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Market prediction plays a major role in supporting financial decisions. An emerging approach in this domain is to use graphical modeling and analysis to for prediction of next market index fluctuations. One important question in this domain is how to construct an appropriate graphical model of the data that can be effectively used by a semi-supervised GNN to predict index fluctuations. In this paper, we introduce a framework called NETpred that generates a novel heterogeneous graph representing multiple related indices and their stocks by using several stock-stock and stock-index relation measures. It then thoroughly selects a diverse set of representative nodes that cover different parts of the state space and whose price movements are accurately predictable. By assigning initial predicted labels to such a set of nodes, NETpred makes sure that the subsequent GCN model can be successfully trained using a semi-supervised learning process. The resulting model is then used to predict the stock labels which are finally aggregated to infer the labels for all the index nodes in the graph. Our comprehensive set of experiments shows that NETpred improves the performance of the state-of-the-art baselines by 3%-5% in terms of F-score measure on different well-known data sets.

OBJECTIVE (S): Diabetes is the most common metabolic disease with an increasing prevalence throughout the world due to the changes in lifestyle. Appropriate self-care promotes the life condition of people with chronic illnesses and reduces the side effects of such diseases, so this study was designed to develop a scale for evaluating self-care in middle-aged patients diabetes. METHODS: In this methodological study, the following 4 steps were conducted for design and psychometric measurement of the questionnaire: 1) Data collection was carried out during a supplementary cross-sectional survey of the qualitative study; 2) determining the face validity (the assessment of facility, difficulty, and ambiguity of the items and their importance for patients) and content validity of the questionnaire (the assessment of appropriateness and necessity of items by experts opinions and measuring CVR and CVI; 3) the internal consistency of the questionnaire was evaluated by determining the Cranach’s alpha coefficient (α = 0.85), and 4) test-retest of the scale with a 2-weeks interval confirmed appropriate stability for the scale (ICC = 0.81). The normality of data was also evaluated using skewness and kurtosis. CFA was performed using AMOS version 24 software. RESULTS: The first version of this questionnaire was produced with 71 items, of which 27 items were deleted during the process of validity and reliability confirmation. The final version of the questionnaire was provided with 44 items. For this study, 460 samples were used to examine the psychometric properties of the self-care scale.The confirmatory factor analysis showed a good fit to the data. Before the performing CFA, KMO and Bartlett’s test of sphericity were evaluated and the results indicated an adequate sample (KMO = 0.956 and Bartlett’s test: χ2 = 14,288.048, df = 946, P

Additional file 1. Persian version of Depression Literacy (D-Lit) questionnaire (21 Items)

Additional file 3: Table S2. Qualities of studies included in the systematic review and meta-analysis.

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Additional file 2: Table S1. Population characteristics of the studies reported the lifetime and current prevalence of electronic cigarette (e-cigarettes) vaping among women and men.

Additional file 1. Search Strategy.

Additional file 2: Table S1. Population characteristics of the studies reported the lifetime and current prevalence of electronic cigarette (e-cigarettes) vaping among women and men.

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Additional file 3: Table S2. Qualities of studies included in the systematic review and meta-analysis.

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Additional file 3. Questionnaire of Knowledge towards CAM modalities.

Additional file 1. Demographic Characteristics Questionnaire.

Additional file 1. Questionnaire of CAM practice and reason for using of CAM modalities.

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Additional file 4. Questionnaire of using of CAM modalities.

Additional file 2. Questionnaire of Attitude towards CAM modalities.

Thorough knowledge from anatomical characteristics of different teeth is a must, to achieve successful root canal, Orthodontic, surgical and other dental treatments on them. This cross- sectional study aimed to study the anatomy and morphology of permanent maxillary canine teeth in Kerman, a province in the southeast Islamic Republic of Iran. One hundred extracted permanent maxillary canines with intact apices were collected from five different dental centers within five different city districts in Kerman. The number of roots, the root curve direction and the length of each tooth was assigned by macroscopic observation and length measurement of each sample. Also, after staining, decalcification and clearing of each selected tooth the existence of lateral canals and their location was carefully evaluated under magnification. The results showed that all maxillary canine teeth had 1 root and one root canal in this study. The average length for this tooth was 27.31mms. The curve direction of the roots, in 32% of the cases was; distally, in 8%; buccally, in 4%; mesially and in 3%; palatally. 53% of the teeth had straight roots and root canals and, 25%, had lateral canals that in all of the cases were located in the apical third of the roots and were never observed in the middle and coronal thirds. As a conclusion, in this population, roots of maxillary canine teeth have straight roots in 53% of the cases, and in 25%, they have lateral canals that are usually located in the apical thirds., Italian Journal of Anatomy and Embryology, Vol. 124 No. 3 (2019)

This systematic review and meta-analysis aimed to investigate the effect of zinc supplementation on immune factors in randomized controlled trials. A comprehensive search was done in PubMed, Scopus, Web of Science, Embase, and Cochrane databases up to December 2020. We used standard and weighted mean differences and 95% confidence intervals for net changes in selected parameters of immune responses. Subgroup analysis was used to find heterogeneity. Overall, 35 RCTs comprising 1995 participants were eligible for this meta-analysis. There was a significant reduction of circulating CRP (WMD: −32.4; 95% CI: −44.45 to −19.62, p < 0.001), hs-CRP (WMD: −0.95; 95% CI: −1.01 to −0.89, p < 0.001), Neutrophil levels (SMD: −0.46; 95% CI: −0.90 to −0.01, p = 0.043), following zinc supplementation. CD4 level also increased significantly, (WMD: 1.79; 95% CI: 0.57 to 3, p = 0.004). Zinc supplementation had no significant effect on WBC (SMD: −0.66; 95% CI: −1.67 to 0.36, p = 0.204), lymphocyte (WMD: 1.86; 95% CI: −0.86 to 4.58, p = 0.181), monocyte levels (SMD: −0.16; 95% CI: −0.07 to 0.39, p = 0.167), CD3 (SMD: 0.37; 95% CI: −0.49 to 1.22, p = 0.399). Zinc supplementation decreased the CRP, hs-CRP and TNF-α, IL-6, neutrophil and increased CD3 and CD4 level significantly.

Mohsen Heidary,1,2 Saeed Zaker Bostanabad,3,4 Seyed Mohammad Amini,5 Alireza Jafari,6 Mostafa Ghalami Nobar,4,7 Arash Ghodousi,8 Morteza Kamalzadeh,9 Davood Darban-Sarokhalil1 1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; 2Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; 3Microbiology Department, Islamic Azad University-Parand Branch, Tehran, Iran; 4Mycobacteriology Department, Massoud Laboratory, Tehran, Iran; 5Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; 6Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; 7Reference Health Laboratory of Iran (RHL), Ministry of Health and Medical Education, Tehran, Iran; 8Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy; 9Quality Control, Department, Razi Vaccine and Research Institute, Agricultural Research Education and Extension Organization, Karaj, IranCorrespondence: Davood Darban-SarokhalilDepartment of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, IranEmail davood_darban@yahoo.comBackground: Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) – and extensively drug-resistant (XDR) – Mycobacterium tuberculosis (M. tuberculosis) is identified as one of the most challenging threats to TB control. Thus, new and safe nano-drugs are urgently required for the elimination of TB. The aim of this study was to investigate the anti-bacterial effects of Ag, ZnO, and Ag-ZnO nanoparticles (NPs) on MDR- and XDR-M. tuberculosis.Materials and methods: In this study, Ag, ZnO, and Ag-ZnO NPs were synthesized by the chemical reduction and chemical deposition methods. NPs were characterized using ultraviolet–visible spectroscopy, dynamic light scattering, and transmission electron microscopy. Then, various dilutions of NPs were prepared and their minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined against M. tuberculosis strains using the broth microdilution and agar microdilution methods. Finally, MTT test and cell culture assay were performed.Results: The effects of concentrations of 1–128 μg/mL Ag NPs, ZnO NPs, 2Ag: 8ZnO, 8Ag:2ZnO, 3Ag: 7ZnO, 7Ag:3ZnO, and 5Ag:5ZnO on M. tuberculosis strains were investigated. MIC results showed the inhibitory effect of 1 μg/mL of all NPs against XDR-M. tuberculosis. In addition, the concentrations of 4 μg/mL Ag, 8 μg/mL 5Ag:5ZnO, 8 μg/mL 7Ag:3ZnO, 32 μg/mL 3Ag:7ZnO, 16 μg/mL 8Ag:2ZnO, and 64 μg/mL 2Ag:8ZnO inhibited MDR-M. tuberculosis growth. However, MBC results indicated the inability of Ag, ZnO and Ag-ZnO NPs, either in combination or alone, to kill MDR- or XDR-M. tuberculosis.Conclusion: To the best of our knowledge, this is the first study to evaluate the effects of Ag and ZnO NPs against MDR and XDR strains of M. tuberculosis. According to the results, Ag and ZnO NPs showed bacteriostatic effects against drug-resistant strains of M. tuberculosis. Therefore, these NPs may be considered as promising anti-mycobacterial nano-drugs. However, further studies are required to affirm the bactericidal effects of these NPs against TB.Keywords: Mycobacterium tuberculosis, silver, zinc oxide, nanoparticle, MDR-TB, XDR-TB

Surfzone wave transformation under storm conditions is investigated through field and laboratory measurements in this study. The observations have been used to examine currently available models of wave energy dissipation. Detailed field data has been collected by means of a novel method which was first introduced by Nielsen (1988). This method has been utilised through a common program between Griffith University and The University of Queensland at The Spit on the Gold Coast in Southeast Queensland. The facility primarily consists of a manometer tube array with 12 different manometer tube lengths varying from 60 m to 500 m offshore and a concrete manhole excavated into the dune system to house the monitoring station. Accordingly, this system has enabled the monitoring of a detailed wave height profile across the surfzone under any conditions from the safety of the “bunker” on land. The findings of new laboratory experiments on the frequency response of the semi-rigid manometer tubes are also presented which extend and improve upon the previous work of Nielsen et al. (1993). Testing was conducted over a range of frequencies (0.0067 Hz< f

The development of underground infrastructure, environmental concerns, and economic trend is influencing society. Due to the increasingly critical nature of installations of utility systems especially in congested areas, the need for monitoring and control system has increased. The microtunneling system will therefore have to provide for possibility of minimized surface disruption. Suitable selection of Microtunneling Boring Machine (MTBM) is the most curial decision that manager must be done. Because once the trenchless excavation has started, it might be too late to make any changes in equipment without extra costs and delays. Therefore, the various factors and parameters are affecting the choice of machine. In this paper discusses a developed methodology based on Fuzzy Analytic Hierarchy Process (FAHP) in order to determine weights of the criteria and sub criteria and then ranking them. Within the proposed model, four criteria site, machinery, structural, labor force impact and 18 sub-criteria are specified. The linguistic level of comparisons produced by experts are tapped and constructed in a form of triangular fuzzy numbers in order to construct fuzzy pair wise comparison matrices. Therefore, FAHP uses the pair wise comparison matrices for determining the weights of the criteria and sub-criteria. El desarrollo de infraestructura subterránea, con preocupaciones ambientales y tendencias económicas, está influyendo a la sociedad. Debido a la naturaleza crecientemente crítica de las instalaciones de sistemas utilitarios, especialmente en áreas congestionadas, ha aumentado la necesidad de sistemas de monitoreo y control. Por lo tanto el sistema de microtunelación ayudará a minimizar la superficie perturbada. La selección adecuada de Máquinas Taladradoras de Microtúnel (MTBM, por sus siglas en inglés) es la decisión más juiciosa que puede hacerse, puesto que una vez que la excavación sin zanjas ha iniciado, podría ser muy tarde para hacer cambios en el equipo sin un costo ni atrasos adicionales. Luego, los diversos factores y parámetros afectan la escogencia de la máquina. En este artículo se discute una metodología desarrollada, que se basa en el Proceso Jerárquico Analítico Difuso (FACH) para determinar pesos de los criterios y subcriterios, y luego ordenarlos. En el modelo propuesto se especifican cuatro criterios de sitio, maquinaria, estructura, impacto de la fuerza laboral y 18 subcriterios. Los niveles lingüísticos de comparaciones producidos por expertos se construyen en forma de números difusos triangulares para construir matrices de comparación difusa por parejas. Por lo tanto el FAHP usa las matrices de comparación por parejas para determinar los pesos de los criterios y subcriterios

To study the frequency of amblyogenic factors in patients with congenital ptosis.In this cross-sectional study, 114 eyes of 100 patients with congenital ptosis more than 1 year old were included. Amblyopia was defined as best-corrected visual acuity (BCVA) less than 10/10 or a difference between the two eyes of at least 2/10. In patients too young to be measured by the linear Snellen E test, fixation behavior was observed. Different types of amblyopia were assessed for each patient as: 1) anisometropic amblyopia: astigmatic anisometropia ≥1 dpt, hyperopic spherical anisometropia ≥1 dpt, myopic spherical anisometropia ≥-3 dpt (with cycloplegia); 2) strabismic amblyopia, and 3) stimulus deprivation amblyopia (SDA). Then the total incidence of amblyopia and each type of it were obtained. Patients with uni- and bi-lateral ptosis were also compared.The incidence of amblyopia in ptotic eyes was 39/114 (34.2 %), and for each specific cause was: refractive amblyopia in 29.8%, SDA in 10.5%, strabismic amblyopia in 4.3%. Amblyopia was more frequent in severe ptosis, 76% in patients with covered optical axes (OA), compared to non-covered OA (22.5%). In unilateral ptosis with covered OA, astigmatic anisometropic amblyopia was more frequent, and in bilateral ptosis with at least one eye covered OA, spherical anisometropic amblyopia was more frequent. In both unilateral and bilateral ptosis, SDA was more common if the OA was covered.As refractive anisometropic amblyopia is more prevalent than SDA, paying attention to all causes of amblyopia may be important in preventing amblyopia in a child with a ptotic eye.