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Obesity could be associated with enhanced platelet (PL) function and thrombosis. Also, changes in gut microbiota composition were observed in obese patients, and probiotics supplementation has been shown to improve some of the obesity-associated metabolic parameters. This study aimed to determine the possible effects of probiotic supplementation on platelet morphology in overweight/obese premenopausal women.Twenty overweight (BMI = 25.0-29.9 kg/m2) and obese (BMI ≥ 30.0 kg/m2) women participated in double- blind, randomized, placebo-controlled study. They were randomly assigned to receive one capsule daily of probiotics (7x1010 CFU Lactobacillus plantarum 299v (DSM9843), 5x109 CFU Saccharomyces cerevisiae var. boulardii and 40mg octacosanol; N=10) or placebo (N=10) for 3 months. To determine changes in the parameters of platelet activation - the platelet count (PC), platelet distribution width (PDW), Feret diameter, and hypogranular appearance, blood samples were obtained for an automated hematology analyser and peripheral smears staining. Although difference in PC was not found between groups, supplementation with probiotics decreased PDW compared to the placebo group (p

Synchronous lectures tend to be used as the prevalent method of online instruction, irrespective of notable differences and obvious limitations when compared to their in-person delivery. Study aim was to assess students’ perspective on online lectures held during the emergency remote teaching (ERT) due to COVID-19 pandemic. Method: Students were invited to take part in online survey related to their experience with ERT. Survey included 25 items related to: satisfaction (14 items), motivation (3 items), interaction with peers and lecturers (4 items), and perceived challenges (4 items). A 5-point Likert scale was employed. Statistical analysis was performed using the SPSS software. Results: A total of 387 students participated in the survey. Majority of respondents (79.3%) were junior students. Among them, 72.6% reported no previous experience with online learning. Although relatively high level of satisfaction was reported (mean score 3.91±0.75), challenges were also scored relatively high (3.05±0.99), while interaction was scored somewhat lower (2.98±0.73), and the least mean score was observed for motivation (2.73±0.58). Students reported having trouble to keep motivation, concentration and focus during online lectures, which usually took long hours per day. Interaction with peers was reported as unsatisfactory (2.48±1.46), whereas it was more feasible with lecturers (3.24±1.42). Students were quite satisfied with the possibility to organize their time flexibly (71.4%), and with respect to the workload (54.5%), while they were less convinced that online sessions provide enough opportunities to reflect on what has been learnt (50,1% agree, 25,1% neither agree nor disagree). Conclusions: The results obtained indicate that students are somewhat hesitant with respect to online lectures as the main mode of instruction. Lectures, generally, place students in a passive role, which is further increased in online delivery. In order to support students’ engagement and success, online lectures should be combined with more active instructional strategies. ORAL PREVIEW (usmena prezentacija) Link to the Pharmacy Education version [https://farfar.pharmacy.bg.ac.rs/handle/123456789/4381]

Many types of vegetable oils produce around the world. They are useful in nutrition, prevention and treatment of diseases. Some oils traditionally have been well known for a long time and have been shown many potential health benefits, such as, cardioprotective effect, effect on digestion, risk of some cancer and it is also used in the treatment of skin infections. This work was conducted to study some quality criteria of oil extracted from seven different raw seeds purchased in the Serbian market, namely: sunflowers, sesame seeds, black sesame seeds, tickles seeds, chia seeds, flax seeds and hemp seeds. Oils are essentially regarded in terms of quality based on their free fatty acid, iodine value and peroxides value. Oils were extracted from the seeds by cold extraction with petroleum ether. Quality characteristics, such as refractive index, acid value, peroxide value, iodine value and saponification value and unsaponifiable matter were determined. For the determination of these parameters, official methods (ISO 6320; ISO660; ISO 3960; ISO 3961; ISO 3657 and ISO 18609, respectively) were used. The contents of investigated parameters in seed samples were determined in the range of 1.467 to 1.485 nD for refractive index; 1.62 to 4.95 mg KOH/g for acid value; 5.21 to 7.45 for peroxide value; 118 to 197 for iodine value; 180 to 193 for saponification value and 3.14 to 7.26 g/kg for the unsaponifiable matter. Data obtained in this investigation indicate that all quality parameters of the seed samples, except peroxide value , comply with the national and Codex standards. 10th International Congress of Food Technologists, Biotechnologists and Nutritionists, 30.11-2.12.2022. Zagreb, Croatia

Although it is considered that optimal nutrition could provide all essential nutrients and active compounds, various dietary regimes are often not following the relevant recommendations. On the contrary, nutritional status is closely related to the immune system. Namely, insufficient caloric intake or a lack of a nutrient can primarily weaken the immune response. The gastrointestinal tract plays an essential role in the function of the immune system, which is both the place of absorption of nutrients and the body's immune defence. Globally, the most prominent cause of immunodeficiencies is undernutrition and starvation, up to 50 % of undeveloped countries' populations. Undernutrition negatively affects both innate and adaptive immunity; considering these facts, it is clear that a prolonged low caloric intake could affect immunity adversely. Since the sixties, World Health Organisation has considered relations between nutrition and immunity, and nutritional immunology is a newer scientific discipline. Later, the precise relationship between low protein intake and lymphoid tissue involution was defined. Generally, the deficiencies of energy, proteins, iron, iodine, vitamin A, zinc and calcium are the most common. It is estimated that every third person is being affected globally. Prolonged hypercaloric intake and resulting obesity could also exhibit immunocompromising effects through inflammation and hyperactivation of the immune system. The negative impact on the immune system could also be provoked by intense physical activity, infective agents, and emotional stress. Iako se stručna javnost slaže da se odgovarajući unos nutrijenata može obezbediti dobro izbalansiranom ishranom, u opštoj populaciji su zastupljeni različiti režimi ishrane koji u potpunosti ne slede preporuke relevantnih tela. Sa druge strane, nutritivni status je u bliskoj vezi sa imunskim sistemom. Naime, nedovoljan kalorijski unos ili nedostatak nekog nutrijenta prvenstveno može dovesti do slabljenja imunskog odgovora. Važnu ulogu u funkciji imunskog sistema ima i gastrointestinalni trakt koji predstavlja mesto apsopcije nutrijenata, ali i imunološke odbrane organizma. Najčešć i uzrok imunodeficijencije u svetu je pothranjenost. i to kod čak 50% stanovništva u zemljama trećeg sveta. Pothranjenost dovodi do poremećaja i urođenog i stečenog imunskog odgovora. Imajući u vidu ove činjenice, jasno se nameće zaključak da dugotrajni režimi smanjenog kalorijskog unosa mogu ispoljiti sličan efekat. Nutritivna imunologija je relativno mlada naučna disciplina koja se bavi ovom problematikom, a šezdesetih godina izlazi monografija Svetske zdravstvene organizacije na ovu temu. Sedamdesetih je uspostavljena jasna veza izmedju proteinske malnutricije i involucije limfoidnog tkiva, pa i timusa. Globalno, među najzastupljenijijim deficitima su deficit energetskog unosa, proteina, gvožđa, joda, vitamina A, D, cinka i kalcijuma, a procena je da je svaka treća osoba u svetu pogođena nekim od nutritivnih deficita. Dugotrajan prekomeran kalorijski unos kao i posledična gojaznost, takođe mogu ispoljiti imunokompromitujući efekat i to kroz inflamaciju, kao i hiperaktivaciju imunskog odgovora. Negativan efekat na imunski sistem mogu imati i veoma intenzivan fizički napor, kao i psihički stress, i različiti infektivni agensi. VIII Kongres farmaceuta Srbije sa međunarodnim učešćem, 12-15.10.2022. Beograd

Introduction: Synchronous lectures tend to be used as the prevalent method of online instruction, irrespective of notable differences and obvious limitations when compared to their in-person delivery. Study aim was to assess students’ perspective on online lectures held during the emergency remote teaching (ERT) shift due to the COVID-19 pandemic. Method: Students were invited to take part in online survey related to their experience with ERT. Survey included 25 items related to: satisfaction (14 items), motivation (three items), interaction with peers and lecturers (four items), and perceived challenges (four items). A 5-point Likert scale was employed. Statistical analysis was performed using the SPSS software. Results: A total of 387 students participated in the survey. The majority of respondents (79.3%) were junior students. Among the respondents, 72.6% reported no previous experience with online learning. Although a relatively high level of satisfaction was reported (mean score 3.91 ± 0.75), challenges were also scored relatively high (3.05 ± 0.99), while interaction was scored somewhat lower (2.98 ± 0.73), and the lowest mean score was observed for motivation (2.73 ± 0.58). Students reported having trouble maintaining motivation, concentration and focus during online lectures, which usually took many hours per day. Interaction with peers was reported as unsatisfactory (2.48 ± 1.46), whereas it was more feasible with lecturers (3.24 ± 1.42). Students were quite satisfied with the ability to organise their time flexibly (71.4%), and with the workload (54.5%), while they were less convinced that online sessions provided enough opportunities to reflect on what was learnt (50.1% agree, 25.1% neither agree nor disagree). Conclusions: The results obtained indicate that students are somewhat hesitant with respect to online lectures as the main mode of instruction. Lectures, generally, place students in a passive role, which is further increased in online delivery. In order to support students’ engagement and success, online lectures should be combined with more active instructional strategies. European Association of Faculties of Pharmacy (EAFP) Conference Proceedings 2022: Towards Pharmacy 5.0 Education Link to the Abstract book version [https://farfar.pharmacy.bg.ac.rs/handle/123456789/4375]

Fruits of Lycium barbarum L. (Solanaceae), known as wolfberries or goji berries, have been long used in traditional medicine and nutrition in Asian countries. However, in recent years, they have become popular in Europe, including Serbia. However, there are limited data on the chemical composition of goji berries cultivated in our country. This study aimed to estimate and perform a comparative analysis of the mineral content of goji berries from six locations in Serbia. After microwave digestion, macro- (K, Na, P, S, Mg, Ca) and microelement (Fe, Zn, Cu, Cr, Mn, Mo) contents in analyzed samples were determined by the optical emission spectrometry with induced coupled plasma (ICP-OES). As expected, mineral concentrations varied significantly among goji berry samples from different locations (p < 0.05). In general, the decreasing orders of minerals in goji berries were: K > P > S > Na > Mg > Ca > Zn > Fe > Cu > Mn > Cr > Mo. According to the Recommended Daily Allowance (RDA) values, dried goji berries (30 g) provide a rich source of Cr and Cu, while their contribution to the daily intake of other minerals was below 15% RDA. Plodovi Lycium barbarum L. (Solanaceae), poznatiji kao vučje bobice ili godži, imaju dugu istoriju upotrebe u tradicionalnoj medicini i ishrani stanovnika azijskih zemalja, a poslednjih godina su sve popularniji u Evropi, uključujući i Srbiju. Međutim, nema mnogo podataka o hemijskom sastavu plodova godži gajenih u našoj zemlji. Cilj ovog rada je bio da se izvrši komparativna analiza mineralnog sastava plodova godži prikupljenih sa šest različitih lokacija u Srbiji. Nakon prethodne mikrotalasne digestije, sadržaj makro- (K, Na, P, S, Mg, Ca) i mikroelemenata (Fe, Zn, Cu, Cr, Mn, Mo) u ispitivanim uzorcima suvih plodova godži, određen je primenom optičke emisione spektrometrije sa indukovano spregnutom plazmom (ICP-OES). Kao što je i očekivano, dobijeni rezultati ukazuju na statistički značajne razlike u sadržaju mineralnih materija u plodovima godži prikupljenih sa različitih lokacija (p < 0,05). Generalno, mineralne materije su zastupljene po sledećem opadajućem redosledu koncentracija: K > P > S > Na > Mg > Ca > Zn > Fe > Cu > Mn > Cr > Mo. Utvrđeni sadržaj makro- i mikroelemenata u jednoj porciji (30 g suvih plodova godži), u odnosu na nutritivne referentne vrednosti (NRV), ukazuje da su plodovi godži bogat izvor Cr i Cu, dok je doprinos jedne porcije plodova godži dnevnom unosu ostalih mineralnih materija ispod 15% NRV. VIII Kongres farmaceuta Srbije sa međunarodnim učešćem, 12-15.10.2022. Beograd

Prema definiciji Svetske Zdravstvene Organizacije, probiotici su živi mikroorganizmi koji kada su konzumirani u adekvatnoj količini imaju povoljne efekte na zdravlje domaćina. Pod pojmom probiotskih bakterija misli se većinom na bakterije mlečne kiseline (BMK) koje obuhvataju uglavnom vrste iz rodova Lactobacillus i Bifidobacterium. Rastući je broj dokaza koji ukazuju da primena BMK može ispoljiti povoljne efekte u tretmanu komponenata metaboličkog sindroma, kao što su gojaznost, dijabetes tip 2, dislipidemije, nealkoholna masna bolest jetre (engl. Nonalcoholic Fatty Liver Disease, NAFLD). NAFLD obuhvata čitav spektar oboljenja, počev od hepatične steatoze preko nealkoholnog steatohepatitisa do hepatične fibroze. Predstavlja najčešći uzrok ozbiljnih i hroničnih oboljenja jetre kod odraslih i kod dece u zapadnim zemljama, sa prevalencom od 20-30% u opštoj odrasloj populaciji, pri čemu prevalenca korelira sa povećanom incidencom gojaznosti i metaboličkog sindroma. Nedavno objavljena istraživanja ukazuju na ulogu crevne mikrobiote u razvoju steatoze i progresiji NAFLD-a, a s obzirom da probiotici mogu delovati na više nivoa na patogenezu oboljenja, a uz to su još i bezbedni i pristupačni, nije iznenađujuće što LAB postaju sve privlačniji kao potencijalna dugoročna terapija NAFLDa. Kliničke i eksperimentalne studije sugerišu da se probiotici značajno razlikuju u efektima i mehanizmima dejstva a razlike postoje, ne samo između različitih vrsta, već i između različitih soje iste vrste. Zbog toga je najvažniji cilj ove studije bio da se razvije model NAFLD (stadijum steatoze) ishranom visokog sadržaja masti (VSM), a zatim da se ispita i izvrši poređenje dejstva oralne primene dva različita soja BMK, Lactobacillus rhamnosus LA68 i Lactobacillus plantarum WCFS1, na imunološke i metaboličke parametre, na razvoj steatoze, kao i na sastav masnih kiselina organa kod miševa soja C57BL/6 u uslovima VSM ishrane. Nakon 16 nedelja VSM ishrane, u kojoj je 41% energije poticao od masti, kod miševa soja C57BL/6 došlo je do značajnog porasta telesne mase, i razvoja steatoze koju je pratio poremećaj lipidnih parametara i porast nivoa leptina, što odgovara početnoj fazi NAFLD (stadijum steatoze)... According to the World Health Organisation's definition, probiotics are alive microorganisms which, when consumed in adequate quantities, have beneficial effects on host's health. The term probiotics bacteria mostly refers to lactic acid bacteria (LAB) which include species from the genera Lactobacillus and Bifidobacteria. The increasing amount of evidence indicates that the usage of LAB can have positive effects on the treatment of metabolic syndrome components, such as: obesity, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease (NAFLD). NAFLD includes a whole spectar of diseases, starting from hepatic steatosis through nonalcoholic steatohepatitis to hepatic fibrosis which may further progress into ireversibile cirrhosis and hepatocellular carcinoma. NAFLD represents the most common cause of severe and chronic liver diseases in adults and children in Western countres, with the prevelance correlating with increased incidence of obesity and metabolic syndrome. Recently published research points to the role of intestinal microbiota in the development of steatosis and progression of NAFLD. Probiotics, especially LAB, can have an influence on disease pathogenesis at multiple levels and besides that they are safe and affordable. Taking into account all abovementioned reasons, it is not surprising that LAB are becoming more and more attractive as potential long-term NAFLD therapy. Clinical and experimental studies suggest that LAB differ significantly in the effects and mechanisms of action. Those differences are not only among different species but also among different strains within the same species. Because of that, the most important goal of this study was to develop a model of NAFLD (steatosis stadium) with use of high fat diet (HFD) and then to examine and to compare the effects of oral administration of two different LAB species/strains, Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1, on immunological and metabolic parameters, on steatosis development status, as well as on fatty acid composition of liver and brain in C57BL/6 mice under high fat diet regime...

Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13–15, 2015

Introduction: It is well known that long-term and regular intakes of long chain (LC) n-3 polyunsaturated fatty acids (PUFAs) from fish or fish oil supplements are useful in improving n-3 fatty status. Dietary guidelines recommend use of these fatty acids in purpose of cardio- vascular primary and secondary preventions. Objectives: The objective of this study was to explore the difference in plasma fatty acid profile following general recommendations for fish intake or fish oil supplement usage. Method / Design: Participants were randomised to receive salmon (oily fish) providing 274 mg EPA + 671 mg DHA/day or commercial fish oil supplement providing 396 mg EPA + 250 mg DHA/ day in cross-over trial over 8 weeks period separated by the 6 months washout period. Fatty acids were extracted from plasma and analysed by gas chromatography. Results: The initial plasma concentration of fatty acids was not different between groups at baseline and after the washout phase. After 8 weeks, there was a significant increase in the level of EPA, DHA and total n-3 fatty acids in plasma of both groups. The percentage values of EPA increased by 135% in salmon group (p

11th European Nutrition Conference (FENS), Madrid, Spain, October 26–29, 2011

Увод: Декларисање намирница представља њено означавање словном ознаком, робним знаком или симболом, а налази се на амбалажи, етикети или омоту намирнице. Међу факторима који доприносе порасту инциденце незаразних болести се налазе нездрава исхрана и неразумевање улоге хране у очувању здравља. Циљ рада: Свеобухватно испитати ставове, знања и навике у популацији студената о разумевању и коришћењу информација на декларацијама прехрамбених производа у избору намирница. Материјал и методе: За ово истраживање је креиран онлајн упитник који је дистрибуиран путем друштвене мреже Facebook и апликација Viber и WhatsApp и који је попунило 124 испитаника. Подаци су обрађени у програму Microsoft Excel 2013. Резултати: Изражен став испитаници су показали на тврдње везане за основна знања када је у питању разумевање информација са декларација производа. Информације о садржају шећера, масти и соли на декларацији производа могу бити корисне потрошачима у смањењу ризика за развој незаразних болести. Испитаници највише обраћају пажњу на количину угљених хидрата (31,1%), протеина (11,5%) и на број калорија (29,5%). Декларације свакодневно чита 24,2% испитаника. Испитаници су показали висок ниво знања у препознавању здравствених (70,7%) и нутритивних изјава (65,9%), као и жељу за додатном едукацијом (75,8%). Закључак: Велики број испитаника увиђа значај коришћења информација са декларација прехрамбених производа, показује адекватно знање, чита нутритивне декларације, мање обраћа пажњу на бренд и жели додатно да се едукује. Introduction: Food labeling represents marking with letter mark, trademark or symbol, which is found on packaging, food label (label) or wrapper. Among the factors that contribute to increase in incidence of non-communicable diseases are unhealthy diet and misunderstanding of the role of food in maintaining health. The Aim: Comprehensive examination attitudes, habits and knowledge of biomedical science students about understanding and use of information on labels when choosing foodstuffs. Material and Methods: An online questionnaire was created for this research, which was distributed via social network Facebook, applications Viber and WhatsApp and was filled out by 124 respondents. Data were processed in Microsoft Excel 2013. Results: Respondents expressed a strong attitude to claims related to basic knowledge when it comes to understanding information from labels. Information on content of sugar, fat and salt on product label may be useful to consumers in reducing risk of non-communicable diseases development. Respondents pay the most attention to amount of carbohydrates (31.1%), protein (11.5%) and number of calories (29.5%). Labels are read daily by 24.2% of respondents. Respondents showed high level of knowledge in recognizing health (70.7%) and nutritional statements (65.9%), as well as desire for additional education (75.8%). Conclusion: Major respondents recognize importance of using information from labels, show adequate knowledge, read labels, pay less attention to the brand and want to be further educated.

Језграсто воће и њихова уља су богата моно- и полинезасићеним масним киселинама. Nuts and their oils are rich in mono- and polyunsaturated fatty acids.