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Here we describe a case of a composite mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small cell lymphocytic lymphoma (CLL/SLL) with 17p deletion in the MCL. The patient presented with 3 years of progressive lymphocytosis. Cervical lymph node biopsy showed morphologic features of nodular MCL and internodular CLL/SLL, two populations of CD5+ cells by flow cytometry, a t(11;14) translocation with a deletion in chromosome 11 by FISH, and biclonal IGH gene rearrangement. In the peripheral blood, flow cytometry showed a single population of CD5+ cells; FISH showed a t(11;14) translocation. Peripheral blood IGH gene rearrangement confirmed a single B cell monoclonal population identical to one of the two lymph node clones. Peripheral blood karyotyping detected 17p deletion, attributed to the MCL, the sole B cell clonal population in the peripheral blood. The diagnosis was concurrent MCL and CLL/SLL in the lymph node with peripheral MCL harboring a 17p deletion. &nbsp