1. Multitargeting the Action of 5-HT
- Author
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Kinga, Czarnota-Łydka, Katarzyna, Kucwaj-Brysz, Patryk, Pyka, Wawrzyniec, Haberek, Sabina, Podlewska, and Jadwiga, Handzlik
- Subjects
Serotonin ,Alzheimer Disease ,Receptors, Serotonin ,Animals ,Humans ,Serotonin Antagonists ,Cognition Disorders ,Ligands - Abstract
In view of the unsatisfactory treatment of cognitive disorders, in particular Alzheimer's disease (AD), the aim of this review was to perform a computer-aided analysis of the state of the art that will help in the search for innovative polypharmacology-based therapeutic approaches to fight against AD. Apart from 20-year unrenewed cholinesterase- or NMDA-based AD therapy, the hope of effectively treating Alzheimer's disease has been placed on serotonin 5-HT
- Published
- 2022