346 results on '"In-Ho Paik"'
Search Results
2. Orthodontic retreatment for vertical control in a patient with skeletal Class II long face
- Author
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Cheol-Ho Paik, Hyo-Won Ahn, Hobeen Yu, and Jae Hyun Park
- Subjects
General Medicine - Published
- 2023
3. Distinct and overlapping features of nodal peripheral T-cell lymphomas exhibiting a follicular helper T-cell phenotype: a multicenter study emphasizing the clinicopathological significance of follicular helper T-cell marker expression
- Author
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Jin Ho Paik, Jiwon Koh, Bogyeong Han, Sehui Kim, Ki Rim Lee, Sejoon Lee, Jeong-Ok Lee, Tae Min Kim, Wook Youn Kim, and Yoon Kyung Jeon
- Subjects
Pathology and Forensic Medicine - Abstract
Nodal peripheral T-cell lymphoma (PTCL) is a heterogeneous category including angioimmunoblastic T-cell lymphoma (AITL), PTCL of follicular helper T-cell (Tfh) phenotype (PTCL-Tfh), and PTCL, not otherwise specified (PTCL-NOS). We explored Tfh marker profiles in nodal PTCL. Nodal PTCLs (n=129) were reclassified into AITL [58%; 75/129], PTCL-Tfh [26%; 34/129] and PTCL-NOS [16%; 20/129]. Histologically, clear cell clusters, high endothelial venules, follicular dendritic cell proliferation, EBV+ cells and Hodgkin-Reed-Sternberg (HRS)-like cells were more common in AITL than PTCL-Tfh (HRS-like cells, p=0.005; otherwise, p0.001) and PTCL-NOS (HRS-like cells, p=0.028; otherwise, p0.001). PTCL-NOS had a higher Ki-67 index than AITL (p=0.001) and PTCL-Tfh (p=0.002). Clinically, AITL had frequent B symptoms (vs. PTCL-Tfh, p=0.010), while PTCL-NOS exhibited low stage (vs. AITL+PTCL-Tfh, p=0.036). Positive Tfh markers were greater in AITL (3.5±1.1) than PTCL-Tfh (2.9±0.9; p=0.006) and PTCL-NOS (0.5±0.5; p0.001). Tfh markers showed close correlations among them and AITL-defining histology. By clustering analysis, AITL and PTCL-NOS were relatively exclusively clustered, while PTCL-Tfh overlapped with them. Survival was not different among the PTCL entities. By Cox regression, sex and ECOG performance status (PS) independently predicted shorter progression-free survival in the whole cohort (male, p=rmfl0.001, HR=2.5; PS≥2, p=0.010, HR=1.9) and in 'Tfh-lymphomas' (i.e., AITL+PTCL-Tfh) (male, p=0.001, HR=2.6; PS≥2, p=0.016, HR=2.1), while only PS predicted shorter overall survival (OS) in the whole cohort (p=0.012, HR=2.7) and in 'Tfh-lymphomas' (p=0.001; HR=3.2). ICOS predicted favorable OS in 'Tfh-lymphomas' (log-rank; p=0.016). Despite the overlapping features, nodal PTCL entities could be characterized by Tfh markers revealing clinicopathologic implications.
- Published
- 2023
4. NIRS Data Augmentation Technique to Detect Hemodynamic Peaks During Self-Paced Motor Imagery
- Author
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Zephaniah Phillips Ⅴ, Seung-Ho Paik, Seung-Hyun Lee, Eun-Jeong Choi, and Beop-Min Kim
- Subjects
General Computer Science ,General Engineering ,General Materials Science ,Electrical and Electronic Engineering - Published
- 2023
5. Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with RUNX1::RUNX1T1
- Author
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Sang Mee Hwang, Beom Joon Kim, Jee-Soo Lee, Moon-Woo Seong, Soo Hyun Seo, Jin Ho Paik, Sang-A Kim, Ji Yun Lee, Jeong-Ok Lee, Yoon Hwan Chang, and Soo Mee Bang
- Subjects
Biochemistry (medical) ,Clinical Biochemistry ,General Medicine - Published
- 2022
6. A Study on the Making of Game Character Costume Focused on 'Icon' of Peirce’s Semiotics
- Author
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Hyo-Jin Kim and Chul-Ho Paik
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- 2022
7. Pediatric-Type Indolent B-Cell Lymphomas With Overlapping Clinical, Pathologic, and Genetic Features
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Sojung Lim, Ka Young Lim, Jiwon Koh, Jeong Mo Bae, Hongseok Yun, Cheol Lee, Young A. Kim, Jin Ho Paik, and Yoon Kyung Jeon
- Subjects
Adult ,Male ,Lymphoma, B-Cell ,Adolescent ,Lymphoma, B-Cell, Marginal Zone ,Middle Aged ,Pathology and Forensic Medicine ,Young Adult ,Child, Preschool ,Interferon Regulatory Factors ,Mutation ,Humans ,Female ,Surgery ,Anatomy ,Child ,Lymphoma, Follicular - Abstract
Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone lymphoma (PNMZL) are rare pediatric-type indolent B-cell lymphomas (PedIBCL) that differ clinicopathologically from their adult counterparts. Accurate diagnosis is important to avoid overtreatment but is often challenging. The mutational landscape of PTFL is known and may aid diagnosis, but the genetic features of PNMZL are not well understood. We analyzed 21 cases of PedIBCL according to their clinicopathologic findings and classified them into PTFL (n=11), PNMZL (n=2), and "mixed type" tumors (n=8) showing ambiguous histology. We also analyzed 2 cases of adult B-cell lymphomas showing features of PedIBCL. Targeted sequencing of 121 lymphoma-related genes was performed. The median age of PedIBCL patients was 16 years (range: 3 to 47), and all but 1 PTFL patient were male. All patients presented with limited-stage disease, and only 1 relapsed. There were no significant differences in clinical features among the 3 PedIBCL groups. The most frequently mutated genes were MAP2K1 , TNFRSF14 , KMT2C , IRF8 , and NOTCH2 . The genetic features of all groups were similar to the established mutational landscape of PTFL. The 2 adult B-cell lymphomas cases also had MAP2K1 , TNFRSF14 , and IRF8 mutations, but the clinical features were not typical of PedIBCL. In summary, this study demonstrated that PTFL and PNMZL are similar diseases with overlapping clinical, pathologic, and genetic features; mixed type tumors can also occur. Atypical adult cases with similar histologic features were also observed. Therefore, the disease spectrum of PedIBCL may be much broader than is currently believed.
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- 2022
8. Genotype–phenotype correlation of X-linked Alport syndrome observed in both genders: a multicenter study in South Korea
- Author
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Ji Hyun Kim, Seon Hee Lim, Ji Yeon Song, Myung Hyun Cho, HyeSun Hyun, Eun Mi Yang, Jung Won Lee, Min Hyun Cho, Min Ji Park, Joo Hoon Lee, Jiwon Jung, Kee Hwan Yoo, Kyung Mi Jang, Ki Soo Pai, Jin-Soon Suh, Mee Kyung Namgoong, Woo Yeong Chung, Su Jin Kim, Eun Young Cho, Kyung Min Kim, Nam Hee Kim, Minsun Kim, Jin Ho Paik, Hee Gyung Kang, Yo Han Ahn, and Hae Il Cheong
- Subjects
Multidisciplinary - Abstract
The genotype–phenotype correlation of the X-linked Alport syndrome (XLAS) has been well elucidated in males, whereas it remains unclear in females. In this multicenter retrospective study, we analyzed the genotype–phenotype correlation in 216 Korean patients (male:female = 130:86) with XLAS between 2000 and 2021. The patients were divided into three groups according to their genotypes: the non-truncating group, the abnormal splicing group, and the truncating group. In male patients, approximately 60% developed kidney failure at the median age of 25.0 years, and kidney survival showed significant differences between the non-truncating and truncating groups (P P = 0.002, HR 3.1). Sensorineural hearing loss was detected in 65.1% of male patients, while hearing survival periods showed a highly significant difference between the non-truncating and truncating groups (P P = 0.006, HR 5.7). Our findings support the presence of genotype–phenotype correlation not only in male patients but also in female patients with XLAS.
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- 2023
9. Data from MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma
- Author
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Chul-Woo Kim, Dae Seog Heo, Tae Min Kim, Wook Youn Kim, Yoon Kyung Jeon, Ji-Young Jang, and Jin Ho Paik
- Abstract
Purpose: We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL).Experimental Design: We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines.Results: Multivariate analysis showed low miR-146a expression (P < 0.001; HR = 13.110), primary non–upper aerodigestive tract lesion (non-UAT; P = 0.008; HR = 5.376) and high International Prognostic Index (IPI; ≥3; P = 0.013; HR = 3.584) to be independent poor prognostic factors. miR-146a expression could subdivide UAT-NKTL into 2 prognostic groups, resulting in the following prognostic groups: (i) UATLow-146a, (ii) UATHigh-146a, and (iii) non-UAT. Compared with UATHigh-146a, UATLow-146a showed distinctively poor prognosis (P < 0.001; HR = 15.620), similar to the non-UAT group. In vitro, miR-146a overexpression in NKTL cell lines, SNK6 and YT, inhibited nuclear factor κB (NFκB) activity, suppressed cell proliferation, induced apoptosis, and enhanced chemosensitivity. TNF receptor–associated factor 6, a target of miR-146a and a known NFκB activator, was downregulated by miR-146a in SNK6 and YT cells. Promoter methylation of miR-146a gene was observed in SNK6 and YT cells, as well as in NKTL tissues with low miR-146a expression, and miR-146a expression was induced by the conversion of methylation status with a demethylating agent in SNK6 and YT cells.Conclusions: These results suggest that miR-146a might function as a potent tumor suppressor in NKTL and be useful for patient assessment and therapeutic targeting. Clin Cancer Res; 17(14); 4761–71. ©2011 AACR.
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- 2023
10. Supplementary Data from MicroRNA-146a Downregulates NFκB Activity via Targeting TRAF6 and Functions as a Tumor Suppressor Having Strong Prognostic Implications in NK/T Cell Lymphoma
- Author
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Chul-Woo Kim, Dae Seog Heo, Tae Min Kim, Wook Youn Kim, Yoon Kyung Jeon, Ji-Young Jang, and Jin Ho Paik
- Abstract
Supplementary Methods; Supplementary Tables S1-S2.
- Published
- 2023
11. Clinical application of functional near-infrared spectroscopy for burn assessment
- Author
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Yoo Hwan Kim, Seung-Ho Paik, Youngmin Kim, Jaechul Yoon, Yong Suk Cho, Dohern Kym, Jun Hur, Wook Chun, Beop-Min Kim, and Byung-Jo Kim
- Subjects
Histology ,Biomedical Engineering ,Bioengineering ,Biotechnology - Abstract
Significance: Early assessment of local tissue oxygen saturation is essential for clinicians to determine the burn wound severity.Background: We assessed the burn extent and depth in the skin of the extremities using a custom-built 36-channel functional near-infrared spectroscopy system in patients with burns.Methods: A total of nine patients with burns were analyzed in this study. All second-degree burns were categorized as superficial, intermediate, and deep burns; non-burned skin on the burned side; and healthy skin on the contralateral non-burned side. Hemodynamic tissue signals from functional near-infrared spectroscopy attached to the burn site were measured during fNIRS using a blood pressure cuff. A nerve conduction study was conducted to check for nerve damage.Results: All second-degree burns were categorized into superficial, intermediate, and deep burns; non-burned skin on the burned side and healthy skin on the contralateral non-burned side showed a significant difference distinguishable using functional near-infrared spectroscopy. Hemodynamic measurements using functional near-infrared spectroscopy were more consistent with the diagnosis of burns 1 week later than that of the degree of burns diagnosed visually at the time of admission.Conclusion: Functional near-infrared spectroscopy may help with the early judgment of burn extent and depth by reflecting differences in the oxygen saturation levels in the skin.
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- 2023
12. A Study on the time-space expression of narrative-based game background design : Focused on Chronotope
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Yu-Jin Park and Chul-Ho Paik
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- 2022
13. A Study on the Analysis of Differences between Factors in the Research Model of Identity Play
- Author
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PaulChul-Ho Paik
- Published
- 2022
14. Bcl-6-dependent risk stratification by nuclear expression of Peli1 in diffuse large B-cell lymphoma
- Author
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Ki Rim, Lee, Jeong-Ok, Lee, Jong Seok, Lee, and Jin Ho, Paik
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Oncology - Published
- 2022
15. R-MPV followed by high-dose chemotherapy with thiotepa-based and autologous stem cell transplantation for newly diagnosed primary central nervous system lymphoma: a single-center experience
- Author
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Jong Seok Lee, Soo Mee Bang, Yu Jung Kim, Koung Jin Suh, Jin Ho Paik, Jee Hyun Kim, Jin Won Kim, Jeong Ok Lee, Ji Won Kim, Keun-Wook Lee, Ji Yun Lee, and Se Hyun Kim
- Subjects
medicine.medical_specialty ,Chemotherapy ,Performance status ,business.industry ,medicine.medical_treatment ,Primary central nervous system lymphoma ,Induction chemotherapy ,Hematology ,ThioTEPA ,medicine.disease ,Procarbazine ,Surgery ,Autologous stem-cell transplantation ,Primary CNS lymphoma ,Medicine ,Original Article ,business ,Febrile neutropenia ,Consolidation ,Thiotepa ,medicine.drug - Abstract
BackgroundHigh-dose chemotherapy followed by autologous stem-cell transplantation (HDC–ASCT) as a consolidation treatment is a promising approach in eligible patients with newly diagnosed primary central nervous system lymphoma (PCNSL). This study sought to assess the safety and efficacy of initial methotrexate-based chemotherapy followed by consolidation HDC-ASCT with a thiotepa-based conditioning regimen in patients with newly diagnosed PCNSL. MethodsIn this retrospective analysis, 22 patients with newly diagnosed PCNSL received chemotherapy with rituximab, methotrexate, procarbazine, and vincristine (R-MPV). Those who showed a complete or partial response subsequently received consolidation HDC-ASCT with a thiotepa-based conditioning regimen and no radiotherapy. ResultsCharacteristics of the PCNSL patients included a median age of 57 years (range: 49–67 years), Eastern Cooperative Oncology Group performance status of grade 2 or more in 9.1%, elevated lactate dehydrogenase level in 26.3%, and involvement of multiple lesions in 72.1%. About 82% of patients received six cycles of induction chemotherapy, which was well-tolerated with excellent disease control. The rate of confirmed/or unconfirmed complete response increased from 45.5% in the interim to 81.8% before HDC-ASCT. With a median follow-up of 19.6 months (range: 7.5–56.5 months), the 2-year progression-free survival and overall survival estimates were 84% and 88%, respectively. There were no treatment-related deaths. Grade 3 toxicity was recorded in 90.9% after HDC-ASCT, and the most common grade 3 adverse event was febrile neutropenia without sepsis. ConclusionsThe discussed treatment approach appears feasible in patients with newly diagnosed PCNSL, yielding encouraging results.
- Published
- 2021
16. Therapy-Related Acute Myeloid Leukemia Diagnosed at Postmortem in a Long-term Survivor of Advanced Hepatocellular Carcinoma
- Author
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Ki Rim Lee, Jin Ho Paik, Soong Deok Lee, and Moon-Young Kim
- Abstract
Acute myeloid leukemia (AML) is a common hematologic malignancy with high mortality and a short survival period in adults. About 10% of these cases, called therapy-related AML, are reported to be the consequence of chemotherapy or radiotherapy of previous malignancy. In a clinical setting, this is usually diagnosed by peripheral blood smear or bone marrow biopsy by assessing the proportion of blasts. However, postmortem blood samples are not suitable for smear analysis because of hemolysis. Therefore, ancillary tests for identifying leukemic infiltration or related molecular change can provide an alternative diagnostic clue for AML. The deceased had been treated for 3 years for a combined type of hepatocellular carcinoma with multiple pulmonary metastases. Treatments included the resections of primary and metastatic tumors, chemotherapy, and radiotherapy, which prevented further progression of his cancer. One year after the last treatment, he suddenly collapsed without any specific symptoms and shortly died. The microscopic examination of the autopsy samples revealed extensive extramedullary infiltration of leukemia, which was confirmed as an AML by a series of ancillary immunohistochemical staining. This case illustrates both the importance of careful hematologic observation in cancer survivors and the necessity of a detailed medical diagnosis in a medicolegal autopsy.
- Published
- 2021
17. Clinicopathologic implication of PD-L1 gene alteration in primary adrenal diffuse large B cell lymphoma
- Author
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Jin Ho Paik, Yoon Kyung Jeon, Hyun Jung Kwon, Jiwon Koh, Ki Rim Lee, and Jeong Ok Lee
- Subjects
PD-L1 ,medicine.medical_specialty ,Histology ,Chromosomal translocation ,Diffuse large B cell lymphoma ,Gastroenterology ,Pathology and Forensic Medicine ,International Prognostic Index ,immune system diseases ,Internal medicine ,hemic and lymphatic diseases ,Pathology ,medicine ,RB1-214 ,neoplasms ,Survival analysis ,Adrenal gland ,medicine.diagnostic_test ,biology ,business.industry ,Malignant lymphoma ,medicine.disease ,B symptoms ,Gene Alteration ,biology.protein ,Original Article ,medicine.symptom ,business ,Diffuse large B-cell lymphoma ,Fluorescence in situ hybridization - Abstract
Background: Primary adrenal (PA) diffuse large B cell lymphoma (DLBCL) was previously reported as an aggressive subset of DLBCL, but its genetic features were not sufficiently characterized. From our previous study of DLBCL with programmed death-ligand 1 (PD-L1) gene alterations, we focused on PD-L1 gene alterations in PA-DLBCL with clinicopathologic implications. Methods: We performed fluorescence in situ hybridization for PD-L1 gene translocation and amplification in PA-DLBCL (n = 18) and comparatively analyzed clinicopathologic characteristics with systemic non-adrenal (NA)-DLBCL (n = 90). Results: PA-DLBCL harbored distinctive features (vs. NADLBCL), including high international prognostic index score (3–5) (72% [13/18] vs. 38% [34/90], p = .007), poor Eastern Cooperative Oncology Group performance score (≥ 2) (47% [7/15] vs. 11% [10/90], p = .003), elevated serum lactate dehydrogenase (LDH) (78% [14/18] vs. 51% [44/87], p = .035) and MUM1 expression (87% [13/15] vs. 60% [54/90], p = .047). Moreover, PA-DLBCL showed frequent PD-L1 gene alterations (vs. NA-DLBCL) (39% [7/18] vs. 6% [5/86], p = .001), including translocation (22% [4/18] vs. 3% [3/87], p = .016) and amplification (17% [3/18] vs. 2% [2/87], p = .034). Within the PA-DLBCL group, PD-L1 gene–altered cases (vs. non-altered cases) tended to have B symptoms (p = .145) and elevated LDH (p = .119) but less frequent bulky disease (≥ 10 cm) (p = .119). In the survival analysis, PA-DLBCL had a poor prognosis for overall survival (OS) and progression-free survival (PFS) (vs. NA-DLBCL; p = .014 and p = .004). Within the PA-DLBCL group, PD-L1 translocation was associated with shorter OS and PFS (p < .001 and p = .012). Conclusions: PA-DLBCL is a clinically aggressive and distinct subset of DLBCL with frequent PD-L1 gene alterations. PD-L1 gene translocation was associated with poor prognosis in PA-DLBCL.
- Published
- 2021
18. Prognostic Impact of the Immunoscore Based on Whole-Slide Image Analysis of CD3+ Tumor-Infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
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Bogyeong Han, Jeemin Yim, Sojung Lim, Sei Na, Cheol Lee, Tae Min Kim, Jin-Ho Paik, Sehui Kim, and Yoon Kyung Jeon
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Pathology and Forensic Medicine - Published
- 2023
19. Characterization of Kikuchi-Fujimoto Disease in Children and Risk Factors Associated with its Course
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Sujin Choi, Hyoung Soo Choi, Young Jin Ryu, Ji Young Kim, Jin Ho Paik, Soyeon Ahn, and Hyunju Lee
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Pediatrics, Perinatology and Child Health - Published
- 2023
20. New orthopedic and orthodontic treatment modality for adult patients with skeletal Class III malocclusion with insufficient maxillary incisor exposure
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Cheol-Ho Paik, Ki-Ho Park, and Jae Hyun Park
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Orthodontics ,medicine.medical_specialty ,Adult patients ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,General Medicine ,Skeletal class ,medicine.disease ,stomatognathic diseases ,stomatognathic system ,Treatment modality ,Maxillary incisor ,Maxilla ,Orthopedic surgery ,otorhinolaryngologic diseases ,medicine ,Malocclusion ,business - Abstract
This paper aims to offer a new orthopedic and orthodontic treatment modality for treating adult patients with mild-to-moderate skeletal Class III discrepancy and insufficient maxillary incisor exposure who reject orthognathic surgery. For Phase I treatment, a rapid palatal expansion or miniscrew-assisted rapid palatal expansion is activated on the maxilla, and a modified lip bumper is installed on the mandibular dentition. At night, a facemask with a forward and downward orthopedic force is applied, whereas during the day, modified lip bumper and intraoral heavy Class III elastics are used. During Phase II treatment, intraoral elastics from the miniscrews between the mandibular premolars to the hooks between the maxillary lateral incisors and canines are activated to increase the maxillary incisor showing. In addition, activating elastomeric chains between the mandibular miniscrews and hooks between the mandibular lateral incisors and canines, the whole mandibular dentition is distally moved, and the mandibular incisors are intruded. Orthopedic and orthodontic treatment using a facemask, modified lip bumper, and mandibular miniscrews is an efficient way to improve adult skeletal Class III malocclusion and deficient maxillary incisor exposure.
- Published
- 2021
21. Immunoglobulin G4-related Ophthalmic Disease of the Caruncle: A Case Report
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Gyeong Min, Lee, NamJu, Kim, and Jin Ho, Paik
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Ophthalmology ,Immunoglobulin G ,Humans ,Immunoglobulin G4-Related Disease ,Eye - Published
- 2022
22. Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with
- Author
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Sang Mee, Hwang, Beom Joon, Kim, Jee-Soo, Lee, Moon-Woo, Seong, Soo Hyun, Seo, Jin Ho, Paik, Sang-A, Kim, Ji Yun, Lee, Jeong-Ok, Lee, Yoon Hwan, Chang, and Soo Mee, Bang
- Subjects
Leukemia, Myeloid, Acute ,RUNX1 Translocation Partner 1 Protein ,Mastocytosis, Systemic ,Oncogene Proteins, Fusion ,Staining and Labeling ,Hematologic Neoplasms ,Core Binding Factor Alpha 2 Subunit ,Humans ,Mast Cells ,Immunohistochemistry - Abstract
Systemic mastocytosis with associated hematological neoplasm (SM-AHN) poses diagnostic challenges because of the coexistence of atypical mast cell proliferation and hematological neoplasms. We assessed the presence of SM-AHN in patients with acute myeloid leukemia (AML) with
- Published
- 2022
23. Suboptimal Maximum Likelihood Detection of Integer Carrier Frequency Offset for Digital Terrestrial Television Broadcasting System
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Young-Hwan You and Jong-Ho Paik
- Subjects
Computer science ,Orthogonal frequency-division multiplexing ,020206 networking & telecommunications ,02 engineering and technology ,Signal ,Multiplexing ,Digital multimedia broadcasting ,Transmission (telecommunications) ,Modulation ,Carrier frequency offset ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,Electronic engineering ,Electrical and Electronic Engineering ,Decoding methods - Abstract
The integrated services digital broadcasting-terrestrial (ISDB-T) system adopts band segmented transmission orthogonal frequency division multiplexing (BST-OFDM) to support different services using hierarchical transmission. In the ISDB-T system, in particular, a hierarchical configuration depends on modulation type used in OFDM segment, which has to be decoded at the receiver. Therefore, it is necessary to detect integer carrier frequency offset (IFO) before decoding the modulation type carried through transmission and multiplexing configuration control (TMCC) signal. To address this issue, an effective IFO estimation scheme is presented for the ISDB-T system, considering information-carrying TMCC signal as pilot symbol without any need of additional pilots. In order to verify the performance of the proposed estimation scheme, theoretical detection error rate is derived. It is shown from simulation results that the redundantly transmitted TMCC signal can be efficiently utilized for IFO detection, offering an approximate performance of maximum likelihood detection.
- Published
- 2020
24. Structualized Process Research of Efficiency in Background Concept Art Production
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Paul Chul-ho Paik and Kim Ju-min
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Engineering ,business.industry ,Process research ,Production (economics) ,business ,Concept art ,Automation ,Manufacturing engineering - Published
- 2020
25. Double Arch Intrusion
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Cheol-Ho Paik and Hwee‐Ho Kim
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Orthodontics ,Intrusion ,business.industry ,Vertical maxillary excess ,Medicine ,Arch ,business - Published
- 2020
26. Bandwidth-Efficient Transmission Method for User View-Oriented Video Services
- Author
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Minjae Seo and Jong-Ho Paik
- Subjects
Biomaterials ,Mechanics of Materials ,Modeling and Simulation ,Electrical and Electronic Engineering ,Computer Science Applications - Published
- 2020
27. Functional Near-Infrared Spectroscopy as a Personalized Digital Healthcare Tool for Brain Monitoring
- Author
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Zephaniah Phillips V, Raymart Jay Canoy, Seung-ho Paik, Seung Hyun Lee, and Beop-Min Kim
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Neurology ,Neurology (clinical) - Published
- 2023
28. Clinicopathologic and Prognostic Significance of Bruton's Tyrosine Kinase Expression in Diffuse Large B-Cell Lymphoma
- Author
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Jong Seok Lee, Jeong Ok Lee, Hyun Jung Kwon, Jeong Mi Yang, Jin Ho Paik, and Yeon Bi Han
- Subjects
Adult ,Male ,Cancer Research ,Vincristine ,Cyclophosphamide ,Adolescent ,Proto-Oncogene Mas ,Risk Assessment ,Translocation, Genetic ,Proto-Oncogene Proteins c-myc ,Young Adult ,International Prognostic Index ,immune system diseases ,Predictive Value of Tests ,Risk Factors ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Agammaglobulinaemia Tyrosine Kinase ,Biomarkers, Tumor ,Bruton's tyrosine kinase ,Humans ,Protein Kinase Inhibitors ,In Situ Hybridization, Fluorescence ,Aged ,Retrospective Studies ,Aged, 80 and over ,biology ,business.industry ,Gene Amplification ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Progression-Free Survival ,Lymphoma ,Oncology ,Proto-Oncogene Proteins c-bcl-2 ,Drug Resistance, Neoplasm ,Cancer research ,biology.protein ,Rituximab ,Female ,Lymphoma, Large B-Cell, Diffuse ,business ,Diffuse large B-cell lymphoma ,Tyrosine kinase ,medicine.drug - Abstract
BACKGROUND/AIM Bruton's tyrosine kinase (BTK)-mediated B-cell-receptor signaling drives lymphomagenesis of diffuse large B-cell lymphoma (DLBCL). We investigated the clinicopathological significance of BTK positivity in DLBCL according to known molecules related to resistance to BTK inhibitors [BCL2 apoptosis regulator (BCL2)/MYC proto-oncogene, bHLH transcription factor (MYC)]. PATIENTS AND METHODS We evaluated BTK expression immunohistochemically in 106 DLBCLs considering their BCL2/MYC status. RESULTS Considering the whole cohort, BTK was expressed in 65.1%, including 70.4% (50/71) of non-germinal center B-cell-like (non-GCB) subtype; BCL2 expression was detected in 60.4%, MYC expression in 15.1%, MYC translocation in 4.2% (4/96) and MYC gain/amplification in 7.6% (8/105). Overall and in the non-GCB cohort, BTK positively correlated with high international prognostic index (both p=0.005) and stage (p=0.006 and p=0.002), and with BCL2 intensity (p=0.005 and p=0.026, respectively); MYC gain/amplification total cohort (p=0.038). Moreover, high risk, defined as co-expression of BTK and either or both BCL2/MYC, independently predicted shorter progression-free survival in patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) (all R-CHOP-treated patients: hazard ratio=2.565, p=0.044; R-CHOP-treated non-GCB subgroup: HR=3.833, p=0.019). CONCLUSION BTK expression may be utilized to stratify risk in patients with DLBCL.
- Published
- 2021
29. Plasma cell myeloma with pure lymphocyte-like morphology
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Hee Ryeong Jang, Sook Won Ryu, Jin Ho Paik, and Kyoungyul Lee
- Subjects
medicine.medical_specialty ,Pathology ,Morphology (linguistics) ,Hematology ,medicine.anatomical_structure ,business.industry ,Lymphocyte ,Internal medicine ,Plasma Cell Myeloma ,Medicine ,General Medicine ,business - Published
- 2020
30. Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
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Jooryung Huh, Min Sun Cho, Bong Kyung Shin, Jong Sil Lee, Se Hoon Kim, In Ho Choi, Young Hyeh Ko, Bo Mi Kim, Suk Jin Choi, Yo Sep Chong, Hye Ra Jung, Ji Young Choe, Soo Kee Min, Hojung Lee, Seol Bong Yoo, Hee Kyung Chang, Wook Youn Kim, Woo Ick Yang, Hee Jung Cha, Yoon Kyung Jeon, Dae Woon Eom, Min Gyoung Park, Ji-Eun Kim, Geongsin Park, Jiyeon Han, Hyun-Jung Kim, Yoo Duk Choi, Kyu Yun Jang, Seung Sook Lee, H.K. Kim, Hyekyung Lee, Jo Heon Kim, Jin Ho Paik, Hyang Im Lee, Young A. Kim, and Sun Och Yoon
- Subjects
medicine.medical_specialty ,Histology ,Hematology ,business.industry ,T cell ,Follicular lymphoma ,Lymphoproliferative disorders ,medicine.disease ,Gastroenterology ,Pathology and Forensic Medicine ,Lymphoma ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Nodular sclerosis ,immune system diseases ,hemic and lymphatic diseases ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,business ,B-cell lymphoma ,B cell ,030215 immunology - Abstract
To determine the relative frequency and change of malignant lymphoma in Korea according to the 4th World Health Organization (WHO) classification and compare with previous reports. Between 2015 and 2016, 7737 new patients with malignant lymphoma were enrolled from 31 institutes, with their clinicopathologic information obtained, and evaluated for the relative frequency of lymphoma subtypes. The relative frequency of non-Hodgkin lymphoma (NHL) was 94.8%, and that of Hodgkin lymphoma (HL) was 5.2%. B cell lymphomas accounted for 83.1% of all NHLs; T/natural killer (NK) cell lymphomas, 16.4%; and immunodeficiency-associated lymphoproliferative disorders, 0.5%. The most common NHL subtypes were diffuse large B cell (41.5%), extranodal marginal zone (MALT, 19.8%), follicular (7.5%), NK/ T cell (4.2%), and peripheral T cell lymphomas, not otherwise specific (PTCL, NOS, 3.4%). Nodular sclerosis was the predominant HL subtype (48.5%), followed by mixed cellularity (28.7%), lymphocyte-rich (6.8%), lymphocyte-depleted (1.5%), lymphocyte-predominant (2.8%), and unclassified HL (11.8%). Compared with a previous report, increased B cell lymphomas (77.6–83.1%) and slightly decreased NK/T cell lymphomas and PTCL were observed. The incidence of follicular lymphoma increased by more than 2.5-fold (2.9–7.5%). Incidence rates of newly diagnosed lymphomas were lower for HL and higher for extranodal NHL, MALT, and nasal type NK/T cell lymphomas in Korea than those in Western countries. A slight increase in the relative frequency of B cell lymphoma and a prominent increase in follicular lymphoma may be attributed to refined diagnostic criteria and Westernized disease patterns.
- Published
- 2019
31. Joint Estimation of Symbol Timing and Sampling Frequency Offset for CDD-OFDM-Based DRM Systems
- Author
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Young-Hwan You, Yong-An Jung, and Jong-Ho Paik
- Subjects
Symbol timing offset ,Frequency selectivity ,Channel transfer function ,Mean squared error ,Orthogonal frequency-division multiplexing ,Computer science ,020206 networking & telecommunications ,02 engineering and technology ,Digital Radio Mondiale ,Sampling frequency offset ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,Cyclic delay diversity ,Electrical and Electronic Engineering ,Algorithm - Abstract
In this paper, an efficient symbol timing offset (STO) and sampling frequency offset (SFO) estimation scheme is proposed in an orthogonal frequency division multiplexing-based digital radio mondiale system using cyclic delay diversity. By using a periodic nature of channel transfer function, cyclic delay and pilot pattern with a maximum channel power are chosen, which aids to enable a robust estimation of STO and SFO against frequency selectivity of the channel. As a performance measure, the mean squared error of the proposed scheme is theoretically derived and is verified through simulations. By simulation results, the proposed estimation scheme is proved to profit from properly selected cyclic delay and pilot pattern, with a superior performance over the conventional estimation scheme.
- Published
- 2019
32. A Semiotic Study on the Background Color of Fantasy Game
- Author
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Cholong Lim and Chul-Ho Paik
- Subjects
Background color ,Aesthetics ,media_common.quotation_subject ,Semiotics ,Fantasy ,Art ,media_common - Published
- 2018
33. Genetic profiles of subcutaneous panniculitis-like T-cell lymphoma and clinicopathological impact of HAVCR2 mutations
- Author
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Jooryung Huh, Hee Jeong Cha, Kwangsoo Kim, Jiwon Koh, Jin Ho Paik, Seungchan Mun, Cheol Lee, Yoon Kyung Jeon, Insoon Jang, Jin Man Kim, Junhun Cho, Young Hyeh Ko, Jiyeon Han, Chan-Sik Park, Young Ha Oh, and Heounjeong Go
- Subjects
Mutation ,Hemophagocytic lymphohistiocytosis ,Panniculitis ,business.industry ,CCR4 ,Membrane Proteins ,Hematology ,Genetic Profile ,medicine.disease ,medicine.disease_cause ,Lymphoma, T-Cell ,Lymphoma ,Germline mutation ,Subcutaneous Panniculitis-Like T-Cell Lymphoma ,Cancer research ,Medicine ,Humans ,UNC13D ,Epigenetics ,business ,Hepatitis A Virus Cellular Receptor 2 - Abstract
Recent studies identified germline mutations in HAVCR2 (encoding T-cell immunoglobulin mucin 3) as a genetic factor that predisposes to subcutaneous panniculitis-like T-cell lymphoma (SPTCL). However, the differences between HAVCR2-mutated (HAVCR2MUT) and HAVCR2 wild-type (HAVCR2WT) SPTCLs remain unclear. A nationwide cohort of 53 patients with SPTCL diagnosed at 8 Korean institutions was established. Whole-exome sequencing and RNA-sequencing were performed on 8 patients in the discovery set. In the validation set, targeted gene sequencing or direct sequencing of HAVCR2 was performed. Of 49 patients with available HAVCR2 status, 25 (51.0%) were HAVCR2Y82C. HAVCR2Y82C was associated with younger age (P = .001), development of hemophagocytic lymphohistiocytosis or hemophagocytic lymphohistiocytosis–like systemic illness (P < .001), and short relapse-free survival (RFS) (P = .023). Most mutated genes in SPTCLs were involved in immune responses, epigenetic modifications, and cell signaling. Mutations in UNC13D, PIAS3, and KMT2D were more frequent in HAVCR2WT SPTCLs. At the gene expression level, HAVCR2Y82C SPTCLs were enriched in genes involved in IL6-JAK-STAT3 signaling and in tumor necrosis factor-α signaling via NF-κB. CCR4 was significantly upregulated in HAVCR2WT SPTCLs both at the messenger RNA level and at the protein level. We established a risk stratification system for SPTCL by integrating clinical and histopathological features, including age and HAVCR2 mutation status. This risk stratification system was strongly associated with RFS (P = .031). In conclusion, the HAVCR2Y82C mutation was common in Korean patients with SPTCL and was associated with unique clinicopathological and genetic features. Combining clinicopathological parameters could aid in predicting prognosis for patients with SPTCL.
- Published
- 2021
34. Spirally Wrapped Carbon Nanotube Microelectrodes for Fiber Optoelectronic Devices beyond Geometrical Limitations toward Smart Wearable E-Textile Applications
- Author
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Hyemi Han, Hyunjung Yi, Jung Ah Lim, Hyoungjun Kim, Min-Chul Park, Seung-Ho Paik, Jongtae Ahn, Tae-Hyung Kang, Soo Jin Kim, Do Kyung Hwang, and Seongjin Park
- Subjects
Materials science ,business.product_category ,business.industry ,Transistor ,General Engineering ,General Physics and Astronomy ,02 engineering and technology ,Carbon nanotube ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Photodiode ,law.invention ,Organic semiconductor ,Microelectrode ,law ,Electrode ,Microfiber ,Optoelectronics ,General Materials Science ,Fiber ,0210 nano-technology ,business - Abstract
Fiber optoelectronics technology has recently attracted attention as enabling various form factors of wearable electronics, and the issue of how to control and optimize the configuration and physical properties of the electrode micropatterns in the microfiber devices has become important. Here, spirally wrapped carbon nanotube (CNT) microelectrodes with a controlled dimension are demonstrated for high-performance fiber optoelectronic devices. Inkjet-printed CNT microelectrodes with the desired dimension on an agarose hydrogel template are rolling-transferred onto a microfiber surface with an efficient electrical interface. A fiber organic field-effect transistor with spirally wrapped CNT microelectrodes verifies the feasibility of this strategy, where the transferred microelectrodes intimately contact the organic semiconductor active layer and the output current characteristics are simply controlled, resulting in characteristics that exceed the previous structural limitations. Furthermore, a fiber organic photodiode with spirally wrapped CNT microelectrodes, when used as a transparent electrode, exhibits a high Ilight/Idark ratio and good durability of bending. This fiber photodiode can be successfully incorporated into a textile photoplethysmography bandage for the real-time monitoring of human vital signals. This work offers a promising and efficient strategy to overcome the geometric factors limiting the performance of fiber-optic optoelectronic devices.
- Published
- 2020
35. Multichannel near-infrared spectroscopy brain imaging system for small animals in mobile conditions
- Author
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Shin-Young Kang, Youngwoon Choi, Ju-Hee Kim, Seung-Hyun Lee, Seung-Ho Paik, Beop Min Kim, and Zephaniah Phillips
- Subjects
Paper ,Computer science ,near-infrared spectroscopy ,Neuroscience (miscellaneous) ,freely moving ,Environment controlled ,Stimulation ,01 natural sciences ,010309 optics ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,0103 physical sciences ,medicine ,Radiology, Nuclear Medicine and imaging ,Brain function ,neuroimaging ,Radiological and Ultrasound Technology ,small animals ,Near-infrared spectroscopy ,stimulation kit ,equipment and supplies ,Research Papers ,Functional Brain Imaging ,Visual cortex ,medicine.anatomical_structure ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
Significance: We propose a customized animal-specific head cap and an near-infrared spectroscopy (NIRS) system to obtain NIRS signals in mobile small animals. NIRS studies in mobile small animals provide a feasible solution for comprehensive brain function studies. Aim: We aim to develop and validate a multichannel NIRS system capable of performing functional brain imaging along with a closed-box stimulation kit for small animals in mobile conditions. Approach: The customized NIRS system uses light-weight long optical fibers, along with a customized light-weight head cap to securely attach the optical fibers to the mouse. A customized stimulation box was designed to perform various stimuli in a controlled environment. The system performance was tested in a visual stimulation task on eight anesthetized mice and eight freely moving mice. Results: Following the visual stimulation task, we observed a significant stimulation-related oxyhemoglobin (HbO) increase in the visual cortex of freely moving mice during the task. In contrast, HbO concentration did not change significantly in the visual cortex of anesthetized mice. Conclusions: We demonstrate the feasibility of a wearable, multichannel NIRS system for small animals in a less confined experimental design.
- Published
- 2020
36. Immunophenotypic Landscape and Prognosis of Diffuse Large B-Cell Lymphoma with MYC/BCL2 Double Expression: An Analysis of A Prospectively Immunoprofiled Cohort
- Author
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Dae Seog Heo, Tae Min Kim, Sehui Kim, Jiwon Koh, Jin Ho Paik, Yoon Kyung Jeon, Cheol Lee, Jeemin Yim, and Bogyeong Han
- Subjects
Cancer Research ,medicine.medical_specialty ,Poor prognosis ,BCL2 ,diffuse large B-cell lymphoma ,MYC ,Gastroenterology ,lcsh:RC254-282 ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,International Prognostic Index ,immune system diseases ,Internal medicine ,Lactate dehydrogenase ,hemic and lymphatic diseases ,Medicine ,Poor performance status ,neoplasms ,high-grade B-cell lymphoma ,business.industry ,lactate dehydrogenase ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Lymphoma ,medicine.anatomical_structure ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Cohort ,double expression ,Bone marrow ,prognosis ,business ,Diffuse large B-cell lymphoma ,030215 immunology - Abstract
Diffuse large B-cell lymphoma (DLBCL) patients with MYC/BCL2 double expression (DE) show poor prognosis and their clinical outcomes after R-CHOP therapy vary immensely. We investigated the prognostic value of DE in aggressive B-cell lymphoma patients (n = 461), including those with DLBCL (n = 417) and high-grade B-cell lymphoma (HGBL, n = 44), in a prospectively immunoprofiled cohort. DE was observed in 27.8% of DLBCLs and 43.2% of HGBLs (P = 0.058). DE-DLBCL patients were older (P = 0.040) and more frequently exhibited elevated serum LDH levels (P = 0.002), higher international prognostic index (IPI, P = 0.042), non-germinal-center B-cell phenotype (P <, 0.001), and poor response to therapy (P = 0.042) compared to non-DE-DLBCL patients. In R-CHOP-treated DLBCL patients, DE status predicted poor PFS and OS independently of IPI (P <, 0.001 for both). Additionally, in DE-DLBCL patients, older age (>, 60 years, P = 0.017), involvement of ³, 2 extranodal sites (P = 0.021), bone marrow involvement (P = 0.001), high IPI (P = 0.017), CD10 expression (P = 0.006), poor performance status (P = 0.028), and elevated LDH levels (P <, 0.001) were significantly associated with poor OS. Notably, DE-DLBCL patients with normal LDH levels exhibited similar PFS and OS to those of patients with non-DE-DLBCL. Our findings suggest that MYC/BCL2 DE predicts poor prognosis in DLBCL. Risk stratification of DE-DLBCL patients based on LDH levels may guide clinical decision-making for DE-DLBCL patients.
- Published
- 2020
37. Regional analysis of cerebral hemodynamic changes during the head-up tilt test in Parkinson’s disease patients with orthostatic intolerance
- Author
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Shin Young Kang, Jung Bin Kim, Seung Ho Paik, Zephaniah Phillips, Byung Jo Kim, Nam Joon Jeon, and Beop Min Kim
- Subjects
Paper ,medicine.medical_specialty ,Parkinson's disease ,autonomic dysfunction ,Neuroscience (miscellaneous) ,Orthostatic intolerance ,Hemodynamics ,01 natural sciences ,010309 optics ,orthostatic hypotension ,03 medical and health sciences ,Tilt table test ,Orthostatic vital signs ,0302 clinical medicine ,head-up tilt ,Internal medicine ,0103 physical sciences ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Head up tilt ,Oxygenation ,medicine.disease ,Research Papers ,Superior frontal gyrus ,automated anatomical labeling ,Cardiology ,Parkinson’s disease ,diffuse optical tomography ,business ,030217 neurology & neurosurgery - Abstract
Significance: Cerebral oxygenation changes in the superior, middle, and medial gyri were used to elucidate spatial impairments of autonomic hemodynamic recovery during the head-up tilt table test (HUTT) in Parkinson’s disease (PD) patients with orthostatic intolerance (OI) symptoms. Aim: To analyze dynamic oxygenation changes during the HUTT and classify PD patients with OI symptoms using clinical and oxygenation features. Approach: Thirty-nine PD patients with OI symptoms [10: orthostatic hypotension (PD-OH); 29: normal HUTT results (PD-NOR)] and seven healthy controls (HCs) were recruited. Prefrontal oxyhemoglobin (HbO) changes during the HUTT were reconstructed with diffuse optical tomography and segmented using the automated anatomical labeling system. Decision trees were used for classification. Results: HCs and PD-NOR patients with positive rates of HbO change (PD-POS) showed the greatest HbO recovery in the superior frontal gyrus (SFG) during tilt. PD-OH and PD-NOR patients with negative rates of HbO change (PD-NEG) showed asymmetric reoxygenation. The classification accuracy was 89.4% for PD-POS versus PD-NEG, 71% for PD-NOR versus PD-OH, and 55.8% for PD-POS versus PD-NEG versus PD-OH. The oxygenation features were more discriminative than the clinical features. Conclusions: PD-OH showed decreased right SFG function, which may be associated with impaired compensatory autonomic responses to orthostatic stress.
- Published
- 2020
38. Hemodynamic Activity and Connectivity of the Prefrontal Cortex by Using Functional Near-Infrared Spectroscopy during Color-Word Interference Test in Korean and English Language
- Author
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Young-Jin Jung, Gihyoun Lee, Jun Yong Hong, Mezie Laurence B. Ortiz, Seung Ho Paik, Seung-Hyun Lee, Ji-Su Park, and Beop Min Kim
- Subjects
medicine.medical_specialty ,Haemodynamic response ,Hemodynamics ,English language ,hemodynamic connectivity ,Audiology ,Article ,050105 experimental psychology ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,Cortex (anatomy) ,Color word ,medicine ,functional near-infrared spectroscopy ,0501 psychology and cognitive sciences ,Prefrontal cortex ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,brain network ,General Neuroscience ,05 social sciences ,Attentional control ,color-word interference ,medicine.anatomical_structure ,Functional near-infrared spectroscopy ,Psychology ,hemodynamic response ,030217 neurology & neurosurgery - Abstract
In daily living, people are challenged to focus on their goal while eliminating interferences. Specifically, this study investigated the pre-frontal cortex (PFC) activity while attention control was tested using the self-made color-word interference test (CWIT) with a functional near-infrared spectroscopy device (fNIRS). Among 11 healthy Korean university students, overall the highest scores were obtained in the congruent Korean condition 1 (CKC-1) and had the least vascular response (VR) as opposed to the incongruent Korean condition 2 (IKC-2). The individual&rsquo, s automatic reading response caused less brain activation while IKC-2 involves color suppression. Across the three trials per each condition, no significant differences (SD) in scores and in VR since there was no intervention did. Meanwhile, SD was observed between CKC-1 and English Congruent Condition 3 (ECC-3) across trials. However, SD was only observed on the third trial of VR. In the connectivity analysis, right and left PFC are activated on ECC-3. In CKC-1 and IKC-2, encompassing dorsomedial and dorsolateral although CKC-1 has less connection and connectivity due to less brain activation as compared. Therefore, aside from VR, brain connectivity could be identified non-invasively using fNIRS without ionizing radiation and at low-cost.
- Published
- 2020
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39. Discovery of Novel Recurrent Mutations and Clinically Meaningful Subgroups in Nodal Marginal Zone Lymphoma
- Author
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Yoon Kyung Jeon, Hyun Kyung Ahn, Kwangsoo Kim, Jiwon Koh, Megan S. Lim, Insoon Jang, Cheol Lee, Seongmin Choi, Chul Woo Kim, Jin Ho Paik, Sehui Kim, and Ingeon Jang
- Subjects
0301 basic medicine ,Cancer Research ,Cell ,Biology ,lcsh:RC254-282 ,Article ,whole exome sequencing ,Transcriptome ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,medicine ,Neoplasm ,genetics ,Exome sequencing ,RNA sequencing ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Marginal zone ,medicine.disease ,NFKBIE ,marginal zone lymphoma ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,malignant lymphoma - Abstract
Nodal marginal zone lymphoma (NMZL) is a rare B-cell neoplasm, the genetic and transcriptomic landscape of which are unclear. Using high-throughput sequencing for whole-exome and transcriptome, we investigated the genetic characteristics of NMZL in a discovery cohort (n = 8) and validated their features in an extended cohort (n = 30). Novel mutations in NFKBIE and ITPR2 were found in 7.9% (3/38) and 13.9% (5/36), respectively, suggesting roles for the NF-&kappa, B pathway and B-cell-receptor-mediated calcium signaling pathway in the pathogenesis of NMZL. RNA-seq showed that NMZLs were characterized by an aberrant marginal zone differentiation, associated with an altered IRF4-NOTCH2 axis and the enrichment of various oncogenic pathways. Based on gene expression profile, two subgroups were identified. Compared with subgroup 1, subgroup 2 showed the following: the significant enrichment of cell cycle-associated and MYC-signaling pathways, a more diverse repertoire of upstream regulators, and higher Ki-67 proliferation indices. We designated two subgroups according to Ki-67 labeling, and subgroup 2 was significantly associated with a shorter progression-free survival (p = 0.014), a greater proportion of large cells (p = 0.009), and higher MYC expression (p = 0.026). We suggest that NMZL has unique features and, in this study, we provide information as to the heterogeneity of this enigmatic entity.
- Published
- 2020
- Full Text
- View/download PDF
40. Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma
- Author
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Hyojin Kim, Soon Hyun Ahn, Soohyeon Kwon, Woo Jin Jeong, Jin Ho Paik, Young Ho Jung, Jin Haeng Chung, and Yun Jung Bae
- Subjects
0301 basic medicine ,Human Papillomavirus Positive ,Oncology ,Human papillomavirus ,medicine.medical_specialty ,medicine.medical_treatment ,Estrogen receptor α ,lcsh:Medicine ,Oropharynx ,Estrogen receptor ,Alphapapillomavirus ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Squamous cell carcinoma ,Internal medicine ,Humans ,Medicine ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Research ,lcsh:R ,Papillomavirus Infections ,Hazard ratio ,Estrogen Receptor alpha ,HPV infection ,Biomarker ,General Medicine ,Prognosis ,medicine.disease ,Radiation therapy ,Oropharyngeal Neoplasms ,030104 developmental biology ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Biomarker (medicine) ,Immunohistochemistry ,business ,Biomarkers ,Chemoradiotherapy - Abstract
Background Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design deintensification regimens. Here, we investigated estrogen receptor α (ERα) as a prognostic biomarker with therapeutic implications in OPSCC alongside factors associated with HPV infection. Methods We performed immunohistochemistry for ERα and p53 using formalin-fixed, paraffin-embedded tissues and assessed the HPV status using p16 immunohistochemistry and HPV DNA testing in 113 consecutive patients with OPSCC treated with surgical resection or radiotherapy/chemoradiotherapy. Results ERα expression and p53 alteration was observed in 35.4% and 21.2% OPSCCs; 45.6% and 1.3% p16+/HPV+ OPSCCs; and 11.5% and 76.9% p16− OPSCCs, respectively. These data suggest that OPSCC pathogenesis varies with HPV status. Furthermore, ERα expression was associated with improved overall survival (OS) in both HPV+ (p16+/HPV+ OPSCC) and p16+ (p16+ OPSCC irrespective of HPV status) models (p = 0.005 and p = 0.006, respectively) and with improved OS adjusted for stage (p = 0.037, hazard ratio: 0.109, 95% confidence interval 0.013–0.871) in the p16+ model. Conclusions ERα is a potential predictive biomarker for improved survival in both HPV+ and p16+ OPSCC models.
- Published
- 2020
41. A Novel Singular Value Decomposition-Based Denoising Method in 4-Dimensional Computed Tomography of the Brain in Stroke Patients with Statistical Evaluation
- Author
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Seung-Hyun Lee, Gihyoun Lee, Jun Yong Hong, Beop Min Kim, Won Seok Yang, Seung Ho Paik, Ji-Su Park, Young-Jin Jung, and Jeong Youn Kim
- Subjects
Image quality ,Computer science ,acute stroke ,brain ,contrast-to-noise ,Perfusion scanning ,Computed tomography ,lcsh:Chemical technology ,Biochemistry ,Gaussian noise ,Article ,030218 nuclear medicine & medical imaging ,Analytical Chemistry ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Signal-to-noise ratio ,Singular value decomposition ,Medical imaging ,medicine ,Image Processing, Computer-Assisted ,Humans ,image quality ,lcsh:TP1-1185 ,Electrical and Electronic Engineering ,Instrumentation ,medicine.diagnostic_test ,business.industry ,singular value decomposition ,Pattern recognition ,computed tomography ,Gold standard (test) ,Atomic and Molecular Physics, and Optics ,Stroke ,radiation doses ,symbols ,Artificial intelligence ,signal-to-noise ratio ,business ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery ,4-Dimensional Computed Tomography ,Algorithms - Abstract
Computed tomography (CT) is a widely used medical imaging modality for diagnosing various diseases. Among CT techniques, 4-dimensional CT perfusion (4D-CTP) of the brain is established in most centers for diagnosing strokes and is considered the gold standard for hyperacute stroke diagnosis. However, because the detrimental effects of high radiation doses from 4D-CTP may cause serious health risks in stroke survivors, our research team aimed to introduce a novel image-processing technique. Our singular value decomposition (SVD)-based image-processing technique can improve image quality, first, by separating several image components using SVD and, second, by reconstructing signal component images to remove noise, thereby improving image quality. For the demonstration in this study, 20 4D-CTP dynamic images of suspected acute stroke patients were collected. Both the images that were and were not processed via the proposed method were compared. Each acquired image was objectively evaluated using contrast-to-noise and signal-to-noise ratios. The scores of the parameters assessed for the qualitative evaluation of image quality improved to an excellent rating (p <, 0.05). Therefore, our SVD-based image-denoising technique improved the diagnostic value of images by improving their quality. The denoising technique and statistical evaluation can be utilized in various clinical applications to provide advanced medical services.
- Published
- 2020
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42. Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration
- Author
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Hiroyoshi Takeuchi, GumJee Choi, Jung-Jin Kim, Seoyoung Kim, Hiroyuki Uchida, Yong-Sung Choi, In-Ho Paik, Yo Han Lee, Jaewon Suh, SuYoun Kim, Seung Hyun Kim, MinJung Koh, and Euitae Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Illness duration ,Injections, Intramuscular ,Internal medicine ,Paliperidone Palmitate ,medicine ,Humans ,In patient ,Paliperidone ,Prospective Studies ,Antipsychotic ,business.industry ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Long acting ,Treatment Outcome ,Schizophrenia ,Delayed-Action Preparations ,Linear Models ,Female ,business ,medicine.drug ,Antipsychotic Agents ,Follow-Up Studies - Abstract
OBJECTIVE This study aimed to examine the degree of clinical and functional improvement after paliperidone long-acting injectable (LAI) administration according to the duration of illness. METHODS Patients with schizophrenia diagnosed by ICD-10 criteria who were planned to start once-monthly paliperidone LAI were recruited from 2010 to 2017. Clinical and functional changes were measured every 4 weeks using the Clinical Global Impressions-Severity of Illness scale (CGI-S) and Personal and Social Performance scale (PSP), respectively, for 6 months after paliperidone LAI initiation. Improvements after starting paliperidone LAI were compared among patients with duration of illness < 3 years, ≥ 3 and < 10 years, and ≥ 10 years. RESULTS A total of 1,166 participants (duration of illness < 3 years, n = 240; 3 ≤ duration of illness < 10 years, n = 442; duration of illness ≥ 10 years, n = 484) were enrolled. The total olanzapine-equivalent doses of antipsychotics and the LAI monotherapy proportion at the final visit were significantly different among the 3 duration of illness groups (dose: F₂,₁₁₆₃ = 18.41, P < .001; monotherapy: χ²₂ = 11.73, P = .003). The changes in CGI-S score were significantly different according to the duration of illness, and those with duration of illness < 3 years showed the best improvement (group × week: χ²₁₂ = 25.33, P = .013). All 3 groups showed significantly improved PSP scores (week: χ²₆ = 294.2, P < .001). CONCLUSIONS Starting paliperidone LAI significantly improved clinical and functional outcomes in patients with schizophrenia, especially those with shorter duration of illness. These findings suggest that LAI antipsychotic administration may be considered in early-stage schizophrenia for improved outcomes.
- Published
- 2020
43. Monitoring cognitive effects of childhood ADHD using diffuse optical tomography (Conference Presentation)
- Author
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Youngwoon Choi, Seung-Ho Paik, Zephaniah Phillips, Beop Min Kim, Shin-Young Kang, and Bung Nyun Kim
- Subjects
Response rate (survey) ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Cognition ,Audiology ,Impulsivity ,medicine.disease ,Diffuse optical imaging ,Neurodevelopmental disorder ,Auditory stimulation ,mental disorders ,medicine ,Impulse (psychology) ,medicine.symptom ,Cerebral perfusion pressure ,business ,media_common - Abstract
Childhood Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder whose symptoms include the inability to focus, impulsivity, and extremely active behavior. Advanced Test of Attention (ATA) is used to diagnose ADHD by measuring the patient’s impulse rate, average response rate, standard deviation rate, and omission rate during visual and auditory stimulation. However, ATA metrics are often skewed due to long task times and level of difficulty. We recruited healthy and ADHD children to monitor their performance during ATA. This work highlights diffuse optical tomography’s capability in providing cerebral perfusion changes to supplement ATA results for monitoring the cognitive effects of ADHD.
- Published
- 2020
44. Outbreak Prediction of Hepatitis A in Korea based on Statistical Analysis and LSTM Network
- Author
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Mun Kyu Lee, In Seop Na, and Jong Ho Paik
- Subjects
0209 industrial biotechnology ,Computer science ,business.industry ,education ,Supervised learning ,Outbreak ,Hepatitis A ,Regression analysis ,02 engineering and technology ,medicine.disease ,Machine learning ,computer.software_genre ,020901 industrial engineering & automation ,Correlation analysis ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,020201 artificial intelligence & image processing ,Statistical analysis ,Artificial intelligence ,business ,Web crawler ,computer - Abstract
The biggest cause of the epidemic is “unpredictable.” In Korea, the number of patients with hepatitis A has been increasing recently, and the government enacted a law in 1954 to effectively manage diseases such as hepatitis A. The purpose of this paper is to design a model for predicting trends in order to minimize the damage caused by the prevalence of infectious diseases. As a tool for it, various statistical techniques and Supervised Learning of Machine Learning and LSTM techniques were used. To this end, data were collected using Web Crawling and other data, correlation analysis using Regression analysis was conducted, and prediction models were designed using Machine Learning and LSTM.
- Published
- 2020
45. Factors Affecting the Chipping Operation Based on the Screen Size of the Drum Chipper
- Author
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Sang-Kyun Han, Min-Jae Cho, Seung-Ho Paik, Yun Sung Choi, Jae-Heun Oh, Ho-Seong Mun, and Dae Hyun Kim
- Subjects
screen size ,business.industry ,020209 energy ,Biomass ,Forestry ,lcsh:QK900-989 ,02 engineering and technology ,Pulp and paper industry ,Renewable energy ,productivity and cost ,fuel consumption ,Productivity (ecology) ,lcsh:Plant ecology ,0202 electrical engineering, electronic engineering, information engineering ,Fuel efficiency ,Environmental science ,020201 artificial intelligence & image processing ,Woodchips ,Particle size ,particle size distribution ,biomass utilization ,Energy source ,business ,Water content - Abstract
Forest biomass has recently been highlighted as a renewable energy source in South Korea. As the Renewable Energy Certificate weight has been revised to encourage the use of forest biomass for energy production, forest operations have focused on the development of new technologies and harvesting methods for the extraction and utilization of forest biomass. This study examined the application of a drum chipper to forest biomass and analyzed the effects of screen size (40, 50, 65, and 80 mm) on productivity, cost, and particle size distribution. When the screen size was 40 mm to 65 mm, the chipping productivity improved by up to 3.6 times, the fuel consumption decreased by up to 29.7%, and the chipping cost was reduced by up to 31.9%. The fines content tended to decrease with an increase in screen size. The size of woodchips was less than 100 mm in length and ranged from 10 to 63 mm. The 65 mm screen was the most effective (e.g., producing optimal wood chip size at an acceptable production rate) for the chipping operation. Harvesting methods and drying time are also important factors that determine the utilization efficiency of forest biomass. Therefore, further research should be focused on the effect of moisture content on chipping productivity, power required, and fine particle size in forest biomass productions.
- Published
- 2019
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46. Character Concept Designs Utilizing Formative Methods in Fashion Design
- Author
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Mijung Choi, Yejin Kim, and Chul-ho Paik
- Published
- 2018
47. Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma
- Author
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Jin Ho Paik, Ji-Young Jang, Jeong Mi Yang, and Yoon Kyung Jeon
- Subjects
Male ,0301 basic medicine ,Microarray ,lcsh:Medicine ,Apoptosis ,Cohort Studies ,0302 clinical medicine ,International Prognostic Index ,Antineoplastic Combined Chemotherapy Protocols ,Cluster Analysis ,Aged, 80 and over ,microRNA ,General Medicine ,Middle Aged ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,Lymphoma, Large B-Cell, Diffuse ,medicine.drug ,Adult ,Vincristine ,Cell Survival ,Diffuse large B cell lymphoma ,Disease-Free Survival ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,03 medical and health sciences ,miR-197 ,Cell Line, Tumor ,medicine ,Humans ,Chemosensitivity ,Survival analysis ,Aged ,business.industry ,Gene Expression Profiling ,Research ,lcsh:R ,medicine.disease ,Lymphoma ,Gene expression profiling ,MicroRNAs ,030104 developmental biology ,Doxorubicin ,Multivariate Analysis ,Cancer research ,business ,Diffuse large B-cell lymphoma - Abstract
Background Diffuse large B cell lymphoma (DLBCL) contains heterogeneous subtypes with various molecular dysregulation at the gene, protein and microRNA levels. Compared with the GCB subtype, the non-germinal center B-like (non-GCB)/activated B cell-like (ABC) subtype exhibits frequent progression despite standard immunochemotherapy. We aimed to investigate the effects of miR-197 on the progression and chemosensitivity of DLBCL with respect to the GCB and non-GCB/ABC subtypes. Methods To screen distinctively expressed microRNAs, microRNA expression patterns were analyzed in 10 DLBCL cases by microarray chip assays. Using quantitative real-time polymerase chain reaction (qRT-PCR), associations between miR-197 expression levels and clinicopathologic variables were investigated in 51 DLBCL tissue samples. The effects of miR-197 on doxorubicin chemosensitivity were investigated using the OCI-Ly1 and SUDHL9 cell lines. Results MicroRNA expression profiling by hierarchical clustering revealed that miR-197 was one of the distinctively expressed microRNAs in DLBCL. Quantitative analysis using qRT-PCR revealed that miR-197 levels were not correlated with clinicopathologic variables, including the international prognostic index, but low miR-197 levels were significantly associated with lymphoma progression defined by refractoriness, relapse or death in the rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP)-treated subgroup (n = 43; p = 0.004). Among the three molecular groups, i.e., the GCB, non-GCB/miR-197low and non-GCB/miR-197high groups, progression was most frequently observed in the non-GCB/miR-197low group in the full cohort (p = 0.013) and the R-CHOP cohort (p = 0.008). In survival analysis, low miR-197 levels were independently predictive of shorter progression-free survival in the R-CHOP cohort (p = 0.031; HR = 27.9) and the non-GCB subgroup (p = 0.037; HR = 21.5) but not in the GCB subgroup. Using SUDHL9 (ABC type) and OCI-Ly1 (GCB type) cells, the effects of doxorubicin on reducing cell viability were enhanced by miR-197 transfection. In apoptosis assays, miR-197 transfection enhanced doxorubicin-induced apoptosis in SUDHL9 cells but not in OCI-Ly1 cells, suggesting a chemosensitizing effect of miR-197 in ABC DLBCL. Conclusions These results suggest the role of miR-197 as a biomarker with potential therapeutic implications. Electronic supplementary material The online version of this article (10.1186/s12967-018-1537-0) contains supplementary material, which is available to authorized users.
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- 2018
48. Low expression of CD40L in tumor-free lymph node of oral cavity cancer related with poor prognosis
- Author
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Woo Jin Jeong, Jin Ho Paik, Soon Hyun Ahn, Yoon Chan Rah, Eun Hui Jeon, Soon Young Kwon, Jae Cheul Ahn, and Hyojin Kim
- Subjects
Adult ,Male ,0301 basic medicine ,CD40 Ligand ,Kaplan-Meier Estimate ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Surgical oncology ,Gene expression ,Biomarkers, Tumor ,medicine ,Humans ,Lymph node ,Aged ,Neoplasm Staging ,business.industry ,Microarray analysis techniques ,Cancer ,Hematology ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Tumor progression ,030220 oncology & carcinogenesis ,B7-1 Antigen ,Carcinoma, Squamous Cell ,Cancer research ,Immunohistochemistry ,Female ,Mouth Neoplasms ,Surgery ,Lymph Nodes ,Lymph ,Neoplasm Recurrence, Local ,business - Abstract
Recently, the genetic alterations associated with tumor progression and impaired host immunity against transformed cells draw increased attention. Here, we characterized the differential gene expression patterns and protein expression in tumor-free lymph node from recurrent and non-recurrent tumors to identify independent prognostic markers for oral squamous cell carcinoma (OSCC). A cDNA microarray analysis was performed to identify the differentially expressed genes in regional tumor-free lymph nodes from OSCC patients with and without recurrence. Then, the protein expression of the selected genes was analyzed by immunohistochemistry in 60 OSCC patients to determine their association with survival. Widespread down-regulation of genes involved in antigen processing and recognition in lymph nodes was a distinctive feature. In univariate Kaplan–Meier analysis, lower expression of CD40L and CD80 in tumor-free lymph nodes was significantly correlated with poorer survival. In multivariate Cox regression analysis, CD40L was identified as an independent prognostic marker of disease-free survival. Our data indicate that impaired host immunity (decreased CD40L expression) along with the TNM staging might be an important factor determining the prognosis of OSCC.
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- 2018
49. High expression of MMP-9 is associated with better prognosis in extrahepatic bile duct cancer patients
- Author
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Jin-Young Jang, Sun Whe Kim, Kyubo Kim, Eui Kyu Chie, Do Youn Oh, Jin Ho Paik, and Younghee Park
- Subjects
Adult ,Male ,Antimetabolites, Antineoplastic ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Adenocarcinoma ,Gastroenterology ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Bile Ducts, Extrahepatic ,Internal medicine ,Humans ,Medicine ,Stage (cooking) ,Aged ,Neoplasm Staging ,Chemotherapy ,business.industry ,Bile duct ,Cancer ,Chemoradiotherapy, Adjuvant ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,Survival Rate ,Radiation therapy ,Biliary Tract Surgical Procedures ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Matrix Metalloproteinase 9 ,Oncology ,030220 oncology & carcinogenesis ,Concomitant ,Multivariate Analysis ,Female ,Radiotherapy, Adjuvant ,030211 gastroenterology & hepatology ,Surgery ,Fluorouracil ,Lymph Nodes ,business - Abstract
Purpose To evaluate the prognostic value of matrix metalloproteinase-9 (MMP-9) in patients with extrahepatic bile duct (EHBD) cancer undergoing surgical resection and adjuvant radiotherapy. Methods Between January 2000 and August 2006, patients who underwent complete resection followed by adjuvant radiotherapy for EHBD cancer were enrolled in this study. The expression of MMP-9 was assessed with immunohistochemical staining. The prognostic values of the MMP-9 expression and other clinicopathologic factors were evaluated in univariate and multivariate analyses. Results Sixty-six patients were included in this study. All received radiotherapy with a median dose of 40 Gy (range, 40–56), and 61 patients received concomitant fluoropyrimidine chemotherapy. MMP-9 was highly expressed in 33 patients (50.0%). MMP-9 expression was significantly associated with locoregional recurrence-free survival (LRRFS) and overall survival (OS) but not with distant metastasis-free survival (DMFS). The 5-year LRRFS and OS rates were 50.8% versus 86.5% (p = .0281), and 23.3% versus 68.1% (p = .0087) in patients with low and high expression of MMP-9, respectively. Among the clinicopathologic factors, tumor location was associated with DMFS and OS (p = .0292 and .0003, respectively). Nodal stage and histologic differentiation showed significant association with DMFS (p = .0277 and .0060, respectively). Based on multivariate analysis for OS, tumor location was the only significant prognostic factor (p = .0021), while MMP-9 expression showed marginal significance (p = .0633). Conclusion MMP-9 expression is a useful prognostic factor for predicting LRRFS and OS in patients with EHBD cancer after surgical resection and adjuvant radiotherapy.
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- 2018
50. A study on self-expression attitude and fandom phenomenon of avatar customizing
- Author
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Jun-Gi Son and Chul-Ho Paik
- Published
- 2018
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