1. Evaluation of BNT162b2 vaccine effectiveness in Malaysia: test negative case-control study
- Author
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Audrey Huili Lim, Norazida Ab Rahman, Su Miin Ong, Jubaida Paraja, Rahmah Rashid, Ishvinder Singh Parmar, Siti Nadiah Dahlan, Zhi Shan Sujata Tan, Ismuni Bohari, Kalaiarasu M. Peariasamy, and Sheamini Sivasampu
- Subjects
Vaccine effectiveness ,Adult ,Test-negative ,COVID-19 Vaccines ,Adolescent ,General Veterinary ,General Immunology and Microbiology ,SARS-CoV-2 ,Malaysia ,Public Health, Environmental and Occupational Health ,COVID-19 ,Vaccine Efficacy ,LMIC ,Infectious Diseases ,Case-Control Studies ,Humans ,Molecular Medicine ,BNT162b2 ,Case Control ,BNT162 Vaccine - Abstract
There is a notable lack of vaccine effectiveness studies using test-negative case-controlled approach in low- and middle-income countries which have different logistic, demographic and socio-economic conditions from high-income countries. We aimed to estimate the effectiveness of BNT162b2 vaccine against COVID-19 infection over time, intensive care unit admission, severe or critical disease and death due to COVID-19. This study was conducted in the resident population of Labuan aged ≥18years who had been tested for SARS-CoV-2 by Reverse-Transcriptase Polymerase Chain Reaction between 1 March 2021 and 31 October 2021. We used a test-negative case-control design where 2644 pairs of cases and controls were matched by age, sex, testing date, nationality and testing reason. Analysis was stratified by age group to estimate age effect (
- Published
- 2022
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