1. Loss of KLF10 expression does not affect the passive properties of single myofibrils
- Author
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Pouletaut, Philippe, Li, M, Kammoun, M, Subramaniam, M, Hawse, J.R., Joumaa, V, Herzog, W, Bensamoun, S, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Human Performance, University of Calgary, Department of Biochemistry and Molecular Biology [Rochester, MI, USA], and SU-19-3-EMRG-12 funded by Idex Sorbonne University
- Subjects
Passive tension ,EDL muscle ,animal structures ,Soleus muscle ,[SDV.BA]Life Sciences [q-bio]/Animal biology ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,musculoskeletal system ,tissues ,Titin isoforms - Abstract
International audience; The purpose of this study was to gain insight into the origin of the passive behavior observed in KLF10 KO soleus and EDL muscles, at the fiber scale and at the myofibril (titin) scale. The conclusion from the results of this study is that the observed fibre-type specific changes in passive force in KLF10 KO mice muscles are not caused by sarcomere intrinsic structures but must originate outside the sarcomeres, likely in the collagen-based extracellular matrix.
- Published
- 2021