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10 results on '"Jampilek J"'

1. Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6

Author

Vanden Eynde, J.J. Mangoni, A.A. Rautio, J. Leprince, J. Azuma, Y.-T. García-Sosa, A.T. Hulme, C. Jampilek, J. Karaman, R. Li, W. Gomes, P.A.C. Hadjipavlou-Litina, D. Capasso, R. Geronikaki, A. Cerchia, L. Sabatier, J.-M. Ragno, R. Tuccinardi, T. Trabocchi, A. Winum, J.-Y. Luque, F.J. Prokai-Tatrai, K. Spetea, M. Gütschow, M. Kosalec, I. Guillou, C. Vasconcelos, M.H. Kokotos, G. Rastelli, G. De Sousa, M.E. Manera, C. Gemma, S. Mangani, S. Siciliano, C. Galdiero, S. Liu, H. Scott, P.J.H. De Los Ríos, C. Agrofoglio, L.A. Collina, S. Guedes, R.C. Muñoz-Torrero, D.

Published
2020

2. Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7

Author

Gütschow, M. Eynde, J.J.V. Jampilek, J. Kang, C. Mangoni, A.A. Fossa, P. Karaman, R. Trabocchi, A. Scott, P.J.H. Reynisson, J. Rapposelli, S. Galdier, S. Winum, J.-Y. Brullo, C. Prokai-Tatrai, K. Sharma, A.K. Schapira, M. Azuma, Y.-T. Cerchia, L. Spete, M. Torri, G. Collina, S. Geronikaki, A. García-Sosa, A.T. Helena Vasconcelos, M. Sousa, M.E. Kosalec, I. Tuccinardi, T. Duarte, I.F. Salvador, J.A.R. Bertinaria, M. Pellecchia, M. Amato, J. Rastelli, G. Gomes, P.A.C. Guedes, R.C. Sabatier, J.-M. Estévez-Braun, A. Pagano, B. Mangani, S. Ragno, R. Kokotos, G. Brindisi, M. González, F.V. Borges, F. Miloso, M. Rautio, J. Muñoz-Torrero, D.

Published
2020

3. Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity

Author

Vettorazzi M, Vila L, Lima S, Acosta L, Yepes F, Palma A, Cobo J, Tengler J, Malik I, Alvarez S, Marques P, Cabedo N, Sanz M, Jampilek J, Spiegel S, and Enriz R

Abstract

The synthesis of inhibitors of SphK2 with novel structural scaffolds is reported. These compounds were designed from a molecular modeling study, in which the molecular interactions stabilizing the different complexes were taken into account. Particularly interesting is that 7-bromo-2-(2-phenylethyl)-2,3,4,5-tetrahydro-1,4-epoxynaphtho[1,2-b]azep ine, which is a selective inhibitor of SphK2, does not exert any cytotoxic effects and has a potent anti-inflammatory effect. It was found to inhibit mononuclear cell adhesion to the dysfunctional endothelium with minimal impact on neutrophil-endothelial cell interactions. The information obtained from our theoretical and experimental study can be useful in the search for inhibitors of SphK2 that play a prominent role in different diseases, especially in inflammatory and cardiovascular disorders.

Published
2019

4. Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5

Author

Mangoni, A.A. Eynde, J.J.V. Jampilek, J. Hadjipavlou-Litina, D. Liu, H. Reynisson, J. Sousa, M.E. Gomes, P.A.C. Prokai-Tatrai, K. Tuccinardi, T. Sabatier, J.-M. Luque, F.J. Rautio, J. Karaman, R. Vasconcelos, M.H. Gemma, S. Galdiero, S. Hulme, C. Collina, S. Gütschow, M. Kokotos, G. Siciliano, C. Capasso, R. Agrofoglio, L.A. Ragno, R. Muñoz-Torrero, D.

Published
2019

5. Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4

Author

Mangoni, A.A. Guillou, C. Eynde, J.J.V. Hulme, C. Jampilek, J. Li, W. Prokai-Tatrai, K. Rautio, J. Collina, S. Tuccinardi, T. Sousa, M.E. Sabatier, J.-M. Galdiero, S. Karaman, R. Kokotos, G. Torri, G. Javier Luque, F. Helena Vasconcelos, M. Hadjipavlou-Litina, D. Siciliano, C. Gütschow, M. Ragno, R. Gomes, P.A.C. Agrofoglio, L.A. Muñoz-Torrero, D.

Published
2019

6. The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †

Author

Mucaji, P. Atanasov, A.G. Bak, A. Kozik, V. Sieron, K. Olsen, M. Pan, W. Liu, Y. Hu, S. Lan, J. Haider, N. Musiol, R. Vanco, J. Diederich, M. Ji, S. Zitko, J. Wang, D. Agbaba, D. Nikolic, K. Oljacic, S. Vucicevic, J. Jezova, D. Tsantili-Kakoulidou, A. Tsopelas, F. Giaginis, C. Kowalska, T. Sajewicz, M. Silberring, J. Mielczarek, P. Smoluch, M. Jendrzejewska, I. Polanski, J. Jampilek, J.

Abstract

The 46th EuroCongress on Drug Synthesis and Analysis (ECDSA-2017) was arranged within the celebration of the 65th Anniversary of the Faculty of Pharmacy at Comenius University in Bratislava, Slovakia from 5–8 September 2017 to get together specialists in medicinal chemistry, organic synthesis, pharmaceutical analysis, screening of bioactive compounds, pharmacology and drug formulations; promote the exchange of scientific results, methods and ideas; and encourage cooperation between researchers from all over the world. The topic of the conference, “Drug Synthesis and Analysis,” meant that the symposium welcomed all pharmacists and/or researchers (chemists, analysts, biologists) and students interested in scientific work dealing with investigations of biologically active compounds as potential drugs. The authors of this manuscript were plenary speakers and other participants of the symposium and members of their research teams. The following summary highlights the major points/topics of the meeting.

Published
2017

9. Breakthroughs in medicinal chemistry: new targets and mechanisms, new drugs, new hopes-7

Author

Gütschow, Michael, Eynde, Jean Jacques Vanden, Jampilek, Josef, Kang, CongBao, Mangoni, Arduino, Fossa, Paola, Karaman, Rafik, Trabocchi, Andrea, Scott, Peter, Reynisson, Jóhannes, Rapposelli, Simona, Galdiero, Stefania, Winum, Jean-Yves, Brullo, Chiara, Prokai-Tatrai, Katalin, Sharma, Arun, Schapira, Matthieu, Azuma, Yasu-Taka, Cerchia, Laura, Spetea, Mariana, Torri, Giangiacomo, Collina, Simona, Geronikaki, Athina, García-Sosa, Alfonso, Vasconcelos, M Helena, Sousa, Maria Emília, Kosalec, Ivan, Tuccinardi, Tiziano, Duarte, Iola, Salvador, Jorge, Bertinaria, Massimo, Pellecchia, Maurizio, Amato, Jussara, Rastelli, Giulio, Gomes, Paula, Guedes, Rita, Sabatier, Jean-Marc, Estévez-Braun, Ana, Pagano, Bruno, Mangani, Stefano, Ragno, Rino, Kokotos, George, Brindisi, Margherita, González, Florenci, Borges, Fernanda, Miloso, Mariarosaria, Rautio, Jarkko, Muñoz-Torrero, Diego, Vanden Eynde, Jean Jacques, Vasconcelos, M. Helena, Gutschow, M., Eynde, J. J. V., Jampilek, J., Kang, C., Mangoni, A. A., Fossa, P., Karaman, R., Trabocchi, A., Scott, P. J. H., Reynisson, J., Rapposelli, S., Galdiero, S., Winum, J. -Y., Brullo, C., Prokai-Tatrai, K., Sharma, A. K., Schapira, M., Azuma, Y. -T., Cerchia, L., Spete, M., Torri, G., Collina, S., Geronikaki, A., Garcia-Sosa, A. T., Helena Vasconcelos, M., Sousa, M. E., Kosalec, I., Tuccinardi, T., Duarte, I. F., Salvador, J. A. R., Bertinaria, M., Pellecchia, M., Amato, J., Rastelli, G., Gomes, P. A. C., Guedes, R. C., Sabatier, J. -M., Estevez-Braun, A., Pagano, B., Mangani, S., Ragno, R., Kokotos, G., Brindisi, M., Gonzalez, F. V., Borges, F., Miloso, M., Rautio, J., Munoz-Torrero, D., Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Gutschow, M, Eynde, J, Jampilek, J, Kang, C, Mangoni, A, Fossa, P, Karaman, R, Trabocchi, A, Scott, P, Reynisson, J, Rapposelli, S, Galdier, S, Winum, J, Brullo, C, Prokai-Tatrai, K, Sharma, A, Schapira, M, Azuma, Y, Cerchia, L, Spete, M, Torri, G, Collina, S, Geronikaki, A, Garcia-Sosa, A, Helena Vasconcelos, M, Sousa, M, Kosalec, I, Tuccinardi, T, Duarte, I, Salvador, J, Bertinaria, M, Pellecchia, M, Amato, J, Rastelli, G, Gomes, P, Guedes, R, Sabatier, J, Estevez-Braun, A, Pagano, B, Mangani, S, Ragno, R, Kokotos, G, Brindisi, M, Gonzalez, F, Borges, F, Miloso, M, Rautio, J, and Munoz-Torrero, D

Subjects
RM, Pharmaceutical research, molecular targeted therapy, Chemistry, Pharmaceutical, MESH: Pharmaceutical Preparations, [SDV]Life Sciences [q-bio], Pharmaceutical Science, animals, chemistry, pharmaceutical, drug discovery, humans, pharmaceutical preparations, structure-activity relationship, Q1, chemistry, 01 natural sciences, Clinical chemistry, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, MESH: Chemistry, Pharmaceutical, Química clínica, MESH: Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Drug Discovery, CHIM/06 - CHIMICA ORGANICA, MESH: Molecular Targeted Therapy, pharmaceutical, MESH: Animals, RM695, Investigació farmacèutica, Physical and Theoretical Chemistry, 030304 developmental biology, 0303 health sciences, MESH: Humans, 010405 organic chemistry, Medicinal Chemistry, New Targets, New Mechanisms, New Drugs, Organic Chemistry, R735, R1, 3. Good health, 0104 chemical sciences, Editorial, n/a, Chemistry (miscellaneous), Molecular Medicine, Breakthroughs, Medicinal Chemistry, medicinal chemistry, targets, drugs, molecules, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addressing prime unmet medical needs.

Published
2020

10. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

Author

Arduino Mangoni, Jean Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Sousa, Paula Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean-Marc Sabatier, F. Luque, Jarkko Rautio, Rafik Karaman, M. Vasconcelos, Sandra Gemma, Stefania Galdiero, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi Agrofoglio, Rino Ragno, Diego Muñoz-Torrero, Flinders University [Adelaide, Australia], University of Mons [Belgium] (UMONS), Comenius University in Bratislava, Aristotle University of Thessaloniki, Chinese Academy of Sciences [Beijing] (CAS), Keele University [Keele], Universidade do Porto, University of North Texas Health Science Center [Fort Worth], University of Pisa - Università di Pisa, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Barcelona, University of Eastern Finland, Al-Quds University, University of Siena (University of Siena), University of Naples Federico II, University of Arizona, University of Pavia, University of Bonn, National and Kapodistrian University of Athens (NKUA), University of Calabria, Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Universitat de Barcelona, Universidade do Porto = University of Porto, Università degli Studi di Siena = University of Siena (UNISI), University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli Studi di Pavia = University of Pavia (UNIPV), Universität Bonn = University of Bonn, Università della Calabria [Arcavacata di Rende] (Unical), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Instituto de Investigação e Inovação em Saúde, Leloup, Ludovic, Mangoni, A. A., Eynde, J. J. V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M. E., Gomes, P. A. C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J. -M., Luque, F. J., Rautio, J., Karaman, R., Vasconcelos, M. H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gutschow, M., Kokotos, G., Siciliano, C., Capasso, Raffaele, Agrofoglio, L. A., Ragno, R., and Munoz-Torrero, D.

Subjects
Chemistry, Pharmaceutical, [SDV]Life Sciences [q-bio], Pharmaceutical Science, Drug Discovery / trends, Química farmacèutica, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, RS, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Drug Discovery, [CHIM] Chemical Sciences, Humans, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, breakthroughs in medicinal chemistry, new targets, new mechanisms, new drugs, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Organic Chemistry, 3. Good health, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Chemistry, Editorial, Chemistry, Pharmaceutical / trends, n/a, Chemistry (miscellaneous), Pharmaceutical, Molecular Medicine, Pharmaceutical chemistry, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these Editorials, we highlight in brief reports (of about one hundred words) a number of recently published articles that describe crucial findings, such as the discovery of novel drug targets and mechanisms of action or novel classes of drugs, which may inspire future medicinal chemistry endeavors devoted to addressing prime unmet medical needs.

Published
2019

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