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Additional file 9: Supplemental Table 4. Univariate Analysis in MSI-high Gastric Carcinomas (n = 53) (corresponding to Fig. 4d & e)

Additional file 6: Supplemental Table 1. Correlation Between PD-L1 Expression and Tumor-Infiltrating Lymphocytes (TILs) in the Entire Cohort (N = 514)

Additional file 8: Supplemental Table 3. Univariate and Multivariate Analyses in EBV-positive Gastric Carcinomas (n = 32) (corresponding to Fig. 4a & c)

Additional file 7: Supplemental Table 2. Univariate and Multivariate Analyses in the Entire Cohort (N = 514) (corresponding to Fig. 2a, b & e)

Additional file 10: Supplemental Table 5. Comparison of Clinicopathologic Characteristics, and Statuses of PD-L1, FOXP3+, and PD-1+ According to the Density of CD8+ TILs in the Entire Cohort (N = 514)

Autoimmune manifestations (AIMs) are common in patients with myelodysplastic syndrome (MDS). This study aimed to investigate whether AIMs are associated with a specific cytogenetic abnormalities and worse survival in patients with MDS. A total of 67 MDS patients with AIMs and 134 age- and sex-matched MDS patients without AIMs, all of whom received medical care at Seoul National University Hospital from January 2000 through July 2014, were enrolled. The clinical features, chromosomal abnormalities, and outcomes were examined. The effect of AIMs on mortality was estimated after adjusting for age, sex, and the International Prognostic Scoring System. The mean age (±SD) at the time of MDS diagnosis was 54.5 ± 17.1 years, and 44.8% of patients were male. Neutrophilic dermatosis (ND; Sweet syndrome and pyoderma gangrenosum) was the most prevalent AIM (n = 24 36%]), followed by Behcet disease (10 [15%]), rheumatoid arthritis (9 [13%]), vasculitis (8 [12%]), myositis (3 [4%]), spondyloarthropathy (3 [4%]), and systemic lupus erythematous (2 [3%]). ND and vasculitis occurred at the time of MDS diagnosis, whereas other AIMs occurred years after MDS diagnosis. Deletion of 5q was associated with ND (P = 0.001), whereas trisomy 8 was associated with Behcet disease (P = 0.015). Strikingly, ND was associated with a 1.8-fold increase in mortality (95% CI 1.033–3.093; P = 0.038). Certain AIMs in MDS patients are associated with distinctive karyotypes and worse survival. A larger study is needed to confirm whether the presence of AIMs influences disease outcome in MDS.