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Tik Tok, also known as Dou Yin in its Chinese version, has had a growing reputation in the social networking world since its launching in September 2016. While there are numerous content categories on Tik Tok that attract the many views and likes, beauty and skincare are within the top ten most popular content attracting billions of views. In what used-to-be female influencers dominated field, we witnessed the substantial growth of male makeup influencers with a proportion of them successfully integrated into the worldwide beauty market with high reputation and fame. The objective of this study is to analyze the differences between American and Chinese male makeup influencers as a means to reflect how they differ in aesthetic preference and social factors when creating beauty-related contents. This study employed a mixed-method with both content analyses of the Tik Tok posts as well as a structured scoring system for the appearance of the influencers. The results of the scoring are 7.1 for U.S. influencers and 7.2 for Chinese influencers. Both countries have a very similar feminine appearance with Chinese influencers resulting a slight higher scoring than U.S. influencers. The conclusion of this study rests on the fact that both American and Chinese influencers are emerging in this arena with their own definition of beauty using makeup and other beauty-related products; though they exemplified certain differences in aesthetics preference of appearance, they demonstrated a beauty revolution that is unseen before through social media which aim to challenge how the society perceive beauty and gender presentation.

Plant fructokinase (FRK) guarantees the growth and development of higher plants by participating in carbohydrate metabolism. In this study, a new fructokinase, OsFRK3, was identified using bioinformatics analysis, enzyme assay, bacterial growth assay, and yeast complementation test. Then, we created

A viable pathway towards achieving shared prosperity is made possible by the growth of tourism, which encourages the movement of urban and rural elements. This harmonious alignment of tourism development and urban–rural integration also helps to narrow the gap between urban and rural areas. This study uses a set of panel regression models to investigate whether tourism growth promotes urban–rural integration within 41 cities in the Yangtze River Delta Region of China from 2010 to 2020. The findings show that the effect of tourism development on urban–rural integration is significantly positive, displaying significant heterogeneity across various times and city sizes. Furthermore, tourism development exhibits a threshold effect and city-type heterogeneity concerning urban–rural integration. The effect demonstrates significant continuous growth along with the expansion of economic growth. However, the impact of tourism development on urban–rural integration demonstrates a distinct promotional threshold effect, and its positive effect appears to be weakened.

To explore the structural characteristics and further utilize the semi-cokes obtained from a self-designed pilot-scale entrained flow gasifier at the temperatures of 800–1200 °C with oxygen-enriched air as gasifying agents (21, 50, and 100% O2 in N2), the gasified semi-cokes were characterized by N2 adsorption, scanning electron microscopy (SEM), and X-ray diffraction (XRD) methods, and their combustion performances and kinetic analysis were explored using a thermogravimetric analyzer. Results indicated that the volatile release was significantly enhanced with rising gasification temperature, which would contribute to the rapid development of pore structure in semi-cokes. The increasing oxygen concentration mainly worked on promoting both the volatile release and the carbon conversion through enhancing the oxidation reactions with carbon matrix, which would result in the dramatic decrease of both surface area and micropore volume. Thermal analysis showed that the ignition and comprehensive combustion performances of semi-cokes got worse as the gasification temperature and oxygen concentration increased, indicating that the volatile matter is vitally important to promote the ignition as well as maintain the combustion stability. While their combustion intensity and burnout index were more dependent on the pore structure. The activation energy of semi-cokes calculated by both FWO and KAS methods increased with the temperature and oxygen concentration, and different order reaction models (ranged from 0.8 to 2.1) were responsible for the combustion of semi-cokes. It is notable that the volatile content and pore structure are the key factors affecting the variation of activation energy with conversion degree and the magnitude of the reaction kinetic model.

Despite the recognition of the correlation between the tourism industry and a town’s spatial morphology, there is a dearth of rigorous empirical specifications to examine it. This study uses geographic information system (GIS) tools and space syntax analysis to explore whether the tourist hotel industry and a town’s spatial morphology are consistent or if they have different spatial distributions. From a sample of Phoenix Ancient Town, China, our analysis shows the following results: First, there is a spatial correlation between the tourist hotel industry and urban spatial morphology, which is significantly related to tourist attraction distribution and traffic accessibility. Second, the spatial evolution of the tourist hotel industry and a town’s spatial morphology shows different characteristics in different periods. Third, the impact of the tourist hotel industry on a town’s spatial morphology is gradually decreasing as new business buildings arise. The analysis is theoretically important as it enriches the methodologies for analyzing the correlation between the tourist hotel industry and a town’s spatial morphology. It is important for government planners as it provides useful information for formulating territorial spatial planning.

This article proposes a robust method for analysing longitudinal continuous responses with informative dropouts and potential outliers by using the multivariate t-distribution. We specify a dropout mechanism and a missing covariate distribution and incorporate them into the complete data log-likelihood. Unlike the existing approaches which mainly focus on the inference of regression mean and dropouts process, our approach aims to reveal the dynamics in the location function, marginal scale function and association by joint parsimonious modeling the location and dependence structure. A parametric fractional imputation algorithm is developed to speed up the computation associated with the EM algorithm for maximum likelihood estimation with missing data. The resulting estimators are shown to be consistent and asymptotically normally distributed. Data examples and simulations demonstrate the effectiveness of the proposed approach.

Objective. Over the past years, convolutional neural networks based methods have dominated the field of medical image segmentation. But the main drawback of these methods is that they have difficulty representing long-range dependencies. Recently, the Transformer has demonstrated super performance in computer vision and has also been successfully applied to medical image segmentation because of the self-attention mechanism and long-range dependencies encoding on images. To the best of our knowledge, only a few works focus on cross-modalities of image segmentation using the Transformer. Hence, the main objective of this study was to design, propose and validate a deep learning method to extend the application of Transformer to multi-modality medical image segmentation. Approach. This paper proposes a novel automated multi-modal Transformer network termed AMTNet for 3D medical image segmentation. Especially, the network is a well-modeled U-shaped network architecture where many effective and significant changes have been made in the feature encoding, fusion, and decoding parts. The encoding part comprises 3D embedding, 3D multi-modal Transformer, and 3D Co-learn down-sampling blocks. Symmetrically, the 3D Transformer block, upsampling block, and 3D-expanding blocks are included in the decoding part. In addition, a Transformer-based adaptive channel interleaved Transformer feature fusion module is designed to fully fuse features of different modalities. Main results. We provide a comprehensive experimental analysis of the Prostate and BraTS2021 datasets. The results show that our method achieves an average DSC of 0.907 and 0.851 (0.734 for ET, 0.895 for TC, and 0.924 for WT) on these two datasets, respectively. These values show that AMTNet yielded significant improvements over the state-of-the-art segmentation networks. Significance. The proposed 3D segmentation network exploits complementary features of different modalities during the feature extraction process at multiple scales to increase the 3D feature representations and improve the segmentation efficiency. This powerful network enriches the research of the Transformer to multi-modal medical image segmentation.

In this study, the co-combustion characteristics of coal and biomass blends (20, 40, 60, 80, and 100 wt%) were investigated by thermogravimetric analysis. All the samples were operated under an oxidative atmosphere, with a heating rate of 20 C/min. The reaction stages, ignition and burnout temperature, maximum weight loss rate, and different combustion indices were determined. When the percentage of biomass in the blends was increased, the maximum mass loss rate was enhanced in the second region, and the ignition and burnout temperature was lowered, indicating the higher reactivity and better combustion performance of the samples. The comprehensive performance index presented an N shape with the increasing biomass blending ratio. Based on various combustion indices, 20% was an optimum percentage for the co-utilization of coal-biomass blends. A significant promoting interaction was observed between corn straw and rice straw blends, while inhibiting effects occurred between rice husk and coal. The kinetic parameters of the blends were evaluated by the Coats and Redfern method using the nth-order reaction model. The value of activation energy and the pre-exponential factor increased with the decreasing biomass percentage in the blends.

The comparative effects of five metal chlorides (KCl, CaCl2, NiCl2, MnCl2, and ZnCl2) on the catalytic pyrolysis, especially the volatile gas release characteristics of lignite over a high-temperat...

MicroRNAs (miRNAs) are increasingly recognized as being involved in pancreatic cancer progression by directly regulating the expression of their targets. In this study, we showed that miR-216b-5p expression was significantly decreased in pancreatic cancer tissues and cell lines. In addition, low miR-216b-5p expression was significantly associated with large tumor size and advanced TNM stage. Meanwhile, both Kaplan-Meier and multivariate survival analysis showed that decreased miR-216b-5p expression was associated with overall survival. miR-216b-5p over-expression repressed pancreatic cancer cell proliferation and induced cell cycle arrest and cell apoptosis in vitro and inhibited tumorigenesis in vivo. The translationally controlled tumor protein (TPT1) was identified as a novel direct target of miR-216b-5p. miR-216b-5p up-regulation suppressed TPT1 expression. Moreover, TPT1 mRNA expression levels were increased in pancreatic cancer tissues, and were inversely correlated with miR-216b-5p expression. TPT1 down-regulation had similar effects as miR-216b-5p up-regulation on pancreatic cancer cell progression. The restoration of TPT1 reversed the effect of miR-216b-5p on pancreatic cancer cell progression. Furthermore, we found that miR-216b-5p up-regulation suppressed Pim-3, Cyclin B1, p-Bad and Bcl-xL protein expression. However, the effect of miR-216b-5p up-regulation was partly reversed by TPT1 up-regulation in vitro. Taken together, our findings suggested that miR-216b-5p functions as a potential tumor suppressor by regulating TPT1 in pancreatic cancer cells, and it may represent a potential therapeutic target for patients with pancreatic cancer.

// Yu You 1 , Jia-Xin Tan 1 , Hai-Su Dai 1 , Hao-Wei Chen 1 , Xue-Jun Xu 1 , Ai-Gang Yang 1 , Yu-Jun Zhang 1 , Lian-Hua Bai 1 , Ping Bie 1 1 Department of Hepatobiliary Surgery Institute, South Western Hospital, Third Military Medical University, Chongqing 400038, China Correspondence to: Ping Bie, email: bieping@medmail.com.cn Lian-Hua Bai, email: 870426131@qq.com Keywords: hepatocellular carcinoma, hepatic stellate cells, galectin-1, miRNA-22 Received: April 14, 2016 Accepted: July 10, 2016 Published: August 1, 2016 ABSTRACT Hepatic stellate cells (HSCs) induce immune privilege and promote hepatocellular carcinoma (HCC) by suppressing the immune system. On the other hand, galectin-1 and miRNA-22 (miR-22) are dysregulated in HCC and serve as prognostic indicators for patients. In this study, therefore, we measured galectin-1 and miR-22 expression in HSCs isolated from HCC tissues (Ca-HSCs), and in normal liver tissues (N-HSCs) as a control. We also investigated the apoptosis rate among T cells and the production of cytokines (IFN-γ and IL-10) in HSCs co-cultured with T cells. And we used immunohistochemical staining to tested for correlation between galectin-1 expression, CD3 expression and clinicopathological features in 162 HCC patients. Our results showed that galectin-1 expression was much higher in Ca-HSCs than in N-HSCs. Overexpression of galectin-1 promoted HSC-induced T cell apoptosis and cytokine production (IFN-γ and IL-10), while miR-22 expression inhibited it. Galectin-1 expression correlated negatively with miR-22 expression in HSCs. High galectin-1 and low CD3 expression levels were associated with poor prognosis in HCC patients. These results suggest that the immunosuppressive microenvironment promoted by HSC-derived galectin-1 in HCC can be inhibited by miR-22. Galectin-1 and miR-22 could potentially serve as prognostic markers and therapeutic targets in HCC.

The gasification experiments of coal chars with CO2 were carried out isothermally, with K, Ca, Ni, and Zn chloride catalysts, adopting a thermal gravimetric analyzer (TGA) from 800 to 1100 &deg, C. The kinetic characteristic of the samples were described using the volumetric model (VM), the grain model (GM), and the random pore model (PRM). The morphology patterns of the samples were tested applying X-ray diffraction (XRD) and the catalytic mechanisms concerning the phase changes were proposed. The results confirm that the gasification rate and char reactivities are enhanced by K, Ca and Ni chlorides, while ZnCl2 inhibited the process. The catalysis ability shows the following cation order: Ca &gt, K &gt, Ni &gt, Zn. Among the models described above, PRM was proven to give the best fitting value and hence adopted to kinetics parameters calculation. The activation energies in promoting conditions were lower than that of the uncatalyzed cases. In view of the catalytic mechanism, the K metals tend to form intermediate complexes and repeatedly connect with coal char, while the Ca species may follow the oxidation-reduction mechanism and the Ni metals catalyze the gasification process.

The plant hormone auxin plays pivotal roles in many aspects of plant growth and development. The auxin/indole-3-acetic acid (Aux/IAA) gene family encodes short-lived nuclear proteins acting on auxin perception and signaling, but the evolutionary history of this gene family remains to be elucidated. In this study, the Aux/IAA gene family in 17 plant species covering all major lineages of plants is identified and analyzed by using multiple bioinformatics methods. A total of 434 Aux/IAA genes was found among these plant species, and the gene copy number ranges from three (Physcomitrella patens) to 63 (Glycine max). The phylogenetic analysis shows that the canonical Aux/IAA proteins can be generally divided into five major clades, and the origin of Aux/IAA proteins could be traced back to the common ancestor of land plants and green algae. Many truncated Aux/IAA proteins were found, and some of these truncated Aux/IAA proteins may be generated from the C-terminal truncation of auxin response factor (ARF) proteins. Our results indicate that tandem and segmental duplications play dominant roles for the expansion of the Aux/IAA gene family mainly under purifying selection. The putative nuclear localization signals (NLSs) in Aux/IAA proteins are conservative, and two kinds of new primordial bipartite NLSs in P. patens and Selaginella moellendorffii were discovered. Our findings not only give insights into the origin and expansion of the Aux/IAA gene family, but also provide a basis for understanding their functions during the course of evolution.

The Chinese water bureaucracy increasingly utilises information and communications technology (ICT) in order to strengthen interaction with the population, which is severely affected by industrial pollution. Government webpages, mailboxes, and online interviews with officers have become prevalent tools for environmental governance, including information disclosure, and a virtual communication forum between the state and its citizens. The present study employs a mixed methods approach with a qualitative emphasis to explore the process of communication and interaction between government agencies and local residents in Dongying, Shandong Province. The results show that information disclosure of pollution data remains far from being transparent, despite the fact that the local government has implemented digital environmental governance, as encouraged by the central Chinese state. Internet technologies empower resource-poor environmental activists in Dongying to strengthen their social network and build communication with the authorities. The application of bureaucratic techniques, however, is key for them to enter the communication interface with government agencies in order to influence political decisions. Results suggest that local cadres tend to send mixed signals to activists and display wariness towards them. They also tend to take preventive measures to keep the situation under control when environmental disputes arise. The proposed communication interface approach sheds a clearer light on the complexity among the emergent ICTs, environmental activism, and digital governance.

The plant hormone auxin plays pivotal roles in many aspects of plant growth and development. The auxin/indole-3-acetic acid (Aux/IAA) gene family encodes short-lived nuclear proteins acting on auxin perception and signaling, but the evolutionary history of this gene family remains to be elucidated. In this study, the Aux/IAA gene family in 17 plant species covering all major lineages of plants is identified and analyzed by using multiple bioinformatics methods. A total of 434 Aux/IAA genes was found among these plant species, and the gene copy number ranges from three (Physcomitrella patens) to 63 (Glycine max). The phylogenetic analysis shows that the canonical Aux/IAA proteins can be generally divided into five major clades, and the origin of Aux/IAA proteins could be traced back to the common ancestor of land plants and green algae. Many truncated Aux/IAA proteins were found, and some of these truncated Aux/IAA proteins may be generated from the C-terminal truncation of auxin response factor (ARF) proteins. Our results indicate that tandem and segmental duplications play dominant roles for the expansion of the Aux/IAA gene family mainly under purifying selection. The putative nuclear localization signals (NLSs) in Aux/IAA proteins are conservative, and two kinds of new primordial bipartite NLSs in P. patens and Selaginella moellendorffii were discovered. Our findings not only give insights into the origin and expansion of the Aux/IAA gene family, but also provide a basis for understanding their functions during the course of evolution.

Cisplatin (CDDP) efficiency in pancreatic cancer therapy is limited due to development of drug resistance. However, the comprehensive mechanisms remain largely unclear. In this study, we first established a CDDP-resistant pancreatic cancer cell line-BXPC-3/CDDP from its parental cell line-BXPC-3. The results showed that CDDP resistance in BXPC-3/CDDP cells correlates with changes in cellular EMT phenotypes. Prostate apoptosis response-4 (Par-4) expression at both mRNA and protein levels were reduced in CDDP-resistant BXPC-3/CDDP cells compared with that in BXPC-3 cells. Ectopic expression of Par-4 reversed EMT and CDDP resistance in BXPC-3/CDDP cells. In BXPC-3 cells, knockdown of Par-4 expression induces EMT and CDDP insensitivity, however, these effects were blocked by inhibition of PI3K/Akt pathway using LY294002. Furthermore, Par-4 knockdown could significantly stimulate PI3K/Akt signaling in BXPC-3 cells. In vivo studies, xenograft BXPC-3 tumors were sensitive to CDDP treatment. Treatment with CDDP alone had little effect on the growth of Par-4 siRNA-transfected BXPC-3 tumors in nude mice and the survival rate compared with control. Inhibition of PI3K/Akt pathway using LY294002 reversed CDDP resistance in Par-4 siRNA-transfected BXPC-3 tumors. In conclusion, these results indicate that Par-4 downregulation confers CDDP resistance via PI3K/Akt pathway-dependent EMT in BXPC-3 cells. Therefore, Par-4 may be a potential target for overcoming CDDP resistance in pancreatic cancer.

Raf kinase inhibitor protein (RKIP) is a tumor suppressor that inhibits cell growth and metastasis of malignant tumors. Pancreatic cancer is a leading cause of cancer death with a low survival rate. RKIP expression and its role in tumorigenesis and metastasis in pancreatic cancer are poorly understood. The aims of our study were to assess the effects of RKIP on pancreatic carcinoma cells in vitro and in tumor tissues in vivo. This study included 84 patients with histologically confirmed pancreatic adenocarcinoma. The expression levels of RKIP were measured in pancreatic cancer tissues and adjacent normal tissues using real-time PCR and immunohistochemistry. Overexpression plasmid of RKIP was transfected into SW1990 and AsPC-1 cell lines, and the effects on cell proliferation were studied using a Cell Counting Kit-8 assay. MEK1/2 and ERK1/2 were detected by Western blot and immunofluorescence assay. Results showed a reduced expression of RKIP in pancreatic carcinoma tissues compared with adjacent normal tissues, which closely correlated with patient outcomes. Overexpression of RKIP suppressed cell proliferation and promoted apoptosis in cultured SW1990 and AsPC-1 cell lines. Transwell assay showed RKIP can inhibit cell migration and invasion, and in vivo RKIP can suppress tumorigenesis by diminishing the volume of the tumors. In conclusion, expression of RKIP is closely correlated with the survival of pancreatic cancer patients. RKIP can inhibit pancreatic adenocarcinoma cells proliferation, activities of migration and invasion, through downregulating Raf-1-MEK1/2-ERK1/2 signaling pathway.

"The Sanjiangyuan region is located on the Qinghai-Tibetan Plateau in western China and encompasses the headwaters of the Yangtze, Yellow and Mekong rivers. It is also home to 300,000 Tibetan pastoralists. The area is characterized by its significant ecological service, unique culture, and fragile ecosystems, and has undergone a rapid degradation over the past several decades. Traditional Tibetan culture offers alternative knowledge and perspectives that facilitate the environmental conservation throughout the region, but have yet to be recognized or adopted by the Chinese government. Beginning in 2007, the local environmental NGO, Shanshui Conservation Center, has initiated a journey to bridge Tibetan communities with the outside scientific community, mainstream society and policy-makers with the aim of advocating integrating traditional Tibetan practices in conservation actions in the Sanjiangyuan region. Through the conservation concession program initiated and facilitated by Shanshui Conservation Center in collaboration with Conservation International, the Sanjiangyuan nature reserve turned over the management of some reserve lands to local communities after a conservation agreement with clear management plans and monitoring indictors was made between the two parties. The trial and demonstration of the conservation concession program successfully led to the adoption of community-based conservation models in state level conservation policy in 2011. We demonstrate as a bridging organization, Shanshui Conservation Center plays the role of cultural translator to promote the understanding and appreciation of traditional Tibetan culture in conservation in western China."