43 results on '"Jialu He"'
Search Results
2. Did the COVID-19 pandemic impact urticaria information-seeking behavior in China? A retrospective longitudinal study
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Qinzhun Zhang, Yi Yu, Jialu He, Xinmeng Yao, Yinan He, Jinghua Wu, Chenjie Xu, and Chengyin Ye
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Public Health, Environmental and Occupational Health - Abstract
PurposeTo investigate information-seeking behavior related to urticaria before and during the COVID-19 pandemic in China.MethodsSearch query data for terms related to urticaria were retrieved using Baidu Index database from October 23, 2017 to April 23, 2022, and daily COVID-19 vaccination doses data were obtained from the website of the Chinese Center for Disease Control and Prevention. Among the 23 eligible urticaria search terms, four urticaria themes were generated as classification, symptom, etiology, and treatment of urticarial, respectively. Baidu Search Index (BSI) value for each term were extracted to analyze and compare the spatial and temporal distribution of online search behavior for urticaria before and after the COVID-19 pandemic, and to also explore the correlation between search query and daily COVID-19 vaccination doses.ResultsThe classification of urticaria accounted for nearly half of the urticaria queries on the internet. Regular seasonal patterns of BSI were observed in urticaria-related online search, by attaining its highest level in spring and summer and lowest level in winter. The BSIs of all urticaria themes significantly increased after the COVID-19 pandemic than that before the pandemic (all PConclusionsThis study used the internet as a proxy to provide evidence of public search interest and spatiotemporal characteristics of urticaria, and revealed that the search behavior of urticaria have increased significantly after the COVID-19 pandemic and COVID-19 vaccination. It is anticipated that the findings about such increase in search behavior, as well as the behavior of urticaria-related vaccine-hesitancy, will help guide public health education and policy regulation.
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- 2023
3. Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides
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Dali Wang, Qiwei Wang, Yuyan Wang, Peiru Chen, Xueguang Lu, Fei Jia, Yehui Sun, Tingyu Sun, Lei Zhang, Fangyuan Che, Jialu He, Liming Lian, Gemma Morano, Michael Shen, Mengqi Ren, Sijia S. Dong, Jean J. Zhao, and Ke Zhang
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Proto-Oncogene Proteins p21(ras) ,Mice ,Multidisciplinary ,Lung Neoplasms ,Carcinoma, Non-Small-Cell Lung ,Animals ,Humans ,Molecular Targeted Therapy ,Oligonucleotides, Antisense ,Xenograft Model Antitumor Assays ,Polyethylene Glycols - Abstract
The mutant form of the guanosine triphosphatase (GTPase) KRAS is a key driver in human tumors but remains a challenging therapeutic target, making KRAS MUT cancers a highly unmet clinical need. Here, we report a class of bottlebrush polyethylene glycol (PEG)–conjugated antisense oligonucleotides (ASOs) for potent in vivo KRAS depletion. Owing to their highly branched architecture, these molecular nanoconstructs suppress nearly all side effects associated with DNA–protein interactions and substantially enhance the pharmacological properties of the ASO, such as plasma pharmacokinetics and tumor uptake. Systemic delivery to mice bearing human non–small-cell lung carcinoma xenografts results in a significant reduction in both KRAS levels and tumor growth, and the antitumor performance well exceeds that of current popular ASO paradigms, such as chemically modified oligonucleotides and PEGylation using linear or slightly branched PEG. Importantly, these conjugates relax the requirement on the ASO chemistry, allowing unmodified, natural phosphodiester ASOs to achieve efficacy comparable to that of chemically modified ones. Both the bottlebrush polymer and its ASO conjugates appear to be safe and well tolerated in mice. Together, these data indicate that the molecular brush–ASO conjugate is a promising therapeutic platform for the treatment of KRAS -driven human cancers and warrant further preclinical and clinical development.
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- 2023
4. Increased cooperation potential and risk under suppressed strategy differentiation
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Fengyuan Yu, Jianwei Wang, Wei Chen, and Jialu He
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Statistics and Probability ,Statistical and Nonlinear Physics - Published
- 2023
5. Microfluidic bioprinting of tough hydrogel-based vascular conduits for functional blood vessels
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Di Wang, Sushila Maharjan, Xiao Kuang, Zixuan Wang, Luis S. Mille, Ming Tao, Peng Yu, Xia Cao, Liming Lian, Li Lv, Jacqueline Jialu He, Guosheng Tang, Hyunwoo Yuk, C. Keith Ozaki, Xuanhe Zhao, and Yu Shrike Zhang
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Multidisciplinary ,Tissue Engineering ,Tissue Scaffolds ,Alginates ,Microfluidics ,Printing, Three-Dimensional ,Bioprinting ,Humans ,Gelatin ,COVID-19 ,Hydrogels - Abstract
Three-dimensional (3D) bioprinting of vascular tissues that are mechanically and functionally comparable to their native counterparts is an unmet challenge. Here, we developed a tough double-network hydrogel (bio)ink for microfluidic (bio)printing of mono- and dual-layered hollow conduits to recreate vein- and artery-like tissues, respectively. The tough hydrogel consisted of energy-dissipative ionically cross-linked alginate and elastic enzyme–cross-linked gelatin. The 3D bioprinted venous and arterial conduits exhibited key functionalities of respective vessels including relevant mechanical properties, perfusability, barrier performance, expressions of specific markers, and susceptibility to severe acute respiratory syndrome coronavirus 2 pseudo-viral infection. Notably, the arterial conduits revealed physiological vasoconstriction and vasodilatation responses. We further explored the feasibility of these conduits for vascular anastomosis. Together, our study presents biofabrication of mechanically and functionally relevant vascular conduits, showcasing their potentials as vascular models for disease studies in vitro and as grafts for vascular surgeries in vivo, possibly serving broad biomedical applications in the future.
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- 2022
6. Persistence-dependent dynamic interactive environment enhances cooperation
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Jialu He, Jianwei Wang, Fengyuan Yu, Wei Chen, Wenshu Xu, and Wenhui Dai
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General Physics and Astronomy - Published
- 2023
7. Key factors affecting herbivore habitat selection in tropicalseagrass beds
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Yang Fang, YunChao Wu, JiaLu He, JinLong Li, Lijun Cui, LingLan Li, Jiang Zhijian, Songlin Liu, and Xiaoping Huang
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Herbivore ,Key factors ,Habitat ,Ecology ,Pharmacology (medical) ,Biology ,Selection (genetic algorithm) - Published
- 2021
8. Response of tropical seagrass palatability based on nutritional quality, chemical deterrents and physical defence to ammonium stress and its subsequent effect on herbivory
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Yang Fang, Zhijian Jiang, Linglan Li, Jinlong Li, Jialu He, Songlin Liu, Yunchao Wu, Lijun Cui, and Xiaoping Huang
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General Medicine ,Aquatic Science ,Oceanography ,Pollution - Abstract
Seagrass-herbivore interactions play a principal role in regulating the structure and function of coastal food webs, which were affected by nutrient enrichment. Seawater nutrient enrichment might change seagrass palatability by altering seagrass physical and chemical traits, consequently modulating herbivory patterns, but this remains elusive. In this study, the dominant tropical seagrass Thalassia hemprichii was cultured in different ammonium concentrations to examine the response of seagrass nutritional quality, deterrent secondary metabolites, and leaf toughness, as well as the subsequent effect of the changed physical (e.g., leaf toughness) and chemical traits (e.g., nitrogen content; total phenol) on the grazing activity of the herbivorous snail Cerithidea rhizophorarum. Ammonium enrichment enhanced seagrass nutritional quality and decreased physical defence. Low ammonium enrichment increased total phenol content, while high ammonium enrichment reduced it. Both low and high ammonium enrichment enhanced the grazing intensity of C. rhizophorarum on seagrass. Interestingly, nutritional quality mostly determined the herbivory preference of C. rhizophorarum on the intact seagrass having physical structure, with a chemical deterrent (total phenol) playing a secondary role. In contrast, chemical deterrent mainly determined the grazing intensity on agar seagrass food which was made artificially to exclude physical structure. This indicated that seagrass leaf physical structure might hinder phenol compounds from deterring herbivores. Overall, the results presented here demonstrate that ammonium enrichment remarkably increased seagrass palatability and subsequently induced higher susceptibility to herbivory, which might induce seagrass loss.
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- 2022
9. Promotion, Disintegration and Remediation of group cooperation under heterogeneous distribution system based on peer rating
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Jianwei Wang, Fengyuan Yu, Jialu He, Wei Chen, Wenshu Xu, Wenhui Dai, and Yuexin Ming
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General Mathematics ,Applied Mathematics ,General Physics and Astronomy ,Statistical and Nonlinear Physics - Published
- 2023
10. Using expert knowledge to identify key threats and conservation strategies for wildlife: A case study with bats in China
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Huimin Gao, Ziyang Xiang, Jialu He, Bo Luo, Weiwei Wang, Yingchun Deng, Renli Yang, Wenyu Zhou, Daying Zhou, Yunke Jiang, and Jiang Feng
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Ecology ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation - Published
- 2023
11. Micropore-Forming Gelatin Methacryloyl (GelMA) Bioink Toolbox 2.0: Designable Tunability and Adaptability for 3D Bioprinting Applications
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Sili Yi, Qiong Liu, Zeyu Luo, Jacqueline Jialu He, Hui‐Lin Ma, Wanlu Li, Di Wang, Cuiping Zhou, Carlos Ezio Garciamendez, Linxi Hou, Jin Zhang, and Yu Shrike Zhang
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Tissue Engineering ,Tissue Scaffolds ,Swine ,Bioprinting ,Hydrogels ,General Chemistry ,Biomaterials ,Printing, Three-Dimensional ,Animals ,Gelatin ,Methacrylates ,General Materials Science ,Emulsions ,Biotechnology - Abstract
It is well-known that tissue engineering scaffolds that feature highly interconnected and size-adjustable micropores are oftentimes desired to promote cellular viability, motility, and functions. Unfortunately, the ability of precise control over the microporous structures within bioinks in a cytocompatible manner for applications in 3D bioprinting is generally lacking, until a method of micropore-forming bioink based on gelatin methacryloyl (GelMA) was reported recently. This bioink took advantage of the unique aqueous two-phase emulsion (ATPE) system, where poly(ethylene oxide) (PEO) droplets are utilized as the porogen. Considering the limitations associated with this very initial demonstration, this article has furthered the understanding of the micropore-forming GelMA bioinks by conducting a systematic investigation into the additional GelMA types (porcine and fish, different methacryloyl-modification degrees) and porogen types (PEO, poly(vinyl alcohol), and dextran), as well as the effects of the porogen concentrations and molecular weights on the properties of the GelMA-based ATPE bioink system. This article exemplifies not only the significantly wider range of micropore sizes achievable and better emulsion stability, but also the improved suitability for both extrusion and digital light processing bioprinting with favorable cellular responses.
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- 2022
12. Microfluidic Coaxial Bioprinting of Hollow, Standalone, and Perfusable Vascular Conduits
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Li Lv, Di Wang, Yu Shrike Zhang, Sushila Maharjan, and Jacqueline Jialu He
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food.ingredient ,Materials science ,Microfluidics ,technology, industry, and agriculture ,Tunica intima ,Gelatin ,Electrical conduit ,medicine.anatomical_structure ,food ,parasitic diseases ,cardiovascular system ,medicine ,Coaxial ,Layer (electronics) ,Lumen (unit) ,Biomedical engineering ,Sodium alginate - Abstract
Three-dimensional bioprinting represents promising approach for fabricating standalone and perfusable vascular conduits using biocompatible materials. Here we describe a step-by-step method by using a multichannel coaxial extrusion system (MCCES) and a blend bioink constituting gelatin methacryloyl, sodium alginate, and eight-arm poly(ethylene glycol)-acrylate with a tripentaerythritol core for the fabrication of standalone circumferentially multilayered hollow tubes. This microfluidic bioprinting method allows the fabrication of perfusable vascular conduits with a core lumen, an inner endothelial layer resembling the tunica intima, and an outer smooth muscle cell layer resembling the tunica media of the blood vessel. Biocompatible and perfusable blood vessels with a widely tunable size range in terms of luminal diameters and wall thicknesses can be successfully fabricated using the MCCES.
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- 2021
13. Carbon Transfer Processes of Food Web and Trophic Pathways in a Tropical Eutrophic Seagrass Meadow
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Lijun Cui, Zhijian Jiang, Xiaoping Huang, Yunchao Wu, Songlin Liu, Qiming Chen, Jinlong Li, and Jialu He
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Science ,seagrass meadow ,carbon sources ,Ocean Engineering ,Aquatic Science ,QH1-199.5 ,Oceanography ,Food chain ,Water Science and Technology ,Trophic level ,Global and Planetary Change ,Biomass (ecology) ,biology ,Ecology ,detritus pathway ,Detritivore ,General. Including nature conservation, geographical distribution ,biology.organism_classification ,Food web ,Seagrass ,eutrophication ,Habitat ,carbon transfer process ,Environmental science ,grazing pathway ,Epiphyte - Abstract
Seagrass meadows provide important habitats and rich organic carbon sources for consumers at different trophic levels but are threatened by accelerating eutrophication in coastal waters. Nevertheless, at present, carbon transfer processes throughout the food web and trophic pathways in eutrophic seagrass meadows are still poorly known. To resolve this issue, carbon sources of different trophic communities in a eutrophic tropical seagrass meadow [Xincun (XC) bay, South China Sea] under eutrophication were examined in summer and winter using dual stable isotopes. The δ13C value of omnivores and carnivores overlapped more with that of herbivores and planktivores/filter feeders, which mainly overlapped with that of epiphytes in summer and macroalgae in winter. Meanwhile, epiphytes and macroalgae exhibited high biomass and corresponding highest contribution to herbivores, omnivores, and carnivores in summer and winter, respectively. These results suggest that the grazing food chain was the main trophic pathway in this eutrophic seagrass meadow, and that the transfer of carbon flow in the grazing food chain was mainly dominated by the proliferating epiphytes or macroalgae carbon. In contrast, the contribution of seagrass to detritivores in both seasons was higher than that of other food sources. Our findings suggest that in eutrophic tropical seagrass meadows, the proliferation of epiphytes or macroalgae induced by high nutrient loading, as well as their seasonal changes, has a greater impact on the transfer of carbon in the grazing food chain than that in the detritus food chain, and the seagrass fueled the food web mainly through the detritus food chain.
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- 2021
14. Inequal dependence on members stabilizes cooperation in spatial public goods game
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Fengyuan Yu, Jianwei Wang, and Jialu He
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General Mathematics ,Applied Mathematics ,General Physics and Astronomy ,Statistical and Nonlinear Physics - Published
- 2022
15. The slow but persistent self-improvement boosts group cooperation
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Jialu He, Jianwei Wang, Fengyuan Yu, Wei Chen, and Bofan Li
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Statistics and Probability ,Statistical and Nonlinear Physics - Published
- 2022
16. Microfluidic Coaxial Bioprinting of Hollow, Standalone, and Perfusable Vascular Conduits
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Sushila, Maharjan, Jacqueline Jialu, He, Li, Lv, Di, Wang, and Yu Shrike, Zhang
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Tissue Engineering ,Tissue Scaffolds ,Microfluidics ,Printing, Three-Dimensional ,Bioprinting ,Gelatin ,Methacrylates - Abstract
Three-dimensional bioprinting represents promising approach for fabricating standalone and perfusable vascular conduits using biocompatible materials. Here we describe a step-by-step method by using a multichannel coaxial extrusion system (MCCES) and a blend bioink constituting gelatin methacryloyl, sodium alginate, and eight-arm poly(ethylene glycol)-acrylate with a tripentaerythritol core for the fabrication of standalone circumferentially multilayered hollow tubes. This microfluidic bioprinting method allows the fabrication of perfusable vascular conduits with a core lumen, an inner endothelial layer resembling the tunica intima, and an outer smooth muscle cell layer resembling the tunica media of the blood vessel. Biocompatible and perfusable blood vessels with a widely tunable size range in terms of luminal diameters and wall thicknesses can be successfully fabricated using the MCCES.
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- 2021
17. Persistent imitation paves the way for cooperation in public goods game
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Jianwei Wang, Wenhui Dai, Jialu He, Fengyuan Yu, and Xin Shen
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General Physics and Astronomy - Published
- 2022
18. The interplay between reputation and heterogeneous investment enhances cooperation in spatial public goods game
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Jialu He, Jianwei Wang, Fengyuan Yu, Wei Chen, and Yuhao Ji
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General Physics and Astronomy - Published
- 2022
19. Sand supplementation favors tropical seagrass Thalassia hemprichii in eutrophic bay: implications for seagrass restoration and management
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Zhijian Jiang, Songlin Liu, Lijun Cui, Jialu He, Yang Fang, Chanaka Premarathne, Linglan Li, Yunchao Wu, Xiaoping Huang, and Manoj Kumar
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Flavonoids ,Bays ,Sand ,Dietary Supplements ,Plant Science ,Hydrocharitaceae ,Amino Acids ,Sulfides ,Ecosystem - Abstract
Background Sediment is crucial for the unique marine angiosperm seagrass growth and successful restoration. Sediment modification induced by eutrophication also exacerbates seagrass decline and reduces plantation and transplantation survival rates. However, we lack information regarding the influence of sediment on seagrass photosynthesis and the metabolics, especially regarding the key secondary metabolic flavone. Meanwhile, sulfation of flavonoids in seagrass may mitigate sulfide intrusion, but limited evidence is available. Results We cultured the seagrass Thalassia hemprichii under controlled laboratory conditions in three sediment types by combining different ratios of in-situ eutrophic sediment and coarse beach sand. We examined the effects of beach sand mixed with natural eutrophic sediments on seagrass using photobiology, metabolomics and isotope labelling approaches. Seagrasses grown in eutrophic sediments mixed with beach sand exhibited significantly higher photosynthetic activity, with a larger relative maximum electron transport rate and minimum saturating irradiance. Simultaneously, considerably greater belowground amino acid and flavonoid concentrations were observed to counteract anoxic stress in eutrophic sediments without mixed beach sand. This led to more positive belowground stable sulfur isotope ratios in eutrophic sediments with a lower Eh. Conclusions These results indicated that coarse beach sand indirectly enhanced photosynthesis in T. hemprichii by reducing sulfide intrusion with lower amino acid and flavonoid concentrations. This could explain why T. hemprichii often grows better on coarse sand substrates. Therefore, it is imperative to consider adding beach sand to sediments to improve the environmental conditions for seagrass and restore seagrass in eutrophic ecosystems.
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- 2021
20. Low Light Availability Reduces the Subsurface Sediment Carbon Content in Halophila beccarii From the South China Sea
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Chanaka Premarathne, Zhijian Jiang, Jialu He, Yang Fang, Qiming Chen, Lijun Cui, Yunchao Wu, Songlin Liu, Zhao Chunyu, Prabath Vijerathna, and Xiaoping Huang
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0106 biological sciences ,010504 meteorology & atmospheric sciences ,seagrass ,chemistry.chemical_element ,Plant Science ,Carbon sequestration ,01 natural sciences ,SB1-1110 ,Blue carbon ,Nutrient ,sediment carbon ,Dissolved organic carbon ,light availability ,0105 earth and related environmental sciences ,vegetative carbon ,biology ,010604 marine biology & hydrobiology ,Plant culture ,Sediment ,biology.organism_classification ,Halophila beccarii ,Seagrass ,chemistry ,Environmental chemistry ,Environmental science ,Eutrophication ,Carbon - Abstract
Eutrophication, dredging, agricultural and urban runoffs, and epiphyte overgrowth could reduce light availability for seagrass. This may affect “blue carbon” stocks in seagrass beds. However, little research is available on the effect of light intensities on carbon sequestration capacity in seagrass beds, especially small-bodied seagrasses. The dominant seagrass Halophila beccarii, a vulnerable species on the IUCN Red List, was cultured in different light intensities to examine the response of vegetation and sediment carbon in seagrass beds. The results showed that low light significantly reduced leaf length and above-ground biomass, while carbon content in both above-ground and below-ground tissues were not affected. Low light reduced both the above-ground biomass carbon and the total biomass carbon. Interestingly, while under saturating light conditions, the subsurface and surface carbon content was similar, under low light conditions, subsurface sediment carbon was significantly lower than the surface content. The reduction of subsurface sediment carbon might be caused by less release flux of dissolved organic carbon from roots in low light. Taken together, these results indicate that reduced light intensities, to which these meadows are exposed to, will reduce carbon sequestration capacity in seagrass beds. Measures should be taken to eliminate the input of nutrients on seagrass meadows and dredging activities to maintain the “blue carbon” storage service by enhancing light penetration into seagrass.
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- 2021
21. Sand Supplementation to Eutrophic Sediments Improves the Growth and Survival of Seagrass Thalassia Hemprichii: Implication for Seagrass Restoration and Management
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Zhijian Jiang, Songlin Liu, Lijun Cui, Jialu He, Yang Fang, Chanaka Premarathne, Linglan Li, Yunchao Wu, Xiaoping Huang, and Manoj Kumar
- Abstract
Aims Sediment composition is highly crucial for seagrass growth and survival. Eutrophication has been suggested a major cause of seagrass decline globally. We investigated the effects of beach sand supplementation to natural sediments under eutrophic condition on the growth and survival of tropical dominant seagrass Thalassia hemprichii. Methods We cultured seagrass T. hemprichii under the controlled laboratory conditions in three sediment types by combining different ratio of in-situ eutrophic sediment and coarse beach sand. We examined the effect of beach sand mixing to natural eutrophic sediments on the growth of seagrass using photobiology, metabolomics and isotope labeling approaches. Results Seagrass grown in eutrophic sediments mixed with sand exhibited significantly higher photosynthetic activity with high relative maximum electron transport rate and minimum saturating irradiance. Simultaneously, considerably greater belowground amino acid and flavonoid concentrations were observed to counteract anoxic stress in eutrophic sediment without mixing sand. This led to more positive belowground stable sulfur isotope in the eutrophic sediment with lower Eh. Conclusions These results indicated coarse beach sand indirectly enhanced photosynthesis and growth for T. hemprichii by reducing sulfide intrusion with lower concentrations of amino acid and flavonoid. This could possibly explain why T. hemprichii often grow better in the coarse sand substrate. Therefore, it is imperative to consider adding sand soil in the sediments to improve the growth condition for seagrass and restoring the seagrass shoots during transplantation in eutrophicated ecosystem.
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- 2021
22. The persistence and transition of multiple public goods games resolves the social dilemma
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Jialu He, Jianwei Wang, Fengyuan Yu, Wei Chen, and Wenshu Xu
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Computational Mathematics ,Applied Mathematics - Published
- 2022
23. Low Light Availability Reduces the Subsurface Sediment Carbon Content in
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Chanaka, Premarathne, Zhijian, Jiang, Jialu, He, Yang, Fang, Qiming, Chen, Lijun, Cui, Yunchao, Wu, Songlin, Liu, Zhao, Chunyu, Prabath, Vijerathna, and Xiaoping, Huang
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Halophila beccarii ,vegetative carbon ,seagrass ,sediment carbon ,Plant Science ,light availability ,Original Research - Abstract
Eutrophication, dredging, agricultural and urban runoffs, and epiphyte overgrowth could reduce light availability for seagrass. This may affect “blue carbon” stocks in seagrass beds. However, little research is available on the effect of light intensities on carbon sequestration capacity in seagrass beds, especially small-bodied seagrasses. The dominant seagrass Halophila beccarii, a vulnerable species on the IUCN Red List, was cultured in different light intensities to examine the response of vegetation and sediment carbon in seagrass beds. The results showed that low light significantly reduced leaf length and above-ground biomass, while carbon content in both above-ground and below-ground tissues were not affected. Low light reduced both the above-ground biomass carbon and the total biomass carbon. Interestingly, while under saturating light conditions, the subsurface and surface carbon content was similar, under low light conditions, subsurface sediment carbon was significantly lower than the surface content. The reduction of subsurface sediment carbon might be caused by less release flux of dissolved organic carbon from roots in low light. Taken together, these results indicate that reduced light intensities, to which these meadows are exposed to, will reduce carbon sequestration capacity in seagrass beds. Measures should be taken to eliminate the input of nutrients on seagrass meadows and dredging activities to maintain the “blue carbon” storage service by enhancing light penetration into seagrass.
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- 2021
24. Complexation-induced resolution enhancement of 3D-printed hydrogel constructs
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Pamela E. Capendale, Clément Delavaux, Valentin Huerta, Carl C. L. Schuurmans, Yu Shrike Zhang, Shikha Sebastian, Huiming Wang, Wanlu Li, Jingwei Xie, Jennifer Manríquez, Jiaxing Gong, Ruiquan Li, Tina Vermonden, Feng Cheng, Arturo López, Hongbin Li, Rosalinde Masereeuw, Mengfei Yu, Jacqueline Jialu He, Xia Cao, Anne Metje van Genderen, Afd Pharmaceutics, Afd Pharmacology, Pharmaceutics, and Pharmacology
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0301 basic medicine ,Chemistry(all) ,Polymers ,General Physics and Astronomy ,3D printing ,Biocompatible Materials ,02 engineering and technology ,Biochemistry ,Mice ,lcsh:Science ,chemistry.chemical_classification ,Multidisciplinary ,Coacervate ,Polymer network ,Tissue Scaffolds ,Soft materials ,Resolution (electron density) ,Hydrogels ,Polymer ,021001 nanoscience & nanotechnology ,Biomechanical Phenomena ,Self-healing hydrogels ,Printing, Three-Dimensional ,MCF-7 Cells ,Methacrylates ,0210 nano-technology ,3d printed ,Materials science ,Science ,Nanotechnology ,Physics and Astronomy(all) ,Methacrylate ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,Animals ,Humans ,Chitosan ,Tissue Engineering ,business.industry ,Biochemistry, Genetics and Molecular Biology(all) ,Bioprinting ,Bioinspired materials ,General Chemistry ,030104 developmental biology ,chemistry ,Gelatin ,lcsh:Q ,business ,Genetics and Molecular Biology(all) - Abstract
Three-dimensional (3D) hydrogel printing enables production of volumetric architectures containing desired structures using programmed automation processes. Our study reports a unique method of resolution enhancement purely relying on post-printing treatment of hydrogel constructs. By immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge, shrinking can rapidly occur resulting in various degrees of reduced dimensions comparing to the original pattern. This phenomenon, caused by complex coacervation and water expulsion, enables us to reduce linear dimensions of printed constructs while maintaining cytocompatible conditions in a cell type-dependent manner. We anticipate our shrinking printing technology to find widespread applications in promoting the current 3D printing capacities for generating higher-resolution hydrogel-based structures without necessarily having to involve complex hardware upgrades or other printing parameter alterations., Three-dimensional (3D) hydrogel printing enables production of volumetric architectures but achieving good resolutions for miniaturized features remains challenging. Here the authors demonstrate shrinking of a printed structure by immersing a 3D-printed patterned hydrogel consisting of a hydrophilic polyionic polymer network in a solution of polyions of the opposite net charge.
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- 2020
25. Wealth-based rule favors cooperation in costly public goods games when individual selection is inevitable
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Jialu He, Fengyuan Yu, Jianwei Wang, Wei Chen, and Wenshu Xu
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education.field_of_study ,Mechanism (biology) ,Applied Mathematics ,media_common.quotation_subject ,Polarization (politics) ,Population ,Public good ,Microeconomics ,Computational Mathematics ,Economics ,Prosperity ,education ,Selection (genetic algorithm) ,media_common - Abstract
Individual selection, as an effective mechanism, is often used in spatial evolutionary games to promote cooperation. Previous research assumes that, individual selection usually occurs with people who fail to meet a certain criterion. However, individual selection is usually inevitable, regardless of whether players in population cooperate or defect. This paper studies the effects of wealth-based rule in costly public goods games when individual selection is inevitable. Specifically, we assume that only the top V individuals with relatively high cumulative payoffs in each group can be selected for costly PGG. The results show that when V is large, the increase of participation cost has slight inhibitory effects on the evolution of cooperation, but it alleviates the polarization of individuals. However, when V is small, the increase of participation cost within a certain range promotes cooperation prosperity, but it also causes an increase in the proportion of polarized individuals and a widening of the wealth gap between rich and poor individuals.
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- 2022
26. Historical changes in seagrass beds in a rapidly urbanizing area of Guangdong Province: Implications for conservation and management
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Shuo Yu, Chunyu Zhao, Songlin Liu, Yang Fang, Jinlong Li, Chanaka Isuranga Premarathne Maha Ranvilage, Qiming Chen, Zhijian Jiang, Yunchao Wu, Lijun Cui, Jialu He, and Xiaoping Huang
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0106 biological sciences ,Oyster ,Salinity ,Halophila ovalis ,010603 evolutionary biology ,01 natural sciences ,Nutrient ,biology.animal ,lcsh:QH540-549.5 ,Sediment substrate ,Intraspecific competition ,Ecology, Evolution, Behavior and Systematics ,Nature and Landscape Conservation ,Ecology ,biology ,Nutrient optimum ,010604 marine biology & hydrobiology ,Seagrass beds ,biology.organism_classification ,Shrimp ,Seagrass ,Habitat ,Environmental science ,Historical change ,lcsh:Ecology ,Mangrove ,Eutrophication - Abstract
Rapid urbanization leads to an accelerating decline of seagrass beds. The status of seagrass beds along the entire coastline of a rapidly urbanizing area, Guangdong Province, was examined to document the change in seagrass beds and to explore the determinants of seagrasses characteristics and their plasticity. Thirteen seagrass beds were newly discovered with a total area as 679.04 ha, whereas eleven known seagrass beds have decreased from 972.55 ha to 858.67 ha with seven of them having disappeared in recent decade primarily due to exacerbated construction of artificial shorelines and beach dams, increased nutrient inputs from fish caging and shrimp pond culture, oyster culture, mangrove planting and shellfish collection. The leaf nitrogen content of Halophila ovalis, which dominated the largest beds, increased from (2.09 ± 0.24)% in 2011 to (3.39 ± 0.18)% in 2017, indicating enhanced eutrophication. The optimum seawater dissolved inorganic nitrogen and dissolved inorganic phosphorus levels for Halophila beccarii were 40 μmol/L and 2.5 μmol/L, respectively. The standing stock and plant dimensions of H. beccarii were positively correlated with sediment mud content. Longer, wider leaves, and greater aboveground and belowground biomass were observed at lower salinities, indicating that H. beccarii prefers hyposaline habitats. High shoot density could induce intraspecific competition followed by self-thinning in H. beccarii, leading to reduced leaf area, aboveground and belowground biomass, and root length. Thus, long-term monitoring of seagrass beds along the rapidly urbanizing coastline of Guangdong Province is needed to unravel the mechanisms of decline and to develop effective management strategies.
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- 2020
27. SARS-CoV-2 viral shedding characteristics and potential evidence for the priority of faecal specimen testing in diagnosis
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Chen Yuan, Hongling Wang, Kefeng Li, An Tang, Yaxin Dai, Bing Wu, Hui Zhang, Jiabei Chen, Jienan Liu, Wenjie Wu, Songye Gu, Hai Wang, Haodi Xu, Mingyu Wu, Menglu Yu, Yuchao Wang, Xinwei Yu, Jialu He, Shelan Liu, Yongli Zhang, Zhendong Tong, and Jianbo Yan
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- 2020
28. Home for Marine Species: Seagrass Leaves as Vital Spawning Grounds and Food Source
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Zhijian Jiang, Delian Huang, Yang Fang, Lijun Cui, Chunyu Zhao, Songlin Liu, Yunchao Wu, Qiming Chen, Chanaka Isuranga Premarathne Maha Ranvilage, Jialu He, and Xiaoping Huang
- Subjects
0106 biological sciences ,010504 meteorology & atmospheric sciences ,lcsh:QH1-199.5 ,seagrass ,Halophila ovalis ,Ocean Engineering ,Aquatic Science ,lcsh:General. Including nature conservation, geographical distribution ,Oceanography ,01 natural sciences ,DNA barcoding ,food source ,spawning grounds ,eggs ,lcsh:Science ,0105 earth and related environmental sciences ,Water Science and Technology ,Invertebrate ,Global and Planetary Change ,biology ,Ecology ,010604 marine biology & hydrobiology ,fungi ,biology.organism_classification ,Spawn (biology) ,Seagrass ,Monetaria annulus ,Habitat ,lcsh:Q ,Bay - Abstract
Seagrass beds provide nursery habitats for marine species. Seagrass leaves, in particular, are used as spawning grounds and as a food source for fish and invertebrates, but direct evidence of spawning in seagrass leaves is rare. It is also very challenging to identify eggs through morphological analysis, since the eggs of many marine species appear similar. To accurately identify the eggs on the leaves of the dominant seagrass species in the South China Sea, and evaluate seasonal contribution of seagrass leaves as a food source, DNA barcoding and stable isotope technique were conducted. Interestingly, Monetaria annulus was found to spawn on the leaf sheath of Thalassia hemprichii in Li’an gang, Hainan Island. This choice of oviposition site might increase embryo survival compared to the other parts of the seagrass leaves. Meanwhile, the eggs of Stethojulis trilineata were deposited on the entire leaf of Halophila ovalis in Liusha Bay, Guangdong Province. The small fingernail-shaped leaves of H. ovalis might be beneficial for S. trilineata to lay eggs as they are closer to the sediment surface than other seagrass leaves. Based on the stable carbon and nitrogen isotope analyses, the primary food source of M. annulus in summer and in winter were particulate organic matter and seagrass, respectively. The results suggest that seagrass leaves are not only important for fish and invertebrates as a spawning site, but also as a food source. The findings of the present study may support the urgent requirement of the conservation of seagrass beds for sustaining the productivity of marine fisheries.
- Published
- 2020
29. Interspecific differences in root exudation for three tropical seagrasses and sediment pore-water dissolved organic carbon beneath them
- Author
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Zhijian Jiang, Songlin Liu, Linglan Li, Yang Fang, Yunchao Wu, Jialu He, Xiaoping Huang, and Jizhen Lin
- Subjects
Carbon Sequestration ,Rhizosphere ,Alismatales ,biology ,Water ,chemistry.chemical_element ,Sediment ,Hydrocharitaceae ,Interspecific competition ,Aquatic Science ,Dissolved Organic Matter ,Oceanography ,biology.organism_classification ,Pollution ,Carbon ,Pore water pressure ,Blue carbon ,Seagrass ,chemistry ,Environmental chemistry ,Dissolved organic carbon ,Environmental science - Abstract
Seagrass beds act as blue carbon sinks globally; however, little attention has been given to carbon dynamics in the seagrass rhizosphere. Hence, in this study, the quantity and characteristics of dissolved organic carbon (DOC) from root exudation of the three dominant tropical seagrasses (Thalassia hemprichii, Enhalus acoroides, and Cymodocea rotundata) and sediment pore water beneath them were compared, to examine their interspecific differences, and to establish a connection between seagrass root exudation and sediment carbon. The rate of root-exuded DOC from T. hemprichii (2.15 ± 1.06 mg g DW root-1 h-1) was significantly higher (p
- Published
- 2021
30. Effects of emotion on the evolution of cooperation in a spatial prisoner’s dilemma game
- Author
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Fengyuan Yu, Wenshu Xu, Wei Chen, Jianwei Wang, Jialu He, and Rong Wang
- Subjects
Value (ethics) ,Computational Mathematics ,education.field_of_study ,genetic structures ,Applied Mathematics ,Self ,Population ,Prisoner's dilemma ,Social value orientations ,Psychology ,education ,Reciprocity (evolution) ,Cognitive psychology - Abstract
Emotion emerges along with individuals’ interactions, and numerous experimental studies have shown that emotion plays an important role in individual decision making. However, how emotion affects the evolution of cooperation in structured population is largely unknown. Here we introduce emotion into network reciprocity, where emotion is considered quantifiable and cumulative, and then divide individuals into two types, namely non-competitive individuals whose social value orientation is mutually beneficial and competitive individuals whose social value orientation is maximizing outcomes for the self. Here, we explore the effects of the proportion of non-competitive individuals and emotional cumulative length on the evolution of cooperation. Simulation results show that the existence of non-competitive individuals promotes cooperation in the system. Furthermore, we also find that emotional cumulative length plays a key role in promoting overall cooperation, but surprisingly, the cooperation rate of competitive individuals peaks at an intermediate value of emotional cumulative length.
- Published
- 2021
31. Inter-group selection of strategy promotes cooperation in public goods game
- Author
-
Fengyuan Yu, Wenshu Xu, Wei Chen, Jialu He, and Jianwei Wang
- Subjects
Statistics and Probability ,genetic structures ,Group (mathematics) ,media_common.quotation_subject ,Statistical and Nonlinear Physics ,Preference ,Competition (economics) ,Microeconomics ,Group selection ,Public goods game ,Business ,Imitation ,Evolutionary dynamics ,Selection (genetic algorithm) ,media_common - Abstract
Affected by geographical or social factors, human communities are organized with changeless groups for teamwork. Within groups, defection dominates because the payoffs of defectors are often higher than those of cooperators; among groups, higher cooperation level makes individuals wealthier. For the previous mechanism of evolutionary dynamics leading individuals to imitate the rich in their groups, defective strategy evolves. However, individuals who belong to different groups and have no direct interaction of interests actually could influence each other. Due to the similarity of environment, the strategies among groups have the channel and necessity of dissemination. To this end, we propose an evolutionary game model with inter-group selection of strategy. By simulations, the effects of groups’ selection preference, group size, multiplier factor, imitation intensity and competition among groups on cooperative evolution in populations are studied. We find that when the group makes selection without preference, the intensity of the choice positively affects the level of cooperation; the strategy selection with preference can effectively increase the group cooperation rate.
- Published
- 2021
32. Information sharing can suppress the spread of epidemics: Voluntary vaccination game on two-layer networks
- Author
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Fengyuan Yu, Wenshu Xu, Wei Chen, Jialu He, and Jianwei Wang
- Subjects
Statistics and Probability ,business.industry ,media_common.quotation_subject ,Information sharing ,Internet privacy ,Two layer ,Statistical and Nonlinear Physics ,Vaccination ,Turnover ,Infectious disease (medical specialty) ,Scale (social sciences) ,Social media ,Business ,Imitation ,media_common - Abstract
It is known that the vaccination is essential for suppressing the periodic prevalence of an infectious disease, while the vaccination decision is influenced by external factors. Whether or not to take vaccination depends not only on the expected benefit of individual, but also on the behavior of others. Nowadays, the speed of information transmission on the social media is fast with wide range, which extremely expands the scope of imitation, but it is unknown whether it is beneficial to vaccination. Inspired by this situation, a vaccination game model on two-layer network which increases the intensity of information sharing is proposed. The vaccination game layer and the information sharing layer are established to study the interaction between individual vaccination decisions and strategic exchanges. We find that although information sharing has inhibited individual vaccination decisions to some extent, the overall scale of disease spreading in society has decreased with increasing information sharing.
- Published
- 2021
33. Heavy metal accumulation and ecological risk on four seagrass species in South China
- Author
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Zhixin Ni, Lijun Cui, Xiaoping Huang, Zhijian Jiang, Ling Zhang, Jinlong Li, and Jialu He
- Subjects
China ,South china ,biology ,Halophila ovalis ,Bioconcentration ,Aquatic Science ,Contamination ,Oceanography ,biology.organism_classification ,Risk Assessment ,Pollution ,Metal ,Seagrass ,Bays ,Metals, Heavy ,Environmental chemistry ,visual_art ,visual_art.visual_art_medium ,Environmental science ,Ecosystem ,Bay ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Zn, Pb, Cr, Cu, Ni, Cd concentration and ecological risk were studied in three bays to evaluate the heavy metal (HM) contamination of seagrasses. Seasonal HM accumulation varied according to locations, seagrass species and tissues. Halophila beccarii had much higher HM concentrations except for Cr in Zhelin Bay, however, bioconcentration factors (BCF) of Cu, Ni, Pb, Zn were higher in Liusha than Zhelin Bay. Cr was much enriched in Thalassia hemperichii and Enhalus acoroides than Halophila beccarii and Halophila ovalis. Cr, Cu, Ni, Pb were easy to accumulate in belowground tissues in Halophila ovalis. In contrast, almost all HM were more enriched in aboveground tissues in other species. Generally, BCF exceeding 1 and high metal pollution index suggested HM had potential ecological risk on seagrasses. The results provide the reference for managing and protecting seagrass ecosystem in South China, and are significant to expand the global seagrass detection network.
- Published
- 2021
34. Heterogeneity of reputation increment driven by individual influence promotes cooperation in spatial social dilemma
- Author
-
Jialu He, Fengyuan Yu, and Jianwei Wang
- Subjects
General Mathematics ,Applied Mathematics ,media_common.quotation_subject ,Survival of the fittest ,General Physics and Astronomy ,Statistical and Nonlinear Physics ,Social dilemma ,Variation (game tree) ,Microeconomics ,Promotion (rank) ,Consistency (negotiation) ,Economics ,Selfishness ,Prosperity ,media_common ,Reputation - Abstract
Cooperation is ubiquitous, but our innate selfishness greatly challenge our motivation to cooperate since natural selection favors the fittest individuals in all the ecosystems. In addition, cooperation is costly, implementing it weighs down the individual wealth and the prosperity of human society. Therefore, how to deal with social dilemma has attracted numerous scholars’ attentions. Among previous researches, indirect reciprocity acts a crucial role in the promotion of cooperation. However, scholars focus more on the consistency and constancy of all the players’ reputation fluctuation, and ignore its potential features, the heterogeneity and dynamic of the reputation increment. In real world, such a scenario can reflect it, for example, a famous person and a notorious person have a totally distinct reputation variation even if they have coincident actions. Inspired by aforesaid particularity of reputation variation, a new mechanism, heterogeneity of reputation increment driven by individual influence is introduced, in which players who have more payoffs than the average of their neighbors’ would be more influential, and their actions would lead to a bigger scale of reputation fluctuation due to more attentions from others. Simulation results show that cooperation is facilitated effectively by our new mechanism, compared with traditional model with constant reputation variation.
- Published
- 2021
35. Development of Hydrogel‐Based Sprayable Wound Dressings for Second‐ and Third‐Degree Burns
- Author
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Gulden Camci-Unal, Jacqueline Jialu He, and Colleen McCarthy
- Subjects
wound pretreatment ,second-degree burns ,integumentary system ,Third-Degree Burn ,business.industry ,Dentistry ,third-degree burns ,Burn dressing ,sprayable hydrogels ,Medical technology ,burn dressing ,General Earth and Planetary Sciences ,Second-Degree Burn ,Medicine ,R855-855.5 ,business ,TP248.13-248.65 ,Biotechnology ,General Environmental Science - Abstract
On‐site, prehospital care is vital for minimizing the severity of injuries caused by acute burns, especially those of the second and third degrees. Burn wounds typically have irregular shapes and depths and cover a large total body area. Due to the severity and complexity of burn wounds, traditional sheet‐like wound dressings are not always suitable. Alternatively, sprayable wound dressings can be used for convenient, quick, and large‐scale dressing changes. They can also prevent infection and secondary trauma depending on their reagent content. Sprayable wound dressings function as a therapeutic barrier that provides moisturization and pain relief, absorbs extrudates, protects against bacterial infections, and acts as a delivery system for small molecules and drugs. This review discusses the recent developments in sprayable hydrogel‐based wound dressings for high‐degree burns. An introduction to burn wound classifications, the ideal burn dressing designs and characteristics, and the current availability of commercial spray‐on burn dressings are presented. To achieve the optimal healing capacities using sprayable wound dressings, researchers are currently focusing on modifying the solution viscosities, propellant systems, and pump nozzle designs for spray formulations. Finally, the use of hydrogel‐based dressings to replace skin graft surgeries for tissue regeneration is discussed.
- Published
- 2021
36. SARS-CoV-2 viral shedding characteristics and potential evidence for the priority for faecal specimen testing in diagnosis
- Author
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Hai Wang, Chen Yuan, Bing Wu, Yongli Zhang, Jiabei Chen, Songye Gu, Yaxin Dai, Shelan Liu, Kefeng Li, Wen-jie Wu, Mingyu Wu, Zhendong Tong, An Tang, Yuchao Wang, Meng-lu Yu, Jie-nan Liu, Xinwei Yu, Hui Zhang, Jialu He, Jian-Bo Yan, Hongling Wang, and Haodi Xu
- Subjects
Male ,RNA viruses ,Viral Diseases ,Coronaviruses ,Physiology ,Cross-sectional study ,Respiratory System ,Disease ,Feces ,COVID-19 Testing ,Medical Conditions ,0302 clinical medicine ,Medicine and Health Sciences ,030212 general & internal medicine ,Child ,Pathology and laboratory medicine ,Virus Testing ,Aged, 80 and over ,Multidisciplinary ,Middle Aged ,Medical microbiology ,Viral Load ,Virus Shedding ,Infectious Diseases ,medicine.anatomical_structure ,Child, Preschool ,030220 oncology & carcinogenesis ,Viruses ,Medicine ,Female ,SARS CoV 2 ,Pathogens ,Viral load ,Research Article ,Adult ,China ,Viral Release ,medicine.medical_specialty ,Adolescent ,SARS coronavirus ,Infectious Disease Control ,Science ,Research and Analysis Methods ,Microbiology ,Specimen Handling ,Young Adult ,03 medical and health sciences ,Diagnostic Medicine ,Virology ,Internal medicine ,medicine ,Humans ,Viral shedding ,Secretion ,Aged ,business.industry ,Infant, Newborn ,Organisms ,Viral pathogens ,COVID-19 ,Infant ,Biology and Life Sciences ,Covid 19 ,Microbial pathogens ,Cross-Sectional Studies ,Specimen Preparation and Treatment ,Physiological Processes ,business ,Asymptomatic carrier ,Viral Transmission and Infection ,Respiratory tract - Abstract
This study aimed to identify the specimen type that has high positivity and its proper sampling time for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing to promote diagnostic efficiency. All SARS-CoV-2-infected patients with a laboratory-confirmed diagnosis in Zhoushan City were followed up for viral shedding in respiratory tract specimens and faecal samples. Positivity was analysed both qualitatively and quantitatively by proper statistical approaches with strong testing power. Viral shedding in respiratory tract and faecal specimens was prolonged to 45 and 40 days after the last exposure, respectively. The overall positive rate in respiratory tract specimens was low and relatively unstable, being higher in the early-to-mid stage than in the mid-to-late stage of the disease course. Compared with respiratory tract specimens, faecal samples had a higher viral load, higher overall positive rate, and more stable positivity in different disease courses and varied symptomatic status. Faecal specimens have the potential ability to surpass respiratory tract specimens in virus detection. Testing of faecal specimens in diagnosis, especially for identifying asymptomatic carriers, is recommended. Simultaneously, testing respiratory tract specimens at the early-to-mid stage is better than testing at the mid-to-late stage of the disease course. A relatively small sample size was noted, and statistical approaches were used to address it. Information was missing for both specimen types at different stages of the disease course due to censored data. Our research extends the observed viral shedding in both specimen types and highlights the importance of faecal specimen testing in SARS-CoV-2 diagnosis. Healthcare workers, patients, and the general public may all benefit from our study findings. Disposal of sewage from hospitals and residential areas should be performed cautiously because the virus sheds in faeces and can last for a long time.
- Published
- 2021
37. Behavior inertia of individuals promotes cooperation in spatial prisoner's dilemma game
- Author
-
Jianwei Wang, Jialu He, and Fengyuan Yu
- Subjects
Dilemma ,Microeconomics ,Duration (philosophy) ,media_common.quotation_subject ,Economics ,General Physics and Astronomy ,Contradiction ,Prisoner's dilemma ,Inertia ,Reinforcement ,Mechanism (sociology) ,media_common - Abstract
Cooperation is ubiquitous in real world, even in a fierce competitive environment, which is in contrast with natural selection theory. To address this contradiction, many scholars pay more attention to researching the emergence and maintenance of cooperation. In recent decades, lots of mechanisms about individual behavior are put forward to promote cooperation in spatial prisoner's dilemma game. However, fewer studies focus on the effects of behavior inertia on cooperation. For example, insistence is the key to habit formation, and every extra day you insist, the more motivation you have to keep going, the bigger the inertia of the same behavior is, and the weaker the intention you have to make a change. In other words, it is easier to insist than to change. To this end, we propose a new mechanism, called inertia mechanism of individual behavior to explore the evolution of cooperation, in which each player's behavior inertia relies on the persistence of his/her current strategy: the longer the strategy duration is, the bigger his/her behavior inertia is, and, as a result, the weaker the willingness he/she has to update strategy. Moreover, a reinforcement parameter,α, which characterizes the degree of the impact of the strategy persistence on the behavior inertia, is introduced. The results of numerical simulation show that our inertia mechanism can promote cooperation effectively, compared with the traditional model, and the mechanism performs better with the decrease ofα.
- Published
- 2020
38. Reputation-based strategy persistence promotes cooperation in spatial social dilemma
- Author
-
Jianwei Wang, Lei Zheng, Fengyuan Yu, and Jialu He
- Subjects
Persistence (psychology) ,Physics ,media_common.quotation_subject ,General Physics and Astronomy ,Variation (game tree) ,Social dilemma ,Complex network ,01 natural sciences ,010305 fluids & plasmas ,Microeconomics ,Action (philosophy) ,Scale (social sciences) ,0103 physical sciences ,010306 general physics ,Mechanism (sociology) ,Reputation ,media_common - Abstract
Understanding the emergence and maintenance of cooperation in social dilemma has received a lot of attention. In previous research, many scholars found that the reputation mechanism can promote cooperation, and the variation of reputation is consistent. However, in reality, according to both one's current action and past experiences, every individual's impression from others is modified to varying extent everyday. In other words, the length of duration of the same performance influences the diverse scale of their own reputation fluctuation. Therefore, a reputation-based strategy persistence mechanism, in which the increment of current reputation is determined by the persistence of last strategy, is proposed. Moreover, we introduce a parameter α to illustrate the impact of strategy persistence on reputation variation. The results of simulation show that the new mechanism paves the way for cooperation in evolutionary game, and the smaller α is, the better the mechanism performs.
- Published
- 2020
39. Realistic decision-making process with memory and adaptability in evolutionary vaccination game
- Author
-
Meiyu Li, Wei Chen, Jianwei Wang, Fengyuan Yu, Jialu He, and Yuxin Guo
- Subjects
Process (engineering) ,Stochastic behavior ,Computer science ,General Mathematics ,Applied Mathematics ,media_common.quotation_subject ,General Physics and Astronomy ,Statistical and Nonlinear Physics ,Complex network ,01 natural sciences ,Adaptability ,010305 fluids & plasmas ,Vaccination ,Risk analysis (engineering) ,Vaccination coverage ,0103 physical sciences ,Decision-making ,010301 acoustics ,Average cost ,media_common - Abstract
Of particular importance for controlling infectious diseases by voluntary vaccination is how to understand individuals’ strategic vaccination behavior in social networks. Previous studies have always assumed an imitating and learning process by the Fermi’s rule, however, individuals’ stochastic behavior of whether to vaccinate is influenced by their intentions instead of simply imitating others. In this paper, a new strategy updating rule is proposed, demonstrating a more realistic vaccination decision-making process with memory effect and adaptability. Individuals determine whether vaccination is significant by comparing the vaccination cost and the average cost of their unvaccinated neighbors, and accordingly change their intentions to vaccinate in the next season, during which the memory effect and adaptability are taken into account. We find that the new updating rule has an extraordinary impact on the vaccination behavior of individuals, and, as a result, on the final epidemic size. It is especially noteworthy that, comparing with the traditional model, the vaccination coverage is improved and the infection size is reduced. Our results highlight that it is necessary to consider memory effect and adaptability in controlling the infectious spreading.
- Published
- 2020
40. Benefit community promotes evolution of cooperation in prisoners’ dilemma game*
- Author
-
Jialu He, Fengyuan Yu, Ke Yu, Rong Wang, Wei Chen, and Jianwei Wang
- Subjects
General Physics and Astronomy ,Prisoner's dilemma ,Business ,Criminology ,Coevolution - Abstract
Exploring the emergence and maintenance of cooperation in social dilemma is valuable and it arises considerable concerns of many researchers. In this paper, we propose a mechanism to promote cooperation, called benefit community, in which cooperators linking together form a common benefit community and all their payoffs obtained from game are divided coequally. The robustness of conclusions is tested for the PDG (prisoners’ dilemma game) on square lattice and WS small world network. We find that cooperation can be promoted by this typical mechanism, especially, it can diffuse and prevail more easily and rapidly on the WS small world network than it on the square lattice, even if a big temptation to defect b. Our research provides a feasible direction to resolve the social dilemma.
- Published
- 2019
41. Abnormal dynamics of cascading edge failures with congestion effect
- Author
-
Bo Xu, Wei Chen, Jianwei Wang, and Jialu He
- Subjects
Computer science ,General Physics and Astronomy ,Statistical and Nonlinear Physics ,Ring network ,Topology ,01 natural sciences ,Cascading failure ,010305 fluids & plasmas ,Computer Science Applications ,Computational Theory and Mathematics ,Betweenness centrality ,Robustness (computer science) ,0103 physical sciences ,Edge based ,010306 general physics ,Mathematical Physics - Abstract
Considering congestion effects in realistic network environments, we give a new method to adjust dynamically adjust the weight of the congested edge. We calculate the load on an edge based on the revised betweenness method and propose a novel model with three states of edges to investigate the dynamics of cascading failures in the ring network, the BA scale-free network, and the real traffic networks in London. By two robust metrics, we surprisingly observe the abnormal dynamics of cascading propagation, especially compared with that in the unadjustable weight, the curves of cascading dynamics in the adjustable weight are more irregular, which means that enhancing the capacity of each edge is not always better to avoid the cascading propagation. In addition, our simulation results show that the dynamical change of the edge’s weight makes the heterogeneous BA networks more vulnerable.
- Published
- 2018
42. Cetyltriethylammonium bromide stimulating transcription of Bombyx mori nucleopolyhedrovirus gp64 gene promoter mediated by viral factors
- Author
-
Yajing, Zhou, Yongzhu, Yi, Zhifang, Zhang, Jialu, He, and Yuanxing, Zhang
- Subjects
viruses ,fungi ,Article - Abstract
To characterize the effects of cetyltriethylammonium bromide (CTAB) on the transcription of gp64 promoter from Bombyx mori nucleopolyhedrovirus (BmNPV), the plasmid pBmgp64Luc used in transient expression assay system was constructed by using the luciferase gene as a reporter under the control of BmNPV gp64 promoter. When the Bombyx mori cells (Bm-N) were transfected with the pBmgp64Luc, different treatments were undertaken. We found that the transient expression activity of luciferase could not be augmented directly by CTAB treatment alone, but could be enhanced more than 2 times by BmNPV treatment alone at a multiplicity of infection (MOI) of 0.5. Through co-treatment with 0.1 microg ml(-1) of CTAB and BmNPV at a MOI of 0.5, the enzymatic activity increased 5.21 times. We presumed that the stimulation of transcription of BmNPV gp64 promoter by CTAB was mediated by viral factors from BmNPV. In addition, the time curves of luciferase activity in cells transfected with pBmgp64Luc and transactivated by virus were observed.
- Published
- 2008
43. Effects of cetyltriethylammonium bromide on the replication of Bombyx mori nucleopolyhedrovirus
- Author
-
Yajing, Zhou, Zhifang, Zhang, Jialu, He, and Yuanxing, Zhang
- Subjects
fungi ,Article - Abstract
An experimental study was undertaken to quantify the effects of cetyltriethylammonium bromide (CTAB) on the replication of Bombyx mori nucleopolyhedrovirus (BmNPV) and the transcriptionalactivity of BmNPV ie-1 promoter. The results demonstrated that the budded virus (BV) titer rose about 3.7-fold by adding CTAB to the culture media up to 0.1 mu g ml(-1) in infected Bm-N cells with a wild-type BmNPV. The transient expression level of luciferase driven by BmNPV ie-1 promoter was enhanced by more than 3-fold in the presence of 0.1 mu g ml(-1) of CTAB in uninfected insect cells via a transient expression system. Contrary to the rise in BV titer, the polyhedra inside the nucleus of infected cells dropped linearly from 4.0 x 10(6) ml(-1) down to 2.1 x 10(6) ml(-1) with in a range of CTAB concentrations from 0 to 0.25 mu g ml(-1). The same trend in expression level of beta -galactosidase or phytase was given when the Bm-N cells or fifth-instar silkworm larvae infected with a recombinant BmNPV containing the beta -galactosidase or phytase reporter gene driven by the polyhedrin promoter. We deduced that CTAB appeared to affect the virus bi-phasic life cycle stages and production pathways, resulting in an enhancement in BV production and a suppression of occluded virus (OV) production and expression of foreign genes controlled by the polyhedrin promoter.
- Published
- 2008
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