1. Glomerular C4d Deposition and Kidney Disease Progression in IgA Nephropathy: A Systematic Review and Meta-analysis
- Author
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Jicheng Lv, Xuhui Zhong, Wanyin Hou, Sufang Shi, Xu-jie Zhou, Jincan Zan, Yuanyuan Jiang, Wenjing Zhao, and Hong Zhang
- Subjects
medicine.medical_specialty ,prevalence ,Population ,Urology ,Renal function ,urologic and male genital diseases ,Nephropathy ,Internal Medicine ,medicine ,education ,Original Research ,education.field_of_study ,Kidney ,urogenital system ,business.industry ,IgA nephropathy ,medicine.disease ,meta-analysis ,medicine.anatomical_structure ,Nephrology ,Meta-analysis ,C4d deposition ,Biomarker (medicine) ,prognosis ,business ,Cohort study ,Kidney disease - Abstract
Background Glomerular deposition of C4d is a widely used biomarker for activation of the lectin pathway in the complement system and is reported to be associated with kidney progression in immunoglobulin A nephropathy (IgAN). The aim of this study was to evaluate whether glomerular C4d deposition, as a new biomarker, improves the prediction of kidney prognosis in IgAN. Study Design Systematic review and meta-analysis. Setting & Population Patients with biopsy-proven primary IgAN without age limitations. Selection Criteria for Studies: Cross-sectional or cohort studies reporting the prevalence of glomerular C4d deposition or evaluating its association with IgAN progression. Predictor Glomerular C4d deposition. Outcome Composite progression event of a >30% decline in estimated glomerular filtration rate or end-stage kidney disease. Results 12 studies with 1,251 patients were included. The prevalence of glomerular C4d deposition was 34% (95% CI, 27%-41%), with large heterogeneity (I2 = 86%; P
- Published
- 2021
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