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117 results on '"Ishida, Tadashi"'

16. Development and validation of a new scoring system for prognostic prediction of community-acquired pneumonia in older adults

Author

Shirata, Masahiro, Ito, Isao, Ishida, Tadashi, Tachibana, Hiromasa, Tanabe, Naoya, Konishi, Satoshi, Oi, Issei, Hamao, Nobuyoshi, Nishioka, Kensuke, Matsumoto, Hisako, Yasutomo, Yoshiro, Kadowaki, Seizo, Ohnishi, Hisashi, Tomioka, Hiromi, Nishimura, Takashi, Hasegawa, Yoshinori, Nakagawa, Atsushi, and Hirai, Toyohiro

Subjects
Aged, 80 and over, Male, Multidisciplinary, Science, Pneumonia, Article, Blood Urea Nitrogen, Community-Acquired Infections, Bedridden Persons, Prognostic markers, Humans, Medicine, Female, Mortality, Bacterial infection, Confusion, Hypoxia, Serum Albumin, Aged
Abstract

The discriminative power of CURB-65 for mortality in community-acquired pneumonia (CAP) is suspected to decrease with age. However, a useful prognostic prediction model for older patients with CAP has not been established. This study aimed to develop and validate a new scoring system for predicting mortality in older patients with CAP. We recruited two prospective cohorts including patients aged ≥ 65 years and hospitalized with CAP. In the derivation (n = 872) and validation cohorts (n = 1,158), the average age was 82.0 and 80.6 years and the 30-day mortality rate was 7.6% (n = 66) and 7.4% (n = 86), respectively. A new scoring system was developed based on factors associated with 30-day mortality, identified by multivariate analysis in the derivation cohort. This scoring system named CHUBA comprised five variables: confusion, hypoxemia (SpO2 ≤ 90% or PaO2 ≤ 60 mmHg), blood urea nitrogen ≥ 30 mg/dL, bedridden state, and serum albumin level ≤ 3.0 g/dL. With regard to 30-day mortality, the area under the receiver operating characteristic curve for CURB-65 and CHUBA was 0.672 (95% confidence interval, 0.607–0.732) and 0.809 (95% confidence interval, 0.751–0.856; P

Published
2021

24. Additional file 2 of Clinical factors associated with shorter durable response, and patterns of acquired resistance to first-line pembrolizumab monotherapy in PD-L1-positive non-small-cell lung cancer patients: a retrospective multicenter study

Author

Hosoya, Kazutaka, Fujimoto, Daichi, Morimoto, Takeshi, Kumagai, Toru, Tamiya, Akihiro, Taniguchi, Yoshihiko, Yokoyama, Toshihide, Ishida, Tadashi, Matsumoto, Hirotaka, Hirano, Katsuya, Kominami, Ryota, Tomii, Keisuke, Suzuki, Hidekazu, Hirashima, Tomonori, Tanaka, Satoshi, Uchida, Junji, Morita, Mitsunori, Kanazu, Masaki, Mori, Masahide, Nagata, Kenji, Fukuda, Ikue, and Tamiya, Motohiro

Abstract

Additional file 2 Supplementary Fig. 1. Progression-free survival (A) and overall survival (B) in all patients who received first-line pembrolizumab. Generated using JMP software (version 14; SAS Institute, Cary, NC, USA). Supplementary Fig. 2. Flow chart of the study patients. Supplementary Fig. 3. Progression-free survival (PFS) in patients with response, stratified by sex (A), smoking history (B), histology (C), stage (D), and presence of pleural effusion or dissemination (E), brain metastasis (F), adrenal grand metastasis (G), liver metastasis (H), early immune-related adverse events (irAEs) (I). Generated using JMP software (version 14; SAS Institute, Cary, NC, USA). Supplementary Fig. 4. Pie-chart summarizing the organs with progressive lesions. Patients with progression in one organ (blue), 2 organs (orange), or 3 or more organs (grey). Supplementary Fig. 5. The 2nd progression-free survival of patients who developed acquired resistance, received local ablative therapy and pembrolizumab therapy beyond 1st PD. Generated using JMP software (version 14; SAS Institute, Cary, NC, USA).

Published
2021
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25. Additional file 1 of Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Chikatoshi Sugimoto, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Yutaro Nakamura, Suda, Takafumi, and Ishida, Tadashi

Abstract

Additional file 1: Table S1. Reasons for IIPs being unclassified in MDD.

Published
2021
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26. Additional file 1 of Clinical factors associated with shorter durable response, and patterns of acquired resistance to first-line pembrolizumab monotherapy in PD-L1-positive non-small-cell lung cancer patients: a retrospective multicenter study

Author

Hosoya, Kazutaka, Fujimoto, Daichi, Morimoto, Takeshi, Kumagai, Toru, Tamiya, Akihiro, Taniguchi, Yoshihiko, Yokoyama, Toshihide, Ishida, Tadashi, Matsumoto, Hirotaka, Hirano, Katsuya, Kominami, Ryota, Tomii, Keisuke, Suzuki, Hidekazu, Hirashima, Tomonori, Tanaka, Satoshi, Uchida, Junji, Morita, Mitsunori, Kanazu, Masaki, Mori, Masahide, Nagata, Kenji, Fukuda, Ikue, and Tamiya, Motohiro

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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27. Additional file 3 of Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Chikatoshi Sugimoto, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Yutaro Nakamura, Suda, Takafumi, and Ishida, Tadashi

Abstract

Additional file 3: Fig. S1. Correlation between BAL lymphocytes and interstitial cell infiltration on histopathological examination in a subgroup of patients without anti-inflammatory drugs.

Published
2021
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28. Additional file 4 of Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Chikatoshi Sugimoto, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Yutaro Nakamura, Suda, Takafumi, and Ishida, Tadashi

Abstract

Additional file 4: Fig. S2. Prognostic impact of BAL lymphocytosis on patients treated with anti-inflammatory drugs at each cut-off value

Published
2021
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29. Additional file 2 of Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Chikatoshi Sugimoto, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Yutaro Nakamura, Suda, Takafumi, and Ishida, Tadashi

Subjects
enzymes and coenzymes (carbohydrates), fungi, genetic processes, health occupations, environment and public health
Abstract

Additional file 2: Table S2. Environmental exposures, symptoms suggestive of CTD, and serologic markers associated with CTD

Published
2021
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30. Additional file 5 of Impact of bronchoalveolar lavage lymphocytosis on the effects of anti-inflammatory therapy in idiopathic non-specific interstitial pneumonia, idiopathic pleuroparenchymal fibroelastosis, and unclassifiable idiopathic interstitial pneumonia

Author

Yamagata, Akira, Arita, Machiko, Tachibana, Hiromasa, Tokioka, Fumiaki, Chikatoshi Sugimoto, Sumikawa, Hiromitsu, Tanaka, Tomonori, Yasui, Hideki, Fujisawa, Tomoyuki, Yutaro Nakamura, Suda, Takafumi, and Ishida, Tadashi

Abstract

Additional file 5: Fig. S3. CART analysis for predicting prognosis.

Published
2021
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31. Additional file 3 of Clinical factors associated with shorter durable response, and patterns of acquired resistance to first-line pembrolizumab monotherapy in PD-L1-positive non-small-cell lung cancer patients: a retrospective multicenter study

Author

Hosoya, Kazutaka, Fujimoto, Daichi, Morimoto, Takeshi, Kumagai, Toru, Tamiya, Akihiro, Taniguchi, Yoshihiko, Yokoyama, Toshihide, Ishida, Tadashi, Matsumoto, Hirotaka, Hirano, Katsuya, Kominami, Ryota, Tomii, Keisuke, Suzuki, Hidekazu, Hirashima, Tomonori, Tanaka, Satoshi, Uchida, Junji, Morita, Mitsunori, Kanazu, Masaki, Mori, Masahide, Nagata, Kenji, Fukuda, Ikue, and Tamiya, Motohiro

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2021
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45. Additional file 1: of Prognostic significance of crazy paving ground grass opacities in non-HIV Pneumocystis jirovecii pneumonia: an observational cohort study

Author

Kumagai, Shogo, Arita, Machiko, Koyama, Takashi, Kumazawa, Takao, Inoue, Daiki, Nakagawa, Atsushi, Kaji, Yusuke, Furuta, Kenjiro, Motonari Fukui, Tomii, Keisuke, Taguchi, Yoshio, Tomioka, Hiromi, and Ishida, Tadashi

Abstract

Table S1. Univariate analysis for mortality. A univariate Cox regression analyses were employed to identify significant prognostic factors. (DOCX 15 kb)

Published
2019
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