1. Synthesis of Cinacalcet congeners
- Author
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Jorge Briones, Benxin Zhi, Tony Q. Yan, John Ng, Xin Wang, Ying Chen, Carlos Orihuela, and Richard D. Crockett
- Subjects
chemistry.chemical_classification ,Chiral column chromatography ,Cinacalcet ,Double bond ,chemistry ,Organic Chemistry ,Drug Discovery ,Enantioselective synthesis ,medicine ,Organic chemistry ,Biochemistry ,medicine.drug - Abstract
Two racemic isomeric dihydronaphthalenes 1 and 2 were prepared from commercially available 5-hydroxytetralone in five linear steps. A key palladium-catalyzed double bond migration led to the synthesis of both isomers from the same starting material. Preparative chiral HPLC separation provided the enantiomerically pure materials. An asymmetric synthesis employing CBS reduction to furnish 1 was also developed.
- Published
- 2004
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