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Background: The open-label, single-arm, multicenter ORZORA trial (NCT02476968) evaluated the efficacy and safety of maintenance olaparib in patients with platinum-sensitive relapsed ovarian cancer (PSR OC) who had tumor BRCA mutations (BRCAm) of germline (g) or somatic (s) origin or non-BRCA homologous recombination repair mutations (HRRm) and were in response to their most recent platinum-based chemotherapy after ≥2 lines of treatment. Methods: Patients received maintenance olaparib capsules (400mg twice daily) until disease progression. Prospective central testing at screening determined tumor BRCAm status and subsequent testing determined gBRCAm or sBRCAm status. Patients with predefined non-BRCA HRRm were assigned to an exploratory cohort. The co-primary endpoints were investigator-assessed progression-free survival (PFS; modified Response Evaluation Criteria in Solid Tumors v1.1) in BRCAm and sBRCAm cohorts. Secondary endpoints included health-related quality of life (HRQoL) and tolerability. Results: 177 patients received olaparib. At the primary data cut-off (17 April 2020), the median follow-up for PFS in the BRCAm cohort was 22.3months. The median PFS (95% CI) in BRCAm, sBRCAm, gBRCAm and non-BRCA HRRm cohorts was 18.0 (14.3-22.1), 16.6 (12.4-22.2), 19.3 (14.3-27.6) and 16.4 (10.9-19.3) months, respectively. Most patients with BRCAm reported improvements (21.8%) or no change (68.7%) in HRQoL and the safety profile was as expected. Conclusions: Maintenance olaparib had similar clinical activity in PSR OC patients with sBRCAm and those with any BRCAm. Activity was also observed in patients with a non-BRCA HRRm. ORZORA further supports use of maintenance olaparib in all patients with BRCA-mutated, including sBRCA-mutated, PSR OC.

El género romántico se encuentra presente en todas las formas existentes de entretenimiento por la capacidad que presenta de apelar a sentimientos y emociones comunes, traspasando diferencias sociales y culturales. En el trabajo que aquí se presenta, la atención se ha centrado en el género romántico dentro de los videojuegos. Existe un considerable interés por este tipo de creaciones, pero, dicho interés, resulta incompleto. Mayoritariamente, las investigaciones que se han realizado sobre este tipo de videojuegos, aunque se han desarrollado desde múltiples y variadas perspectivas, se han centrado en juegos desarrollados en Asia, conocidos como Otome. Sin embargo, si se centra la atención fuera de oriente, los videojuegos de género romántico existentes han sido, en gran medida, ignorados hasta el punto de negar su existencia. Esta investigación busca reivindicar estas creaciones olvidadas mediante el análisis de un estudio de caso concreto Choices: Stories you play. Aplicando el análisis de contenido, y partiendo de los elementos característicos de la literatura romántica, esta investigación demuestra que el videojuego seleccionado pertenece al género romántico, poniendo de manifiesto que este tipo de videojuegos no son exclusivamente orientales.

Hace décadas se tenía una percepción de cuerpo y mente de forma independiente. Sin embargo, hoy en día son percibidas como un conjunto, ya que ha quedado demostrado que el ejercicio físico tiene consecuencias a nivel cognitivo. Por esta razón, en esta investigación se propone conocer la relación que existe entre la realización o no de ejercicio físico con la repetición de uno o más cursos en adolescentes. Para ello, se ha utilizado una muestra de un total de 706 adolescentes de institutos pertenecientes a la provincia de Granada. Se les ha pasado el cuestionario PAQ-A, así como uno ad hoc y posteriormente, se han analizado los resultados con el programa estadístico SPSS. Se ha concluido que, aunque el deporte es una variable que ejerce importancia, no es un factor determinante a la hora de que los adolescentes repitan curso. Palabras claves: Deportes; Actividad física; Rendimiento académico; Adolescentes. Abstract. Decades ago, body and mind were perceived independently, but nowadays they are perceived as a whole, as it has been demonstrated that physical exercise has consequences at a cognitive level. For this reason, the aim of this research is to find out the relationship between doing or not doing physical exercise and the repetition of one or more courses in adolescents. For this purpose, a sample of 706 adolescents from secondary schools in the province of Granada was used. They were given the PAQ-A questionnaire, as well as an ad hoc questionnaire, and the results were subsequently analysed using the SPSS statistical programme. It was concluded that, although sport is an important variable, it is not a determining factor when it comes to adolescents repeating a year. Key words: Sports; Physical activity; Academic performance; Teenagers.

El objetivo de la investigación fue profundizar en la investigación mediante la exploración de la tendencia de la economía circular específicamente en el área de gestión, negocios y economía. La metodología utilizada es descriptiva, una revisión bibliométrica de los artículos científicos sobre la economía circular (613 artículos), publicados en revistas indizadas en la Web of Science, el periodo seleccionado fue del 2009 al 2023. La producción se incrementó notablemente a partir del año 2019 con 80 artículos. Se realizaron mapas de co-ocurrencia de palabras, títulos y resúmenes de la economía circular. Como principales conclusiones se tienen los países con mayor colaboración como: China, Reino Unido, Estados Unidos e India. La economía circular es relevante y significativa a nivel mundial entre las diferentes naciones organizaciones, legisladores, instituciones académicas, académicos, investigadores y empresas, es considerada una solución a los desafíos ecológicos y socioeconómicos resultantes del consumo creciente de recursos no renovables, la generación de desechos sólidos y electrónicos, la contaminación (suelo, agua y atmósfera), así como la escasez de recursos. Se abre una ventana a las investigaciones relacionadas con el área de gestión, negocios y economía.

Reseña de monográfico sobre Disponibilidad léxica

How can regularization programs improve forced migrants' resilience to shocks? We leverage panel data collected during the COVID-19 pandemic to assess whether Venezuelan forced migrants who were eligible for a regularization program in Colombia were more resilient and less affected by the pandemic than similar but noneligible forced migrants. Results indicate that access to the program promoted better health access for eligible migrants, facilitating adherence to prevention guidelines and increasing detection rates. Additionally, eligible migrants had better housing and labor conditions, relative to noneligible migrants.

We performed a retrospective analysis of the patients assessed at our memory unit for whom Alzheimer disease (AD) cerebrospinal fluid biomarker results were available. We selected patients diagnosed with mild cognitive impairment due to AD (National Institute on Aging-Alzheimer's Association clinical criteria), confirmed neuropsychological deficit, a Global Deterioration Scale score of 3, and an abnormal profile of cerebrospinal fluid biomarkers. Of the 588 cases reviewed, 110 met the inclusion criteria. During follow-up, 50 cases (45.45%) progressed to dementia due to AD. Baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. After adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28-3.84]; P = .004). Among patients with mild cognitive impairment due to AD and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia.

Resumen Introduccion Junto con el envejecimiento de la poblacion general, la prevalencia de ancianos con esclerosis multiple (EM) se encuentra en aumento. El sistema inmunologico sufre profundos cambios a lo largo de la vida, por lo que parece imprescindible conocer que diferencias presentan respecto a pacientes mas jovenes. Desarrollo La inmunosenescencia, definida como la alteracion del sistema inmunologico en relacion con el envejecimiento natural, juega un papel esencial en la tolerancia, efectos adversos y respuesta a los tratamientos modificadores de la enfermedad. Entre las principales caracteristicas de este fenomeno, la involucion que sufre el timo es la mas destacable. Este hecho genera una reduccion en la produccion de celulas T virgenes. Ademas, se observa una ratio de linfocitos CD4 + /CD8 + invertido, alteraciones severas en el funcionamiento de las celulas NK o una disminucion en la capacidad de reparacion tisular cerebral. Conclusiones El numero de personas de edad avanzada con EM se encuentra en aumento en coincidencia con el envejecimiento de la poblacion general y gracias al avance en los tratamientos modificadores de la enfermedad, asi como a la mejora en la asistencia sociosanitaria de estos pacientes. El envejecimiento del sistema inmunitario conlleva un mayor riesgo de infecciones, tumores y enfermedades autoinmunes en los ancianos. En la EM, ademas, tiene lugar una aceleracion en la neurodegeneracion por la perdida de capacidad de remielinizacion del sistema nervioso. Conocer los cambios que tienen lugar en el sistema inmunologico de la poblacion de edad avanzada es esencial para mejorar la atencion de este grupo de pacientes cada vez mas prevalente.

El capítulo se centra en el análisis de cómo la televisión evolucionó desde su creación hasta convertirse en el medio heterogéneo que es hoy en día. La introducción de la Realidad Virtual en este medio, resultado de los avances tecnológicos en la industria de los contenidos, transformaron no sólo la forma de consumir entretenimiento e información, sino la forma de producirlo. A su vez, estos avances, unidos a la versatilidad de tecnologías de computación en la nube, permitieron transitar desde el medio televisivo al educativo, donde cuenta con la posibilidad de convertirse en una modalidad específica de formación. Hoy, la transferencia es posible gracias a la universalización y abaratamiento de costes en un sector que, como el educativo, exige tecnologías accesibles en cuanto al uso e implementación del hardware y el software. En el capítulo se describen las distintas modalidades que resultan de combinar realidad virtual y física, para posteriormente focalizar en el paso del estudio de producción tradicional al set virtual en el medio televisivo, así como su traslado al ámbito educativo. Palabras clave: televisión, realidad, virtual, producción, digital, nube, docencia, educación.

The pathogens in fish generate alterations in physiology of fish with consequences in life function decreasing and death. Objective. To analyzed the response of ornamental fish Etroplus maculatus (Teleostei: Cichlidae) and Puntius ticto (Teleostei: Cyprinidae) infected by Pseudomonas aeruginosa (PSA1) and Enterobacter cloacae (EMS1). Methods. Strains of bacteria Pseudomonas aeruginosa (PSA1) and Enterobacter cloacae (EMS1) were obtained from moribund individuals of Etroplus maculatus (Teleostei: Cichlidae) and Puntius ticto (Teleostei: Cyprinidae), also hemaglobin, hematocrit, erythrocyte, and hemoglobin in an erythrocyte, oxygen consumption and ammonium excretion, and histological studies were measured. Results. Hematological parameters (hemaglobin, hematocrit, erythrocyte, hemoglobin in an erythrocyte) denoted an inverse relation with bacterial infection for both species, which was supported by high oxygen consumption, high ammonium excretion, and cell damage showed using histological analysis. Conclusions. These results are similar to observations for inland water and marine fish under culture conditions. The artificial infection of two fish species with two pathogen bacteria generates effects in pathophysiology and can be used for the development of treatment approaches.

En las últimas décadas las comunidades patrimoniales se han convertido en conservadoras y transmisoras de los patrimonios que han estado en peligro de desaparición, donde acciones colectivas han sido destinadas a la preservación de elementos patrimoniales en situación de desamparo. En este trabajo se recoge el nacimiento y desarrollo de las actividades desarrolladas en el Centro Comunitario Uj-ja’ Síijo’ob de Canicab, Yucatán, desde su inauguración en el año 2012 hasta la actualidad. Este proyecto surge unido a un grupo de voluntarios, pretendiendo ser un espacio de alfabetización de niños y adultos en primera instancia, para acabar siendo un espacio de diálogo abierto a toda la comunidad, en el que el patrimonio y la educación son los dos ejes clave. De este modo, se muestra un ejemplo del valor de las comunidades patrimoniales en la preservación y transmisión del patrimonio cultural maya en México.

En el presente estudio se analiza la doctrina del Tribunal Constitucional sobre el significado y función de la regla de la prevalencia del Derecho estatal que establece el art. 149.3 de la Constitución. Algunas decisiones recientes del Tribunal Constitucional han ofrecido una interpretación algo distinta de la que venía siendo tradicional, permitiendo la inaplicación de las leyes autonómicas en determinados supuestos. El artículo pretende dar cuenta de la evolución de dicha doctrina del Tribunal y su situación en el momento actual.

El acetaminofén es un fármaco ampliamente usado en el mundo y de fácil acceso por sus características antipiréticas, analgésicas, entre otras (1); sin embargo la exposición a dosis tóxicas produce daños a nivel orgánico e incluso la muerte. Presentamos el caso de una paciente mujer de 18 años que ingirió 40 gramos de acetaminofén y desarrolló injuria hepática severa, siendo tratada con terapia antidotal de N-acetilcisteína (NAC) según el esquema simplificado: Scottish and Newcastle Anti-Emetic Pretreatment Paracetamol Poisoning Study Regimen (SN ución de los perfiles hepáticos, trastorno de coagulación, INR y resolución del cuadro.

El objetivo de este estudio es la elaboración de un cuestionario de evaluación del miedo a la recurrencia del cáncer en español. Método: se presenta un estudio piloto de diseño correlacional trasversal elaborado en dos fases: 1) creación del cuestionario del miedo a la recurrencia del cáncer (CMRC) y de la Escala General del Miedo a la Recurrencia del Cáncer (EGMRC); 2) evaluación de sus propiedades psicométricas. Resultados: para la elaboración de los cuestionarios se utilizó el acuerdo entre expertos medido por la V de Aiken. El CMRC queda finalmente configurado con 8 ítems que se responden con una escala tipo Likert de 0-4 y un Alfa de Cronbach de 0,85. La EGMRC de una sola pregunta que se responde con una escala de 0-100 correlaciona hasta un 0,84 con el CMRC. Se utilizó una muestra de 50 mujeres supervivientes de cáncer ginecológico seleccionadas en el Hospital Universitario Clínico San Carlos de Madrid. Ambas escalas correlacionan con el nivel de ansiedad de las pacientes y la función emocional de calidad de vida. No se hallan correlaciones con los niveles de depresión. Conclusiones: El CMRC y la EGMRC son dos instrumentos que pueden ser válidos para la evaluación del miedo a la recurrencia del cáncer en pacientes supervivientes de cáncer ginecológico.

Today, regenerative osteogenesis represents a clinical need, due to the incidence of bone defects that involve groups of pathologies ranging from congenital anomalies to traumatic injuries, as well as problems presented surgically. This is why the design of a polymeric biomaterial (scaffold) of chitosan, carboxymethylcellulose, zinc oxide, and calcium carbonate with similar characteristics in terms of composition and bone structure offers high potential to help address this health problem. The technique for obtaining the scaffolds of this research was to develop a physical hydrogel to have the biofunctionality of the active groups of the polymer chains used, then make use of the lyophilization process to obtain three-dimensional (3D) porous scaffolds. The physicochemical and biological properties of the scaffolds were evaluated. The scaffolds presented morphology with pore size and interconnectivity that favor the need for cell proliferation and viability. The biocompatibility tests confirm that the designed scaffolds do not present cytotoxicity and the analyzes with alizarin red staining show calcium deposits in the materials with CaCO3 and ZnO. Osteoinduction assays to osteogenic lineage using runt-related transcription factor type 2 (RUNX2) and collagen type 1 (COL-1) antibodies allowed expression in differentiated cells. Therefore, the calcium carbonate-containing scaffolds stabilized by physical bonds have characteristics of being non-cytotoxic, bioactive, and osteoinductive, which motivate their use in future tests to evaluate their demeanor with rat models for bone engineering studies.

Schizophrenia has been associated with dysfunction in information integration/ segregation dynamics. One of the neural networks whose role has been most investigated in schizophrenia is the default mode network (DMN). In this study, we have explored the possible alteration of integration and segregation dynamics in individuals diagnosed with schizophrenia with respect to healthy controls, based on the study of the topological properties of the graphs derived from the functional connectivity between the nodes of the DMN in the resting state. Our results indicate that the patients show a diminution of the modularity of the DMN and a higher global efficiency, in sparse graphs. Our data emphasise the interest in studying temporal changes in network measures and are compatible with the hypothesis of randomization of functional networks in schizophrenia., Agencia Estatal de Investigacion, AEI PID2019-105145RB-I00

Herbivores affect plants via direct consumption, but also indirectly via changes in the vegetation. These indirect effects may only manifest after decades of exposure and, as a result, their impact is rarely accounted for. To better understand the direct and indirect impacts of a large herbivore, moose ( Alces alces), on forests, we measured tree growth in areas that were both subjected to and excluded from herbivory for over 80 years. Growth data were gathered from five tree species, ranging from low to high palatability. We found that at small sizes, Betula papyrifera, a preferred species, benefited from herbivore exclusion. However, larger individuals grew more when exposed to herbivory, a response we attribute to lower competition in heavily browsed conditions. Populus tremuloides, a highly preferred tree, did not show any differences between levels of herbivory. Abies balsamea, a preferred winter browsed, was only marginally affected by browsing at smaller sizes. The two non-preferred species, Picea glauca and Picea mariana, did not show differential growth between herbivory levels. We conclude that herbivores can impact forests through both direct and indirect effects, that these effects are size specific, and that effects vary among species in ways not always predicted by consumption patterns.

Background Patient empowerment through pharmacological self-management is a common strategy in some chronic diseases such as diabetes, but it is rarely used for controlling blood pressure. Objective This study aimed to assess self-monitoring plus self-titration of antihypertensive medication versus usual care for reducing systolic blood pressure (SBP) at 12 months in poorly controlled hypertensive patients. Design The ADAMPA study was a pragmatic, controlled, randomized, non-masked clinical trial with two parallel arms in Valencia, Spain. Participants Hypertensive patients older than 40 years, with SBP over 145 mmHg and/or diastolic blood pressure (DBP) over 90 mmHg, were recruited from July 2017 to June 2018. Intervention Participants were randomized 1:1 to usual care versus an individualized, pre-arranged plan based on self-monitoring plus self-titration. Main Measure The primary outcome was the adjusted mean difference (AMD) in SBP between groups at 12 months. Key Results Primary outcome data were available for 312 patients (intervention n=156, control n=156) of the 366 who were initially recruited. The AMD in SBP at 12 months (main analysis) was −2.9 mmHg (95% CI, −5.9 to 0.1, p=0.061), while the AMD in DBP was −1.9 mmHg (95% CI, −3.7 to 0.0, p=0.052). The results of the subgroup analysis were consistent with these for the main outcome measures. More patients in the intervention group achieved good blood pressure control (p=0.017). At 12 months, no differences were observed in behavior, quality of life, use of health services, or adverse events. Conclusion Self-monitoring plus self-titration of antihypertensive medication based on an individualized pre-arranged plan used in primary care may be a promising strategy for reducing blood pressure at 12 months compared to usual care, without increasing healthcare utilization or adverse events. Trial Registration EudraCT, number 2016-003986-25 (registered 17 March 2017) and clinicaltrials.gov, NCT03242785.

A partir de la importancia que ha tomado la Delincuencia Organizada Transnacional actualmente, que se favorece por el proceso de globalización internacional, este libro busca abordar aquellas amenazas que en el marco de la seguridad multidimensional se categorizan en esta tipología criminal. En este sentido, el objetivo de esta investigación es analizar la incidencia de la Delincuencia Organizada Transnacional, tanto en la región como en Colombia. Esta investigación es un avance en la exploración de las amenazas a la seguridad que enfrentan las fronteras colombianas y trata temas de la coyuntura nacional e internacional, esperándose que sea un insumo de futuras investigaciones y proyecciones estatales en el abordaje de las amenazas de la Delincuencia Organizada Transnacional.

Background: To evaluate the real-world effect of the IL-12/23 inhibitor ustekinumab or of a tumour necrosis factor inhibitor (TNFi) on patient-reported outcomes (PRO) and their association with effectiveness endpoints in psoriatic arthritis (PsA) patients over 3 years. Methods: In PsABio (NCT02627768), a prospective, observational study, patients with PsA that were prescribed first- to third-line ustekinumab or a TNFi, and remained on that drug for 3 years, were analysed for change in baseline in PROs (EuroQol-5 dimensions health state VAS [EQ-5D VAS], 12-item Psoriatic Arthritis Impact of Disease questionnaire [PsAID-12; range 0–10], Work Productivity and Activity Impairment for Psoriatic Arthritis questionnaire [WPAI; results expressed as a percentage for each domain]), and the association between PROs and WPAI with effectiveness endpoints, clinical disease activity index for psoriatic arthritis (cDAPSA), low disease activity (LDA)/remission, minimal disease activity (MDA) and very low disease activity (VLDA). Results: In 437 patients (mean age 49.1 years, 47.8% female), at 3 years, ustekinumab and TNFi treatment led to comparable improvements in EQ-5D VAS; mean change from baseline (95% confidence intervals [CI]) was 11.0 (6.5; 15.4) and 18.9 (14.0; 23.9), respectively. Both groups improved PsAID-12 after 3 years; mean change from baseline (95% CI) was −2.9 (−3.2; −2.5) and −3.5 (−3.9; −3.2), respectively. At baseline, due to their PsA, TNFi-treated patients had lower work productivity compared to ustekinumab-treated patients; mean productivity reduction (95% CI) was 58.8 [52.4; 65.2] and 43.3 [35.6; 51.1]. Over 3 years, TNFi-treated patients had a greater improvement in work productivity compared to ustekinumab-treated patients, ultimately leaving work productivity to be comparable between groups; mean improvement (95% CI) was 44.5% (38.4; 50.6) and 24.9% (15.8; 34.0), respectively. A similar trend was observed in activity impairment. Patients in both treatment groups who achieved effectiveness endpoints, cDAPSA LDA/remission, MDA, and VLDA had greater improvement in PROs and WPAI than patients who did not achieve these endpoints. Conclusions: At 3 years, improvements in PROs following ustekinumab or TNFi treatment were generally comparable; however, TNFi-treated patients achieved a greater improvement in work productivity, although this group started from a lower baseline. Achievement of effectiveness endpoints, independent of treatment group, also improved PROs. Trial registration: ClinicalTrials.gov, NCT02627768. Registered on 11 December 2015.

Este estudio valora el desarrollo de la competencia docente para llevar a las aulas de Educación Primaria temas controvertidos con el apoyo de recursos digitales, a partir del trabajo realizado con profesorado en formación de la Universidad del País Vasco UPV/EHU. En el Proyecto 1936, que tiene como eje temático la memoria histórica y hace uso de la app Eibar 1936-1937 Guía como recurso educativo, han participado 142 alumnos, 26 dentro del grupo experimental y 116 como grupo de control. El estudio tiene un enfoque mixto, con el análisis cualitativo de las propuestas didácticas que los participantes diseñan y el tratamiento cuantitativo del cuestionario que responden sobre la percepción de sus capacidades. Los resultados indican que mejora notablemente la auto-percepción sobre su formación para abordar temas conflictivos en las aulas, con mediación de tecnología. Las propuestas que diseñan alcanzan en general niveles medios y altos de adecuación, centrándose en temáticas locales y haciendo uso de testimonios, si bien pueden mejorarse aspectos, como el nivel de integración de la app y el tratamiento de memorias enfrentadas.

El análisis estadístico descriptivo es el primer paso que cualquier persona que pretenda realizar una investigación cuantitativa debe dar cuando se dispone a realizar el análisis de los datos recogidos durante el trabajo de campo de su investigación. Es fundamental conocer de una forma descriptiva las características de la población participante en el estudio y los resultados iniciales obtenidos, como paso previo a la realización de análisis inferenciales o al ajuste de modelos estadísticos que expliquen de forma más profunda los datos obtenidos. Este trabajo presenta una introducción a las diferentes variables que nos podemos encontrar y a la implementación de su análisis descriptivo mediante el software estadístico libre jamovi. Se muestra, por tanto, una herramienta sin coste alguno que ofrece resultados potentes sin necesidad de conocer un lenguaje de programación estadístico.

Objetivos: a) Comparar la fuerza de ruptura (FR), adaptación marginal externa (AME) y angulación intracuspídea (AI) entre carillas oclusales confeccionadas con composite, cerámica híbrida y feldespática obtenidas con sistemas CADCAM fijadas con distintos medios cementantes y b) evaluar si el medio cementante, la AME y la AI influyen en la FR. Materiales y métodos: 50 premolares conformaron 6 grupos de acuerdo a la combinación de los materiales Cp, omposite Paradigm MZ100 (P), Cerámica híbrida VitaEnamic (VE), Cerámica feldespática Vitablocks Mark II (F) con los cementos Variolink N curado dual (VN) o resina compuesta Z100 calentada (RC): Grupo 1 (n=10) P-VN, Grupo 2 (n=10) P-RC, Grupo 3 (n=10) VE-RC, Grupo 4 (n=10) VE-VN, Grupo 5 (n=5) F-VN, Grupo 6 (n=5) F-RC. Los dientes preparados y acondicionados recibieron carillas confeccionadas utilizando el Sistema Cerec 3. Luego, fueron sometidas a fuerzas compresivas en una máquina de ensayos universal, aplicando una carga con una velocidad de desplazamiento igual a 0,5 mm/ minuto hasta el cese por fractura catastrófica. Previo a realizar los ensayos se midió la AME en sus cuatro caras y la AI. Resultados: Se obtuvieron valores de mayor FR para los Grupos 1 y 2, que se diferenciaron significativamente de los otros 4 grupos (p0,05). Hubo diferencias con relación a los materiales y la AME favoreciendo al Grupo 1 (p

Background: Although social cognition is compromised in patients with neurodegenerative disorders such as behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD), research on moral emotions and their neural correlates in these populations is scarce. No previous study has explored the utility of moral emotions, compared to and in combination with classical general cognitive state tools, to discriminate bvFTD from AD patients. Objective: To examine self-conscious (guilt and embarrassment) and other-oriented (pity and indignation) moral emotions, their subjective experience, and their structural brain underpinnings in bvFTD (n = 31) and AD (n = 30) patients, compared to healthy controls (n = 37). We also explored the potential utility of moral emotions measures to discriminate bvFTD from AD. Methods: We used a modified version of the Moral Sentiment Task measuring the participants’ accuracy scores and their emotional subjective experiences. Results: bvFTD patients exhibited greater impairments in self-conscious and other-oriented moral emotions as compared with AD patients and healthy controls. Moral emotions combined with general cognitive state tools emerged as useful measures to discriminate bvFTD from AD patients. In bvFTD patients, lower moral emotions scores were associated with lower gray matter volumes in caudate nucleus and inferior and middle temporal gyri. In AD, these scores were associated with lower gray matter volumes in superior and middle frontal gyri, middle temporal gyrus, inferior parietal lobule and supramarginal gyrus. Conclusion: These findings contribute to a better understanding of moral emotion deficits across neurodegenerative disorders, highlighting the potential benefits of integrating this domain into the clinical assessment.

Although numerous comparisons between conventional Two Stage Hepatectomy (TSH) and Associating Liver Partition and Portal Vein Ligation for staged hepatectomy (ALPPS) have been reported, the heterogeneity of malignancies previously compared represents an important source of selection bias. This systematic review and meta-analysis aimed to compare perioperative and oncological outcomes between TSH and ALPPS to treat patients with initially unresectable colorectal liver metastases (CRLM).Main electronic databases were searched using medical subject headings for CRLM surgically treated with TSH or ALPPS. Patients treated for primary or secondary liver malignancies other than CRLM were excluded.A total of 335 patients from 5 studies were included. Postoperative major complications were higher in the ALPPS group (relative risk [RR] 1.46, 95% confidence interval [CI] 1.04-2.06, IALPPS and TSH to treat CRLM seem to have comparable operative risks in terms of mortality rates. No definitive conclusions regarding OS and DFS can be drawn from the results.

Background: Different questionnaires have been developed globally to assess and compare the impact of food allergy on the quality of life. The aim of this study was to validate a Spanish translation of the Food Allergy Independent Measure (FAIM) and the EuroPrevall Food Allergy–Quality of Life Questionnaire–Teenage Form (FAQLQ-TF) for adolescents aged 13–17 years. Methods: Sixty adolescents diagnosed with immunoglobulin E-mediated allergy to food completed the questionnaires. Cronbach’s alpha was used to assess internal consistency; correlation between FAQLQ-TF and FAIM was used to test construct validity. The discriminant validity was evaluated by comparison with the number of offending foods, the perceived impact on social life, the diagnosis of anaphylaxis, and the previous prescription of adrenaline auto--injectors (AAI). Results: No question fulfilled criteria to be removed from the questionnaire. For FAIM, Cronbach’s alpha = 0.763, and for the four domains of FAQLQ-TF, Cronbach’s alpha = 0.797–0.847. A significant correlation existed between FAQLQ-TF and FAIM, and of both of them with anaphylaxis and the prescription of AAI (P ˂ 0.05 for all comparisons). Conclusions: This Spanish translation of FAIM and FAQLQ-TF for adolescents had good internal consistency and construct validity as well as ability to discriminate patients according to the number of foods to avoid, impact on social life, diagnosis of anaphylaxis, and AAI prescription.

Art education is a valuable tool for achieving quality education by fostering creativity and an appreciation of learning and culture. Well-designed learning spaces are conducive to art learning. The COVID-19 pandemic prompted the author to review the design of learning spaces employed in previous pandemics and other outdoor learning spaces developed over time. A project was carried out at the university level with future secondary school art teachers to design a sustainable art learning space as a multidisciplinary exercise, combining art, architecture and design. Solutions were analysed across multiple criteria. The results demonstrate the suitability of the proposed activity to promote critical creativity among students in Tenerife in the Canary Islands. This type of project in art education is essential for academics and educators so that they become involved in sustainability issues so present in contemporary life.