1. Morbidity, mortality and long-term sequelae of West Nile virus disease in Québec
- Author
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Kairy D, Tannenbaum Tn, Lowe Am, Vibien A, Fortin A, Ouhoumanne N, Milord F, and K-Lensch J
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Epidemiology ,030231 tropical medicine ,Disease ,Severity of Illness Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Severity of illness ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Young adult ,Aged ,Aged, 80 and over ,Original Paper ,business.industry ,Medical record ,Public health ,Quebec ,Middle Aged ,medicine.disease ,Mental health ,Infectious Diseases ,Female ,Morbidity ,business ,West Nile virus ,Meningitis ,West Nile Fever ,Encephalitis - Abstract
We aimed to describe the clinical characteristics of West Nile patients reported in Québec in 2012 and 2013 and to document physical, mental and functional status 24 months after symptom onset according to illness severity. The cases were recruited by a public health professional. Data were collected from public health files, medical records and two standardised phone questionnaires: the Short Form-36 and the Instrumental Activities of Daily Living. In all, 92 persons participated in the study (25 had West Nile fever (WNF), 18 had meningitis and 49 had encephalitis). Encephalitis participants were older, had more underlying medical conditions, more neurological symptoms, worse hospital course and higher lethality than meningitis or WNF participants. Nearly half of the surviving hospitalised encephalitis patients required extra support upon discharge. At 24-month follow-up, encephalitis and meningitis patients had a lower score in two domains of the mental component: mental health and social functioning (P = 0.0025 and 0.0297, respectively) compared with the norms based on age- and sex-matched Canadians. Physical status was not affected by West Nile virus (WNV) infection. In addition, 5/36 (15%) of encephalitis, 1/17 (6%) of meningitis and 1/23 (5%) of WNF participants had new functional limitations 24 months after symptom onset. In summary, mental and functional sequelae in encephalitis patients are likely to represent a source of long-term morbidity. Preventive measures should target patients at higher risk of severe illness after WNV infection.
- Published
- 2018
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