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Your search keyword '"Kang, Chantal"' showing total 2 results
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2 results on '"Kang, Chantal"'

1. Synchronized Pulsatile Flow With Low Systolic Output From Veno-Arterial Extracorporeal Membrane Oxygenation Improves Myocardial Recovery After Experimental Cardiac Arrest in Pigs

Author

Voicu, Sébastian, Sideris, Georgios, Dillinger, Jean-Guillaume, Yannopoulos, Demetris, Deye, Nicolas, Kang, Chantal, Bonneau, Michel, Bartos, Jason, Kedra, Antoni, Bailliart, Sophie, Pasteur-Rousseau, Adrien, Amah, Guy, Bonnin, Philippe, Callebert, Jacques, Henry, Patrick, Mégarbane, Bruno, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS)-Harvard Medical School [Boston] (HMS), Centre de Recherche en Imagerie Interventionnelle Radiologie, Partenaires INRAE, and École de biologie industrielle (EBI)

Subjects
Left ventricular ejection fraction, Swine, [SDV]Life Sciences [q-bio], Heart Ventricles, Hemodynamics, Heart, Cardiac arrest, Heart Arrest, Extracorporeal Membrane Oxygenation, Pulsatile Flow, Synchronized pulsatile flow, Animals, Female, Pulmonary capillary pressure
Abstract

International audience; Circulatory failure following cardiac arrest (CA) requires catecholamine support and occasionally veno-arterial extracorporeal membrane oxygenation (vaECMO). VaECMO-generated blood flow is continuous and retrograde, increasing ventricular stroke work. Our aim was to assess the benefit of a device generating a pulsatile vaECMO flow synchronized with the heart rhythm lowering systolic vaECMO output on the left ventricular ejection fraction (LVEF) and pulmonary capillary pressure (Pcap) after CA. This experimental randomized study in pigs compared standard nonpulsatile vaECMO (control) with pulsatile synchronized vaECMO (study) group using a pulsatility-generating device. After sedation and intubation, ventricular fibrillation was induced by pacing. After 10-min ventricular fibrillation, cardiopulmonary resuscitation was performed for 20 min then vaECMO, defibrillation and 0.15 mu g/kg/min intravenous epinephrine infusion were initiated. Hemodynamics, Pcap, LVEF by echocardiography and angiography were measured at baseline and every 30 min after the vaECMO start until vaECMO and epinephrine were stopped (at 120 min), and 30 min later. Baseline hemodynamics did not differ between groups; 120 min after vaECMO initiation, LVEF by echocardiography and angiography was significantly higher in the study than control group 55 +/- 19% versus 34 +/- 13% (P=0.042), 50 +/- 16% versus 33 +/- 12% (P=0.043), respectively. Pcap decreased from baseline by 4.2 +/- 8.6 mm Hg in the study group but increased by 5.6 +/- 5.9 mm Hg in the control group (P=0.043). Thirty minutes later, LVEF remained higher in the study group 44 +/- 7% versus 26 +/- 11% (P=0.008) while Pcap did not differ. A synchronized pulsatile device decreasing systolic output from vaECMO improved LVEF and Pcap in a pig model of CA and resuscitation.

Published
2017

2. ENDOCOM: Implantable wireless pressure sensor for the follow-up of abdominal aortic aneurysm stented

Author

Romain, Olivier, Mazeyrat, Johan, Garda, Patrick, Talleb, Hakeim, Lautru, David, Wong, Man-Faï, Wiart, Joe, Fouad Hanna, Victor, Lagrée, Pierre-Yves, Bonneau, Michel, Kang, Chantal, Fernández, Miguel Angel, Gerbeau, Jean-Frédéric, Deplano, Valérie, Legallais, Cécile, Leprince, Pascal, Systèmes Electroniques (SYEL), Laboratoire d'Informatique de Paris 6 (LIP6), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique et Electromagnétisme (L2E), Université Pierre et Marie Curie - Paris 6 (UPMC), Orange Labs [Issy les Moulineaux], France Télécom, Institut Jean Le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Imagerie Interventionnelle (CR2I), Institut National de la Recherche Agronomique (INRA), Numerical simulation of biological flows (REO), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Inria Paris-Rocquencourt, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Université de Technologie de Compiègne (UTC), Service de neuro-radiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut Jean le Rond d'Alembert (DALEMBERT), Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
medicine.medical_specialty, medicine.medical_treatment, Biomedical Engineering, Biophysics, 030204 cardiovascular system & hematology, 030230 surgery, Network configuration, In vivo tests, RFID pressure sensor, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, medicine, In vivo experiments, cardiovascular diseases, Thrombus, Endovascular treatment, AAA, Aorta, business.industry, Stent, medicine.disease, Pressure sensor, Abdominal aortic aneurysm, 3. Good health, Surgery, [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, Numerical modelling, cardiovascular system, Radiology, business
Abstract

International audience; An abdominal aortic aneurysm (AAA) is a dilatation of the aorta at the abdominal level, the rupture of which is a life threatening complication with an 80% mortality rate. Even though those devices keep improving, the failure rate of the endovascular treatment is due to persisting pressure into the excluded aneurysmal sac. Since 2005, several integrated sensors have been designed for the follow-up of the AAA treated by a stent. Solutions are based on the use of a single sensor. Thrombus in the excluded AAA can modify the field of pressure when leaks appeared and a network of sensors should be used. We present in this paper the ENDOCOM project that aims to design an implantable pressure sensor that can be used in a network configuration. To validate the new materials, we developed a framework composed of in vitro experiments and in vivo tests on large animal model. Numerical modeling has been investigated from the experimental data to determine the optimal position of sensor. Some results of those different parts are shown in this paper.

Published
2011

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