1. Surgical Pain Control With Ropivacaine by Atomized Delivery (Spray): A Randomized Controlled Trial
- Author
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Gretchen G. Collins, Sarah A Wagner, Elizabeth R. Mueller, Steven B. Edelstein, Jill A. Gadzinski, Jordan Sheran, and Garrett Fitzgerald
- Subjects
Adult ,medicine.medical_specialty ,Visual analogue scale ,medicine.medical_treatment ,law.invention ,03 medical and health sciences ,Gynecologic Surgical Procedures ,0302 clinical medicine ,Patient satisfaction ,Double-Blind Method ,Pneumoperitoneum ,Randomized controlled trial ,law ,Statistical significance ,Humans ,Medicine ,Ropivacaine ,030212 general & internal medicine ,Anesthetics, Local ,Saline ,Pain Measurement ,Pain, Postoperative ,030219 obstetrics & reproductive medicine ,Hysterectomy ,business.industry ,Nebulizers and Vaporizers ,Obstetrics and Gynecology ,Insufflation ,Middle Aged ,medicine.disease ,Amides ,Surgery ,Treatment Outcome ,Patient Satisfaction ,Anesthesia ,Female ,business ,Injections, Intraperitoneal ,medicine.drug - Abstract
Study Objective To investigate the role of intraoperative atomized intraperitoneal ropivacaine (AIR) as an adjuvant to anesthetic agents at the time of minimally invasive pelvic surgery. Design Double-blind, randomized controlled trial. Design Classification: Randomized controlled trial (Canadian Task Force classification I). Setting Tertiary care teaching hospital. Participants Fifty-five patients who underwent laparoscopic and robotic gynecologic procedures. Intervention Patients received AIR or atomized intraperitoneal saline (AIS) (dose, 2 mg/kg) immediately after the initiation of pneumoperitoneum. Measurements and Main Results Visual analog scale (VAS) pain scores and narcotic use (in morphine equivalents) were collected and recorded at 2, 4, 8, and 12 hours postoperatively. Results Fifty-five patients completed the study protocol and data collection, with 30 patients allocated to the AIS group and 25 patients allocated to the AIR group. Demographic and surgical variables did not vary between the groups, with the exception of median operative duration. Postoperative VAS scores at 2, 4, 8, and 12 postoperative hours were higher in the AIS group, but the difference failed to reach statistical significance. Narcotic use was also similar in the 2 groups. Conclusion The use of intraperitoneal ropivacaine was not associated with a statistically significant difference in patients' postoperative VAS scores. Thus, in contrast to findings of similar studies performed in general surgery, AIR might not confer a benefit in women undergoing minimally invasive gynecologic procedures.
- Published
- 2016
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