58 results on '"Ideo, G."'
Search Results
2. Applicazione della value-based medicine nella valutazione della cura dei pazienti affetti da epatite
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Fornari, C, Cortesi, PA, Conti, S, Okolicsanyi, S, Rota, M, Ciaccio, A, Gemma, M, Scalone, L, Cesana, G, Cozzolino, P, Fabris, L, Colledan, M, Fagiuoli, S, Ideo, G, Garcia-Tsao, G, Belli, LS, Munari, LM, Mantovani, LG, Strazzabosco, M, Fornari, C, Cortesi, P, Conti, S, Okolicsanyi, S, Rota, M, Ciaccio, A, Gemma, M, Scalone, L, Cesana, G, Cozzolino, P, Fabris, L, Colledan, M, Fagiuoli, S, Ideo, G, Garcia-Tsao, G, Belli, L, Munari, L, Mantovani, L, and Strazzabosco, M
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Value- based medicine, epatite B, epatite C - Published
- 2018
3. The rational use of albumin in patients with cirrhosis and ascites. A Delphi study for the attainment of a consensus on prescribing standards
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GENTILINI P, BERNARDI M, BOLONDI L, CRAXI, Antonio, GASBARRINI G, IDEO G, LAFFI, G, LA VILLA G, SALERNO F, VENTURA E, PULAZZINI A, SEGANTINI L, ROMANELLI RG, GENTILINI P., BERNARDI M., BOLONDI L., CRAXI A., GASBARRINI G., IDEO G., LAFFI G., LA VILLA G., SALERNO F., VENTURA E., PULAZZINI A., SEGANTINI L., ROMANELLI R.G., GENTILINI P, BERNARDI M, BOLONDI L, CRAXI' A, GASBARRINI G, IDEO G, LAFFI, LA VILLA G, SALERNO F, VENTURA E, PULAZZINI A, SEGANTINI L, and ROMANELLI RG
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ascite ,DELPHI METHOD ,ALBUMIN ,ASCITES ,CIRRHOSIS ,cirrhosi - Abstract
Background. Ascites is one of the most frequent severe complications in patients with liver cirrhosis. The treatment of this chronic disease usually requires the prolonged use of albumin, frequently continued even after patients' discharge from the hospital. Aims. Aim of the study was to define a consensus among Italian physicians with regard to the use of albumin in patients with decompensated cirrhosis and ascites. Methods. The study adopted the Delphi technique to conduct the consensus activities. All controversial issues related to the use of albumin were identified by the experts' board and proposed to the 68 participating hepatology centres through two subsequent questionnaires. The questionnaires, returned by the specialists involved, were collected and the answers classified to verify the elements on which a consensus was reached. Results. The home use of albumin can help to improve the patient's general conditions and well-being. About 77% of the experts involved considered likely that albumin administration could shorten hospital stays or could reduce the number of hospital admissions. The results of the study, along with a socioeconomic analysis, were presented to the Italian Drug Commission, which subsequently removed the specific hypoalbuminemia level as a prerequisite for having the drug reimbursed by the National Health Service. Conclusions. For an outpatient prescription, the hypoalbuminemia limit of 2.5 g/dl or less is not sufficient, while the decision whether to administer the drug requires the evaluation of patient's overall clinical conditions as an essential criterion for the prescription of a home treatment with albumin.
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- 2004
4. Liver transplantation for hepatocellular carcinoma: prognostic factors associated long-term survival
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Colella, G., Rondinara, G. F., Carlis, L., Sansalone, C. V., Slim, A. O., paolo aseni, Kossetti, O., Gasperi, A., Minola, E., Bottelli, R., Belli, L. S., Ideo, G., Forti, D., Colella, G, Rondinara, G, De Carlis, L, Sansalone, C, Slim, A, Aseni, P, Kossetti, O, De Gasperi, A, Minola, E, Bottelli, R, Belli, L, Ideo, G, and Forti, D
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Adult ,Male ,Transplantation ,Carcinoma, Hepatocellular ,Liver transplantation ,Hepatocellular carcinoma ,Liver Neoplasms ,Humans ,Female ,Survivors ,Middle Aged ,Prognosis - Abstract
Between December 1985 and February 1995, 260 orthotopic liver transplantations (OLTX) were performed on 238 patients at Niguarda Hospital. Sixty-three patients had hepatocellular carcinoma (HCC); in 13 of the patients HCC was incidental. All patients had negative lymph nodes. According to the Child classification, 13 patients were Child A, 30 Child B, and 18 Child C. According to the TNM classification, 11 patients were stage I, 22 stage II, 15 stage III, and 15 stage IVa. Pre-OLTX chemoembolization was performed on 25 patients. The perioperative mortality rate was 27% (17 patients). Overall survival and disease-free actuarial survival rates at 1, 3, and 5 years were 94%, 76%, 76%, and 83%, 75%, 75%, respectively. Survival curves were compared for 16 different variables. No difference was observed for all parameters analyzed except tumor site, TNM stage, pre-OLTX AFP levels and vascular infiltration. These results seem to demonstrate that the OLTX for unresectable HCC can be considered in specifically selected cases as the treatment of choice. An adequate tumor staging is also necessary for a better patient selection in order to increase survival.
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- 1996
5. Trattamento della Epatite da HCV
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Alberti A, Bonino F, Bortolotti F, Colombo M, Craxì A, Mele A, Rizzetto M, Almasio P, Androne P, Ascione A, Benvegnù L, Brunetto M, Bruno S, Cammaà C, Di Marco V, Fattovich G, Ferrari C, Ideo G, Levriero M, Pagliaro L, Pastore G, Piccinino F, Pontisso P, Puoti C, Puoti M, Raimondo G, Rumi MG, Saracco G, Santantonio T, Smedile A, Zignego L., BRILLANTI, STEFANO, MAZZELLA, GIUSEPPE, Alberti A, Bonino F, Bortolotti F, Colombo M, Craxì A, Mele A, Rizzetto M, Almasio P, Androne P, Ascione A, Benvegnù L, Brillanti S, Brunetto M, Bruno S, Cammaà C, Di Marco V, Fattovich G, Ferrari C, Ideo G, Levriero M, Mazzella G, Pagliaro L, Pastore G, Piccinino F, Pontisso P, Puoti C, Puoti M, Raimondo G, Rumi MG, Saracco G, Santantonio T, Smedile A, and Zignego L.
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TERAPIA ,HCV ,EPATITE - Published
- 2004
6. Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition
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Zoccali, Carmine, Ruggenenti, Piero, Perna, Annalisa, Leonardis, Daniela, Tripepi, Rocco, Tripepi, Giovanni, Mallamaci, Francesca, Remuzzi, Giuseppe, 'REIN Study Group' including Remuzzi, G, Tognoni, G, Ruggenenti, P, Bossini, N, Viola, Bf, Scolari, F, Maiorca, R, Cofano, F, Fellin, G, D'Amico, G, Dissegna, D, Brendolan, A, La Greca, G, Feriozzi, A, Ancarani, E, Gandini, E, D'Amato, I, Giangrande, A, Giannico, G, Vitale, O, Manno, C, Schena, Fp, Mazzi, A, Garini, G, Borghetti, A, Pisoni, R, Mosconi, L, Bertani, T, Scanferla, F, Bazzato, G, Oliva, E, Zoccali, C, Toti, G, Sisca, S, Maggiore, Q, Pignone, E, Boero, R, Piccoli, Giorgina Barbara, Piperno, R, Rosati, A, Salvadori, M, Ene Iordache, B, Remuzzi, A, Perna, A, Benini, R, Tammuzzo, L, Gaspari, F, Arnoldi, F, Ciocca, I, Signorini, O, Ferrari, S, Gritti, D, Roggeri, A, Del Priore, L, Cattaneo, D, Stucchi, N, Migone, L, Marubini, E, Del Favero, A, Ideo, G, Geraci, E, and Loi, U.
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Ramipril ,Adult ,Male ,medicine.medical_specialty ,030232 urology & nephrology ,Urology ,Angiotensin-Converting Enzyme Inhibitors ,030204 cardiovascular system & hematology ,Aged ,Disease Progression ,Female ,Humans ,Middle Aged ,Phosphates ,Randomized Controlled Trials as Topic ,Renal Insufficiency, Chronic ,Renin-Angiotensin System ,Nephrology ,Nephropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Renin–angiotensin system ,medicine ,Renal Insufficiency ,Chronic ,Risk factor ,Ace inhibition ,Creatinine ,business.industry ,Confounding ,General Medicine ,Phosphate ,medicine.disease ,3. Good health ,Endocrinology ,chemistry ,business ,medicine.drug - Abstract
Phosphate may promote the onset and progression of chronic nephropathies. Here we evaluated the relationships between baseline serum phosphate levels, disease progression, and response to ACE inhibition in 331 patients with proteinuric nephropathies in the prospective Ramipril Efficacy In Nephropathy (REIN) trial. Independent of treatment, patients with phosphate levels in the highest two quartiles progressed significantly faster either to ESRD or to a composite endpoint of doubling of serum creatinine or ESRD compared with patients with phosphate levels below the median (P < 0.001). Results were similar when we analyzed phosphate as a continuous variable (P ≤ 0.004). The renoprotective effect of ramipril decreased as serum phosphate increased (P ≤ 0.008 for interaction); this modification of the treatment effect by phosphate persisted despite adjusting for potential confounders such as GFR and urinary protein. In summary, these data suggest that phosphate is an independent risk factor for progression of renal disease among patients with proteinuric CKD, and high levels of phosphate may even attenuate the renoprotective effect of ACE inhibitors. Future trials should test whether reducing serum phosphate improves renal outcomes and optimizes the renoprotective effect of ACE inhibition.
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- 2011
7. Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition
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Remuzzi, G, Tognoni, G, Ruggenenti, P, Bossini, N, Viola, Bf, Scolari, Francesco, Maiorca, Rosario, Cofano, F, Fellin, G, D'Amico, G, Dissegna, D, Brendolan, A, La Greca, G, Feriozzi, A, Ancarani, E, Gandini, E, D'Amato, I, Giangrande, A, Giannico, G, Vitale, O, Manno, C, Schena, Fp, Mazzi, A, Garini, G, Borghetti, A, Pisoni, R, Mosconi, L, Bertani, T, Scanferla, F, Bazzato, G, Oliva, E, Zoccali, C, Toti, G, Sisca, S, Maggiore, Q, Pignone, E, Boero, R, Piccoli, G, Piperno, R, Rosati, A, Salvadori, M, Ene Iordache, B, Remuzzi, A, Perna, A, Benini, R, Tammuzzo, L, Gaspari, F, Arnoldi, F, Ciocca, I, Signorini, O, Ferrari, S, Gritti, D, Roggeri, A, Del Priore, L, Cattaneo, D, Stucchi, N, Migone, L, Marubini, E, Del Favero, A, Ideo, G, Geraci, E, and Loi, U.
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ace inhibitors - Published
- 2011
8. Liver transplantation [II trapianto di fegato]
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Belli, L. S., De Carlis, L., Alberti, A., Bellati, G., Rondinara, G. F., Forti, D., Ideo, G., Belli, L, De Carlis, L, Alberti, A, Bellati, G, Rondinara, G, Forti, D, and Ideo, G
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Liver donor ,Post-transplant hepatiti ,Liver transplantation ,HBV recurrence ,Medicine (all) ,Graft dysfunction ,Hepatitis recurrence - Abstract
The level of success that we confidently expect in liver transplantation today directly results from several factors including surgical technique, the scientific use of immunosuppressive drugs and most importantly patient selection. The goal of an accurate selection is to recognize those patients that will benefit the most from the surgical procedure. This approach is crucial if we consider the limited availability of suitable donors. In general terms a patient with chronic liver disease and a Child Pugh score between 9 and 10 is considered suitable for grafting. Recent studies have shown that liver transplantation can be cost effective and lead to complete social and working rehabilitation provided that the 'timing' for the procedure is not inappropriately delayed. Medium term survival rates after liver transplantation (at 5 years) range between 60 and 80%. Disease recurrence greatly affects the morbidity and mortality after grafting. In patients transplanted for hepatitis B, active vital replication at the time of operation represents the strongest predictor of recurrence although the recent availability of antiviral nucleosids has provided effective prophylactic and therapeutic options. Recurrence of HCV infection is almost universal after transplantation but only 50% of the patients develop histologic hepatitis. The combination therapy with interferon and ribavirin has proved beneficial in modifying the natural history of recurrent disease. If untreated, recurrent hepatitis C can progress to cirrhosis in up to 15% of the patients. Lastly, the strict selection of patients undergoing liver transplantation on account of hepatocellular carcinoma has been associated with favourable results not different from those obtained with other indications
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- 1997
9. Liver transplantation in Italy: preliminary 10-year report
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Stefano Fagiuoli, Leandro, G., Bellati, G., Gasbarrini, A., Rapaccini, G. L., Pompili, M., Rendina, M., Notariis, S., Franca Villa, A., Gasbarrini, G., Ideo, G., Naccarato, R., Fagiuoli, S, Leandro, G, Bellati, G, Gasbarrini, A, Rapaccini, G, Pompili, M, Rendina, M, De Notariis, S, Francavilla, A, Gasbarrini, G, Ideo, G, and Naccarato, R
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Liver transplantation ,Liver disease ,Rejection - Abstract
Experience in liver transplantation (OLT) in Italy over a ten-year period is reported. Data were obtained using a multiple-items form collected from Italian liver transplant centres (reference centres) and other Italian institutions actively involved both in the processes of evaluation of the candidates and the follow-up of liver transplant recipients (afference centres). During this period, a total of 1046 liver transplants were performed on 954 patients, with a cumulative proportional survival of 71%. The most common indication for liver transplantation was post-hepatitic cirrhosis due to either hepatitis B virus (+/-hepatitis Delta virus) or hepatitis C virus infection. Good survival rates were observed, particularly in controversial indications, such as alcoholic cirrhosis, post-hepatitic hepatitis B virus-related cirrhosis and hepatocellular carcinoma, most likely due to proper and careful selection of the patients. Cirrhosis, secondary to an autoimmunity-based liver disease, showed the highest rate of rejection episodes. Infections, in our study population, were the most common cause of death after transplantation
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- 1996
10. Mean levels and distributions of some cardiovascular risk factors in Italy in the 1970's and the 1980's. The Italian RIFLE Pooling Project. Risk Factors and Life Expectancy
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MENOTTI A, SECCARECCIA F, LANTI M, THE RIFLE PROJECT RESEARCH GROUP, FARCHI G, CONTI S, DIMA F, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, MUSSI A, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, GIAMPAOLI S, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Seccareccia, F, Lanti, M, THE RIFLE PROJECT RESEARCH, Group, Farchi, G, Conti, S, Dima, F, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Mussi, A, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Giampaoli, S, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .
- Published
- 1995
11. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole
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Pace, F., Annese, V., Prada, A., Zambelli, A., Casalini, S., Nardini, P., Bianchi Porro, G., Rossi, Z., Fenderico, P., Molinari, F., Molinari, A., Poletti, M., Benedetti, A., Bolognini, L., Cercamondi, P., Piergallini, S., Pieroni, N., Ridolfi, F., Palazzi, A., Agnolucci, A., Ceccatelli, P., Laurenzi, F., Grassini, M., Iaquinto, G., D'Onofrio, V., Giardullo, N., Pasquale, L., Sedici, A., Moschetta, R., Maurogiovanni, G., Costan, F., Germana, B., Lecis, P., Negrini, F., Signorelli, S., Landi, P., Malaguti, P., Roda, E., De, E., Gandolfi, L., Torresan, F., Chilovi, F., Benvenuti, S., Grasso, T., Adamo, S., Azzurro, M., Carrara, M., Rubbiani, C., P. V., Di, Di, M., Belvedere, F., Di, A., Giglio, A., De Medici, A., Rodino, S., Sacca, N., Neri, M., Carbone, F., Laterza, F., Trimboli, V., Accattatis, G. C., Rizzuti, L. F., Sabatino, A., Lupinacci, G., Faleo, D., De Francesco, V., Lombardi, L. P, Minenna, M., Nocchiero, M. C., Tonti, P., Bocchini, R., D'Imperio, N., Giaccari, S., Tronci, S., Dall'Acqua, S., Berrini, E., Garatti, S., Putignano, R., Sferrazzo, A., Giacosa, A., Blanchi, S., Munizzi, F., Morlando, L., Bruno, G., Guardascione, F., Benedetti, E., Orzes, N., Pincione, F., Dell'Amico, I., Vannucci, P., Maurano, A., Calabrese, A., Napoli, G., Quagliariello, G., Sabarese, G., Pracanica, G., Gullotti, G., Princiotta, A., Rando, L., Anderloni, A., Pallotta, S., Fesce, E., Abbiati, D., Crippa, C., Ideo, G. M., Mannucci, P. M., Abbiati, C., De Franchis, R., Fazzini, L., Rossi, A., Bini, M., Chahin, N. J., Testoni, P. A., Fossati, D., Frego, R., Passaretti, S., Catanzano, C., Siciliano, S., Sivero, L., Cattaneo, D., Di Martino, V., Inzirillo, A., Lavelli, M., Del Genio, A., Maffettone, V., Napolitano, V., Del Piano, M., Ballare, M., Garello, E., Orsello, M., Capezzuto, E., Amuso, M., Marino, M., Reina, G., Craxi, A., Arini, A., Di Pisa, M., Peralta, S., Ficano, L., Miceli, D., Tarantello, M., Orlando, A., Perego, M., Alvisi, C., Pozzi, L., Torello Viera, F., Marchi, S., Arpe, P., Bellini, M., Costa, F., Da Massa Carrara, P., Manghetti, M., Meletis, P., Romano, A., Torelli, E., Garcea, M. R., Lombardi, M., Tristaino, B., Farroni, F., Di Cicco, M., Proietti, M., Tanzilli, A., Benedetti, G., Guido, E., Lacchin, T., Sablich, R., Vitalba, A., Casetti, T., Cantoni, F., Salzetta, A., Polimeni, F., Bortoli, A., Buono, M., Gozzini, C., Barberani, F., Boschetto, S., Giovannone, M., Casale, V., Assisi, D., Grassi, A., Lapenta, R., Stigliano, V., Fedeli, G., Pirozzi, G. A., Pippa, G., Bazuro, M. E., Romano, M., Borgheresi, P., Andriulli, A., Fiorella, S., De Rocco, R., Greco, G., Meloni, M., Fina, G., Frosini, G., Macchiarelli, R., Virgilio, C., Borina, E., Lauria, M., Cappelletti, F., Puglisi, F., Ravizza, M., Emanuelli, G., Battaglia, E., Dughera, L., Navino, M., Ferrari, A., Martinoglio, P., Turco, D., Pera, A., Daperno, M., Lombardo, L., Gusmaroli, R., Milesi, F., Zilli, M., Brosolo, P., De, G., Zoratti, L., Curzio, M., Amato, A., Bisso, G., Feliziani, M., Gianfrate, L., Natale, C., Petillo, A., Spadaccini, A., Meddi, P., Sciampa, G., and Ubalducci, G. M.
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Adult ,Male ,Gastrointestinal ,Time Factors ,Severity of Illness Index ,2-Pyridinylmethylsulfinylbenzimidazoles ,Endoscopy, Gastrointestinal ,Helicobacter Infections ,Dose-Response Relationship ,Gastro-oesophageal reflux disease ,Double-Blind Method ,Heartburn ,Esophagitis ,Humans ,Esophagitis, Peptic ,Curative/maintenance therapy ,Peptic ,Hepatology ,Dose-Response Relationship, Drug ,Helicobacter pylori ,Rabeprazole ,Antacids ,Anti-Ulcer Agents ,Benzimidazoles ,Female ,Gastroesophageal Reflux ,Middle Aged ,Omeprazole ,Patient Satisfaction ,Treatment Outcome ,Gastroenterology ,Endoscopy ,Drug - Abstract
Previous studies have shown similar effects of rabeprazole and omeprazole, when used at the same dose in the treatment of reflux oesophagitis. However, such studies have been conducted as superiority studies but interpreted as equivalence ones.To properly assess the comparative efficacy of rabeprazole and omeprazole in inducing complete endoscopic healing and symptom relief in patients with reflux oesophagitis.Patients (n=560) with Savary-Miller grade I-III reflux oesophagitis were randomised in a double-blind, double-dummy fashion to rabeprazole or omeprazole 20 mg once daily for 4-8 weeks. Then, patients endoscopically healed and symptomatically relieved were openly maintained with rabeprazole 10 mg or 2x10 mg once daily (in the event of clinical and/or endoscopic relapse) for a maximum of 48 weeks.After 4-8 weeks of treatment, healing (primary end-point) was observed in 228/233 (97.9%) patients in the rabeprazole group and in 231/237 (97.5%) in the omeprazole one (equivalence effect demonstrated by p0.0001 at Blackwelder test and an upper confidence limit at 97.5% of 0.023). However, rabeprazole was faster in inducing heartburn relief than omeprazole (2.8+/-0.2 versus 4.7+/-0.5 days of therapy to reach the first day with satisfactory heartburn relief, p=0.0045 at log-rank test). In the maintenance phase, 15.2% of patients had an endoscopic and/or clinical relapse.Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase.
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- 2005
12. Milan multicenter experience in 96 liver transplants for hepatitis B virus-related cirrhosis
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Caccamo, L., Belli, L. S., VINCENZO MARIA MAZZAFERRO, Colledan, M., Alberti, A., Regalia, E., Fassati, L. R., Ideo, G., Rubino, A., Belli, L., Gennari, L., Galmarini, D., Caccamo, L, Belli, L, Mazzaferro, V, Colledan, M, Alberti, A, Regalia, E, Fassati, L, Ideo, G, Rubino, A, Gennari, L, and Galmarini, D
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Adult ,Liver Cirrhosis ,Male ,Time Factors ,Adolescent ,Hepacivirus ,Virus Replication ,Humans ,human ,Hepatitis B e Antigens ,conference paper ,long term care ,Hepatitis B Surface Antigens ,virus pathogenesi ,liver cirrhosi ,human cell ,clinical trial ,Middle Aged ,Hepatitis B ,major clinical study ,human tissue ,Liver Transplantation ,multicenter study ,priority journal ,Italy ,Female ,hepatitis b viru ,recurrence risk ,Follow-Up Studies - Published
- 1994
13. Sandimmun-Neoral in liver transplantation: a remarkable improvement in long-term immunosuppression
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Belli, L. S., De Carlis, L., Rondinara, G. F., Alberti, A., Rossetti, O., Zurleni, F., Bellati, G., Fesce, E., Zoppi, F., Airoldi, A., Ideo, G., Belli, L., Belli, L, De Carlis, L, Rondinara, G, Alberti, A, Rossetti, O, Zurleni, F, Bellati, G, Fesce, E, Zoppi, F, Airoldi, A, and Ideo, G
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Adult ,Liver Cirrhosis ,Male ,Transplantation ,Intestinal Absorption ,Cyclosporine ,Administration, Oral ,Humans ,Surgery ,Female ,Middle Aged ,Hepatitis C ,Liver Transplantation - Published
- 1994
14. Neoral in liver transplant patients: pharmacokinetic study and clinical implications
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Belli, L. S., Slim, O. A., Carlis, L., Rondinara, G. F., Alberti, A., Zoppi, F., Bellati, G., Fesce, E., Airoldi, A., Colombo, D., Di Gregorio, M., Ideo, G., Belli, L., Belli, L, Slim, O, De Carlis, L, Rondinara, G, Alberti, A, Zoppi, F, Bellati, G, Fesce, E, Airoldi, A, Colombo, D, Di Gregorio, M, and Ideo, G
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Immunosuppression Therapy ,Transplantation ,Time Factors ,Administration, Oral ,Biological Availability ,Fasting ,Liver Transplantation ,Eating ,Treatment Outcome ,Intestinal Absorption ,Cyclosporine ,Gelatin ,Humans ,Surgery ,Follow-Up Studies - Published
- 1994
15. The prediction of coronary heart disease mortality as a function of major risk factors in over 30000 men in the Italian RIFLE Pooling Project. A comparison with the MRFIT primary screenees
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MENOTTI A, FARCHI G, SECCARECCIA F, THE RIFLE RESEARCH GROUP, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDARO S, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, SPAGNOLO A, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, Menotti, A, Farchi, G, Seccareccia, F, THE RIFLE RESEARCH, Group, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addaro, S, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Spagnolo, A, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .
- Published
- 1994
16. Recurrence of HDV infection after liver transplantation
- Author
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Bettale, G., Alberti, A., Belli, L. S., Rondinara, G., De Carlis, L., Vai, C., Zavaglia, C., Belli, L., Ideo, G., Bettale, G, Alberti, A, Belli, L, Rondinara, G, De Carlis, L, Vai, C, Zavaglia, C, and Ideo, G
- Subjects
Adult ,Liver Cirrhosis ,Male ,Hepatitis B Surface Antigens ,Medicine (all) ,Middle Aged ,Hepatitis B ,Hepatitis D ,Liver Transplantation ,Recurrence ,Humans ,Female ,Hepatitis B Vaccines ,Hepatitis Antibodies ,Hepatitis B Antibodies ,Hepatitis Delta Virus - Published
- 1993
17. Presentation of the RIFLE Project Risk Factors and Life Expectancy
- Author
-
THE RIFLE RESEARCH GROUP, MENOTTI A, FARCHI G, CONTI S, GIAMPAOLI S, LANTI M, MARIOTTI S, SCANGA M, SECCARECCIA F, SPAGNOLO A, VERDECCHIA A, DI CARLO G, DIMA F, MARENCO G, FALCHERO M, IDEO G, PODDA M, FERRARIO M, CESANA GC, TENCONI MT, LADDOMADA MS, DOBRILLA G, DE PETRIS G, ANGELINI GP, OCKOLICSANYI L, TOSO S, AMBROSIO GB, TASSO S, BITTOLO BON G, ALESSANDRINI P, FERUGLIO GA, VANUZZO D, CARULLI N, SALVIOLI GF, GADDI A, D'ADDATO S, DESCOVICH GC, DORMI A, BARBARA L, ALVISI V, BUZZELLI GP, GIACCHI M, LAURENZI M, RICCI G, ANTONINI R, ANGELICO F, LALLONI L, ATTILI AF, URBINATI GC, MANCINI M, PANICO S, FARINARO E, ALBANO O, MISCIAGNA G, MUNTONI S, STABILINI L, AVELLONE G, DI GARBO G. ., DEVOTI, Gabriele, THE RIFLE RESEARCH, Group, Menotti, A, Farchi, G, Conti, S, Giampaoli, S, Lanti, M, Mariotti, S, Scanga, M, Seccareccia, F, Spagnolo, A, Verdecchia, A, DI CARLO, G, Dima, F, Marenco, G, Falchero, M, Ideo, G, Podda, M, Ferrario, M, Cesana, Gc, Tenconi, Mt, Laddomada, M, Devoti, Gabriele, Dobrilla, G, DE PETRIS, G, Angelini, Gp, Ockolicsanyi, L, Toso, S, Ambrosio, Gb, Tasso, S, BITTOLO BON, G, Alessandrini, P, Feruglio, Ga, Vanuzzo, D, Carulli, N, Salvioli, Gf, Gaddi, A, D'Addato, S, Descovich, Gc, Dormi, A, Barbara, L, Alvisi, V, Buzzelli, Gp, Giacchi, M, Laurenzi, M, Ricci, G, Antonini, R, Angelico, F, Lalloni, L, Attili, Af, Urbinati, Gc, Mancini, M, Panico, S, Farinaro, E, Albano, O, Misciagna, G, Muntoni, S, Stabilini, L, Avellone, G, and DI GARBO, G. .
- Published
- 1993
18. PEG-IFN alfa-2a (40KD) (Pegasys) plus amantadine (AMA) or ribavirin (RBV) in naive patients with chronic hepatitis C
- Author
-
Ideo, G., Giuseppe, S., Attili, Adolfo Francesco, Chirianni, A., Craxi, A., Di Perri, G., Picciotto, A., Rizzetto, M., Ruggiero, G., Suter, F., and Sarracino, M.
- Published
- 2002
19. Experience of the first 100 liver transplantations at the Niguarda Hospital in Milan [ESPERIENZA DEI PRIMI 100 TRAPIANTI EPATICI A MILANO-NIGUARDA]
- Author
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Belli, L., De Carlis, L., Bettale, G., Del Favero, E., Rondinara, G., Ideo, G., Santandrea, E., Belli, L, De Carlis, L, Bettale, G, Del Favero, E, Rondinara, G, Ideo, G, and Santandrea, E
- Subjects
Surgery - Abstract
From December 1985 to December 1990 100 orthotopic liver transplantations were performed in 89 adult patients in the Department of Transplantation, Niguarda Hospital, Milan. Techniques of donor's and recipient's operation were, with some modifications, those described by Starzl and associates. Patients were divided into two series (the first 32 OLTX and the last 68) on the basis of substantial variation occurred in operative indications, graft preservation and immunosuppression. Cumulative survival was 63% after 12 months, 46% after 36 and 42 months; in the second group it was 78% after 12 and 24 months. In neoplastic patients survival was 49% at 18 months and 23% at 36 and 42 months; in the second group, however, which included 5 occasional findings in cirrhotic patients, survival at 24 months was markedly better (83%). Out of 13 patients who were HBsAg positive before OLTX with a follow-up of more than 3 months, 10 were anti-HDV positive. Five (38%) had HBV recurrence (4 co-infection HBV-HDV), 1 with histological picture of active liver cirrhosis after 8 months. The other 8 patients did not evidence recurrence. Six patients underwent OLTX for acute fulminant hepatitis and all were negative for HGsAg and anti-HCV: 3 survived and are in good condition. Survival was markedly influenced by the preoperative status of the patients and by intraoperative blood loss. The improved survival in the second group is accounted for, in conclusion, by a better surgical/intensive care experience and methodological differences: 1. emergency operations in terminal patients are now limited; 2. selection criteria are much more restrictive; 3. actual preservation solutions allow improved graft function; 4. multidrug immunosuppression permit a better control of rejection
- Published
- 1991
20. LAMIVUDINE TREATMENT FOR ACUTE HEPATITIS B AFTER LIVER TRANSPLANTATION
- Author
-
Andreone, P, Caraceni, P, Grazi, Gl, Belli, L, Milandri, Gl, Ercolani, G, Jovine, E, D'Errico, A, DAL MONTE PR, Ideo, G, Forti, D, and Mazziotti, A
- Published
- 1998
21. Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of data from European Centers
- Author
-
Schalm, Sw, Hausen, Be, Chemello, Liliana, Bellobuono, A, Brouwer, Jt, Weiland, O, Cavalletto, L, Schvarcz, R, Ideo, G, and Alberti, Alfredo
- Published
- 1997
22. Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Meta-analysis of individual patient data from European centers
- Author
-
Schalm, Solko, Hansen, Bettina, Chemello, L, Bellobuono, A, Brouwer, JT, Weiland, O, Cavalletto, L, Schvarcz, R, Ideo, G, Alberti, A, Internal Medicine, and Epidemiology
- Subjects
Adult ,Male ,Alanine Transaminase ,Drug Synergism ,Hepacivirus ,Middle Aged ,Hepatitis C ,Hemoglobins ,SDG 3 - Good Health and Well-being ,Chronic Disease ,Ribavirin ,Humans ,RNA, Viral ,Drug Therapy, Combination ,Female ,Interferons ,Randomized Controlled Trials as Topic - Abstract
This study aimed to obtain a more precise estimation of the efficacy and tolerability of interferon-ribavirin combination therapy for chronic hepatitis C.A meta-analysis was carried out of individual patient data comprising about 90% of the published experience with combination therapy. The study was set in four European university-affiliated liver referral centers. A total of 186 individuals with chronic hepatitis C who had participated in three randomized controlled trials and one open study were selected for the study. Fifty-one had received ribavirin monotherapy (1000-1200 mg/day), 37 interferon monotherapy (3 MU 3x/week) and 78 interferon-ribavirin combination therapy (dosage as for monotherapy) for 6 months. Twenty patients served as controls. Follow-up after therapy was 6 months. Data analysis was by the multivariate logistical regression method.The primary outcome measure for efficacy was the percentage with a sustained response (ALT normalization and HCV RNA negativity 6 months after therapy). The sustained response rate was significantly higher for interferon-ribavirin combination therapy than for interferon or ribavirin monotherapy (odds ratio IFN-Riba vs IFN = 9.8, 95% CI 1.9-50). The estimated probability of sustained response following interferon-ribavirin combination therapy was 51% for patients without previous IFN therapy, 52% for patients with previous IFN therapy and response-relapse, and 16% for previous IFN non-responders. No serious adverse events were observed and less than 10% withdrew.The efficacy of interferon-ribavirin therapy appears to be enhanced two- to threefold over interferon monotherapy in all major subgroups of chronic hepatitis C patients tested. In view of its acceptable toxicity profile, interferon-ribavirin combination therapy is a candidate for the new standard therapy for chronic hepatitis C.
- Published
- 1997
23. A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody--and hepatitis B virus DNA--positive chronic hepatitis B
- Author
-
Andreone, P, Cursaro, C, Gramenzi, A, Zavagliz, C, Rezakovic, I, Altomare, E, Severini, R, Franzone, Js, Albano, O, Ideo, G, Bernardi, M, and Gasbarrini, G.
- Published
- 1996
24. A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon
- Author
-
Fattovich, G., Giustina, G., Favarato, S., Ruol, A., Macarri, G., Orlandi, E., Iaquinto, G., Ambrosone, L., Francavilla, A., Pastore, G., Santantonio, M. T., Romagno, D., Bolondi, L., Sofia, S., Marchesini, A., Pisi, E., Mazzella, G., Roda, E., Attaro, L., Chiodo, E., Mori, E., Verucchi, G., Lanzini, A., Salmi, A., Calvi, B., Bozzetti, E., Radaeli, E., Bernasconi, M., Pilleri, G., Bacca, D., Romano, G., Mastrapasqua, G., Cozzolongo, R., Cacopardo, B., Nunnari, A., Blasi, A., Sala, L. O., Minoli, G., Sangiovanni, A., Spinzi, G. C., Colombo, A., Camassa, M., Riva, D., Maggi, G., Boccia, S., Gualandi, G., Nucci, A., Pacini, F., Marino, N., Mazzotta, E., La Mura, A., Pompei, A. G., Casinelli, K., Petrosillo, N., Giacchino, R., Timitilli, A., Spiga, E., Corsetti, M., Menicagli, V., Tucci, A., Bissoli, E., Raimondo, G., Rodino, G., Bellobuono, A., Ideo, G., Colombo, M., Pacchetti, S., Rumi, M. R., Battezzati, P. M., Bruno, S., Podda, M., Zuin, M., Fargion, S., Fiorelli, G., Gellmann, E., Vandelli, C., Ventura, E., Manenti, F., Villa, E., Caporaso, N., Coltorti, M., Morisco, E., Del Vecchio-Blanco, C., di Santolo, S. S., Di Nunzio, S., Ruggiero, G., Zampino, R., Ascione, A., De Luca, M., Galeota-Lanza, A., Aprea, L., Sagnelli, E., Felaco, E. M., Piccinino, E., Ballare, M., Monteverde, A., Tappero, G., Sanna, G., Alberti, A., Bonetti, P., Casarin, C., Diodati, G., Tremolada, E., Naccarato, R., Chiaramonte, M., Floreani, M. R., Almasio, P., Craxi, A., Loiacono, O., Pagliaro, L., Fiaccadori, E., Giuberti, T., Belloni, G., Bernardini, E., Buscarini, L., Sbolli, G., Giudici-Cipriani, A., Marenco, G., Mazzaro, C., Massari, M., Fornaciari, G., Plancher, A., Gasbarrini, G., Grieco, A., Luchetti, R., Rapaccini, G. L., Bombardieri, G., Di Virgilio, D., Bruno, G., Ricci, G. L., Hassan, G., Mari, T., Scalisi, I., Colloredo, G., Frunzio, A., Tabone, M., Costa, C., Rosina, E., Saracco, G., Verme, G., Frezza, M., Urban, E., Capra, E., Casaril, M., Corrocher, R., and Benetti, G. P.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Hepatitis, Viral, Human ,Alpha interferon ,Poison control ,Chronic viral hepatitis ,Interferon alfa ,Side effects ,Gastroenterology ,Autoimmune Diseases ,Internal medicine ,Medicine ,Humans ,Adverse effect ,Child ,Aged ,Retrospective Studies ,Hepatitis ,Hepatology ,business.industry ,Thyroid disease ,Mental Disorders ,Infant, Newborn ,Infant ,Middle Aged ,medicine.disease ,Recombinant Proteins ,Surgery ,Bone marrow suppression ,Child, Preschool ,Chronic Disease ,Interferon Type I ,Female ,business ,Viral hepatitis ,medicine.drug - Abstract
Aims: The aim of this study was to assess the incidence of fatal, life-threatening side effects and the de novo appearance of non-hepatic morbidity during interferon alfa therapy for chronic viral hepatitis. The relationship of these adverse events to actual total dose and duration of interferon was also evaluated. Methods: We conducted a retrospective study at 73 Italian centers of 11 241 consecutive patients with chronic vital hepatitis who underwent interferon alfa treatment. Results: Five patients died during interferon therapy due to liver failure ( n =4) or complications arising from sepsis. Life-threatening side effects were observed in eight patients: two cases where depression developed and led to a suicide attempt and six patients with bone marrow suppression (granulocytes 3 or platelets 3 ). These symptoms and signs completely disappeared after interferon withdrawal. During interferon treatment, 131 patients developed the following de novo non-hepatic disorders: symptomatic thyroid disease ( n =71), impotence ( n =5), systemic autoimmune disease ( n =5), immune-mediated dermatologic disease ( n =14), diabetes mellitus ( n =10), cardiovascular disease ( n =7), psychosis n =10), seizures ( n =4), peripheral neuropathy ( n =3) and hemolytic anemia ( n =2). Most of these complications are reversible or can be ameliorated. Fatal or life-threatening side effects were not related to actual total dose or duration of interferon alfa, while the majority of patients with de novo non-hepatic morbidity received medium/high doses ( > 200 million units) of interferon alfa or were treated for periods longer than 16 weeks (68% and 80%, respectively). Conclusions: Treatment with interferon alfa may have fatal or life-threatening side effects, their incidence in this study being low (0.04% and 0.07%, respectively) and perhaps no different than in untreated patients with chronic viral hepatitis. Moreover de novo non-hepatic morbidity occurred in 1.2% of patients, and the dose and duration of interferon therapy seem important in determining the frequency of this complication. The development of clinically-overt thyroid disease was most common.
- Published
- 1996
25. Liver transplantation in Italy: Preliminary 10-year report
- Author
-
Fagiuoli, S., Leandro, G., Bellati, G., Gasbarrini, A., Rapaccini, Gl, Pompili, M., Rendina, M., Denotariis, S., Francavilla, A., Gasbarrini, G., Ideo, G., Naccarato, R., Agnes, S., Castagneto, M., Angeli, P., Angelico, M., Ascione, A., Calise, F., Bertocchi, M., Dardano, G., Borzio, M., Budillon, G., Burra, F., Farinati, F., Cadeo, Gp, Camisasca, M., Podda, M., Paolo, S., Cavallari, A., Mazziotti, A., Casciani, Cu, Tisone, G., Cillo, U., Damico, D., Colombo, M., Donato, F., Conoscitore, P., Coppolecchia, P., Dessanti, A., Fassati, Lr, Lucianetti, A., Rossi, G., Forti, D., Belli, L., Rondinara, Gf, Gaeta, G., Piccinino, F., Gerunda, G., Faccioli, Am, Gridelli, B., Guariso, G., Zancan, L., Gullini, F., Boccia, S., Jemmolo, Rm, Marcellini, M., Marzano, Ma, Marzio, L., Mazzaferro, V., Regalia, E., Morelli, Mc, Pagliaro, L., Palazzo, U., Piras, MR, Ricci, Gl, Salmi, A., Sama, C., Sangiovanni, A., Salizzoni, M., Marzano, A., Smedile, A., Rizzetto, M., Solinas, A., Spina, Gp, Stefanini, Gf, PIETRO ANDREONE, Villa, E., and Zignego, L.
- Subjects
Settore MED/12 - Gastroenterologia ,liver transplantation ,liver disease ,rejection - Published
- 1996
26. Interferon-ribavirin combination therapy for chronic hepatitis C
- Author
-
Schalm, Sw, Brouwer, Jt, Chemello, Liliana, Alberti, Alfredo, Bellobuono, A, Ideo, G, Schwartz, R, and Weiland, O.
- Published
- 1996
27. Role of IgM antibody to hepatitis B core antigen in the diagnosis of hepatitis B exacerbations
- Author
-
Colloredo Mels, G., Bellati, G., Leandro, G., Brunetto, M. R., Vicari, O., Piantino, P., Borzio, M., Angeli, G., Ideo, G., and Ferruccio Bonino
- Subjects
Adult ,Male ,Adolescent ,Alanine Transaminase ,Middle Aged ,Hepatitis B ,Hepatitis B Core Antigens ,Immunoenzyme Techniques ,Immunoglobulin M ,Predictive Value of Tests ,Carrier State ,Chronic Disease ,Humans ,Female ,Reagent Kits, Diagnostic ,Hepatitis B Antibodies ,Aged ,Follow-Up Studies - Abstract
IgM anti-HBc levels were measured by the IMx Core-M Abbott assay in 939 serum samples in order to define a specific and sensitive cut-off value for diagnosis of chronic hepatitis B. The sera used were obtained from 52 chronic HBV patients and 10 HBV carriers with HCV or HDV co-infections and 155 asymptomatic subjects without evidence of liver disease. A Youden index value of 95.4% with 98% sensitivity and 97.4% specificity was obtained for an IMx Index value of 0.204 as cut-off. A one-year follow-up study with monthly tests has shown that quantitative analysis of IgM anti-HBc can serve as a noninvasive tool for monitoring HBV infection, and provides an accurate diagnosis of hepatitis B exacerbations. Significant elevations of IgM anti-HBc levels were associated with hepatitis B exacerbations in 96.2% of the cases but with none of the ALT flare-ups observed in HCV or HDV infected individuals. These results suggest that quantitative analysis of IgM anti-HBc provides the highest degree of confidence in definition of spontaneous and therapy-induced exacerbations or remissions of hepatitis B.
- Published
- 1993
28. PRESENTATION OF THE RIFLE PROJECT RISK-FACTORS AND LIFE EXPECTANCY
- Author
-
Menotti, A., Farchi, G., Conti, S., Giampaoli, S., Lanti, M., Mariotti, S., Scanga, M., Seccareccia, F., Spagnolo, A., Verdecchia, A., Dicarlo, G., Dima, F., Marenco, G., Falchero, M., Ideo, G., Caspani, B., Podda, M., Zuin, M., Ferrario, M., Cesana, Gc, Devito, G., Sega, R., Tenconi, Mt, Laddomada, Ms, Devoti, G., Dobrilla, G., Depetris, G., Angelini, Gp, Okolicsanyi, L., Toso, S., Nassuato, G., Passera, D., Ambrosio, Gb, Tasso, S., Bittolobon, G., Moro, E., Alessandrini, P., Soldan, S., Feruglio, Ga, Vanuzzo, D., Pilotto, L., Carulli, N., Loria, P., Dilengite, M., Bozzoli, M., Salvioli, Gf, Lugli, R., Gaddi, A., Sangiorgi, Z., Daddato, S., Minardi, A., Descovich, Gc, Dormi, A., Barbara, L., Festi, D., Alvisi, V., Balhous, W., Buzzelli, Gp, Giusti, A., Giacchi, M., Fatighenti, D., Giotti, M., Laurenzi, M., Ricci, G., Bucci, A., Antonini, R., Pacioni, F., Angelico, F., Delben, M., Lalloni, L., Azzarri, L., Ricci, P., Attili, Fa, Desantis, A., Urbinati, Gc, Fazio, S., Pannozzo, F., Sotis, Gl, Righetti, Gm, Mancini, M., Farinaro, E., Panico, S., Trevisan, M., Krogh, V., Jossa, F., Celentano, E., Rocco Galasso, Albano, O., Palasciano, G., Misciagna, G., Guerra, V., Muntoni, S., Pintus, P., Podda, E., Stabilini, M., Frulio, T., Brotzu, G., Pulina, S., Trudu, A., Sanna, A., Baule, Gm, Avellone, G., and Digarbo, V.
- Subjects
RISK FACTORS, LIFE EXPECTANCY, MORTALITY, PREDICTION - Published
- 1993
29. Chromatographic Studies on Leucine Aminopeptidase in Normal Human Granulocytes and in Cells of Acute and Chronic Myeloid Leukemia
- Author
-
Dioguardi N, Tittobello A, Agostoni A, Ideo G, and Fiorelli G
- Subjects
Chromatography ,Blood Chemical Analysis ,Leukemia ,Chemistry ,Myeloid leukemia ,General Medicine ,Aminopeptidases ,Aminopeptidase ,Leucyl Aminopeptidase ,Biochemistry ,Leucine ,Leukemia, Myeloid ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,Immunology ,Leukocytes ,Humans ,Granulocytes - Published
- 1963
30. Cyclosporin monotherapy (after 3 months) in liver transplant patients: A prospective randomized trial
- Author
-
Romani, F., Belli, L. S., De Carlis, L., Rondinara, G. F., Alberti, A., Sansalone, C. V., Bellati, G., Zavaglia, C., Fesce, E., Ideo, G., Belli, L., Romani, F, Belli, L, De Carlis, L, Rondinara, G, Alberti, A, Sansalone, C, Bellati, G, Zavaglia, C, Fesce, E, and Ideo, G
- Subjects
Adult ,Graft Rejection ,Immunosuppression Therapy ,Male ,Transplantation ,Incidence ,Middle Aged ,Liver Transplantation ,Survival Rate ,Acute Disease ,Chronic Disease ,Cyclosporine ,Humans ,Female ,Steroids ,Surgery
31. Recurrent hepatitis C after liver transplantation
- Author
-
Belli, L. S., Alberti, A., Rondinara, G. F., De Carlis, L., Romani, F., Bellati, G., Minola, E., Zurleni, F., Rossetti, O., Pirotta, V., Rimoldi, P., Asti, L., Ideo, G., Belli, L., Belli, L, Alberti, A, Rondinara, G, De Carlis, L, Romani, F, Bellati, G, Minola, E, Zurleni, F, Rossetti, O, Pirotta, V, Rimoldi, P, Asti, L, and Ideo, G
- Subjects
Transplantation ,Biopsy ,Alanine Transaminase ,Bilirubin ,Enzyme-Linked Immunosorbent Assay ,Hepatitis C Antibodies ,Hepatitis C ,Liver Transplantation ,Postoperative Complications ,Recurrence ,Humans ,Surgery ,Blood Transfusion ,Hepatitis Antibodies ,Follow-Up Studies ,Retrospective Studies
32. Tauroursodeoxycholic acid for the treatment of HCV-related chronic hepatitis: A multicenter placebo-controlled study
- Author
-
Crosignani, A., Budillon, G., Cimino, L., Del Vecchio Blanco, C., Carmelina LOGUERCIO, Ideo, G., Raimondo, G., Stabilini, R., Podda, M., Crosignani, A, Budillon, G, Cimino, L, DEL VECCHIO BLANCO, C, Loguercio, Carmelina, Ideo, G, Raimondo, G, Stabilini, R, and Podda, M.
- Subjects
Male ,Taurochenodeoxycholic Acid ,Double-Blind Method ,Humans ,Alanine Transaminase ,Female ,Aspartate Aminotransferases ,gamma-Glutamyltransferase ,Clinical Enzyme Tests ,Hepatitis C, Chronic ,Middle Aged - Abstract
Tauroursodeoxycholic acid is a promising drug for the treatment of chronic cholestatic liver diseases since it has more favourable physicochemical and metabolic properties than ursodeoxycholic acid. Tauroursodeoxycholic acid may be of benefit also for necroinflammatory liver disease, especially for HCV-related chronic hepatitis in which bile duct damage and some degree of cholestasis are frequently seen at histology.One hundred and fifty patients with chronic hepatitis were randomly assigned to receive tauroursodeoxycholic acid at daily doses of 500 mg or 750 mg, or a placebo for 6 months.A consistent decrease in aminotransferase serum levels was observed in patients treated with tauroursodeoxycholic acid compared with placebo (p0.001) and a progressive improvement with time was also found (p0.05; linear time effect).Tauroursodeoxycholic acid improves the biochemical expression of chronic hepatitis. Long-term studies with clinically relevant end-points are warranted.
33. Lactate dehydrogenase (LDH), glutamic oxalacetic transaminase (GOT) and malate dehydrogenase (MDH) isoenzymes in lymphocytes from foetal and adult thymus, spleen and from peripheral blood
- Author
-
Dioguardi N, P. M. Mannucci, Fiorelli G, and Ideo G
- Subjects
Adult ,Electrophoresis ,Chromatography ,L-Lactate Dehydrogenase ,Spleen ,General Medicine ,Thymus Gland ,Isozyme ,Malate dehydrogenase ,Peripheral blood ,Transaminase ,Isoenzymes ,chemistry.chemical_compound ,medicine.anatomical_structure ,Fetus ,chemistry ,Biochemistry ,Malate Dehydrogenase ,Lactate dehydrogenase ,medicine ,Humans ,Aspartate Aminotransferases ,Lymphocytes - Published
- 1966
34. Fibronectin, cholesterol and triglycerides ascitic fluid concentration in the prediction of malignancy
- Author
-
Colloredo Mels G, Bellati G, Auriemma L, Perani C, Gioacchino Leandro, Vacca N, Pinna N, Alfieri G, and Ideo G
- Subjects
Adult ,Liver Cirrhosis ,Male ,Carcinoma, Hepatocellular ,Adolescent ,Liver Neoplasms ,Middle Aged ,Sensitivity and Specificity ,Fibronectins ,Diagnosis, Differential ,Cholesterol ,ROC Curve ,Predictive Value of Tests ,Biomarkers, Tumor ,Ascitic Fluid ,Humans ,Female ,Child ,Triglycerides ,Aged - Abstract
There have been few trials comparing the efficacy of determinations of cholesterol, fibronectin and triglycerides for diagnosis of malignant ascites. In this study we measured these in 200 ascitic fluids from 93 cirrhotic patients (Group A), 47 hepatocellular-carcinoma patients (Group B), 60 extra-hepatic tumour patients (Group C), 44 of them with malignant cells (Group Cpos) and 16 without (Group Cneg). Anova one-way and the Bonferroni test for multiple comparisons showed that fibronectin and cholesterol were significantly higher in the ascitic fluids of patients of group C than of groups A and B (mean +/- ESM) (Cholesterol in A: 27.2 +/- 2.8; in B 23.5 +/- 1.5; in C: 68.6 +/- 5.3 mg/dl. Fibronectin in A: 32.7 +/- 2.8; in B 31.3 +/- 2.6; in C 127.7 +/- 11.1 mg/l). Both were significantly higher in Group Cpos than in Group Cneg (Cholesterol in Cneg: 41.2 +/- 6.7; in Cpos: 78.6 +/- 6.2 mg/dl. Fibronectin in Cneg: 55.0 +/- 11.2; in Cpos 154 +/- 12.3 mg/dl). We found no differences between cirrhotic ascites and malignant ascites due to primary liver hepatocellular-carcinoma. No difference at all in triglycerides were detected. With the Receiver-Operating Characteristic (ROC) curve, cholesterol had the best Youden Index (57%) at a cut-off of 32 mg/dl (sensitivity 78.3%, specificity 79.3% at this level); the best Youden Index (64%) for fibronectin had a cut-off of 60 mg/dl (sensitivity 65%, specificity 89.3%). Triglycerides appeared to be a great deal less effective as a diagnostic marker, with their best Youden Index (23%) at a cut-off 32 mg/dl (sensitivity 66.7%, specificity 56.4%).(ABSTRACT TRUNCATED AT 250 WORDS)
35. Guidelines for the treatment of chronic viral hepatitis
- Author
-
Alberti, A., Almasio, P., Ascione, A., Bianchi, F., Bonino, F., Caporaso, N., Colombo, M., Craxi, A., VITO DI MARCO, Fattovich, G., Ferrari, C., Ideo, G., Levrero, M., Raimondo, G., Rizzetto, M., and Smedile, A.
- Subjects
chronic hepatitis B ,chronic hepatitis C ,guidelines for therapy
36. The prediction of coronary heart disease mortality as a function of major risk factors in over 30000 men in the italian RIFLE pooling project. A comparison with the MRFIT primary screenees
- Author
-
Menotti, A., Farchi, G., Seccareccia, F., Conti, S., Giampaoli, S., Lanti, M., Mariotti, S., Scang, M., Spagnolo, A., Verdecchia, A., Di Carlo, G., Dima, F., Marenco, G., Falchero, M., Ideo, G., Caspani, B., Podda, M., Zuin, M., Ferrario, M., Cesana, G. C., Vito, G., Sega, R., Tenconi, M. T., Laddomada, M. S., Gabriele DEVOTI, Dobrilla, G., Petris, G., Angelini, G. P., Okolicsanyi, L., Toso, S., Nassuato, G., Passera, D., Ambrosio, G. B., Tasso, S., Bittolo-Bo, G., Moro, E., Alessandrini, P., Soldan, S., Feruglio, G. A., Vanuzzo, D., Pilotto, L., Carulli, N., Loria, P., Dilengite, M., Bozzoli, M., Salvioli, G. F., Lugli, R., Gadd, A., Sangiorg, Z., D’addat, S., Minard, A., Descovich, G. C., Dormi, A., Barbara, L., Festi, D., Alvisi, V., Balhous, W., Buzzelli, G. B., Giusti, A., Giacchi, M., Fatighenti, D., Giotti, M., Laurenzi, M., Ricci, G., Bucci, A., Antonini, R., Pacioni, F., Angelico, F., Del Ben, M., Lalloni, L., Azzarri, L., Ricci, P., Attili, F. A., Santis, A., Urbinati, G. C., Fazio, S., Pannozzo, F., Sotis, C. L., Righetti, G. M., Mancini, M., Farinaro, E., Panico, S., Trevisan, M., Krogh, V., Jossa, F., Celentano, E., Galasso, R., Albano, O., Palasciano, G., Misciagna, G., Guerra, V., Muntoni, S., Pintus, P., Podda, E., Stabilini, M., Frulio, T., Pulina, S., Trudu, A., Sanna, A., Baule, G. M., Avellone, G., and Di Garbo, V.
37. Abstinence-induced oxidative stress in moderate drinkers is improved by bionormalizer
- Author
-
Francesco Marotta, Reizakovic I, Tajiri H, Safran P, and Ideo G
- Subjects
Adult ,Male ,Alcoholism ,Oxidative Stress ,Ethanol ,Humans ,Female ,Food, Organic ,Free Radical Scavengers ,Middle Aged ,Thiobarbituric Acid Reactive Substances ,Substance Withdrawal Syndrome - Abstract
The aim of this investigation was to study the oxidative phenomena which take place in the early recovery phase after alcohol withdrawal. Furthermore, the effects of a novel natural antioxidant, Bionormalizer (BN), in such a clinical setting was studied.Forty-six alcoholics with moderate drinking habits (daily ethanol intake:80g to120g) were enrolled in the study, divided into two groups and given either a placebo or 9g of BN by mouth every night for one week. The patients agreed to stop drinking alcohol, and daily blood sampling was obtained for routine tests and to check plasma and erythrocyte levels of MDA, SOD, GPX and the hydroperoxide level. The groups were comparable in terms of initial biochemical parameters.BN prevented the early increase of plasma TBARS observed in the placebo group, enabling a near-to-normal level of plasma and erythrocyte MDA by the fourth day. BN also prevented the significant drop of erythrocyte GPX and the transient decrease of plasma SOD observed in the placebo group. Despite alcohol withdrawal, plasma lipid hydroperoxide remained significantly elevated in the placebo group, but this phenomenon was rapidly improved by BN.To a significant extent, BN is able to prevent the free radical-mediated lipoperoxidative changes that occur soon after alcohol withdrawal, while fastening the recovery mechanisms.
38. Beta-adrenergic-antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices: An analysis of data and prognostic factors in 589 patients from four randomized clinical trials
- Author
-
Aitoussy, S., Amuso, M., Aubin, J. -P, Bauret, P., Bellati, G., Benhamou, J. -P, Blanc, F., Bockel, R., Bommelear, G., Botta, D., Cabarrot, P., Caltagirone, M., Calès, P., Calés, P., Capron, J. -P, Champigneulle, B., Chaput, J. -C, Cipriani, A. G., Colin, R., Cottone, M., D Amico, G., Dabadie, H., Dante, G., Dapoigny, M., Pratis, G., Delmont, J., Descos, L., Di Piazza, S., Doffoel, M., Duclos, B., Ferrari, A., Fesce, E., Filippazzo, M. G., Fratini, G., Gatto, G., Gaucher, P., Gauthier, A., Geoffroy, P., Giannuoli, G., Grimoldi, D., Hillon, P., Ideo, G., Jutel, P., Lamouliatte, H., Le Bodic, L., Le Bourgeois, P., Le Marchand, P., Le Moli, S., Lebrec, D., Lemba, C., Magrin, S., Marceno, M. P., Marenco, G., Margulies, A., Marin-Lafleche, J. -P, Maringhini, A., Menardo, G., Merighi, A., Metman, E. -H, Michel, H., Monin, E., Morabito, A., Mudry, J., Oberhollenzer, F., Paccalin, J., Pagliaro, L., Palazzo, U., Paris, J. -C, Parlier, H., Pascal, J. -P, Pasta, L., Patouillard, B., Patouillard, G., Piazzi, L., Pillegand, B., Pinzello, G., Thierry Poynard, Quinton, A., Rachail, M., Rigo, G., Rivet, A., Roulot, D., Rueff, B., Sautereau, D., Sciarrino, E., Scotto, J. -M, Simonetti, R. G., Steiner, H., Tine, F., Traina, M., Trouvez, J. -L, Turri, M., Valentini, M., Vinci, M., Vinel, J. -P, Virdone, R., Vizzini, G., Weill, J. -P, and Zarski, J. -P
39. Liver transplantation in Italy: Preliminary 10-year report
- Author
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Fagiuoli, S., Leandro, G., Bellati, G., Gasbarrini, A., Rapaccini, Gl, Pompili, M., Rendina, M., Denotariis, S., Francavilla, A., Gasbarrini, G., Ideo, G., Naccarato, R., Castagneto M, Agnes S., Paolo Angeli, Angelico, M., Ascione, A., Calise, F., Bertocchi, M., Dardano, G., Borzio, M., Budillon, G., Burra, F., FABIO FARINATI, Cadeo, Gp, Camisasca, M., Podda, M., Paolo, S., Cavallar, A., Mazziotti, A., Casciani, Cu, Tisone, G., Umberto Cillo, Damico, D., Colombo, M., Donato, F., Conoscitore, P., Coppolecchia, P., Dessanti, A., Fassati, Lr, Lucianetti, A., Rossi, G., Forti, D., Belli, L., Rondinara, Gf, Gaeta, G., Piccinino, F., Gerunda, G., Faccioli, Am, Gridelli, B., Guariso, Graziella, Zancan, L., Gullini, F., Boccia, S., Jemmolo, Rm, Marcellini, M., Marzano, Ma, Marzio, L., Mazzaferro, V., Regalia, E., Morelli, Mc, Pagliaro, L., Palazzo, U., Piras, Mr, Ricci, Gl, Salmi, A., Sama, C., Sangiovanni, A., Salizzoni, M., Marzano, A., Smedile, A., Rizzetto, M., Solinas, A., Spina, Gp, Stefanini, Gf, Andreone, P., Villa, E., and Zignego, L.
- Subjects
liver transplantation ,liver transplantation, liver disease, rejection ,rejection ,liver disease
40. Milan multicenter experience in liver transplantation for hepatitis C- related cirrhosis: Report of 105 cases
- Author
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Belli, L. S., Caccamo, L., VINCENZO MARIA MAZZAFERRO, Silini, E., Alberti, A., Melada, E., Regalia, E., Gridelli, B., Rubino, A., Gennari, L., Galmarini, D., Ideo, G., and Belli, L.
41. Both immunogenetic factors and HCV genotype can influence the outcome of chronic HCV infection [11]
- Author
-
Zavaglia, C., Belli, L. S., Alberti, A. B., Ideo, G., and Enrico M. Silini
42. Liver transplantation in Italy: preliminary 10-year report. The Monotematica Aisf-Olt Study Group
- Author
-
Fagiuoli S, Gioacchino Leandro, Bellati G, Gasbarrini A, Gl, Rapaccini, Pompili M, Rendina M, De Notariis S, Francavilla A, Gasbarrini G, Ideo G, and Naccarato R
- Subjects
Adult ,Graft Rejection ,Male ,Adolescent ,Liver Diseases ,Graft Survival ,Settore MED/09 - MEDICINA INTERNA ,Liver Transplantation ,Survival Rate ,Postoperative Complications ,Italy ,Humans ,Female ,Immunosuppressive Agents ,Follow-Up Studies ,Retrospective Studies - Abstract
Experience in liver transplantation (OLT) in Italy over a ten-year period is reported. Data were obtained using a multiple-items form collected from Italian liver transplant centres (reference centres) and other Italian institutions actively involved both in the processes of evaluation of the candidates and the follow-up of liver transplant recipients (afference centres). During this period, a total of 1046 liver transplants were performed on 954 patients, with a cumulative proportional survival of 71%. The most common indication for liver transplantation was post-hepatitic cirrhosis due to either hepatitis B virus (+/-hepatitis Delta virus) or hepatitis C virus infection. Good survival rates were observed, particularly in controversial indications, such as alcoholic cirrhosis, post-hepatitic hepatitis B virus-related cirrhosis and hepatocellular carcinoma, most likely due to proper and careful selection of the patients. Cirrhosis, secondary to an autoimmunity-based liver disease, showed the highest rate of rejection episodes. Infections, in our study population, were the most common cause of death after transplantation.
43. Recurrent HBV/HDV infections under different immunoprophylaxis protocols
- Author
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Rimoldi, P., Belli, L. S., Rondinara, G. F., ALFREDO ALBERTI, Decarlis, L., Minola, E., Pirotta, V., Meroni, A., Romani, F., Sansalone, V., Riolo, F., Pirolo, A., Ideo, G., and Belli, L.
44. Optimising the clinical strategy for autoimmune liver diseases: Principles of value-based medicine
- Author
-
Marta Gemma, Stefano Fagiuoli, Luca Fabris, Gaetano Ideo, Matteo Rota, Marco Carbone, Giancarlo Cesana, S. Okolicsanyi, Luca Maria Munari, Michele Colledan, A. Ciaccio, Paolo Cortesi, Luciana Scalone, Laura Cristoferi, Lorenzo G. Mantovani, Mario Strazzabosco, Luca S. Belli, Carbone, M, Cristoferi, L, Cortesi, P, Rota, M, Ciaccio, A, Okolicsanyi, S, Gemma, M, Scalone, L, Cesana, G, Fabris, L, Colledan, M, Fagiuoli, S, Ideo, G, Belli, L, Munari, L, Mantovani, L, and Strazzabosco, M
- Subjects
Male ,0301 basic medicine ,Delphi Technique ,Delphi method ,Autoimmune hepatitis ,Tertiary Care Centers ,0302 clinical medicine ,MED/12 - GASTROENTEROLOGIA ,Multidisciplinary approach ,Outcome Assessment, Health Care ,Prospective Studies ,Incidence ,Primary sclerosing cholangitis ,Electronic medical record ,Clinical performance ,Benchmarking ,Middle Aged ,Primary sclerosing cholangiti ,Hepatitis, Autoimmune ,Italy ,Primary biliary cholangiti ,Value-based medicine ,Critical Pathways ,Molecular Medicine ,Female ,030211 gastroenterology & hepatology ,Adult ,medicine.medical_specialty ,Primary biliary cholangitis ,Molecular Biology ,MED/42 - IGIENE GENERALE E APPLICATA ,Cholangitis, Sclerosing ,Autoimmune hepatiti ,Autoimmune Diseases ,Orphan drug ,03 medical and health sciences ,medicine ,Humans ,Intensive care medicine ,MED/01 - STATISTICA MEDICA ,Aged ,Quality Indicators, Health Care ,business.industry ,medicine.disease ,Survival Analysis ,030104 developmental biology ,business ,Follow-Up Studies - Abstract
Background Autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis represent the three major autoimmune liver diseases (AILDs). Their management is highly specialized, requires a multidisciplinary approach and often relies on expensive, orphan drugs. Unfortunately, their treatment is often unsatisfactory, and the care pathway heterogeneous across different centers. Disease-specific clinical outcome indicators (COIs) able to evaluate the whole cycle of care are needed to assist both clinicians and administrators in improving quality and value of care. Aim of our study was to generate a set of COIs for the three AILDs. We then prospectively validated these indicators based on a series of consecutive patients recruited at three tertiary clinical centers in Lombardy, Italy. Methods In phase I using a Delphi method and a RAND 9-point appropriateness scale a set of COIs was generated. In phase II the indicators were applied in a real-life dataset. Results Two-hundred fourteen patients were enrolled and followed-up for a median time of 54 months and the above COIs were recorded using a web-based electronic medical record program. The COIs were easy to collect in the clinical practice environment and their values compared well with the available natural history studies. Conclusions We have generated a comprehensive set of COIs which sequentially capture different clinical outcome of the three AILDs explored. These indicators represent a critical tool to implement a value-based approach to patients with these conditions, to monitor, compare and improve quality through benchmarking of clinical performance and to assess the significance of novel drugs and technologies. This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
- Published
- 2018
45. Clinical outcome indicators in chronic hepatitis B and C: A primer for value-based medicine in hepatology
- Author
-
Carla Fornari, P Cozzolino, Luca Maria Munari, Matteo Rota, Giancarlo Cesana, Gaetano Ideo, Stefano Fagiuoli, Marta Gemma, Paolo Cortesi, Mario Strazzabosco, Claudio Zavaglia, Giovanni Perricone, A. Ciaccio, S. Okolicsanyi, Luciana Scalone, Luca Fabris, Sara Conti, Lorenzo G. Mantovani, Michele Colledan, Luca S. Belli, Strazzabosco, M, Cortesi, P, Conti, S, Okolicsanyi, S, Rota, M, Ciaccio, A, Cozzolino, P, Fornari, C, Gemma, M, Scalone, L, Cesana, G, Fabris, L, Colledan, M, Fagiuoli, S, Ideo, G, Zavaglia, C, Perricone, G, Munari, L, Mantovani, L, and Belli, L
- Subjects
Liver Cirrhosis ,Male ,value-based Medicine ,Hepatocellular carcinoma ,Modified delphi ,Decompensated cirrhosis ,Disease ,Value Based Medicine ,Health problems ,0302 clinical medicine ,Longitudinal Studies ,Prospective Studies ,Value-Based Health Insurance ,Liver Neoplasms ,Gastroenterology ,Middle Aged ,Clinical Practice ,Treatment Outcome ,Cirrhosis ,Italy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,clinical outcome indicator ,Healthcare system ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,cirrhosis ,clinical outcome indicators ,decompensated cirrhosis ,hepatocellular carcinoma ,hepatology ,macromolecular substances ,Antiviral Agents ,03 medical and health sciences ,Hepatitis B, Chronic ,Chronic hepatitis ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Intensive care medicine ,Aged ,Quality Indicators, Health Care ,Hepatology ,business.industry ,Clinical Outcome Indicators ,decompensated cirrhosi ,fungi ,Hepatitis C, Chronic ,Survival Analysis ,Observational study ,business ,cirrhosi - Abstract
Background & Aims: Chronic liver diseases (CLDs) are major health problems that require complex and costly treatments. Liver-specific clinical outcome indicators (COIs) able to assist both clinicians and administrators in improving the value of care are presently lacking. The Value-Based Medicine in Hepatology (VBMH) study aims to fill this gap, devising and testing a set of COIs for CLD, that could be easily collected during clinical practice. Here we report the COIs generated and recorded for patients with HBV or HCV infection at different stages of the disease. Methods/Results: In the first phase of VBMH study, COIs were identified, based on current international guidelines and literature, using a modified Delphi method and a RAND 9-point appropriateness scale. In the second phase, COIs were tested in an observational, longitudinal, prospective, multicentre study based in Lombardy, Italy. Eighteen COIs were identified for HBV and HCV patients. Patients with CLD secondary to HBV (547) or HCV (1391) were enrolled over an 18-month period and followed for a median of 4years. The estimation of the proposed COIs was feasible in the real-word clinical practice and COI values compared well with literature data. Further, the COIs were able to capture the impact of new effective treatments like direct-acting antivirals (DAAs) in the clinical practice. Conclusions: The COIs efficiently measured clinical outcomes at different stages of CLDs. While specific clinical practice settings and related healthcare systems may modify their implementation, these indicators will represent an important component of the tools for a value-based approach in hepatology and will positively affect care delivery.
- Published
- 2019
46. HGV/GBV-C infection in liver transplant recipients: antibodies to the viral E2 envelope glycoprotein protect from de novo infection
- Author
-
Enrico Silini, Luca Belli, Albert B. Alberti, Margherita Asti, Antonella Cerino, Morena Bissolati, Gianfranco Rondinara, Luciano De Carlis, Domenico Forti, Mario U. Mondelli, Gaetano Ideo, Silini, E, Belli, L, Alberti, A, Asti, M, Cerino, A, Bissolati, M, Rondinara, G, De Carlis, L, Forti, D, Mondelli, M, and Ideo, G
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cirrhosis ,Hepatitis, Viral, Human ,medicine.medical_treatment ,Recurrent hepatiti ,Liver transplantation ,Anti-E2 antibodie ,Virus ,Flaviviridae ,Liver disease ,Viral Envelope Proteins ,Recurrence ,Internal medicine ,Humans ,Medicine ,Hepatitis Antibodies ,GBV-C ,Liver transplant ,Hepatitis ,Hepatology ,biology ,business.industry ,HGV ,Middle Aged ,biology.organism_classification ,medicine.disease ,Hepatitis C ,Virology ,Liver Transplantation ,Transplantation ,Immunology ,RNA, Viral ,Female ,business - Abstract
Background/Aims: Liver transplantation for end-stage liver cirrhosis provides a useful model to investigate the pathogenetic role of hepatotropic viral agents. Recently, a new member of the Flaviviridae family, provisionally named HGV/GBV-C virus, has been associated with acute and chronic non A–E hepatitis. We studied 136 patients with cirrhosis consecutively transplanted at out institution for evidence of hepatitis G virus infection and correlation with the patients' clinical course. MEthods: All patients survived for at least 6 months after transplantation (median follow-up 44 months) and underwent routine liver biopsies. Hepatitis G virus infection was studied using both direct viral RNA identification by RT-PCR and indirect detection of antibodies to the E2 glycoprotein. Results: There was high frequency of the hepatitis G virus among patients undergoing liver transplantation, with HGV RNA and anti-E2 prevalence rates of 18.4% and 26.5%, respectively. HGV RNA prevalences significantly increased after transplantation (47.8%), with 47.3% rate of new infections in susceptible subjects. Anti-E2 antibodies were significantly more prevalent among patients transplanted for HCV-related cirrhosis and represented a strong protective factor against hepatitis G virus reinfection or recurrent infection. No correlation was found between HGV RNA or anti-E2 prevalences and survival after transplantation or rates of recurrent liver damage. Conclusions: All available evidence suggests that, although liver transplant patients are heavily exposed to hepatitis G virus both before and after transplantation, hepatitis G virus does not induce liver disease in this setting. Most infections appear to be self-limited and induce a protective immunity which is marked by the presence of anti-E2 antibodies.
- Published
- 1998
47. Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease
- Author
-
M. Asti, Mario U. Mondelli, Gaetano Ideo, Enrico Silini, Giorgio Bellati, Antonella Lisa, Maria Elena Candusso, Savino Bruno, Maria D'Amico, Gabriele Grassi, Sabrina Brambilla, Angelo Franchini, Mauro Giacca, Brambilla, S, Bellati, G, Asti, M, Lisa, A, Candusso, Me, D'Amico, M, Grassi, Gabriele, Giacca, Mauro, Franchini, A, Bruno, S, Ideo, G, Mondelli, Mu, and Silini, Em
- Subjects
Adult ,Male ,Cirrhosis ,Genes, Viral ,Hepatitis C virus ,Genome, Viral ,Hepacivirus ,Biology ,medicine.disease_cause ,Virus ,Liver disease ,Viral Envelope Proteins ,Genetic variation ,medicine ,Humans ,Cloning, Molecular ,Aged ,Hepatology ,Genetic Variation ,virus diseases ,Hepatitis C ,Middle Aged ,medicine.disease ,Virology ,digestive system diseases ,Hypervariable region ,Immunology ,Female ,Asymptomatic carrier - Abstract
Hepatitis C virus (HCV) infection is a dynamic process during which molecular variants are continuously selected as the result of virus adaptation to the host. Understanding the nature of HCV genetic variation is central to current theories of pathogenesis and immune response. We prospectively studied hypervariable region 1 (HVR1) variation in the E2 gene of 36 hepatitis C patients, including 10 asymptomatic carriers, followed up for 1 to 2 years. Sequence changes in single and consecutive serum samples were assessed and correlated with clinical and virological parameters of liver disease. A region of the E1 gene was sequenced for comparison in 3 subjects. HVR1 heterogeneity at single time points widely varied in individual patients, did not increase cumulatively over the follow-up period, and did not correlate with HVR1 evolutionary rates. Conversely, the process of HVR1 sequence diversification, although differed considerably among patients, was stable over time and directly correlated with infections by HCV type 2, lower alanine aminotransferase (ALT) levels, and absence of cirrhosis. HCV carriers showed the highest HVR1 variation rates. Our findings indicate that HVR1 variation has an adaptive significance and is associated with favorable features of liver disease and suggest that prospective, rather than static, observations are required to model the process of HCV variation.
- Published
- 1998
48. PGI36 Relationship Between Clinical Severity and Health Related Quality of Life in Chronic Liver Diseases
- Author
-
M. Rota, A. Ciaccio, Luciana Scalone, Mario Strazzabosco, M. Colledan, Luca S. Belli, Giancarlo Cesana, Lorenzo G. Mantovani, Roberta Ciampichini, S. Okolicsanyi, P.A. Cortesi, G. Ideo, Scalone, L, Cortesi, P, Ciampichini, R, Okolicsanyi, S, Rota, M, Ciaccio, A, Ideo, G, Colledan, M, Belli, L, Cesana, G, Mantovani, L, and Strazzabosco, M
- Subjects
Health related quality of life ,medicine.medical_specialty ,Pathology ,Health care indicators ,Liver diseases ,Quality of care ,business.industry ,MED/42 - IGIENE GENERALE E APPLICATA ,Health Policy ,Public Health, Environmental and Occupational Health ,Alternative medicine ,MED/12 - GASTROENTEROLOGIA ,medicine ,Clinical severity ,Intensive care medicine ,business ,Liver disease ,health care economics and organizations ,Health care indicator ,MED/01 - STATISTICA MEDICA - Abstract
OBJECTIVES: To assess the relationship between the type of chronic liver diseases (CLDs), clinical severity and patients’ HRQoL. METHODS: A naturalistic, multicentre study has been conducting to identify and test quality of care indicators. Adult CLDs patients (age>18 years) have been enrolling at gastroenterology unit of 3 Italian hospitals. We are collecting socio-demographic, clinical and HRQoL data with the EQ-5D-3L. Patients are sub-grouped according to CLD type and to clinical severity using the modified Child-Turcotte-Pugh score: with this instrument, patients are classified as non-cirrhotic, early cirrhotic (class A), advanced cirrhotic (classes B and C). We conducted Kruskall-Wallis tests to assess relationship between EQ-5D-VAS score and disease type or severity score. RESULTS: Results are based on data from 2,221 patients (67% male, median age=62 years), classified into the following subgroups: HCV or HBV chronic hepatitis (36.0%), compensated cirrhosis (CC, 23.5%), hepatocellular carcinoma (HCC, 19.8%), decompensated cirrhosis (DC, 13.5%), patients in evaluation or listed for liver transplant (LT, 7.2%). Non-cirrhotic patients (HCV or HBV chronic hepatitis) had significantly (p
- Published
- 2012
49. Is hepatocellular carcinoma in cirrhosis an actual indication for liver transplantation?
- Author
-
Luca S. Belli, Abdallah Slim, E. Mazza, Gianfranco Rondinara, F. Gelosa, A. Corti, Gaetano Ideo, G. M. Iamoni, C. V. Sansalone, L. De Carlis, K. Arcieri, Paolo Aseni, G. Colella, Domenico Forti, Ernesto Minola, Alessandro Giacomoni, Colella, G, De Carlis, L, Rondinara, G, Sansalone, C, Belli, L, Aseni, P, Slim, A, Gelosa, F, Iamoni, G, Corti, A, Mazza, E, Arcieri, K, Giacomoni, A, Minola, E, Ideo, G, and Forti, D
- Subjects
Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Time Factors ,Cirrhosis ,medicine.medical_treatment ,Liver transplantation ,Gastroenterology ,Actuarial Analysis ,Cause of Death ,Internal medicine ,medicine ,Humans ,Neoplasm Invasiveness ,Neoplasm Staging ,Retrospective Studies ,Transplantation ,business.industry ,Liver Neoplasms ,Middle Aged ,medicine.disease ,Liver Transplantation ,Surgery ,Survival Rate ,Hepatocellular carcinoma ,Female ,Complication ,business - Published
- 1997
50. Immunogenetic factors, HCV genotypes, and HCV recurrence after liver transplantation
- Author
-
Domenico Forti, Gaetano Ideo, Claudio Zavaglia, Enrico Silini, Carmine Tinelli, Mario Scalamogna, Antonino Alberti, Gianfranco Rondinara, Luca S. Belli, Francesca Poli, L. De Carlis, Belli, L, Zavaglia, C, Alberti, A, Rondinara, G, De Carlis, L, Silini, E, Poli, F, Scalamogna, M, Tinelli, C, Forti, D, and Ideo, G
- Subjects
Liver Cirrhosis ,Time Factors ,Genotype ,Hepatitis C virus ,medicine.medical_treatment ,Hepacivirus ,Liver transplantation ,medicine.disease_cause ,Flaviviridae ,Postoperative Complications ,Recurrence ,medicine ,Humans ,Risk factor ,Alleles ,Retrospective Studies ,Transplantation ,biology ,Histocompatibility Testing ,Graft Survival ,HLA-DR Antigens ,biology.organism_classification ,Hepatitis C ,Liver Transplantation ,Immunology ,Surgery ,Viral disease ,Follow-Up Studies ,HLA-DRB1 Chains - Published
- 1999
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