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Additional file 1: Supplementary Table 1. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) Checklist for Prediction model development. Supplementary Table 2. Algorithms of ICD-9 and 10 codes used to define components of our composite outcome. Supplementary Table 3. Candidate Predictor definition along with source of data and ICD-9/10 algorithms if applicable. Supplementary Table 4. Surgical Categories by Canadian Classification of Health Intervention (CCI) codes. Supplementary Table 5. Estimated Sample Size Calculations using ‘pmsampsize’ in Stata software v17.0 and as suggested by Riley et al (2020). Supplementary Table 6. Top causes of death for those that died within 30 days of surgery, with associated ICD-10 codes. Supplementary Table 7. Performance of models evaluated in cohort with only first surgery per participant. Supplementary Table 8. Event and non-eventReclassification Tables between models, stratified by clinically important probability categories. Supplementary Figure 1. Decision Curve Analysis to estimate the net benefit of use of perioperative risk prediction models in ambulatory or inpatient elective surgery (sensitivity analysis).

Supplemental Material, sj-docx-1-ptd-10.1177_08968608221086752 for The availability of support and peritoneal dialysis survival: A cohort study by Danielle E Fox, Kathryn M King-Shier, Matthew T James, Lorraine Venturato, Alix Clarke, Pietro Ravani, Matthew J Oliver and Robert R Quinn in Peritoneal Dialysis International

Additional file 1:.

Supplemental material, CJKHD_Supplemental_Material_-_Appendix_1-3_Revised_Clean_Copy_-_June_29_2020_1 for Derivation and Internal Validation of a Clinical Risk Prediction Tool for Hyperkalemia-Related Emergency Department Encounters Among Hemodialysis Patients by Paul E. Ronksley, James P. Wick, Meghan J. Elliott, Robert G. Weaver, Brenda R. Hemmelgarn, Andrew McRae, Matthew T. James, Tyrone G. Harrison and Jennifer M. MacRae in Canadian Journal of Kidney Health and Disease

Supplemental_Tables_JICM for Comparative Prognostic Accuracy of Risk Prediction Models for Cardiogenic Shock by Robert J. H. Miller, Danielle Southern, Stephen B. Wilton, Matthew T. James, Bryan Har, Greg Schnell, Sean van Diepen and Andrew D. M. Grant in Journal of Intensive Care Medicine

Supplemental material, Supplementary_Figure_1,2_and_3_(1) for Kidney Function, ACE-Inhibitor/Angiotensin Receptor Blocker Use, and Survival Following Hospitalization for Heart Failure: A Cohort Study by Michael H. Chiu, Robert J. H. Miller, Rebecca Barry, Bing Li, Bryan J. Har, Stephen B. Wilton, Merril Knudtson, Jonathan G. Howlett and Matthew T. James in Canadian Journal of Kidney Health and Disease

Patients with end-stage renal disease (ESRD) are at a high risk of bacterial infection. We reviewed publications on risk factors, prevention, and treatment paradigms, as well as outcomes associated with bacterial infection in end-stage kidney disease. We focused in particular on studies conducted in Canada where rates of haemodialysis catheter use are high.We included original research articles in English text identified from MEDLINE using search terms 'chronic kidney failure', 'renal dialysis', or 'chronic renal insufficiency', and 'bacterial infection'. We focused on articles with Canadian study populations and included comparisons to international standards and outcomes where possible.Bacterial infections in this setting are most commonly due to Gram-positive skin flora, particularly Staphylococcus, with methicillin-resistant Staphylococcus aureus (MRSA) carrying a poorer prognosis. Interventions that may decrease mortality from sepsis include a collaborative care model that includes a nephrology team, an infectious disease specialist, and use of standardized care bundles that adhere to proven quality-of-care indicators. Decreased infectious mortality may be achieved by ensuring appropriate antibiotic selection and dosing as well as avoiding catheter salvage attempts. Reduction in bloodstream infection (BSI) incidence has been observed with the use of tPA catheter-locking solutions and the use of mupirocin or polysporin as a topical agent at the catheter exit site, as well as implementing standarized hygiene protocols during catheter use.There has been a paucity of randomized controlled trials of prevention and treatment strategies for catheter-related BSIs in haemodialysis. Some past trials have been limited by lack of blinding and short duration of follow-up. Microbiological epidemiology, although well characterized, may vary by region and treatment centre.With the high prevalence of catheter use in Canadian haemodialysis units, further studies on long-term treatment and preventative strategies for BSI are warranted.Les patients souffrant d’insuffisance rénale terminale (IRT) sont à risque élevé de contracter une infection bactérienne. Nous avons effectué une revue des publications faisant état des facteurs de risque, des paradigmes de prévention et de traitement, ainsi que des pronostics associés à la contraction d’une septicémie en situation d’IRT. On a porté une attention particulière aux études conduites au Canada, où le taux d’hémodialyse par accès vasculaire est élevé.Nous avons inclus tous les articles rédigés en anglais répertoriés sur MEDLINE qui répondaient aux critères de recherche suivants : « hémodialyse », « insuffisance rénale chronique » et « infection bactérienne ». L’accent a été mis sur les articles portant sur des études s’étant tenues au Canada, en incluant des comparaisons aux pronostics et aux standards internationaux lorsque possible.La plupart des infections bactériennes dans ce contexte particulier sont attribuables à des bactéries Gram positif, plus spécifiquement àIl existe très peu d’essais cliniques randomisés rapportant des stratégies de prévention ou de traitement des bactériémies liées à l’utilisation de cathéters pour l’hémodialyse.Étant donné la prévalence élevée d’utilisation de cathéters dans les unités de dialyse au Canada, il est suggéré d’effectuer des études supplémentaires afin d’élaborer des stratégies à long terme pour la prévention et le traitement des infections du sang.

Human negligence and ignorance concerning LPG handling can cause serious risks which may lead to fire and explosion. This study aims to create an automated system that intervenes human processes and implements necessary precautions based on the current state of the concerned area. The fulfillment of this study has produced a small scale system capable of detecting LPG concentration within the accuracy range of 85% to 100%. Results of this study shows that after detecting LPG in the environment, the system then implements specified action and notification procedures with 100% accuracy, thus preventing LPG leakage hazards to aggravate.

Article deposited according to agreement with BMC, December 6, 2010.

Background Administrative health care databases offer an efficient and accessible, though as-yet unvalidated, approach to studying outcomes of patients with chronic kidney disease and end-stage renal disease (ESRD). The objective of this study is to determine the validity of outpatient physician billing derived algorithms for defining chronic dialysis compared to a reference standard ESRD registry. Methods A cohort of incident dialysis patients (Jan. 1 - Dec. 31, 2008) and prevalent chronic dialysis patients (Jan 1, 2008) was selected from a geographically inclusive ESRD registry and administrative database. Four administrative data definitions were considered: at least 1 outpatient claim, at least 2 outpatient claims, at least 2 outpatient claims at least 90 days apart, and continuous outpatient claims at least 90 days apart with no gap in claims greater than 21 days. Measures of agreement of the four administrative data definitions were compared to a reference standard (ESRD registry). Basic patient characteristics are compared between all 5 patient groups. Results 1,118,097 individuals formed the overall population and 2,227 chronic dialysis patients were included in the ESRD registry. The three definitions requiring at least 2 outpatient claims resulted in kappa statistics between 0.60-0.80 indicating "substantial" agreement. "At least 1 outpatient claim" resulted in "excellent" agreement with a kappa statistic of 0.81. Conclusions Of the four definitions, the simplest (at least 1 outpatient claim) performed comparatively to other definitions. The limitations of this work are the billing codes used are developed in Canada, however, other countries use similar billing practices and thus the codes could easily be mapped to other systems. Our reference standard ESRD registry may not capture all dialysis patients resulting in some misclassification. The registry is linked to on-going care so this is likely to be minimal. The definition utilized will vary with the research objective.

Background Previously published equations to adjust calcium for albumin concentration may vary depending on factors such as the type of reagents used. Albumin-adjusted calcium equations derived from laboratories using the bromocresol purple (BCP) albumin binding reagent have not been described. Methods The linear regression equation for the binding of calcium and BCP-albumin was derived in a cohort of 4613 outpatients, and the albumin-adjusted calcium equation was internally validated in a separate cohort of 1538 subjects. The performance of this equation was compared with a previously published equation (adjusted [Ca](mmol/L) = total [Ca](mmol/L) + 0.02 (40 - [albumin] (g/L)) in 343 subjects with albumin < 33 g/L (below reference range). Results The local adjustment equation was expressed by the relationship; adjusted [Ca](mmol/L) = total [Ca](mmol/L) + 0.012 (39.9 - [albumin](g/L)). The equation showed evidence of good internal validity (shrinkage value of adjusted r2 = -0.0059). Classification of calcium status differed between the two equations in 47 of 343 subjects with low serum albumin (weighted κ = 0.46; moderate agreement). Conclusion A locally derived and internally validated albumin-adjusted calcium equation differed from previously published equations and resulted in important differences in classification of calcium status in hypoalbuminemia patients. Individual laboratories should determine their own linear regression equation for calcium on albumin rather than relying on published formulas.

Background Multimorbidity is common and associated with poor clinical outcomes and high health care costs. Administrative data are a promising tool for studying the epidemiology of multimorbidity. Our goal was to derive and apply a new scheme for using administrative data to identify the presence of chronic conditions and multimorbidity. Methods We identified validated algorithms that use ICD-9 CM/ICD-10 data to ascertain the presence or absence of 40 morbidities. Algorithms with both positive predictive value and sensitivity ≥70% were graded as “high validity”; those with positive predictive value ≥70% and sensitivity

Additional file 1. Supplementary material.

Additional file 1. Supplementary material.