retrospective study. Routine eye examination and anterior segment findings measured via corneal topography were recorded for both groups. Central corneal thickness (CCT), keratometry values (K1, K2, and Kmax), corneal volume (CV), anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) of the two groups were compared. Results: The mean CCT values of the control and OSAS groups were 567.23 +/- 31.17 and 544.4 +/- 36.44 (p=0.002), respectively. The mean CV (HR) was found to be 60.51 +/- 8.44 in the control group and 59.78 +/- 3.47 in the OSAS group (p=0.04). There was no statistically significant difference between the OSAS and control groups in terms of mean age, K1, K2, Kmax, ACV, ACD, and ACA (p>0.05). The mean apnea/hypopnea index (AHI) score of the OSAS group was found to be 21.82 +/- 12.79. There was no negative or positive correlation between the AHI score and age, CCT, K1, K2, Km, SCL, SCL, SCA, and CV. Conclusion: Central corneal thickness and CV are lower in OSAS patients than in normal people.

Gulhane Military Medical Academy, Aim: This study was carried out to determine the prevalence of premenstrual syndrome (PMS) in nursing and midwifery students and the correlation between smoking behavior and the PMS. Methods: The sample of study consisted of 584 nursing and midwifery students (Nursing studens:334, midwifery students:250). There quired data were collected with Individual and Smoking Behavior Characteristics Form, Premenstrual Syndrome Scale (PMS) and Fagerstrom Nicotine Tolerance Test (FNTT). Data were evaluated with Chi-Square tests and Oneway Anova. Results: The average age of the students was 19.94±1.77. The average age of menarche 13.27±1.19 and of 53.6% of students have regular menstrual cycle. The prevalence of PMS was 33% in the study group. Compared to the prevalenc e of PMS according to smoking status, it was found significant difference. Prevalence of PMS is lowest (28.7%) in students who never smoke during their life, while this ratio is 52.9%. The average PMS score was 98.15±35.83. When the total and subscale average scores of PMS were examined according to smoking status, it was found that total and subscale average scores of PMS to be significantly lower than those currently smoking andex-smoking(p0.05). Conclusion: Because, even once smoking is a factor affecting the prevalence of PMS among young girls, it is recommended activities preventing to start smoking and developing written and visual material about smoking prevention. © GATA., Gölbaşı, Z.; Doğum ve Kadın Hastalıkları Hemşireliği Anabilim Dalı, Hemşirelik Bölümü, Sağlık Bilimleri Fakültesi, Cumhuriyet ÜniversitesiTurkey; email: zehragolbasi@gmail.com

The present study attempted to extend knowledge of the role of reading fluency in contributing to reading comprehension of expository texts among Turkish students in grades four through eight. One hundred students at each grade level were administered assessments of two measures of reading fluency, word recognition automaticity and prosody, and silent reading comprehension. Word recognition automaticity was found to be a significant predictor of comprehension at all grade levels tested. Prosody predicted comprehension at all grades levels as well except for grades 4 and 5. Regression analyses at each grade level indicates that, except for grades 4 and 5, word recognition automaticity and prosody together contribute to the prediction of reading comprehension. The magnitude of fluency's prediction of comprehension ranged from approximately a quarter to a third of the variance in comprehension. The results are discussed in terms of policy and instructional changes that may be considered in reading instruction for Turkish students.

Objective: Alcohol is widely used in the world and can cause gastrointestinal (GI) disturbances. Elucidating the molecular mechanism of alcohol in the GI tract may contribute to the therapeutic approaches on GI diseases caused by alcohol. So in the present study we aimed to elucidate the molecular mechanism of ethanol on isolated mouse gastric fundus. We investigated the role of nitric oxide and sodium-potassium-exchanging ATPase on relaxations induced by ethanol in the related tissue. Material and Methods: Mice (Swiss albino) of either sex were used in this study. After killing the mice by cervical dislocation the gastric fundal strips were prepared by longitudinal incision and mounted under 0.5 g tension in an organ bath filled with Tyrode’s solution. The bath medium was maintained at 37°C and gassed with 95% O2 and 5% CO2. After equlibrium period of an hour, the basal tonus of isolated mouse gastric fundal strip was recorded for 5 minutes and ethanol was applied into organ bath (the final concentration of ethanol in the organ bath medium was 164 mM). Results: Ethanol (164 mM) caused reproducible relaxations in isolated mouse gastric fundal strips. These relaxations were statistically significantly inhibited by N?-Nitro-L-arginine (L-NOARG; 10-5-5×10-4 M), a potent and specific inhibitor of nitric oxide synthase, in a concentration dependent manner. On the other hand ouabain (10-5-10-4 M), a potent and specific inhibitor of the sodium-potassium-exchanging ATPase, failed to affect the relaxations induced by ethanol (164 mM) in the mouse gastric fundus. Conclusion: The results of experimental data suggest that nitric oxide may play a role on relaxations induced by ethanol in the isolated mouse gastric fundal smooth muscle. The results also suggest that sodium-potassiumexchanging ATPase may not have a role on relaxations induced by ethanol in the related tissue. © 2017 by Türkiye Klinikleri.

Tukay’ın bazı eserlerindeki söylemlerinden hareketle onun bir ateist olduğu yolunda bazı görüşler Tatar edebiyat çevrelerince bir dönem tartışılan bir konu olmuştur. Bu yolda yazılan kitaplardan biri de Z. A. İşmöhemmetov’un “Tukay Ateizmi” adlı kitabıdır. Bu makalede Tukay’ın şiirlerinden örneklerle onun asla bir ateist olmadığı, yalnızca dinî bir araç olarak kullanan din istismarcılarına karşı olduğu, dolayısıyla adı geçen kitabın yersiz fikirler içerdiği gibi konular ele alınmaktadır.

XX. yüzyıl Tatar yazı dili içerisinde Abdullah Tukay’ın dili kendine has özellikleriyle belirmektedir. Eserlerinde Kıpçakça ve Çağatayca gibi tarihî yazı dillerinden sözlere de yer veren Tukay, Oğuzcanın sözlerini de dönemin Osmanlıca eğilimine uyarak kullanmıştır. Bu makalede, Tukay’ın eserlerinde kullandığı bu tür sözler, çağdaş Tatar yazı dili ve ağızları ile karşılaştırılarak bazı sonuçlara varılmaktadır.

48th Annual Conference on Physiology and Pathology of Reproduction / 40th Joint Congress of Veterinary and Human Medicine -- FEB 11-13, 2015 -- Zurich, SWITZERLAND Kucukaslan, Ibrahim/0000-0002-3458-4409; FINDIK, Murat/0000-0003-1408-2548; WOS: 000349104800154 …

This article focuses on Birleşen Yollar/Crossroads (Yücel Çakmakl, 1970), which pioneered the Islamic National Cinema Movement in Turkey. The film discursively constructed Turkish secularist modernization as cosmetic Westernization and promoted the Islami Department of Radio, Television and Cinema, Yaşar University, Üniversite Caddesi 37-39, Bornova, Izmir, 35100, Turkey; Department of International Relations, Okan University, Istanbul, Turkey

This article summarizes the results of a study for a 100 kWe DC electrical power PEM fuel cell system. The system consists of a pre-steam reformer, a steam reformer, high and low temperature shift reactors, a preferential oxidation reactor, a PEM fuel cell, a combustor, and an expander. Acceptable net electrical efficiency levels can be achieved via intensive heat integration within the PEM fuel cell system. The calculations take into account the auxiliary equipment such as pumps, compressors, heaters, coolers, heat exchangers and pipes. The process simulation package "Aspen-HYSYS 3.1" has been used. The operation parameters of the reactors have been determined considering all the technical limitations involved. A gasoline type hydrocarbon fuel has been studied as hydrogen rich gas source. Thermal efficiencies have been calculated for all of the major system components for selected operation conditions. The fuel cell stack efficiency has been calculated as a function of cell numbers (500, 750, 1000, and 1250 cells). Efficiencies of all of the major system components along with auxiliary unit efficiencies determine the net electrical efficiency of the PEM fuel cell system. The obtained net electrical efficiency levels are between 34 (500 cells) to 41% (1250 cells).

FINDIK, Murat/0000-0003-1408-2548 WOS: 000337967900005 PubMed: 24947857 Contents Pre-pubertal gonadectomy in dogs and cats is still controversially discussed because some consequences cause health problems. Nevertheless, postponement of puberty, that is, prevention of an increase in sexual hormones and thereby prevention of their manifold effects, is of major importance, not only in controlling overpopulation but also to preserve the genetic base for future breeding stock and pets. Therefore, alternatives for surgical suppression of fertility in pre-pubertal animals were critically reviewed. As a promising alternative, the slow-release GnRH agonist deslorelin and other GnRH analogues have been investigated. In female dogs and cats, puberty could be significantly postponed without initial flare-up effect and without disturbance of body development. First trials to delay puberty in female and male cats by application of a 4.7-mg deslorelin implant 24h after birth so far are promising. In female dogs, a previous investigation showed that when the implant was inserted at the age of 4months, the initial flare-up effect was prevented. Body development was normal in the studies reviewed here, and with the 9.4-mg implant, puberty was significantly delayed until the age of 21months or older. In one study, bitches either received a 4.7- or a 9.4-mg implant at the age of 4months and the epiphyses were mostly closed before the time of first oestrus. Using a 4.7-mg deslorelin implant in pre-pubertal male dogs significantly postponed puberty, and age at puberty was >2years when a 9.4-mg implant was used. However, further investigations are required, especially concerning the effect of different GnRH agonist dosages and resorption rates on the duration of postponement of puberty as well as long-term effects in both dogs and cats.

18th Annual Conference of the European-Society-for-Domestic-Animal-Reproduction (ESDAR) -- SEP 11-13, 2014 -- Helsinki, FINLAND Kucukaslan, Ibrahim/0000-0002-3458-4409; FINDIK, Murat/0000-0003-1408-2548 WOS: 000342824200167 … European Soc Domest Anim Reprod

GIRAY, Semih/0000-0002-0722-3181; Kaya, Dilaver/0000-0002-7364-171X; UZUNER, NEVZAT/0000-0002-4961-4332 WOS: 000345767700238 …

The aim of this study was to develop new natural compounds based on collagen hydrolysate modified with lavender essential oils. The essential oils were extracted by hydrodistillation from aerial parts of Lavender officinalis L. and Lavender stoechas L. subsp. stoechas with the yield of 3.0 and 3.6% respectively. The chemical composition determined by GC-MS analyses showed that fenchone (45.47%), 1.8 cineol (19.47%) and camphor (17.23%) were the main components for L. stoechas oil, while for L. officinalis, linalool (28.00%) linalyl acetate (43.96%) and camphor (5.94%) were found in high concentrations. The main groups of essential oils were identified also by FT-IR. Natural compounds with 75:25, 50:50 and 25:75 ratios (w/w) were prepared by collagen hydrolysate with 6000 Da and lavender essential oils. The modifications of collagen hydrolysate as a result of lavender essential oil interactions were determined by FT-IR. The results showed that L. stoechas essential oil was linked stronger on collagen due to higher content of ketones comparing with L. officinalis which is rich in alcohols and esters. The essential oils were bonded on side chain of amino acids from collagen hydrolysate. The new obtained compounds could be used as basic natural ingredients in medical, pharmaceutical and cosmetic fields, as they are products with added value, keeping the therapeutic properties of both collagen and essential oils.

WOS: 000328301100018 The aim of this study was to investigate the effects of dietary Trigonella foenum-graceum L. seed powder (TFGSP) on growth performance, blood glucose, protein and lipid profile of broilers (Ross-308). One hundred ninety two, 1-d old mixed sex broiler chicks were allocated to 5 dietary treatments in which 0, 5, 10, 20 and 40 g TFGSP doses per kg commercial broiler diet were added for a period of 42 days. The results showed that body weight and the breast weight decreased after TFGSP treatment compared to control (P

The present study is aimed at evaluating the effectiveness of combined preventive treatment with Ceftiofur Hydrochloride (CHR), Oxytocin (OXT) and PGF2? on fertility parameters and puerperal disorder rates in postpartum (pp) dairy cows. A total of 191 Holstein-Friesian cows were divided into four groups. The cows in group I (GI; n=37) and II (GII; n=69) were treated on a daily basis with CHR and OXT for five and three days pp, respectively. Group III (GIII; n=52) was designed as the PGF2? group, and group IV (GIV; n=33) served as a control group. The animals in GI, GII, and GIII were given a PGF2? analogue on days 15 and 26 pp. Each group was further divided into subgroups of normal parturition (np) and dystocia (d) when the study results were evaluated. It was found that the first service pregnancy rates for the subgroup of dystocia were significantly higher (P0.05). As the treatment with CHR-OXT combined with PGF2? on days 15 and 26 was associated to improved uterine involution patterns and reproductive performance, our results suggest that administration of this preventive treatment would be useful, especially for cases of dystocia.

Kucukaslan, Ibrahim/0000-0002-3458-4409; FINDIK, Murat/0000-0003-1408-2548 WOS: 000311653800002 This study examined the effects of Beta-carotene (beta C) injections before estrus synchronization with PGF(2)alpha on fertility parameters in cows. A total of 124 postpartum (pp) cows were used. In GI (n=25), beta C (Carofertin (R), 0.4 mg/kgBW, i.m.) was injected on d 15 and 45 pp. In GII (n=25), beta C was administered on d 15 pp. In GIII (n=25), beta C was administered on d 45 pp. In GIV (n=25), beta C was injected on d 35 and 45 pp. GV (n=24) was set aside as a control group. All animals received PGF(2)alpha (Iliren (R), 0.0015 mg/kgBW, i.m.) on d 50 and 61 pp. Blood samples were collected on d 15,48 and three days after each beta C injection. The overall pregnancy rate was determined to be higher in GI (100%) and GIV (88.0%) than GV (70.8%) (P

This study examined the effects of Beta-carotene (?C) injections before estrus synchronization with PGF 2? on fertility parameters in cows. A total of 124 postpartum (pp) cows were used. In GI (n=25), ?C (Carofertin®, 0.4 mg/kgBW, i.m.) was injected on d 15 and 45 pp. In GII (n=25), ?C was administered on d 15 pp. In GIII (n=25), ?C was administered on d 45 pp. In GIV (n=25), ?C was injected on d 35 and 45 pp. GV (n=24) was set aside as a control group. All animals received PGF 2? (Iliren®, 0.0015 mg/kgBW, i.m.) on d 50 and 61 pp. Blood samples were collected on d 15, 48 and three days after each ?C injection. The overall pregnancy rate was determined to be higher in GI (100%) and GIV (88.0%) than GV (70.8%) (P

The aim of the present study was to determine the effect of essential oils on antioxidant and antimicrobial properties of collagen hydrolysate. The essential oils were obtained from Laurus nobilis L. (3,7%) and Thymbra spicata L. (4,1%) and they were characterized by GC-MS. Collagen hydrolysate obtained by biotechnological process was modified by essential oils and hydroalcoholic solutions with 0.25, 0.50, 1.0 and 2.0% thymbra and laurel oil were prepared. These hydroalcoholic solutions were characterized by antioxidant activity and antimicrobial activity against Escherichia coli. The antioxidant activity was more effective for the combination between hydrolysate and essential oils and increased with essential oils concentration increase. Based on its properties the hydroalcoholic solution with collagen hydrolysate and 2% thymbra oil proved the best antioxidant and antimicrobial activity in order to be use in medical, pharmaceutical, cosmetic, biotechnology and food industry.

Aim: To evaluate the possible roles of phospholipase C, protein kinase C, and endothelin-converting enzyme on contractions induced by ethanol (164 mM) in isolated gastric fundal strips of mice. Materials and methods: After the mice were killed, the stomach of each was removed and longitudinal muscle strips were prepared from the gastric fundus. The strips were mounted in organ baths and their responses were recorded isometrically. Ethanol (164 mM) was added to the organ baths and a steady-state contraction was obtained. After the first ethanol response was recorded, the preparations were incubated separately with lidocaine (1-100 µM), neomycin (10-500µµM), safingol (0.5-5µµM), and SM-19712 (1-50 µM) for 40 min. The second ethanol response was then examined in the presence of the drug used in the incubation period. Results: Lidocaine (1-100 µM), a local anesthetic agent, did not modulate the contractions induced by ethanol in isolated gastric fundal strips of mice. In contrast, neomycin (10-500 µM), a selective inhibitor of phospholipase C, and safingol (0.5-5 µM), a selective inhibitor of protein kinase C, decreased the ethanol-induced contractions. SM-19712 (1-50 µM), a selective inhibitor of endothelin-converting enzyme, failed to affect these contractions. Conclusion: The contractile effect of ethanol may be muscular rather than neuronal in the gastric fundal strips of mice. In addition, phospholipase C and protein kinase C pathways may have a role in contractions due to ethanol in the mouse gastric fundus. On the other hand, endothelin-converting enzyme may not have a regulatory role in the contractile responses of ethanol in the same tissue. © TÜBİTAK.

FINDIK, Murat/0000-0003-1408-2548; Kucukaslan, Ibrahim/0000-0002-3458-4409 WOS: 000311653600008 The present study is aimed at evaluating the effectiveness of combined preventive treatment with Ceftiofur Hydrochloride (CHR), Oxytocin (OXT) and PGF(2 alpha) on fertility parameters and puerperal disorder rates in postpartum (pp) dairy cows. A total of 191 Holstein-Friesian cows were divided into four groups. The cows in group I (GI; n=37) and II (GII; n=69) were treated on a daily basis with CHR and OXT for five and three days pp, respectively. Group III (GIII; n=52) was designed as the PGF(2 alpha) group, and group IV (GIV; n=33) served as a control group. The animals in GI, GII, and Gill were given a PGF(2 alpha) analogue on days 15 and 26 pp. Each group was further divided into subgroups of normal parturition (np) and dystocia (d) when the study results were evaluated. It was found that the first service pregnancy rates for the subgroup of dystocia were significantly higher (P0.05). As the treatment with CHR-OXT combined with PGF(2 alpha) on days 15 and 26 was associated to improved uterine involution patterns and reproductive performance, our results suggest that administration of this preventive treatment would be useful, especially for cases of dystocia.

Purpose: To inform healthy women about breast cancer and screen them, as well as to look for any relationship between demographic and clinical findings and breast cancer

43rd Annual Conference of Physiology and Pathology of Reproduction/35th Mutual Conference on Veterinary and Human Reproductive Medicine -- FEB 24-26, 2010 -- Munich, GERMANY Guvenc, Tolga/0000-0003-1468-3415; Kucukaslan, Ibrahim/0000-0002-3458-4409; FINDIK, Murat/0000-0003-1408-2548 WOS: 000273688500041 …